@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1695: (2016-05-04 )
MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAVDRGSLHLAPDDMRAMGVEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPVLGVNLGRIGFLAEAEAEAIDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCVTSVKWARLDSAPFTDRLVRKFRLPVTGWRGK
Atome Classification :
(22 SA)
----------------------------.........10..-......20........-30.--.......40........50.......--.60---..---...-....70........80........90....--..--..100..-......110.......120.......130...--....140.....---..-150........160.......170.......180.......190.......200.......-210......-.220---.........-----230.......240.-.....------.250........260.......270....-------...280------...--.....290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MTA
H
R
S
V
L
L
V
V
HT-GRD
E
A
T
E
T
A
R
R
V
E
K
V
L-GDN--
K
I
A
L
R
V
L
S
A
EAVDRGSLHLAPD
D
M
R
A--MG----
V
E
---
I
E
V
-
V
DADQHAADG
C
E
L
V
L
V
LGGDG
T
F
L
R
A
A
E
L
A--RN--ASI
P
-
V
L
-
G
VNLG
R
I
G
F
LAE
A
E
A
E
A
I
D
A
V
L
E
H
V
V
AQDYRV--ED
R
L
T
L
D
V
V
VRQ---G
G
-
R
-
I
VNRGWALNEVSLEKGPRL
G
V
L
G
V
V
V
E
IDG
R
P
VSAFGCD
G
V
L
V
STPTGS
T
A
Y
A
FSAGGP-VLWPD
L
E
A
I
-
L
V
-----VPNNA
H
A
LF-----GRPMVTSPE
A
T
I
A
I
-
E
I
EAD------GH
D
-
A
L
V
F
CDGR
R
E
M
L
IPAGS
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------ARL--DSAP
F
T
D
R
L
V
R
K
FRLPVTGWRGK
1
PsiBlast_PDB
95.31
100%
-137
- C6 -
1U0R
-
NADK_MYCTU
A:
[4-305]
-------------------------------
H
R
S
V
L
L
V
V
H
T
-----
A
T
E
T
A
R
R
V
E
K
V
L
-
G
D
N
--
K
I
A
L
R
V
L
S
A
E
A
V
-----------------------
E
---
I
E
V
-
V
D
A
D
Q
H
A
A
D
G
C
E
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
--
A
S
I
P
-
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
--
E
D
R
L
T
L
D
V
V
V
R
Q
---
G
G
-
R
-
I
V
N
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
-
L
V
-----
V
P
N
N
A
H
A
L
F
-----
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
-
A
L
V
F
C
D
G
R
R
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------
A
R
L
--
D
S
A
P
F
T
D
R
L
V
R
K
F
R
L
P
V
T
G
W
R
--
2
PsiBlast_PDB
92.65
100%
-141
- C6 -
1U0T
-
NADK_MYCTU
A:
[5-306]
--------------------------------
R
S
V
L
L
V
V
H
T
-
G
R
D
E
A
T
E
T
A
R
R
V
E
K
V
L
-
G
D
N
--
K
I
A
L
R
V
L
S
---------------------------------------------
C
E
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
--
A
S
I
P
-
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
--
E
D
R
L
T
L
D
V
V
V
R
Q
---
G
G
-
R
-
I
V
N
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
-
L
V
-----
V
P
N
N
A
H
A
L
F
-----
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
-
A
L
V
F
C
D
G
R
R
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------
A
R
L
--
D
S
A
P
F
T
D
R
L
V
R
K
F
R
L
P
V
T
G
W
R
G
-
29
HHSearch
92.25
98%
-141
- C6 -
1U0T
-
NADK_MYCTU
A:
[5-306]
--------------------------------
R
S
V
L
L
V
V
H
T
-
G
R
D
E
A
T
E
T
A
R
R
V
E
K
V
L
-
G
D
N
--
K
I
A
L
R
V
L
S
---------------------------------------------
C
E
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
--
A
S
I
P
-
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
--
E
D
R
L
T
L
D
V
V
V
R
Q
---
G
G
-
R
-
I
V
N
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
-
L
V
-----
V
P
N
N
A
H
A
L
F
-----
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
-
A
L
V
F
C
D
G
R
R
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------
A
R
L
--
D
S
A
P
F
T
D
R
L
V
R
K
F
R
L
P
V
T
G
W
R
G
-
4
PsiBlast_PDB
92.01
99%
-138
- C6 -
1Y3H
-
NADK_MYCTU
A:
[5-307]
--------------------------------
R
S
V
L
L
V
V
H
T
------
T
E
T
A
R
R
V
E
K
V
L
-
G
D
N
--
K
I
A
L
R
V
L
S
----------------------------------------
H
A
A
D
G
C
E
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
--
A
S
I
P
-
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
--
E
D
R
L
T
L
D
V
V
V
R
Q
---
G
G
-
R
-
I
V
N
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
-
L
V
-----
V
P
N
N
A
H
A
L
F
-----
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
-
A
L
V
F
C
D
G
R
R
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------
A
R
L
--
D
S
A
P
F
T
D
R
L
V
R
K
F
R
L
P
V
I
G
W
R
G
K
21
PsiBlast_CBE
80.39
100%
-135
- C6 -
1Y3I
4
NADK_MYCTU
B:
[7-302]
----------------------------------
V
L
L
V
V
H
-------------------------------------------------------------------------------
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
--
A
S
I
P
-
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
--
E
D
R
L
T
L
D
V
V
V
R
Q
---
G
G
-
R
-
I
V
N
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
-
L
V
-----
V
P
N
N
A
H
A
L
F
-----
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
-
A
L
V
F
C
D
G
R
R
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------
A
R
L
--
D
S
A
P
F
T
D
R
L
V
R
K
F
R
L
P
V
T
-----
3
PsiBlast_PDB
79.32
100%
-128
- C6 -
1Y3I
3
NADK_MYCTU
A:
[7-302]
----------------------------------
V
L
L
V
V
H
-------------------------------------------------------------------------------
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
--
A
S
I
P
-
V
L
-
G
V
N
L
G
R
I
G
F
L
A
E
A
E
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
--
E
D
R
L
T
L
D
V
V
V
R
Q
---
G
G
-
R
-
I
V
N
R
G
W
A
L
N
E
V
S
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
G
R
P
V
S
A
F
G
C
D
G
V
L
V
S
T
P
T
G
S
T
A
Y
A
F
S
A
G
G
P
-
V
L
W
P
D
L
E
A
I
-
L
V
-----
V
P
N
N
A
H
A
L
F
-----
G
R
P
M
V
T
S
P
E
A
T
I
A
I
-
E
I
E
A
D
------
G
H
D
-
A
L
V
F
C
D
G
R
R
E
M
L
I
P
A
G
S
R
L
E
V
T
R
C
V
-------
T
S
V
K
W
-------
A
R
L
--
D
S
A
P
F
T
D
R
L
V
R
K
F
R
L
P
V
T
-----
48
Fugue
68.77
29%
-118
- C6 -
2AN1
-
NADK_SALTY
A:
[4-292]
------------------------------
H
F
K
C
I
G
I
V
--------
G
H
T
T
H
E
M
L
Y
R
W
L
-
C
D
Q
--
G
Y
E
V
I
V
E
Q
Q
I
A
H
E
L
Q
L
K
N
V
P
T
G
T
L
A
E
--
I
G
----
Q
Q
-----------------
A
D
L
A
V
V
V
G
G
D
G
N
M
L
G
A
A
R
T
L
--
A
R
--
Y
D
I
N
-
V
I
-
G
I
N
R
G
N
L
G
F
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
--
E
K
R
F
L
L
E
A
Q
V
C
Q
---
Q
------
R
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
E
T
F
A
F
S
Q
R
S
D
G
L
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
P
-
I
L
T
P
S
L
D
A
I
-
T
L
-----
V
P
M
F
P
H
T
L
S
-----
A
R
P
L
V
I
N
S
S
S
T
I
R
L
-
R
F
S
---------
H
D
-
L
E
I
S
C
D
S
Q
I
A
L
P
I
Q
E
G
E
D
V
L
I
R
R
C
D
-------
Y
H
L
N
L
-------
I
H
P
--
K
D
Y
S
Y
F
N
T
L
S
T
K
L
G
W
S
K
K
L
F
---
31
HHSearch
67.11
28%
-118
- C6 -
2AN1
-
NADK_SALTY
A:
[4-289]
------------------------------
H
F
K
C
I
G
I
V
G
H
--------
T
T
H
E
M
L
Y
R
W
L
-
C
D
Q
--
G
Y
E
V
I
V
E
Q
Q
I
A
H
E
---------------
L
Q
----
L
K
---
N
V
P
-
T
G
T
L
A
E
I
G
Q
Q
A
D
L
A
V
V
V
G
G
D
G
N
M
L
G
A
A
R
T
L
--
A
R
--
Y
D
I
N
-
V
I
-
G
I
N
R
G
N
L
G
F
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
--
E
K
R
F
L
L
E
A
Q
V
C
Q
---
Q
------
R
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
E
T
F
A
F
S
Q
R
S
D
G
L
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
P
-
I
L
T
P
S
L
D
A
I
-
T
L
-----
V
P
M
F
P
H
T
L
S
-----
A
R
P
L
V
I
N
S
S
S
T
I
R
L
-
R
F
S
H
---------
D
-
L
E
I
S
C
D
S
Q
I
A
L
P
I
Q
E
G
E
D
V
L
I
R
R
C
D
-------
Y
H
L
N
L
-------
I
H
P
--
K
D
Y
S
Y
F
N
T
L
S
T
K
L
G
W
S
K
------
27
HHSearch
65.09
26%
-102
- C6 -
3PFN
12
NADK_HUMAN
A:
[36-360]
-----------------------------
K
S
P
K
S
V
L
V
I
K
K
M
-
R
D
A
S
L
L
Q
P
F
K
E
L
C
T
H
L
-
M
E
E
--
N
M
I
V
Y
V
E
K
K
V
L
E
D
P
-------
A
I
A
S
D
ES
F
G
----
A
V
K
K
K
F
C
T
F
R
E
D
Y
D
D
I
S
N
Q
I
D
F
I
I
C
L
G
G
D
G
T
L
L
Y
A
S
S
L
F
--
Q
G
--
S
V
P
P
-
V
M
-
A
F
H
L
G
S
L
G
F
L
T
P
F
S
F
E
N
F
Q
S
Q
V
T
Q
V
I
E
G
N
A
A
V
--
V
L
R
S
R
L
K
V
R
V
V
-------
K
-
Q
A
M
Q
Y
Q
V
L
N
E
V
V
I
D
R
G
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
H
L
I
T
T
V
Q
G
D
G
V
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
A
G
A
S
-
M
I
H
P
N
V
P
A
I
-
M
I
-----
T
P
I
C
P
H
S
L
S
-----
F
R
P
I
V
V
P
A
G
V
E
L
K
I
-
M
L
S
P
E
A-----
R
N
T
-
A
W
V
S
F
D
G
R
K
R
Q
E
I
R
H
G
D
S
I
S
I
T
T
S
C
-------
Y
P
L
P
S
-------
I
C
V
RD
P
V
S
D
W
F
E
S
L
A
Q
C
L
H
---------
33
HHSearch
63.63
26%
-116
- C6 -
1YT5
7
NADK_THEMA
A:
[1-255]
--------------------------------
M
K
I
A
I
L
Y
R
E
-
E
R
E
K
---
E
G
E
F
L
K
E
K
I
-
S
K
---
E
H
E
V
I
E
--
F
G
-
E
----------------
A
-----------------
N
A
P
G
R
V
T
A
D
L
I
V
V
V
G
G
D
G
T
V
L
K
A
A
K
K
A
--
A
---
D
G
T
P
-
M
V
-
G
F
K
A
G
R
L
G
F
L
T
S
Y
T
L
D
E
I
D
R
F
L
E
D
L
R
N
W
N
F
R
E
--
E
T
R
W
F
I
Q
I
E
S
E
L
----------
G
N
H
L
A
L
N
D
V
T
L
E
R
D
L
S
G
K
M
V
E
I
E
V
E
V
E
H
H
S
S
M
W
F
F
A
D
G
V
V
I
S
T
P
T
G
S
T
A
Y
S
L
S
I
G
G
P
-
I
I
F
P
E
C
E
V
L
-
E
I
-----
S
P
I
A
P
Q
F
F
L
-----
T
R
S
V
V
I
P
S
N
F
K
V
V
V
-
E
S
Q
---------
R
D
-
I
N
M
L
V
D
G
V
L
T
G
K
---
T
K
R
I
E
V
K
K
S
R
-------
R
Y
V
R
I
-------
L
R
P
--
P
E
Y
D
Y
V
T
V
I
R
D
K
L
G
Y
G
R
------
32
HHSearch
61.67
22%
-107
- C6 -
2I2C
2
NADK1_LISMO
A:
[1-264]
--------------------------------
M
K
Y
M
I
T
S
K
G
-
D
E
K
S
D
-
L
L
R
L
N
M
I
A
G
F
-
G
E
Y
--
D
M
E
Y
---------------------------------------------
D
D
V
E
P
E
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
--
E
E
RL
D
E
I
A
-
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
A
K
G
E
Y
Q
K
--
V
S
Y
P
L
L
K
T
T
V
K
Y
---
G
I
G
K
-
K
E
A
T
Y
L
A
L
N
E
S
T
V
K
S
S
--
G
G
P
F
V
V
D
V
V
I
N
D
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
-
Q
L
-----
T
E
M
A
S
I
N
N
R
VYRTI
G
S
P
L
V
F
P
K
H
H
V
V
S
L
-
Q
P
V
N
-------
D
K
D
-
F
Q
I
S
V
D
H
L
S
I
L
-
H
R
D
V
Q
E
I
R
Y
E
V
S
A
-------
K
K
I
H
F
-------
A
R
F
--
R
S
F
P
F
W
R
R
V
H
D
S
F
I
E
D
-------
49
Fugue
60.94
24%
-100
- C6 -
3PFN
14
NADK_HUMAN
A:
[6-361]
TTFGPK
A
C
V
L
QNPQT
I
M
H
I
Q
DPAS
Q
R
L
T
W
N
K
S
P
K
S
V
L
V
I
K
K
M
R
D
A
S
L
L
Q
P
F
K
E
L
C
T
H
L
M
E
E
N
M
-
I
V
Y
V
E
---
K
K
V
L
E
D
P
A
I
A
S
D
E
S
F
G
A
V
--
K
K
----
K
F
---
C
T
F
-
R
E
D
Y
D
D
I
S
N
Q
I
D
F
I
I
C
L
G
G
D
G
T
L
L
Y
A
S
S
L
F
--
Q
G
---
S
V
P
-
P
V
M
A
F
H
L
G
S
L
G
F
L
T
P
F
S
F
E
N
F
Q
S
Q
V
T
Q
V
I
E
G
N
A
A
V
--
V
L
R
S
R
L
K
V
R
V
V
K
---
Q
A
M
Q
-----
Y
Q
V
L
N
E
V
V
I
D
R
G
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
H
L
I
T
T
V
Q
G
D
G
V
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
A
G
A
S
M
I
-
H
P
N
V
P
A
I
M
I
------
T
P
I
C
P
H
S
L
S
-----
F
R
P
I
V
V
P
A
G
V
E
L
K
I
M
L
S
P
E
A
------
R
N
T
-
A
W
V
S
F
D
G
R
K
R
Q
E
I
R
H
G
D
S
I
S
I
T
T
S
C
-------
Y
P
L
P
S
-------
I
C
V
--
R
D
P
V
S
D
W
F
E
S
L
A
Q
C
L
H
H
------
47
Fugue
60.15
26%
-113
- C6 -
1SUW
2
NADK_ARCFU
A:
[1-249]
---------------------------------
M
R
A
A
V
V
Y
K
-
T
D
G
H
V
K
R
I
E
E
A
L
K
R
------------------------------------
L
E
----
V
E
---
V
E
L
-
F
N
Q
P
S
E
E
L
E
N
F
D
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
--
K
R
---
C
P
P
-
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
A
S
P
E
N
F
E
V
E
L
K
K
A
V
E
K
-
F
E
V
--
E
R
F
P
R
V
S
C
----------
S
-
A
M
P
D
V
L
A
L
N
E
I
A
V
L
S
R
K
P
A
K
M
I
D
V
A
L
R
V
D
G
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
-
I
L
-----
I
P
I
A
P
F
R
F
G
-----
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
E
----------
K
-
A
I
V
V
A
D
G
Q
K
S
V
D
F
D
--
G
E
I
T
I
E
K
S
E
-------
F
P
A
V
F
-------
F
K
----
N
E
K
R
F
R
N
L
F
G
K
V
-----
R
S
I
G
-
6
PsiBlast_PDB
59.63
33%
-113
- C6 -
2AN1
-
NADK_SALTY
A:
[65-290]
----------------------------------------------------------------------------------------------------------------------
D
L
A
V
V
V
G
G
D
G
N
M
L
G
A
A
R
T
L
--
A
R
--
Y
D
I
N
-
V
I
-
G
I
N
R
G
N
L
G
F
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
R
Y
I
S
--
E
K
R
F
L
L
E
A
Q
V
C
Q
---
Q
------
R
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
E
T
F
A
F
S
Q
R
S
D
G
L
I
I
S
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
P
-
I
L
T
P
S
L
D
A
I
-
T
L
-----
V
P
M
F
P
H
T
L
S
-----
A
R
P
L
V
I
N
S
S
S
T
I
R
L
-
R
F
S
H
---------
D
-
L
E
I
S
C
D
S
Q
I
A
L
P
I
Q
E
G
E
D
V
L
I
R
R
C
D
-------
Y
H
L
N
L
-------
I
H
P
--
K
D
Y
S
Y
F
N
T
L
S
T
K
L
-----
G
W
S
K
K
28
HHSearch
59.47
23%
-102
- C6 -
3AFO
3
POS5_YEAST
A:
[40-377]
------------------------------
P
L
Q
N
V
Y
I
T
K
K
P
-
W
T
P
S
T
R
E
A
M
V
E
F
I
T
H
L
-
H
E
S
YP
E
V
N
V
I
V
Q
P
D
V
A
E
E
-----
I
S
Q
-
D
F
K
S
P-
L
E
NDPN
R
P
H
--
I
L
Y
-
T
G
P
E
Q
D
I
V
N
R
T
D
L
L
V
T
L
G
G
D
G
T
I
L
H
G
V
S
M
F
--
G
N
T-
Q
V
P
P
-
V
L
-
A
F
A
L
G
T
L
G
F
L
S
P
F
D
F
K
E
H
K
K
V
F
Q
E
V
I
S
S
R
A
K
C
--
L
H
R
T
R
L
E
C
H
L
K
K
---
K
D
-
S
N
S
S
I
V
T
H
A
M
N
D
I
F
L
H
R
G
N
S
P
H
L
T
N
L
D
I
F
I
D
G
E
F
L
T
R
T
T
A
D
G
V
A
L
A
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
S
-
I
V
S
P
L
V
P
A
I
-
L
M
-----
T
P
I
C
P
R
S
L
S
-----
F
R
P
L
I
L
P
H
S
S
H
I
R
I
-
K
I
G
S
K
LNQKPV
N
S
V
-
V
K
L
S
V
D
G
I
P
Q
Q
D
L
D
V
G
D
E
I
Y
V
I
N
E
V
G
T
I
Y
I
DG
T
----KR
S
G
I
Y
C
V
A
K
--
T
E
N
D
W
I
R
G
I
N
E
L
L
G
F
N
S
S
-----
22
PsiBlast_CBE
59.28
33%
-112
- C6 -
4HAO
8
NADK_YERPE
B:
[65-291]
---------------------------------------------------------------------------------------------------------------------
A
D
L
A
V
V
V
G
G
D
G
N
M
L
G
A
A
R
V
L
--
A
R
--
Y
D
I
K
-
V
I
-
G
V
N
R
G
N
L
G
F
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
E
Y
L
S
--
E
Q
R
F
L
L
E
T
H
V
R
----------
S
R
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
D
R
F
A
F
S
Q
R
S
D
G
L
I
I
A
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
P
-
I
L
T
P
T
L
D
A
I
-
V
L
-----
V
P
M
F
P
H
T
L
T
-----
A
R
P
L
V
I
S
S
S
S
T
I
R
L
-
K
F
S
H
I
------
T
S
D
-
L
E
I
S
C
D
S
Q
I
A
L
P
I
Q
E
G
E
E
V
L
I
R
R
S
D
-------
F
H
L
N
L
-------
I
H
P
--
K
D
Y
S
Y
F
N
T
L
S
T
K
L
-----
G
W
S
K
K
30
HHSearch
58.96
26%
-120
- C6 -
1Z0S
3
NADK_ARCFU
A:
[30-276]
--------------------------------
M
R
A
A
V
V
Y
K
T
-
D
G
-----
H
V
K
R
I
E
E
A
L
-
K
R
L
--
E
V
E
V
E
L
F
N
Q
P
-------------------------------------
S
E
E
L
E
N
F
D
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
--
K
---
R
C
P
P
-
I
F
-
G
I
N
T
G
R
V
G
L
L
T
H
A
S
P
E
N
F
E
V
E
L
K
K
A
V
E
-
K
F
E
V
--
E
R
F
P
R
V
S
C
S
A
M
-----------
P
D
V
L
A
L
N
E
I
A
V
L
S
R
K
P
A
K
M
I
D
V
A
L
R
V
D
G
V
E
V
D
R
I
R
C
D
G
F
I
V
A
T
Q
I
G
S
T
G
Y
A
F
S
A
G
G
P
-
V
V
E
P
Y
L
E
C
F
-
I
L
-----
I
P
I
A
P
F
R
F
G
-----
W
K
P
Y
V
V
S
M
E
R
K
I
E
V
-
I
A
----------
E
K
-
A
I
V
V
A
D
G
Q
K
S
V
D
--
F
D
G
E
I
T
I
E
K
S
E
-------
F
P
A
V
F
-------
F
K
N
--
E
--
K
R
F
R
N
L
F
G
K
V
R
S
--------
5
PsiBlast_PDB
58.24
33%
-113
- C6 -
4HAO
3
NADK_YERPE
A:
[65-291]
---------------------------------------------------------------------------------------------------------------------
A
D
L
A
V
V
V
G
G
D
G
N
M
L
G
A
A
R
V
L
--
A
R
--
Y
D
I
K
-
V
I
-
G
V
N
R
G
N
L
G
F
L
T
D
L
D
P
D
N
A
L
Q
Q
L
S
D
V
L
E
G
E
Y
L
S
--
E
Q
R
F
L
L
E
T
H
V
R
----------
S
R
I
S
T
A
I
N
E
V
V
L
H
P
G
K
V
A
H
M
I
E
F
E
V
Y
I
D
D
R
F
A
F
S
Q
R
S
D
G
L
I
I
A
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
P
-
I
L
T
P
T
L
D
A
I
-
V
L
-----
V
P
M
F
P
H
T
L
T
-----
A
R
P
L
V
I
S
S
S
S
T
I
R
L
-
K
F
S
H
I
------
T
S
D
-
L
E
I
S
C
D
S
Q
I
A
L
P
I
Q
E
G
E
E
V
L
I
R
R
S
D
-------
F
H
L
N
L
-------
I
H
P
--
K
D
Y
S
Y
F
N
T
L
S
T
K
L
-----
G
W
S
K
K
17
PsiBlast_PDB
54.15
27%
-110
- C6 -
2I1W
7
NADK1_LISMO
A:
[37-261]
----------------------------------------------------------------------------------------------------------------------
E
I
V
I
S
I
G
G
D
G
T
F
L
S
A
F
H
Q
Y
EE
R
L
--
D
E
I
A
-
F
I
-
G
I
H
T
G
H
L
G
F
Y
A
D
W
R
P
A
E
A
D
K
L
V
K
L
L
A
K
G
E
Y
Q
K
--
V
S
Y
P
L
L
K
T
T
V
K
Y
--------
K
E
A
T
Y
L
A
L
N
E
S
T
V
K
S
S
--
P
F
V
V
D
V
V
--
I
N
D
I
H
F
E
R
F
R
G
D
G
L
C
M
S
T
P
S
G
T
T
A
Y
N
K
S
L
G
G
A
-
L
M
H
P
S
I
E
A
M
-
Q
L
T
E
M
AS
I
N
N
R
V
Y
R
T
I
-----
G
S
P
L
V
F
P
K
H
H
V
V
S
L
-
Q
P
V
N
D
------
K
-
D
-
F
Q
I
S
V
D
-
H
L
S
I
L
H
R
D
V
Q
E
I
R
Y
E
V
S
A
-------
K
K
I
H
F
-------
A
R
F
--
R
S
F
P
F
W
R
R
V
H
D
S
F
----------
13
PsiBlast_PDB
53.88
30%
-115
- C6 -
3PFN
10
NADK_HUMAN
A:
[106-333]
------------------------------------------------------------------------------------------------------------------
S
N
Q
I
D
F
I
I
C
L
G
G
D
G
T
L
L
Y
A
S
S
L
F
--
Q
G
--
S
V
P
P
-
V
M
-
A
F
H
L
G
S
L
G
F
L
T
P
F
S
F
E
N
F
Q
S
Q
V
T
Q
V
I
E
G
N
A
A
V
V
L
R
S
R
L
K
V
R
V
V
---------
K
-
Q
A
M
Q
Y
Q
V
L
N
E
V
V
I
D
R
G
P
S
S
Y
L
S
N
V
D
V
Y
L
D
G
H
L
I
T
T
V
Q
G
D
G
V
I
V
S
T
P
T
G
S
T
A
Y
A
A
A
A
G
A
S
-
M
I
H
P
N
V
P
A
I
-
M
I
-----
T
P
I
C
P
H
S
L
S
-----
F
R
P
I
V
V
P
A
G
V
E
L
K
I
-
M
L
S
P
E
------
A
R
N
T
A
W
V
S
F
D
G
R
K
R
Q
E
I
R
H
G
D
S
I
S
I
T
--------------------------------------------------
26
PsiBlast_CBE
49.87
31%
-119
- C6 -
3AFO
3
POS5_YEAST
B:
[108-320]
--------------------------------------------------------------------------------------------------------------
E
Q
D
I
V
N
R
T
D
L
L
V
T
L
G
G
D
G
T
I
L
H
G
V
S
M
F
--
G
N
--
T
Q
V
P
P
V
L
-
A
F
A
L
G
T
L
G
F
L
S
P
F
D
F
K
E
H
K
K
V
F
Q
E
V
I
S
S
R
A
K
C
--
L
H
R
T
R
L
E
C
H
L
K
K
KDS
N
S
-
S
-
I
V
T
H
--
A
M
N
D
I
F
L
H
R
G
N
S
P
H
L
T
N
L
D
I
F
I
D
G
E
F
L
T
R
T
T
A
D
G
V
A
L
A
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
S
-
I
V
S
P
L
V
P
A
I
-
L
M
-----
T
P
I
C
P
R
S
L
S
-----
F
R
P
L
I
L
P
H
S
S
H
I
R
I
-
K
I
-------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.43
31%
-110
- C6 -
3AFO
3
POS5_YEAST
A:
[108-304]
--------------------------------------------------------------------------------------------------------------
E
Q
D
I
V
N
R
T
D
L
L
V
T
L
G
G
D
G
T
I
L
H
G
V
S
M
F
--
G
N
--
T
Q
V
P
P
V
L
-
A
F
A
L
G
T
L
G
F
L
S
P
F
D
F
K
E
H
K
K
V
F
Q
E
V
I
S
S
R
A
K
C
--
L
H
R
T
R
L
E
C
H
L
K
K
KDS
N
S
-
S
-
I
V
T
H
--
A
M
N
D
I
F
L
H
R
G
N
S
P
H
L
T
N
L
D
I
F
I
D
G
E
F
L
T
R
T
T
A
D
G
V
A
L
A
T
P
T
G
S
T
A
Y
S
L
S
A
G
G
S
-
I
V
S
P
L
V
P
A
I
-
L
M
-----
T
P
I
C
P
R
S
L
S
-----
F
R
P
L
I
L
P
H
S
S
H
I
R
I
-
K
I
-------------------------------------------------------------------------------------