@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1696: (2016-05-04 )
MLTELRIESLGAISVATAEFDRGFTVLTGETGTGKTMVVTGLHLLGGARADATRVRSGADRAVVEGRFTTTDLDDATVAGLQAVLDSSGAERDEDGSVIALRSISRDGPSRAYLGGRGVPAKSLSGFTNELLTLHGQNDQLRLMRPDEQRGALDRFAAAGEAVQRYRKLRDAWLTARRDLVDRRNRARELAQEADRLKFALNEIDTVDPQPGEDVALVADIARLSELDTLREAATTARATLCGTPDADAFDRGAVDSLGRARAALQSSDDAALRGLAEQVGEALTVVVDAVAELGAYLDELPADASALDAKLARQAQLRTLTRKYAADIDGVLRWADEARARLAQLDVSEEGLAALERRTGELAHELGQAAVDLSTIRRKAAKRLAKEVSAELSALAMADAEFTIGVTTELADHGDPVALALASGELARAGADGVDAVEFGFVAHRGMTVLPLAKSASGGELSRVMLSLEVVLATSRKQAAGTTMVFDEIDAGVGGWAAVQIGRRLARLARTHQVIVVTHLPQVAAYADVHLMVQRTGRDGASGVRRLTSEDRVAELARMLAGLGDSDSGRAHARELLETAQNDELT
Atome Classification :
(20 SA)
---....-.....10.-----...--...--.20........30........40....-------....----50.--------.......--60........---70...--.....80........90........100-.......110.......120.......130-----.......--.--140-........150.......160.......170.......180....----...190.......200.....---..210.......220....-----...230.......240.......250-........260.......--270.......280.-......290.......300.---......310.......320....---...330.......340-.......350-........360.....----..370.......--380--------...------....390.......----------------400.......410..--.....420.......430...---....440.......-.450.-------......460----.......470-------.........480.......490--....------------------...500.......510--..--.....520.......--530.......-540--........550.....------..560...-----....570.......580.....------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---ML
T
E
-
L
R
I
ESLG
A
-----
I
S
V
--
A
T
A--EFDR
G
F
T
V
L
TGETGTG
K
T
M
V
V
T
G
L
H
LL-------GGAR----A
D
A
--------
T
R
VRSGA--D
R
A
V
V
EGRFT---TTDLD--
D
A
T
V
A
G
L
Q
A
V
L
DSSGAERDEDG
S
V
I
A
L
R-SISRDGPSRAYLGGRGV
P
A
K
S
L
S
G
F
T
N
E
L
------
L
T
LHGQN--D--
Q
L
--
R
L
MRP
D
E
QR
G
A
L
D
R
F
A
A
A
G
E
A
V
Q
R
Y
R
K
L
R
D
A
W
L
T
A
R
R
D
L
V
D
R
R
N
R
----
A
R
E
L
A
Q
E
A
D
R
L
K
F
A
L
NEIDTV---DPQPGE
D
V
A
L
V
A
D
I
A
R
L
S
E
-----
L
D
T
L
R
E
A
A
T
T
A
R
A
TLCGTPD
A
D
A
F
D
--
R
G
A
V
D
S
L
G
R
A
R
A
ALQSS
D
--
D
A
A
L
R
G
L
A
E
Q
V
G
E
A
-
L
T
V
V
V
D
A
V
A
E
L
G
A
Y
L
D
ELPA---
D
A
S
A
L
D
A
K
L
A
R
Q
A
Q
L
R
T
L
T
R
K
Y
A
---
A
D
I
D
G
V
L
R
W
A
D
E
A
R
A
R
-
L
A
QLDVS
E
E
--
G
L
A
A
L
E
R
R
T
G
E
L
A
H
E
L
----
G
Q
A
A
V
D
L
S
T
I
R
R
--
K
A
A
--------
K
R
L
------
A
K
E
V
S
A
E
L
S
A
L
AMA----------------D
A
E
F
T
I
G
V
T
TELADH--GD
P
V
A
L
A
LASG
E
L
A
RAGADGV---
D
A
V
E
F
-
G
F
V
AHRG
M
-
T
V
L
P
L
-------AKSASG
G
E
L
----
S
R
V
M
L
S
L
E
---------
V
V
L
ATSRKQAAG
T
T
M
V
F
DEIDA--GVG
G
------------------
W
A
A
V
Q
I
G
R
R
L
A
R
L
ART--
H
Q
--
V
I
V
V
THLP
Q
V
A
A
Y
A
D
--
V
H
L
M
V
Q
RTGR-D-
G
--
A
S
G
V
R
R
LTS
E
D
R
V
A
E
L
------
A
R
M
L
A
GLG-----DSDS
G
R
A
H
A
R
E
L
L
E
T
AQNDELT------------
26
HHSearch
94.76
36%
-83
- C4 -
4AD8
-
?
A:
[33-563]
---
R
L
S
R
-
L
E
I
R
N
L
A
T
-----
I
T
Q
--
L
E
L
--
E
L
G
G
G
F
C
A
F
T
G
E
T
G
A
G
K
S
I
I
V
D
A
L
G
L
L
-------
L
G
G
R
----
A
N
H
--------
D
L
I
R
S
G
E
--
K
E
L
L
V
T
G
F
W
----------------------------------
D
S
A
S
R
-
R
L
S
S
A
G
R
G
A
A
R
L
S
G
E
V
V
S
V
R
E
L
Q
E
W
A
Q
G
R
------
L
T
I
H
W
Q
H
--
S
--
A
V
--
S
L
L
S
P
A
N
Q
R
G
L
L
D
R
R
V
T
K
E
--
A
Q
A
Y
A
A
A
H
A
A
W
R
E
A
V
S
R
L
E
R
L
Q
A
S
----
Q
R
E
R
A
R
Q
I
D
L
L
A
F
Q
V
Q
E
I
S
E
V
---
S
P
D
P
G
E
E
E
G
L
N
T
E
L
S
R
L
S
N
-----
L
H
------------------------------------------------------------------------------------
P
E
A
L
D
R
V
E
A
R
L
S
A
L
S
K
L
K
N
K
Y
G
---
P
T
L
E
D
V
V
E
F
G
A
Q
A
A
E
E
-
L
A
G
L
E
E
D
E
R
--
D
A
G
S
L
Q
A
D
V
D
A
L
H
A
E
L
----
L
K
V
G
Q
A
L
D
A
A
R
E
--
R
E
A
--------
E
P
L
------
V
D
S
L
L
A
V
I
R
E
L
G
M
P
----------------
H
A
R
M
E
F
A
L
S
A
L
A
E
-------------------
P
A
A
Y
G
L
---
S
D
V
L
L
-
R
F
S
A
N
P
G
E
-
E
L
G
P
L
-------
S
D
V
A
S
G
G
E
L
----
S
R
V
M
L
A
V
S
---------
T
V
L
G
A
-----
D
T
P
S
V
V
F
D
E
V
D
A
--
G
I
G
G
------------------
A
A
A
I
A
V
A
E
Q
L
S
R
L
A
D
T
--
R
Q
--
V
L
V
V
T
H
L
A
Q
I
A
A
R
A
H
--
H
H
Y
K
V
E
K
Q
V
E
D
G
R
T
--
V
S
H
V
R
L
L
T
G
D
E
R
L
E
E
I
------
A
R
M
L
S
G
N
T
------
S
E
A
A
L
E
H
A
R
E
L
L
A
--------------------
1
PsiBlast_PDB
90.21
31%
-87
- C4 -
4AD8
-
?
A:
[34-562]
----
L
S
R
-
L
E
I
R
N
L
A
T
-----
I
T
Q
--
L
E
L
--
E
L
G
G
G
F
C
A
F
T
G
E
T
G
A
G
K
S
I
I
V
D
A
L
G
L
L
-------
L
G
G
R
----
A
N
H
--------
D
L
I
R
S
G
E
--
K
E
L
L
V
T
G
F
W
-------------
D
S
A
S
---------------------
R
-
R
L
S
S
A
G
R
G
A
A
R
L
S
G
E
V
V
S
V
R
E
L
Q
E
W
A
Q
G
R
------
L
T
I
H
W
Q
H
--
S
--
A
V
--
S
L
L
S
P
A
N
Q
R
G
L
L
D
R
------
R
V
T
K
E
A
Q
A
Y
A
A
A
H
A
A
W
R
E
A
V
S
R
L
E
R
L
Q
A
S
Q
R
E
R
A
R
Q
I
D
L
L
A
F
Q
V
Q
E
I
S
E
V
---
S
P
D
P
G
E
E
E
G
L
N
T
E
L
S
R
L
S
N
-----
L
H
-------------------------
P
E
A
L
D
---
R
V
E
A
R
L
-------
S
A
L
S
K
L
K
N
K
Y
G
P
T
-
L
E
D
V
V
----
E
F
G
A
-----------------------------------------------
Q
A
A
E
E
-
L
A
G
L
E
E
D
E
R
--
D
A
G
S
L
Q
A
D
V
D
A
L
H
A
E
L
----
L
K
V
G
Q
A
L
D
A
A
R
E
--
R
E
A
--------
E
P
L
------
V
D
S
L
L
A
V
I
R
E
L
G
M
P
----------------
H
A
R
M
E
F
A
L
S
A
-------------------
L
A
E
P
A
A
Y
G
L
---
S
D
V
L
L
-
R
F
S
A
N
P
G
E
-
E
L
G
P
L
-------
S
D
V
A
S
G
G
E
L
----
S
R
V
M
L
A
V
S
---------
T
V
L
G
-----
A
D
T
P
S
V
V
F
D
E
V
D
A
--
G
I
G
G
------------------
A
A
A
I
A
V
A
E
Q
L
S
R
L
A
D
T
--
R
Q
--
V
L
V
V
T
H
L
A
Q
I
A
A
R
A
H
--
H
H
Y
K
V
E
K
Q
V
E
-
D
-
G
R
T
V
S
H
V
R
L
L
T
G
D
E
R
L
E
E
I
------
A
R
M
L
S
G
-
N
-----
T
S
E
A
A
L
E
H
A
R
E
L
L
---------------------
48
Fugue
59.79
14%
-43
* C5 *
4UX3
2
SMC3_YEAST
A:
[3-527]
---
Y
I
K
R
-
V
I
I
K
G
F
K
T
-----
Y
R
N
--
E
T
I
I
D
N
F
S
P
H
Q
N
V
I
I
G
S
N
G
S
G
K
S
N
F
F
A
A
I
R
F
V
LSDDYSN
L
K
R
E
----
E
R
Q
--------
G
L
I
H
Q
G
S
--
G
G
S
V
M
S
A
S
V
E
---
I
V
I
R
R
--
T
V
G
L
K
K
D
D
Y
Q
L
N
D
R
N
V
T
K
G
D
I
V
R
M
L
E
T
A
-
G
F
S
M
N
N
P
Y
N
I
V
P
Q
G
K
I
V
A
L
T
N
A
K
D
K
E
R
L
Q
------
L
L
E
D
V
V
G
--
A
--
K
S
--
F
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
----
Y
N
E
L
E
R
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
-------------------------------------------------------------------------------------------------------------------
L
N
E
V
I
N
Q
M
E
T
S
D
Q
L
L
Q
R
L
N
D
M
N
---
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
N
-
F
K
K
F
N
E
R
R
K
--
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
----
Q
D
L
I
V
K
L
K
Q
Q
K
V
--
N
A
V
--------
D
S
T
------
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
----------------
L
---------------------
V
P
R
G
T
A
K
L
I
I
H
S
-------
I
S
V
S
F
-
N
S
K
Q
N
E
Q
L
-
H
V
E
Q
L
-------------
S
G
G
----
Q
K
T
V
C
A
I
A
---------
L
I
L
A
I
Q
M
V
D
P
A
-
S
F
Y
L
F
D
E
I
D
A
--
A
L
D
K
------------------
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
--
A
Q
--
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
--
K
F
F
R
V
K
Y
E
N
K
------
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
------
R
----------------------------------------------
53
Fugue
49.46
15%
-17
- C5 -
3J16
4
RLI1_YEAST
B:
[1-608]
---
M
S
D
K
N
S
R
I
A
I
V
S
A
-----
D
K
C
--
K
P
K
--
K
C
R
Q
E
C
K
R
S
C
P
V
V
K
T
G
K
L
C
I
E
V
T
P
T
---------
S
K
I
A
----
F
I
S
--------
E
I
L
C
I
G
C
--
G
I
C
V
K
K
C
P
F
--------
D
--
A
I
Q
I
I
N
L
P
T
N
L
E
A
H
V
T
H
R
Y
S
A
N
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
------
G
K
S
T
A
L
------
K
I
L
A
G
K
Q
KP
N
--
L
G
--
R
F
D
D
P
P
E
W
Q
E
I
I
K
Y
F
R
G
-
S
E
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
D
N
I
----
P
R
A
I
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
E
K
---
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V
L
K
RDIEK
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
EP
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
--
L
L
A
P
T
K
Y
V
I
C
V
-
E
H
-
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
---
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
---
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
-
A
D
A
T
E
D
L
Q
N
--
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
----
G
D
F
V
L
N
V
E
E
G
E
F
--
S
D
S
E
I
L
V
M
M
G
E
N
G
T
------
G
K
T
T
L
I
K
L
L
A
G
A
L
K
----------------
P
D
E
G
Q
D
I
P
K
L
N
V
S
M
K
--
P
Q
K
I
A
P
K
F
P
G
T
V
R
Q
L
F
F
K
K
I
R
---
G
Q
F
L
N
-
P
Q
F
Q
T
D
V
V
-
K
P
L
R
I
DDIIDQE
V
Q
H
L
S
G
G
E
L
----
Q
R
V
A
I
V
L
A
---------
L
G
-------
I
P
A
D
I
Y
L
I
D
E
P
S
A
--
Y
L
D
S
------------------
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
--
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
--
D
K
V
I
V
F
-
E
G
I
-
P
-
S
--
K
N
A
H
A
R
-
A
P
E
S
L
L
T
G
C
------
N
R
F
L
K
N
L
N
VTFRR
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
46
Fugue
49.02
31%
-43
- C4 -
4ABX
-
RECN_DEIRA
A:
[-1-360]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
Q
R
E
R
A
R
Q
I
D
L
L
A
F
Q
V
Q
E
I
S
E
V
---
S
P
D
P
G
E
E
E
G
L
N
T
E
L
S
R
L
S
N
-----
L
H
T
I
A
Q
A
A
A
G
G
V
E
L
L
S
D
G
------
D
--
L
N
A
A
G
L
I
G
E
A
V
R
A
L
N
A
G
A
K
Y
D
E
T
V
M
Q
L
Q
N
E
L
R
A
A
-
L
E
S
V
Q
A
I
A
G
E
L
R
D
V
A
E
G
S
A
A
---
D
P
E
A
L
D
R
V
E
A
R
L
S
A
L
S
K
L
K
N
K
Y
G
---
P
T
L
E
D
V
V
E
F
G
A
Q
A
A
E
E
-
L
A
G
L
E
E
D
E
R
--
D
A
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
47.98
12%
-41
- C5 -
3EUJ
2
MUKB_HAEDU
A:
[3-483]
---
M
I
A
R
-
G
K
F
R
S
L
T
L
I
NWNG
F
F
A
--
R
T
F
--
D
F
D
E
L
V
T
T
L
S
G
G
N
G
A
G
K
S
T
T
M
A
G
F
V
T
A
-------
L
I
P
D
----
L
T
L
--------
L
N
F
R
N
T
T
--
E
A
G
S
T
S
S
S
R
D
---
K
G
L
Y
G
--
K
L
K
A
G
V
C
Y
A
V
L
E
T
V
N
S
R
---
A
Q
R
I
I
T
G
V
-
R
L
Q
Q
I
A
G
R
D
-------------
K
K
V
D
I
R
P
------
F
S
L
Q
N
V
P
--
M
--
T
------------------------------------
D
S
V
I
S
L
F
T
E
Q
V
A
----
N
K
A
R
V
L
S
L
N
D
L
K
E
K
F
E
E
T
A
V
T
---
F
K
P
Y
H
S
I
T
D
Y
H
S
F
M
F
D
L
G
-----------------------------
I
L
--
P
K
R
L
R
S
S
S
D
R
N
K
F
Y
K
L
I
E
--
A
S
L
Y
G
G
I
S
S
V
I
T
K
S
-
L
R
D
Y
L
L
P
E
N
S
G
V
R
-------------------
Q
A
F
Q
D
A
E
S
V
A
N
I
L
R
---
K
T
I
Q
R
E
Q
N
R
I
L
Q
L
N
Q
G
-
L
Q
N
I
A
F
G
Q
V
--
K
G
V
R
L
V
V
N
I
R
D
T
H
S
I
L
----
L
N
A
L
S
D
-----
Q
--
S
F
S
--------
E
A
L
------
A
M
L
Y
K
R
I
G
E
E
L
L
D
Y
----------------
R
N
Y
L
D
L
E
V
E
T
L
R
G
A
Y
--
G
W
M
R
A
E
S
S
A
L
S
T
G
E
A
I
G
T
G
M
S
---
I
L
L
M
V
-
V
Q
S
W
E
E
E
S
-
R
R
M
--------------------------------------------
R
A
K
D
I
L
P
C
R
L
L
F
L
D
Q
A
A
--
R
L
D
A
------------------
M
S
I
N
T
L
F
E
L
C
E
R
L
-----
D
M
--
Q
L
L
I
A
A
P
E
N
I
S
P
E
R
G
--
T
T
Y
K
L
V
R
K
I
L
-
A
-
N
--
Q
E
Y
V
-----------
H
------
V
V
G
L
K
G
F
G
---------------------------------------
47
Fugue
47.74
13%
-42
- C5 -
1E69
-
?
A:
[1-1164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
K
K
L
Y
L
K
GF
K
S
F
G
R
P
S
L
I
G
F
S
D
R
V
T
A
I
V
G
P
N
G
SGK
S
N
I
I
D
A
I
K
W
V
F
G
E
K
F
D
-
M
I
F
A
G
S
E
N
L
--
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
----
E
E
I
T
V
A
R
E
L
K
R
T
--
G
E
N
--------
T
Y
Y
------
L
N
G
S
P
V
R
L
K
D
I
R
D
R
----------------
F
A
G
T
G
L
G
V
D
F
Y
S
I
V
G
--
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
F
---
I
S
L
L
F
F
G
G
E
G
R
L
E
I
-
S
I
R
K
P
-------
G
R
R
D
Q
K
L
S
L
LS
G
G
E
K
A
L
V
G
L
A
---------
L
L
F
A
L
M
E
I
K
P
S
-
P
F
Y
V
L
D
E
V
D
S
--
P
L
D
D
------------------
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
--
T
Q
--
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
--
L
L
H
G
V
T
M
--
V
-
N
-
G
--
V
S
A
I
V
P
V
E
V
------------------------------------------------------------
3
PsiBlast_PDB
46.66
31%
-29
- C4 -
4ABX
-
RECN_DEIRA
A:
[-1-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
R
E
R
----
A
R
Q
I
----
D
L
L
A
F
Q
V
Q
E
I
S
E
V
---
S
P
D
P
G
E
E
E
G
L
N
T
E
L
S
R
L
S
N
-----
L
H
T
I
A
Q
A
A
A
G
G
V
E
L
L
S
---
D
G
D
L
N
A
--
A
G
L
I
G
E
A
V
R
A
L
N
A
G
A
K
Y
D
--
E
T
V
M
Q
-
L
Q
N
E
L
R
A
A
-
L
E
S
V
Q
A
I
A
G
E
L
R
D
V
A
E
G
S
A
A
---
D
P
E
A
L
D
R
V
E
A
R
L
S
A
L
S
K
L
K
N
K
Y
G
---
P
T
L
E
D
V
V
E
F
G
A
Q
A
A
E
E
-
L
A
G
L
E
E
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
44.95
11%
-32
- C2 -
1BVZ
-
NEPU2_THEVU
A:
[1-585]
--M
L
L
E
A
-
I
F
H
E
A
K
G
S
-----
Y
A
Y
--
P
I
S
--
E
T
Q
L
R
V
R
L
R
A
K
K
G
D
V
V
R
C
E
V
L
Y
A
------------------------------
D
R
Y
A
S
P
----
E
E
E
L
A
H
A
L
A
---
G
K
A
G
S
--
D
E
R
F
D
Y
F
E
A
L
L
E
C
------
S
T
K
R
V
K
Y
V
F
-
L
L
T
G
P
Q
G
E
A
V
Y
F
G
E
T
G
F
S
A
E
R
S
---
K
A
G
V
------
F
Q
Y
A
Y
I
H
--
R
--
S
E
--
V
F
T
T
P
E
W
A
K
E
A
V
-----------
I
Y
Q
I
F
P
E
R
F
A
N
G
D
P
S
N
D
P
P
G
T
E
----
Q
W
A
K
D
A
R
P
R
H
D
S
F
Y
G
-------------
G
D
L
K
G
V
I
D
R
L
P
Y
L
E
E
-----
L
G
V
---------
T
A
L
Y
F
T
P
I
F
A
S
P
S
--
H
H
K
Y
D
T
A
D
Y
L
A
I
D
P
Q
F
G
D
--
L
P
T
F
R
R
L
V
D
E
A
H
R
R
G
I
K
I
I
L
D
A
V
F
N
H
A
G
D
Q
F
F
A
F
R
---
D
V
L
Q
K
G
E
Q
S
R
Y
K
D
W
F
F
I
E
D
F
P
V
S
---
K
T
S
R
T
N
Y
E
T
F
A
V
Q
V
P
A
-
M
P
K
L
R
T
E
N
P
--
E
V
K
E
Y
L
F
D
V
A
R
F
W
M
E
-
Q
GID
G
W
R
L
D
V
A
N
E
V
D
H
--
A
F
W
--------
R
E
F
------
R
R
L
V
K
S
L
N
P
D
A
L
I
V
G
E
I
WHDASGWLMGDQF
D
S
V
M
N
Y
L
F
R
E
S
V
I
R
F
FA
T
G
E
I
H
A
E
R
F
D
A
E
L
T
R
A
R
M
L
Y
P
---
E
Q
A
A
Q
-
G
L
W
N
L
L
D
S
-
H
D
T
E
R
-------
F
L
T
S
C
G
G
N
E
----
A
K
F
R
L
A
V
L
---------
F
Q
M
T
Y
L
-----
G
T
P
L
I
Y
Y
G
D
E
I
--
G
M
A
G
A
T
DPDCRRPMIWEEKEQN
R
G
L
F
E
F
Y
K
E
L
I
R
L
R
H
R
--
L
A
--
S
L
T
R
G
N
V
R
S
W
H
A
D
K
Q
AN
L
Y
A
F
V
R
T
V
Q
D
-
Q
-
H
--
V
G
V
V
L
N
N
R
G
E
K
Q
T
V
L
L
QVPESG
G
K
T
W
L
D
C
L
-----
T
G
E
E
V
H
G
K
Q
G
Q
L
K
L
T
L
R
P
Y
Q
G
M
I
L
W
NGR------
49
Fugue
43.17
17%
-4
- C5 -
2O5V
1
RECF_DEIRA
A:
[2-359]
GDV
R
L
S
A
-
L
S
T
L
N
Y
R
N
-----
L
A
P
--
G
T
L
--
N
F
P
E
G
V
T
G
I
Y
G
E
N
G
A
G
K
T
N
L
L
E
A
A
Y
L
A
-------
L
T
G
Q
TDAP
R
I
E
--------
Q
L
I
Q
A
G
E
--
T
E
A
Y
V
R
A
D
L
Q
QGG
S
L
S
I
Q
--
E
V
G
L
G
R
G
R
R
Q
L
K
V
D
G
V
R
A
R
T
G
D
-
L
P
R
G
G
-
A
V
W
I
R
P
E
D
S
E
L
V
F
G
P
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
------
L
S
A
R
Y
G
E
--
Q
--
L
S
--
R
Y
E
R
T
V
S
Q
R
N
A
A
L
R
G
G
E
E
W
A
M
H
V
W
D
D
V
L
L
K
L
G
T
E
I
M
L
F
R
R
R
A
L
T
R
----
L
D
E
L
A
R
E
A
N
A
Q
L
G
S
R
K
T
L
A
L
T
---
L
T
E
S
T
S
P
E
T
Y
A
A
D
L
R
G
R
R
A
-----
E
E
L
A
R
G
S
T
V
T
G
P
H
R
D
D
L
L
L
T
L
G
D
F
P
--
A
S
D
Y
A
S
R
G
E
G
R
T
V
A
L
A
L
R
--
R
A
E
L
E
L
L
R
E
K
F
G
E
D
-
P
V
L
L
L
D
D
F
T
A
------
E
L
D
P
---
H
R
R
Q
Y
L
L
D
L
A
A
S
V
P
Q
A
I
V
T
G
T
E
L
---
A
P
G
A
A
L
T
L
R
A
Q
A
G
R
F
T
P
V
A
D
E
E
M
Q
A
E
--
G
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
40.67
22%
-30
- C4 -
3KTA
2
SMC_PYRFU
A:
[3-169]
---
Y
I
E
K
-
L
E
L
K
G
F
K
S
-----
Y
G
N
K
K
V
V
I
--
P
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
-------
L
G
G
L
----
S
A
K
AMRASRIS
D
L
I
F
A
G
S
PA
K
Y
A
E
V
A
I
Y
F
N
---
N
E
D
R
-----------------
G
F
P
I
D
-
E
D
E
V
V
I
R
R
-
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
MISPDG
Y
N
I
V
L
Q
G
--
D
IT
K
F
--
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
40.00
15%
-25
- C1 -
4QEI
1
SYG_HUMAN
A:
[1-617]
----------
I
V
D
R
A
K
-----
M
G
D
--
T
L
K
--
R
--
R
F
F
Y
D
Q
A
F
A
I
Y
G
G
----
V
S
G
L
Y
D
F
-------
G
-------
P
V
G
--------
C
A
L
K
N
N
I
--
I
Q
T
W
R
Q
H
F
I
Q
---
E
E
Q
I
L
E
I
D
C
T
M
L
T
P
E
P
V
L
K
T
S
G
H
V
D
K
F
A
D
F
M
V
-------
K
D
V
K
N
G
E
R
F
R
A
D
H
L
L
K
A
H
L
Q
K
L
Q
Q
E
L
------
A
D
L
F
V
N
F
--
N
--
L
M
F
K
T
F
I
G
P
G
G
N
M
P
G
Y
L
R
P
E
T
A
Q
G
I
F
L
N
F
K
R
L
L
E
F
------------------------
N
Q
G
K
L
P
F
A
A
A
Q
I
G
N
S
F
R
N
E
I
S
P
R
S
G
L
I
R
V
R
E
F
-
T
M
A
E
-----
I
E
H
F
V
D
P
S
E
K
D
H
P
K
F
Q
N
V
A
D
L
H
L
Y
L
--
Y
S
A
K
A
Q
V
S
G
Q
S
A
R
K
M
R
L
G
--
D
A
V
E
Q
G
V
I
N
N
------
T
V
L
G
Y
F
I
G
R
I
Y
L
Y
L
T
K
V
G
I
---
S
P
D
K
L
R
F
R
Q
H
M
E
D
C
W
D
A
E
S
K
T
S
Y
---
G
W
I
E
I
V
G
C
A
D
R
S
C
Y
D
L
-
S
C
H
A
R
A
T
K
V
--
P
L
V
A
E
K
P
L
K
E
P
K
T
V
N
V
----
V
Q
F
E
P
S
K
G
A
I
G
K
A
Y
K
K
D
--------
A
K
L
------
V
M
E
Y
L
A
I
C
D
E
C
Y
I
T
----------------
E
M
E
M
L
L
N
E
K
G
E
F
T
I
E
--
T
Q
L
T
K
D
M
I
N
V
K
R
F
Q
K
T
L
Y
V
E
E
V
V
P
N
V
I
E
P
-
S
F
G
L
G
R
I
M
Y
T
V
F
E
H
-------
T
F
H
V
R
E
G
D
E
----
Q
R
T
F
F
S
F
P
AVVAPFK
C
S
V
L
P
L
S
Q
N
Q
E
F
M
P
F
V
K
E
L
S
E
A
L
T
R
H
G
V
S
H
------------------
K
V
D
D
S
S
G
S
I
G
R
R
Y
A
R
T
--
D
E
I
G
V
A
F
G
V
T
I
D
F
D
T
V
N
K
T
--
P
H
T
A
T
L
R
D
-
R
-
D
-
S
--
M
R
Q
I
R
A
E
I
S
E
-----
L
------
P
S
I
V
Q
D
L
A
-----
N
G
N
I
T
W
A
D
V
E
A
R
Y
P
L
F
E
G
Q
E
T
G
KK----------
27
HHSearch
39.77
21%
-62
- C4 -
4UX3
2
A:
[429-527]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
L
S
G
G
Q
K
----
T
V
C
A
I
A
L
I
---------
L
A
I
Q
M
V
---
D
P
A
S
F
Y
L
F
D
E
I
D
A
--
A
L
D
K
------------------
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
--
A
Q
--
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
--
K
F
F
R
V
K
Y
E
N
----
K
--
I
S
T
V
I
E
V
N
----
R
E
E
A
------
I
G
F
I
R
------------------------------------------
42
HHSearch
39.63
25%
-55
- C4 -
3KTA
1
?
B:
[61-152]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
-------
E
-
A
M
S
G
G
E
K
----
A
L
T
A
L
A
F
V
---------
F
A
I
Q
K
F
---
K
P
A
P
F
Y
L
F
D
E
I
D
A
--
H
L
D
D
------------------
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
--
S
Q
--
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
--
K
I
I
G
V
S
M
R
D
----
G
--
V
S
K
V
V
S
L
S
-------------------------------------------------------------
41
HHSearch
39.29
31%
-54
- C4 -
1E69
-
?
A:
[1072-1151]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
-------
S
-
L
L
S
G
G
E
K
----
A
L
V
G
L
A
L
L
---------
F
A
L
M
E
I
---
K
P
S
P
F
Y
V
L
D
E
V
D
S
--
P
L
D
D
------------------
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
--
T
Q
--
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
--
L
L
H
G
V
T
-------------------------------------------------------------------------------
12
PsiBlast_PDB
38.86
31%
-37
- C4 -
1E69
-
?
A:
[1077-1146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
E
K
----
A
L
V
G
L
A
L
L
---------
F
A
L
M
E
I
K
P
S
P
---
F
Y
V
L
D
E
V
D
S
--
P
L
D
D
------------------
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
--
T
Q
--
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
--
L
------------------------------------------------------------------------------------
52
Fugue
38.38
13%
-15
- C5 -
3PDY
2
PLEC_HUMAN
A:
[7-208]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
T
L
R
Y
-----
L
Q
D
L
L
A
W
V
E
E
N
Q
H
R
V
D
G
A
E
W
G
V
--
D
--
L
P
S
V
E
A
Q
L
G
S
H
R
G
L
H
Q
S
I
--
E
E
F
R
A
K
I
E
R
A
R
S
D
E
-
G
Q
L
S
P
A
T
R
G
A
Y
R
D
C
L
G
R
L
D
L
---
Q
Y
A
K
L
L
N
S
S
K
A
R
L
R
S
L
E
S
L
H
S
F
V
---
A
A
A
T
K
E
L
M
W
L
N
E
K
E
E
E
-
E
V
G
F
D
W
S
D
R
NT
N
M
T
A
K
K
E
S
Y
S
A
L
M
R
E
L
----
E
L
K
E
K
K
I
K
E
L
Q
N
--
A
G
D
--------
R
L
L
R
E
DHPA
R
P
T
V
E
S
F
Q
A
A
L
Q
T
Q
----------------
W
S
W
M
L
Q
L
C
C
C
I
E
A
H
L
--
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
37.86
24%
-56
- C4 -
3ZGX
-
SMC_BACSU
A:
[1084-1175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
L
-------
N
-
L
L
S
G
G
E
R
----
A
L
T
A
I
A
L
L
---------
F
S
I
L
K
V
---
R
P
V
P
F
C
V
L
D
E
V
E
A
--
A
L
D
E
------------------
A
N
V
F
R
F
A
Q
Y
L
K
K
Y
S
S
D
--
T
Q
--
F
I
V
I
T
H
R
K
G
T
M
E
E
A
D
--
V
L
Y
G
V
T
M
---------
V
S
K
V
I
S
---------------------------------------------------------------
31
HHSearch
37.56
23%
-57
- C4 -
3AUY
2
RAD50_METJA
A:
[277-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
-------
D
-
N
L
S
G
G
E
Q
----
I
A
V
A
L
S
L
R
---------
L
A
I
A
N
A
L
I
G
N
R
V
E
C
I
I
L
D
E
P
T
V
--
Y
L
D
E
------------------
N
R
R
A
K
L
A
E
I
F
R
K
V
K
S
I
--
P
Q
--
M
I
I
I
T
H
H
R
E
L
E
D
V
A
D
--
V
I
I
N
V
K
K
D
G
----------------------------------------------------------------------------
37
HHSearch
37.50
20%
-29
- C4 -
2O5V
1
RECF_DEIRA
A:
[5-140]
---
R
L
S
A
-
L
S
T
L
N
Y
R
N
-----
L
A
P
--
G
T
L
--
N
F
P
E
G
V
T
G
I
Y
G
E
N
G
A
G
K
T
N
L
L
E
A
A
Y
L
A
-------
L
T
G
Q
----
T
D
A
PRIE----
Q
L
I
Q
A
G
E
--
T
E
A
Y
V
R
A
D
L
Q
---
Q
G
-------------------------
G
S
L
S
I
Q
E
V
-
G
L
G
-
R
G
R
R
Q
L
K
V
D
G
V
R
A
R
T
G
D
L
P
R
G
G
--
A
------
V
W
I
R
P
E
D
--
S
--
E
L
--
V
F
G
P
P
S
G
R
R
A
Y
L
D
S
L
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------