@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1747: (2016-05-04 )
MPMSQPAAPPVLTVRYEGSERTFAAGHDVVVGRDLRADVRVAHPLISRAHLLLRFDQGRWVAIDNGSLNGLYLNNRRVPVVDIYDAQRVHIGNPDGPALDFEVGRHRGSAGRPPQTTSIRLPNLSAGAWPTDGPPQTGTLGSGQLQQLPPATTRIPAAPPSGPQPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGTEAGNLATSMMKILRPGRLTGELPPGAVRIGRANDNDIVIPEVLASRHHATLVPTPGGTEIRDNRSINGTFVNGARVDAALLHDGDVVTIGNIDLVFADGTLARREENLLETRVGGLDVRGVTWTIDGDKTLLDGISLTARPGMLTAVIGPSGAGKSTLARLVAGYTHPTDGTVTFEGHNVHAEYASLRSRIGMVPQDDVVHGQLTVKHALMYAAELRLPPDTTKDDRTQVVARVLEELEMSKHIDTRVDKLSGGQRKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLLAPGGKTAFCGPPTQIGPVMGTTNWADIFSTVADDPDAAKARYLARTGPTPPPPPVEQPAELGDPAHTSLFRQFSTIARRQLRLIVSDRGYFVFLALLPFIMGALSMSVPGDVGFGFPNPMGDAPNEPGQILVLLNVGAVFMGTALTIRDLIGERAIFRREQAVGLSTTAYLIAKVCVYTVLAVVQSAIVTVIVLVGKGGPTQGAVALSKPDLELFVDVAVTCVASAMLGLALSAIAKSNEQIMPLLVVAVMSQLVFSGGMIPVTGRVPLDQMSWVTPARWGFAASAATVDLIKLVPGPLTPKDSHWHHTASAWWFDMAMLVALSVIYVGFVRWKIRLKAC
Atome Classification :
(48 SA)
------.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260...--....270.......280.......290.......300.......310...---------....320......-.---330----........340.......350.......360.......--370---.......380-.-..----.-.-----..-.--.390-...-..--....400.----......-.410.......420.......430.-....--..440---..-------.-------.---------.----..----450--.----.---.----.--.....460.......470.......480.......490..-.....500.-......-.510---.....-.-..520.......530..--.....540.......550.......560.......570.......580.......590....-...600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MPMSQPAAP
P
V
L
T
V
R
YEGSE
R
T
FAAGH
D
V
V
VGRDLR
A
D
V
R
V
A
H
P
L
I
S
R
A
H
L
L
L
R
FDQG
R
W
V
A
IDNGSL
N
G
L
Y
LNNRR
V
P
V
V
D
I
YD
A
Q
R
V
H
IGNPDGPALDFEVGRHRGSAGRPPQT
T
S
I
RLPNLSAGAWPTDGPPQTGTLGS-G
Q
L
QQLPPATTRIPAAPPSGPQPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGT
E
A
G
N
L
A
T
S
M
M
K
I
LRPGRLTGELPPG
A
V
R
IGRANDN
D
I
V
I
P
E
V
L
ASRH
H
A
T
L
V
PTPGGTEIRD--NRSIN
G
T
F
VNG
A
R
V
D
A
A
L
LHDG
D
V
V
T
IG
N
I
D
L
V
FADG
T
L
A
R
R
E
E
N
L
L
E
T
R---------VG
G
L
D
VR
G
V
T
W
T
I-D---G-D----
K
T
L
LDGISLTARP
G
M
L
T
A
V
IGPSGA
G
K
S
T
L
A
R
L
V
A
GYT--HPT---D
G
T
V
T
F
EG---
H
-
N
V
----
H
-
A
-----
E
Y
-
A
--
S
L
---
R
S
R-IG--MVPQDD-V----VH
G
Q
L
T
-
V
K
H
A
L
M
Y
A
A
ELRLPPDTTK
D
D
R
T
Q
V
-
V
A
R
V
--
L
E
E
L
E
---
M
S
-------
K
-------
H
---------
I
----
D
T
----
R
----
V
----
D
---K----L--SGGQR
K
R
A
S
V
A
L
E
LLTG
P
S
L
L
I
L
DEPTSGLD
P
A
L
D
R
Q
V
M
T
-
M
L
R
Q
L
AD-A-G
R
V
V
L
V
-
V
TH----S
L
T
Y
L
-
D
-
V
C
D
Q
V
L
L
LAPGGKTAFC--GPPTQIGPVMGTT
N
W
A
D
I
F
S
T
VADDP
D
A
A
K
A
R
Y
LARTGPTPPPPPVEQPAELG
D
P
A
H
T
S
L
F
R
-
Q
F
S
T
I
A
R
R
Q
L
R
L
I
VSDR
G
Y
F
V
F
L
A
L
L
P
F
I
M
G
A
L
SMSVPGDVGFGFPNPMGDAPNEP
G
Q
I
L
V
L
L
NV
G
A
V
F
MG
T
A
L
T
I
R
D
L
IG
E
R
A
I
F
R
R
E
QAVG
L
S
T
T
A
Y
L
I
A
K
V
C
V
Y
T
V
L
A
V
V
Q
S
A
I
V
T
V
I
V
L
V
GKGGPTQ
G
A
V
ALSKP
D
L
E
L
F
V
D
V
A
V
T
C
V
A
S
A
M
L
G
L
A
L
S
A
I
AKSNEQ
I
M
P
L
L
V
V
A
V
M
S
Q
L
V
FSG
G
M
I
PVTGRVPLDQMSWVTPARWGFAASA
A
T
V
D
L
I
K
LVPGPLTPKDSHWHHT
A
S
A
W
W
F
D
M
A
M
L
V
A
L
S
V
I
Y
V
G
F
V
R
W
K
I
R
L
KAC
110
HHSearch
71.30
28%
-106
- C4 -
4HUQ
-
ECFA2_LACBA
A:
[2-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
A
F
E
H
V
T
Y
T
Y
-
Q
---
A
-
G
TPMA
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
--
K
P
T
---
S
G
T
I
K
I
D
E
---
F
-
T
I
----
T
-
P
ETTNA
A
L
-
K
--
P
L
---
R
Q
H
-
V
G
--
M
V
F
Q
F
P
-
E
N---
Q
L
F
E
E
T
-
V
R
Q
D
I
A
F
G
P
K
N
F
G
---
M
A
D
A
D
A
L
A
L
-
A
D
E
M
--
L
T
T
V
G
---
L
D
-------
Q
S------
Y
---------
A
----
E
R
----
S
----
P
----
F
---
E
----
L
--
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
H
Q
E
Q
-
G
L
T
I
V
L
-
V
T
H
----
Q
M
E
D
V
A
Q
-
Y
A
E
Q
V
A
V
M
H
-
E
G
R
L
M
K
F
--
G
T
P
A
D
V
F
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
70.34
29%
-102
- C4 -
3TUI
1
METN_ECOLI
C:
[23-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
---
Q
-
G
TRT-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
--
R
P
T
---
E
G
S
V
L
V
D
G
---
Q
-
E
L
----
T
-
T
LSES-
E
L
-
T
--
K
A
---
R
R
Q
-
I
G
--
M
I
F
Q
H
F
-
N
----
L
L
S
S
R
T
-
V
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
-
V
T
E
L
--
L
S
L
V
G
---
L
G
-------
D
-------
K
---------
H
----
D
S
----
Y
----
P
----
S
---
N
----
L
--
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
-
L
L
K
D
I
N
R
R
L
-
G
L
T
I
L
L
-
I
T
H
----
E
M
D
V
V
K
R
-
I
C
D
C
V
A
V
I
S
-
N
G
E
L
I
E
Q
--
D
T
V
S
E
V
F
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Fugue
70.11
18%
-31
- C4 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
-
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
---
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
SL
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
RVIDRA
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
---
G
R
E
----
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
--
D
I
D
---
E
G
H
I
L
M
D
G
---
H
-
D
L
----
R
E
Y
-----
T
L
-
A
--
S
L
---
R
N
Q
-
V
A
--
L
V
S
Q
N
V
-
H
----
L
F
N
D
-
T
-
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
--
I
N
K
M
D
NG-
L
D
-------
T
-------
I
---------
I
----
G
E
----
N
----
G
----
V
---
L
----
L
--
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
-
A
L
D
E
L
Q
K
---
N
R
T
S
L
V
-
I
A
H
----
R
L
S
T
I
-
E
-
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
--
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
70.04
29%
-110
- C4 -
3RLF
3
MALK_ECOLI
A:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
--
T
I
T
---
S
G
D
L
F
I
G
E
---
K
-
R
M
----
N
-
D
-----
T
--
P
--
P
A
---
E
R
G
-
V
G
--
M
V
F
Q
S
Y
-
A
----
L
Y
P
H
L
S
-
V
A
E
N
M
S
F
G
L
K
L
A
G
---
A
K
K
E
V
I
N
Q
R
-
V
N
Q
V
--
A
E
V
L
Q
---
L
A
-------
H
-------
L
---------
L
----
D
R
----
K
----
P
----
K
---
A
----
L
--
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
-
E
I
S
R
L
H
K
R
L
-
G
R
T
M
I
Y
-
V
T
H
----
D
Q
V
E
A
M
T
-
L
A
D
K
I
V
V
L
D
-
A
G
R
V
A
Q
V
--
G
K
P
L
E
L
Y
H
Y
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
69.18
30%
-107
- C4 -
4MRS
1
ATM1_NOVAD
A:
[357-585]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---------
R
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
---
R
-
D
----
R
E
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
--
D
P
W
---
E
G
R
I
L
I
D
G
---
Q
-
D
I
----
A
-
H
V----
T
Q
-
T
--
S
L
---
R
A
A
-
L
G
--
I
V
P
Q
D
S
-
V
----
L
F
N
D
-
T
-
I
G
Y
N
I
A
Y
G
R
D
G
A
---------
S
R
A
E
-
V
D
A
A
--
A
K
G
A
A
---
I
A
-------
D
F
I
A
R
LPQ
G
---------
Y
----
D
T
EVGE
R
----
G
----
L
---
K
----
L
--
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
-
T
M
R
A
V
A
--
S
-
H
R
T
T
I
S
-
I
A
H
----
R
L
S
T
I
-
A
-
D
S
D
T
I
L
V
L
D
-
Q
G
R
L
A
E
Q
--
G
S
H
L
D
L
L
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Fugue
68.69
24%
-98
- C4 -
3TUZ
3
METN_ECOLI
H:
[23-362]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
QGT
R
-
T
----
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
--
R
P
T
---
E
G
S
V
L
V
D
G
---
Q
-
E
L
TTLS
E
-
S
-----
E
L
-
T
--
K
A
---
R
R
Q
-
I
G
--
M
I
F
Q
H
F
-
N
----
L
L
S
S
R
T
-
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
-
V
T
E
L
--
L
S
L
V
G
---
L
G
-------
D
-------
K
---------
H
----
D
S
----
Y
----
P
----
S
---
N
----
L
--
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
-
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
-
I
T
H
----
E
M
D
V
V
K
R
-
I
C
D
C
V
A
V
I
S
N
G
---------------
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
----
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
68.20
29%
-106
- C4 -
1Z47
1
?
A:
[11-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------
S
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
---
G
-
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
--
R
P
T
---
K
G
D
V
W
I
G
G
---
K
-
R
V
----
T
-
D
------
L
-
P
--
P
Q
---
K
R
N
-
V
G
--
L
V
F
Q
N
Y
-
A
----
L
F
Q
H
M
T
-
V
Y
D
N
V
S
F
G
L
R
E
K
R
V
---
P
K
D
E
M
D
A
R
-
V
R
E
L
--
L
R
F
M
R
---
L
E
-------
S
-------
Y
---------
A
----
N
R
----
F
----
P
----
H
---
E
----
L
--
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
-
F
V
R
Q
V
H
D
E
M
-
G
V
T
S
V
F
-
V
T
H
----
D
Q
E
E
A
L
E
-
V
A
D
R
V
L
V
L
H
-
E
G
N
V
E
Q
F
--
G
T
P
E
E
V
Y
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
68.13
27%
-106
- C4 -
1OXX
21
?
K:
[3-231]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
K
N
V
S
K
V
F
-
K
---
K
G
K
----
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
--
V
P
S
---
T
G
E
L
Y
F
D
D
---
R
-
L
V
----
A
-
S
NGKL-
I
V
-
P
--
P
E
---
D
R
K
-
I
G
--
M
V
F
Q
T
W
-
A
----
L
Y
P
N
L
T
-
A
F
E
N
I
A
F
P
L
T
N
M
K
---
M
S
K
E
E
I
R
K
R
-
V
E
E
V
--
A
K
I
L
D
---
I
H
-------
H
-------
V
---------
L
----
N
H
----
F
----
P
----
R
---
E
----
L
--
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
-
L
V
K
E
V
Q
S
R
L
-
G
V
T
L
L
V
-
V
S
H
----
D
P
A
D
I
F
A
-
I
A
D
R
V
G
V
L
V
-
K
G
K
L
V
Q
V
--
G
K
P
E
D
L
Y
D
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
67.45
29%
-104
- C4 -
2IT1
-
?
A:
[3-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
K
L
E
N
I
V
K
K
F
-
G
---
N
------
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
--
K
P
T
---
S
G
K
I
Y
F
D
E
---
K
-
D
V
----
T
-
E
-----
L
--
P
--
P
K
---
D
R
N
-
V
G
--
L
V
F
Q
N
W
-
A
----
L
Y
P
H
M
T
-
V
Y
K
N
I
A
F
P
L
E
L
R
K
A
---
P
R
E
E
I
D
K
K
-
V
R
E
V
--
A
K
M
L
H
---
I
D
-------
K
-------
L
---------
L
----
N
R
----
Y
----
P
----
W
---
Q
----
L
--
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
-
E
L
K
R
L
Q
K
E
L
-
G
I
T
T
V
Y
-
V
T
H
----
D
Q
A
E
A
L
A
-
M
A
D
R
I
A
V
I
R
-
E
G
E
I
L
Q
V
--
G
T
P
D
E
V
Y
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
67.16
26%
-111
- C4 -
2YYZ
3
?
A:
[3-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
R
V
V
N
L
K
K
Y
F
-
G
---
K
------
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
--
K
P
T
---
S
G
E
I
Y
F
D
D
---
V
-
L
V
----
N
-
D
-----
I
--
P
--
P
K
---
Y
R
E
-
V
G
--
M
V
F
Q
N
Y
-
A
----
L
Y
P
H
M
T
-
V
F
E
N
I
A
F
P
L
R
A
R
R
---
I
S
K
D
E
V
E
K
R
-
V
V
E
I
--
A
R
K
L
L
---
I
D
-------
N
-------
L
---------
L
----
D
R
----
K
----
P
----
T
---
Q
----
L
--
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
-
E
I
K
H
L
Q
Q
E
L
-
G
I
T
S
V
Y
-
V
T
H
----
D
Q
A
E
A
M
T
-
M
A
S
R
I
A
V
F
N
-
Q
G
K
L
V
Q
Y
--
G
T
P
D
E
V
Y
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
66.06
29%
-90
- C4 -
4HUQ
-
ECFA1_LACBA
B:
[3-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
I
I
S
V
D
H
L
T
Y
Q
Y
-
D
---
E
N
Q
----
A
P
A
L
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
--
P
F
T
---
Q
G
S
V
T
V
G
G
---
I
-
T
L
----
T
-
P
E----
T
V
-
W
--
Q
V
---
R
E
Q
-
I
G
--
M
I
F
Q
N
P
D
N
----
Q
F
V
G
A
T
-
V
E
D
D
V
A
F
G
L
E
N
R
Q
---
I
S
R
D
E
M
V
P
R
-
V
Q
A
A
--
L
A
Q
V
G
---
M
T
-------
S
-------
F
---------
A
----
Q
R
----
E
----
P
----
S
---
S
----
L
--
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
R
I
E
M
L
A
-
I
V
R
Q
L
R
Q
Q
Q
-
N
L
T
V
I
S
-
I
T
H
----
D
I
D
E
A
-
A
-
S
A
D
R
V
L
V
I
D
-
D
G
R
L
V
D
E
--
A
V
P
S
Q
I
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
66.00
27%
-101
- C4 -
3FVQ
3
FBPC_NEIG1
A:
[3-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
H
I
G
H
L
S
K
S
F
-
Q
---
N
------
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
--
Q
P
D
---
S
G
E
I
S
L
S
G
---
K
-
T
I
----
F
-
S
KN
T
--
N
L
-
P
--
V
R
---
E
R
R
-
L
G
--
Y
L
V
Q
E
G
-
V
----
L
F
P
H
L
T
-
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
---
R
T
A
Q
E
R
Q
R
-
I
E
A
M
--
L
E
L
T
G
---
I
S
-------
E
-------
L
---------
A
----
G
R
----
Y
----
P
----
H
---
E
----
L
--
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
-
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
-
V
S
H
----
D
R
E
E
A
L
Q
-
Y
A
D
R
I
A
V
M
K
-
Q
G
R
I
L
Q
T
--
A
S
P
H
E
L
Y
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.76
31%
-103
- C4 -
1VPL
2
?
A:
[26-222]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
----
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
--
K
P
S
---
S
G
I
V
T
V
F
G
---
K
-
N
V
----
V
-
E
-----
E
P
-
H
--
E
V
---
R
K
L
-
I
S
--
Y
L
P
E
E
A
-
G
----
A
Y
R
N
M
Q
-
G
I
E
Y
L
R
F
V
A
G
F
Y
A
---
S
S
S
S
E
I
E
E
M
-
V
E
R
A
--
T
E
I
A
G
---
L
G
-------
E
-------
K
---------
I
----
K
D
----
R
----
V
----
S
---
T
----
Y
--
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
-
I
L
K
Q
A
S
Q
-
E
-
G
L
T
I
L
V
-
S
S
H
----
N
M
L
E
V
-
E
F
L
C
D
R
I
A
L
I
H
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
65.54
27%
-108
- C4 -
1V43
-
?
A:
[9-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------
M
V
E
V
K
L
E
N
L
T
K
R
F
-
G
---
N
------
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
--
E
P
T
---
E
G
R
I
Y
F
G
D
---
R
-
D
V
----
T
-
Y
-----
L
--
P
--
P
K
---
D
R
N
-
I
S
--
M
V
F
Q
-----------
H
M
T
-
V
Y
E
N
I
A
F
P
L
--
K
K
---
F
P
K
D
E
I
D
K
R
-
V
R
W
A
--
A
E
L
L
Q
---
I
E
-------
E
-------
L
---------
L
----
N
R
----
Y
----
P
----
A
---
Q
----
L
--
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
Q
Q
K
L
-
K
V
T
T
I
Y
-
V
T
H
----
D
Q
V
E
A
M
T
-
M
G
D
R
I
A
V
M
N
-
R
G
Q
L
L
Q
I
--
G
S
P
T
E
V
Y
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
65.49
27%
-111
- C4 -
3D31
-
?
A:
[2-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
I
E
S
L
S
R
K
W
-
K
---
N
-------
F
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
--
V
P
D
---
S
G
R
I
L
L
D
G
---
K
-
D
V
----
T
-
D
-----
L
--
S
--
P
E
---
K
H
D
-
I
A
--
F
V
Y
Q
N
Y
-
S
----
L
F
P
H
M
N
-
V
K
K
N
L
E
F
G
M
R
M
K
K
------
I
K
D
P
K
R
-
V
L
D
T
--
A
R
D
L
K
---
I
E
-------
H
-------
L
---------
L
----
D
R
----
N
----
P
----
L
---
T
----
L
--
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
-
M
L
S
V
L
H
K
K
N
-
K
L
T
V
L
H
-
I
T
H
----
D
Q
T
E
A
R
I
-
M
A
D
R
I
A
V
V
M
-
D
G
K
L
I
Q
V
--
G
K
P
E
E
I
F
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
65.32
28%
-104
- C4 -
4Q9H
-
MDR1A_MOUSE
A:
[1028-1259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
N
V
Q
F
S
G
V
V
F
N
Y
-
P
---
T
-
R
PS--
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
--
D
P
M
---
A
G
S
V
F
L
D
G
---
K
-
E
I
----
K
-
Q
L----
N
V
-
Q
--
W
L
---
R
A
Q
-
L
G
--
I
V
S
Q
E
P
-
I
----
L
F
D
C
-
S
-
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
-------
S
Y
E
E
-
I
V
R
A
--
A
K
E
A
N
---
I
H
Q
F
I
D
S
LP
D
-------
K
---------
Y
----
N
T
----
R
VGDK
G
----
T
---
Q
----
L
--
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
-
A
L
D
K
A
R
--
E
-
G
R
T
C
I
V
-
I
A
H
----
R
L
S
T
I
-
Q
-
N
A
D
L
I
V
V
I
Q
-
N
G
K
V
K
E
H
--
G
T
H
Q
Q
L
L
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
64.97
30%
-95
- C4 -
3WMG
1
?
A:
[348-582]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
---
T
-
R
MN--
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
--
D
I
E
PQG
G
G
L
L
L
F
D
G
---
T
-
P
A
----
W
-
N
Y----
D
F
-
H
--
A
L
---
R
S
Q
-
I
G
--
L
V
S
Q
E
P
-
V
----
L
F
S
G
-
T
-
I
R
D
N
I
L
Y
G
K
R
D
A
---------
T
D
E
E
-
V
I
Q
A
--
L
R
E
A
N
---
A
Y
S
F
V
M
A
LP
D
-------
G
---------
L
----
D
T
----
E
V
G
ER
G
----
L
---
A
----
L
--
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
-
A
L
D
R
M
M
A
S
D
-
G
V
T
S
V
V
-
I
A
H
----
R
L
S
T
V
-
A
-
R
A
D
L
I
L
V
M
Q
-
D
G
V
V
V
E
Q
--
G
N
H
S
E
L
M
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
64.97
26%
-104
- C4 -
4MYC
-
ATM1_YEAST
A:
[433-661]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
I
T
F
E
N
V
T
F
G
Y
-
H
---
P
-
D
----
R
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
--
D
P
E
---
S
G
R
I
L
I
N
G
---
R
-
D
I
----
K
-
E
Y----
D
I
-
D
--
A
L
---
R
K
V
-
I
G
--
V
V
P
Q
D
T
-
P
----
L
F
N
D
-
T
-
I
W
E
N
V
K
F
G
R
I
D
A
---------
T
D
E
E
-
V
I
T
V
--
V
E
K
A
Q
---
L
A
-------
P
L
I
K
K
LPQ
G
---------
F
----
D
T
----
I
----
V
G
ER
G
L
---
M
----
I
--
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
-
T
I
R
D
N
F
T
S
G
-
S
R
T
S
V
Y
-
I
A
H
----
R
L
R
T
I
-
A
-
D
A
D
K
I
I
V
L
D
-
N
G
R
V
R
E
E
--
G
K
H
L
E
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.55
32%
-82
- C4 -
3NH6
2
A:
[47-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
---------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
---
G
-
R
----
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
--
D
I
S
---
S
G
C
I
R
I
D
G
---
Q
-
D
I
S---
Q
-
V
-----
T
Q
-
A
--
S
L
---
R
S
H
-
I
G
--
V
V
P
Q
D
T
-
V
----
L
F
N
D
--------
T
I
A
D
N
I
R
Y
G
R
V
T
A
G
N
D
E
V
E
A
-
A
A
Q
A
A
G
I
H
D
A
I
---
M
A
FPEGYR-
T
-------
Q
---------
V
----
G
E
----
R
----
G
----
L
---
K
----
L
--
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
--
A
-
N
R
T
T
I
V
-
V
A
H
----
R
L
S
T
V
-
V
-
N
A
D
Q
I
L
V
I
K
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.31
32%
-80
- C4 -
3NHA
4
A:
[47-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
---------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
-----
R
----
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
--
D
I
S
---
S
G
C
I
R
I
D
G
---
Q
-
D
I
S---
Q
-
V
-----
T
Q
-
A
--
S
L
---
R
S
H
-
I
G
--
V
V
P
Q
D
T
-
V
----
L
F
N
D
--------
T
I
A
D
N
I
R
Y
G
R
V
T
A
G
N
D
E
V
E
A
-
A
A
Q
A
A
G
I
H
D
A
I
---
M
A
FPEGYR-
T
-------
Q
---------
V
----
G
E
----
R
----
G
----
L
---
K
----
L
--
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
--
A
-
N
R
T
T
I
V
-
V
A
H
----
R
L
S
T
V
-
V
-
N
A
D
Q
I
L
V
I
K
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
64.03
33%
-87
- C4 -
4U00
3
?
A:
[19-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
--
D
F
Q
---
E
G
E
V
V
V
D
G
---
L
-
S
V
----
K
-
D
-----
D
R
-
A
L
R
E
I
---
R
R
E
-
V
G
--
M
V
F
Q
Q
F
-
N
----
L
F
P
H
M
T
-
V
L
E
N
V
T
L
A
-----
P
M
R
V
R
R
W
P
R
E
K
A
-
E
K
K
A
--
L
E
L
L
E
---
R
V
-------
G
-------
I
---------
L
----
D
Q
----
A
----
R
----
K
YPA
Q
----
L
--
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
Q
-
G
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
--
G
R
P
E
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.03
32%
-80
- C4 -
3NH9
3
A:
[47-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
---------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
---
G
-
R
----
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
--
D
I
S
---
S
G
C
I
R
I
D
G
---
Q
-
D
I
S---
Q
-
V
-----
T
Q
-
A
--
S
L
---
R
S
H
-
I
G
--
V
V
P
Q
D
T
-
V
----
L
F
N
D
--------
T
I
A
D
N
I
R
Y
G
R
V
T
A
G
N
D
E
V
E
A
-
A
A
Q
A
A
G
I
H
D
A
I
---
M
A
FPEGYR-
T
-------
Q
---------
V
----
G
E
----
R
----
G
----
L
---
K
----
L
--
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
--
A
-
N
R
T
T
I
V
-
V
A
H
----
R
L
S
T
V
-
V
-
N
A
D
Q
I
L
V
I
K
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.90
33%
-99
- C4 -
2OLK
2
?
B:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.74
32%
-79
- C4 -
3NHB
3
A:
[47-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
F
Q
---------
K
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
-----
R
----
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
--
D
I
S
---
S
G
C
I
R
I
D
G
---
Q
-
D
I
S---
Q
-
V
-----
T
Q
-
A
--
S
L
---
R
S
H
-
I
G
--
V
V
P
Q
D
T
-
V
----
L
F
N
D
--------
T
I
A
D
N
I
R
Y
G
R
V
T
A
G
N
D
E
V
E
A
-
A
A
Q
A
A
G
I
H
D
A
I
---
M
A
FPEGYR-
T
-------
Q
---------
V
----
G
E
----
R
----
G
----
L
---
K
----
L
--
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
--
A
-
N
R
T
T
I
V
-
V
A
H
----
R
L
S
T
V
-
V
-
N
A
D
Q
I
L
V
I
K
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.38
33%
-99
- C4 -
2OLK
1
?
D:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.37
33%
-97
- C4 -
2OLK
1
?
C:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.03
33%
-97
- C4 -
2Q0H
4
?
B:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
N
K
V
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
K
V
G
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.86
33%
-97
- C4 -
3C41
3
?
K:
[14-214]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.74
33%
-96
- C4 -
2OLK
1
?
A:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
N
K
V
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
K
V
G
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.65
33%
-94
- C4 -
3C4J
4
?
B:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.40
33%
-88
- C4 -
3C4J
3
?
A:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
N
K
V
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
K
V
G
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.23
33%
-95
- C4 -
3C41
3
?
J:
[14-214]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
62.11
33%
-97
- C4 -
2OLJ
3
?
B:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
NKV
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
KVG
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.10
33%
-93
- C4 -
2Q0H
4
?
A:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
N
K
V
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
K
V
G
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.07
33%
-97
- C4 -
2OLJ
4
?
A:
[35-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
--
D
F
D
---
E
G
E
I
I
I
D
G
---
I
-
N
L
----
K
-
A
-----
K
D
-
T
--
N
L
N
K
V
R
E
E
-
V
G
--
M
V
F
Q
R
F
-
N
----
L
F
P
H
M
T
-
V
L
N
N
I
T
L
A
-----
P
M
K
V
R
K
W
P
R
E
K
A
-
E
A
K
A
--
M
E
L
L
D
K
V
G
L
K
-------
D
-------
K
---------
A
----
H
A
----
Y
----
P
----
D
---
S
----
L
--
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.70
30%
-95
- C4 -
4YMU
2
?
J:
[12-212]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
--
E
P
T
---
K
G
E
V
F
I
D
G
VKI
N
-
N
G
----
K
-
V
-----
N
I
-
N
--
K
V
---
R
Q
K
-
V
G
--
M
V
F
Q
H
F
-
N
----
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
-
A
V
D
L
--
L
A
K
V
G
---
L
L
-------
D
-------
K
---------
K
----
D
Q
----
Y
----
P
----
I
---
K
----
L
--
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.68
33%
-90
- C4 -
3FVQ
3
FBPC_NEIG1
B:
[19-207]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
--
Q
P
D
---
S
G
E
I
S
L
S
G
---
K
-
T
I
----
F
-
S
-----
K
N
-
T
--
N
L
PVR
E
R
R
-
L
G
--
Y
L
V
Q
E
G
-
V
----
L
F
P
H
L
T
-
V
Y
R
N
I
A
Y
G
--
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
-
E
A
-
M
--
L
E
L
T
G
---
I
S
-------
E
-------
L
---------
A
----
G
R
----
Y
----
P
----
H
---
E
----
L
--
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
V
F
-
V
S
H
DREE
A
L
Q
Y
A
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.47
30%
-95
- C4 -
4YMV
1
?
J:
[12-212]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
--
E
P
T
---
K
G
E
V
F
I
D
G
VKI
N
-
N
G
----
K
-
V
-----
N
I
-
N
--
K
V
---
R
Q
K
-
V
G
--
M
V
F
Q
H
F
-
N
----
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
-
A
V
D
L
--
L
A
K
V
G
---
L
L
-------
D
-------
K
---------
K
----
D
Q
----
Y
----
P
----
I
---
K
----
L
--
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
-
V
T
H
----
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
60.25
32%
-89
- C4 -
4AYW
1
ABCBA_HUMAN
A:
[390-593]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
---
H
-
D
I
R---
Q
-
L
-----
N
P
-
V
--
W
L
---
R
S
K
-
I
G
--
T
V
S
Q
E
P
-
I
----
L
F
-
S
C
S
-
I
A
E
N
I
A
Y
G
A
D
---
D
P
S
S
V
T
A
E
E
I
Q
R
-
V
A
E
V
--
A
N
A
V
A
---
F
I
-------
R
-------
N
---------
F
PQGF
N
T
----
V
----
V
----
G
---
E
KG
V
L
L
--
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
D
R
L
M
D
---
G
R
T
V
L
V
-
I
A
H
----
H
L
S
T
I
-
K
-
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
60.20
32%
-82
- C4 -
4AYX
2
ABCBA_HUMAN
A:
[359-562]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
---
H
-
D
I
----
R
-
Q
-----
L
N
P
V
--
W
L
---
R
S
K
-
I
G
--
T
V
S
Q
E
P
-
I
----
L
F
-
S
C
S
-
I
A
E
N
I
A
Y
G
A
D
---
D
P
S
S
V
T
A
E
E
I
Q
R
-
V
A
E
V
--
A
N
A
V
A
---
F
I
-------
R
-------
N
FPQG-----
F
----
N
T
----
V
----
V
----
G
---
E
K
G
V
L
L
--
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
D
R
L
M
D
---
G
R
T
V
L
V
-
I
A
H
----
R
L
S
T
I
-
K
-
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.97
33%
-94
- C4 -
3FVQ
3
FBPC_NEIG1
A:
[19-212]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
--
Q
P
D
---
S
G
E
I
S
L
S
G
---
K
-
T
I
----
F
-
S
-----
K
N
-
T
--
N
L
P
VR
E
R
R
-
L
G
--
Y
L
V
Q
E
G
-
V
----
L
F
P
H
L
T
-
V
Y
R
N
I
A
Y
G
--
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
-
E
A
-
M
--
L
E
L
T
G
---
I
S
-------
E
-------
L
---------
A
----
G
R
----
Y
----
P
----
H
---
E
----
L
--
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
V
F
-
V
S
H
D
R
E
E
A
L
Q
Y
A
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
59.75
32%
-78
- C4 -
4AYT
2
ABCBA_HUMAN
A:
[359-562]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
---
H
-
D
I
----
R
-
Q
-----
L
N
P
V
--
W
L
---
R
S
K
-
I
G
--
T
V
S
Q
E
P
-
I
----
L
F
-
S
C
S
-
I
A
E
N
I
A
Y
G
A
D
---
D
P
S
S
V
T
A
E
E
I
Q
R
-
V
A
E
V
--
A
N
A
V
A
---
F
I
-------
R
-------
N
FPQG-----
F
----
N
T
----
V
----
V
----
G
---
E
KG
V
L
L
--
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
D
R
L
M
D
---
G
R
T
V
L
V
-
I
A
H
----
R
L
S
T
I
-
K
-
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.43
31%
-84
- C4 -
2IXF
4
TAP1_RAT
C:
[34-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
--
Q
P
T
---
G
G
K
V
L
L
D
G
---
E
P
L
V
----
Q
-
Y
-----
D
H
-
H
--
Y
L
---
H
T
Q
-
V
A
--
A
V
G
Q
E
P
-
L
----
L
F
G
R
-
S
-
F
R
E
N
I
A
Y
G
----
L
T
R
T
P
T
M
E
E
I
T
A
V
-
A
--------
M
E
---
S
G
-------
A
-------
H
D
F
I
SGFPQG
Y
----
D
T
----
E
----
V
GETG
N
---
Q
----
L
--
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
P
E
W
A
-
S
R
T
V
L
L
-
I
T
H
----
Q
L
S
L
A
-
E
-
R
A
H
H
I
L
F
L
K
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
56.99
31%
-89
- C4 -
2IXF
5
TAP1_RAT
A:
[34-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
--
Q
P
T
---
G
G
K
V
L
L
D
G
---
E
P
L
V
----
Q
-
Y
-----
D
H
-
H
--
Y
L
---
H
T
Q
-
V
A
--
A
V
G
Q
E
P
-
L
----
L
F
G
R
-
S
-
F
R
E
N
I
A
Y
G
----
L
T
R
T
P
T
M
E
E
I
T
A
V
-
A
--------
M
E
---
S
G
-------
A
-------
H
D
F
I
S
G
FPQG
Y
----
D
T
----
E
----
V
GETG
N
---
Q
----
L
--
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
P
E
W
A
-
S
R
T
V
L
L
-
I
T
H
----
Q
L
S
L
A
-
E
-
R
A
H
H
I
L
F
L
K
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
56.35
31%
-90
- C4 -
2IXF
4
TAP1_RAT
B:
[34-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
--
Q
P
T
---
G
G
K
V
L
L
D
G
---
E
P
L
V
----
Q
-
Y
-----
D
H
-
H
--
Y
L
---
H
T
Q
-
V
A
--
A
V
G
Q
E
P
-
L
----
L
F
G
R
-
S
-
F
R
E
N
I
A
Y
G
----
L
T
R
T
P
T
M
E
E
I
T
A
V
-
A
--------
M
E
---
S
G
-------
A
-------
H
D
F
I
S
G
FPQG
Y
----
D
T
----
E
----
V
G
ETG
N
---
Q
----
L
--
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
P
E
W
A
-
S
R
T
V
L
L
-
I
T
H
----
Q
L
S
L
A
-
E
-
R
A
H
H
I
L
F
L
K
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
56.30
31%
-87
- C4 -
2IXF
4
D:
[34-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
--
Q
P
T
---
G
G
K
V
L
L
D
G
---
E
P
L
V
----
Q
-
Y
-----
D
H
-
H
--
Y
L
---
H
T
Q
-
V
A
--
A
V
G
Q
---
L
----
L
F
G
R
-
S
-
F
R
E
N
I
A
Y
G
----
L
T
R
T
P
T
M
E
E
I
T
A
V
-
A
--------
M
E
---
S
G
-------
A
-------
H
DFISGFPQG
Y
----
D
T
----
E
----
V
GETG
N
---
Q
----
L
--
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
P
E
W
A
-
S
R
T
V
L
L
-
I
T
H
----
Q
L
S
L
A
-
E
-
R
A
H
H
I
L
F
L
K
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
54.17
32%
-54
- C4 -
2ZU0
1
SUFC_ECOLI
C:
[32-228]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
A
I
L
R
G
L
S
L
D
V
H
P
G
E
V
H
A
I
M
G
P
N
G
S
G
K
S
T
L
S
A
T
L
A
G
R
E
DY
E
V
T
---
G
G
T
V
E
F
K
G
---
K
-
D
L
----
L
-
A
-----
L
S
-
P
--
E
D
---
R
A
G
-
E
G
I
F
M
A
F
Q
Y
P
-
V
E
I
P
G
V
S
N
Q
F
F
-
L
Q
T
A
L
N
A
V
R
S
Y
R
G
Q
E
T
L
D
R
F
D
F
Q
D
L
-
M
E
E
K
--
I
A
L
L
K
---
M
P
-------
E
-------
D
---------
L
----
L
T
----
R
----
S
----
V
---
N
----
V
GF
S
G
G
E
K
K
R
N
D
I
L
Q
M
A
V
L
E
P
E
L
C
I
L
D
E
S
D
S
G
L
D
I
D
A
L
K
V
V
A
D
-
G
V
N
S
L
R
D
-
G
-
K
R
S
F
I
I
-
V
T
H
----
Y
Q
R
I
L
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.12
31%
-75
- C4 -
1VCI
1
?
A:
[23-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
N
----
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
--
E
P
T
---
E
G
R
I
Y
F
G
D
---
R
-
D
V
------------
T
Y
-
L
--
P
P
---
K
D
R
N
I
S
--
M
V
F
Q
-----------
H
M
T
-
V
Y
E
N
I
A
F
P
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
-
A
A
-----
E
L
L
Q
---
I
E
-------
E
-------
L
---------
L
----
N
R
----
Y
----
P
----
A
---
Q
----
L
--
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
Q
Q
-
K
-
L
K
V
T
T
I
Y
V
T
H
--------------
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------