@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1777: (2016-05-04 )
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
Atome Classification :
(28 SA)
.........10........20........30........40........50........60......---..70........80........90........100.......110.......120.......130.......140.......150.......160.---...-...170.......180.......190.......200.......210.......220.--......230.......240.......250.......-.260....---..---.-270--........280.......290.......300.......310.......320.--..--....330.......340.......350....-...360.......-370.......380.......390.......400.......410....----...420.......430..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRRSPKGSPG
A
V
L
D
L
Q
R
R
V
D
Q
A
VSA
D
H
A
E
L
M
T
I
AKDANTFFGAESVQDP
Y
P
L
Y
E
R
M
R
AAGS
V
H
RIAN---S
D
F
Y
A
V
C
G
W
D
A
V
N
E
AIGRPEDFSSN
L
T
A
T
M
T
Y
TAEGTAKPFEMDPLGGP
T
H
V
L
A
TADD
P
A
H
A
V
H
R
K
L
V
L
R
H
L
A
A
K
R
I
R
V
M
E
Q
F
T
V
Q
A
A
D
R
L
W
V
DGM---Q
D
G
-
C
I
E
W
M
G
A
M
A
NR
L
P
M
M
V
V
A
E
L
IGLP
D
P
D
I
A
Q
L
V
K
W
G
Y
A
A
T
Q
L
L
E
G
L
VEND
Q
L
V
A
A
G
V
A
--
L
M
E
L
S
G
Y
I
F
E
Q
F
D
R
AAAD
P
R
D
N
L
L
G
E
L
A
-
T
A
CASGE-
L
D
T
L
T
A
Q
V
---
M
M
---
V
-
T
L
---FAAGG
E
S
T
A
A
L
LGS
A
V
W
I
L
ATRP
D
I
Q
Q
Q
VRA
N
P
E
L
L
G
A
F
I
E
E
T
LRYEPPFRG--
H
Y
--
R
H
VRNATTLDGTELPADS
H
L
L
L
L
W
GAANRDP-AQFEAPG
E
F
R
L
DR-AGGKGHISFGKG
A
H
F
C
V
G
A
A
L
A
R
L
E
A
R
I
V
L
R
L
L
LDR
T
S
V
I
E
A
A
DVGG----
W
L
P
S
I
L
V
R
R
I
E
R
L
E
LAVQ
8
PsiBlast_PDB
99.62
32%
-117
- C5 -
2WHW
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
-
R
-
T
S
D
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
---
H
-
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
43
PsiBlast_CBE
98.87
32%
-115
- C5 -
2WHW
4
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
-
R
-
T
S
D
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
---
H
-
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
9
PsiBlast_PDB
98.29
32%
-116
- C5 -
2WI9
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
-
R
-
T
S
D
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
---
H
-
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GELV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
4
PsiBlast_PDB
98.22
32%
-110
- C5 -
3ZK5
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
10
PsiBlast_PDB
98.18
32%
-111
- C5 -
2BVJ
3
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
35
PsiBlast_CBE
98.03
32%
-112
- C5 -
4BF4
2
PIKC_STRVZ
C:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
LAA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GELV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
2
PsiBlast_PDB
97.97
32%
-109
- C5 -
2VZM
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
47
PsiBlast_CBE
97.92
32%
-113
- C5 -
2C6H
3
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
LAA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GELV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
38
PsiBlast_CBE
97.87
32%
-111
- C5 -
3ZPI
6
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
14
PsiBlast_PDB
97.79
32%
-111
- C5 -
2CD8
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
12
PsiBlast_PDB
97.79
32%
-111
- C5 -
2C7X
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
34
PsiBlast_CBE
97.68
32%
-110
- C5 -
4BF4
19
PIKC_STRVZ
D:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
LAA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GELV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
40
PsiBlast_CBE
97.61
32%
-111
- C5 -
2VZM
2
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
1
PsiBlast_PDB
97.57
32%
-111
- C5 -
2VZ7
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
7
PsiBlast_PDB
97.49
32%
-110
- C5 -
4UMZ
2
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
11
PsiBlast_PDB
97.48
32%
-112
- C5 -
2C6H
6
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
39
PsiBlast_CBE
97.44
32%
-109
- C5 -
3ZK5
2
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
3
PsiBlast_PDB
97.32
32%
-111
- C5 -
4B7S
14
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
21
PsiBlast_CBE
97.29
32%
-109
- C5 -
4UMZ
2
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PE
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
42
PsiBlast_CBE
97.24
32%
-113
- C5 -
2WI9
5
PIKC_STRVZ
B:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
AA
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
-
R
-
T
S
D
E
D
-
G
S
R
L
T
S
E
E
L
L
G
M
A
---
H
-
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GELV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
5
PsiBlast_PDB
96.76
32%
-111
- C5 -
3ZPI
13
PIKC_STRVZ
A:
[40-423]
----------------------------------------
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
PEG
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
-
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
E
A
---------
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
-
V
D
A
M
L
A
A
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
--
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
-
R
L
T
S
E
E
L
L
---
G
M
---
A
H
I
L
---
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A-
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
-
E
R
F
P
D
P
H
R
F
D
I
-
R
-
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
-
A
L
D
V
S
P
GE
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---
50
PsiBlast_CBE
83.55
31%
-98
- C5 -
3ZKP
2
ERYK_SACEN
A:
[53-373]
-------------------------------------------------------------------------------------
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
D
P
T
R
V
I
E
G
A
S
P
T
P
G
A
I
H
E
I
---
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
G
---
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
-
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
-
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
---
F
S
---
T
-
A
L
---
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
P
F
P
Q
--
M
Q
--
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
-
D
A
H
D
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
---------------------------------
53
PsiBlast_CBE
83.40
31%
-98
- C5 -
2JJO
2
ERYK_SACEN
A:
[53-373]
-------------------------------------------------------------------------------------
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
D
P
T
R
V
I
E
G
A
S
P
T
P
G
M
I
H
E
I
---
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
G
---
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
-
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
-
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
---
F
S
---
T
-
A
L
---
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
P
F
P
Q
--
M
Q
--
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
-
D
A
H
D
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
---------------------------------
51
PsiBlast_CBE
83.19
31%
-98
- C5 -
2XFH
4
ERYK_SACEN
A:
[53-373]
-------------------------------------------------------------------------------------
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
D
P
T
R
V
I
E
G
A
S
P
T
P
G
M
I
H
E
I
---
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
G
---
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
-
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
-
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
---
F
S
---
T
-
A
L
---
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
P
F
P
Q
--
M
Q
--
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
-
D
A
H
D
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
---------------------------------
52
PsiBlast_CBE
82.30
31%
-96
- C5 -
2JJP
3
ERYK_SACEN
A:
[53-373]
-------------------------------------------------------------------------------------
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
D
P
T
R
V
I
E
G
A
S
P
T
P
G
M
I
H
E
I
---
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
G
---
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
-
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
-
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
---
F
S
---
T
-
A
L
---
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
P
F
P
Q
--
M
Q
--
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
-
D
A
H
D
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
---------------------------------
67
PsiBlast_CBE
78.30
31%
-114
- C5 -
2Y5Z
6
MYCG_MICGR
C:
[103-386]
--------------------------------------------------------------------------------------------------------------------------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
-
V
D
Q
M
AA-
T
G
Q
-
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
-------
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
-
Q
A
--
R
D
Q
-
Q
D
S
L
S
E
Q
E
---
L
L
DLA
I
-
G
L
---
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
V
G
TA
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
-
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
-
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
---------------------------------
83
PsiBlast_CBE
75.82
32%
-111
- C5 -
1GWI
4
?
A:
[85-375]
-------------------------------------------------------------------------------------------------------------------
L
A
N
P
G
R
S
M
L
T
V
D
G
A
E
H
R
R
L
R
T
L
V
A
Q
A
L
T
V
R
R
V
E
H
M
R
G
R
I
T
E
L
T
D
R
L
L
D
E
L
P
---
A
D
G
G
V
V
D
L
K
A
A
F
A
Y
P
L
P
M
Y
V
V
A
D
L
M
G
I
E
E
---
A
R
L
P
R
L
K
V
L
F
E
K
F
F
S
T
Q
T
P
P
E
E
V
V
A
T
-----
L
T
E
L
A
S
I
M
T
D
T
V
A
A
K
R
A
A
P
G
D
D
L
T
S
A
L
I
-
Q
A
S
E
N
G
---
D
H
L
T
D
A
E
---
I
V
---
S
-
T
L
Q
L
M
V
A
A
G
H
E
T
T
I
S
L
I
V
N
A
V
V
N
L
S
T
H
P
E
Q
R
A
L
V
L
S
G
E
A
E
W
S
A
V
V
E
E
T
L
R
F
S
T
P
-
T
S
--
H
V
L
I
R
F
A
A
E
D
V
P
V
G
D
R
V
I
P
A
G
D
A
L
I
V
S
Y
G
A
L
G
R
D
E
R
A
H
G
P
T
A
D
R
F
D
L
T
R
-
T
S
G
N
R
H
I
S
F
G
H
G
P
H
V
C
P
G
A
A
L
S
R
M
E
A
G
V
A
L
P
A
L
Y
A
R
---------------------------------
82
PsiBlast_CBE
75.18
32%
-110
- C5 -
1GWI
5
?
B:
[85-375]
-------------------------------------------------------------------------------------------------------------------
L
A
N
P
G
R
S
M
L
T
V
D
G
A
E
H
R
R
L
R
T
L
V
A
Q
A
L
T
V
R
R
V
E
H
M
R
G
R
I
T
E
L
T
D
R
L
L
D
E
L
P
---
A
D
G
G
V
V
D
L
K
A
A
F
A
Y
P
L
P
M
Y
V
V
A
D
L
M
G
I
E
E
---
A
R
L
P
R
L
K
V
L
F
E
K
F
F
S
T
Q
T
P
P
E
E
V
V
A
T
-----
L
T
E
L
A
S
I
M
T
D
T
V
A
A
K
R
A
A
P
G
D
D
L
T
S
A
L
I
-
Q
A
S
E
N
G
---
D
H
L
T
D
A
E
---
I
V
---
S
-
T
L
QLM
V
A
A
G
H
E
T
T
I
S
L
I
V
N
A
V
V
N
L
S
T
H
P
E
Q
R
A
L
V
L
S
G
E
A
E
W
S
A
V
V
E
E
T
L
R
F
S
T
P
-
T
S
--
H
V
LI
R
F
A
A
E
D
V
P
V
G
D
R
V
I
P
A
G
D
A
L
I
V
S
Y
G
A
L
G
R
D
E
R
A
H
G
P
T
A
D
R
F
D
L
T
R
-
T
S
G
N
R
H
I
S
F
G
H
G
P
H
V
C
P
G
A
A
L
S
R
M
E
A
G
V
A
L
P
A
L
Y
A
R
---------------------------------