@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1794: (2016-05-05 )
MDQQSTRTDITVNVDGFWMLQALLDIRHVAPELRCRPYVSTDSNDWLNEHPGMAVMREQGIVVNDAVNEQVAARMKVLAAPDLEVVALLSRGKLLYGVIDDENQPPGSRDIPDNEFRVVLARRGQHWVSAVRVGNDITVDDVTVSDSASIAALVMDGLESIHHADPAAINAVNVPMEEMLEATKSWQESGFNVFSGGDLRRMGISAATVAALGQALSDPAAEVAVYARQYRDDAKGPSASVLSLKDGSGGRIALYQQARTAGSGEAWLAICPATPQLVQVGVKTVLDTLPYGEWKTHSRV
Atome Classification :
(20 SA)
------------------------------------.....--....10......-..20...-...--.--.30.....-...40....-----....50.....----...60..-...--.----..70--.........80-----.....------...-----------------90---------....-....100........110-.--........120.----......130.---....---------..140----...-------------.---.-----...---150..--...----..160---.---...-----....170...-------------------------.------.--------..180.---.....-----.190..---.-.-----.--------..200-........210.......220.......--230.-..-...--------..240.......250.....------..260-------...--------....270----.-----------...-...------------..280...---------....290........300--------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------MDQQS--TRT
D
I
T
V
NV
D
G
F
-
W
M
L
Q
A
L
L
-
D
I
R
--
H
--VA
P
E
LRCR-PYVSTDSND-----
W
L
N
EHPG
M
A
V
M
----
R
EQ
G
I
V
V-NDA--V----
N
E
Q
---
V
A
A
R
M
K
VLAAP-----
D
L
E
V
V
------
A
L
L
-----------------SR---------G
K
L
L
-
Y
G
V
IDD-ENQPPGSRD---I--PD
N
E
F
R
V
V
L
A
RR----G
Q
H
W
V
S
A
VRV---GN
D
I
---------
T
V
D
D
-----
V
TV-------------S---D-----S
A
S
---
I
A
A
L
V
--
M
D
G
----
L
E
S
I
----H---HAD-----PAAINAVNV
P
-------------------------
M
------
E
--------
E
M
L
E
A
T
---
K
S
W
Q
E
-----SG
F
N
VF---S-G-----G--------D
L
R
R
--MG
I
S
A
A
T
V
A
A
L
G
Q
A
LSD
P
A
A
E
V
A
V
Y
A
R
Q
--YR-D-DA-KGP--------S
A
S
V
L
S
L
KDGSG
G
R
I
A
L
Y
Q
Q------ARTAG-------SG
E
--------
A
W
L
A
I------C-----------PA
T
-
P
Q
L
------------
V
Q
V
G
V
K
T
V
---------
L
DTLP-YGEWKTHSRV----------------------------------------
1
PsiBlast_PDB
99.08
100%
-131
- C6 -
4W4L
-
ESPG5_MYCTU
C:
[6-300]
-------------------------------------------
T
R
T
D
I
T
V
N
V
D
G
F
-
W
M
L
Q
A
L
L
-
D
I
R
--
H
--
V
A
P
E
L
R
C
R
-
P
Y
V
S
T
D
S
N
D
-----
W
L
N
E
H
P
G
M
A
V
M
----
R
E
Q
G
I
V
V
-
N
D
A
--
V
----
N
E
Q
---
V
A
A
R
M
K
V
L
A
A
P
-----
D
L
E
V
V
------
A
L
L
-----------------
S
R
---------
G
K
L
L
-
Y
G
V
I
D
D
-
E
N
Q
P
P
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S
R
D
---
I
--
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D
N
E
F
R
V
V
L
A
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R
----
G
Q
H
W
V
S
A
V
R
V
---
G
N
D
I
---------
T
V
D
D
-----
V
T
V
-------------
S
---
D
-----
S
A
S
---
I
A
A
L
V
--
M
D
G
----
L
E
S
I
----
H
---
H
A
D
-----
P
A
A
I
N
A
V
N
V
P
-------------------------
M
------
E
--------
E
M
L
E
A
T
---
K
S
W
Q
E
-----
S
G
F
N
V
F
---
S
-
G
-----
G
--------
D
L
R
R
--
M
G
I
S
A
A
T
V
A
A
L
G
Q
A
L
S
D
P
A
A
E
V
A
V
Y
A
R
Q
--
Y
R
-
D
-
D
A
-
K
G
P
--------
S
A
S
V
L
S
L
K
D
G
S
G
G
R
I
A
L
Y
Q
Q
------
A
R
T
A
G
-------
S
G
E
--------
A
W
L
A
I
------
C
-----------
P
A
T
-
P
Q
L
------------
V
Q
V
G
V
K
T
V
---------
L
D
T
L
P
-
Y
G
E
W
K
T
H
S
R
V
----------------------------------------
14
Fugue
97.06
100%
-140
- C6 -
4KXR
-
ESPG5_MYCTU
C:
[8-298]
---------------------------------------------
T
D
I
T
V
N
V
D
G
F
-
W
M
L
Q
A
L
L
-
D
I
R
--
H
--
V
A
P
E
L
R
C
R
-
P
Y
V
---------------
H
P
G
M
A
V
M
----
R
E
Q
G
I
V
V
-
N
D
A
--
V
----
N
E
Q
---
V
A
A
R
M
K
V
L
A
A
P
-----
D
L
E
V
V
------
A
L
L
-----------------
S
R
---------
G
K
L
L
-
Y
G
V
I
D
D
-
E
N
Q
P
P
G
S
R
D
---
I
--
P
D
N
E
F
R
V
V
L
A
R
R
----
G
Q
H
W
V
S
A
V
R
V
---
G
N
D
I
---------
T
V
D
D
-----
V
T
V
-------------
S
---
D
-----
S
A
S
---
I
A
A
L
V
--
M
D
G
----
L
E
S
I
----
H
---
H
A
D
-----
P
A
A
I
N
A
V
N
V
P
-------------------------
M
------
E
--------
E
M
L
E
A
T
---
K
S
W
Q
E
-----
S
G
F
N
V
F
---
S
-
G
-----
G
--------
D
L
R
R
--
M
G
I
S
A
A
T
V
A
A
L
G
Q
A
L
S
D
P
A
A
E
V
A
V
Y
A
R
Q
--
Y
R
-
D
-
D
A
-
K
G
P
--------
S
A
S
V
L
S
L
K
D
G
S
G
G
R
I
A
L
Y
Q
Q
------
A
R
------------
E
--------
A
W
L
A
I
------
C
-----------
P
A
T
-
P
Q
L
------------
V
Q
V
G
V
K
T
V
---------
L
D
T
L
P
-
Y
G
E
W
K
T
H
S
------------------------------------------
2
PsiBlast_PDB
97.06
100%
-140
- C6 -
4KXR
-
ESPG5_MYCTU
C:
[8-298]
---------------------------------------------
T
D
I
T
V
N
V
D
G
F
-
W
M
L
Q
A
L
L
-
D
I
R
--
H
--
V
A
P
E
L
R
C
R
-
P
Y
V
---------------
H
P
G
M
A
V
M
----
R
E
Q
G
I
V
V
-
N
D
A
--
V
----
N
E
Q
---
V
A
A
R
M
K
V
L
A
A
P
-----
D
L
E
V
V
------
A
L
L
-----------------
S
R
---------
G
K
L
L
-
Y
G
V
I
D
D
-
E
N
Q
P
P
G
S
R
D
---
I
--
P
D
N
E
F
R
V
V
L
A
R
R
----
G
Q
H
W
V
S
A
V
R
V
---
G
N
D
I
---------
T
V
D
D
-----
V
T
V
-------------
S
---
D
-----
S
A
S
---
I
A
A
L
V
--
M
D
G
----
L
E
S
I
----
H
---
H
A
D
-----
P
A
A
I
N
A
V
N
V
P
-------------------------
M
------
E
--------
E
M
L
E
A
T
---
K
S
W
Q
E
-----
S
G
F
N
V
F
---
S
-
G
-----
G
--------
D
L
R
R
--
M
G
I
S
A
A
T
V
A
A
L
G
Q
A
L
S
D
P
A
A
E
V
A
V
Y
A
R
Q
--
Y
R
-
D
-
D
A
-
K
G
P
--------
S
A
S
V
L
S
L
K
D
G
S
G
G
R
I
A
L
Y
Q
Q
------
A
R
------------
E
--------
A
W
L
A
I
------
C
-----------
P
A
T
-
P
Q
L
------------
V
Q
V
G
V
K
T
V
---------
L
D
T
L
P
-
Y
G
E
W
K
T
H
S
------------------------------------------
5
HHSearch
95.34
93%
-121
- C6 -
4W4L
-
ESPG5_MYCTU
C:
[6-300]
-------------------------------------------
T
R
T
D
I
T
V
N
V
D
G
F
-
W
M
L
Q
A
L
L
-
D
I
R
--
H
--
V
A
P
E
L
R
C
R
-
P
Y
V
S
T
D
S
N
D
-----
W
L
N
E
H
P
G
M
A
V
M
----
R
E
Q
G
I
V
V
-
N
D
A
--
V
----
N
E
Q
---
V
A
A
R
M
K
V
L
A
A
P
-----
D
L
E
V
V
------
A
L
L
-----------------
S
R
---------
G
K
L
L
-
Y
G
V
I
D
D
-
E
N
Q
P
P
G
S
R
D
---
I
--
P
D
N
E
F
R
V
V
L
A
R
R
----
G
Q
H
W
V
S
A
V
R
V
---
G
N
D
I
---------
T
V
D
D
-----
V
T
V
-------------
S
D
S
A
S
-----
I
A
A
-----
L
-
V
---------
M
D
G
L
----
E
S
I
H
H
A
D
-----
P
A
A
I
N
A
V
N
V
P
-------------------------
M
------
E
--------
E
M
L
E
A
T
---
K
S
W
Q
E
-----
S
G
F
N
V
F
---
S
-
G
-----
G
--------
D
L
R
R
--
M
G
I
S
A
A
T
V
A
A
L
G
Q
A
L
S
D
P
A
-
A
E
V
A
V
Y
A
R
--
Q
Y
-
R
D
D
A
-
K
G
P
--------
S
A
S
V
L
S
L
K
D
G
S
G
G
R
I
A
L
Y
Q
Q
------
A
R
T
A
G
-------
S
G
E
--------
A
W
L
A
I
------
C
-----------
P
A
T
-
P
Q
L
------------
V
Q
V
G
V
K
T
V
---------
L
D
T
L
P
-
Y
G
E
W
K
T
H
S
R
V
----------------------------------------
7
HHSearch
61.47
18%
-105
- C6 -
5DLB
20
?
A:
[22-301]
--------------------------------------------
P
N
A
V
E
L
T
V
E
N
A
-
W
F
I
A
E
M
V
-
G
A
G
--
T
--
F
P
W
V
L
A
I
T
-
T
P
Y
S
D
E
A
Q
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-----
S
A
F
F
A
R
Q
R
D
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----
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Q
L
G
L
L
S
S
D
G
V
--
V
----
N
P
A
---
V
A
E
W
I
K
V
V
C
F
P
-----
E
R
W
L
D
------
L
R
Y
-----------------
V
G
---------
P
-----------------------------
L
L
R
G
I
V
A
Q
S
AGIM-
F
N
T
V
V
A
L
R
N
---
A
Q
L
V
---------
T
F
T
A
-----
M
D
I
-------------
D
---
D
------
P
R
-----
A
-
L
---------
V
P
V
L
G
V
GL
S
---
A
R
P
-----
P
A
R
F
E
E
F
S
M
P
-------------------------
M
------
R
--------
V
G
A
R
A
D
---
E
R
L
R
S
--------
G
E
S
---
L
-
D
-----
E
--------
V
L
D
Y
--
L
G
I
P
V
S
A
R
P
V
V
Q
A
V
F
S
G
P
R
-
S
Y
V
E
I
V
A
G
--
C
N
R
D
-
G
E
-
H
T
T
--------
T
D
V
G
L
S
I
V
D
T
T
A
G
R
V
L
V
S
P
--------
S
R
A
F
-------
D
G
E
--------
W
V
S
T
F
------
S
-----------
A
G
T
-
P
F
A
------------
T
A
V
A
I
D
Q
L
---------
I
A
N
L
P
-
D
G
Q
W
F
---------------------------------------------
3
PsiBlast_PDB
55.51
23%
-70
- C6 -
4W4I
1
ESPG3_MYCTU
A:
[73-293]
------------------------------------------------------------------------------------------------------
M
G
L
L
----
S
P
Q
G
V
I
------------
N
P
A
---
V
A
D
W
I
K
V
V
C
F
P
-----
D
R
W
-----------------------------------------------
L
D
L
-
R
Y
V
G
P
A
S
A
D
---
G
--
A
C
E
L
L
R
G
I
V
A
L
R
----
T
G
T
G
K
---
K
T
---
G
N
G
V
V
A
L
R
N
AQ
L
V
T
F
T
A
-----
M
D
I
-------------
D
---
D
-----
P
R
A
---
L
V
P
I
L
--
G
V
G
----
L
A
----------
H
R
P
-----
P
A
R
F
D
E
F
S
L
P
-------------------------
T
------
R
--------
V
G
A
R
A
D
---
E
R
L
R
S
--------
G
V
P
---
L
-
G
-----
E
--------
V
V
D
Y
--
L
G
I
P
A
S
A
R
P
V
V
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S
V
F
S
G
P
R
S
Y
V
E
I
V
A
G
C
--
N
R
-
D
-
G
R
-
H
T
T
--------
T
E
V
G
L
S
I
V
D
T
S
A
G
R
V
-
L
V
S
P
------
S
R
-
A
F
-------
D
G
E
--------
W
V
S
T
F
------
S
-----------
P
G
T
-
P
F
A
------------
I
A
V
A
I
Q
T
L
---------
T
A
C
L
P
-
D
-------------------------------------------------
4
PsiBlast_PDB
49.24
23%
-83
- C6 -
5DLB
17
?
A:
[142-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
R
N
---
A
Q
L
V
---------
T
F
T
A
-----
M
D
I
-------------
D
---
D
-----
P
R
A
---
L
V
P
V
L
--
G
V
G
----
L
S
A
----------
R
P
-----
P
A
R
F
E
E
F
S
M
P
-------------------------
M
R
V
G
A
R
A
D
--------
E
R
L
R
S
G
---
E
S
L
D
E
-----
V
--------------------------
L
D
Y
--
L
G
I
P
V
S
A
R
P
V
V
Q
A
V
F
S
G
P
R
S
Y
V
E
I
V
A
G
C
--
N
R
-
D
-
G
E
-
H
T
T
--------
T
D
V
G
L
S
I
V
D
T
T
A
G
R
V
-
L
V
S
P
------
S
R
-
A
F
-------
D
G
E
--------
W
V
S
T
F
------
S
-----------
A
G
T
-
P
F
A
------------
T
A
V
A
I
D
Q
L
---------
I
A
N
L
P
-
D
G
Q
W
F
---------------------------------------------
6
HHSearch
45.96
17%
-45
- C6 -
4L4W
-
ESPG3_MYCS2
A:
[2-265]
-------------------------------------------
G
P
N
A
V
E
L
T
T
D
Q
A
-
W
C
L
A
D
V
L
-
G
A
G
--
S
--
Y
P
W
V
L
A
I
T
-
P
P
Y
S
D
H
S
Q
R
-----
S
A
F
L
A
A
Q
S
A
E
L
----
T
R
M
G
V
V
N
S
A
G
A
--
V
----
D
P
R
---
V
A
Q
W
I
T
T
V
C
R
A
-----
T
Q
W
L
D
------
L
R
F
-----------------
V
----------------------------------------
L
L
R
G
M
V
A
R
R
----
S
E
E
T
V
V
A
L
R
N
---
A
Q
L
V
---------
T
F
T
A
-----
M
D
I
-------------
G
HQH
A
-----
L
V
P
-----
V
-
L
---------
T
A
G
L
----
S
---
G
R
K
-----
P
A
R
F
D
D
F
A
L
P
-------------------------
A
------
A
--------
A
G
A
R
A
D
---
E
Q
I
R
N
--------
G
A
P
---
L
-
A
-----
E
--------
V
L
E
F
--
L
G
V
P
P
S
A
R
P
L
V
E
S
V
F
D
G
R
R
-
T
Y
V
E
I
V
A
G
--
E
H
-
R
-
D
G
H
R
V
T
--------
T
E
V
G
V
S
I
I
D
T
P
H
G
R
I
L
V
H
P
--------
T
K
A
F
-------
D
G
E
--------
W
I
S
T
F
------
T
-----------
P
G
S
-
A
D
A
------------
I
A
M
A
V
E
R
L
---------
T
A
S
L
P
-
S
G
S
W
F
---------------------------------------------
22
Fugue
39.35
17%
-43
* C5 *
4WL2
-
?
A:
[1-346]
--------------------------------C
T
R
F
V
Y
L
D
P
--
H
N
P
D
Y
P
I
T
A
R
S
M
D
W
A
D
D
T
E
T
-
N
L
W
--
I
--
F
P
Q
E
L
K
R
S
-
G
G
A
G
Q
Y
S
L
E
-----
W
T
S
K
Y
G
S
V
I
A
S
A
FDG
R
K
G
M
A
S
T
-
T
D
G
--
V
----
N
E
K
G--
L
A
A
N
V
L
W
L
A
E
S
-----
E
Y
P
K
T
KPTAK
K
P
G
L
-----------------
S
V
---------
A
A
W
A
-
Q
Y
V
L
D
N
F
A
T
V
D
E
A
V
K
S
---
L
--
Q
Q
E
K
F
I
L
V
T
K
Q
------------
V
E
G
---
Q
K
R
L
---------
A
T
L
H
-----
L
S
L
-------------
S
---
D
-----
S
S
G
---
D
S
A
I
I
E
Y
I
D
G
----
K
Q
V
I
----
H
---
H
S
K
-----
N
Y
Q
V
M
T
N
S
P
T
-------------------------
F
------
D
--------
Q
Q
L
T
L
N
---
A
Y
W
D
Q
-----
I
G
G
N
V
M
L
P
G
T
-
N
-----
R
--------
A
A
D
R
--
F
V
R
A
S
F
Y
V
K
N
V
N
P
N
K
L
I
P
G
----
V
A
E
K
G
--
K
I
-
E
-
K
D
-
K
A
D
--------
L
A
T
A
F
S
I
I
R
N
A
S
V
P
Y
G
Y
S
L
P
------
D
M
P
N
I
-------
A
S
T
--------
R
W
R
T
V
------
V
DHKSL
Q
Y
F
F
E
S
A
V
S
-
P
N
I
------------
F
W
V
D
L
K
K
I
NFAPRGG
S
-
A
A
K
L
D
-
L
G
P
N
Q
S
T
I
Y
S
GQASGH
F
K
P
A
Q
PFEFAG-----------------------
19
Fugue
37.15
24%
-40
- C3 -
4Q98
1
FIMA_PORGI
A:
[9-365]
--------------------------------------
V
V
E
--
T
N
A
T
V
S
F
I
I
K
S
G
-
E
S
R
A
V
G
D
-
D
L
T
--
D
--
A
K
I
T
K
L
T
A
M
V
Y
A
G
Q
V
Q
E
G
-----
I
K
T
V
E
E
D
G
G
V
L
----
K
V
E
G
I
P
C
-
K
S
G
--
A
----
N
R
V
L
V
V
V
A
N
H
N
Y
E
L
T
G
K
-----
S
L
N
E
V
------
E
A
L
-----------------
T
T
S
L
T
A
E
N
Q
N
A
K
N
L
I
M
T
G
K
S
A
A
-
F
T
I
K
P
G
S
N
H
---
Y
GY
P
G
G
T
A
S
D
N
L
V
S
A
----
G
T
P
L
-
A
V
T
R
V
---
H
A
G
I
---------
S
F
A
G
-----
V
E
V
N
M
A
TQYQN
Y
Y
S
F
K
P
---
A
-----
D
A
K
---
I
A
A
L
V
--
A
K
K
----
D
S
K
I
----
F
---
G
N
S
LVSNT
N
A
Y
L
Y
G
V
Q
T
P
-------------------------
A
------
G
LYTPDAAG
E
T
Y
E
L
E
---
A
S
L
N
T
NYAVG
A
G
F
Y
V
L
---
E
-
S
K
YDAS
N
--------
E
L
R
P
T
I
L
C
I
Y
G
K
L
L
D
K
D
G
N
P
L
T
E
P
A
L
T
D
A
I
N
A
G
---
F
C
-
D
-
G
D
-
G
T
T
--------
Y
Y
P
V
L
V
N
Y
D
G
N
G
---
Y
I
Y
S
G
------
A
I
T
Q
G
-------
Q
N
K
I
V
R
N
N
H
Y
K
I
S
L
N
I
TGPGTN
T
-----------
P
E
N
-
P
Q
P
------------
V
Q
A
N
L
N
V
T
---------
C
Q
V
T
P
----
W
V
V
V
N
Q
-----------------------------------------
20
Fugue
35.58
17%
-78
- C4 -
1Q2Y
-
YJCF_BACSU
A:
[1-140]
------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
I
A
K
-----
N
E
E
Q
L
------
K
D
A
-----------------
F
Y
---------
V
R
E
E
-
V
F
V
K
E
Q
-
N
V
P
A
E
E
E
I
D
---
E
--
L
E
N
E
S
E
H
I
V
V
Y
D
----
G
E
K
P
V
G
A
G
R
W
R
M
K
D
G
Y
G
---------
K
L
E
R
-----
I
C
V
-------------
L
---
K
-----
S
H
R
SAG
V
G
G
I
I
--
M
K
A
----
L
E
K
A
----
A
---
A
D
G
-----
G
A
S
----
G
F
I
-------------------------
L
------
N
--------
A
Q
T
Q
A
V
---
P
F
Y
K
K
-----
H
G
Y
R
V
L
---
S
-
E
-----
K
--------
E
F
L
D
--
A
G
I
P
H
L
Q
M
M
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
33.77
9%
-56
- C2 -
1RLV
-
ENDA_ARCFU
A:
[2-305]
-----------------------IGGD
F
A
V
V
KAK
K
S
L
E
R
R
G
FG
V
K
R
G
D
K
I
Y
L
H
P
L
-
E
V
V
Y
L
Q
I
K
G
I
E
--
S
--
F
G
E
L
E
D
V
L
-
S
W
A
E
S
R
M
E
D
-----
F
S
T
Y
Y
F
V
Y
E
D
L
----
R
D
R
G
N
K
V
-
K
I
Q
GE
F
----
L
L
T
---
K
K
P
Y
L
P
I
S
E
R
K
-----
T
I
R
M
E
------
E
I
A
-----------------
E
K
---------
A
R
N
F
-
D
E
L
R
L
A
-
V
V
D
E
E
S
E
I
T
---
Y
--
F
R
V
Y
E
P
D
M
M
G
E
Q
----
K
E
E
L
P
E
I
A
G
V
LS-
D
E
Y
V
---------
I
T
K
Q
-----
T
E
I
-------------
F
---
S
RYFYG
S
E
K
---
G
D
L
V
T
--
L
S
L
----
I
E
S
L
----
Y
---
L
L
D
-----
L
G
K
L
N
L
L
N
A
D
-------------------------
R
------
E
--------
E
L
V
K
R
A
---
R
E
V
E
R
-----
N
F
D
R
R
Y
---
E
V
Y
-----
R
--------
N
L
K
E
--
R
G
F
V
V
K
T
G
F
K
F
G
-------
S
E
F
R
V
Y
R
K
V
--
E
S
-
V
-
D
D
-
L
P
H
--------
S
E
Y
L
V
D
I
A
D
S
R
E
I
R
L
I
D
L
A
R
------
A
V
R
L
A
-------
Q
N
V
--------
R
K
R
M
V
------
F
-----------
A
Y
G
-
K
N
Y
------------
L
C
F
E
R
V
K
V
-----------------------------------------------------------------
23
Fugue
32.00
16%
-36
- C5 -
4WZI
5
PDE4B_HUMAN
A:
[85-576]
---------------------VT
P
F
A
Q
V
L
A
S
L
R
S
V
R
N
N
F
T
I
--
Q
K
L
A
M
E
T
L
E
E
L
D
-
W
A
L
D
Q
L
E
-
T
I
Q
T
Y
R
--
S
V
S
E
M
A
S
N
-
K
F
K
R
M
L
N
R
E
-----
L
T
H
L
S
E
M
S
R
C
G
----
N
Q
V
S
E
Y
I
-
S
N
T
--
F
LD--
K
E
N
---
E
D
H
L
A
K
E
L
E
D
L
NKWGL
N
I
F
N
V
------
A
G
Y
-----------------
S
H
---------
N
R
P
L
-
T
A
I
M
Y
A
-
I
F
Q
E
R
D
L
L
K
T
F
R
I
--
S
S
D
T
F
I
T
Y
M
M
T
L
----
E
D
H
Y
H
S
D
V
A
Y
---
H
N
S
L
---------
H
A
A
D
-----
V
A
Q
-------------
S
---
T
-----
H
V
L
---
L
S
T
P
A
--
L
D
A
VFT
D
L
E
I
L
----
A
---
A
I
F
-----
A
A
A
I
H
D
V
D
H
P
GVS
N
Q
F
L
I
N
T
NS
E
L
A
L
M
Y
NDES
V
L
E
N
------
H
--------
H
L
A
V
G
F
---
K
L
L
Q
E
-----
E
H
A
D
I
F
---
M
-
N
L----
T
--------
K
K
Q
R
--
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
--
M
V
-
E
-
T
K
-
K
V
T
--------
S
S
G
V
L
L
L
D
N
-
Y
T
D
R
I
Q
V
L
R
N
------
M
V
H
A
A
D
L
SNPTK
S
L
E
--------
L
Y
R
Q
W
------
T
-----------
D
R
I
M
E
E
F
------------
F
Q
Q
G
D
K
E
R
E
R
GMEISPM
A
D
K
H
T
-
A
C
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
QPDA
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
IP-
18
Fugue
25.28
14%
-36
- C1 -
4L6Y
-
PRC1_HUMAN
A:
[2-450]
R
R
S
E
V
L
A
E
E
S
I
V
C
L
Q
K
A
L
N
H
L
R
E
I
W
E
L
I
GIP
E
D
Q
R
L
Q
R
T
E
V
--
V
K
K
H
I
K
E
L
L
D
M
M
-
I
A
E
E
E
S
L
-
K
E
R
--
L
--
I
K
S
I
S
V
C
Q
-
K
E
L
N
T
L
C
S
E
L
H
V
E
P
F
Q
E
E
G
E
T
T
I
L
Q
----
L
E
K
D
L
R
T
-
Q
V
E
--
L
M
R
K
Q
K
K
E
---
R
K
Q
E
L
K
L
L
Q
E
Q
-----
D
Q
E
L
C
------
E
I
L
CMPHYDIDSASVPS
L
E
E
L
N
---------
Q
F
R
Q
-
H
V
T
T
L
R
-
E
T
K
A
S
R
R
E
E
---
F
--
V
S
I
K
R
Q
I
I
L
C
M
E
----
E
L
D
H
T
P
D
T
S
F
---
E
R
D
V
---------
V
C
E
D
EDAFC
L
S
L
-------------
E
---
N
-----
I
A
T
---
L
Q
K
L
L
--
R
Q
-----
L
E
M
Q
----
K
---
S
Q
N
-----
E
A
V
C
E
G
L
R
T
Q
-------------------------
I
------
R
--------
E
L
W
D
R
L
QIP
E
E
E
R
E
-----
A
V
A
T
I
M
---
S
-
G
-----
S
KAK
V
R
K
A
L
Q
L
E
V
--
D
R
L
E
E
L
K
M
Q
N
M
K
K
V
I
E
A
I
R
V
E
L
V
Q
Y
W
D
Q
CF
Y
S
-
Q
-
E
Q
-
R
Q
A
FAPFCAEY
T
E
S
L
L
Q
L
H
D
A
E
I
V
R
L
K
N
Y
Y
E
V
H
K
E
L
F
E
G
V
Q
K
-------
W
E
E
--------
T
W
R
L
F
------
L
-----------
E
F
E
-
R
K
A
S
DPNRRGGN
L
L
K
E
E
K
Q
R
A
K
L
---------
Q
K
M
L
P
-
K
L
E
E
E
L
K
A
R
I
E
L
W
E
Q
EHSK
A
F
M
V
NGQKFM
E
Y
V
A
E
Q
W
E
M
H
R
L
E
K
E
R
A
K
Q
E
R
11
HHSearch
16.63
24%
192
- C6 -
2EBE
-
?
A:
[77-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
E
------------
A
A
E
A
L
G
E
V
---------
L
E
G
L
P
P
E
V
G
W
L
---------------------------------------------
9
HHSearch
15.47
16%
44
- C6 -
3JAM
-
?
K:
[65-91]
----------------------------------------------
Y
Y
T
L
T
E
E
G
V
-
V
Y
L
R
E
Y
L
-
N
L
P
--
E
HI
F
P
A
T
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
13.34
24%
111
- C6 -
2LTD
-
?
A:
[51-71]
-------------------------------------------
M
G
K
G
I
T
L
S
E
E
E
F
-
G
V
L
L
K
E
L
-
G
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
12.47
20%
130
- C6 -
3PM7
-
?
A:
[51-70]
-------------------------------------------
M
G
K
G
I
T
L
T
N
E
E
F
-
A
E
L
S
K
T
I
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
11.30
15%
121
- C6 -
4G06
2
?
A:
[58-77]
-------------------------------------------
M
G
K
G
I
T
L
S
N
E
E
F
-
Q
T
M
V
D
A
F
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
10.37
15%
133
* C6 *
2L3A
-
?
A:
[53-72]
-------------------------------------------
M
G
K
G
I
T
L
S
N
E
E
F
-
Q
T
M
V
D
A
F
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------