@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1819c: (2016-05-05 )
MGPKLFKPSIDWSRAFPDSVYWVGKAWTISAICVLAILVLLRYLTPWGRQFWRITRAYFVGPNSVRVWLMLGVLLLSVVLAVRLNVLFSYQGNDMYTALQKAFEGIASGDGTVKRSGVRGFWMSIGVFSVMAVLHVTRVMADIYLTQRFIIAWRVWLTHHLTQDWLDGRAYYRDLFIDETIDNPDQRIQQDVDIFTAGAGGTPNAPSNGTASTLLFGAVQSIISVISFTAILWNLSGTLNIFGVSIPRAMFWTVLVYVFVATVISFIIGRPLIWLSFRNEKLNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVIDNYRRYVRRSIAFNGWNLSVSQTIVPLPWVIQAPRLFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAIIRLHGLVDANEKGRALPAVLTRPSDDESVELNDIEVRTPAGDRLIDPLDVRLDRGGSLVITGRSGAGKTTLLRSLAELWPYASGTLHRPGGENETMFLSQLPYVPLGTLRDVVCYPNSAAAIPDATLRDTLTKVALAPLCDRLDEERDWAKVLSPGEQQRVAFARILLTKPKAVFLDESTSALDTGLEFALYQLLRSELPDCIVISVSHRPALERLHENQLELLGGGQWRLAPVEAAPAEV
Atome Classification :
(20 SA)
--------------------.......------..10.......-.20........30........40........50........60........70........80........90........100.......110......-.-120...---....130----.----.----.....140.......150.......160.......170.......180.......190.......200.......210-........220.......230........240........250.......260........270.......280.......290.....--..300.......310.......320-....---...330..--.....340.......350.......360-........370.----......380.......390.......400..--.....---410-...-.----...420.....-....430...-....--440-........450.......460.......470........480-.........----------490.......----500---....-...510......-.520.......-------530-.........540.-----....-----..550------------.........560.......570.......580.......590...--..--..600...--....610.......-.620.......630.-.-...-..-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------MGPKLFK------PSIDWSRAFPD-S
V
Y
W
VGK
A
W
T
I
S
A
I
C
V
L
A
I
L
V
L
L
R
YL
T
P
W
G
R
Q
F
W
R
I
T
R
A
Y
F
VGP
N
S
V
R
V
W
L
M
L
G
V
L
L
L
S
V
V
L
A
V
R
L
N
V
L
F
S
YQG
N
D
M
Y
T
A
L
Q
K
A
F
E
G
IASGDG
T
V
KRSGV-
R
-
G
F
W
M
S
I
---
G
V
F
S
V
M
A
----
V
----
L
----
H
V
T
R
V
M
A
D
I
Y
L
T
Q
R
F
I
I
A
W
R
V
W
L
T
H
H
L
T
Q
D
W
LDG
R
A
Y
Y
R
D
LFIDETID
N
P
D
Q
R
I
Q
Q
DV
D
I
F
TAGAGGTPNAPSNG
T
A
--
S
T
L
L
F
G
A
V
Q
S
I
I
S
V
I
S
F
T
A
-
I
L
WNLSG
T
L
N
I
-
F
GVSI
P
R
A
M
F
W
T
V
L
V
Y
V
F
V
A
-
T
V
I
S
F
I
IGR
P
L
I
W
L
S
FRNEK
L
N
A
A
F
R
Y
A
L
V
R
L
R
D
A
A
--
E
A
V
G
FYRGERVE
G
T
Q
L
Q
R
R
F
T
P
V
I
D
-
N
Y
R
R
---
Y
V
R
R
S
IAF--NGW
N
L
S
VSQ
T
I
VPLP
W
V
IQAPR
L
F
AGQ--IDFGDVG
Q
T
A
T
S----FG
N
I
H
D
S
L
S
F
F
R
N
N
Y
D
A
F
A
S
F
R
A
A
I
I
R
L
HGL--VDANE---KGR-AL
P
-
A
----
V
LTR--PSDDE-
S
V
E
L
N
D
I
E
V
R-TPAG--DR--LIDPL
D
V
R
LDRG
G
S
L
V
I
TGRSGA
G
K
T
T
L
L
R
-
S
L
A
E
LWPYA---SGTLHRPGG----------EN
E
T
M
F
L
SQL----PYV---P
L
G
T
-LRDVVCYPNSAA-AIP
D
A
T
L
R
D
T
L
-------
T
---
K
V
A
L
A
P
L
C
D
R
LDE-----
E
R
D
W
-----
A
K
V--------------LSPG
E
Q
Q
R
V
A
F
A
R
I
L
LTKP
K
A
V
F
LDEST
S
A
L
D
T
G
L
E
F
A
L
Y
Q
L
L
R
S
--EL--P
D
C
I
V
I
SV--SH
R
P
A
-
L
E
R
L
H
E
N
Q
-
L
E
LLGGG
Q
W
R
L
APVE-A-APA-EV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.94
26%
-80
- C4 -
4MYC
-
ATM1_YEAST
A:
[212-632]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
V
F
H
I
I
P
-
I
S
F
E
I
-
S
V
--
V
C
G
I
L
T
Y
Q
F
G
A
S
F
A
A
I
T
F
S
T
M
L
L
Y
S
I
-------
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
----
L
A
D
K
Y
N
G
S
L
M
-
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
-
M
G
C
T
G
V
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
----
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
---
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
VK
I
K
N
A
-
E
R
P
-
L
----
M
L
P
E
N
V
P
Y
D
----
I
T
F
E
N
V
T
F
G
-
Y
H
P
D
--
R
K
--
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
-
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
----------
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
---
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
-
G
R
I
D
A
T
D
E
E
V
I
-------
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
-----
G
F
D
T
I
V
G
ER
G
L
M
--------------
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
--
N
F
--
T
S
G
S
R
T
S
V
Y
I
A
H
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.83
26%
-79
- C4 -
4MYH
-
ATM1_YEAST
A:
[115-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
V
F
H
I
I
P
-
I
S
F
E
I
-
S
V
--
V
C
G
I
L
T
Y
Q
F
G
A
S
F
A
A
I
T
F
S
T
M
L
L
Y
S
I
-------
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
----
L
A
D
K
Y
N
G
S
L
M
-
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
-
M
G
C
T
G
V
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
----
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
---
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
VK
I
K
N
A
-
E
R
P
-
L
----
M
L
P
E
N
V
P
Y
D
----
I
T
F
E
N
V
T
F
G
-
Y
H
P
D
--
R
K
--
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
-
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
----------
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
---
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
-
G
R
I
D
A
T
D
E
E
V
I
-------
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
-----
G
F
D
T
I
V
G
ER
G
L
M
--------------
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
--
N
F
--
T
S
G
S
R
T
S
V
Y
I
A
H
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
78.70
18%
-78
- C4 -
3ZDQ
6
ABCBA_HUMAN
A:
[33-558]
-------------------------------------------------------------------------------------------------------------
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-----------
V
D
Y
S
D
-
N
L
T
R
L
C
---
L
G
L
S
A
V
F
----
L
C
G
A
A
A
----
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
---
E
V
A
F
F
D
----
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
--------------
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
-
M
M
F
F
V
S
P
N
L
A
T
-
F
-----------
V
L
S
V
V
P
P
V
-
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
--
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
-
L
A
R
K
---
E
A
F
A
R
A
G
F
--
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
--
M
T
V
G
E
L
S
S
F
L
M
Y
----
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
--
L
E
R
E
P
---
K
L
P
-
F
N
E
-
G
V
---
I
L
N
E
--
K
S
F
Q
G
-
A
L
E
F
K
N
V
H
F
A
-
Y
P
A
R
PE
V
P
--
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
-
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
DIRQLN
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
----
P
I
L
---
F
S
C
S
-
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
-------
E
---
V
A
N
A
V
A
F
I
R
N
F
P
Q
GFN
T
V
V
G
E
K
-----
G
V
L
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
--
L
M
--
D
G
R
T
V
L
V
I
--
A
H
R
L
S
-
T
I
K
N
A
N
M
V
-
A
V
L
D
Q
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
78.31
17%
-79
- C4 -
4MRS
12
ATM1_NOVAD
A:
[46-572]
--------------------------------------------------------------------------------------------------------
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
-------------
G
G
A
-
Q
P
A
L
T
V
A
L
A
F
V
L
A
Y
A
L
G
R
F
S
G
V
L
----
F
----
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
---
S
L
R
F
H
L
----
A
R
R
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
L
Y
--------------
F
L
L
F
N
I
A
P
T
V
I
E
L
T
A
V
I
V
-
I
-
F
W
L
N
F
G
L
G
L
-
V
T
---------
A
T
I
L
A
V
I
A
Y
-
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
--
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
R
Y
A
S
A
A
R
A
Y
A
D
-
A
A
V
K
---
S
E
N
S
L
G
L
L
--
N
I
A
Q
A
L
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
--
L
T
V
G
D
L
V
F
V
N
T
Y
----
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
--
I
D
T
H
I
---
E
V
A
-
D
V
P
-
N
----
A
P
A
L
--
V
V
N
R
P
-
S
V
T
F
D
N
V
V
F
G
-
Y
D
R
D
--
R
E
--
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
-
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
DIAHVT
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
----
S
V
L
---
F
N
D
T
-
I
G
Y
N
I
A
Y
G
R
D
G
---
A
S
R
A
E
V
D
A
A
A
-------
K
---
G
A
A
I
A
D
F
I
A
R
L
P
Q
GYDTE
V
G
E
R
-----
G
L
K
--------------
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
--
V
A
--
S
H
R
T
T
I
S
I
--
A
H
R
L
S
-
T
I
A
D
S
D
T
I
-
L
V
L
D
Q
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
77.66
18%
-76
- C4 -
4Q9H
-
MDR1A_MOUSE
A:
[128-663]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
S
F
W
C
L
A
A
G
R
Q
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
---
E
I
G
W
F
D
V
----
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
--------------
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
-
I
G
F
T
R
G
W
K
L
T
L
-
V
-----------
I
L
A
I
S
P
V
L
-
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
--
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
-
L
G
I
K
---
K
A
I
T
A
N
I
S
--
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
--
Y
S
I
G
Q
V
L
T
V
F
F
S
----
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
--
I
D
N
K
P
---
S
I
D
-
S
F
S
-
K
S---
G
H
K
P
--
D
N
I
Q
G
-
N
L
E
F
K
N
I
H
F
S
-
Y
P
S
R
KE
V
Q
--
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
-
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
DIRTIN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
----
P
V
L
---
F
A
T
T
-
I
A
E
N
I
R
Y
G
R
E
D
---
V
T
M
D
E
I
E
K
A
V
-------
K
---
E
A
N
A
Y
D
F
I
M
K
L
P
H
QFD
T
L
V
G
E
R
-----
G
A
Q
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
--
A
R
--
E
G
R
T
T
I
V
I
--
A
H
R
L
S
-
T
V
R
N
A
D
V
I
-
A
G
F
D
G
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
76.94
16%
-81
- C4 -
4Q4H
-
Y288_THEMA
B:
[49-566]
-----------------------------------------------------------------------------------------------------------
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
-------------
R
R
F
-
D
-
L
L
P
R
Y
M
---
L
I
L
G
T
I
Y
----
A
----
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
---
P
V
G
F
F
D
----
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
--------------
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
------------
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
--
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
-
V
G
T
K
---
A
Q
I
F
S
G
V
L
--
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
--
I
T
V
G
T
I
A
T
F
I
G
Y
----
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
--
L
D
L
E
E
---
E
K
D
-
D
P
D
-
A
-----
V
E
L
--
R
E
V
R
G
-
E
I
E
F
K
N
V
W
F
S
-
Y
D
K
K
--
K
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
-
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
DIRKIK
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
----
T
I
L
---
F
S
T
T
-
V
K
E
N
L
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
-------
K
---
L
T
H
S
D
H
F
I
K
H
L
P
E
GYETV
L
T
D
N
-----
G
E
D
--------------
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
--
L
M
--
E
G
K
T
S
I
I
I
--
A
H
R
L
N
-
T
I
K
N
A
D
L
I
-
I
V
L
R
D
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
76.68
16%
-83
- C4 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
------
T
V
E
D
Y
E
G
D
N
I
D
-
S
N
---
G
E
---------------
I
K
I
T
R
D
E
V
V
N
K
V
S
I
P
Q
L
Y
R
Y
T
T
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
--
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
L
P
T
G
Q
-
N
-
Y
T
K
T
D
F
---
E
H
D
V
M
N
V
----
V
----
W
----
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
--
R
E
F
V
K
S
I
L
------------
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
--
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
-
Q
F
I
T
G
F
I
V
A
F
T
-
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
-
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
--
S
----
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
---
G
L
F
L
G
I
S
F
--
G
A
M
Q
A
S
N
F
I
S
F
A
-
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
--
L
N
F
G
D
M
L
T
T
F
S
S
----
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
--
L
D
R
K
P
---
V
I
D
-
S
S
S
-
K
----
A
G
R
K
--
D
M
K
I
K
G
D
I
T
V
E
N
V
H
F
T
-
Y
P
S
R
--
P
D
VP
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
-
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
----------
D
--------
V
----
R
D
I
---
N
L
E
F
-
L
R
K
N
V
A
V
V
S
Q
E
P
-
A
L
F
N
C
T
I
E
E
N
I
S
L
G
KEGI
T
---
R
E
E
M
V
A
A
C
K
M
A
N
A
-----
E
K
F
I
-----
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
--
A
A
--
K
G
R
T
T
I
I
I
--
A
H
R
L
S
-
T
I
R
N
A
D
L
I
-
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
-
A
-
L
M
A
-
Q
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
55
HHSearch
74.90
15%
-76
- C4 -
4Q9H
-
MDR1A_MOUSE
A:
[775-1246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
R
Q
---
D
V
S
W
F
D
D
P
--
K
N
T
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
--------------
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
-
I
S
L
I
Y
G
W
Q
L
T
L
------------
L
L
L
A
I
V
P
I
I
-
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
--
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
-
N
A
M
K
---
K
A
H
V
F
G
I
T
--
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
L
--
M
T
F
E
N
V
L
L
V
F
S
A
----
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
--
I
E
K
T
P
---
E
I
D
-
S
Y
S
-
T
Q---
G
L
K
P
--
N
M
L
E
G
-
N
V
Q
F
S
G
V
V
F
N
-
Y
P
T
R
PS
I
P
--
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
-
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
EIKQLN
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
----
P
I
L
---
F
D
C
S
-
I
A
E
N
I
A
Y
G
D
N
S
R
-
V
V
S
Y
E
E
I
V
R
A
A
-------
K
---
E
A
N
I
H
Q
F
I
D
S
L
P
D
KYNTR
V
G
D
K
-----
G
T
Q
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
--
A
R
--
E
G
R
T
C
I
V
I
--
A
H
R
L
S
-
T
I
Q
N
A
D
L
I
-
V
V
I
Q
N
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
73.32
17%
-75
- C4 -
4F4C
-
PGP1_CAEEL
A:
[158-679]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
---
E
I
S
W
F
D
T
----
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
--------------
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
-
V
A
F
T
H
S
W
Q
L
T
L
------------
V
M
L
A
V
T
P
I
Q
-
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
--
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
-
A
G
V
L
---
K
G
L
F
L
G
I
S
--
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
--
L
N
F
G
D
M
L
T
T
F
S
S
----
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
--
L
D
R
K
P
---
V
I
D
-
S
S
S
K
A
----
G
R
K
D
--
M
K
I
K
G
-
D
I
T
V
E
N
V
H
F
T
-
Y
P
S
R
PD
V
P
--
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
-
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
DVRDIN
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
----
P
A
L
---
F
N
C
T
-
I
E
E
N
I
S
L
G
K
E
G
---
I
T
R
E
E
M
V
A
A
C
-------
K
---
M
A
N
A
E
K
F
I
K
T
L
P
N
GYNTL
V
G
D
R
-----
G
T
Q
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
--
A
A
--
K
G
R
T
T
I
I
I
--
A
H
R
L
S
-
T
I
R
N
A
D
L
I
-
I
S
C
K
N
G
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
73.31
15%
-77
- C4 -
3B60
2
MSBA_SALTY
A:
[40-555]
--------------------------------------------------------------------------------------------------------------
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
-------------
T
D
R
-
S
-
V
L
L
W
M
P
---
L
V
V
I
G
L
M
----
I
L
R
G
I
T
----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
---
P
V
A
F
F
D
----
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
--------------
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
-
M
M
F
Y
Y
S
W
Q
L
S
I
------------
I
L
V
V
L
A
P
I
V
-
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
--
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
---
M
V
S
A
S
S
I
S
--
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
--
L
T
A
G
T
I
T
V
V
F
S
S
----
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
--
L
D
S
E
Q
---
E
K
D
-
E
G
K
-
R
------
V
I
--
D
R
A
T
G
-
D
L
E
F
R
N
V
T
F
T
-
Y
P
G
R
E-
V
P
--
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
-
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
DLREYT
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
----
V
H
L
---
F
N
D
T
-
V
A
N
N
I
A
Y
A
R
T
E
E
--
Y
S
R
E
Q
I
E
E
A
A
-------
R
---
M
A
Y
A
M
D
F
I
N
K
M
D
N
GLD
T
I
I
G
E
N
-----
G
V
L
--------------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
--
L
Q
--
K
N
R
T
S
L
V
I
--
A
H
R
L
S
-
T
I
E
Q
A
D
E
I
-
V
V
V
E
D
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
72.77
15%
-71
- C4 -
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------
W
Q
T
F
R
------
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
---------------------------------------
F
G
K
T
D
R
S
V
L
L
W
M
-----------------------
P
L
V
V
I
---
G
L
M
I
L
R
G
----
I
----
T
----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
-------
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
--
S
I
I
G
L
F
I
M
M
F
Y
Y
S
-------------------------
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
-
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
--
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
---
M
V
S
A
S
S
I
S
--
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
--
L
T
A
G
T
I
T
V
V
F
S
S
----
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
--
L
D
S
E
Q
---
E
K
D
-
E
G
K
-
R
----
V
I
D
R
--
A
T
G
D
---
L
E
F
R
N
V
T
F
T
Y
P
G
R
E
--
V
P
--
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
-
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
----------
D
L
R
E
Y
T
L
A
S
L
----
R
N
Q
---
V
A
L
V
-
S
Q
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
R
T
E
E
Y
-------
S
---
R
E
Q
I
E
E
A
A
R
M
A
Y
A
-----
M
D
F
I
-----
N
K
M
DNGLD
T
I
I
G
ENGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
--
L
Q
--
K
N
R
T
S
L
V
I
--
A
H
R
L
S
-
T
I
E
Q
A
D
E
I
-
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
-
E
-
L
L
A
-
Q
H
G
V
Y
A
Q
L
H
K
M
QFG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
72.71
17%
-78
- C4 -
3WMG
3
?
A:
[36-569]
--------------------------------------------------------------------------------------------------------
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
-----------
Q
I
E
-
G
-
E
T
W
K
Y
S
---
V
G
F
V
G
I
G
----
V
----
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
---
D
V
T
Y
F
D
----
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
--------------
K
L
G
-
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
-
V
A
F
I
F
A
P
A
L
T
G
-
V
-----------
L
I
A
L
S
P
L
V
-
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
--
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
-
L
G
R
R
---
R
Y
I
S
D
G
L
F
--
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
--
L
N
L
G
N
L
L
T
A
F
F
S
----
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
--
I
D
R
V
P
---
Q
Y
R
-
R
P
D
-
P
G
A
E
V
V
T
Q
P
--
L
V
L
K
Q
-
G
I
V
F
E
N
V
H
F
R
-
Y
P
T
R
MN
V
E
--
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
-
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
PAWNYD
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
----
P
V
L
---
F
S
G
T
-
I
R
D
N
I
L
Y
G
K
R
D
---
A
T
D
E
E
V
I
Q
A
L
-------
R
---
E
A
N
A
Y
S
F
V
M
A
L
P
D
GLD
T
E
V
G
E
R
-----
G
L
A
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
--
M
M
A
S
D
G
V
T
S
V
V
I
--
A
H
R
L
S
-
T
V
A
R
A
D
L
I
-
L
V
M
Q
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
71.80
17%
-80
- C4 -
4RY2
-
?
A:
[181-697]
-------------------------------------------------------------------------------------------------------------
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
-------------
E
K
L
-
N
-
D
L
H
I
I
S
---
A
G
F
A
V
I
F
----
L
----
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
---
P
M
N
F
F
N
S
----
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
--------------
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
-
L
L
Y
I
Q
N
S
S
L
F
F
------------
I
S
F
I
I
I
L
L
Y
-
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
--
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
-
S
S
F
K
---
E
G
M
L
Y
I
N
L
--
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
--
M
S
G
G
Q
L
L
A
F
N
A
L
----
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
--
L
E
L
A
T
---
E
K
E
-
L
------------------
G
-
D
I
E
F
R
N
V
D
F
R
-
Y
G
L
R
--
K
P
--
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
-
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
SIKNIS
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
----
V
F
I
---
F
S
G
T
-
V
K
E
N
L
C
L
G
N
E
N
---
V
D
M
D
E
I
I
K
A
A
-------
K
---
M
A
N
A
H
D
F
I
E
K
L
P
L
KYDTF
L
N
E
S
-----
G
A
N
--------------
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
--
L
E
--
D
D
V
T
V
I
I
I
--
A
H
R
L
S
-
T
I
V
N
C
D
K
I
-
Y
L
L
K
D
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
71.12
14%
-82
- C4 -
4Q4H
-
?
A:
[26-544]
------------------------------------------------------------------------------------------------------------
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
-------------
G
D
F
-
S
-
L
V
L
K
T
G
---
I
L
M
L
I
V
A
L
I
G
A
V
----
G
----
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
---
I
S
N
V
N
----
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
--------------
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
-
M
A
V
S
I
N
V
K
L
S
S
-
V
-----------
L
I
F
L
I
P
P
I
-
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
--
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
-
S
I
I
S
---
A
F
S
L
I
V
F
A
--
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
--
M
E
I
G
S
I
M
A
Y
T
N
Y
----
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
--
L
N
E
K
P
---
A
I
E
-
E
A
D
-
N
----
A
L
A
L
--
P
N
V
E
G
-
S
V
S
F
E
N
V
E
F
R
-
Y
F
E
N
T-
D
P
--
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
-
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
DVRTVK
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
----
T
V
L
---
F
S
G
T
-
I
K
E
N
L
K
W
G
R
E
D
---
A
T
D
D
E
I
V
E
A
A
-------
K
---
I
A
Q
I
H
D
F
I
I
S
L
P
E
GYDSR
V
E
R
G
-----
G
R
N
--------------
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
--
Y
T
--
K
G
C
T
T
F
I
I
--
T
Q
K
I
P
-
T
A
L
L
A
D
K
I
-
L
V
L
H
E
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
70.25
17%
25
- C- -
3B5X
-
MSBA_VIBCH
A:
[87-555]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
---
P
V
R
F
F
D
----
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
--------------
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
-
L
M
F
W
N
S
W
Q
L
S
L
------------
V
L
I
V
V
A
P
V
V
-
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
--
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
-
Q
T
M
K
---
L
V
S
A
Q
S
I
A
--
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
--
L
T
P
G
T
F
T
V
V
F
S
A
----
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
--
M
D
L
E
T
---
E
R
D
-
N
G
K
-
Y
------
E
A
--
E
R
V
N
G
-
E
V
D
V
K
D
V
T
F
T
-
Y
Q
G
K
E-
K
P
--
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
-
L
F
T
R
F
Y
D
V
D
---
S
G
S
I
C
L
D
G
H
DVRDYKLTNL
R
R
H
F
A
L
V
S
Q
N
----
V
H
L
---
F
N
D
T
-
I
A
N
N
I
A
Y
A
A
E
G
E
--
Y
T
R
E
Q
I
E
Q
A
A
-------
R
---
Q
A
H
A
M
E
F
I
E
N
M
P
Q
GLDTV
I
G
E
N
-----
G
T
S
--------------
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
--
L
Q
--
K
N
K
T
V
L
V
I
--
A
H
R
L
S
-
T
I
E
Q
A
D
E
I
-
L
V
V
D
E
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
70.07
16%
-80
- C4 -
4MYC
-
ATM1_YEAST
A:
[181-649]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
A
Q
N
A
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
L
---
D
L
G
W
H
L
S
----
R
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
--------------
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
G
A
S
F
A
A
------------
I
T
F
S
T
M
L
L
Y
-
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
--
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
-
S
Q
I
K
---
V
S
Q
S
L
A
F
L
--
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
G
C
T
G
V
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
----
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
--
R
K
N
E
V
---
K
I
K
-
N
A
E
-
R
P---
L
M
L
P
--
E
N
V
P
Y
-
D
I
T
F
E
N
V
T
F
G
-
Y
H
P
D
--
R
K
--
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
-
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
DIKEYD
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
----
T
P
L
---
F
N
D
T
-
I
W
E
N
V
K
F
G
R
I
D
---
A
T
D
E
E
V
I
T
V
V
-------
E
---
K
A
Q
L
A
P
L
I
K
K
L
P
Q
GFD
T
I
V
G
E
R
-----
G
L
M
--------------
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
--
N
F
TS
G
S
R
T
S
V
Y
I
--
A
H
R
L
R
-
T
I
A
D
A
D
K
I
-
I
V
L
D
N
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
69.02
15%
-74
- C4 -
4F4C
2
PGP1_CAEEL
A:
[821-1292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
---
H
I
G
F
F
D
S
P
--
Q
N
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
--------------
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
-
L
A
F
F
Y
G
W
Q
M
A
L
------------
L
I
I
A
I
L
P
I
V
-
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
--
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
-
E
A
I
K
---
E
A
F
I
Q
G
L
S
--
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
T
D
P
PT
M
Q
P
M
R
V
L
R
V
M
Y
A
----
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
--
L
R
K
I
S
---
K
I
D
-
S
L
S
-
L
----
A
G
E
K
--
K
K
L
Y
G
-
K
V
I
F
K
N
V
R
F
A
-
Y
P
E
R
PE
I
E
--
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
-
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
EIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
----
P
T
L
---
F
D
C
S
-
I
A
E
N
I
I
Y
G
L
D
P
S
-
S
V
T
M
A
Q
V
E
E
A
A
-------
R
---
L
A
N
I
H
N
F
I
A
E
L
P
E
GFETR
V
G
D
R
-----
G
T
Q
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
--
A
R
--
E
G
R
T
C
I
V
I
--
A
H
R
L
N
-
T
V
M
N
A
D
C
I
-
A
V
V
S
N
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
64.98
14%
-77
- C4 -
5C78
1
PGLK_CAMJE
A:
[101-559]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
G
R
K
H
A
I
A
Y
K
V
F
S
K
F
L
N
I
---
N
Y
E
K
F
T
----
Q
K
N
Q
S
E
I
L
K
S
I
T
G
E
V
Y
N
L
S
T
M
I
S
--------------
S
F
L
-
L
L
M
S
E
I
F
V
V
L
L
L
Y
A
-
L
M
L
L
I
N
Y
K
I
T
L
------------
F
L
S
I
F
M
V
L
N
A
F
I
L
V
K
I
L
S
P
I
I
K
K
A
G
L
R
R
E
E
A
M
K
N
F
F
E
I
L
N
T
N
L
N
N
F
--
K
F
I
K
L
K
T
K
E
D
G
V
L
S
L
F
K
A
Q
S
E
A
F
S
K
-
A
N
I
T
---
N
E
S
V
A
A
V
P
--
R
I
Y
---
L
E
G
I
G
F
C
V
L
V
F
I
V
V
F
L
V
L
K
N
E
--
S
D
I
S
G
I
L
S
T
I
S
I
F
V
L
A
L
Y
R
L
M
P
S
A
N
R
I
I
T
S
Y
H
D
L
L
Y
Y
H
S
S
L
N
I
I
Y
Q
N
--
L
R
Q
E
E
---
E
N
L
-
G
E
G
---------
K
--
L
S
F
N
Q
-
E
L
K
I
C
N
L
S
F
G
-
Y
E
G
K
--
K
Y
--
L
F
K
N
L
N
L
N
I
K
K
G
E
K
I
A
F
I
G
E
S
G
C
G
K
S
T
L
V
D
-
L
I
I
G
L
L
K
P
K
---
E
G
Q
I
L
I
D
K
Q
ELNASN
A
K
N
Y
R
Q
K
I
G
Y
I
P
Q
N
----
I
Y
L
---
F
N
D
S
-
I
A
K
N
I
T
F
G
D
A
----
V
D
E
E
K
L
N
K
V
I
-------
K
---
Q
A
N
L
E
H
F
I
K
N
L
P
Q
GVQTK
V
G
D
G
-----
G
S
N
--------------
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
Y
L
E
P
E
I
L
V
L
D
Q
A
T
S
A
L
D
T
Q
S
E
A
K
I
M
D
E
I
Y
K
--
I
S
--
K
D
K
T
M
I
I
I
--
A
H
R
L
S
-
T
I
T
Q
C
D
K
V
-
Y
R
L
E
H
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
64.31
17%
-69
- C4 -
4PL0
4
MCJD_ECOLX
A:
[181-555]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
F
N
T
R
L
T
G
S
L
A
S
L
R
K
H
S
M
D
I
T
L
N
S
Y
S
L
L
S
D
T
V
D
N
M
--
I
A
A
K
K
N
N
A
L
R
L
I
S
E
R
Y
E
D
A
L
T
Q
E
N
N
-
A
Q
K
K
---
Y
W
L
L
S
S
K
V
--
L
L
L
N
S
L
L
A
V
I
L
F
G
S
V
F
I
Y
N
I
L
G
V
L
N
G
V
--
V
S
I
G
H
F
I
M
I
T
S
Y
----
I
I
L
L
S
T
P
V
E
N
I
G
A
L
L
S
E
I
R
Q
S
M
S
S
L
A
G
F
I
Q
R
--
H
A
E
N
K
---
A
T
S
-
P
S
--
I
----
P
F
L
N
--
M
E
R
K
L
-
N
L
S
I
R
E
L
S
F
S
-
Y
S
D
D
--
K
K
--
I
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
-
I
I
S
G
Y
Y
K
N
Y
---
F
G
D
I
Y
L
N
D
I
SLRNIS
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
----
D
Y
I
---
F
M
D
T
-
L
R
F
N
L
R
L
A
N
Y
D
---
A
S
E
N
E
I
F
K
V
L
-------
K
---
L
A
N
L
S
-
V
V
N
N
E
P
V
S
LD
T
H
L
I
N
R
-----
G
N
N
--------------
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
--
H
F
--
P
D
A
L
I
I
N
I
--
S
H
R
I
N
-
L
L
E
C
S
D
C
V
-
Y
V
L
N
E
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
64.30
16%
-80
* C5 *
1YQT
4
?
A:
[24-538]
--------------------
E
E
D
C
V
H
R
YGVN
A
F
V
L
Y
R
L
P
V
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
G
D
N
D
S
W
D
G
V
I
R
A
F
R
G
N
E
-----------------------------------
L
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
-------------------------------------------------------------------------------------------
V
V
K
P
--------------
Q
Y
V
D
L
I
--
P
K
A
V
K
G
K
V
I
E
L
L
K
K
A
D
E
T
G
-
K
L
E
E
V
V
K
A
L
E
L
-
E
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
-
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
--
S
E
E
G
--------------------------------
K
S
V
L
V
--
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
-------------------------
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
--
R
F
R
P
Y
---
E
I
K
F
T
K
T
-
G
----
E
R
V
E
--
I
E
R
E
T
-
L
V
T
Y
P
R
L
V
K
D
-
Y
--
G
--
S
F
--
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
---
G
K
I
E
W
----------------
D
L
T
V
A
Y
K
P
----
Q
Y
I
K
A
D
Y
E
G
T
-
V
Y
E
L
L
S
K
I
D
A
S
K
-
L
N
S
N
F
Y
K
T
E
L
L
-------
K
---
P
L
G
I
I
D
L
Y
D
R
-----------
E
-----
V
N
E
--------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
--
N
E
K
T
A
L
V
V
--
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
E
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
G
I
T
F
R
R
D
PDTG
R
P
R
A
N
K
EGS
V
K
D
R
E
Q
K
E
K
GEYYYIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------