@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1821: (2016-05-05 )
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSRSLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNPDVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTRDVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIRESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTLSALSLPGVFR
Atome Classification :
(22 SA)
.........10........20........30........40........50-........60........70........80...-.....---90....------.---...100.......110.......120.......130.......140.......150.......160.......170.......180.......190------------.......--------------------------------------------------200--------------------------........210.......220.......230......---.240.......250.......260......-.270..--.-.....280....--------...290-----.........300.......310...-------....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490..----------------------------------------------------------------------------.....500.......510.......520-........530.......540----------------------------------.-------------------------------------.-----------------------------------------------------------..----------------------..--..550.......560.......570.......580.......590.--------...--------...600.....----..610.......620.......630.......640.......650.......660----------------....---------------------------------------------------..-------------------------------------------------------------.---..--670.------.--------.----------------------------..------------.--------.-------------------------------------------------------680----------------------------------------------..---------------..--------------------------...690...-......-----------------------700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNVHGCPR
I
A
A
C
RCTDTHPRGR
P
A
F
A
Y
R
W
FVPKTTRAQPG
R
L
S
S
R
F
W
R
L
LG-ASTEKNRSRS
L
A
D
V
TASAEYD
K
E
AADL
S
D
E
K
L
R
-
K
A
AGL---L
N
L
D
D
L
------A---ESAD
I
P
Q
F
L
A
I
A
R
E
A
A
E
RRTGLR
P
F
D
V
Q
L
L
G
A
L
R
M
L
A
G
D
V
I
E
MATGEG
K
T
L
A
G
A
I
A
AA
G
Y
ALAG
R
H
V
H
V
V
T
I
N
D
Y
L
A
RR
D
A
E
W
M
G
P
L
L
D
A
MG
L
T
V
G
------------
W
I
TADST--------------------------------------------------
P
D
---------------------------
E
RRTAYDRDVT
Y
A
S
V
N
E
I
G
F
D
V
L
R
D
Q
L
V
T
D
V
N
D
LVSP---NP
D
V
A
L
IDEAD
S
V
L
V
D
EA
L
V
P
L
V
LAGTTHR-ET
P
-
R
L
--
E
-
I
I
R
L
V
A
E
L
VGDK--------D
A
D
E-------YFATDSDNR
N
V
H
L
T
E
H
G
A
R
K
V
E
K
A
L-------GGIDLYSEEHVG
T
T
L
T
E
V
N
V
A
L
H
A
H
V
L
L
QRD
V
H
Y
I
VRDD
A
V
H
L
I
NASRG
R
I
A
Q
L
Q
RWP
D
G
L
Q
A
A
V
E
A
KEGIETTETG
E
V
L
D
T
I
T
V
Q
A
L
I
N
R
Y
A
T
V
CGMTG
T
A
L
A
A
G
E
Q
L
R
Q
F
Y
Q
LGVSPIPPNKPNIREDEA
D
R
V
Y
I
T
TAAKND
G
I
V
E
H
I
T
E
V
H
QRGQ
P
V
L
V
GTRDVA
E
S
E
E
L
H
E
R
L
V
R----------------------------------------------------------------------------RGV
P
A
V
V
L
NAKN
D
A
E
E
A
R
V
I
A
EAGKY
G
--
A
V
T
V
S
T
Q
MAGRG
T
D
I
R
LGGS-----------------------------------D-------------------------------------E-----------------------------------------------------------
A
D
----------------------
H
D
--
R
V
A
E
LG
G
L
H
V
VGTGR
H
H
T
E
R
L
D
N
Q
L
RGRAGRQGDPGS
S
V
F
FSSWED--------D
V
V
--------
A
ANLDHNKLPM----ATDEN
G
R
I
VSPRT
G
S
L
L
D
H
A
Q
R
V
AEG
R
L
L
D
V
HANT
W
R
Y
N
Q
L
I
A
Q
Q
R
A
I
I
V
E
RR------------------
N
T
L
L
---------------------------------------------------
R
T
-------------------------------------------------------------
V
---
T
A
--
R
E
E
L
------
A
--------
E
----------------------------
L
A
------------
P
--------
K
-------------------------------------------------------
R
Y
E
----------------------------------------------
E
L
---------------
S
D
--------------------------
K
V
S
E
--
E
R
L
-
E
T
I
C
R
Q
-----------------------
I
M
L
Y
HLDRG
W
A
D
H
L
A
Y
L
A
D
I
R
E
S
I
H
L
RALGRQN
P
L
D
E
F
H
R
M
A
V
D
A
F
A
S
L
A
A
D
A
I
E
A
A
Q
Q
T
F
E
T
ANVLDHEPGL
D
L
S
K
LARPTS
T
W
T
Y
M
VNDNPLSDDT
L
S
A
LSLPGVFR
41
HHSearch
81.77
37%
-69
- C6 -
1TF5
-
SECA_BACSU
A:
[14-780]
--------------------------------------------------------
R
T
L
N
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
-
H
K
T
I
E
---
F
K
E
R
L
E
K
GA---
T
---
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
-
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
------------
K
-------
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
-
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
------------------
F
E
V
I
---------------------------------------------------
D
S
-------------------------------------------------------------
E
---
N
L
--
R
E
I
V
------
E
N
M
I
K
S
S
L
E
R
----------------------------
A
I
A
A
Y
T
--------
P
REELP---
E
-------------------------------------------------------
E
W
K
LDGL
V
D
L
I
N
T
TYLDEGALEKSDIFGKE
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
--
E
K
---------------
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
-------------------------------------------
39
HHSearch
81.52
36%
-68
- C6 -
1NKT
2
SECA1_MYCTU
A:
[35-865]
------------------------------------------------
L
L
R
-
L
G
E
G
R
M
V
K
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
-
A
K
T
D
E
---
F
K
R
R
L
A
DQK
N
P
E
T
---
L
D
D
L
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
------------
V
I
L
A
T
M
T
--------------------------------------------------
P
D
---------------------------
E
R
R
V
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
A
S
N
W
-
Y
T
--
E
-
F
A
R
L
A
P
L
M
E
K
D
------------
V
-------
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
-------
G
I
D
N
L
Y
E
A
A
N
-
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
--
E
Q
E
A
T
I
I
A
V
A
G
R
RG
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
N
-----------------------------------
V
D
F
L
T
D
Q
R
L
R
E
R
GLDPVET
P
E
E
Y
E
A
A
W
H
S
E
L
P
I
V
K
E
E
A
S
-----------------------------------------------------------
K
E
----------------------
A
K
--
E
V
I
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
--------
E
L
M
--------
R
R
F
N
G
A
A
L
E
T
L
L
T
R
L
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
A
E
R
------------------
R
R
I
L
---------------------------------------------------
E
G
-------------------------------------------------------------
E
---
N
L
--
K
D
Q
A
------
L
D
M
V
R
D
V
I
T
A
----------------------------
Y
V
------------
D
G
A
T
GEGYA
E
-------------------------------------------------------
D
W
D
L
D
A
L
W
T
A
L
K
T
L
YPVGITADSLT-------------------------
L
L
E
A
L
L
K
D
A
E
R
A
Y
A
A
R
E
A
E
L
E
E
----------------------
I
A
G
E
--
G
A
M
-
R
Q
L
E
R
N
-----------------------
V
L
L
N
V
I
D
R
K
W
R
E
H
L
Y
E
M
D
Y
L
K
E
G
I
G
L
R
A
M
A
Q
R
D
P
L
V
E
Y
Q
R
E
G
Y
D
M
F
M
A
M
L
D
G
M
K
E
E
S
V
G
F
L
F
N
V
T
V
-------------------------------------------
42
HHSearch
80.14
37%
-69
- C6 -
4YS0
2
SECA_THEMA
A:
[9-819]
--------------------------------------------------------
R
I
L
K
K
Y
A
K
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
-
R
L
S
M
V
---
L
K
E
K
V
N
S
F
E
---
D
---
A
D
E
H
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
------------
V
I
N
S
L
G
K
S
Y
E
V
V
W
KN
P
D
L
A
R
K
A
I
E
E
NWSVWPDGFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
---------------------------
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
E
S
P
S
V
-
Y
R
--
R
-
F
A
Q
I
A
K
K
F
V
K
D
------------
K
-------
D
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
E
N
L
Y
D
P
G
N
-
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
K
K
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
--
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
--------
D
L
L
--------
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
------------------
D
Q
I
L
---------------------------------------------------
L
E
-------------------------------------------------------------
K
---
D
Y
--
D
E
Y
L
------
K
--------
D
----------------------------
I
F
------------
E
--------
D
V
V
S
T
R
V
E
E
FCSGKNWD
I
E
S
L
K
N
S
L
SFFPAGLFDLDEKQFSS
S
E
E
L
H
D
Y
L
F
N
R
L
W
E
E
Y
Q
----------------------------------------------
R
K
---------------
K
Q
--------------------------
E
I
G
---
E
D
Y
-
R
K
V
I
R
F
-----------------------
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
A
V
Q
L
R
S
----
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
N
D
T
I
A
N
Y
V
L
R
V
L
E
H
------------------------------------------
38
HHSearch
79.40
38%
-63
- C6 -
2IPC
-
SECA_THET8
A:
[19-939]
------------------------------------------------------------
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
L
P
D
--
L
A
-
A
A
Y
R
E
---
L
K
E
K
H
E
K
GA---
S
---
L
D
E
L
L
P
M
A
F
A
L
T
R
E
S
A
K
R
Y
L
G
M
R
H
F
D
V
Q
L
I
G
G
A
V
L
H
E
G
K
I
A
E
M
K
T
G
E
G
K
T
L
V
A
T
L
A
V
A
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
R
R
D
A
E
W
M
G
P
V
Y
R
G
L
G
L
S
V
G
------------
V
I
Q
H
A
S
T
--------------------------------------------------
P
A
---------------------------
E
R
R
K
A
Y
L
A
D
V
T
Y
V
T
N
S
E
L
G
F
D
Y
L
R
D
N
M
A
I
S
P
D
Q
L
V
L
R
HDH
P
L
H
Y
A
I
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
K
A
T
D
L
-
Y
Y
--
K
-
M
A
E
I
A
K
K
L
E
R
G
L
P
A
EPGVRK
E
P
T
G
-------
D
Y
T
V
E
E
K
N
R
S
V
H
L
T
L
Q
G
I
A
K
A
E
K
L
L
-------
G
I
E
G
L
F
S
P
E
N
-
M
E
L
A
H
M
L
I
Q
A
I
R
A
K
E
L
Y
H
R
D
R
D
Y
I
V
Q
D
G
Q
V
I
I
V
D
E
F
T
G
R
L
M
P
G
R
R
Y
G
E
G
L
H
Q
A
I
E
A
K
E
G
V
R
I
E
R
E
N
Q
T
L
A
T
I
T
Y
Q
N
F
F
R
L
Y
E
K
R
A
G
M
T
G
T
A
K
T
E
E
K
E
F
Q
E
I
Y
G
M
D
V
V
V
V
P
T
N
R
P
V
I
R
K
D
F
P
D
V
V
Y
R
T
E
K
G
K
F
Y
A
V
V
E
E
I
A
E
K
Y
E
R
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
R
L
S
Q
M
L
K
E
PRLY
L
P
R
L
E
M
R
L
E
L
F
K
K
A
S
QKQQG
P
E
W
E
R
L
R
KLLERPAQLKDEDLAPFEGLIPPKG
N
L
R
T
A
W
E
G
L
K
R
A
V
H
T
L
A
V
L
R
Q
G
I
P
H
Q
V
L
N
A
K
H
H
A
R
E
A
E
I
V
A
Q
A
G
R
S
K
--
T
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
G
N
-----------------------------------
P
-------------------------------------
E
Y
L
A
A
A
L
L
E
K
EGFDRYEWK
V
E
L
F
I
K
K
M
V
A
GK
E
E
E
A
R
A
L
A
Q
E
L
GIR
E
E
L
L
E
R
I
R
E
I
R
E
E
C
K
Q
D
----------------------
E
E
--
R
V
R
A
L
G
G
L
F
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
G
S
R
F
Y
V
S
F
D
D
--------
D
L
M
--------
R
L
F
A
S
D
R
V
I
A
M
L
D
R
M
G
F
D
D
S
E
P
I
E
H
P
M
V
T
R
S
I
E
R
A
Q
K
R
V
E
D
R
N
F
A
I
R
K
Q
L
L
Q
F
D
D
V
L
S
R
Q
R
E
V
I
Y
A
Q
R
------------------
R
L
I
L
---------------------------------------------------
L
G
-------------------------------------------------------------
K
---
D
E
E
V
K
E
A
A
------
I
--------
G
----------------------------
M
V
E
E
T
V
A
S
L
A
E
NFL
N
PEVHP---
E
-------------------------------------------------------
D
W
D
L
E
G
L
K
A
T
L
L
D
T
A
P
Q
L
Q
D
F
P
F
A
ELRALKA
E
E
A
V
E
R
L
V
E
A
A
L
K
A
Y
E
--
A
R
---------------
E
A
--------------------------
E
L
S
P
--
P
L
M
-
R
A
V
E
R
F
-----------------------
V
I
L
N
V
V
D
N
A
W
K
E
H
L
H
N
L
D
V
L
R
Q
G
I
F
L
R
G
Y
G
Q
K
D
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
L
K
V
E
------------------------------------------
7
PsiBlast_PDB
79.05
36%
-74
- C6 -
1TF5
-
SECA_BACSU
A:
[50-763]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
E
L
------
P
--------
E
EWKLDGL
V
D
L
I
N
T
TYLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
27
Fugue
78.46
35%
-60
- C6 -
1M6N
7
SECA_BACSU
A:
[1-802]
------------------------------------------
M
L
G
I
L
N
K
M
F
-
D
P
T
K
R
T
L
N
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
-
H
K
T
I
E
---
F
K
E
R
L
E
------
K
GAT
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
----
T
--
K
-
L
Y
V
Q
A
N
A
F
V
R
T
L
--------
K
A
E
K
-------
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
-
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
R
R
FG----
A
E
R
T
M
A
M
L
D
R
F
----
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
------------------
F
E
V
I
---------------------------------------------------
D
S
ENL
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PREELPEEWK
L
D
G
L
V
D
L
I
N
T
T
YLDEGALEKSDIFGKE
P
D
---
E
M
--
L
E
L
I
------
M
--------
D
----------------------------
R
I
------------
I
--------
T
-------------------------------------------------------
K
Y
N
----------------------------------------------
E
K
---------------
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
E
N
N
L
E
R
------------------
E
E
V
V
Q
G
Q
T
T
A
H
Q
P
Q
E
G
---
6
PsiBlast_PDB
77.30
36%
-71
- C6 -
1TF2
2
SECA_BACSU
A:
[53-766]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
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A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
-----------------
E
EWKLDG
L
V
D
L
I
N
T
T
YLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
21
PsiBlast_CBE
77.16
36%
-69
- C6 -
3JV2
3
SECA_BACSU
B:
[53-766]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
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L
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A
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A
K
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G
L
E
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Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
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E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
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N
R
P
V
V
R
D
D
R
P
D
L
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Y
R
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G
K
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K
A
V
A
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D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
------------------EWKLDG
L
V
D
L
I
N
T
T
YLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
8
PsiBlast_PDB
76.61
36%
-69
- C6 -
3JV2
3
SECA_BACSU
A:
[53-766]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
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K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
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V
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D
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G
R
L
M
K
G
R
R
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L
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A
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A
K
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L
E
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Q
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M
T
L
A
T
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Q
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M
Y
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K
L
A
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R
N
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N
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V
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D
D
R
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Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
----------------------WKLD
G
L
V
D
L
I
N
T
T
YLDEGALEKSDIFG-
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
24
PsiBlast_CBE
76.52
38%
-68
- C6 -
1NKT
2
SECA1_MYCTU
B:
[24-708]
------------------
P
R
G
S
M
A
D
----
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
Q
K
N
P
-
E
--------
T
L
D
D
L
--------------
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
------------
V
I
L
A
T
M
T
--------------------------------------------------
P
D
---------------------------
E
R
R
V
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
-
A
S
N
-
W
Y
--
T
-
E
F
A
R
L
A
P
L
M
-----------
E
K
D
V
-------
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
-------
G
I
D
N
L
Y
-
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
--
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
N
VDFLTDQRLRERGLDPVETPEEYEAAWHSELPIVK
E
-------------------------------------
E
-----------------------------------------------------------
A
S
----------------------
K
E
AK
E
V
I
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
--------
E
L
M
RRFN----
G
A
A
L
E
T
L
L
T
R
L
----
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
A
E
R
------------------
R
R
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.75
36%
-64
- C6 -
2VDA
-
SECA_ECOLI
A:
[20-814]
----------------------------------------------------------
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
--
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
V
------
L
---
E
N
L
-
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
------------
I
N
L
P
G
M
P
--------------------------------------------------
A
P
---------------------------
A
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
-
S
S
E
-
M
Y
--
K
R
V
N
K
I
I
P
H
L
I
R
Q
E
--------
K
E
D
S
ETFQGEG
H
F
S
V
D
E
K
S
R
Q
V
N
L
T
E
R
G
L
V
L
I
E
E
L
L
VKEGIMD
E
G
E
S
L
Y
S
P
A
N
I
-
M
L
M
H
H
V
T
A
A
L
R
A
H
A
L
F
T
R
D
V
D
Y
I
V
K
D
G
E
V
I
I
V
D
E
H
T
G
R
T
M
Q
G
R
R
W
S
D
G
L
H
Q
A
V
E
A
K
E
G
V
Q
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
S
-----------------------------------
W
-------------------------------------
Q
-----------------------------------------------------------
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
--
A
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
ALMRIFAS
D
R
V
--------
S
G
M
M
--
R
K
L
G
M
----
K
P
G
E
A
--
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
------------------
N
E
L
L
D
V
SDV
S
---------------------------------------------
E
T
-------------------------------------------------------------
I
---
N
S
I
-
R
E
D
V
F
K
A
T
I
D
A
--------
Y
----------------------------
I
P
------------
P
--------
Q
-------------------------------------------------------
S
L
E
----------------------------------------------
E
M
---------------
W
D
I
P
G
L
Q
E
R
L
K
N
DFDLDLP
I
A
E
W
L
D
K
EP
E
L
H
E
--
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
E
E
V
V
G
A
E
M
M
R
H
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
------------------------------------------------------------
3
PsiBlast_PDB
75.56
36%
-67
- C6 -
1M74
7
SECA_BACSU
A:
[50-763]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
R
R
F
GA
E
R
T
M
A
M
L
D
R
----
F
----
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
E
L
------
P
--------
E
EWKLD
G
L
V
D
L
I
N
T
TYLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
2
PsiBlast_PDB
75.56
36%
-68
- C6 -
1M6N
7
SECA_BACSU
A:
[50-763]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
R
R
FGA
E
R
T
M
A
M
L
D
R
----
F
----
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
E
L
------
P
--------
E
EWK
L
D
G
L
V
D
L
I
N
T
T
YLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
17
PsiBlast_PDB
75.41
35%
-72
- C6 -
4YS0
2
SECA_THEMA
A:
[61-801]
----------------------------------------------------------------------------------------------------------------------
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
I
N
S
LG
K
S
Y
E
V
V
W
K
N
P
D
L
A
R
K
A
I
E
E
NWSVW---------------------------------------
P
D
GFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
-
K
-
E
S
P
-
S
V
Y
R
R
-
F
A
Q
I
A
K
K
F
V
K
D
K
--------
D
-----------
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
-
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
G
E
V
I
I
V
D
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F
T
G
R
L
L
P
G
R
R
Y
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G
G
L
H
Q
A
I
E
A
K
E
G
V
P
I
K
E
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Y
A
T
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T
F
Q
N
Y
F
R
M
Y
E
K
L
A
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M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
K
K
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
--
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
--------
D
L
L
R
I
FG----
S
E
Q
I
G
K
V
M
N
I
L
----
K
I
E
E
G
Q
P
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
------------------
D
Q
I
L
L
EKDY
D
E
Y
L
K
D
I
F
E
D
V
V
S
T
R
V
E
E
FCSGKNWD
I
E
S
L
K
N
S
L
SFFPAGLFDLDE
K
Q
-------------------------------------------------------------
F
---
S
S
--
S
E
E
L
------
H
--------
D
Y
---------------------------
L
F
------------
N
--------
R
-------------------------------------------------------
L
W
E
----------------------------------------------
E
Y
---------------
Q
R
--------------------------
K
K
Q
E
I
G
E
D
Y
-
R
K
V
I
R
F
-----------------------
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
A
V
Q
L
R
S
----
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
------------------------------------------------------------
19
PsiBlast_PDB
75.26
38%
-67
- C6 -
1NKT
2
SECA1_MYCTU
A:
[24-708]
------------------
P
R
G
S
M
A
D
----
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
Q
K
N
P
-
E
--------
T
L
D
D
L
--------------
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
------------
V
I
L
A
T
M
T
--------------------------------------------------
P
D
---------------------------
E
R
R
V
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
-
A
S
N
-
W
Y
--
T
-
E
F
A
R
L
A
P
L
M
-----------
E
K
D
V
-------
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
-------
G
I
D
N
L
Y
-
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
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D
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F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
--
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
N
V
D
F
L
T
D
Q
R
L
R
E
R
GLDPVET
P
E
E
Y
E
A
A
W
H
S
E
L
P
I
V
K
E
-------------------------------------
E
-----------------------------------------------------------
A
S
----------------------
K
E
A
K
E
V
I
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
--------
E
L
M
R
R
FN----
G
A
A
L
E
T
L
L
T
R
L
----
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
A
E
R
------------------
R
R
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.10
36%
-67
- C6 -
3IQY
4
SECA_BACSU
A:
[50-763]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
Q
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
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V
D
S
F
T
G
R
L
M
K
G
R
R
Y
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G
L
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A
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A
K
E
G
L
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I
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N
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M
T
L
A
T
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F
Q
N
Y
F
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M
Y
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K
L
A
G
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T
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T
A
K
T
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E
E
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F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
K
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
E
L
------
P
--------
E
EWK
L
D
G
L
V
D
L
I
N
T
T
YLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
18
PsiBlast_PDB
75.02
35%
-67
- C6 -
3JUX
2
SECA_THEMA
A:
[61-801]
----------------------------------------------------------------------------------------------------------------------
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
I
N
S
LG
K
S
Y
E
V
V
W
K
N
P
D
L
A
R
K
A
I
E
E
NWSVW---------------------------------------
P
D
GFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
-
K
-
E
S
P
-
S
V
Y
R
R
-
F
A
Q
I
A
K
K
F
V
K
D
K
--------
D
-----------
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
-
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
G
E
V
I
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D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
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A
I
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A
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P
I
K
E
E
S
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A
T
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F
Q
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Y
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M
Y
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L
A
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T
G
T
A
K
T
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E
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E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
K
K
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
--
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
--------
D
L
L
R
I
FG----
S
E
Q
I
G
K
V
M
N
I
L
----
K
I
E
E
G
Q
P
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
------------------
D
Q
I
L
L
EKDY
D
E
Y
L
K
D
I
F
E
D
V
V
S
T
R
V
E
E
FCSGKNWDI
E
S
L
K
N
S
L
SFFPAGLFDLDE
K
Q
-------------------------------------------------------------
F
---
S
S
--
S
E
E
L
------
H
--------
D
Y
---------------------------
L
F
------------
N
--------
R
-------------------------------------------------------
L
W
E
----------------------------------------------
E
Y
---------------
Q
R
--------------------------
K
K
Q
E
IG
E
D
Y
-
R
K
V
I
R
F
-----------------------
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
A
V
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L
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Y
G
Q
K
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
------------------------------------------------------------
40
HHSearch
74.13
38%
-65
- C6 -
2FSF
-
SECA_ECOLI
A:
[16-832]
--------------------------------------------------------
R
T
L
R
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
-
G
K
T
A
E
---
F
R
A
R
L
E
K
GE---
V
---
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
------------
I
N
L
P
G
M
P
--------------------------------------------------
A
P
---------------------------
A
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
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M
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G
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A
D
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A
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S
I
Y
K
L
D
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V
V
V
P
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N
R
P
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K
D
L
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D
L
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Y
M
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E
A
E
K
I
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A
I
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D
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K
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P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
S
-----------------------------------
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
---------------
Q
-----------------------------------------------------------
V
R
----------------------
H
D
--
A
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
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S
R
R
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D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
--------
A
L
M
--------
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
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S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
------------------
N
E
L
L
---------------------------------------------------
D
V
-------------------------------------------------------------
S
---
D
V
--
S
E
T
I
------
N
--------
S
----------------------------
I
R
E
D
V
F
K
A
T
I
D
A
Y
I
P
PQSLE---
E
-------------------------------------------------------
M
W
D
I
P
G
L
Q
E
R
L
K
N
DFDLDLP
I
A
E
W
L
D
K
E
PELH
E
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
---------------
E
E
--------------------------
V
V
G
A
--
E
M
M
-
R
H
F
E
K
G
-----------------------
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
------------------------------------------
9
PsiBlast_PDB
73.75
36%
-67
- C6 -
3IQM
10
SECA_BACSU
A:
[50-763]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
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Q
L
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G
G
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A
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N
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A
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M
K
T
G
E
G
K
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L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
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V
D
S
I
L
I
D
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A
R
T
P
L
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S
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Q
A
A
K
-
S
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K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
E
K
--------
D
-----------
Y
T
Y
D
I
K
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K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
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V
V
I
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G
R
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L
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G
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V
V
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A
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Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
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R
H
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R
R
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L
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G
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G
R
Q
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T
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F
Y
L
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M
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D
--------
E
L
M
R
R
F
GA
E
R
T
M
A
M
L
D
R
----
F
----
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
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S
Q
K
R
V
E
G
N
N
F
D
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Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
SENL
R
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
E
L
------
P
--------
E
EWK
L
D
G
L
V
D
L
I
N
T
T
YLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
5
PsiBlast_PDB
73.62
36%
-64
- C6 -
2IBM
1
SECA_BACSU
A:
[50-763]
---------------------------------------------------------------------------------
E
R
L
E
-
K
G
A
------
T
T
D
D
L
------
L
---
V
E
A
-----
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
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Q
M
G
K
I
F
E
F
L
G
L
T
V
G
------------
L
N
L
N
S
M
S
--------------------------------------------------
K
D
---------------------------
E
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
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D
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V
D
S
I
L
I
D
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A
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T
P
L
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G
Q
A
A
K
-
S
T
K
L
Y
V
--
Q
-
A
N
A
F
V
R
T
L
K
A
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--------
D
-----------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
D
N
L
F
D
V
K
H
V
A
L
N
-
H
H
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N
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A
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A
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V
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L
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A
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V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
G
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
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G
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G
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Q
G
D
P
G
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T
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F
Y
L
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M
E
D
--------
E
L
M
--------
R
R
F
G
A
E
R
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A
M
LDRF
G
M
D
D
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A
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S
Q
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N
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F
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L
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D
D
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Y
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E
V
I
D
SENLR
E
I
V
E
N
M
I
K
S
S
L
E
---------------------------------------------------
R
A
-------------------------------------------------------------
I
A
A
Y
T
P
--
R
E
E
L
------
P
--------
E
EWKL
D
G
L
V
D
L
I
N
TTYLDEGALEKSDIFG
K
E
------------
P
--------
D
-------------------------------------------------------
E
M
L
----------------------------------------------
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
---
E
E
--------------------------
Q
F
G
K
--
E
Q
M
-
R
E
F
E
K
V
-----------------------
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
------------------------------------------------------------
26
PsiBlast_CBE
43.41
39%
-39
- C6 -
3BXZ
3
SECA_ECOLI
A:
[192-454]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
A
F
S
P
E
E
R
V
Q
R
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
-------------------
I
D
E
A
R
T
P
L
I
I
------
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
S
-----------------------------------
W
-------------------------------------
Q
-----------------------------------------------------------
A
E
V
A
A
LENPTAE
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
--
A
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
43.06
39%
-43
- C6 -
3BXZ
3
SECA_ECOLI
B:
[192-454]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
A
F
S
P
E
E
R
V
Q
R
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
-------------------
I
D
E
A
R
T
P
L
I
I
------
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
--
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
G
S
-----------------------------------
W
-------------------------------------
Q
-----------------------------------------------------------
A
E
VAALENPTAEQIEKIKADWQVR
H
D
--
A
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------