@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1859: (2016-05-05 )
MSKLQLRAVVADRRLDVEFSVSAGEVLAVLGPNGAGKSTALHVIAGLLRPDAGLVRLGDRVLTDTEAGVNVATHDRRVGLLLQDPLLFPHLSVAKNVAFGPQCRRGMFGSGRARTRASALRWLREVNAEQFADRKPRQLSGGQAQRVAIARALAAEPDVLLLDEPLTGLDVAAAAGIRSVLRSVVARSGCAVVLTTHDLLDVFTLADRVLVLESGTIAEIGPVADVLTAPRSRFGARIAGVNLVNGTIGPDGSLRTQSGAHWYGTPVQDLPTGHEAIAVFPPTAVAVYPEPPHGSPRNIVGLTVAEVDTRGPTVLVRGHDQPGGAPGLAACITVDAATELRVAPGSRVWFSVKAQEVALHPAPHQHASS
Atome Classification :
(47 SA)
-.......-----..-10...-------.....20........30........40........50........60........70......-..80........90........100--........110.......120--........130........140.......150.......160.......170.......180.......190.......200.......210.......220.......230......-..240---....-...--.250-.--.--.-.-.---..260....----.---.---.-270.......280......-.290..--.....300.......310.......320.......330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MS
K
L
Q
L
R
-----
A
V
-
V
AD
R
R
-------
L
D
V
E
F
SVSA
G
E
V
L
A
V
LGPNGAG
K
S
T
A
L
H
V
I
A
G
L
LRPDA
G
L
V
R
LG
D
R
V
LTDTEAG
V
N
V
ATHD
R
R
-
V
G
L
L
LQDPLLF
P
H
L
S
V
A
KNVAF
G
P
---
Q
CRRGMFGSGR
A
R
T
R
A
S
A
L
R
---
W
L
R
EV
N
A
E
Q
-
F
ADRKPRQLSGG
Q
A
Q
R
V
A
I
A
R
A
LAAEP
D
V
L
L
LDEPLT
G
L
D
V
A
A
A
A
G
I
R
S
V
L
R
S
V
V
ARSG
C
A
V
V
L
T
T
H
D
L
L
D
V
F
T
LA
D
R
V
L
V
LESGTIAEIG
P
V
A
D
V
L
TA
P
-
R
S
RFG
A
R
-
I
A
G
-
V
---
N
L
VN-GTI--GPDG-S--L--R-T-Q---SGAHWYGT
P
----
V
---
Q
---D-LPTGH
E
A
I
A
V
FPP
T
A
V
A
VY-PEPPHG--SPR
N
I
V
G
L
T
V
A
E
VDTRG
P
T
V
L
V
R
GHDQPGGAPG
L
A
A
C
I
T
VDAA
T
E
L
R
VAPG
S
R
V
W
F
S
V
K
A
Q
E
V
A
LHPAPHQHASS
112
HHSearch
88.33
28%
-107
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-361]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
L
A
G
----
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
-
S
P
K
M
N
F
L
P
-
V
K
V
--
T
A
T
A
-
I
D
Q
V
Q
V
E
-
L
-
P
MPN
R
Q
Q
V
W
L
P
V
E
----
S
---
R
---
D
-
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
-
D
I
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
---
S
I
R
--
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
---
114
HHSearch
88.32
33%
-108
- C1 -
1Z47
1
?
A:
[24-354]
-------------
Y
P
G
G
A
R
S
V
-------
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
K
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
---
R
E
K
R
----
V
P
K
D
E
M
D
A
R
V
R
E
---
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
-
G
T
L
F
V
A
S
-
F
I
G
-
E
S
--
N
V
W
T
-
R
A
V
--
Q
N
G
R
----
I
--
E
-
V
-
A
----
G
A
A
L
P
V
D
---------
P
---
A
-
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
-
P
A
S
E
-------
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
--
D
G
E
V
W
E
V
H
V
P
--
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
--
T
R
W
F
I
F
P
--------
127
Fugue
87.03
30%
-114
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
-----
G
V
-
E
K
I
Y
P
GGARSV-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
------
P
Q
K
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
---
R
E
K
----
R
V
P
K
D
E
M
D
A
R
V
R
E
---
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
-
G
T
L
F
V
A
S
F
I
G
E
-
S
---
N
V
W
T
-
R
A
V
---------------
Q
-
N
---
G
R
I
E
V
A
G
A
A
----
L
---
P
V
DP
A
-
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
-
P
A
S
E
R
E
-------
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
------
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
-------
106
HHSearch
85.54
31%
-115
- C1 -
4TQU
-
?
S:
[14-360]
-------------
Y
D
-
K
T
T
V
V
-------
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
N
D
------
L
A
P
K
D
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
L
---
R
L
K
R
----
T
K
K
S
V
I
D
A
A
V
K
T
---
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
-
A
N
T
F
V
A
S
-
F
I
G
-
S
PPM
N
L
M
P
-
A
R
I
--
A
V
D
S
-
T
QH
V
--
E
-
L
-
N
---
G
G
N
R
I
S
L
L
P
RA--
G
---
T
---
H
-
L
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
D
-
G
V
E
--
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
---
G
D
H
S
L
V
V
K
V
G
G
----
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
---
128
Fugue
82.29
26%
-107
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
-----
N
V
-
S
K
V
F
K
KGKVVAL
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
-
N
G
K
L
I
V
P
P
E
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
---
T
N
M
----
K
M
S
K
E
E
I
R
K
R
V
E
E
---
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
-
V
S
I
Q
V
A
S
-
L
I
G
E
I
---
N
E
L
E
-
G
K
V
--
T
N
E
G
-----------------
V
V
I
G
S
L
R
----
F
---
P
---
V
-
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
--
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
-------
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
-------
105
HHSearch
81.63
30%
-112
- C1 -
3D31
2
?
A:
[11-348]
-------------
W
K
--
N
F
S
L
-------
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
K
D
V
T
D
------
L
S
P
E
K
H
D
-
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
---
R
M
K
K
----
I
---
K
D
P
K
R
V
L
D
---
T
A
R
D
L
K
I
E
H
-
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
-
V
E
G
R
V
A
S
-
F
V
G
-
F
E
--
N
V
L
K
-
G
R
V
--
I
S
A
E
-
Q
G
L
L
--
R
-
I
-
R
---
V
G
E
V
V
I
D
A
A
--------
G
---
D
-
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
A
L
S
-
K
S
S
T
Q
S
--
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
C
---
G
-
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
L
R
--------
111
HHSearch
80.27
28%
-103
- C1 -
2YYZ
3
?
A:
[13-355]
-------------
F
G
-
K
V
K
A
V
-------
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
N
D
------
I
P
P
K
Y
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
L
---
R
A
R
R
----
I
S
K
D
E
V
E
K
R
V
V
E
---
I
A
R
K
L
L
I
D
N
-
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
-
K
N
M
F
V
A
S
-
F
I
G
-
N
P
P
T
N
F
L
R
-
D
F
S
--
V
S
V
E
N
K
--
Q
--
T
I
L
K
R
---
D
D
V
I
I
K
L
P
E
--------
P
---
V
-
D
V
K
L
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
-
R
E
R
------
V
E
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
--
K
G
E
I
I
K
V
F
G
----
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
----
5
PsiBlast_PDB
80.07
29%
-115
- C1 -
3D31
2
?
A:
[18-344]
-----------------------------
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
------
R
I
L
L
D
G
K
D
V
T
D
L
S
P
E
K
H
D
-
I
A
F
V
Y
Q
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
---
R
M
K
K
-------
I
K
D
P
K
R
V
L
D
---
T
A
R
D
L
K
I
E
H
-
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
-
V
G
F
-
E
---
N
V
L
K
-
G
R
V
IS
A
E
Q
G
-
L
--
L
--
R
-
I
-
R
---
V
G
E
V
V
I
D
A
-----
A
---
G
---
D
-
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
A
L
S
-
K
S
S
T
Q
S
--
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
---
V
D
C
G
V
P
-
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
------------
108
HHSearch
78.86
29%
-107
- C1 -
2IT1
-
?
A:
[13-356]
-------------
F
G
-
N
F
T
A
L
-------
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
------
L
P
P
K
D
R
N
-
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
---
E
L
R
K
----
A
P
R
E
E
I
D
K
K
V
R
E
---
V
A
K
M
L
H
I
D
K
-
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
-
K
Y
K
F
V
G
G
-
F
L
G
-
N
P
P
M
N
F
V
E
-
A
K
V
--
E
D
G
K
-
L
--
V
--
I
-
T
-
E
---
K
S
K
-
L
P
I
P
K
QY
V
E
I
---
V
---
K
-
E
T
G
I
T
E
V
I
I
G
F
R
P
H
D
A
E
I
V
-
K
G
E
-------
G
E
G
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
---
D
S
I
V
K
V
F
A
P
----
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
--
113
HHSearch
75.45
26%
-97
- C1 -
1OXX
21
?
K:
[18-352]
-----------------
V
V
A
L
-------
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
-
K
L
I
V
P
P
E
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
---
T
N
M
K
----
M
S
K
E
E
I
R
K
R
V
E
E
---
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
-
V
S
I
Q
V
A
S
-
L
I
G
-
E
I--
N
E
L
E
-
G
K
V
--
T
N
E
G
-
V
--
V
--
I
-------
G
S
L
R
F
P
---------------
V
-
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
-
K
D
V
I
K
D
D-
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
--
D
-
S
E
E
E
I
----
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
-------
107
HHSearch
75.18
26%
-106
- C1 -
1V43
-
?
A:
[22-370]
-------------
F
G
-
N
F
T
A
V
-------
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
------
L
P
P
K
D
R
N
-
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
L
-----
K
K
----
F
P
K
D
E
I
D
K
R
V
R
W
---
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
-
N
S
V
F
V
A
T
-
F
I
G
-
A
PEM
N
I
L
E
-
V
S
V
--
G
D
G
Y
-
L
-----
E
---
G
---
R
G
F
R
I
E
L
P
Q
-----MDL
L
---
K
-
D
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
-
G
V
----HM
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
---
G
D
E
L
V
K
V
K
L
P
G
----
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
---
14
PsiBlast_PDB
73.06
36%
-122
- C1 -
3PUZ
2
MALK_ECOLI
A:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.00
36%
-121
- C1 -
3PUZ
2
MALK_ECOLI
B:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.83
36%
-118
- C1 -
3PUX
5
MALK_ECOLI
A:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.76
36%
-119
- C1 -
3PUV
5
MALK_ECOLI
A:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.73
36%
-114
- C1 -
3PUY
3
MALK_ECOLI
A:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
71.39
31%
-112
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[22-291]
-----------------------------
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
--
T
N
L
P
V
R
E
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
----------
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
IEA
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
-
A
D
L
D
A
A
L
-
F
I
G
-
E
---
G
I
V
F
P
A
A
L
--
N
A
D
G
-
T
--
A
--
D
-
C
-
R
---
L
G
R
----
L
P
----
V
---
Q
---
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
----
P
H
S
--
A
P
-------------------------------------------------------------------------
17
PsiBlast_PDB
71.34
36%
-117
- C1 -
3PUW
5
MALK_ECOLI
A:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.21
40%
-119
- C1 -
1Z47
1
?
B:
[34-247]
------------------------------
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
K
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
---
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
-
E
L
L
R
---
F
M
R
---
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
-
G
T
L
F
V
A
S
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.14
36%
-120
- C1 -
2R6G
2
MALK_ECOLI (first)
B:
[21-235]
-----------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
P
A
------
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
---
K
----
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
-
A
D
R
F
V
A
G
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
69.16
36%
-115
- C1 -
4U00
3
?
A:
[23-231]
------------------------------
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
A
L
R
E
I
R
---
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
R
R
W
----
P
R
E
K
A
E
K
K
A
L
E
---
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
-
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
-
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
65.94
33%
-109
- C1 -
4YMV
1
?
A:
[20-230]
------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
-
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
---
V
K
V
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
---
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
-
K
N
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
65.29
35%
-121
- C1 -
3C4J
4
?
B:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
64.26
35%
-118
- C1 -
2OLK
1
?
C:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.97
33%
-111
- C1 -
4YMV
1
?
J:
[20-230]
------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
-
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
---
V
K
V
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
---
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
-
K
N
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
63.78
35%
-119
- C1 -
3C41
3
?
J:
[22-230]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
63.65
35%
-119
- C1 -
2OLK
2
?
B:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
63.46
35%
-119
- C1 -
2OLK
1
?
D:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
63.35
35%
-114
- C1 -
3C4J
3
?
A:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
63.30
35%
-119
- C1 -
2OLJ
4
?
A:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
63.23
33%
-108
- C1 -
4YMU
2
?
A:
[20-230]
------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
-
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
---
V
K
V
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
---
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
-
K
N
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
63.18
35%
-117
- C1 -
2OLK
1
?
A:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
63.11
35%
-114
- C1 -
2Q0H
4
?
A:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
62.99
33%
-108
- C1 -
4YMU
2
?
J:
[20-230]
------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
-
D
G
V
K
I
N
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
---
V
K
V
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
---
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
-
K
N
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
62.80
35%
-121
- C1 -
3C41
3
?
K:
[22-230]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
61.69
35%
-117
- C1 -
2Q0H
4
?
B:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
60.11
35%
-118
- C1 -
2OLJ
3
?
B:
[43-251]
------------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
---
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
---
M
K
V
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
---
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
59.03
32%
-115
- C1 -
4P32
2
LPTB_ECOLI
A:
[20-224]
-----------------------------
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
----
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
-
E
D
R
A
N
E
L
-----
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.01
31%
-110
- C1 -
4P33
7
LPTB_ECOLI
A:
[20-224]
-----------------------------
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
----
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
-
E
D
R
A
N
E
L
-----
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
58.91
32%
-113
- C1 -
4P32
2
LPTB_ECOLI
B:
[20-224]
-----------------------------
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
----
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
-
E
D
R
A
N
E
L
-----
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
58.82
31%
-107
- C1 -
4P33
6
LPTB_ECOLI
B:
[20-224]
-----------------------------
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
----
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
-
E
D
R
A
N
E
L
-----
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
58.74
32%
-108
- C1 -
4QC2
2
?
B:
[21-225]
-----------------------------
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
----
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
-
E
D
R
A
N
E
L
-----
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
56.69
32%
-107
- C1 -
4QC2
2
?
A:
[21-225]
-----------------------------
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
----
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
-
E
D
R
A
N
E
L
-----
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
-
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
55.69
34%
-108
- C1 -
1L2T
4
Y796_METJA
B:
[23-223]
-----------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
LIF
K
Y
R
G
A
M
S
G
E
E
R
---
R
K
R
A
L
E
---
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
55.65
34%
-106
- C1 -
1L2T
4
Y796_METJA
A:
[23-223]
-----------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
LIF
K
Y
R
G
A
M
S
G
E
E
R
---
R
K
R
A
L
E
---
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
54.82
34%
-106
- C1 -
3TIF
7
Y796_METJA
A:
[23-223]
-----------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
LIF
K
Y
R
G
A
M
S
G
E
E
R
---
R
K
R
A
L
E
---
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
54.82
34%
-110
- C1 -
3TIF
6
Y796_METJA
B:
[23-223]
-----------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
LIF
K
Y
R
G
A
M
S
G
E
E
R
---
R
K
R
A
L
E
---
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------