@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1869c: (2016-05-05 )
MASSTTFVIVGGGLAGAKAVEALRRSDFGGRIILFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSDWYRDHDVDVRLGVRVSSLDRSAHTVELPDGAAVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEITAADGKATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGRPGEYAELPYLFTDQYDLGMEYVGHAPSCDRVVFRGNVAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRLVDPQWPLADLTTN
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..120--..---......130.......140.......150.......160.......170.......180.......190.......200.......---------210--......--.220.......230.......240.......250.......260.......270.......280......-.290.......300.......310....-..--.320.......330.......340.......350---.--......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAS
S
T
T
F
V
I
VGGGLA
G
A
K
A
V
E
A
L
R
RSDFG
G
R
I
I
L
F
GDEEHLPYDRPPL
S
K
E
F
L
AGKKSLS
D
F
T
I
QTSDWYRDHD
V
D
V
R
L
G
V
R
V
SSLDRSA
H
T
V
ELPDG
A
A
V
R
Y
D
K
L
L
L
ATGSAPRRP-PIPG---SD---A
A
G
V
H
Y
L
R
SYN
D
A
V
A
L
N
S
V
LVQGS
S
L
A
V
V
GA
G
W
I
G
L
E
V
A
A
S
A
R
QRGVD
V
T
V
V
E
T
A
I
Q
P
L
L
A
A
L
G
E
A
V
G
K
V
F
A
D
L
H
RDQGV
D
L
R
L
Q
T
---------
Q
L
E
--
E
I
TAAD--GKAT
G
L
K
MRDGS
T
V
AA
D
A
V
L
V
A
VGAKP
N
V
E
L
A
Q
Q
AGLAMGEG
G
V
L
V
D
A
SLRTSDP
D
I
Y
A
VGDIAAAEHPL-LG
T
R
V
R
T
E
H
W
A
N
A
L
KQ
P
A
V
A
A
AGMLGRP-GE--YAEL
P
Y
L
FTD
Q
Y
D
L
G
M
E
Y
VGHAPSC
D
R
V
V
F
RGNV---A--
G
R
E
F
L
S
F
W
LDGD
S
R
V
L
A
GMNV
N
V
W
D
V
V
D
D
V
K
G
L
IRSGNPV
D
V
D
RLVDPQWPLADLTTN
2
PsiBlast_PDB
96.13
36%
-110
- C1 -
1Q1R
1
CAMA_PSEPU
A:
[2-411]
-
N
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
GAV
G
K
---
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
G
F
E
M
S
T
D
Q
--
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
-
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
I
V
R
G
S
L
---
A
--
Q
P
D
F
S
V
F
Y
L
Q
G
D
-
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
---
22
PsiBlast_CBE
96.06
36%
-109
- C1 -
1Q1R
1
CAMA_PSEPU
B:
[2-411]
-
N
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
GAV
G
K
---
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
GF
E
M
S
T
D
Q
--
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
-
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
I
V
R
G
S
L
---
A
--
Q
P
D
F
S
V
F
Y
L
Q
G
D
-
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
---
4
PsiBlast_PDB
96.00
36%
-111
- C1 -
3LB8
1
CAMA_PSEPU
A:
[2-410]
--
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
GAV
G
K
---
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
G
F
E
M
S
T
D
Q
--
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
-
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
I
V
R
G
S
L
---
A
--
Q
P
D
F
S
V
F
Y
L
Q
G
D
-
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
---
21
PsiBlast_CBE
94.76
36%
-110
- C1 -
1Q1W
1
CAMA_PSEPU
B:
[3-411]
--
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
GAV
G
K
---
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
G
F
E
M
S
T
D
Q
--
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
-
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
I
V
R
G
S
L
---
A
--
Q
P
D
F
S
V
F
Y
L
Q
G
D
-
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
---
3
PsiBlast_PDB
94.09
36%
-109
- C1 -
1Q1W
1
CAMA_PSEPU
A:
[2-411]
-
N
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
GAV
G
K
---
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
G
F
E
M
S
T
D
Q
--
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
-
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
I
V
R
G
S
L
---
A
--
Q
P
D
F
S
V
F
Y
L
Q
G
D
-
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
---
17
PsiBlast_PDB
93.11
38%
-107
- C1 -
4H4P
10
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
Q
T
K
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
13
PsiBlast_PDB
93.08
38%
-106
- C1 -
2YVF
7
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
10
PsiBlast_PDB
92.98
38%
-108
- C1 -
2GR0
2
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
16
PsiBlast_PDB
92.95
38%
-106
- C1 -
4H4Q
6
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
Q
T
K
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
14
PsiBlast_PDB
92.90
38%
-107
- C1 -
2YVG
2
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
23
PsiBlast_CBE
92.82
36%
-110
- C1 -
3LB8
1
CAMA_PSEPU
B:
[2-410]
--
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
GAV
G
K
---
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
GF
E
M
S
T
D
Q
--
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
-
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
I
V
R
G
S
L
---
A
--
Q
P
D
F
S
V
F
Y
L
Q
G
D
-
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
---
20
PsiBlast_PDB
92.72
38%
-108
- C1 -
4H4S
3
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
C
T
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
25
PsiBlast_CBE
92.46
38%
-107
- C1 -
4H4R
12
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
C
T
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
9
PsiBlast_PDB
92.40
38%
-106
- C1 -
2GQW
7
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
27
PsiBlast_CBE
92.31
37%
-107
- C1 -
4H4Z
10
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
Q
R
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
11
PsiBlast_PDB
91.86
38%
-106
- C1 -
2GR1
1
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
69
HHSearch
91.81
36%
-105
- C1 -
1Q1R
1
CAMA_PSEPU
A:
[2-412]
-
N
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
G
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
V
A
S
---
G
A
VGK
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
---------
Q
V
C
--
G
F
E
M
S
T
DQ
Q
K
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
D
-
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
-
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
-
P
R
--
D
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
-
I
V
R
G
S
L--
A
--
Q
P
D
F
S
V
F
Y
-
L
Q
G
D
R
V
L
A
V
D
T
V
N
R
P
V
E
F
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
I
--
28
PsiBlast_CBE
91.80
37%
-106
- C1 -
4H4Y
11
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
A
R
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
12
PsiBlast_PDB
91.71
38%
-107
- C1 -
2GR2
2
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
26
PsiBlast_CBE
91.69
37%
-107
- C1 -
4H50
8
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
Q
R
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
71
HHSearch
91.16
37%
-100
- C1 -
2GQW
7
?
A:
[6-403]
--
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
G
D
-
A
E
K
I
R
L
---
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
---
A
T
----
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
T
--
G
S
V
D
G
-------
V
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
D
-
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
A
P
G
--
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
--
I
V
R
G
E
VSL
D
--
A
P
K
F
T
L
I
E
-
L
Q
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
A
--
29
PsiBlast_CBE
91.08
37%
-106
- C1 -
4H4X
10
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
A
R
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
19
PsiBlast_PDB
91.04
38%
-106
- C1 -
4H4T
14
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
R
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
30
PsiBlast_CBE
90.87
37%
-107
- C1 -
4H4W
7
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
C
R
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
6
PsiBlast_PDB
90.82
38%
-105
* C1 *
2GR3
3
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
F
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
18
PsiBlast_PDB
90.81
38%
-106
- C1 -
4H4U
9
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
R
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
31
PsiBlast_CBE
90.67
37%
-106
- C1 -
4H4V
14
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
C
R
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
24
PsiBlast_CBE
89.07
38%
-105
- C1 -
2YVJ
2
?
P:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
PG
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
8
PsiBlast_PDB
88.49
38%
-102
- C1 -
1F3P
2
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
7
PsiBlast_PDB
87.02
38%
-98
- C1 -
1D7Y
1
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
15
PsiBlast_PDB
86.84
38%
-103
- C1 -
2YVJ
2
?
A:
[11-402]
-------
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
----
G
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
----
T
G
S
V
D
--
G
V
---
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
-
G
I
A
V
A
R
H
L
V
D
P
-
T
A
P
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
-
S
G
D
E
E
I
V
R
G
E
V
---
S
LD
A
P
K
F
T
L
I
E
L
Q
-
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
---
74
HHSearch
86.36
32%
-101
- C1 -
3FG2
2
?
P:
[1-403]
---
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
K
Y
P
G
R
I
A
L
I
N
D
E
K
H
L
P
Y
Q
R
P
P
L
S
K
A
Y
L
K
S
G
G
D
P
N
S
L
M
F
R
P
E
K
F
F
Q
D
Q
A
I
E
L
I
-
S
D
R
M
V
S
I
D
R
E
G
R
K
L
L
L
A
S
G
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
-
D
V
P
N
---
A
S
---
L
P
D
V
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
P
D
K
K
H
V
V
V
I
G
A
G
F
I
G
L
E
F
A
A
T
A
R
A
K
G
L
E
V
D
V
V
E
L
A
P
R
V
M
A
R
V
V
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
---------
R
A
T
--
E
I
A
A
E
G
--
D
R
V
T
G
V
V
L
S
D
G
N
T
L
P
C
D
L
V
V
V
G
V
G
V
I
P
N
V
E
I
A
A
A
A
G
L
P
T
A
-
A
G
I
I
V
D
Q
Q
L
L
T
S
D
P
H
I
S
A
I
G
D
C
A
L
F
E
S
V
R
-
F
G
E
T
M
R
V
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
D
A
-
K
P
--
Y
D
G
Y
P
W
F
W
S
D
Q
G
D
D
K
L
Q
I
V
G
L
T
A
G
F
D
-
Q
V
V
I
R
G
S
V--
A
--
E
R
S
F
S
A
F
C
-
Y
K
A
G
K
L
I
G
I
E
S
V
N
R
A
A
D
H
V
F
G
R
K
I
L
P
L
D
K
S
V
T
P
E
Q
A
A
D
L
S
F
D
L
K
K
A
A
--
59
Fugue
83.16
36%
-92
- C1 -
1D7Y
1
?
A:
[5-405]
-
A
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
K
D
F
M
A
H
G
----
D
A
E
K
I
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
Q
---
G
A
---
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
---------
S
V
T
--
G
S
V
D
-------
G
V
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
-
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
-
A
P
G
-
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
V
R
G
E
V
S
---
L
--
D
A
P
K
F
T
L
I
E
L
Q
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
A
A
A
70
HHSearch
82.23
33%
-97
- C1 -
3EF6
10
TODA_PSEP1
A:
[3-402]
----
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
K
A
V
L
D
G
S
L
E
R
P
-
P
I
L
A
E
A
D
W
Y
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D
G
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
L
P
G
---
S
Q
---
L
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
T
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
---------
G
V
V
--
G
F
S
G
E
---
G
Q
L
E
Q
V
M
A
S
D
G
R
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
D
-
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
W
P
L
R
A
-
G
G
-
R
R
S
L
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
-
V
S
--
A
P
Q
L
P
V
S
W
T
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
F
-
V
S
R
G
M
P--
G
--
S
G
A
A
L
L
F
R
-
L
Q
E
R
R
I
Q
A
V
V
A
V
D
A
P
R
D
F
A
L
A
T
R
L
V
E
A
R
A
A
I
E
P
A
R
L
A
D
L
S
N
S
M
R
D
F
V
--
5
PsiBlast_PDB
80.86
35%
-104
- C1 -
3FG2
2
?
P:
[3-356]
-----
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
K
Y
P
G
R
I
A
L
I
N
D
E
K
H
L
P
Y
Q
R
P
P
L
S
K
A
Y
L
K
S
G
G
D
P
N
S
L
M
F
R
P
E
K
F
F
Q
D
Q
A
I
E
L
-
I
S
D
R
M
V
S
I
D
R
E
G
R
K
L
L
L
A
S
G
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
-
D
V
P
N
---
A
S
---
L
P
D
V
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
P
D
K
K
H
V
V
V
I
G
A
G
F
I
G
L
E
F
A
A
T
A
R
A
K
G
L
E
V
D
V
V
E
L
A
P
R
V
M
A
R
V
V
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
---------
R
A
T
--
E
I
A
A
E
G
--
D
R
V
T
G
V
V
L
S
D
G
N
T
L
P
C
D
L
V
V
V
G
V
G
V
I
P
N
V
E
I
A
A
A
A
-
G
L
P
T
A
A
G
I
I
V
D
Q
Q
L
L
T
S
D
P
H
I
S
A
I
G
D
C
A
L
F
E
S
V
R
-
F
G
E
T
M
R
V
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
D
A
-
K
P
--
Y
D
G
Y
P
W
F
W
S
D
Q
G
D
D
K
L
Q
I
V
G
L
T
A
G
F
D
Q
V
V
I
R
G
S
V
---
A
--
E
R
S
F
S
A
F
C
--------------------------------------------------
32
PsiBlast_CBE
72.79
36%
-97
- C1 -
4EMJ
1
TODA_PSEP1
A:
[2-344]
---
A
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
K
A
V
L
D
G
S
L
E
R
P
P
I
-
L
A
E
A
D
W
Y
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D
G
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
L
P
G
---
S
Q
---
L
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
T
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
GVV
G
F
S
G
E
G
Q
L
E
--
Q
V
M
A
S
D
--
G
R
----------
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
-
D
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
--
W
P
L
R
A
G
G
R
R
S
L
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
-
V
S
--
A
P
Q
L
P
V
S
W
T
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
F
V
S
R
G
------------------------------------------------------------------
33
PsiBlast_CBE
72.25
36%
-97
- C1 -
4EMI
2
TODA_PSEP1
A:
[2-344]
---
A
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
K
A
V
L
D
G
S
L
E
R
P
P
I
-
L
A
E
A
D
W
Y
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D
G
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
L
P
G
---
S
Q
---
L
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
T
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
GVV
G
F
S
G
EG
Q
L
E
--
Q
V
M
A
S
D
--
G
R
----------
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
-
D
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
--
W
P
L
R
A
G
G
R
R
S
L
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
-
V
S
--
A
P
Q
L
P
V
S
W
T
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
F
V
S
R
G
------------------------------------------------------------------
34
PsiBlast_CBE
72.23
36%
-97
- C1 -
3EF6
9
TODA_PSEP1
A:
[3-344]
----
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
K
A
V
L
D
G
S
L
E
R
P
P
I
-
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