@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1872c: (2016-05-05 )
MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGAEDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLYMWRDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLDRWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRHVTQLRRLGPIGAPT
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..---...-..120.......--130.......140.......150--....--...160.......170.......180.......190.......200---........210.......220.......230.......240......--..250.......260.......270.......280.......290.......300.......310.......-----320.-----......330.......340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVNRRV
P
R
V
R
D
L
A
P
L
L
QFNRPQFD
T
S
K
R
RLG
A
A
L
T
I
Q
D
L
R
R
I
A
K
RRTPRAAFDYADGGAE
D
E
L
S
I
A
R
A
RQGFRDIEF
H
P
T
I
L
R
D
V
T
T
V
C
AGWNVLGQP
T
V
L
P
FGIA
P
T
G
F
T
R
L
---MHT-EGEIAGARAAAA--AGIP
F
S
L
S
T
L
A
T
C
A
I
E
D
L
V
I
AVP--QG
R
K
--
W
F
Q
L
Y
M
WRDRD
R
S
M
A
L
V
R
R
V
A
AAGF
D
T
M
L
V
T
V
DVPVA
G
A
R
L
R
D
V
R----NGMSIP
P
A
L
T
L
R
T
V
L
D
AMGH
P
R
W
W
F
D
LLTTEP
L
A
F
ASLDR-WP
G
T
V
G
--
E
Y
L
N
T
VFDPSL
T
F
D
D
L
A
W
I
K
SQWPG
K
L
V
V
K
G
I
Q
T
L
D
D
A
R
A
V
V
DRGV
D
G
I
V
LSNHGGRQLDRAPV
P
F
H
L
L
P
H
V
-----
A
R
E
L-----GKH
T
E
I
L
V
DTGIMS
G
A
D
I
V
A
A
I
ALGA
R
C
T
L
I
G
R
A
Y
L
Y
G
L
MAGG
E
A
G
V
N
R
A
I
E
I
L
Q
T
G
V
I
R
T
M
R
L
L
G
V
T
C
L
E
EL
S
P
R
H
V
T
Q
L
R
RLGPIGAPT
54
HHSearch
95.86
36%
-107
- C5 -
1GOX
2
GOX_SPIOL
A:
[2-358]
--------------------------------
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
---
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
---
P
G
I
R
--
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
----
N
R
F
V
L
P
P
F
L
T
L
K
N
F
E
G
I
----------------
D
L
G
---------
L
S
--
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
-----
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
A
A
D
W
---------
14
PsiBlast_PDB
94.89
35%
-110
- C5 -
1GOX
1
GOX_SPIOL
A:
[5-354]
-----------------------------------
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
---
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
P
---
G
I
R
--
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
----
N
R
F
V
L
P
P
F
L
T
L
K
N
F
----------------
E
G
I
D
L
G
---------
L
S
--
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
-----
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
-------------
52
HHSearch
94.85
38%
-107
- C5 -
1P4C
3
GOX_SPIOL
A:
[4-356]
--------------------------------
N
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
-
C
--
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
F
E
G
I
----------------
D
L
G
K
M
D
K
A
N
L
E
M
Q
A
--
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-------
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
E
----------
5
PsiBlast_PDB
93.94
36%
-111
- C5 -
2A7P
3
GOX_SPIOL (first)
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
K
A
N
L
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
7
PsiBlast_PDB
93.80
36%
-109
- C5 -
3GIY
2
MDLB_PSEPU
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
K
A
N
L
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
2
PsiBlast_PDB
93.70
37%
-107
- C5 -
1P4C
3
GOX_SPIOL
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
K
A
N
L
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
3
PsiBlast_PDB
93.47
37%
-108
- C5 -
1P5B
3
GOX_SPIOL (first)
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
K
A
N
L
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
4
PsiBlast_PDB
93.46
36%
-110
- C5 -
2A7N
2
GOX_SPIOL
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
K
A
N
L
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
6
PsiBlast_PDB
93.34
36%
-108
- C5 -
2A85
3
GOX_SPIOL
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
K
A
N
L
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
13
PsiBlast_PDB
93.02
35%
-116
- C5 -
1AL8
2
GOX_SPIOL
A:
[5-354]
-----------------------------------
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
---
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
P
---
G
I
R
--
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
------
I
K
----
N
R
F
V
L
P
P
F
L
T
L
K
N
F
----------------
E
G
I
D
L
G
---------
L
S
--
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
-----
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
-------------
12
PsiBlast_PDB
92.60
35%
-106
- C5 -
1AL7
2
GOX_SPIOL
A:
[5-354]
-----------------------------------
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
---
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
P
---
G
I
R
--
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
----
N
R
F
V
L
P
P
F
L
T
L
K
N
F
----------------
E
G
I
D
L
G
---------
L
S
--
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
-----
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
-------------
1
PsiBlast_PDB
92.42
37%
-113
- C5 -
1HUV
3
GOX_SPIOL (first)
A:
[6-355]
----------------------------------
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
---
L
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
G
D
L
--
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
----
N
R
F
K
I
P
P
F
L
T
L
K
N
-----------
F
E
G
I
D
L
G
K
M
D
----
E
M
-
Q
A
A
L
M
S
--
R
Q
M
----
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
-----
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
-----------
11
PsiBlast_PDB
91.83
33%
-110
- C5 -
2RDW
2
HAOX1_HUMAN
A:
[23-365]
----------------------------------
I
C
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
---
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
P
--
E
A
L
R
--
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
----
N
R
F
K
L
P
P
Q
L
R
M
K
N
--------------
F
E
T
S
T
L
S
F
S
P
E
E
N
-
F
G
D
D
S
G
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
-----
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
-------------------------
10
PsiBlast_PDB
91.44
33%
-109
- C5 -
2RDU
2
HAOX1_HUMAN
A:
[23-365]
----------------------------------
I
C
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
---
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
P
--
E
A
L
R
--
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
----
N
R
F
K
L
P
P
Q
L
R
M
K
N
--------------
F
E
T
S
T
L
S
F
S
P
E
E
N
-
F
G
D
D
S
G
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
-----
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
-------------------------
53
HHSearch
88.36
34%
-105
* C5 *
3SGZ
2
HAOX2_RAT
A:
[2-350]
---------------------------------
L
V
C
L
A
D
F
K
A
H
A
Q
K
Q
L
S
K
T
S
W
D
F
I
E
G
E
A
D
D
G
I
T
Y
S
E
N
I
A
A
F
K
R
I
R
L
R
P
R
Y
L
R
D
M
S
K
V
D
T
R
T
T
I
Q
G
Q
E
I
S
A
P
I
C
I
S
P
T
A
F
H
S
I
---
A
W
P
-
D
G
E
K
S
T
A
R
A
A
Q
E
--
A
N
I
C
Y
V
I
S
S
Y
A
S
Y
S
L
E
D
I
V
A
A
A
P
--
E
G
F
R
--
W
F
Q
L
Y
M
K
S
D
W
D
F
N
K
Q
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
D
T
P
V
L
G
N
R
R
R
D
K
R
----
N
Q
L
N
L
E
A
N
I
L
K
A
A
----
L
------------------------------------
F
P
K
A
S
F
C
W
N
D
L
S
L
L
Q
S
I
T
R
L
P
I
I
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
S
A
S
I
D
A
L
R
E
V
-----
V
A
A
V
-----
K
G
K
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
I
L
T
A
E
L
H
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
D
L
I
Q
F
S
----------
55
HHSearch
88.13
33%
-100
- C5 -
1KBI
6
CYB2_YEAST
A:
[109-485]
--------------------
K
E
Q
L
K
S
L
L
P
P
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
---
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
SD
K
Q
I
Q
--
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
----
L
K
F
S
N
T
---------------------------
K
K
T
N
V
E
E
-
S
Q
G
A
-
S
--
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
-----
M
P
I
L
E
Q
RNL
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
D
L
S
T
L
K
A
------
25
PsiBlast_CBE
87.80
32%
-106
- C5 -
1TB3
2
HAOX2_RAT
G:
[3-349]
----------------------------------
V
C
L
A
D
F
K
A
H
A
Q
K
Q
L
S
K
T
S
W
D
F
I
E
G
E
A
D
D
G
I
T
Y
S
E
N
I
A
A
F
K
R
I
R
L
R
P
R
Y
L
R
D
M
S
K
V
D
T
R
T
T
I
Q
G
Q
E
I
S
A
P
I
C
I
S
P
T
A
F
H
S
I
---
A
W
P
-
D
G
E
K
S
T
A
R
A
A
Q
E
--
A
N
I
C
Y
V
I
S
S
Y
A
S
Y
S
L
E
D
I
V
A
A
A
P
--
E
G
F
R
--
W
F
Q
L
Y
M
K
S
D
W
D
F
N
K
Q
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
D
T
P
V
L
G
N
R
R
R
D
K
R
----
N
Q
L
N
L
E
A
--------
R
A
L
K
E
-------------------------------------
A
S
F
C
W
N
D
L
S
L
L
Q
S
I
T
R
L
P
I
I
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
S
A
S
I
D
A
L
R
E
V
-----
V
A
A
V
-----
K
G
K
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
I
L
T
A
E
L
H
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
-
D
L
I
Q
F
----------
30
PsiBlast_CBE
87.68
32%
-106
- C5 -
1TB3
2
HAOX2_RAT
B:
[3-349]
----------------------------------
V
C
L
A
D
F
K
A
H
A
Q
K
Q
L
S
K
T
S
W
D
F
I
E
G
E
A
D
D
G
I
T
Y
S
E
N
I
A
A
F
K
R
I
R
L
R
P
R
Y
L
R
D
M
S
K
V
D
T
R
T
T
I
Q
G
Q
E
I
S
A
P
I
C
I
S
P
T
A
F
H
S
I
---
A
W
P
-
D
G
E
K
S
T
A
R
A
A
Q
E
--
A
N
I
C
Y
V
I
S
S
Y
A
S
Y
S
L
E
D
I
V
A
A
A
P
--
E
G
F
R
--
W
F
Q
L
Y
M
K
S
D
W
D
F
N
K
Q
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
D
T
P
V
L
G
N
R
R
R
D
K
R
----
N
Q
L
N
L
E
A
---------
A
L
K
--------------------------------------
A
S
F
C
W
N
D
L
S
L
L
Q
S
I
T
R
L
P
I
I
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
S
A
S
I
D
A
L
R
E
V
-----
V
A
A
V
-----
K
G
K
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
I
L
T
A
E
L
H
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
-
D
L
I
Q
F
----------
28
PsiBlast_CBE
87.54
32%
-107
- C5 -
1TB3
2
HAOX2_RAT
D:
[3-349]
----------------------------------
V
C
L
A
D
F
K
A
H
A
Q
K
Q
L
S
K
T
S
W
D
F
I
E
G
E
A
D
D
G
I
T
Y
S
E
N
I
A
A
F
K
R
I
R
L
R
P
R
Y
L
R
D
M
S
K
V
D
T
R
T
T
I
Q
G
Q
E
I
S
A
P
I
C
I
S
P
T
A
F
H
S
I
---
A
W
P
-
D
G
E
K
S
T
A
R
A
A
Q
E
--
A
N
I
C
Y
V
I
S
S
Y
A
S
Y
S
L
E
D
I
V
A
A
A
P
--
E
G
F
R
--
W
F
Q
L
Y
M
K
S
D
W
D
F
N
K
Q
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
D
T
P
V
L
G
N
R
R
R
D
K
R
----
N
Q
L
N
L
E
A
-------
L
R
A
L
K
--------------------------------------
A
S
F
C
W
N
D
L
S
L
L
Q
S
I
T
R
L
P
I
I
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
S
A
S
I
D
A
L
R
E
V
-----
V
A
A
V
-----
K
G
K
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
I
L
T
A
E
L
H
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
-
D
L
I
Q
F
----------
29
PsiBlast_CBE
87.40
32%
-105
- C5 -
1TB3
2
HAOX2_RAT
C:
[3-349]
----------------------------------
V
C
L
A
D
F
K
A
H
A
Q
K
Q
L
S
K
T
S
W
D
F
I
E
G
E
A
D
D
G
I
T
Y
S
E
N
I
A
A
F
K
R
I
R
L
R
P
R
Y
L
R
D
M
S
K
V
D
T
R
T
T
I
Q
G
Q
E
I
S
A
P
I
C
I
S
P
T
A
F
H
S
I
---
A
W
P
-
D
G
E
K
S
T
A
R
A
A
Q
E
--
A
N
I
C
Y
V
I
S
S
Y
A
S
Y
S
L
E
D
I
V
A
A
A
P
--
E
G
F
R
--
W
F
Q
L
Y
M
K
S
D
W
D
F
N
K
Q
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
D
T
P
V
L
G
N
R
R
R
D
K
R
----
N
Q
L
N
L
E
A
----
K
D
-
L
R
A
L
K
E
-------------------------------------
A
S
F
C
W
N
D
L
S
L
L
Q
S
I
T
R
L
P
I
I
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
S
A
S
I
D
A
L
R
E
V
-----
V
A
A
V
-----
K
G
K
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
I
L
T
A
E
L
H
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
-
D
L
I
Q
F
----------
35
PsiBlast_CBE
87.08
31%
-107
- C5 -
1SZF
2
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F-----------------------
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
50
PsiBlast_CBE
86.46
31%
-111
- C5 -
1QCW
1
CYB2_YEAST
A:
[18-374]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
K
E
K
D
M
K
L
K
FS-----------------------------------------------------
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
46
PsiBlast_CBE
86.36
31%
-106
- C5 -
1SZE
2
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
KF--------------------
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
37
PsiBlast_CBE
85.94
31%
-110
- C5 -
1KBI
6
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
T
-------
K
K
T
N
V
E
E
S
Q
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
49
PsiBlast_CBE
85.88
31%
-110
- C5 -
1QCW
1
CYB2_YEAST
B:
[18-374]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
IQ
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
K
E
K
D
M
K
LKFS-----------------------------------------------------
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
MPILE
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
38
PsiBlast_CBE
85.67
31%
-106
- C5 -
1FCB
2
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
FS------------
N
V
E
E
S
Q
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
36
PsiBlast_CBE
85.48
31%
-108
- C5 -
1KBI
3
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
T
--------
K
T
N
V
E
E
S
Q
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
44
PsiBlast_CBE
84.99
31%
-107
- C5 -
1LCO
3
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S----------------------
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
42
PsiBlast_CBE
84.82
31%
-106
- C5 -
1LDC
3
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K------------------------
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
33
PsiBlast_CBE
84.61
31%
-107
- C5 -
1KBJ
2
CYB2_YEAST
B:
[20-376]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F--------------------
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
20
PsiBlast_PDB
84.28
31%
-107
- C5 -
1FCB
2
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
-----------------
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
43
PsiBlast_CBE
84.19
31%
-103
- C5 -
1LCO
2
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K-------------------
Q
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
18
PsiBlast_PDB
83.80
31%
-106
- C5 -
1SZF
2
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
-----------------
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
45
PsiBlast_CBE
83.54
31%
-103
- C5 -
1SZE
2
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F-----------------------
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
17
PsiBlast_PDB
83.25
31%
-107
- C5 -
1KBJ
2
CYB2_YEAST
A:
[20-376]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S-------------------
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
41
PsiBlast_CBE
82.51
31%
-102
- C5 -
1LDC
2
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
KF--------------------------------------------------------
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
48
PsiBlast_CBE
82.38
31%
-105
- C5 -
2OZ0
2
CYB2_YEAST
A:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
-----------------
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
Q
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------
47
PsiBlast_CBE
80.48
31%
-106
- C5 -
2OZ0
2
CYB2_YEAST
B:
[119-475]
------------------------------
L
D
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
GNP
L
E
G
-
E
K
D
V
A
R
G
C
G
Q
G
V
--
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
--
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
LKFS
N
-----------------
G
A
S
R
A
----------------------------
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
Q
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
N
L
-----
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
----------------