@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1928c: (2016-05-06 )
MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDALEKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGIDIAVCNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNSVSPGYILTELVEPYTEYQPLWEPKIPLGRLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP
Atome Classification :
(41 SA)
......-...10........20-.........30........40-.--..---...----...50.......-.-60.---...-.....--70........80........90.......-----.100........110.......120.......130....-...140.......150.......160.......170.......180.....--....190......----.-200.---.---.--.---.------------.-.210----.--.-.......220-.........230...-....240.......250...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
V
L
D
L
-FDLHG
K
R
A
L
I
TGAS--TGIG
K
R
V
A
L
A
Y
VEAG
A
Q
V
A
I
--
A
--
A
R
---
H
L
D
----
A
L
E
K
L
A
D
E
IGTS-G-G-
K
---
V
V
P
-
V
CCD
V
--
S
Q
H
Q
Q
V
T
S
M
L
D
Q
V
T
A
E
LG
G
I
D
I
A
V
CNA
G
I
-----
I
T
V-TPMLDM
P
L
E
E
F
Q
R
L
QNTNV
T
G
V
F
L
T
A
Q
A
A
A
K
A
M
V
K-QGQG
G
V
I
I
N
TASMS
G
H
I
INV
P
Q
Q
V
S
H
Y
C
ASK
A
A
V
I
H
L
T
K
A
M
A
V
E--LAP
H
K
--
I
R
VNSVSP
G
Y
I
L
T
----
E
-
L
V
E
P
---
Y
---T--E---Y------------Q-PL------W--E-PKIPLGRL---G
R
P
E
E
L
A
G
L
Y
L
Y
L
AS-E
A
S
SYMTGS
D
I
V
IDGGYTCP--
132
HHSearch
96.81
82%
-121
- C1 -
3R1I
2
?
A:
[23-276]
-
S
V
L
D
L
-
F
D
L
S
G
K
R
A
L
I
T
G
A
S
--
T
G
I
G
K
K
V
A
L
A
Y
A
E
A
G
A
Q
V
A
V
--
A
--
A
R
---
H
S
D
----
A
L
Q
V
V
A
D
E
I
A
G
V
-
G
-
G
-
K
---
A
L
P
-
I
R
C
D
V
--
T
Q
P
D
Q
V
R
G
M
L
D
Q
M
T
G
E
L
G
G
I
D
I
A
V
C
N
A
G
I
-----
V
S
V
-
Q
A
M
L
D
M
P
L
E
E
F
Q
R
I
Q
D
T
N
V
T
G
V
F
L
T
A
Q
A
A
A
R
A
M
V
D
-
Q
G
L
G
G
T
I
I
T
T
A
S
M
S
G
H
I
I
N
I
P
Q
Q
V
S
H
Y
C
T
S
K
A
A
V
V
H
L
T
K
A
M
A
V
E
--
L
A
P
H
Q
--
I
R
V
N
S
V
S
P
G
Y
I
R
T
----
E
-
L
V
E
P
---
L
---
A
--
D
---
Y
------------
H
-
A
L
------
W
--
E
-
P
K
I
P
L
G
R
M
---
G
R
P
E
E
L
T
G
L
Y
L
Y
L
A
S
-
A
A
S
S
Y
M
T
G
S
D
I
V
I
D
G
G
Y
T
C
P
--
1
PsiBlast_PDB
96.53
81%
-121
- C1 -
3R1I
2
?
A:
[23-276]
-
S
V
L
D
L
-
F
D
L
S
G
K
R
A
L
I
T
G
A
S
--
T
G
I
G
K
K
V
A
L
A
Y
A
E
A
G
A
Q
V
A
V
--
A
--
A
R
---
H
S
D
----
A
L
Q
V
V
A
D
E
I
A
G
V
-
G
-
G
-
K
---
A
L
P
-
I
R
C
D
V
--
T
Q
P
D
Q
V
R
G
M
L
D
Q
M
T
G
E
L
G
G
I
D
I
A
V
C
N
A
G
I
-----
V
S
V
-
Q
A
M
L
D
M
P
L
E
E
F
Q
R
I
Q
D
T
N
V
T
G
V
F
L
T
A
Q
A
A
A
R
A
M
V
D
-
Q
G
L
G
G
T
I
I
T
T
A
S
M
S
G
H
I
I
N
I
P
Q
Q
V
S
H
Y
C
T
S
K
A
A
V
V
H
L
T
K
A
M
A
V
E
--
L
A
P
H
Q
--
I
R
V
N
S
V
S
P
G
Y
I
R
T
----
E
-
L
V
E
P
---
L
---
A
--
D
---
Y
------------
H
-
A
L
------
W
--
E
-
P
K
I
P
L
G
R
M
---
G
R
P
E
E
L
T
G
L
Y
L
Y
L
A
S
-
A
A
S
S
Y
M
T
G
S
D
I
V
I
D
G
G
Y
T
C
P
--
21
PsiBlast_CBE
91.28
81%
-124
- C1 -
3R1I
1
?
B:
[22-276]
M
S
V
L
D
L
-
F
D
L
S
G
K
R
A
L
I
T
G
A
S
--
T
G
I
G
K
K
V
A
L
A
Y
A
E
A
G
A
Q
V
A
V
--
A
--
A
R
---
H
S
D
----
A
L
Q
V
V
A
D
E
I
A
G
V
-
G
-
G
-
K
---
A
L
P
-
I
R
C
D
V
--
T
Q
P
D
Q
V
R
G
M
L
D
Q
M
T
G
E
L
G
G
I
D
I
A
V
C
N
A
G
I
-----
V
S
V
-
Q
A
M
L
D
M
P
L
E
E
F
Q
R
I
Q
D
T
N
V
T
G
V
F
L
T
A
Q
A
A
A
R
A
M
V
D
-
Q
G
L
G
G
T
I
I
T
T
A
S
M
S
G
H
I
I
N
I
P
Q
Q
V
S
H
Y
C
T
S
K
A
A
V
V
H
L
T
K
A
M
A
V
E
--
L
A
P
H
Q
--
I
R
V
N
S
V
S
P
G
Y
I
R
T
------------------------
Y
------------
H
-
A
L
------
W
--
E
-
P
K
I
P
L
G
R
M
---
G
R
P
E
E
L
T
G
L
Y
L
Y
L
A
S
-
A
A
S
S
Y
M
T
G
S
D
I
V
I
D
G
G
Y
T
C
P
--
9
PsiBlast_PDB
78.32
38%
-114
- C1 -
4NPC
1
?
A:
[16-263]
---
I
D
L
N
F
P
L
S
E
K
V
A
I
V
T
G
G
A
--
S
G
I
G
A
A
I
S
K
A
F
I
A
K
G
A
K
V
A
V
--
L
--
D
I
---
S
A
D
----
I
A
K
A
K
A
E
E
L
G
E
N
---------
A
K
P
-
F
V
C
D
V
--
S
S
Q
Q
S
V
N
D
A
I
T
A
V
I
S
Q
F
G
K
I
D
I
A
V
N
S
A
G
V
-----
V
Y
L
-
A
P
A
E
D
I
S
L
D
Y
W
D
K
T
I
N
I
N
L
K
G
S
F
L
V
T
Q
A
V
G
R
A
M
I
A
-
A
G
N
G
G
K
I
I
N
L
A
S
Q
A
G
T
V
A
-
I
E
E
H
V
A
-
Y
C
A
S
K
F
G
V
I
G
M
S
K
T
F
A
A
E
--
W
G
K
Y
G
--
I
C
V
N
T
L
S
P
T
I
V
L
T
----
E
-
L
G
K
K
---
A
---
W
AG
E
---
K
------------
G
-
E
A
------
A
--
K
-
K
R
I
P
A
G
R
F
---
A
Y
P
E
E
I
A
A
A
A
V
F
L
A
S
-
A
G
A
D
M
I
T
G
A
D
L
L
I
D
G
G
Y
T
----
32
PsiBlast_CBE
77.75
38%
-114
- C1 -
4NPC
1
?
B:
[16-263]
---
I
D
L
N
F
P
L
S
E
K
V
A
I
V
T
G
G
A
--
S
G
I
G
A
A
I
S
K
A
F
I
A
K
G
A
K
V
A
V
--
L
--
D
I
---
S
A
D
----
I
A
K
A
K
A
E
E
L
G
E
N
---------
A
K
P
-
F
V
C
D
V
--
S
S
Q
Q
S
V
N
D
A
I
T
A
V
I
S
Q
F
G
K
I
D
I
A
V
N
S
A
G
V
-----
V
Y
L
-
A
P
A
E
D
I
S
L
D
Y
W
D
K
T
I
N
I
N
L
K
G
S
F
L
V
T
Q
A
V
G
R
A
M
I
A
-
A
G
N
G
G
K
I
I
N
L
A
S
Q
A
G
T
V
A
-
I
E
E
H
V
A
-
Y
C
A
S
K
F
G
V
I
G
M
S
K
T
F
A
A
E
--
W
G
K
Y
G
--
I
C
V
N
T
L
S
P
T
I
V
L
T
----
E
-
L
G
K
K
---
A
---
W
AG
E
---
K
------------
G
-
E
A
------
A
--
K
-
K
R
I
P
A
G
R
F
---
A
Y
P
E
E
I
A
A
A
A
V
F
L
A
S
-
A
G
A
D
M
I
T
G
A
D
L
L
I
D
G
G
Y
T
----
113
Fugue
76.85
35%
-121
- C1 -
1FMC
2
HDHA_ECOLI
A:
[1-255]
M
F
N
S
D
N
-
L
R
L
D
G
K
C
A
I
I
T
G
A
G
--
A
G
I
G
K
E
I
A
I
T
F
A
T
A
G
A
S
V
V
V
--
S
D
I-----
N
A
D
----
A
A
N
H
V
V
D
E
I
Q
Q
L
------G
G
Q
A
F
A
-
C
R
C
D
I
TS--
E
Q
E
L
S
A
L
A
D
F
A
I
S
K
L
G
K
V
D
I
L
V
N
N
A
G
G
G
G
P
KP
F
-
D
--
M
P
----
M
A
D
F
R
R
A
Y
E
L
N
V
F
S
F
F
H
L
S
Q
L
V
A
P
E
M
E
K
N
-
G
-
G
G
V
I
L
T
I
T
S
M
A
A
E
N
-
K
N
I
N
M
T
-
S
Y
A
S
S
K
A
A
A
S
H
L
V
R
N
M
A
F
---
D
L
G
E
-KN
I
R
V
N
G
I
A
P
G
A
I
L
T
----
D
-
A
L
K
S
V
IT
P
---
E
--
I
---
E
------------
Q
-
K
M
------
L
--
Q
--
H
T
P
I
--
R
R
L
G
-
Q
P
Q
D
I
A
N
A
A
L
F
L
C
S
P-
A
A
S
W
V
S
G
Q
I
L
T
V
S
G
G
G
V
Q
E
LN
8
PsiBlast_PDB
76.56
35%
-118
- C1 -
1VL8
2
?
A:
[17-266]
-------
F
D
L
R
G
R
V
A
L
V
T
G
G
S
--
R
G
L
G
F
G
I
A
Q
G
L
A
E
A
G
C
S
V
V
V
--
A
--
S
R
---
N
L
E
E
A
S
E
A
A
Q
K
L
T
E
K
Y
G
V
------
E
---
T
M
A
-
F
R
C
D
V
--
S
N
Y
E
E
V
K
K
L
L
E
A
V
K
E
K
F
G
K
L
D
T
V
V
N
A
A
G
I
-----
N
R
R
-
H
P
A
E
E
F
P
L
D
E
F
R
Q
V
I
E
V
N
L
F
G
T
Y
Y
V
C
R
E
A
F
-
S
L
L
R
-
E
S
D
N
P
S
I
I
N
I
G
S
L
T
V
E
E
V
T
M
P
N
-
I
S
A
Y
A
A
S
K
G
G
V
A
S
L
T
K
A
L
A
K
E
--
W
G
R
Y
G
--
I
R
V
N
V
I
A
P
G
W
Y
R
T
----
K
-
M
T
E
A
V
--
F
---
S
--
D
---
P
------------
E
-
K
L
D
Y
----
M
--
L
-
K
R
I
P
L
G
R
T
---
G
V
P
E
D
L
K
G
V
A
V
F
L
A
S
-
E
E
A
K
Y
V
T
G
Q
I
I
F
V
D
G
G
W
T
A
---
142
HHSearch
76.55
36%
-106
- C1 -
3AWD
-
?
A:
[5-258]
--
Y
M
E
K
-
L
R
L
D
N
R
V
A
I
V
T
G
G
A
--
Q
N
I
G
L
A
C
V
T
A
L
A
E
A
G
A
R
V
I
I
--
A
--
D
L
---
D
E
A
----
M
A
T
K
A
V
E
D
L
R
M
E
-
G
-
H
-
D
---
V
S
S
-
V
V
M
D
V
--
T
N
T
E
S
V
Q
N
A
V
R
S
V
H
E
Q
E
G
R
V
D
I
L
V
A
C
A
G
I
-----
C
I
S
E
V
K
A
E
D
M
T
D
G
Q
W
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
L
E
-
Q
K
-
Q
G
V
I
V
A
I
G
S
M
S
G
L
I
V
N
R
P
Q
Q
Q
A
A
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
--
W
A
P
H
G
--
I
R
A
N
A
V
A
P
T
Y
I
E
T
----
T
-
L
T
R
F
---
G
M
E
K
P
--
E
---
L
------------
Y
-
D
A
------
W
--
I
-
A
G
T
P
M
G
R
V
---
G
Q
P
D
E
V
A
S
V
V
Q
F
L
A
S
-
D
A
A
S
L
M
T
G
A
I
V
N
V
D
A
G
F
T
----
31
PsiBlast_CBE
76.35
35%
-118
- C1 -
1VL8
3
?
B:
[16-266]
-----
V
-
F
D
L
R
G
R
V
A
L
V
T
G
G
S
--
R
G
L
G
F
G
I
A
Q
G
L
A
E
A
G
C
S
V
V
V
--
A
--
S
R
---
N
L
E
E
A
S
E
A
A
Q
K
L
T
E
K
Y
G
V
------
E
---
T
M
A
-
F
R
C
D
V
--
S
N
Y
E
E
V
K
K
L
L
E
A
V
K
E
K
F
G
K
L
D
T
V
V
N
A
A
G
I
-----
N
R
R
-
H
P
A
E
E
F
P
L
D
E
F
R
Q
V
I
E
V
N
L
F
G
T
Y
Y
V
C
R
E
A
F
-
S
L
L
R
-
E
S
D
N
P
S
I
I
N
I
G
S
L
T
V
E
E
V
T
M
P
N
-
I
S
A
Y
A
A
S
K
G
G
V
A
S
L
T
K
A
L
A
K
E
--
W
G
R
Y
G
--
I
R
V
N
V
I
A
P
G
W
Y
R
T
----
K
-
M
T
E
A
V
--
F
---
S
--
D
---
P
------------
E
-
K
L
D
Y
----
M
--
L
-
K
R
I
P
L
G
R
T
---
G
V
P
E
D
L
K
G
V
A
V
F
L
A
S
-
E
E
A
K
Y
V
T
G
Q
I
I
F
V
D
G
G
W
T
A
---
130
HHSearch
74.52
37%
-114
- C1 -
3WDS
4
?
A:
[7-261]
-----
I
-
F
D
L
S
G
R
K
A
I
V
T
G
G
S
--
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
--
A
--
D
L
---
D
V
M
----
A
A
Q
A
V
V
A
G
L
E
-----
N
-
G
---
G
F
A
-
V
E
V
D
V
--
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
-----
S
T
M
-
R
P
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
-
S
N
T
K
G
V
I
V
N
T
A
S
L
A
A
K
V
G
A
P
--
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
--
M
A
P
K
N
--
I
R
V
N
C
V
C
P
G
F
V
K
T
----
A
-
M
Q
E
R
---
E
---
I
--
I
---
W
E
A
E
L
R
GMT
P
E
A
V
R
-
A
E
------
Y
--
V
-
S
L
T
P
L
G
R
I
---
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
-
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
V
R
----
103
PsiBlast_CBE
74.35
36%
-111
- C1 -
4RF3
3
?
B:
[25-271]
---------
L
K
G
K
V
A
I
V
T
G
G
T
--
L
G
I
G
L
A
I
A
D
K
F
V
E
E
G
A
K
V
V
I
--
T
--
G
R
---
H
A
D
----
V
G
E
K
A
A
K
S
I
G
---
G
-
T
-
D
---
V
I
R
F
V
Q
H
D
A
--
S
D
E
A
G
W
T
K
L
F
D
T
T
E
E
A
F
G
P
V
T
T
V
V
N
N
A
G
I
-----
F
V
S
-
K
S
V
E
D
T
T
T
E
E
W
R
K
L
L
S
V
N
L
D
G
V
F
F
G
T
R
L
G
I
Q
R
M
K
N
-
K
G
L
G
A
S
I
I
N
M
S
S
I
E
G
F
V
G
D
--
P
T
L
G
A
Y
N
A
S
K
G
A
V
R
I
M
S
K
S
A
A
L
D
C
A
L
K
D
Y
D
--
V
R
V
N
T
V
H
P
G
Y
I
K
T
----
P
-
L
V
D
D
---
L
---
E
--
G
---
A
------------
E
-
E
M
------
M
S
Q
R
-
T
K
T
P
M
G
H
I
---
G
E
P
N
D
I
A
W
I
C
V
Y
L
A
S
-
D
E
S
K
F
A
T
G
A
E
F
V
V
D
G
G
Y
T
A
---
74
PsiBlast_CBE
74.25
36%
-111
- C1 -
4G81
1
?
C:
[4-251]
-----
L
-
F
D
L
T
G
K
T
A
L
V
T
G
S
A
--
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
--
N
--
D
I
---
R
A
T
----
L
L
A
E
S
V
D
T
L
T
R
K
-
G
-
Y
-
D
---
A
H
G
-
V
A
F
D
V
--
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
-----
Q
Y
R
-
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
-
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
--
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
--
W
A
Q
F
N
--
I
Q
T
N
A
I
G
P
G
Y
I
L
T
----
D
-
M
N
T
A
---
L
---
I
--
E
---
D
------------
K
-
Q
F
DS----
W
V-
K
-
S
S
T
P
S
Q
R
W
---
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
-
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
-----
124
HHSearch
73.84
36%
-107
- C1 -
4G81
2
?
D:
[3-252]
----
A
L
-
F
D
L
T
G
K
T
A
L
V
T
G
S
A
--
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
--
N
--
D
I
---
R
A
T
----
L
L
A
E
S
V
D
T
L
T
R
K
-
G
-
Y
-
D
---
A
H
G
-
V
A
F
D
V
--
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
-----
Q
Y
R
-
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
-
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
--
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
--
W
A
Q
F
N
--
I
Q
T
N
A
I
G
P
G
Y
I
L
T
----
D
-
M
N
T
A
---
L
---
I
E-
D
KQ-
F
------------
D
-
S
W
------
V
--
K
-
S
S
T
P
S
Q
R
W
---
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
-
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
----
100
PsiBlast_CBE
73.75
36%
-105
- C1 -
2PNF
3
FABG_AQUAE
A:
[5-246]
---------
L
Q
G
K
V
S
L
V
T
G
S
T
--
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
--
T
--
G
T
---
S
G
E
----
R
A
K
A
V
A
E
E
I
A
N
K
-
Y
-
G
V
K
---
A
H
G
-
V
E
M
N
L
--
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
G
I
D
I
L
V
N
N
A
G
I
-----
T
R
D
-
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
-
Q
-
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
--
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
--
L
A
P
R
N
--
V
L
V
N
A
V
A
P
G
F
I
E
T
----
D
-
M
T
A
V
---
L
---
S
--
E
E
--
I
------------
K
-
Q
K
------
Y
--
K
-
E
Q
I
P
L
G
R
F
---
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
-
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
G
------
111
PsiBlast_CBE
73.74
36%
-109
- C1 -
4RF2
1
?
B:
[25-271]
---------
L
K
G
K
V
A
I
V
T
G
G
T
--
L
G
I
G
L
A
I
A
D
K
F
V
E
E
G
A
K
V
V
I
--
T
--
G
R
---
H
A
D
----
V
G
E
K
A
A
K
S
I
G
---
G
-
T
-
D
---
V
I
R
F
V
Q
H
D
A
--
S
D
E
A
G
W
T
K
L
F
D
T
T
E
E
A
F
G
P
V
T
T
V
V
N
N
A
G
I
-----
A
V
S
-
K
S
V
E
D
T
T
T
E
E
W
R
K
L
L
S
V
N
L
D
G
V
F
F
G
T
R
L
G
I
Q
R
M
K
N
-
K
G
L
G
A
S
I
I
N
M
S
S
I
E
G
F
V
G
D
--
P
T
L
G
A
Y
N
A
S
K
G
A
V
R
I
M
S
K
S
A
A
L
D
CA
L
K
D
Y
D
--
V
R
V
N
T
V
H
P
G
Y
I
K
T
----
P
-
L
V
D
D
---
L
---
E
--
G
---
A
------------
E
-
E
M
------
M
SQ
R
-
T
K
T
P
M
G
H
I
---
G
E
P
N
D
I
A
W
I
C
V
Y
L
A
S
-
D
E
S
K
F
A
T
G
A
E
F
V
V
D
G
G
Y
T
A
---
46
PsiBlast_CBE
73.33
41%
-106
- C1 -
1GEG
2
BUDC_KLEPN
D:
[3-252]
------------
K
V
A
L
V
T
G
A
G
--
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
--
A
--
D
Y
---
N
D
A
----
T
A
K
A
V
A
S
E
I
N
Q
A
-
G
-
G
-
H
---
A
V
A
-
V
K
V
D
V
--
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
-
T
P
I
E
S
I
T
P
E
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
-
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
--
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
--
L
A
P
L
G
--
I
T
V
N
G
Y
C
P
G
I
V
K
T
PMWA
E
-
I
D
R
Q
---
V
---
S
--
E
---
A
AG----------
K
-
P
L
GYGTAE
F
--
A
-
K
R
I
T
L
G
R
L
---
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
-
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
------
73
PsiBlast_CBE
73.16
36%
-108
- C1 -
4G81
2
?
D:
[4-251]
-----
L
-
F
D
L
T
G
K
T
A
L
V
T
G
S
A
--
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
--
N
--
D
I
---
R
A
T
----
L
L
A
E
S
V
D
T
L
T
R
K
-
G
-
Y
-
D
---
A
H
G
-
V
A
F
D
V
--
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
-----
Q
Y
R
-
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
-
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
--
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
--
W
A
Q
F
N
--
I
Q
T
N
A
I
G
P
G
Y
I
L
T
----
D
-
M
N
T
A
---
L
---
I
--
E
---
D
------------
K
-
Q
F
DS----
W
V-
K
-
S
S
T
P
S
Q
R
W
---
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
-
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
-----
6
PsiBlast_PDB
73.08
38%
-103
- C1 -
4J2H
7
?
A:
[7-253]
-----
I
-
F
D
L
S
G
R
R
A
L
V
T
G
A
S
--
R
G
I
G
Q
S
I
A
V
A
L
A
E
A
G
A
H
V
A
V
--
T
--
A
R
---
T
V
E
----
G
L
A
E
T
R
A
L
I
E
K
T
-
G
-
R
-
R
---
A
V
A
-
L
A
Q
D
V
--
R
D
V
E
A
C
A
S
V
T
R
A
A
A
E
G
L
G
G
L
D
I
L
V
N
N
A
G
F
-----
E
N
V
-
R
P
S
F
D
V
D
E
A
L
W
D
T
I
V
S
T
N
L
K
G
A
F
F
C
A
Q
A
A
G
R
-
I
M
A
-
D
A
N
G
G
A
I
V
N
L
C
S
L
T
S
Y
-
V
G
I
P
T
A
V
P
-
Y
G
A
S
K
S
G
L
L
G
V
T
R
A
L
A
T
E
--
W
A
A
H
N
--
I
R
V
N
A
I
A
P
G
Y
F
R
T
----
A
-
M
T
A
G
---
F
---
Y
--
E
D
E
D
W
------------
Q
-
S
R
------
M
--
L
-
E
K
I
P
Q
R
R
F
---
G
K
E
S
D
I
G
G
V
A
V
F
L
C
S
-
D
A
A
A
Y
I
T
G
H
C
I
P
A
D
G
G
Y
-----
76
PsiBlast_CBE
73.07
36%
-109
- C1 -
4G81
1
?
A:
[4-251]
-----
L
-
F
D
L
T
G
K
T
A
L
V
T
G
S
A
--
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
--
N
--
D
I
---
R
A
T
----
L
L
A
E
S
V
D
T
L
T
R
K
-
G
-
Y
-
D
---
A
H
G
-
V
A
F
D
V
--
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
-----
Q
Y
R
-
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
-
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
--
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
--
W
A
Q
F
N
--
I
Q
T
N
A
I
G
P
G
Y
I
L
T
----
D
-
M
N
T
A
---
L
---
I
--
E
---
D
------------
K
-
Q
F
D
S
----
W
V
-
K
-
S
S
T
P
S
Q
R
W
---
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
-
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
-----
5
PsiBlast_PDB
73.02
40%
-101
- C1 -
3GDG
-
MTDH_DAVTA
A:
[11-265]
-
S
L
L
D
Q
-
L
S
L
K
G
K
V
V
V
V
T
G
A
S
GP
K
G
M
G
I
E
A
A
R
G
C
A
E
M
G
A
A
V
A
I
T
Y
A
--
S
R
---
A
Q
G
----
A
E
E
N
V
K
E
L
E
K
T
Y
-
G
-
I
-
K
---
A
K
A
-
Y
K
C
Q
V
--
D
S
Y
E
S
C
E
K
L
V
K
D
V
V
A
D
F
G
Q
I
D
A
F
I
A
N
A
G
A
-----
T
A
D
-
S
G
I
L
D
G
S
V
E
A
W
N
H
V
V
Q
V
D
L
N
G
T
F
H
C
A
K
A
V
G
H
H
F
K
E
-
R
G
T
G
S
L
V
I
-
T
A
S
M
S
G
H
I
A
N
F
P
Q
E
Q
T
S
Y
N
V
A
K
A
G
C
I
H
M
A
R
S
L
A
N
E
--
W
R
D
F
---
A
R
V
N
S
I
S
P
G
Y
I
D
T
----
G
-
L
S
D
F
---
V
P--
K
--
E
---
T
------------
Q
-
Q
L
------
W
--
H
-
S
M
I
P
M
G
R
D
---
G
L
A
K
E
L
K
G
A
Y
V
Y
F
A
S
-
D
A
S
T
Y
T
T
G
A
D
L
L
I
D
G
G
Y
T
----
19
PsiBlast_PDB
70.19
36%
-99
- C1 -
2WSB
3
?
A:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
F
E
T
---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
58
PsiBlast_CBE
69.43
36%
-100
- C1 -
2WSB
3
?
C:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
60
PsiBlast_CBE
69.26
36%
-102
- C1 -
2WDZ
3
?
D:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
22
PsiBlast_CBE
68.95
38%
-97
- C1 -
3PK0
4
?
D:
[5-254]
-----
M
-
F
D
L
Q
G
R
S
V
V
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
G
R
STA
D
I
D
----
A
C
V
A
D
L
D
Q
L
G
S
----
G
-
K
---
V
I
G
-
V
Q
T
D
V
--
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
V
-----
F
P
D
-
A
P
L
A
T
M
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
-
S
G
S
G
R
V
V
L
-
T
S
S
I
T
G
P
I
T
G
Y
P
G
W
-
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
H
K
--
I
T
V
N
A
I
M
P
G
N
I
M
T
----
E
G
L
L
E
N
---
G
---
E
--
E
---
Y
------------
I
-
A
S
------
M
--
A
-
R
S
I
P
A
G
A
L
---
G
T
P
E
D
I
G
H
L
A
A
F
L
A
T
-
K
E
A
G
Y
I
T
G
Q
A
I
A
V
D
G
G
Q
V
L
P
--
96
PsiBlast_CBE
68.88
37%
-105
- C1 -
3RIH
10
?
A:
[36-285]
-----
M
-
F
D
L
S
A
R
S
V
L
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
A
R
---
S
P
R
----
E
L
S
S
V
T
A
E
L
G
E
L
-
G
A
G
-
N
---
V
I
G
-
V
R
L
D
V
--
S
D
P
G
S
C
A
D
A
A
R
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
I
-----
F
P
E
-
A
R
L
D
T
M
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
-
S
G
R
G
R
V
I
L
-
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
-
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
R
G
--
V
T
V
N
A
I
L
P
G
N
I
L
T
----
E
G
L
V
D
M
---
G
---
E
--
E
---
Y
------------
I
-
S
G
------
M
--
A
-
R
S
I
P
M
G
M
L
---
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
-
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
--
62
PsiBlast_CBE
68.70
36%
-99
- C1 -
2WDZ
2
?
B:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
94
PsiBlast_CBE
68.64
37%
-105
- C1 -
3RIH
7
?
C:
[36-285]
-----
M
-
F
D
L
S
A
R
S
V
L
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
A
R
---
S
P
R
----
E
L
S
S
V
T
A
E
L
G
E
L
-
G
A
G
-
N
---
V
I
G
-
V
R
L
D
V
--
S
D
P
G
S
C
A
D
A
A
R
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
I
-----
F
P
E
-
A
R
L
D
T
M
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
-
S
G
R
G
R
V
I
L
-
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
-
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
R
G
--
V
T
V
N
A
I
L
P
G
N
I
L
T
----
E
G
L
V
D
M
---
G
---
E
--
E
---
Y
------------
I
-
S
G
------
M
--
A
-
R
S
I
P
M
G
M
L
---
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
-
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
--
3
PsiBlast_PDB
68.47
38%
-97
- C1 -
3PK0
5
?
A:
[5-254]
-----
M
-
F
D
L
Q
G
R
S
V
V
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
G
R
S
T
A
D
I
D
----
A
C
V
A
D
L
D
Q
L
G
S
----
G
-
K
---
V
I
G
-
V
Q
T
D
V
--
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
V
-----
F
P
D
-
A
P
L
A
T
M
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
-
S
G
S
G
R
V
V
L
-
T
S
S
I
T
G
P
I
T
G
Y
P
G
W
-
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
H
K
--
I
T
V
N
A
I
M
P
G
N
I
M
T
----
E
G
L
L
E
N
---
G
---
E
--
E
---
Y
------------
I
-
A
S
------
M
--
A
-
R
S
I
P
A
G
A
L
---
G
T
P
E
D
I
G
H
L
A
A
F
L
A
T
-
K
E
A
G
Y
I
T
G
Q
A
I
A
V
D
G
G
Q
V
L
P
--
95
PsiBlast_CBE
68.43
37%
-104
- C1 -
3RIH
11
?
B:
[36-285]
-----
M
-
F
D
L
S
A
R
S
V
L
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
A
R
---
S
P
R
----
E
L
S
S
V
T
A
E
L
G
E
L
-
G
A
G
-
N
---
V
I
G
-
V
R
L
D
V
--
S
D
P
G
S
C
A
D
A
A
R
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
I
-----
F
P
E
-
A
R
L
D
T
M
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
-
S
G
R
G
R
V
I
L
-
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
-
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
R
G
--
V
T
V
N
A
I
L
P
G
N
I
L
T
----
E
G
L
V
D
M
---
G
---
E
--
E
---
Y
------------
I
-
S
G
------
M
--
A
-
R
S
I
P
M
G
M
L
---
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
-
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
--
93
PsiBlast_CBE
68.35
37%
-104
- C1 -
3RIH
5
?
D:
[36-285]
-----
M
-
F
D
L
S
A
R
S
V
L
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
A
R
---
S
P
R
----
E
L
S
S
V
T
A
E
L
G
E
L
-
G
A
G
-
N
---
V
I
G
-
V
R
L
D
V
--
S
D
P
G
S
C
A
D
A
A
R
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
I
-----
F
P
E
-
A
R
L
D
T
M
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
-
S
G
R
G
R
V
I
L
-
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
-
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
R
G
--
V
T
V
N
A
I
L
P
G
N
I
L
T
----
E
G
L
V
D
M
---
G
---
E
--
E
---
Y
------------
I
-
S
G
------
M
--
A
-
R
S
I
P
M
G
M
L
---
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
-
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
--
59
PsiBlast_CBE
68.27
36%
-99
- C1 -
2WSB
3
?
B:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
57
PsiBlast_CBE
68.02
36%
-99
- C1 -
2WSB
3
?
D:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
61
PsiBlast_CBE
67.82
36%
-96
- C1 -
2WDZ
2
?
C:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
54
PsiBlast_CBE
67.63
36%
-96
- C1 -
3LQF
2
?
D:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
FET---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----
23
PsiBlast_CBE
67.57
38%
-98
- C1 -
3PK0
4
?
C:
[5-254]
-----
M
-
F
D
L
Q
G
R
S
V
V
V
T
G
G
T
--
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
--
A
--
G
R
S
T
A
D
I
D
----
A
C
V
A
D
L
D
Q
L
G
S
----
G
-
K
---
V
I
G
-
V
Q
T
D
V
--
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
V
-----
F
P
D
-
A
P
L
A
T
M
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
-
S
G
S
G
R
V
V
L
-
T
S
S
I
T
G
P
I
T
G
Y
P
G
W
-
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
--
L
A
P
H
K
--
I
T
V
N
A
I
M
P
G
N
I
M
T
----
E
G
L
L
E
N
---
G
---
E
--
E
---
Y
------------
I
-
A
S
------
M
--
A
-
R
S
I
P
A
G
A
L
---
G
T
P
E
D
I
G
H
L
A
A
F
L
A
T
-
K
E
A
G
Y
I
T
G
Q
A
I
A
V
D
G
G
Q
V
L
P
--
12
PsiBlast_PDB
67.17
40%
-102
- C1 -
4NBU
1
?
A:
[11-247]
---------
L
Q
D
K
V
A
I
I
T
G
A
A
--
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
--
A
---------
D
----
F
N
E
A
A
G
K
E
A
V
E
A
-
N
-
P
-
G
---
V
V
F
-
I
R
V
D
V
--
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
-----
T
R
D
-
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
-
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
--
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
----
A
-
M
V
A
E
---
V
---
P
--
E
---
K
------------
V
I
E
K
------
M
--
K
-
A
Q
V
P
M
G
R
L
---
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
------
40
PsiBlast_CBE
66.90
40%
-101
- C1 -
4NBU
1
?
C:
[11-247]
---------
L
Q
D
K
V
A
I
I
T
G
A
A
--
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
--
A
---------
D
----
F
N
E
A
A
G
K
E
A
V
E
A
-
N
-
P
-
G
---
V
V
F
-
I
R
V
D
V
--
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
-----
T
R
D
-
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
-
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
--
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
----
A
-
M
V
A
E
---
V
---
P
--
E
---
K
------------
V
I
E
K
------
M
--
K
-
A
Q
V
P
M
G
R
L
---
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
------
64
PsiBlast_CBE
66.61
36%
-104
- C1 -
4I08
6
FABG_VIBCH
A:
[7-247]
-----
F
-
M
N
L
E
G
K
V
A
L
V
T
G
A
S
--
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
--
T
--
A
T
---
S
E
S
----
G
A
Q
A
I
S
D
Y
L
G
D
N
-
G
--------
K
G
-
M
A
L
N
V
--
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
-----
T
R
D
-
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
-
K
R
Q
-
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
--
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
--
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
----
D
-
M
----------
N
--
D
---
E
------------
Q
-
R
T
------
A
--
T
L
A
Q
V
P
A
G
R
L
---
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
-
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
------
41
PsiBlast_CBE
66.16
40%
-101
- C1 -
4NBU
2
?
B:
[11-247]
---------
L
Q
D
K
V
A
I
I
T
G
A
A
--
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
--
A
---------
D
----
F
N
E
A
A
G
K
E
A
V
E
A
-
N
-
P
-
G
---
V
V
F
-
I
R
V
D
V
--
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
-----
T
R
D
-
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
-
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
--
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
----
A
-
M
V
A
E
---
V
---
P
--
E
---
K
------------
V
I
E
K
------
M
--
K
-
A
Q
V
P
M
G
R
L
---
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
------
39
PsiBlast_CBE
66.10
40%
-101
- C1 -
4NBU
2
?
D:
[11-247]
---------
L
Q
D
K
V
A
I
I
T
G
A
A
--
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
--
A
---------
D
----
F
N
E
A
A
G
K
E
A
V
E
A
-
N
-
P
-
G
---
V
V
F
-
I
R
V
D
V
--
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
-----
T
R
D
-
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
-
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
--
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
----
A
-
M
V
A
E
---
V
---
P
--
E
---
K
------------
V
I
E
K
------
M
--
K
-
A
Q
V
P
M
G
R
L
---
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
-
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
------
17
PsiBlast_PDB
65.70
36%
-97
- C1 -
2WDZ
3
?
A:
[1-252]
M
D
Y
R
T
V
-
F
R
L
D
G
A
C
A
A
V
T
G
A
G
--
S
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
I
L
--
I
--
D
R
---
E
A
A
----
A
L
D
R
A
A
Q
E
L
G
A
A
V
A
-
A
-
R
---
I
V
A
-
D
V
T
D
A
--
E
A
M
T
A
A
A
A
E
A
E
A
V
A
P
----
V
S
I
L
V
N
S
A
G
I
-----
A
R
L
-
H
D
A
L
E
T
D
D
A
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
S
R
A
F
G
R
A
M
V
A
-
R
G
-
A
G
A
I
V
N
L
G
S
M
S
G
T
I
V
N
R
P
Q
F
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
--
W
A
G
R
G
--
V
R
V
N
A
L
A
P
G
Y
V
A
T
----
E
-
M
T
L
K
---
M
---
R
--
E
---
R
------------
P
-
E
L
F
E
T
---
W
--
L
-
D
M
T
P
M
G
R
C
---
G
E
P
S
E
I
A
A
A
A
L
F
L
A
S
-
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
----