@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1938: (2016-05-06 )
MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP
Atome Classification :
(45 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60........70.--.......80........90...--.....100.......110.......120.......130.......140.......150.......160.-......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
Q
V
H
R
I
L
NCRG
T
R
I
H
A
VADSPPDQQG
P
L
V
V
L
L
HGF
P
E
S
W
Y
S
W
R
HQIPALAGA
G
Y
R
V
V
A
I
DQRGYGRSS
K
Y
R
--
V
Q
K
A
Y
R
I
K
E
L
V
G
D
V
V
G
V
L
D
SYG--AE
Q
A
F
V
V
GHDWGA
P
V
A
W
T
F
A
WL
H
P
D
RCA
G
V
V
G
ISVPFAGRGVIGLPGSPFGERRPS
D
Y
H
L
E
LAGPG
R
V
W
-
Y
Q
D
Y
F
A
VQD
G
I
I
T
E
I
E
E
D
L
R
G
W
L
L
G
L
T
Y
T
VSGEG
M
M
A
A
T
K
A
AVDAGVDLESMDP
I
D
VIRAGPLCMAEGARLK
D
A
F
VYPETMP
A
W
FTEADLDFYTGEFERSGFGG
P
L
S
F
Y
HNIDN
D
W
H
D
L
A
DQQGKPLTP
P
A
L
F
IGGQYD
V
G
T
I
W
G
A
Q
A
I
E
R
A
H
E
VMPNYRGT
H
M
I
A
D
V
G
H
W
I
Q
Q
EAP
E
E
T
N
R
L
L
L
D
F
LGGLRP
2
PsiBlast_PDB
92.02
99%
-113
- C1 -
2E3J
9
?
A:
[4-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
R
I
L
N
C
R
G
T
R
I
H
A
V
A
D
S
P
P
D
Q
Q
G
P
L
V
V
L
L
H
G
F
P
E
S
W
Y
S
W
R
H
Q
I
P
A
L
A
G
A
G
Y
R
V
V
A
I
D
Q
R
G
Y
G
R
S
S
K
Y
R
--
V
Q
K
A
Y
R
I
K
E
L
V
G
D
V
V
G
V
L
D
S
Y
G
--
A
E
Q
A
F
V
V
G
H
D
W
G
A
P
V
A
W
T
F
A
W
L
H
P
D
R
C
A
G
V
V
G
I
S
V
P
F
A
G
R
G
V
I
G
L
P
G
S
P
F
G
E
R
R
P
S
D
Y
H
L
E
L
A
G
P
G
R
V
W
-
Y
Q
D
Y
F
A
V
Q
D
G
I
I
T
E
I
E
E
D
L
R
G
W
L
L
G
L
T
Y
T
V
S
G
E
G
M
M
A
A
T
K
A
A
V
-------
S
M
D
P
I
D
V
I
R
A
G
P
L
C
M
A
E
G
A
R
L
K
D
A
F
V
Y
P
E
T
M
P
A
W
F
T
E
A
D
L
D
F
Y
T
G
E
F
E
R
S
G
F
G
G
P
L
S
F
Y
H
N
I
D
N
D
W
H
D
L
A
D
Q
Q
G
K
P
L
T
P
P
A
L
F
I
G
G
Q
Y
D
V
G
T
I
W
G
A
Q
A
I
E
R
A
H
E
V
M
P
N
Y
R
G
T
H
M
I
A
D
V
G
H
W
I
Q
Q
E
A
P
E
E
T
N
R
L
L
L
D
F
L
G
G
L
R
P
1
PsiBlast_PDB
91.98
99%
-114
- C1 -
2ZJF
4
?
A:
[10-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
R
I
L
N
C
R
G
T
R
I
H
A
V
A
D
S
P
P
D
Q
Q
G
P
L
V
V
L
L
H
G
F
P
E
S
W
Y
S
W
R
H
Q
I
P
A
L
A
G
A
G
Y
R
V
V
A
I
D
Q
R
G
Y
G
R
S
S
K
Y
R
--
V
Q
K
A
Y
R
I
K
E
L
V
G
D
V
V
G
V
L
D
S
Y
G
--
A
E
Q
A
F
V
V
G
H
D
W
G
A
P
V
A
W
T
F
A
W
L
H
P
D
R
C
A
G
V
V
G
I
S
V
P
F
A
G
R
G
V
I
G
L
P
G
S
P
F
G
E
R
R
P
S
D
Y
H
L
E
L
A
G
P
G
R
V
W
-
Y
Q
D
Y
F
A
V
Q
D
G
I
I
T
E
I
E
E
D
L
R
G
W
L
L
G
L
T
Y
T
V
S
G
E
G
M
M
A
A
T
K
A
A
V
-------
S
M
D
P
I
D
V
I
R
A
G
P
L
C
M
A
E
G
A
R
L
K
D
A
F
V
Y
P
E
T
M
P
A
W
F
T
E
A
D
L
D
F
Y
T
G
E
F
E
R
S
G
F
G
G
P
L
S
F
Y
H
N
I
D
N
D
W
H
D
L
A
D
Q
Q
G
K
P
L
T
P
P
A
L
F
I
G
G
Q
Y
D
V
G
T
I
W
G
A
Q
A
I
E
R
A
H
E
V
M
P
N
Y
R
G
T
H
M
I
A
D
V
G
H
W
I
Q
Q
E
A
P
E
E
T
N
R
L
L
L
D
F
L
G
G
L
R
P
102
Fugue
60.20
30%
-101
* C1 *
1EK1
1
HYES_MOUSE
A:
[4-544]
R
V
A
A
F
D
LDGVLALPSIGPTEQLMKGKITFSQWVPLQIFSQAMAARSIN
R
P
M
L
Q
A
A
I
A
L
K
K
K
G
F
T
T
C
I
VTN
N
W
L
D
DGDK
R
D
S
L
A
Q
M
M
C
E
L
SQHFD
F
L
I
E
SCQVGMIKPEP
Q
I
Y
N
F
L
L
D
T
LKAKPNE
V
V
F
L
D
DFGSNL
K
P
A
R
D
M
GMV
T
I
L
V
HNTASALRELEKVTG
T
Q
F
P
E
APLP
V
P
C
N
PN
D
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
F
V
E
M
G
S
----
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
P
--
E
I
E
E
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
--
I
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
M
P
P
D
------------
P
D
V
S
P
M
K
V
I
R
S
I
P
V
F
N
-
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
S
F
F
R
A
S
D
E
T
G
F
I
A
V
H
K
A
T
E
I
G
G
I
L
V
N
T
P
E
D
P
N
------------------------
L
S
K
I
T
T
E
E
E
I
E
F
Y
I
Q
Q
F
K
K
T
G
F
R
G
P
L
N
W
Y
R
N
T
E
R
N
W
K
W
S
C
K
G
L
G
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
--
I
V
L
R
P
E
M
S
K
N
M
E
K
W
I
P
F
L
-
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
N
Q
I
L
I
K
W
L
Q
T
E
--
11
PsiBlast_PDB
60.00
32%
-105
- C1 -
1VJ5
2
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
70
PsiBlast_CBE
59.79
32%
-106
- C1 -
5ALO
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
69
PsiBlast_CBE
59.76
32%
-106
- C1 -
5ALP
6
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
83
PsiBlast_CBE
59.68
32%
-104
- C1 -
5AKY
4
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
27
PsiBlast_CBE
59.65
32%
-107
- C1 -
4Y2Y
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
80
PsiBlast_CBE
59.64
32%
-106
- C1 -
5ALE
4
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
79
PsiBlast_CBE
59.64
32%
-106
- C1 -
5ALF
1
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
46
PsiBlast_CBE
59.64
32%
-107
- C1 -
3WK8
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
100
PsiBlast_CBE
59.63
32%
-106
- C1 -
5AI8
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
42
PsiBlast_CBE
59.63
32%
-108
- C1 -
3WKC
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
96
PsiBlast_CBE
59.59
32%
-105
- C1 -
5AIC
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
99
PsiBlast_CBE
59.50
32%
-105
- C1 -
5AI9
2
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
55
PsiBlast_CBE
59.50
32%
-108
- C1 -
5AM4
6
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
54
PsiBlast_CBE
59.46
32%
-105
- C1 -
5AM5
4
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
48
PsiBlast_CBE
59.38
32%
-108
- C1 -
3WK6
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
44
PsiBlast_CBE
59.38
32%
-107
- C1 -
3WKA
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
10
PsiBlast_PDB
59.36
32%
-102
- C1 -
1S8O
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
82
PsiBlast_CBE
59.26
32%
-106
- C1 -
5AKZ
6
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
68
PsiBlast_CBE
59.23
32%
-106
- C1 -
5ALQ
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
45
PsiBlast_CBE
59.17
32%
-104
- C1 -
3WK9
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
34
PsiBlast_CBE
59.15
32%
-104
- C1 -
4Y2Q
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
89
PsiBlast_CBE
59.09
32%
-105
- C1 -
5AKH
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
84
PsiBlast_CBE
59.04
32%
-106
- C1 -
5AKX
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
47
PsiBlast_CBE
59.04
32%
-105
- C1 -
3WK7
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
66
PsiBlast_CBE
59.01
32%
-106
- C1 -
5ALT
6
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
33
PsiBlast_CBE
58.96
32%
-105
- C1 -
4Y2R
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
9
PsiBlast_PDB
58.88
32%
-107
- C1 -
4C4Z
1
HYES_HUMAN
A:
[29-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
74
PsiBlast_CBE
58.72
32%
-105
- C1 -
5ALK
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
4
PsiBlast_PDB
58.64
32%
-108
- C1 -
3ANT
1
HYES_HUMAN
A:
[39-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
73
PsiBlast_CBE
58.63
32%
-105
- C1 -
5ALL
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
49
PsiBlast_CBE
58.52
32%
-106
- C1 -
3WK5
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
51
PsiBlast_CBE
58.43
32%
-103
- C1 -
3PDC
1
HYES_HUMAN
B:
[54-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
97
PsiBlast_CBE
58.39
32%
-106
- C1 -
5AIB
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
72
PsiBlast_CBE
58.30
32%
-105
- C1 -
5ALM
3
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
35
PsiBlast_CBE
58.24
32%
-105
- C1 -
4Y2P
1
HYES_HUMAN
A:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
7
PsiBlast_PDB
58.06
32%
-104
- C1 -
4C4X
1
HYES_HUMAN
A:
[29-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
12
PsiBlast_PDB
57.73
32%
-103
- C1 -
1ZD2
1
HYES_HUMAN
P:
[258-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
57
PsiBlast_CBE
57.50
32%
-105
- C1 -
5AM2
7
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
----
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
64
PsiBlast_CBE
57.47
32%
-107
- C1 -
5ALV
4
HYES_HUMAN
A:
[259-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
--
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
--
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
-------
I
P
A
N
------
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
-
F
R
A
S
D
E
S
V
L
S
M
----
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
------------------------
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
--
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
-
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
-----
123
HHSearch
36.48
43%
-120
- C1 -
2CJP
1
?
A:
[11-139]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
H
K
M
V
A
V
N
G
L
N
M
H
L
A
E
L
G
----
E
G
P
T
I
L
F
I
H
G
F
P
E
L
W
Y
S
W
R
H
Q
M
V
Y
L
A
E
R
G
Y
R
A
V
A
P
D
L
R
G
Y
G
D
T
T
G
A
P
LN
D
P
S
K
F
S
I
L
H
L
V
G
D
V
V
A
L
L
E
A
I
A
PN
E
E
K
V
F
V
V
A
H
D
W
G
A
L
I
A
W
H
L
C
L
F
R
P
D
K
V
K
A
L
V
N
L
S
V
H
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
35.16
35%
-122
- C1 -
4INZ
1
?
A:
[20-141]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Y
I
N
V
N
G
V
N
L
H
Y
I
S
K
G
----
Q
G
E
L
M
L
F
L
H
G
F
P
D
F
S
H
I
W
R
H
Q
I
D
E
F
S
-
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
--
G
L
E
S
Y
E
I
D
V
L
V
E
D
I
R
Q
V
I
E
G
L
G
--
Y
S
S
C
T
L
V
V
H
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
A
F
N
G
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
34.42
31%
-121
- C1 -
3G9X
3
DHAA_RHOSO
A:
[12-132]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
--
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
-
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
D
----
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
--
L
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------