@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1997: (2016-05-06 )
MSASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFGPNTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLKEFVDAAVIFGVVVINAIVGFIQESKAEAALQGLRSMVHTHAKVVREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQTGLSVNESALTGESTPVHKDEVALPEGTPVADRRNIAYSGTLVTAGHGAGIVVATGAETELGEIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRRQDAVETFTAAIALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETLGSTTVICADKTGTLTENQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDAPVPVNANAALRWSLLAGACSNDAALVRDGTRWQIVGDPTEGAMLVVAAKAGFNPERLATTLPQVAAIPFSSERQYMATLHRDGTDHVVLAKGAVERMLDLCGTEMGADGALRPLDRATVLRATEMLTSRGLRVLATGMGAGAGTPDDFDENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAGIAVKMITGDHAGTATAIATEVGLLDNTEPAAGSVLTGAELAALSADQYPEAVDTASVFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQANIGVAMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPTNLGEGLVILAAIAVGVALPILPTQILWINMTTAIALGLMLAFEPKEAGIMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNGAGLHEARTAALNLFVVVEAFYLFSCRSLTRSAWRLGMFANRWIILGVSAQAIAQFAITYLPAMNMVFDTAPIDIGVWVRIFAVATAITIVVATDTLLPRIRAQPP
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........---80..-------------.-------.....90........100.......110.......120.......130--.......140.......150.......160.........170.......180.......190.-......200.......210.......220.......230.......240.......250.--......260.......270-------........280.......290.......300.......310.......320.......330.......340.......---------350---------.......360.......370.......380.......390..--.....400.-----..--....410.......420...-....430-------------.........440.......450----...-----....----..460.......470....------...480.....---..490.......500..-.....510.......520------........530-------.........540.......550.......560.......570.......580.....--------------------..590.......600.......610-........620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760....-...770.......780-----........790.......------------------------------------800..--------------------------...-----------------------..810.......820.......830.......840.......850.......860.......870.......880.......890.......900...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSASVSATTAHHGL
P
A
H
E
V
V
L
L
L
ESDPYHGLSD
G
E
A
A
Q
R
L
E
R
FGPN
T
L
A
V
V
T
R
A
S
L
L
A
R
I
L
R
Q
FH
H
P
L
I
Y
V
L
L
V
A
G
T
I
T
---
A
G
L
K
-------------
E
-------
F
V
D
A
A
V
I
F
G
V
V
V
I
N
A
I
V
G
F
I
Q
E
S
K
A
E
A
A
L
Q
G
L
R
S
M
V
H
T
H
A
K
V
V
REGHE--HTMPSEELVPG
D
L
V
L
L
AAGDKV
P
A
D
L
R
L
--
V
R
Q
TGLSVNESALTGESTPVHKDEVALPEGTPV-ADRR
N
I
A
YS
G
T
L
V
TAGHG
A
G
I
V
V
ATGAE
T
E
L
G
E
I
H
R
L
V
G
A
A
E
V
V
AT
P
L
T
A
K
L
A
W
F
S
K
F
L
T
--
I
A
I
L
G
L
A
A
L
T
F
G
V
G
L
L
R
R
--------
Q
D
A
V
E
T
F
T
A
A
I
A
L
A
V
GAIPEGLP
T
A
V
T
I
T
L
A
I
G
M
A
R
M
A
K
R
R
A
V
I
R
RLP
A
V
ETLGS
T
T
V
I
C
ADKTGTLTEN
Q
M
T
V
Q
SIW---------TPH---------G
E
I
R
ATGTGYAP
D
V
L
L
CDTDDAPVPVNAN
A
A
L
R
W
S
L
L
AGACS--ND
A
A
L
VRDG-----
T
R
--
W
Q
I
V
GDPTE
G
A
M
L
V
V
A
AKAG-F
N
P
E
R
---------------
L
A
T
TLP
Q
V
A
AIPFSSE
R
Q
Y
M
------
A
T
L-----HRDG----TD
H
V
V
L
A
K
G
A
V
E
R
M
L
D
L
CG------TEMGADGALRP---
L
D
R
A
T
V
L
R
A
T
E
M
L
T
SRG-
L
R
V
L
A
TGMGAGAGTPDD-------FDENVIP
G
S
---------
L
A
L
T
G
L
Q
AMSDPP
R
A
A
A
A
S
A
V
A
A
C
HSA
G
I
A
V
K
M
I
TGDHAGT
A
T
A
I
A
T
E
VGLLDNTEP--------------------AAGSVLTG
A
E
L
A
ALSADQYPE
A
V
D
--
T
A
S
V
F
ARV
S
P
E
Q
K
L
R
L
V
Q
A
L
Q
ARG
H
V
V
A
M
TGDGVND
A
P
A
L
RQANI
G
V
AMGRGG
T
E
V
A
KDAA
D
M
V
LTDD
D
F
A
T
I
E
A
A
V
E
EGR
G
V
F
D
N
L
T
K
F
I
T
W
T
LPTNLGE
G
L
V
I
L
A
A
I
A
V
G
V
ALPILP
T
Q
I
L
W
I
N
M
T
T
A
I
A
L
G
L
M
L
A
FEPKEAGIMTRPPRDPD-Q
P
L
L
T
G
W
L
V
R
R
T
L
L
V
------
S
T
L
L
V
A
S
A
W
W
L
F
A
W
ELDN------------------------------------GAGL
H
--------------------------
E
A
R
-----------------------
T
A
A
L
N
L
F
V
V
V
E
A
F
Y
L
F
S
C
R
S
L
T
R
S
A
W
R
L
GMFAN
R
W
I
I
L
GV
S
A
Q
A
I
A
Q
F
A
I
T
Y
LPA
M
N
M
VFDTAPI
D
I
G
V
W
V
R
I
F
A
V
A
T
A
I
T
I
V
V
ATDTLLPRIRAQPP
3
PsiBlast_PDB
92.87
33%
-98
- C1 -
4YCM
6
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
Q
L
T
H
FMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
4
PsiBlast_PDB
92.79
33%
-96
- C1 -
4YCN
6
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
Q
L
T
H
FMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
58
PsiBlast_CBE
92.48
33%
-93
- C1 -
2YFY
3
?
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
VDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
13
PsiBlast_PDB
92.03
33%
-95
- C1 -
2AGV
6
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
64
PsiBlast_CBE
92.01
33%
-95
- C1 -
2AGV
6
AT2A1_RABIT
B:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
FVL
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
GV
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERANACNSV
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SRFMEYETD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYV--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
111
HHSearch
91.91
32%
-87
- C1 -
2ZXE
6
?
A:
[44-1019]
------
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
D
L
T
R
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
---
F
L
A
Y
G
I
Q
A
A
TEDEPAN
D
N
-------
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
--
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
E
N
P
-
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
--
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
--------
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
---------
F
D
N
---------
Q
I
H
E
A
D
T
T
E
N
Q
S
---------
G
A
A
F
D
K
T
S
A
T
W
S
A
L
S
R
I
A
A
L
C
--
N
R
A
V
F
Q
A
G
Q
DNVPI
L
K
--
R
S
V
A
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
-
G
S
V
Q
G
---------------
M
R
D
R
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
------
L
S
I
-----
H
E
N
E
KSSE
S
R
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
------
T
I
L
L
-
N
G
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
G
L
G
-
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
EG
Y
P
F
D
A
D
E
P
N
F
P
T
T
D
---------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
G
N
E
T
I
E
D
I
A
A
R
L
NIPIGQVNPRD
A
K
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
G
Q
I
-----
G
M
I
Q
A
L
G
G
F
F
S
Y
F
V
I
L
A
E
N
GFLPMDLIGK
R
V
R
W
D
DRWIS
D
V
E
D
SFG
Q
Q
W
T
Y
E
Q
R
K
I
V
E
F
--------------------------
T
C
H
-----------------------
T
S
F
F
I
S
I
V
V
V
Q
W
A
D
L
I
I
C
K
T
R
R
N
S
I
F
Q
Q
G
-
M
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
C
P
G
T
D
V
A
L
R
M
Y
P
L
K
P
S
W
W
F
C
A
F
P
Y
S
L
I
I
F
L
Y
D
E
M
R
R
F
I
I
R
R
S
P
G
--
26
PsiBlast_CBE
91.81
33%
-94
- C1 -
4J2T
3
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
59
PsiBlast_CBE
91.75
33%
-94
- C1 -
2EAU
5
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
7
PsiBlast_PDB
91.59
33%
-96
- C1 -
1SU4
3
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
32
PsiBlast_CBE
91.57
33%
-94
- C1 -
3NAM
4
?
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
31
PsiBlast_CBE
91.55
33%
-95
- C1 -
3NAN
4
?
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
16
PsiBlast_PDB
91.52
33%
-95
- C1 -
2C8K
4
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
66
PsiBlast_CBE
91.48
33%
-92
- C1 -
1WPG
5
AT2A1_RABIT
C:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
FVL
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
GV
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERANACNSV
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SRFMEYETD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYV--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
67
PsiBlast_CBE
91.39
33%
-92
- C1 -
1WPG
5
AT2A1_RABIT
B:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
FVL
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
GV
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERANACNSV
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SRFMEYETD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYV--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
15
PsiBlast_PDB
91.38
33%
-95
- C1 -
2C88
4
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETIT
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
1
PsiBlast_PDB
91.27
33%
-96
- C1 -
3W5B
6
AT2A1_RABIT
A:
[4-993]
----
A
I
A
M
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEET
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
33
PsiBlast_CBE
91.26
33%
-94
- C1 -
3NAL
3
?
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
35
PsiBlast_CBE
91.23
33%
-91
- C1 -
3N5K
6
?
B:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
FVL
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
GV
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERANACNSV
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SRFMEYETD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYV--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
40
PsiBlast_CBE
91.08
33%
-92
- C1 -
3FGO
8
?
B:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
FVL
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
GV
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERANACNSV
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
SVYCSP
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SRFMEYETD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
GGYV--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
23
PsiBlast_CBE
91.02
33%
-91
- C1 -
4XOU
5
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
38
PsiBlast_CBE
90.31
33%
-93
- C1 -
3FPS
4
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
G
E
E
TITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGDF
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERANA
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
9
PsiBlast_PDB
90.27
33%
-92
- C1 -
1T5T
6
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
VDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
34
PsiBlast_CBE
89.96
33%
-91
- C1 -
3N8G
5
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
20
PsiBlast_PDB
89.96
33%
-94
- C1 -
2OA0
3
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
G
E
E
TITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
------HGGSWI--
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHEIFEA
P
------
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
14
PsiBlast_PDB
89.76
33%
-93
- C1 -
2BY4
5
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
GV
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
8
PsiBlast_PDB
89.51
33%
-92
- C1 -
1T5S
5
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
71
PsiBlast_CBE
89.43
33%
-92
- C1 -
3TLM
5
AT2A1_BOVIN
A:
[3-973]
---------
A
A
H
S
K
T
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
L
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETV
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LT
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
I
G
I
V
A
T
T
G
V
G
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
---------
I
I
D
RIDGD
L
C
L
L
N
E
F
S
V
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
V
R
S
G
Q
Y
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
I
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
------
S
V
Y
C
S
P
AK
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
TK
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
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R
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A
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R
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I
T
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D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
D
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
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R
--
R
A
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C
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A
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A
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-
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A
A
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A
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N
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A
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A
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L
L
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V
N
L
V
T
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G
L
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A
L
G
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N
P
P
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L
D
I
M
D
R
P
P
R
T
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
L
Y
A
---
E
D
------------------------------------
G
P
H
V
T
--------------------------
Y
S
Q
LTHFMKCDFEGVDCEVFEAP
Q
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
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N
Q
S
L
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R
M
P
P
W
V
N
I
W
L
V
G
S
I
G
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
Q
A
L
D
L
Y
H
W
L
M
V
L
K
I
S
---------------------
39
PsiBlast_CBE
88.39
33%
-93
- C1 -
3FPB
6
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSW
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
19
PsiBlast_PDB
88.27
33%
-92
- C1 -
2O9J
4
AT2A1_RABIT
A:
[3-987]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
--------------
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
25
PsiBlast_CBE
73.20
33%
-39
- C1 -
4UU0
6
AT2A1_RABIT
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
49
PsiBlast_CBE
73.13
33%
-39
- C1 -
3AR5
6
AT2A1_RABIT
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
LC
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHF
E
G
L
D
C
EIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
52
PsiBlast_CBE
70.88
33%
-46
- C1 -
3AR2
6
?
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGSWI
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
57
PsiBlast_CBE
70.60
33%
-45
- C1 -
2ZBD
7
?
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
DKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
48
PsiBlast_CBE
69.66
33%
-40
- C1 -
3AR6
6
AT2A1_RABIT
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
IDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
GT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHF
E
G
L
D
C
EIFEAP
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
24
PsiBlast_CBE
69.45
33%
-40
- C1 -
4UU1
9
AT2A1_RABIT
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
IIDKVDGD
F
C
S
L
---------
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
---
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
-----
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
N
T
E
V
RNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
-----
S
R
A
A
----
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
YVRVGT
T
R
V
P
M
T
G
---
P
---
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
D
T
L
R
C
L
A
L
---
A
T
R
D
T
P
P
K
-------
R
E
E
M
V
L
D
D
S
SR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
--------------------
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
--
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P-----------------------------------
G
V
T
Y
H
QLTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
-----------------------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
---
V
I
G
L
D
E
I
L
K
F
I
-----
47
PsiBlast_CBE
69.23
33%
-39
- C1 -
3AR7
6
AT2A1_RABIT
A:
[6-988]
---------
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
-------------
E
GEE
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
LS
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
PVHGGS
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
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-----