@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2032: (2016-05-07 )
MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDKDRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPADFVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELAAASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANTDRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHASRDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRPIDEVFHVRAKDHR
Atome Classification :
(20 SA)
.........10..--......20........30.--.......40........50........60-........70........80........90........100.......110-........120....-...--130.......140...-------....150....-....160.......170.-....------------..-------180.......190.......200.......210.......220...-....230.......240--------------------.----------------.--------------------.-----------------------.--------------.------....250.......260.......270......--.280.......----290.-.-.......300.......310.--........320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPD
T
M
V
T
T
D
V
I
K
S
--
A
V
Q
L
A
CRAPSLHNSQP
W
R
W
--
I
AED
H
T
V
A
L
F
LDKD
R
V
L
Y
ATDHSG
R
E
A
L
L
-
G
C
G
A
V
L
D
H
F
R
V
A
M
AAAGTTANVERFPNPNDP
L
H
L
A
SIDFSP
A
D
FVTEGHR--LRA
D
A
I
L
L
RRTDRLP-FAE--PP
D
W
D
L
V
E
S
Q
L
R
T
T
V
T-------A
D
T
V
R
I
-
D
V
I
A-DDM
R
P
E
L
A
A
A
S
K
L
T
E
S
L
R
-LYDS------------SY-------
H
A
E
L
F
W
WTGAFETSEGIP
H
S
S
L
V
S
A
AESD
R
V
TFGRDFPVVANTDRR-PEFGHDR
S
K
V
L
V
L
S
T----------------------Y----------------D--------------------
N
-----------------------
E
--------------
R
------
A
S
L
L
R
C
G
E
M
L
S
A
V
L
L
D
A
T
M
A
G
L
A
T
C
T
L
T
H
I
T
E
L
--HA
S
R
D
L
V
A
A
L
I----G--Q-P-A
T
P
Q
A
L
V
RVGLAPEMEEP--P--PATPRR
P
I
D
E
V
F
H
VRAKDHR
14
HHSearch
99.58
56%
-94
- C6 -
2YMV
9
?
A:
[3-327]
-
S
D
T
R
L
D
V
A
T
L
A
N
--
A
V
Q
L
A
A
R
A
P
S
L
H
N
T
Q
P
W
R
L
--
I
A
E
D
G
E
L
K
L
F
L
D
P
S
R
V
V
R
S
T
D
R
S
S
R
E
A
V
M
-
S
C
G
V
L
L
D
H
L
R
V
A
L
A
A
A
G
W
D
T
E
V
Q
R
F
P
N
P
N
D
R
D
H
L
A
T
L
S
F
R
P
L
Q
F
V
T
E
G
H
R
--
K
R
A
D
A
I
L
A
R
R
T
D
R
L
P
-
M
S
A
--
Y
V
D
W
D
A
F
E
T
L
L
R
A
R
L
G
-------
D
G
P
V
H
M
-
D
T
L
G
-
E
D
V
R
E
E
V
A
E
A
A
A
L
T
E
S
L
R
-
L
Y
D
A
------------
A
Y
-------
H
S
E
L
A
W
W
T
T
P
F
A
T
E
D
G
I
P
Q
T
A
L
I
S
A
E
E
S
E
R
V
A
V
S
R
D
F
P
V
A
P
H
-
S
S
R
R
P
A
L
N
N
D
A
A
T
I
V
V
L
S
T
----------------------
D
----------------
G
--------------------
Y
-----------------------
S
--------------
R
------
E
D
A
L
D
A
G
E
G
L
S
K
V
L
L
E
C
T
M
S
G
L
A
T
C
P
V
T
H
V
T
E
L
--
H
T
S
R
D
I
I
G
R
L
I
----
V
--
R
-
D
-
A
C
P
Q
V
L
V
R
I
G
L
A
P
A
L
D
E
V
--
P
--
P
P
T
P
R
R
P
V
D
A
F
L
E
V
R
-----
1
PsiBlast_PDB
99.08
55%
-93
- C6 -
2YMV
9
?
A:
[4-329]
--
D
T
R
L
D
V
A
T
L
A
N
--
A
V
Q
L
A
A
R
A
P
S
L
H
N
T
Q
P
W
R
L
--
I
A
E
D
G
E
L
K
L
F
L
D
P
S
R
V
V
R
S
T
D
R
S
S
R
E
A
V
M
-
S
C
G
V
L
L
D
H
L
R
V
A
L
A
A
A
G
W
D
T
E
V
Q
R
F
P
N
P
N
D
R
D
H
L
A
T
L
S
F
R
P
L
Q
F
V
T
E
G
H
R
--
K
R
A
D
A
I
L
A
R
R
T
D
R
L
P
-
M
S
A
--
Y
V
D
W
D
A
F
E
T
L
L
R
A
R
L
G
-------
D
G
P
V
H
M
-
D
T
L
G
-
E
D
V
R
E
E
V
A
E
A
A
A
L
T
E
S
L
R
-
L
Y
D
A
------------
A
Y
-------
H
S
E
L
A
W
W
T
T
P
F
A
T
E
D
G
I
P
Q
T
A
L
I
S
A
E
E
S
E
R
V
A
V
S
R
D
F
P
V
A
P
H
S
S
R
R
-
P
A
L
N
N
D
A
A
T
I
V
V
L
S
T
----------------------
D
----------------
G
--------------------
Y
-----------------------
S
--------------
R
------
E
D
A
L
D
A
G
E
G
L
S
K
V
L
L
E
C
T
M
S
G
L
A
T
C
P
V
T
H
V
T
E
L
--
H
T
S
R
D
I
I
G
R
L
I
----
V
--
R
-
D
-
A
C
P
Q
V
L
V
R
I
G
L
A
P
A
L
D
E
V
--
P
--
P
P
T
P
R
R
P
V
D
A
F
L
E
V
R
P
R
---
34
Fugue
92.61
54%
-83
- C6 -
2YMV
9
?
A:
[3-329]
-
S
D
T
R
L
D
V
A
T
L
A
N
--
A
V
Q
L
A
A
R
A
P
S
L
H
N
T
Q
P
W
R
L
--
I
A
E
D
G
E
L
K
L
F
L
D
P
S
R
V
V
R
S
T
D
R
S
S
R
E
-
A
V
M
S
C
G
V
L
L
D
H
L
R
V
A
L
A
A
A
G
W
D
T
E
V
Q
R
F
P
N
P
N
D
R
D
H
L
A
T
L
S
F
R
P
L
Q
F
V
T
E
G
H
R
--
K
R
A
D
A
I
L
A
R
R
T
D
R
L
P
M
S
A
Y
--
V
D
W
D
A
F
--
E
T
L
L
R
A
R
L
-------
G
D
G
P
V
H
M
D
T
L
G
-
E
D
V
R
E
E
V
A
E
A
A
A
L
T
E
S
L
R
-
L
Y
D
A
------------
A
Y
-------
H
S
E
L
A
W
W
T
T
P
F
A
T
E
D
G
I
P
Q
T
A
L
I
S
A
E
E
S
E
R
V
A
V
S
R
D
F
P
V
A
P
H
S
S
R
R
-
P
A
L
N
N
D
A
A
T
I
V
V
L
S
T
----------------------
D
----------------
G
--------------------
Y
-----------------------
S
--------------
R
------
E
D
A
L
D
A
G
E
G
L
S
K
V
L
L
E
C
T
M
S
G
L
A
T
C
P
V
T
H
V
T
E
L
--
H
T
S
R
D
I
I
G
R
L
I
----
V
--
R
-
D
-
A
C
P
Q
V
L
V
R
I
G
L
A
P
A
L
D
E
V
--
P
--
P
P
T
P
R
R
P
V
D
A
F
L
E
V
R
P
R
---
29
HHSearch
56.59
21%
-87
- C6 -
1BKJ
3
FRP_VIBHA
A:
[2-190]
-------------------------------------------------------------------------------------------------------------------
N
--
N
T
I
E
T
I
L
A
H
R
S
I
R
K
--
F
T
A
--
V
P
I
T
D
E
Q
R
Q
T
I
I
Q
A
G
L
A
ASSSSM
L
Q
V
V
S
I
-
V
R
V
T
D
S
E
K
R
N
E
L
A
Q
F
A
G
N
Q
------------------------------------------------------------------------------
A
Y
V
E
S
A
A
E
F
L
V
F
C
I
----------------------
D
----------------
Y
--------------------
Q
R
H
A
T
I
NPDVQADF
T
E
L
-------
T
--------------
L
------
I
G
A
V
D
S
G
I
M
A
Q
N
C
L
L
A
A
E
S
M
G
L
G
G
V
Y
I
G
G
L
R
N
S
--
A
---
A
Q
V
D
E
L
L
----
G
LP
E
-
N
-
S
A
V
L
F
G
M
C
L
G
H
P
D
Q
N
-----
P
--
E
V
K
P
R
L
P
A
H
V
V
V
H
E
N
Q
Y
---
15
HHSearch
52.64
19%
-81
- C6 -
4XOM
1
?
A:
[9-206]
------------------------------------------------------------------------------------------------------------------
E
L
--
G
R
Q
Q
A
Q
L
L
R
R
S
V
R
R
--
F
S
T
--
D
P
V
P
G
D
L
V
E
A
A
V
A
E
A
L
TAPAPHH
T
R
P
T
R
F
-
V
W
L
Q
T
P
A
I
R
A
R
L
L
D
R
M
K
D
K
W
R
S
D
-
L
T
S
D
------------------------------------
G
L
P
A
D
A
I
--
E
---------
R
-
R
V
A
R
-------
G
Q
I
L
Y
D
A
P
E
V
V
I
P
M
L
----------------------
V
----------------
P
--------------------
D
G
A
H
S
Y
PD
A
A
R
T
D
A
E
---------
H
--------------
T
------
M
F
T
V
A
V
G
A
A
V
Q
A
L
L
V
A
L
A
V
R
G
L
G
S
C
W
I
G
S
T
I
F
A
--
A
---
D
L
V
R
D
E
L
----
D
LP
V
-
D
-
W
E
P
L
G
A
I
A
I
G
Y
A
D
E
P
-----
S
--
G
L
R
D
P
V
P
A
A
D
L
L
I
L
------
25
HHSearch
52.22
17%
-76
- C6 -
3GFA
8
?
A:
[2-197]
----------------------------------------------------------------------------------------------------------------------
M
I
S
D
S
I
S
K
R
R
S
I
R
K
--
Y
K
N
--
Q
S
I
S
H
E
T
I
E
K
I
I
E
A
G
I
N
APSSKN
R
Q
P
W
R
F
-
V
V
I
T
E
K
E
K
E
S
M
L
K
A
M
S
K
G
I
Q
N
E
I
--
N
D
N
------------
G
L
----------
L
P
G
S
R
Q
-------------
H
I
A
---------
G
A
-
N
Y
T
-------
V
E
I
M
K
Q
A
P
V
T
I
F
I
L
N
----------------------
I
----------------
L
--------------------
G
-----------------------
K
SPL
E
K
L
S
P
E
E
R
F
Y
E
M
------
A
N
M
Q
S
I
G
A
A
I
Q
N
M
S
L
T
A
V
E
L
G
L
G
S
L
W
I
C
D
V
Y
F
A
--
Y
---
R
E
L
C
E
W
L
----
N
--
T
-
D
-
S
Q
L
V
A
A
I
S
L
G
Y
P
D
E
E
-----
P
--
S
R
R
P
R
L
Q
L
S
D
V
T
E
W
------
21
HHSearch
51.75
14%
-87
- C6 -
1ZCH
2
NFRA2_BACSU
A:
[2-188]
-------------------------------------------------------------------------------------------------------------------
N
--
E
V
I
K
S
L
T
D
H
R
S
I
R
S
--
Y
T
D
--
E
P
V
A
Q
E
Q
L
D
Q
I
I
E
A
V
Q
S
APSSIN
G
Q
Q
V
T
V
-
I
T
V
Q
D
K
E
R
K
K
K
I
S
E
L
A
G
G
Q
P
-----------------------------------
W
I
-------------------------------------------
D
Q
A
P
V
F
L
L
F
C
A
DF
N
R
A
K
I
A
L
EDLHDFKMEITNG
L
----------------
E
--------------------
S
-----------------------
V
--------------
L
------
V
G
A
V
D
A
G
I
A
L
G
T
A
T
A
A
A
E
S
L
G
L
G
T
V
P
I
G
A
V
R
G
N
--
P
---
Q
E
L
I
E
L
L
----
E
LP
K
-
Y
-
V
F
P
L
S
G
L
V
I
G
H
P
A
D
R
-----
S
--
A
K
K
P
R
L
P
Q
E
A
V
N
H
Q
E
T
Y
L
--
24
HHSearch
51.07
19%
-81
- C6 -
3EOF
2
?
A:
[2-184]
-----------------------------------------------------------------------------------------------------------------------
M
M
D
T
V
K
N
R
R
T
I
R
K
--
Y
Q
Q
--
K
D
I
T
P
D
L
L
N
D
L
L
E
T
S
F
RASTMGG
M
Q
L
Y
S
V
-
V
V
T
R
D
A
E
K
K
E
I
L
S
P
A
H
F
N
Q
------------------------------------------------------------------------------
P
M
V
K
E
A
P
V
V
L
T
F
C
A
----------------------
D
----------------
F
R
R
F
C
K
Y
C
Q
E
R
NAVPGYGN
L
M
S
-----------------------
F
--------------
L
------
N
A
A
M
D
T
L
L
V
A
Q
T
F
C
T
L
A
E
E
A
G
L
G
I
C
Y
L
G
T
T
T
Y
N
--
P
---
Q
M
I
I
D
A
L
----
H
LP
E
-
L
-
V
F
P
I
T
T
V
T
V
G
Y
P
A
E
S
-----
P
--
K
Q
V
D
R
L
P
I
E
G
I
I
H
E
E
S
Y
H
--
18
HHSearch
51.03
17%
-78
- C6 -
1F5V
2
NFSA_ECOLI
A:
[2-182]
-------------------------------------------------------------------------------------------------------------------
T
--
P
T
I
E
L
I
C
G
H
R
S
I
R
H
--
F
T
D
--
E
P
I
S
E
A
Q
R
E
A
I
I
N
S
A
R
A
TSSSSF
L
Q
C
S
S
I
-
I
R
I
T
D
K
A
L
R
E
E
L
V
T
L
T
G
G
Q
K
-----------------------------------
H
-------------------------------------------
V
A
Q
A
A
E
F
W
V
F
C
A
----------------------
D
F
N
R
H
L
Q
I
C
P
DAQLGL
A
E
--------------------
Q
-----------------------
L
--------------
L
------
L
G
V
V
D
T
A
M
M
A
Q
N
A
L
I
A
A
E
S
L
G
L
G
G
V
Y
I
G
G
L
R
N
N
--
I
---
E
A
V
T
K
L
L
----
K
LP
Q
-
H
-
V
L
P
L
F
G
L
C
L
G
W
P
A
D
N
-----
P
--
D
L
K
P
R
L
P
A
S
I
L
V
H
E
N
S
Y
Q
--
17
HHSearch
50.36
14%
-85
- C6 -
3GB5
3
IYD1_MOUSE
A:
[53-254]
-----------------------------------------------------------------------------------------------------------------
R
S
Q
--
E
F
Y
E
L
L
N
K
R
R
S
V
R
F
--
I
S
S
--
E
H
V
P
M
E
V
I
E
N
V
I
K
A
A
G
T
A
P
S
G
AH
T
E
P
W
T
F
-
V
V
V
K
D
P
D
M
K
H
K
I
R
E
I
I
E
E
E
E
E
I
--------------------------------------------------------------------------
K
E
Y
L
D
T
A
P
V
L
I
L
I
F
K
----------------------
Q
----------------
V
------------------------------------------------------------------
Y
N
E
I
S
V
S
I
A
C
G
L
L
L
A
A
L
Q
N
A
G
L
V
T
V
T
T
T
P
L
N
C
G
------
P
R
L
R
V
L
L
----
G
RP
S
-
H
-
E
K
L
L
V
L
L
P
V
G
Y
P
S
R
D
A
-
T
--
V
--
P
D
L
K
R
K
A
L
D
Q
I
M
V
T
V
H
----
28
HHSearch
50.02
14%
-83
- C6 -
3E10
11
?
A:
[3-165]
-------------------------------------------------------------------------------------------------------------------------
D
I
I
N
N
R
R
S
I
R
N
--
Y
K
G
--
K
K
V
E
K
E
K
I
E
K
L
L
R
A
A
M
Q
APSAGN
Q
Q
P
W
E
F
-
I
V
L
E
D
R
E
N
I
D
K
L
S
N
F
S
K
Y
------------------------------------------------------------------------------
A
N
S
L
K
T
A
P
L
A
I
V
L
L
A
----------------------
D
----------------
E
--------------------
E
KMKI-------------------
S
--------------
E
------
M
W
E
Q
D
M
A
A
A
A
E
N
I
L
L
E
A
A
Y
L
D
L
G
A
V
W
L
G
A
Q
P
I
E
---
E
R
V
K
N
L
K
E
M
F
----
N
LK
S
-
N
-
I
K
P
F
C
V
I
S
V
G
Y
P
E
N
S
--
E
--
N
--
K
F
I
D
R
F
D
A
K
R
I
H
I
-------
19
HHSearch
49.87
18%
-67
- C6 -
3N2S
3
NFRA1_BACSU
A:
[2-188]
-------------------------------------------------------------------------------------------------------------------
N
--
N
T
I
E
T
I
L
N
H
R
S
I
R
S
--
F
T
D
--
Q
L
L
T
A
E
E
I
D
T
L
V
K
S
A
Q
A
ASTSSY
V
Q
A
Y
S
I
-
I
G
V
S
D
P
E
K
K
R
E
L
S
V
L
A
G
N
Q
P
-----------------------------------
Y
V
E
K
N
------
G
H
-
F
F
---------
V
F
C
A
D
L
Y
R
H
Q
Q
L
A
E
--
E
K
G
E
H
I
S
E
---
L
L
E
N
----------------------
T
----------------
E
--------------------
M
-----------------------
F
--------------
M
------
V
S
L
I
D
A
A
L
A
A
Q
N
M
S
I
A
A
E
S
M
G
L
G
I
C
Y
I
G
G
I
R
N
E
--
L
---
D
K
V
T
E
V
L
----
Q
TP
D
-
H
-
V
L
P
L
F
G
L
A
V
G
H
P
A
N
L
-----
S
--
G
K
K
P
R
L
P
K
Q
A
V
Y
H
E
N
T
Y
N
--
22
HHSearch
49.67
16%
-73
- C6 -
3EO8
8
?
A:
[2-218]
-------------------------------------------------------------------------------------------------------------------
M
--
E
L
Q
D
T
I
F
K
R
Q
S
V
R
K
--
F
K
N
--
Q
D
V
S
D
E
D
I
L
K
M
I
K
A
A
G
A
APSGKN
I
Q
N
W
H
F
-
V
V
I
K
R
R
D
L
M
E
K
I
A
D
V
I
T
K
K
Q
Q
E
I
-
L
V
E
M
------------
D
---------
K
---
V
S
V
-------
D
--
K
-
A
N
---------
R
-
F
R
K
F
V
K
N
F
------
T
L
F
Y
L
K
A
P
V
L
V
L
V
F
T
----------------------
K
----------------
V
--------------------
Y
NPSG
Y
Y
E
L
E
L
I
DAP
K
E
T
I
D
K
L
F
I
R
--------------
N
------
P
G
M
Q
S
L
G
A
A
I
E
N
F
T
L
S
A
I
E
L
G
Y
G
S
C
W
L
T
S
Q
N
Y
A
--
A
---
D
E
I
E
A
V
L
E
A
E
T
G
F-
E
K
G
E
Y
F
L
G
A
M
L
A
L
G
V
P
E
D
N
-----
L
--
K
S
P
S
K
K
P
V
E
E
I
C
T
F
I
-----
33
HHSearch
49.38
17%
-92
- C6 -
3G14
5
?
A:
[2-178]
-------------------------------------------------------------------------------------------------------------------
M
--
E
F
Y
E
V
I
K
K
R
K
S
I
K
K
--
F
E
Q
--
T
A
I
D
R
D
K
L
L
K
I
I
D
M
A
M
R
APSWKN
K
T
P
Y
K
F
-
I
V
V
E
S
D
K
L
K
L
D
I
A
N
A
I
E
N
K
T
S
----------------------------------
A
-----------------
A
----------------------
S
E
A
V
L
N
S
P
M
T
I
V
A
V
A
----------------------
N
----------------
P
--------------------
E
ESGDVSG----------------
K
--------------
E
------
I
Y
L
I
D
T
A
I
A
M
E
H
I
V
L
G
A
T
D
E
G
Y
G
T
C
W
I
A
A
F
N
E
-------
N
K
I
K
E
A
L
----
K
IP
D
-
N
-
L
R
V
V
A
L
T
P
L
G
V
P
K
D
-------------
K
K
D
M
D
E
Y
L
Y
I
D
K
W
---
26
HHSearch
49.14
14%
-85
- C6 -
3M5K
4
?
A:
[5-169]
------------------------------------------------------------------------------------------------------------------
E
N
--
Q
T
L
E
T
I
L
N
R
K
S
V
R
-
K
-
Y
K
D
--
R
P
V
E
K
E
K
I
D
K
L
I
R
A
G
M
A
A
P
S
S
RD
R
R
P
W
E
F
-
I
I
V
T
D
R
K
A
L
D
T
M
A
E
G
L
P
F
------------------------------------------------------------------------------
A
R
M
L
K
E
T
R
Q
A
I
V
V
C
G
----------------------
D
----------------
T
--------------------
I
KS---------------------
S
--------------
N
------
A
W
F
L
D
C
S
A
A
S
Q
N
L
L
L
A
A
E
S
M
G
L
G
A
V
W
T
A
V
Y
P
Y
P
---
D
R
I
E
I
V
R
K
E
L
----
R
LP
D
-
H
-
I
M
P
L
N
V
I
P
V
G
Y
P
M
Q
K
-----
E
--
T
P
K
N
K
Y
N
V
Q
Q
I
H
H
-------
27
HHSearch
47.18
16%
-59
- C6 -
3GR3
11
?
A:
[5-227]
-----------------------------------------------------------------------------------------------------------------
A
P
I
--
D
I
F
Q
S
I
L
S
R
K
S
I
R
A
--
F
T
D
--
Q
P
V
T
Q
E
T
I
R
E
I
L
K
L
A
A
R
APSGTN
L
Q
P
W
Q
V
-
I
V
L
T
-
G
K
I
L
Q
K
V
G
Q
E
L
S
Q
L
V
L
S
G
-
I
K
G
E
R
EYHYYPR
Q
W
R
E
P
Y
-------
L
S
R
R
R
K
V
G
L
D
L
Y
K
S
L
G
I
Q
K
G
D
Q
-----------
E
K
M
L
H
Q
K
----
A
K
-
N
F
L
F
Y
G
A
P
V
G
L
L
F
T
I
----------------------
D
----------------
H
--------------------
D
M----------------------
E
--------------
M
------
G
S
W
L
D
L
G
M
F
M
Q
T
I
M
L
A
A
R
G
F
G
L
D
T
C
A
Q
A
A
F
A
D
Y
--
H
---
K
Q
I
R
S
L
L
----
S
VP
S
-
D
-
R
H
I
I
C
G
M
A
L
G
Y
R
D
M
N
A
-
P
EN
N
--
F
E
T
E
R
E
P
I
D
N
F
V
H
F
I
K
----
23
HHSearch
46.67
15%
-54
- C6 -
3K6H
5
?
A:
[8-196]
------------------------------------------------------------------------------------------------------------------
D
I
--
K
L
L
D
Y
L
R
V
R
R
S
T
P
A
--
L
Q
L
S
E
P
G
P
S
K
G
E
I
E
E
I
L
R
L
A
V
RVPDHGK
L
A
P
W
R
F
-
V
V
Y
R
-
G
E
E
R
V
R
L
S
E
A
A
L
R
I
A
L
E
K
-
N
P
D
L
---------------------------------------------
D
--------
L
Q
Q
Q
E
A
E
-------
R
T
R
F
T
R
A
P
V
V
I
A
V
I
S
----------------------
T
----------------
A
--------------------
K
-----------------------
P
--------------
H
FKIP
E
W
E
Q
V
M
S
A
G
A
V
C
L
N
V
I
F
A
A
N
A
S
G
F
A
A
N
W
L
T
E
W
L
A
F
--
D
---
P
A
F
L
A
E
I
----
G
VS
A
-
E
-
E
K
V
A
G
Y
I
H
I
G
S
T
T
F
P
-----
P
--
V
E
R
P
R
P
E
L
A
D
V
V
T
W
V
G
D
---
31
HHSearch
46.51
12%
-65
- C6 -
3EK3
5
?
A:
[4-188]
------------------------------------------------------------------------------------------------------------------
T
N
--
E
V
L
E
T
I
K
A
R
R
S
V
R
A
--
Y
D
R
--
K
Q
I
P
A
D
D
L
N
A
I
L
E
A
G
A
Y
APSGMH
Y
E
T
W
H
F
-
T
A
V
C
N
T
V
K
L
E
E
L
N
E
R
I
K
G
A
F
A
K
S
-----------------------------
D
D
K
H
L
R
E
----
R
G
-----
H
--
S
-------------
E
T
-------
Y
C
C
Y
Y
H
A
P
T
L
V
I
V
S
N
----------------------
E
----------------
P
--------------------
K
-----------------------
Q
--------------
W
------
W
A
G
M
D
C
A
C
A
I
E
N
M
F
L
A
A
T
S
L
G
I
A
S
C
W
I
N
Q
L
G
T
T
CD
D
P
E
V
R
A
Y
L
T
S
L
----
G
VP
E
-
N
-
H
K
V
Y
G
C
V
A
L
G
Y
K
A
E
G
-----
A
--
L
L
K
E
K
T
V
K
A
G
T
I
T
I
------
16
HHSearch
44.84
16%
-62
* C6 *
2WZV
7
NFNB_MYCS2
A:
[15-235]
-----------------------------------------------------------------------------------------------------------------
L
A
Q
--
A
A
E
R
L
I
K
G
R
R
A
V
R
-
A
-
F
R
P
--
D
E
V
P
E
E
T
M
R
A
V
F
E
L
A
G
H
APSNSN
T
Q
P
W
H
V
-
E
V
V
S
-
G
A
A
R
D
R
L
A
E
A
L
V
T
A
H
A
E
E
-
R
V
T
V
------------
D
F
PYREGLF
Q
G
V
L
Q
E
R
R
A
D
F
--
G
S
R
L
Y
A
A
-
L
G
I
A
R
D
Q
--
T
D
L
L
Q
G
Y
N
T
E
-------
S
L
R
F
Y
G
A
P
H
V
A
M
L
F
A
----------------------
P
----------------
N
--------------------
N
T----------------------
E
--------------
A
------
R
I
A
G
D
M
G
I
Y
A
Q
T
L
M
L
A
M
T
A
H
G
I
A
S
C
P
Q
A
L
L
S
F
Y
--
A
---
D
T
V
R
A
E
L
----
G
V-
E
-
N
-
R
K
L
L
M
G
I
S
F
G
Y
A
D
D
T
A
-
A
--
V
NG
V
R
I
P
R
A
G
L
S
E
T
T
R
F
S
R
----
41
Fugue
44.09
19%
-60
- C4 -
4AW9
7
LGMN_HUMAN
A:
[1-263]
-
G
G
K
H
W
V
V
I
V
A
G
S
NG
W
Y
N
Y
R
H
Q
A
D
A
C
H
A
Y
Q
I
I
H
R
N
G
I
P
D
E
Q
I
V
V
M
M
Y
D
--
D
I
A
Y
S
E
D
N
P
T
P
-------
G
I
V
I
N
R
-----------------
P
N
G
T
D
V
Y
Q
G
V
P
K
D
Y
T
G
E
D
V
T
P
Q
N
F
L
A
V
L
R
G
D
A
E
A
V
K
G
I
G
S
G
K
-
V
L
K
--
S
G
P
Q
D
H
V
F
I
Y
F
T
D
H
G
S
-------
T
G
I
L
V
F
---
P
N
-
E
D
L
H
-----
V
K
D
L
N
E
T
I
H
Y
M
Y
K
H
------------
K
M
-------
Y
R
K
M
V
F
Y
I
E
A
C
E
S
G
S
M
M
N
H
-------------
L
P
D
N
I
N
V
Y
A
T
T
A
A
N
-
P
---
R
E
S
S
Y
A
C
---
Y
----------------------
Y
----------------
D
--------------------
E
-----------------------
K
--------------
R
------
S
T
Y
L
--
G
D
W
Y
S
V
N
W
M
E
D
S
D
V
E
----
D
L
T
K
E
T
-
L
--
H
K
Q
Y
H
L
V
K
S
H
-------------
T
Q
T
S
H
V
M
Q
Y
G
N
K
T
I
S
T
M
--
K
------------
V
M
Q
F
Q
G
M
K
R
-