@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2038c: (2016-05-07 )
MASVSFEQATRRYPGTDRPALDRLDLIVGDGEFVVLVGPSGCGKTTSLRMVAGLETLDCGRIRIGERDVTEVDPKDRDVAMVFQNYALYPHMTVAQNMGFALKVAKIGKAEIRERVLAAAKLLDLQSYLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPLSNLDAKLRGQTRNQIAALQRQLGTTTVYVTHDQVEAMTMGDRVAVLSDGVLQQCASPRELYRNPGNVFVAGFIGSPAMNLFRLSIADSTVSLGDWQILLPRAVVGTAAEVIIGVRPEHLELGGAGIEMDVDMVEELGADAYLYGRIVSGGCEMDQSIVARVDGRGPPERGSRVRLCPTPGHLHFFAVDGRRIPG
Atome Classification :
(47 SA)
.........10.......--.20........30........40........50.....-------...60...---.....----70.....---------------..-.80........90-----......-..100........---110..---.....-120--.....-..130.......140.......150.......160.......170...-....180.......190.......200.......210.......220.......230.......240.......-250-.-.-----.--.--------.-.-..260...----.--.-..270..-----.......280---....------.------..290.......300.......310.......320.......330.......340.......-350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAS
V
S
F
E
Q
A
T
R
RYPGTDR--PAL
D
R
L
D
L
I
VGDG
E
F
V
V
L
VGPSGCGKT
T
S
L
R
M
V
AG
L
E
T-------LDCG
R
I
RI---GERDV----TEVDPKD---------------R
D
-
V
A
M
V
F
Q
NYALYP
H
-----
M
T
V
A
QN-M
G
F
A
-
L
K
V
A
KI
G
K
---
A
E
I
R
E
---
R
V
L
A
A
-
A
K
L
--
L
D
L
Q
S
-
Y
LDRKPKDLSGG
Q
R
Q
R
V
A
M
G
R
A
I
VRR
P
Q
V
F
L
MDEP
L
S
N
L
D
A
K
LRGQ
T
R
-
N
Q
I
A
A
L
Q
R
QLGT
T
T
V
Y
V
THDQ
V
E
A
MTMG
D
R
V
A
V
LS
D
G
V
L
Q
Q
CA
S
P
R
E
L
YRNPG
N
V
F
V
A
GFIGSPA
M
N
L
F
R
L
SIA-D-S-T-V-----S--L--------G-
D
-
W
Q
I
L
L
P
R
A
----
V
--V-G
T
A
--
A
E
-----
V
I
I
GV
R
P
E
H
L
---ELGG------A------G
I
E
M
D
V
D
M
V
E
E
LGAD
A
Y
L
Y
G
R
IVSGGCEM
D
Q
S
I
V
A
R
VDGRGPPERG
S
R
V
R
L
CPTPG
H
L
H
F
F
A
-VD
G
R
RIPG
1
PsiBlast_PDB
94.92
50%
-122
- C1 -
4TQU
-
?
S:
[2-354]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
T
----
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
-------
I
S
G
G
T
I
R
I
---
D
G
R
V
I
----
N
D
L
A
P
K
D
---------------
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
---
S
V
I
D
A
---
A
V
K
T
A
-
A
D
I
--
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
-
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
-
S
-
T
-
Q
-----
H
--
V
ELNG----
G
-
N
-
R
I
S
L
L
P
R
A
----
G
--
T
-
H
L
A
PG
Q
E
-----
V
V
F
G
I
R
P
E
D
V
---
T
L
D
G
VEGSER
A
------
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
------
G
D
H
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
----------
3
PsiBlast_PDB
94.81
50%
-122
- C1 -
4XIG
-
?
S:
[2-354]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
T
----
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
-------
I
S
G
G
T
I
R
I
---
D
G
R
V
I
----
N
D
L
A
P
K
D
---------------
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
---
S
V
I
D
A
---
A
V
K
T
A
-
A
D
I
--
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
-
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
-
S
-
T
-
Q
-----
H
--
V
ELNG----
G
-
N
-
R
I
S
L
L
P
R
A
----
G
--
T
-
H
L
A
PG
Q
E
-----
V
V
F
G
I
R
P
E
D
V
---
T
L
D
G
VEGSER
A
------
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
------
G
D
H
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
----------
4
PsiBlast_PDB
94.40
50%
-122
- C1 -
4XTC
-
?
S:
[2-354]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
T
----
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
-------
I
S
G
G
T
I
R
I
---
D
G
R
V
I
----
N
D
L
A
P
K
D
---------------
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
---
S
V
I
D
A
---
A
V
K
T
A
-
A
D
I
--
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
-
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
-
S
-
T
-
Q
-----
H
--
V
ELNG----
G
-
N
-
R
I
S
L
L
P
R
A
----
G
--
T
-
H
L
A
PG
Q
E
-----
V
V
F
G
I
R
P
E
D
V
---
T
L
D
G
VEGSER
A
------
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
------
G
D
H
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
----------
2
PsiBlast_PDB
93.37
50%
-120
- C1 -
4TQV
-
?
C:
[2-354]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
T
----
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
-------
I
S
G
G
T
I
R
I
---
D
G
R
V
I
----
N
D
L
A
P
K
D
---------------
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
---
S
V
I
D
A
---
A
V
K
T
A
-
A
D
I
--
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
-
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
-
S
-
T
-
Q
-----
H
--
V
E
L
NG----
G
-
N
-
R
I
S
L
L
P
R
A
----
G
--
T
-
H
L
A
PG
Q
E
-----
V
V
F
G
I
R
P
E
D
V
---
T
L
D
G
VEGSER
A
------
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
------
G
D
H
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
----------
107
HHSearch
93.30
50%
-125
- C1 -
4TQU
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
--
T
--
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
-------
I
S
G
G
T
I
R
I
---
D
G
R
V
I
----
N
D
L
A
P
K
D
---------------
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
---
S
V
I
D
A
---
A
V
K
T
A
-
A
D
I
--
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
-
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
-
V
-
D
-
S
-
T
QHV--
E
--
L
--------
N
G
G
-
N
R
I
S
L
L
P
R
AG--
T
--
H
L
A
P
G
--
Q
E
-----
V
V
F
G
I
R
P
E
D
V
---
T
L
D
G
------
V
EGSERA
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
------
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
--
108
HHSearch
90.62
49%
-126
- C1 -
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
--
F
--
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
-------
P
T
E
G
R
I
Y
F
---
G
D
R
D
V
----
T
Y
L
P
P
K
D
---------------
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
---
D
E
I
D
K
---
R
V
R
W
A
-
A
E
L
--
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
-
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
-
D
-
G
-
Y
-
L
-----
E
--
G
--------
R
-
G
-
F
R
I
E
L
P
Q
-MDL-
L
--
K
D
Y
V
G
--
K
T
-----
V
L
F
G
I
R
P
E
H
M
---
T
V
E
G
------
V
HMK
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
------
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
--
6
PsiBlast_PDB
89.67
47%
-126
- C1 -
1V43
-
?
A:
[10-370]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
--
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
-------
P
T
E
G
R
I
Y
F
---
G
D
R
D
V
----
T
Y
L
P
P
K
D
---------------
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
---
D
E
I
D
K
---
R
V
R
W
A
-
A
E
L
--
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
-
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
-
D
-
G
-
Y
-
L
-----
E
--
G
--------
R
-
G
-
F
R
I
E
L
P
Q
--------
M
-
D
L
L
--
K
D
YVG
K
T
V
L
F
G
I
R
P
E
H
M
---
T
V
E
G
VHMK
R
T
A
------
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
---
V
K
F
G
---
D
E
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
-
K
D
T
E
K
---
5
PsiBlast_PDB
88.25
47%
-126
- C1 -
1VCI
1
?
A:
[10-370]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
--
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
-------
P
T
E
G
R
I
Y
F
---
G
D
R
D
V
----
T
Y
L
P
P
K
D
---------------
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
---
D
E
I
D
K
---
R
V
R
W
A
-
A
E
L
--
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
-
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
-
D
-
G
-
Y
-
L
-----
E
--
G
--------
R
-
G
-
F
R
I
E
L
P
Q
--------
M
-
D
L
L
--
K
D
YVG
K
T
V
L
F
G
I
R
P
E
H
M
---
T
V
E
G
VHMK
R
T
A
------
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
---
V
K
F
G
---
D
E
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
-
K
D
T
E
K
---
15
PsiBlast_PDB
85.50
44%
-116
- C1 -
3PUV
5
MALK_ECOLI
A:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
PMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
13
PsiBlast_PDB
85.06
44%
-115
- C1 -
3PUZ
2
MALK_ECOLI
A:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
PMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
18
PsiBlast_PDB
85.04
44%
-116
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
PMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
22
PsiBlast_CBE
84.64
44%
-113
- C1 -
4KI0
4
MALK_ECOLI
A:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
PMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
24
PsiBlast_CBE
84.53
44%
-115
- C1 -
3PUZ
2
MALK_ECOLI
B:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
VQVELPMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
110
HHSearch
84.49
45%
-118
- C1 -
2YYZ
3
?
A:
[2-358]
-
P
S
I
R
V
V
N
L
K
K
Y
F
G
K
--
V
--
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
-------
P
T
S
G
E
I
Y
F
---
D
D
V
L
V
----
N
D
I
P
P
K
Y
---------------
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
-----
M
T
V
F
E
N
-
I
A
F
P
-
L
R
A
R
R
I
S
K
---
D
E
V
E
K
---
R
V
V
E
I
-
A
R
K
--
L
L
I
D
N
-
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
-
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
N
F
L
R
D
F
S
V
-
S
V
E
N
K
Q
T
-----
I
L
K
R
--------
D
-
D
-
V
I
I
K
L
P
E
P
----
V
--
D
-
V
K
L
--
K
E
-----
V
V
V
G
I
R
P
E
H
C
---
R
I
S
R
------
E
R
V
E
N--
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
E
-----
I
I
K
V
F
G
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
E
T
I
--
21
PsiBlast_CBE
84.16
44%
-115
- C1 -
4KI0
3
MALK_ECOLI
B:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
VQVELPMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
16
PsiBlast_PDB
84.14
44%
-114
- C1 -
3PUW
5
MALK_ECOLI
A:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
PMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
113
HHSearch
84.05
46%
-109
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-362]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
D
Q
V
Q
V
E
--
L
PM------
P
-
N
R
Q
Q
V
W
L
P
V
E
S---
R
--
D
V
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
---
L
P
S
D
------
I
AD
V
---
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
----
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
---
17
PsiBlast_PDB
83.99
44%
-114
- C1 -
3PUX
5
MALK_ECOLI
A:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
PMP
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
29
PsiBlast_CBE
83.94
44%
-111
- C1 -
2AWN
2
MALK_ECOLI
B:
[2-359]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
--
V
S
K
D
-
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
-------
I
T
S
G
D
L
F
I
---
G
E
K
R
M
----
N
D
T
P
P
A
E
---------------
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
---
E
V
I
N
Q
---
R
V
N
Q
V
-
A
E
V
--
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
-
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
-
T
-
A
-
I
-----
D
--
Q
V
Q
V
E
L
P
M
P
N
-
R
-
Q
Q
V
W
L
P
V
E
----
S
RD
V
-
Q
V
G
--
A
N
-----
M
S
L
G
I
R
P
E
H
L
LPS
D
I
A
D
------
V
------
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
-
E
D
G
-----
109
HHSearch
83.75
40%
-118
- C1 -
2IT1
-
?
A:
[1-357]
M
V
E
I
K
L
E
N
I
V
K
K
F
G
N
--
F
--
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
-------
P
T
S
G
K
I
Y
F
---
D
E
K
D
V
----
T
E
L
P
P
K
D
---------------
R
N
-
V
G
L
V
F
Q
N
W
A
L
Y
P
H
-----
M
T
V
Y
K
N
-
I
A
F
P
-
L
E
L
R
K
A
P
R
---
E
E
I
D
K
---
K
V
R
E
V
-
A
K
M
--
L
H
I
D
K
-
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
-
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
V
E
-
D
-
G
-
K
-
L
-----
V
I-
T
--------
E
-
K
-
S
K
L
P
I
P
K
Q
Y
V
E
I
V
--
K
E
T
G
I
--
T
E
-----
V
I
I
G
F
R
P
H
D
A
---
E
I
V
K
------
G
EGE---
G
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
------
I
V
K
V
F
A
P
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
L
--
49
PsiBlast_CBE
58.66
39%
-106
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[16-240]
----------------
N
T
--
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
-------
P
D
S
G
E
I
S
L
---
S
G
K
T
I
FSKN
T
N
L
P
V
R
E
---------------
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
-
I
A
Y
G
-
L
G
N
G
K
G
R
T
---
A
Q
E
R
Q
---
R
I
E
A
M
-
L
E
L
--
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
-
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
57.78
39%
-104
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[16-245]
----------------
N
T
--
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
-------
P
D
S
G
E
I
S
L
---
S
G
K
T
I
FSKN
T
N
L
P
V
R
E
---------------
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
-
I
A
Y
G
-
L
G
N
G
K
G
R
T
---
A
Q
E
R
Q
---
R
I
E
A
M
-
L
E
L
--
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
-
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
53.41
32%
-95
- C1 -
3TIF
7
Y796_METJA
A:
[2-225]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
-------
P
T
E
G
E
V
Y
I
---
D
N
I
K
T
----
N
D
L
D
D
D
E
L
T
K
I
R
----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
-
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
---
R
A
L
E
C
-
L
K
M
--
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
52.43
32%
-99
- C1 -
3TIF
7
Y796_METJA
B:
[2-225]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
II
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
-------
P
T
E
G
E
V
Y
I
---
D
N
I
K
T
----
N
D
L
D
D
D
E
LTKIR----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
-
V
E
L
P
-
L
I
F
K
Y
R
G
A
MSG
E
E
R
R
K
---
R
A
L
E
C
-
L
K
M
--
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
52.23
34%
-95
- C1 -
3C41
3
?
K:
[19-240]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
51.41
34%
-89
- C1 -
2OLK
1
?
C:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
51.00
34%
-90
- C1 -
2OLK
1
?
A:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAK
D
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
50.74
34%
-93
- C1 -
2OLJ
4
?
A:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
50.52
34%
-93
- C1 -
3C41
3
?
J:
[19-240]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
50.12
34%
-92
- C1 -
2OLK
1
?
D:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
50.11
33%
-94
- C1 -
1L2T
4
Y796_METJA
A:
[20-225]
---------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
-------
P
T
E
G
E
V
Y
I
---
D
N
I
K
T
----
N
D
L
D
D
D
E
L
T
K
I
R
----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
-
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
---
R
A
L
E
C
-
L
K
M
--
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
50.08
34%
-93
- C1 -
3C4J
4
?
B:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
49.89
34%
-89
- C1 -
2Q0H
4
?
B:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
49.76
34%
-90
- C1 -
3C4J
3
?
A:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
49.24
34%
-91
- C1 -
2OLK
2
?
B:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
49.17
34%
-92
- C1 -
2Q0H
4
?
A:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
48.99
38%
-85
- C1 -
4YMV
1
?
J:
[16-229]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
PTKGEVF
I
D
G
V
K
I
N
N
---
G
K
V
N
I
----
N
K
V
R
Q
K
-------------------
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
---
K
E
A
E
E
LAV
D
L
L
A
K
-
V
G
L
--
L
D
K
K
----
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
48.81
38%
-82
- C1 -
4YMV
1
?
A:
[16-229]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
PT
K
G
E
V
F
I
D
G
V
K
I
N
N
---
G
K
V
N
I
----
N
K
V
R
Q
K
-------------------
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
-
V
G
L
--
L
D
K
K
----
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
48.26
33%
-96
- C1 -
1L2T
4
Y796_METJA
B:
[20-225]
---------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
-------
P
T
E
G
E
V
Y
I
---
D
N
I
K
T
----
N
D
L
D
D
D
E
LTKIR----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
-
V
E
L
P
-
L
I
F
K
Y
R
G
A
MSG
E
E
R
R
K
---
R
A
L
E
C
-
L
K
M
--
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
48.03
34%
-88
- C1 -
2OLJ
3
?
B:
[40-259]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-------
F
D
E
G
E
I
I
I
---
D
G
I
N
L
KAKD
T
N
L
N
K
V
R
---------------
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
---
E
K
A
E
A
---
K
A
M
E
L
-
L
D
K
--
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
47.91
38%
-86
- C1 -
4YMU
2
?
J:
[16-229]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
PTKGEVF
I
D
G
V
K
I
N
N
---
G
K
V
N
I
----
N
K
V
R
Q
K
-------------------
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
---
K
E
A
E
E
LAV
D
L
L
A
K
-
V
G
L
--
L
D
K
K
----
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
47.76
38%
-85
- C1 -
4YMU
2
?
A:
[16-229]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
PT
K
G
E
V
F
I
D
G
V
K
I
N
N
---
G
K
V
N
I
----
N
K
V
R
Q
K
-------------------
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
-
V
G
L
--
L
D
K
K
----
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
47.00
32%
-87
- C1 -
4U00
3
?
A:
[20-238]
----------------------
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
-------
F
Q
E
G
E
V
V
V
DGL
S
V
K
D
D
----
R
A
L
R
E
I
R
---------------
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-----
M
T
V
L
E
N
-
V
T
L
A
P
M
R
V
R
R
W
P
R
---
E
K
A
E
K
---
K
A
L
E
L
-
L
E
R
--
V
G
I
L
D
-
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
35.63
31%
-72
- C1 -
1B0U
4
HISP_SALTY
A:
[45-253]
---------------------------------------------
K
S
T
F
L
R
C
I
N
F
L
E
K
-------
P
S
E
G
A
I
I
V
---
N
G
Q
N
I
----
N
L
V
R
D
K
D
GQLKVAD
K
N
Q
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
-----
M
T
V
L
E
N
V
M
E
A
P
-
I
Q
V
L
G
L
S
K
---
H
D
A
R
E
---
R
A
L
K
Y
L
A
K
V
--
G
I
D
E
R
-
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
-
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
34.85
32%
-78
- C1 -
4HLU
3
ECFA2_THEMA
B:
[21-216]
----------------
E
K
--
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
-------
P
T
S
G
D
V
L
Y
D--
G
E
R
K
K
G---
Y
E
I
R
------------------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
-
V
A
F
A
-
V
K
N
F
Y
P
D
R
---
D
P
V
-
P
---
L
V
K
K
A
-
M
E
F
VG
L
D
F
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
--
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
34.74
32%
-80
- C1 -
4HLU
2
ECFA2_THEMA
A:
[21-216]
----------------
E
K
--
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
-------
P
T
S
G
D
V
L
Y
D--
G
E
R
K
K
G
---
Y
E
I
R
------------------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
-
V
A
F
A
-
V
K
N
F
Y
P
D
R
---
D
P
V
-
P
---
L
V
K
K
A
-
M
E
F
V
G
L
D
F
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
--
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
34.63
32%
-80
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[20-215]
----------------
E
K
--
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
-------
P
T
S
G
D
V
L
Y
D--
G
E
--
K
G---
Y
E
I
R
------------------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
-
V
A
F
A
-
V
K
N
F
Y
P
D
R
---
D
P
V
-
P
---
L
V
K
K
A
-
M
E
F
V
G
L
D
F
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
--
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------