@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2139: (2016-05-08 )
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
Atome Classification :
(64 SA)
---------....-.....-10........20........30........40........50.-.......60.......-.70........80.-.......90.--.......100.......110........120......--.130...---------.-..---------..-------140.......150.......160.......170.......180.....-------..190---........200.---.------------.---------------..---------------------.-.210.......220.......230.......240....-...250-----.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------M
Y
P
L
-
V
R
R
L
L
-
F
LI
P
P
E
H
A
H
K
L
V
F
A
V
L
R
G
V
A
A
V
A
P
V
R
R
L
L
R
R
LLGPTD
P
V
L
A
S
T-VFGVRFPAPLGLAAGF-DKDG
T
A
L
S
SWGAMG-F
G
Y
A
E
I
G
T
V
T--AHPQPGNPAP
R
L
F
RLAD
D
R
-
A
L
L
N
RMGFNNHG
A
R
A
L
A
--
I
R
L
-
A
RH---------R-PE---------I
P
-------
I
G
V
NIGKTKKTPAGD
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
VSSPNTPG
L
R
D
-------
L
Q
A
V
----
E
S
L
R
P
I
L
S
A
V
RA---E------------T---------------ST---------------------
P
-
V
L
V
K
IAPDLSDS
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
ATN
T
T
VSR-DGLTTP-----GVDRLGPGGISG
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
RVG
D
R
L
A
L
I
S
VGGIET
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
A
K
D
I
H
E
G
I
A
R
R
L
HDGG
F
G
S
L
H
E
A
V
G
S
A
RRRQPS
88
HHSearch
94.94
100%
-102
- C2 -
4XQ6
3
PYRD_MYCTU
A:
[24-344]
-------------------------------------------
P
V
R
R
L
L
R
R
L
L
G
P
T
D
P
V
L
A
S
T
-
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
--
A
H
P
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--
I
R
L
-
A
R
H
---------
R
-
P
E
---------
I
P
-------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
-------
L
Q
A
V
----
E
S
L
R
P
I
L
S
A
V
R
A
---
E
------------
T
---------------
S
T
---------------------
P
-
V
L
V
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
-
D
G
L
T
T
P
-----
G
V
D
R
L
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
A
K
D
I
H
E
G
I
A
R
R
L
H
D
G
G
F
G
S
L
H
E
A
V
G
S
A
R
R
----
21
PsiBlast_CBE
94.82
98%
-102
- C2 -
4XQ6
5
PYRD_MYCTU
B:
[18-343]
-------------------------------------
G
S
H
M
V
A
P
V
R
R
L
L
R
R
L
L
G
P
T
D
P
V
L
A
S
T
-
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
--
A
H
P
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--
I
R
L
-
A
R
H
---------
R
-
P
E
---------
I
P
-------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
-------
L
Q
A
V
----
E
S
L
R
P
I
L
S
A
V
R
A
---
E
------------
T
---------------
S
T
---------------------
P
-
V
L
V
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
-
D
G
L
T
T
P
-----
G
V
D
R
L
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
A
K
D
I
H
E
G
I
A
R
R
L
H
D
G
G
F
G
S
L
H
E
A
V
G
S
A
R
-----
1
PsiBlast_PDB
94.55
98%
-102
- C2 -
4XQ6
3
PYRD_MYCTU
A:
[22-344]
-----------------------------------------
V
A
P
V
R
R
L
L
R
R
L
L
G
P
T
D
P
V
L
A
S
T
-
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
--
A
H
P
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--
I
R
L
-
A
R
H
---------
R
-
P
E
---------
I
P
-------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
-------
L
Q
A
V
----
E
S
L
R
P
I
L
S
A
V
R
A
---
E
------------
T
---------------
S
T
---------------------
P
-
V
L
V
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
-
D
G
L
T
T
P
-----
G
V
D
R
L
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
A
K
D
I
H
E
G
I
A
R
R
L
H
D
G
G
F
G
S
L
H
E
A
V
G
S
A
R
R
----
42
PsiBlast_CBE
77.38
43%
-85
- C2 -
3KVK
5
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
47
PsiBlast_CBE
77.20
43%
-84
- C2 -
2FPT
8
PYRD_HUMAN
A:
[48-395]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
44
PsiBlast_CBE
77.05
43%
-85
- C2 -
2FQI
8
PYRD_HUMAN
A:
[48-395]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
-
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
28
PsiBlast_CBE
76.99
43%
-86
- C2 -
4RLI
3
PYRD_HUMAN
A:
[43-389]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
----
38
PsiBlast_CBE
76.96
43%
-85
- C2 -
4JGD
12
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
11
PsiBlast_PDB
76.93
43%
-85
- C2 -
1D3H
5
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
18
PsiBlast_PDB
76.87
43%
-83
- C2 -
3FJL
6
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
105
Fugue
76.81
41%
-93
- C2 -
1D3G
6
PYRD_HUMAN
A:
[1-367]
MATGD
E
R
F
Y
A
E
H
L
-
M
P
T
L
Q
-
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
-----------
L
G
L
L
P
F
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
-F
D
K
H
G
E
A
V
D
G
L
Y
K
M
-G
F
G
F
V
E
I
G
S
V
T
PK--
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
-Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
---
H
R
-
L
R
A
---------
R
-
Q
Q
K
Q
A
K
L
T
E
D
G
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
----GLG
K
A
E
L
R
R
L
L
----
T
K
V
L
Q
E
R
D
G
L
R
R
---
V
------------
H
---------------
R
P
---------------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
-
S
-
R
P
A
---GLQGA--
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
--
R
-
40
PsiBlast_CBE
76.65
43%
-84
- C2 -
3KVM
6
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
43
PsiBlast_CBE
76.64
43%
-84
- C2 -
3KVJ
6
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
34
PsiBlast_CBE
76.48
43%
-84
- C2 -
4JTU
7
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
17
PsiBlast_PDB
76.37
43%
-84
- C2 -
3FJ6
6
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
23
PsiBlast_CBE
76.36
43%
-84
- C2 -
3ZWT
8
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
---
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
16
PsiBlast_PDB
76.33
43%
-83
- C2 -
3F1Q
6
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
39
PsiBlast_CBE
76.27
43%
-81
- C2 -
3W7R
26
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
25
PsiBlast_CBE
76.25
43%
-83
- C2 -
2B0M
3
PYRD_HUMAN
A:
[46-393]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
20
PsiBlast_PDB
76.20
43%
-85
- C2 -
3G0X
4
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
19
PsiBlast_PDB
76.17
43%
-83
- C2 -
3G0U
3
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
14
PsiBlast_PDB
76.17
43%
-84
- C2 -
2PRL
7
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
8
PsiBlast_PDB
76.17
43%
-85
- C2 -
3U2O
7
PYRD_HUMAN
A:
[48-394]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
----
36
PsiBlast_CBE
76.16
43%
-84
- C2 -
4JTS
11
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
41
PsiBlast_CBE
76.08
43%
-83
- C2 -
3KVL
6
PYRD_HUMAN
A:
[43-389]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
----
24
PsiBlast_CBE
76.04
43%
-83
- C2 -
3ZWS
8
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
--
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
32
PsiBlast_CBE
76.03
43%
-82
- C2 -
4LS1
8
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
35
PsiBlast_CBE
75.98
43%
-84
- C2 -
4JTT
11
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
27
PsiBlast_CBE
75.80
43%
-84
- C2 -
4RR4
5
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
33
PsiBlast_CBE
75.77
43%
-83
- C2 -
4LS0
13
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
37
PsiBlast_CBE
75.72
43%
-84
- C2 -
4JS3
14
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
12
PsiBlast_PDB
75.58
43%
-87
- C2 -
2BXV
5
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
-----------
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
15
PsiBlast_PDB
75.52
43%
-78
- C2 -
2PRM
2
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
86
HHSearch
75.43
42%
-95
- C2 -
4OQV
9
PYRD_HUMAN
A:
[8-363]
-----------
E
H
-
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
-
G
L
L
P
-------
R
A
R
F
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
-
R
A
R
Q
Q
K
Q
A
K
L
--
T
E
D
G
---------
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
--
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
----------------
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
LRR
V
------------
H
---------------
R
P
---------------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-
P
-
A
G
L
Q
-----
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
----
45
PsiBlast_CBE
75.29
43%
-82
- C2 -
2FPY
9
PYRD_HUMAN
A:
[48-395]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
4
PsiBlast_PDB
75.20
42%
-93
- C2 -
1UUO
4
PYRD_RAT
A:
[18-372]
---------
L
M
P
G
-
L
Q
R
L
L
----
D
P
E
S
A
H
R
L
A
V
R
V
T
S
--------
L
G
L
L
P
----
Q
D
S
D
M
L
E
V
K
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
Q
L
T
A
D
G--
L
P
-------
L
G
I
N
L
G
K
N
K
T
S
E
--
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
---------------
Q
G
K
----
T
E
L
R
H
L
L
S
K
V
L
Q
---
E
R
D
A
LKG------
T
---------------
R
K
---------------------
P
A
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-
P
-
V
G
L
Q
-----
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
---
85
HHSearch
75.09
33%
-88
- C2 -
4CQ8
3
PYRD_PLAF7
A:
[29-399]
---------
L
Y
D
I
F
L
K
F
C
L
-
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
L
G
K
Y
N
-
I
L
-------
P
Y
D
T
S
N
D
S
I
Y
A
C
T
N
-
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--
E
N
L
-
I
L
F
R
K
R
Q
E
E
D
KL
L
-
S
K
---------
H
I
-------
V
G
V
S
I
G
K
N
K
D
T
--
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
D
N
L
E
K
N
NFLWFNTTK
K
K
---------------------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
-------
S
-
F
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
31
PsiBlast_CBE
75.04
43%
-82
- C2 -
4LS2
8
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
13
PsiBlast_PDB
74.92
43%
-90
- C2 -
2PRH
4
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
----------------
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
10
PsiBlast_PDB
74.89
43%
-87
- C2 -
1D3G
6
PYRD_HUMAN
A:
[20-367]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
---
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
-----------
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
6
PsiBlast_PDB
74.87
43%
-92
- C2 -
4OQV
9
PYRD_HUMAN
A:
[17-363]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
----------------
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
----
46
PsiBlast_CBE
74.85
43%
-81
- C2 -
2FPV
9
PYRD_HUMAN
A:
[48-395]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
30
PsiBlast_CBE
74.72
43%
-82
- C2 -
4RK8
13
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
29
PsiBlast_CBE
74.70
43%
-80
- C2 -
4RKA
9
PYRD_HUMAN
A:
[43-390]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
9
PsiBlast_PDB
74.50
43%
-80
- C2 -
2WV8
6
PYRD_HUMAN
A:
[18-365]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
-------
L
Q
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
84
HHSearch
74.36
33%
-86
- C2 -
1TV5
6
PYRD_PLAF7
A:
[41-440]
---------
L
Y
D
I
F
L
K
F
C
L
-
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
L
G
K
Y
N
-
I
L
-------
P
Y
D
T
S
N
D
S
I
Y
A
C
T
N
-
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--
E
N
L
-
I
L
F
R
K
R
Q
E
E
D
KL
L
-
S
K
---------
H
I
-------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
I
D
N
L
EFLWFNTT
K
---------------
K
K
---------------------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
--------
F
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
-----
7
PsiBlast_PDB
74.22
43%
-86
- C2 -
4IGH
6
PYRD_HUMAN
A:
[17-364]
---------------------
L
L
D
P
E
S
A
H
R
L
--
A
V
R
F
T
S
L
G
L
L
P
R
---------
Q
D
S
D
M
L
E
V
R
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
K
L
T
E
D
G--
L
P
-------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
-----------
G
K
----
A
E
L
R
R
L
L
T
K
V
L
Q
---
E
------------
R
---------------
D
G
LRRVH
R
P
--------------
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
-------
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
---
5
PsiBlast_PDB
74.08
42%
-86
- C2 -
4ORI
3
PYRD_RAT
A:
[17-364]
---------------------
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
--------
L
G
L
L
P
R
A
T
F
Q
D
S
D
M
L
E
V
K
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
Q
L
T
A
D
G--
L
P
-------
L
G
I
N
L
G
K
N
K
T
S
E
--
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
-------------
Q
G
K
----
T
E
L
R
H
L
L
S
K
V
L
Q
---
E
R
D
A
LKG------
T
---------------
R
K
---------------------
P
A
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-
P
-
V
G
L
Q
-----
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
---
3
PsiBlast_PDB
73.97
42%
-91
- C2 -
1UUM
4
PYRD_RAT
A:
[18-372]
---------
L
M
P
G
-
L
Q
R
L
L
----
D
P
E
S
A
H
R
L
A
V
R
V
T
S
--------
L
G
L
L
P
R
A
T
F
Q
D
S
D
M
L
E
V
K
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
A
Q
L
T
A
D
G--
L
P
-------
L
G
I
N
L
G
K
N
K
T
S
E
--
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
----------------
Q
G
K
----
T
E
L
R
H
L
L
S
K
V
L
Q
---
E
R
D
A
LKG------
T
---------------
R
K
---------------------
P
A
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-
P
-
V
G
L
Q
-----
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
---
22
PsiBlast_CBE
73.59
42%
-90
- C2 -
1UUM
4
PYRD_RAT
B:
[18-372]
---------
L
M
P
G
-
L
Q
R
L
L
----
D
P
E
S
A
H
R
L
A
V
R
V
T
S
--------
L
G
L
L
P
R
A
T
F
Q
D
S
D
M
L
E
V
K
-
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--
H
R
L
R
A
R
Q
---------
Q
-
K
Q
AQLTADG--
L
P
-------
L
G
I
N
L
G
K
N
K
T
S
E
--
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
----------------
Q
G
K
----
T
E
L
R
H
L
L
S
K
V
L
Q
---
E
RDALKG------
T
---------------
R
K
---------------------
P
A
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-
P
-
V
G
L
Q
-----
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
---
49
PsiBlast_CBE
73.25
32%
-84
- C2 -
5DEL
5
PYRD_PLAF7
A:
[65-397]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NIMN
D
E
F
L
W
FNTTKK
K
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
------
51
PsiBlast_CBE
72.57
32%
-86
- C2 -
4ORM
4
PYRD_PLAF7
A:
[65-397]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
N
IMN
D
E
F
L
W
FNTTKKK
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
------
56
PsiBlast_CBE
72.44
32%
-82
- C2 -
4CQ8
3
PYRD_PLAF7
B:
[65-399]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
EN
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSKHI
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
LEKNNFLWFNTTKKKP-----
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
57
PsiBlast_CBE
72.37
32%
-84
- C2 -
4CQ8
3
PYRD_PLAF7
A:
[65-399]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NFLWFNTTKKK
P
-----
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
53
PsiBlast_CBE
71.93
32%
-85
- C2 -
4CQA
3
PYRD_PLAF7
A:
[65-399]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NIMNFLWFNTTKK
K
P
--
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
50
PsiBlast_CBE
71.63
32%
-93
- C2 -
4RX0
3
PYRD_PLAF7
A:
[65-398]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
----------------
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NIMN
D
E
F
L
W
FNTTKK
K
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
-----
55
PsiBlast_CBE
71.49
32%
-87
- C2 -
4CQ9
3
PYRD_PLAF7
A:
[65-399]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NFLWFNTTKK
K
P
-----
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
54
PsiBlast_CBE
71.43
32%
-86
- C2 -
4CQ9
3
PYRD_PLAF7
B:
[65-399]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
EN
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSKHI
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
LEKNNFLWFNTTKKKP-----
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
52
PsiBlast_CBE
71.25
32%
-87
- C2 -
4CQA
3
PYRD_PLAF7
B:
[65-399]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NFLWFNTTKK
K
P
-----
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
63
PsiBlast_CBE
70.84
32%
-88
* C2 *
3I65
4
PYRD_PLAF7
A:
[79-413]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
---------------
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NIMN
D
E
F
L
W
FNTTKKK
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
----
62
PsiBlast_CBE
70.58
32%
-81
- C2 -
3I68
3
PYRD_PLAF7
A:
[79-412]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NIMN
D
E
F
L
W
FNTTKK
K
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
-----
60
PsiBlast_CBE
70.55
32%
-82
- C2 -
3O8A
3
PYRD_PLAF7
A:
[79-411]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
NNIMN
D
E
F
L
W
FNTTKKK
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
------
61
PsiBlast_CBE
70.53
32%
-82
- C2 -
3I6R
3
PYRD_PLAF7
A:
[79-412]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
-------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
E
K
N
NIMN
D
E
F
L
W
FNTTKK
K
P
L
-
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
-----
48
PsiBlast_CBE
69.64
32%
-89
- C2 -
3SFK
3
PYRD_PLAF7
A:
[64-396]
-------------------------------------------------------
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
-
F
R
K
---------
R
-
Q
E
---------
E
D
KLLSK
H
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
--------------
N
Q
E
A
----
G
K
L
K
N
I
I
L
S
V
K
E
---
E
------------
I
---------------
D
N
L
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K
N
NIMN
D
E
F
L
W
FNTTKK
K
P
L
-
V
F
V
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L
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D
L
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K
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I
A
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V
L
L
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N
I
D
G
M
I
I
S
N
T
T
T
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-
N
D
I
K
S
F
-----
E
N
K
K
---
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
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M
Y
N
Y
T
N
K
Q
I
P
I
I
A
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G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
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C
L
V
F
N
G
M
K
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A
V
Q
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K
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L
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H
L
L
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Y
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N
L
K
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A
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G
R
K
------