@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2173: (2016-05-08 )
MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELAMMAANRSA
Atome Classification :
(24 SA)
----.........10........20........30........----40........50....--...----.60.-----.-...---....70..----......80........90.--.......100.......110.......120..----.....130.-.--.....140.......150....-...160...-----....170.......------------180---..------------.......190.......200.......210...--...-.220.......230.......240.......250.......260..-.....270....-...280.......-290-----.-........300.......310.......320......----.330--........340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MA
G
A
I
T
D
Q
L
R
R
Y
L
HG
R
R
R
A
A
A
HMGSDY
D
G
L
I
A
D
L
E
D
F
V
L----GGGKRLR
P
L
F
A
Y
WGWH--AVA----SR-E-----P-DP
D
---
V
L
L
L
F
S
A
L
----
E
L
L
H
A
W
A
L
V
H
D
D
L
IDRSAT--RRGRP
T
A
Q
L
R
Y
A
A
LHRDRDWRGS
P
D
Q
F
G
M
S
A
A
----
I
L
L
G
D
L
A
Q
V
-
W
--
A
D
D
I
V
S
K
V
C
Q
S
ALA
P
D
A
Q
R
R
V
H
-
R
V
W
A
D
I
R
N
E
-----VLGG
Q
Y
L
D
I
V
AE
A
S
------------
A
-----
A
E
------------
S
I
E
S
A
M
N
V
A
T
L
K
T
A
C
Y
TVSRPLQLGTAAAA
D
R
S
--
D
V
A
-
A
I
F
E
HFGADL
G
V
A
F
Q
L
R
D
D
V
L
GVFGDPAVTGKPSGDDLKSG
K
R
T
V
L
-
V
A
E
A
V
E
LADRS
D
-
P
L
A
A
K
L
L
R
T
S
IGT-R-------L-
T
D
A
Q
V
R
E
L
R
T
V
I
E
A
VGA
R
A
A
A
E
S
R
I
A
A
L
T
Q
R
A
L
A
T
L
A----SAP---IN
A
T
A
K
A
G
L
S
E
L
A
M
M
AANRSA
2
PsiBlast_PDB
93.77
42%
-81
- C1 -
3QQV
6
?
A:
[25-371]
--------
V
R
D
R
L
T
Q
F
L
D
A
Q
E
L
T
I
A
D
I
G
A
P
V
T
D
A
V
A
H
L
R
S
F
V
L
----
N
G
G
K
R
I
R
P
L
Y
A
W
A
G
F
L
--
A
A
Q
GHKN
S
S
-
E
-----
K
-
L
E
S
---
V
L
D
A
A
A
S
L
----
E
F
I
Q
A
C
A
L
I
H
D
D
I
I
D
S
S
D
T
--
R
R
G
A
P
T
V
H
R
A
V
E
A
D
H
R
A
N
N
F
E
G
D
P
E
H
F
G
V
S
V
S
----
I
L
A
G
D
M
A
L
V
-
W
--
A
E
D
M
L
Q
---
D
S
G
L
S
A
E
A
L
A
R
T
R
-
D
A
W
R
G
M
R
T
E
-----
V
I
G
G
Q
L
L
D
I
Y
L
E
S
H
------------
A
-----
N
E
------------
S
V
E
L
A
D
S
V
N
R
F
K
T
A
A
Y
T
I
A
R
P
L
H
L
G
A
S
I
A
G
G
S
P
--
Q
L
I
-
D
A
L
L
H
Y
G
H
D
I
G
I
A
F
Q
L
R
D
D
L
L
G
V
F
G
D
P
A
I
T
G
K
P
A
G
D
D
I
R
E
G
K
R
T
V
L
-
L
A
L
A
L
Q
R
A
D
K
Q
S
-
P
E
A
A
T
A
I
R
A
G
V
G
K
-
V
-------
T
-
S
P
E
D
I
A
V
I
T
E
H
I
R
A
T
G
A
E
E
E
V
E
Q
R
I
S
Q
L
T
E
S
G
L
A
H
L
D
----
D
V
D
---
I
P
D
E
V
R
A
Q
L
R
A
L
A
I
R
S
T
E
R
--
1
PsiBlast_PDB
90.60
42%
-91
- C1 -
3LK5
1
?
A:
[25-370]
--------
V
R
D
R
L
T
Q
F
L
D
A
Q
E
L
T
I
A
D
I
G
A
P
V
T
D
A
V
A
H
L
R
S
F
V
L
----
N
G
G
K
R
I
R
P
L
Y
A
W
A
G
F
L
--
A
A
Q
GHKN
S
S
-
E
-----
K
-
L
E
S
---
V
L
D
A
A
A
S
L
----
E
F
I
Q
A
C
A
L
I
H
D
D
I
I
D
S
-------------------------------
F
G
V
S
V
S
----
I
L
A
G
D
M
A
L
V
-
W
--
A
E
D
M
L
Q
---
D
S
G
L
S
A
E
A
L
A
R
T
R
-
D
A
W
R
G
M
R
T
E
-----
V
I
G
G
Q
L
L
D
I
Y
L
E
S
H
------------
A
-----
N
E
------------
S
V
E
L
A
D
S
V
N
R
F
K
T
A
A
Y
T
I
A
R
P
L
H
L
G
A
S
I
A
G
G
S
P
--
Q
L
I
-
D
A
L
L
H
Y
G
H
D
I
G
I
A
F
Q
L
R
D
D
L
L
G
V
F
G
D
P
A
I
T
G
K
P
A
G
D
D
I
R
E
G
K
R
T
V
L
-
L
A
L
A
L
Q
R
A
D
K
Q
S
-
P
E
A
A
T
A
I
R
A
G
V
G
K
-
V
-------
T
-
S
P
E
D
I
A
V
I
T
E
H
I
R
A
T
G
A
E
E
E
V
E
Q
R
I
S
Q
L
T
E
S
G
L
A
H
L
D
----
D
V
D
---
I
P
D
E
V
R
A
Q
L
R
A
L
A
I
R
S
T
E
---
32
HHSearch
86.53
44%
-97
- C1 -
3LK5
1
?
A:
[48-370]
-------------------------------
T
D
A
V
A
H
L
R
S
F
V
L
----
N
G
G
K
R
I
R
P
L
Y
A
W
A
G
F
L
--
A
A
Q
----
G
H
-
K
NSSE-
K
-
L
E
S
---
V
L
D
A
A
A
S
L
----
E
F
I
Q
A
C
A
L
I
H
D
D
I
I
D
S
-------------------------------
F
G
V
S
V
S
----
I
L
A
G
D
M
A
L
V
-
W
--
A
E
D
M
L
Q
D
S
G
---
L
S
A
E
A
L
A
R
T
R
-
D
A
W
R
G
M
R
T
E
-----
V
I
G
G
Q
L
L
D
I
Y
L
E
S
H
------------
A
-----
N
E
------------
S
V
E
L
A
D
S
V
N
R
F
K
T
A
A
Y
T
I
A
R
P
L
H
L
G
A
S
I
A
-
G
G
S
P
-
Q
L
I
-
D
A
L
L
H
Y
G
H
D
I
G
I
A
F
Q
L
R
D
D
L
L
G
V
F
G
D
P
A
I
T
G
K
P
A
G
D
D
I
R
E
G
K
R
T
V
L
-
L
A
L
A
L
Q
R
A
D
K
Q
S
-
P
E
A
A
T
A
I
R
A
G
V
G
K
-
V
-------
T
-
S
P
E
D
I
A
V
I
T
E
H
I
R
A
T
G
A
E
E
E
V
E
Q
R
I
S
Q
L
T
E
S
G
L
A
H
L
D
----
D
V
D
---
I
P
D
E
V
R
A
Q
L
R
A
L
A
I
R
S
T
E
---
39
HHSearch
70.54
29%
-87
* C1 *
1WY0
2
?
A:
[33-341]
--------------------------------
V
L
Y
E
A
A
R
H
Y
P
L
----
A
G
G
K
R
V
R
P
F
V
V
L
T
S
T
E
--
A
V
G
----
G
D
---------
P
L
R
---
A
I
Y
P
A
V
A
I
----
E
L
I
H
N
Y
S
L
V
H
D
D
I
M
D
M
D
E
T
--
R
R
G
K
P
T
V
H
R
I
----------------
W
G
V
N
M
A
----
I
L
A
G
D
L
L
F
S
-
K
--
A
F
E
A
V
A
R
A
E
---
I
P
P
E
K
K
A
R
V
L
-
E
V
I
V
K
A
S
N
E
-----
L
C
E
G
Q
A
R
D
L
E
F
E
K
K
------------
S
-----
T
V
------------
T
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
-
F
E
A
S
A
K
V
G
G
I
I
G
-
T
D
N
E
-
E
Y
I
-
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
-
V
A
H
F
F
E
N
A
D
E
----
K
D
K
Q
R
F
L
K
I
F
G
K
----------D
I
K
S
D
V
M
E
A
I
D
L
L
K
K
Y
G
S
I
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
----
I
L
P
---
K
S
-
K
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
52
HHSearch
69.23
23%
-86
- C1 -
4KK2
-
CHRDS_ARTSI (first)
A:
[37-346]
-------------------------------
R
Q
W
V
E
R
M
I
D
Y
T
V
----
P
G
G
K
M
V
R
G
Y
S
V
V
D
S
Y
Q
--
L
L
K
----
G
E
-
E
-----
L
T
D
D
E
I
F
L
S
S
A
L
G
W
C
I
----
E
W
L
Q
A
Y
F
L
V
L
D
D
I
M
D
E
S
H
T
--
R
R
G
Q
P
C
W
F
R
L
-----------------
P
K
V
G
M
----
I
A
A
N
D
G
I
L
L
-
R
N
H
V
P
R
I
L
K
K
H
F
---
R
G
K
P
Y
Y
V
D
L
V
-
D
L
F
N
E
V
E
F
Q
-----
T
A
S
G
Q
M
I
D
L
I
T
T
L
V
------------
G
EKDLS
K
Y
------------
S
L
S
I
H
R
R
I
V
Q
Y
K
T
A
Y
Y
S
F
Y
L
P
V
A
C
A
L
L
M
F
-
G
E
D
L-
D
K
H
-
V
E
V
K
N
V
L
V
E
M
G
T
Y
F
Q
V
Q
D
D
Y
L
D
C
F
G
A
P
E
V
I
G
K
-
I
G
T
D
I
E
D
F
K
C
S
W
L
-
V
V
K
A
L
E
L
A
N
E
----
E
Q
K
K
T
L
H
E
N
Y
G
K
-
K
---------
D
P
A
S
V
A
K
V
K
E
V
Y
H
T
L
N
L
Q
A
V
F
E
D
Y
E
A
T
S
Y
K
K
L
I
T
S
I
E
----
N
H
P
---
S
K
-
A
V
Q
A
V
L
K
S
F
L
G
K
I
Y
K
R
Q
K
18
PsiBlast_PDB
69.18
24%
-87
- C1 -
4KK2
-
CHRDS_ARTSI (first)
A:
[45-341]
---------------------------------------
D
Y
T
V
----
P
G
G
K
M
V
R
G
Y
S
V
V
D
S
Y
Q
--
L
L
K
----
G
E
-
E
-----
L
-
T
D
D
---
E
I
F
L
S
S
A
L
G
W
C
I
E
W
L
Q
A
Y
F
L
V
L
D
D
I
M
D
E
S
H
T
--
R
R
G
Q
P
C
-------------
W
F
R
L
P
-
K
V
G
M
I
A
A
N
D
G
I
L
L
R
N
H
V
P
R
I
-
L
--
K
K
H
F
R
G
K
P
Y
Y
V
D
L
V
D
---------
L
F
N
E
V
E
F
Q
-----
T
A
S
G
Q
M
I
D
L
I
T
T
L
V
------------
G
-----
E
K
DLSKY-------
S
L
S
I
H
R
R
I
V
Q
Y
K
T
A
Y
Y
S
F
Y
L
P
V
A
C
A
L
L
M
F
G
E
D
L
--
D
K
H
-
V
E
V
K
N
V
L
V
E
M
G
T
Y
F
Q
V
Q
D
D
Y
L
D
C
F
G
A
P
E
V
I
G
K
-
I
G
T
D
I
E
D
F
K
C
S
W
L
-
V
V
K
A
L
E
L
A
N
E
E
----
Q
K
K
T
L
H
E
N
Y
G
K
-
K
---------
D
P
A
S
V
A
K
V
K
E
V
Y
H
T
L
N
L
Q
A
V
F
E
D
Y
E
A
T
S
Y
K
K
L
I
T
S
I
E
----
N
H
P
S
K
A
V
Q
A
V
L
K
S
F
L
G
K
I
---------
4
PsiBlast_PDB
68.77
29%
-89
- C1 -
4DHD
3
?
A:
[28-325]
--------------------------------
G
L
A
E
D
F
R
E
A
V
L
YQVK
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
--
A
V
S
----
G
Q
W
R
-----
P
-------
A
L
P
A
A
A
I
V
----
E
L
I
H
N
Y
S
L
I
Y
D
D
I
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
----------------
K
A
F
G
D
N
A
A
----
I
L
V
G
----
I
-
W
--
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
---
F
A
-
K
E
V
A
E
V
I
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
A
------------
G
-----
R
S
D
P
Y
F
V
Q
A
RWREV
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
-
L
I
A
A
A
A
K
W
G
V
L
S
V
S
D
D
R
--
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
R
G
N
A
-
V
V
-
A
V
A
L
S
H
L
G
E
-
G
E
R
R
R
L
L
E
I
L
A
R
E
-
V
-------
V
-
E
E
A
D
V
R
E
A
V
A
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
----
K
I
P
---
N
N
G
T
L
K
---------------
5
PsiBlast_PDB
68.53
29%
-90
- C1 -
4GP1
3
?
A:
[28-325]
--------------------------------
G
L
A
E
D
F
R
E
A
V
L
YQVK
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
--
A
V
S
----
G
Q
W
R
-----
P
-------
A
L
P
A
A
A
I
V
----
E
L
I
H
N
Y
S
L
I
Y
D
D
I
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
----------------
K
A
F
G
D
N
A
A
----
I
L
V
G
----
I
-
W
--
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
---
F
A
-
K
E
V
A
E
V
I
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
A
------------
G
-----
R
S
D
P
Y
F
V
Q
A
RWREV
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
-
L
I
A
A
A
A
K
W
G
V
L
S
V
S
D
D
R
--
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
R
G
N
A
-
V
V
-
A
V
A
L
S
H
L
G
E
-
G
E
R
R
R
L
L
E
I
L
A
R
E
-
V
-------
V
-
E
E
A
D
V
R
E
A
V
A
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
----
K
I
P
---
N
N
G
T
L
K
---------------
49
HHSearch
68.21
25%
-85
- C1 -
3NF2
6
?
A:
[48-341]
---------------------------------------
P
A
D
G
----
D
G
G
K
A
V
R
P
A
L
A
V
L
S
A
E
--
V
T
G
----
A
A
---------
P
E
V
---
G
V
P
G
A
V
A
V
----
E
L
V
H
N
F
S
L
L
H
D
D
L
M
D
G
D
E
Q
--
R
R
H
R
D
T
V
W
K
V
----------------
H
G
P
A
Q
A
----
I
L
V
G
D
A
L
F
A
-
L
--
A
N
E
V
L
L
E
L
G
--
T
-
V
--
E
A
G
R
A
T
-
R
R
L
T
K
A
S
R
S
-----
L
I
D
G
Q
A
Q
D
I
S
Y
E
H
R
------------
D
-----
R
V
------------
S
V
E
E
C
L
E
M
E
G
N
K
T
G
A
L
-
L
A
C
A
S
S
I
G
A
V
L
G
-
G
A
D
E
-
R
T
A
-
D
T
L
E
K
Y
G
Y
H
L
G
L
A
F
Q
A
V
D
D
L
L
G
I
W
G
D
P
D
A
T
G
K
Q
T
W
S
D
L
R
Q
R
K
K
S
L
P
-
V
V
A
A
L
A
A
G
G
A
-----
A
S
E
R
L
G
E
I
L
T
A
D
A
K
ASDFAN
F
-
S
E
E
E
F
A
A
R
A
A
L
I
E
E
A
G
G
R
E
W
T
A
D
E
A
R
R
Q
H
T
I
A
I
E
A
L
D
----
A
V
D
---
M
P
D
R
V
R
D
R
F
T
A
L
A
D
F
V
V
V
---
6
PsiBlast_PDB
68.17
29%
-87
- C1 -
4GP2
5
?
A:
[28-325]
--------------------------------
G
L
A
E
D
F
R
E
A
V
L
YQVK
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
--
A
V
S
----
G
Q
W
R
-----
P
-------
A
L
P
A
A
A
I
V
----
E
L
I
H
N
Y
S
L
I
Y
D
D
I
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
----------------
K
A
F
G
D
N
A
A
----
I
L
V
G
----
I
-
W
--
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
---
F
A
-
K
E
V
A
E
V
I
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
A
------------
G
-----
R
S
D
P
Y
F
V
Q
A
RWREV
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
-
L
I
A
A
A
A
K
W
G
V
L
S
V
S
D
D
R
--
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
P
K
K
F
G
K
E
I
G
K
D
I
K
E
H
K
R
G
N
A
-
V
V
-
A
V
A
L
S
H
L
G
E
-
G
E
R
R
R
L
L
E
I
L
A
R
E
-
V
-------
V
-
E
E
A
D
V
R
E
A
V
A
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
----
K
I
P
---
N
N
G
T
L
K
---------------
45
HHSearch
66.54
31%
-85
- C1 -
4DHD
3
?
A:
[33-334]
---------------------------------
F
R
E
A
V
L
Y
Q
V
K
----
T
G
G
K
R
L
R
P
L
L
T
L
A
A
A
E
--
A
V
S
----
G
Q
---------
W
R
P
---
A
L
P
A
A
A
I
V
----
E
L
I
H
N
Y
S
L
I
Y
D
D
I
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
K
A
----------------
F
G
D
N
A
A
----
I
L
V
G
I
W
Y
R
E
-
A
--
I
E
E
A
V
L
D
T
P
--
K
-----
P
T
L
F
A
-
K
E
V
A
E
V
I
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
A
GRSD
P
Y
F
V
Q
A
RW
R
-----
E
V
------------
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
-
I
A
A
A
A
K
W
G
V
L
S
V
-
S
D
D
R
-
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
R
G
N
A
V
V
A
V
A
L
S
H
L
G
E
----
G
E
R
R
R
L
L
E
I
L
A
R
E
V
-------
V
-
E
E
A
D
V
R
E
A
V
A
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
----
K
I
P
---
N
N
----
G
T
L
K
E
L
L
D
F
I
V
A
R
--
9
PsiBlast_PDB
66.26
27%
-85
- C1 -
3LMD
-
?
A:
[44-348]
-----------
Q
V
E
E
L
L
H
------
T
E
L
S
S
G
E
D
F
L
V
D
I
V
M
H
L
T
R
----
A
G
G
K
R
F
R
P
M
F
A
L
L
A
S
E
---
F
G
----
E
K
-
P
-----
L
-
S
E
N
---
V
I
K
A
A
V
V
V
----
E
I
T
H
L
A
T
L
Y
H
D
D
V
M
D
-------------
N
A
R
---------
W
D
N
S
-------
V
A
----
I
L
A
G
D
I
L
L
A
-
H
--
A
S
G
L
M
S
Q
L
G
T
D
T
V
A
H
----------
F
A
E
T
F
G
E
-----
L
V
T
G
Q
M
R
E
T
V
G
P
R
D
------------
T
------
D
------------
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
-
L
G
A
M
H
A
G
A
A
P
--
E
H
I
-
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
V
F
T
L
P
-
V
L
Y
A
L
----
R
E
D
T
P
V
G
A
E
L
R
D
I
L
T
G
P
-
L
-------
E
-
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
----
R
L
P
----
D
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
10
PsiBlast_PDB
65.45
27%
-84
- C1 -
3Q2Q
5
?
A:
[46-350]
-----------
Q
V
E
E
L
L
H
------
T
E
L
S
S
G
E
D
F
L
V
D
I
V
M
H
L
T
R
----
A
G
G
K
R
F
R
P
M
F
A
L
L
A
S
E
---
F
G
----
E
K
-
P
-----
L
-
S
E
N
---
V
I
K
A
A
V
V
V
----
E
I
T
H
L
A
T
L
Y
H
D
D
V
M
D
E
A
---------
S
A
N
A
R
---------
W
D
N
S
-------
V
A
----
I
L
A
G
D
I
L
L
A
-
H
--
A
S
G
L
M
S
Q
L
G
T
D
T
V
A
H
----------
F
A
E
T
F
G
E
-----
L
V
T
G
Q
M
R
E
T
V
G
P
R
D
------------
T
------
D
------------
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
-
L
G
A
M
H
A
G
A
A
P
--
E
H
I
-
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
-
V
L
Y
A
L
----
R
E
D
T
P
V
G
A
E
L
R
D
I
L
T
G
P
-
L
-------
E
-
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
----
R
L
P
----
D
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
38
HHSearch
65.09
28%
-92
- C1 -
3LMD
-
?
A:
[58-348]
-------------------------------
D
F
L
V
D
I
V
M
H
L
T
R
----
A
G
G
K
R
F
R
P
M
F
A
L
L
A
S
E
--
F
G
E
----
K
P
-------
L
-
S
E
N
---
V
I
K
A
A
V
V
V
----
E
I
T
H
L
A
T
L
Y
H
D
D
V
M
D
-------------
N
A
R
----------------
W
D
N
S
V
A
----
I
L
A
G
D
I
L
L
A
-
H
--
A
S
G
L
M
S
Q
L
G
---------
T
D
T
V
-
A
H
F
A
E
T
F
G
E
-----
L
V
T
G
Q
M
R
E
T
V
G
P
R
D
------------------
T
D
------------
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
-
I
A
S
A
G
Y
L
G
A
M
H
A
-
G
A
A
P
-
E
H
I
-
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
V
F
T
L
P
-
V
L
Y
A
L
R
E
D
T
P
-----
V
G
A
E
L
R
D
I
L
T
G
P
L
-------
E
-
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
----
R
L
P
---
D
S
-
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
33
HHSearch
64.96
26%
-89
- C1 -
4LOB
4
?
A:
[57-346]
---------------------------------
V
M
S
V
S
K
H
V
V
E
----
A
G
G
K
R
M
R
P
I
M
C
L
L
A
A
R
--
A
C
D
----
L
D
-------
N
-
M
Q
N
---
A
Q
R
L
A
A
I
I
----
E
M
L
H
T
A
T
L
V
H
D
D
V
V
D
--------------------------------
W
N
N
Q
T
A
----
V
L
V
G
D
F
L
I
A
-
R
--
A
F
D
L
L
V
D
L
N
--------
N
M
T
L
L
-
K
D
F
S
T
G
T
C
E
-----
I
A
E
G
E
V
L
Q
L
Q
S
Q
H
Q
------------
P
-----
D
T
------------
T
E
E
T
Y
L
K
I
I
H
G
K
T
S
R
L
-
F
E
L
A
T
E
G
A
A
I
L
A
-
G
Q
E
--
A
Y
R
-
E
P
L
R
L
F
A
G
H
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
T
L
P
-
L
I
S
A
L
A
H
S
T
G
----
E
E
H
A
I
I
R
R
S
I
A
T
-
G
---------
G
V
D
Q
L
P
K
V
I
E
I
V
Q
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
----
I
L
P
---
D
T
-
P
Y
R
Q
A
L
I
N
L
T
R
L
A
L
H
R
I
-
34
HHSearch
63.23
29%
-105
- C1 -
3OYR
1
?
A:
[53-343]
---------------------------------
I
P
A
L
A
E
H
L
I
A
----
A
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
--
L
A
G
----
A
D
---------
N
D
H
---
F
Q
K
L
A
A
A
V
----
E
F
I
H
T
A
T
L
L
H
D
D
V
V
-----------
V
A
A
H
L
I
----------------
W
G
G
A
Q
S
----
V
L
V
G
D
F
L
F
A
-
R
--
A
F
E
L
M
V
E
T
N
--------
S
M
K
A
L
-
E
I
L
A
R
A
S
R
V
-----
I
A
E
G
E
V
L
Q
L
M
R
S
H
D
------------
L
-----
N
L
------------
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
-
F
A
A
A
S
E
A
G
A
V
S
A
-
G
V
D
V
-
A
K
S
-
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
-
L
L
L
A
I
A
R
S
G
P
----
R
E
A
E
F
W
E
R
A
I
G
------------
T
E
A
D
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
----
M
F
P
---
A
N
-
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
62
Fugue
63.14
25%
-93
- C1 -
3OYR
1
?
A:
[20-343]
KSGS
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
----
A
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
--
L
A
G
----
A
--------
D
-
N
D
H
---
F
Q
K
L
A
A
A
V
----
E
F
I
H
T
A
T
L
L
H
D
D
V
V
V
A
A
---------------------------
H
L
I
W
G
G
A
Q
S
----
V
L
V
G
D
F
L
F
A
-
R
--
A
F
E
L
M
V
E
T
--------
N
S
M
K
A
L
-
E
I
L
A
R
A
S
R
V
-----
I
A
E
G
E
V
L
Q
L
M
R
S
H
D
------------
L
-----
N
L
------------
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
-
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
--
A
K
S
-
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
----------------------
A
-
T
L
P
L
L
L
A
I
A
R
S
G
-
P
R
E
A
E
F
W
E
R
A
I
G
T
------------
E
A
D
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
----
M
F
P
---
A
N
-
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
14
PsiBlast_PDB
62.51
30%
-92
- C1 -
3OYR
1
?
A:
[46-343]
--------------------------
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
----
A
G
G
K
R
L
R
P
L
M
T
V
-------
A
A
----
A
R
-
L
-----
A
-
G
A
D
ND
H
F
Q
K
L
A
A
A
V
----
E
F
I
H
T
A
T
L
L
H
D
D
V
V
-----------
V
A
A
H
L
I
W
----------------
G
G
A
Q
S
----
V
L
V
G
D
F
L
F
A
-
R
--
A
F
E
L
M
V
E
-
T
N
S
M
K
A
L
E
I
L
A
R
A
S
-
R
V
I
A
E
------------
G
E
V
L
Q
L
M
R
S
H
D
------------
L
-----
N
L
------------
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
--
K
S
E
-
A
L
-
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
-
L
L
L
A
I
A
---
R
S
G
-
P
R
E
A
E
F
W
E
R
A
I
G
------------
T
E
A
D
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
----
M
F
P
---
A
N
D
W
R
E
A
-
L
E
E
L
A
D
F
A
V
S
R
--
46
HHSearch
62.41
23%
-69
- C1 -
1UBY
3
FPPS_CHICK
A:
[60-367]
----------------------------------
K
E
V
L
Q
Y
-
N
A
----
P
G
G
K
C
N
R
G
L
T
V
V
A
A
Y
R
--
E
L
S
----
G
P
-
G
QKD
A
E
S
-
L
R
C
---
A
L
A
V
G
W
C
I
----
E
L
F
Q
A
A
S
L
V
A
D
D
I
M
D
Q
S
L
T
--
R
R
G
Q
L
C
W
Y
K
K
----------------
E
G
V
G
L
D
----
A
I
N
D
S
F
L
L
E
S
S
--
V
Y
R
V
L
K
K
Y
C
--
R
-
Q
R
P
Y
Y
V
H
L
L
-
E
L
F
L
Q
T
A
Y
Q
-----
T
E
L
G
Q
M
L
D
L
I
T
A
P
V
SKVDL-------
S
-----
H
F
------------
S
E
E
R
Y
K
A
I
V
K
Y
K
T
A
F
Y
S
F
Y
L
P
V
A
A
A
M
Y
M
V
-
G
I
D
S
K
E
E
H
-
E
N
A
K
A
I
L
L
E
M
G
E
Y
F
Q
I
Q
D
D
Y
L
D
C
F
G
D
P
A
L
T
G
A
-
V
G
T
D
I
Q
D
N
K
C
S
W
L
-
V
V
Q
C
L
Q
R
V
T
P
----
E
Q
R
Q
L
L
E
D
N
Y
G
R
---------
K
-
E
P
E
K
V
A
K
V
K
E
L
Y
E
A
V
G
M
R
A
A
F
Q
Q
Y
E
E
S
S
Y
R
R
L
Q
E
L
I
E
----
K
H
S
---
N
R
-
L
P
K
E
I
F
L
G
L
A
Q
K
I
Y
K
R
Q
K
37
HHSearch
61.75
29%
-69
- C1 -
1WMW
-
?
A:
[26-328]
--------------------------------
L
Y
R
D
L
L
Q
D
Y
P
R
----
R
G
G
K
M
L
R
G
L
L
T
V
Y
S
A
L
--
A
H
G
----
A
P
---------
L
E
A
---
G
L
E
A
A
T
A
L
----
E
L
F
Q
N
W
V
L
V
H
D
D
I
E
D
G
S
E
E
--
R
R
G
R
P
A
L
H
R
L
----------------
H
P
M
P
L
A
----
L
N
A
G
D
A
M
H
A
-
E
--
M
W
G
L
L
A
E
G
L
---
A
R
G
L
F
P
P
E
V
L
-
L
E
F
H
E
V
V
R
R
-----
T
A
Y
G
Q
H
L
D
L
L
W
T
L
G
GT----------
F
-----
D
L
------------
R
P
E
D
Y
F
R
M
V
A
H
K
A
A
Y
Y
T
A
V
A
P
L
R
L
G
A
L
L
A
-
G
K
T
---
P
P
-
A
A
Y
E
E
G
G
L
R
L
G
T
A
F
Q
I
V
D
D
V
L
N
L
E
G
G
E
-
A
Y
G
K
E
R
A
G
D
L
Y
E
G
K
R
T
L
I
-
L
L
R
F
L
E
E
A
P
P
----
E
E
R
A
R
A
L
A
L
L
A
L
P
R
EA-----
K
-
P
E
A
E
V
G
W
L
L
E
R
L
L
A
S
R
A
L
A
W
A
K
A
E
A
K
R
L
Q
A
E
G
L
A
L
L
E
AAFQ
D
L
P
---
G
K
-
E
A
L
D
H
L
R
G
L
L
A
A
L
V
E
R
--
22
PsiBlast_CBE
29.86
31%
-38
- C1 -
1RQI
6
ISPA_ECOLI
A:
[44-250]
------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
V
S
----
T
N
-
T
-----
L
-
D
A
P
---
A
----
A
A
V
----
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
----------------
F
G
E
A
N
A
----
I
L
A
G
D
A
L
Q
T
-
L
--
A
F
S
I
L
S
----
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
HVP
L
D
-------
A
-----
L
E
------------
R
I
H
R
H
K
T
G
A
L
I
R
A
A
-------
V
R
L
G
A
L
S
A
G
D
K
G
--
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
29.82
31%
-40
- C1 -
1RQI
5
ISPA_ECOLI
B:
[44-250]
------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
V
S
----
T
N
-
T
-----
L
-
D
A
P
---
A
----
A
A
V
----
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
----------------
F
G
E
A
N
A
----
I
L
A
G
D
A
L
Q
T
-
L
--
A
F
S
I
L
S
----
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
HVP
L
D
-------
A
-----
L
E
------------
R
I
H
R
H
K
T
G
A
L
I
R
A
A
-------
V
R
L
G
A
L
S
A
G
D
K
G
--
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
27.97
31%
-34
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[43-249]
------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
V
S
----
T
N
-
T
-----
L
-
D
A
P
---
A
----
A
A
V
----
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
----------------
F
G
E
A
N
A
----
I
L
A
G
D
A
L
Q
T
-
L
--
A
F
S
I
L
S
----
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
HVP
L
D
-------
A
-----
L
E
------------
R
I
H
R
H
K
T
G
A
L
I
R
A
A
-------
V
R
L
G
A
L
S
A
G
D
K
G
--
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
27.01
31%
-37
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[43-249]
------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
V
S
----
T
N
-
T
-----
L
-
D
A
P
---
A
----
A
A
V
----
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
----------------
F
G
E
A
N
A
----
I
L
A
G
D
A
L
Q
T
-
L
--
A
F
S
I
L
S
----
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
HVP
L
D
-------
A
-----
L
E
------------
R
I
H
R
H
K
T
G
A
L
I
R
A
A
-------
V
R
L
G
A
L
S
A
G
D
K
G
--
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
------------------------------------------------------------------------------------------------------------