@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2192c: (2016-05-08 )
MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...-----....230........-240.......250.......260.......270.......280.......290......-.300.....-.-.----310----.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALSAEGSSGGSRGGSPKAEAASVP
S
W
P
Q
I
L
G
R
LTDNRDLAR
G
Q
A
A
W
A
M
D
Q
IMTGNA
R
P
A
Q
I
A
A
F
A
V
A
M
TMKAP
T
A
D
E
V
G
E
L
A
G
V
M
L
SHAHPLPADTVPDDA
V
D
V
V
GTGGDG
V
N
T
V
N
L
S
T
M
A
A
I
V
V
AAAGV
P
V
VKHGN
R
A
ASSLSG
G
A
D
T
L
E
AL
G
V
R
I
DL
G
P
D
L
V
A
R
S
L
A
E
VGI
G
F
C
FAPRFHP
S
Y
R
H
A
A
A
V
R
R
EIG
V
P
T
V
F
N
L
L
GPLTNPARPRA
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
ARR
S
-
S
V
L
V
V
HGDDG
L
D
E
LTTTT
T
S
T
I
W
R
VAAGSV
D
K
L
T
FDPAGF
G
F
A
R
A
Q
L
D
Q
LAGGDA
Q
A
N
A
-
A
A
V
R
A
V
L
GG-A-R----GPV----R
D
A
V
V
LNAA
G
A
I
V
A
HAGL
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
AAIDT
G
A
A
E
Q
L
L
A
R
W
V
R
FGRQI
13
PsiBlast_PDB
99.19
100%
-126
- C10 -
3QR9
2
TRPD_MYCTU
A:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
7
PsiBlast_PDB
99.17
100%
-125
- C10 -
4OWQ
6
TRPD_MYCTU
A:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
38
PsiBlast_CBE
99.12
100%
-122
- C10 -
3R6C
5
TRPD_MYCTU
B:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
41
PsiBlast_CBE
98.94
100%
-124
- C10 -
3QS8
5
TRPD_MYCTU
C:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
23
PsiBlast_CBE
98.90
100%
-126
- C10 -
4N5V
7
TRPD_MYCTU
B:
[23-370]
----------------------
S
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
-
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
9
PsiBlast_PDB
98.74
100%
-124
- C10 -
4OWU
7
TRPD_MYCTU
A:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
55
PsiBlast_CBE
98.72
99%
-122
- C10 -
4X58
7
TRPD_MYCTU
A:
[32-378]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
A
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
27
PsiBlast_CBE
98.71
100%
-125
- C10 -
4OWN
9
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
45
PsiBlast_CBE
98.68
100%
-120
- C10 -
3QQS
4
TRPD_MYCTU
B:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
49
PsiBlast_CBE
98.66
99%
-126
- C10 -
4X59
9
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
A
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
34
PsiBlast_CBE
98.66
100%
-123
- C10 -
3TWP
5
TRPD_MYCTU
D:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
5
PsiBlast_PDB
98.66
100%
-123
- C10 -
4OWM
5
TRPD_MYCTU
A:
[25-370]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
1
PsiBlast_PDB
98.65
100%
-124
- C10 -
4N5V
7
TRPD_MYCTU
A:
[23-370]
----------------------
S
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
-
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
39
PsiBlast_CBE
98.52
100%
-124
- C10 -
3QSA
4
TRPD_MYCTU
B:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
21
PsiBlast_CBE
98.51
100%
-124
- C10 -
4N93
5
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
-
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
25
PsiBlast_CBE
98.50
100%
-122
- C10 -
4OWU
6
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
26
PsiBlast_CBE
98.49
100%
-122
- C10 -
4OWO
7
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
28
PsiBlast_CBE
98.47
100%
-126
- C10 -
4OWM
5
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
--
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
37
PsiBlast_CBE
98.43
100%
-124
- C10 -
3R88
4
TRPD_MYCTU
B:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
--
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
17
PsiBlast_PDB
98.41
100%
-121
- C10 -
3R6C
5
TRPD_MYCTU
A:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
3
PsiBlast_PDB
98.29
100%
-122
- C10 -
4N93
6
TRPD_MYCTU
A:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
-
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
16
PsiBlast_PDB
98.28
100%
-122
- C10 -
3QSA
4
TRPD_MYCTU
A:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
14
PsiBlast_PDB
98.28
100%
-121
- C10 -
3QQS
4
TRPD_MYCTU
A:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
52
PsiBlast_CBE
98.18
99%
-123
- C10 -
4X5C
3
TRPD_MYCTU
A:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
90
HHSearch
98.14
100%
-123
- C10 -
4GIU
9
TRPD_MYCTU
A:
[24-369]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
-
4
PsiBlast_PDB
98.14
100%
-123
- C10 -
4GIU
9
TRPD_MYCTU
A:
[24-369]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
-
6
PsiBlast_PDB
98.01
100%
-124
- C10 -
4OWO
7
TRPD_MYCTU
A:
[23-370]
----------------------
S
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
32
PsiBlast_CBE
98.00
99%
-122
- C10 -
4GKM
10
TRPD_MYCTU
B:
[26-371]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
11
PsiBlast_PDB
97.84
99%
-124
- C10 -
4GKM
8
TRPD_MYCTU
A:
[26-371]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
31
PsiBlast_CBE
97.83
99%
-128
- C10 -
4M0R
2
TRPD_MYCTO
B:
[26-371]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
-----
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
-
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
18
PsiBlast_PDB
97.80
100%
-124
- C10 -
3R88
3
TRPD_MYCTU
A:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
--
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
53
PsiBlast_CBE
97.76
99%
-123
- C10 -
4X5B
3
TRPD_MYCTU
B:
[25-370]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
24
PsiBlast_CBE
97.75
100%
-122
- C10 -
4OWV
3
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
--
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
44
PsiBlast_CBE
97.71
100%
-124
- C10 -
3QQS
5
TRPD_MYCTU
C:
[24-367]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
--
33
PsiBlast_CBE
97.61
100%
-126
- C10 -
3UU1
5
TRPD_MYCTU
C:
[24-369]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
---
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
----
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
51
PsiBlast_CBE
97.48
99%
-123
- C10 -
4X5C
3
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
--
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
22
PsiBlast_CBE
97.42
100%
-129
- C10 -
4N8Q
1
TRPD_MYCTU
B:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
----
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
54
PsiBlast_CBE
97.39
99%
-119
- C10 -
4X5B
1
TRPD_MYCTU
A:
[25-370]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
8
PsiBlast_PDB
97.18
100%
-128
- C10 -
4OWS
2
TRPD_MYCTU
A:
[25-370]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
---
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
---
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
46
PsiBlast_CBE
97.03
99%
-122
- C10 -
4X5D
2
TRPD_MYCTU
B:
[25-370]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
--
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
A
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
20
PsiBlast_PDB
97.01
99%
-123
- C10 -
4X5D
3
TRPD_MYCTU
A:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
--
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
A
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
50
PsiBlast_CBE
96.65
99%
-119
- C10 -
4X59
3
TRPD_MYCTU
A:
[24-370]
-----------------------
V
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
G
---
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
A
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
12
PsiBlast_PDB
96.57
99%
-122
- C10 -
4M0R
4
TRPD_MYCTO
A:
[26-370]
------------------------
P
S
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
L
P
A
D
T
V
P
D
D
A
V
D
V
V
G
T
G
---
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
-----
L
A
E
V
M
A
-
G
V
F
A
A
R
R
S
-
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
-
A
A
V
R
A
V
L
G
G
-
A
-
R
----
G
P
V
----
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
-
92
HHSearch
77.08
34%
-117
- C10 -
4YI7
1
TRPD_ACIAD
A:
[16-358]
-----------------------
R
A
N
I
Q
Q
A
L
N
H
I
T
K
N
I
H
L
T
Q
A
Q
M
E
D
V
M
R
S
I
M
Q
G
E
A
T
E
A
Q
I
G
A
L
M
M
G
L
R
M
K
G
E
S
I
D
E
I
T
A
A
A
R
V
M
R
E
L
A
I
K
I
D
V
S
D
-
I
Q
Y
L
V
D
I
V
G
T
G
G
D
--
N
L
F
N
V
S
T
A
S
S
F
V
I
A
A
A
G
A
T
I
A
K
H
G
N
R
-------
S
S
D
L
L
E
Q
A
G
I
N
L
D
L
D
M
Q
Q
T
E
R
C
I
R
E
M
G
V
G
F
L
F
A
------
M
K
Y
A
V
G
P
R
R
E
L
G
I
R
S
I
F
N
L
L
G
P
L
T
N
P
A
G
V
K
R
F
V
I
G
V
F
S
D
E
-----
L
C
R
P
I
A
-
E
V
M
K
Q
L
G
A
E
H
V
M
V
V
H
S
K
D
G
L
D
E
I
S
L
A
S
Q
T
Y
I
A
E
L
K
N
G
E
V
T
E
W
V
L
N
P
E
D
V
N
I
P
S
Q
T
L
S
G
L
I
V
E
D
S
N
A
S
L
-
K
L
I
K
D
A
L
G
R
-
K
-
K
S
D
I
G
E
K
A
----
A
N
M
I
A
L
N
A
G
A
G
I
Y
V
S
G
L
A
-------
T
S
Y
K
Q
G
V
A
L
A
H
D
I
I
Y
G
G
Q
A
L
E
K
M
S
I
L
S
E
F
T
K
A
-
95
HHSearch
76.15
41%
-112
* C10 *
2ELC
4
TRPD_THET8
A:
[2-328]
----------------------------
D
A
V
K
K
A
I
L
G
E
V
L
E
E
E
E
A
Y
E
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
H
R
--
R
P
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
-----
W
L
A
P
M
A
-
E
A
L
E
R
L
G
A
-
R
G
L
V
V
H
G
-
E
G
A
D
E
L
V
L
-
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
-
A
L
A
R
R
L
L
K
G
-
E
E
K
----
G
P
L
----
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
A
G
K
T
-------
P
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
--
56
PsiBlast_CBE
75.35
34%
-124
- C10 -
4YI7
1
TRPD_ACIAD
A:
[18-357]
-------------------------
N
I
Q
Q
A
L
N
H
I
T
K
N
I
H
L
T
Q
A
Q
M
E
D
V
M
R
S
I
M
Q
G
E
A
T
E
A
Q
I
G
A
L
M
M
G
L
R
M
K
G
E
S
I
D
E
I
T
A
A
A
R
V
M
R
E
L
A
I
K
I
D
V
S
D
I
Q
Y
-
L
V
D
I
V
G
T
G
G
D
--
N
L
F
N
V
S
T
A
S
S
F
V
I
A
A
A
G
A
T
I
A
K
H
G
N
R
-------
S
S
D
L
L
E
Q
A
G
I
N
L
D
L
D
M
Q
Q
T
E
R
C
I
R
E
M
G
V
G
F
L
F
A
------
M
K
Y
A
V
G
P
R
R
E
L
G
I
R
S
I
F
N
L
L
G
P
L
T
N
P
A
G
V
K
R
F
V
I
G
V
-
F
S
D
EL
C
R
P
I
A
E
V
M
K
-
Q
L
G
A
E
H
----
V
M
V
V
H
S
K
D
G
L
D
E
I
S
L
A
S
Q
T
Y
I
A
E
L
K
N
G
E
V
T
E
W
V
L
N
P
E
D
V
N
I
P
S
Q
T
L
S
G
L
I
V
E
D
S
N
A
S
L
-
K
L
I
K
D
A
L
G
R
-
K
-
K
----
S
D
I
G
E
K
A
A
N
M
I
A
L
N
-
A
G
A
G
I
Y
V
S
G
L
A
T
------
S
Y
K
Q
G
V
A
L
A
H
D
I
I
Y
G
G
Q
A
L
E
K
M
S
I
L
S
E
F
T
K
--
62
PsiBlast_CBE
72.26
41%
-105
- C10 -
2ELC
4
TRPD_THET8
A:
[22-328]
------------------------------------------------
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
H
R
R
P
--
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
-----
W
L
A
P
M
A
-
E
A
L
E
R
L
G
A
-
R
G
L
V
V
H
G
-
E
G
A
D
E
L
V
L
G
E
N
R
V
V
-
E
V
G
K
G
A
Y
---
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
-
A
L
A
R
R
L
L
K
G
E
E
-
K
----
G
P
L
----
A
D
A
V
A
L
A
A
G
A
G
-------
F
Y
A
A
G
K
T
P
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
--
59
PsiBlast_CBE
72.15
41%
-103
- C10 -
2ELC
2
TRPD_THET8
D:
[22-328]
------------------------------------------------
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
H
R
R
P
--
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
-----
W
L
A
P
M
A
-
E
A
L
E
R
L
G
A
-
R
G
L
V
V
H
G
-
E
G
A
D
E
L
V
L
G
E
N
R
V
V
-
E
V
G
K
G
A
Y
---
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
-
A
L
A
R
R
L
L
K
G
E
E
-
K
----
G
P
L
----
A
D
A
V
A
L
A
A
G
A
G
-------
F
Y
A
A
G
K
T
P
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
--
60
PsiBlast_CBE
71.88
41%
-101
- C10 -
2ELC
3
TRPD_THET8
C:
[22-328]
------------------------------------------------
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
R
E
A
A
R
P
L
R
V
H
R
R
P
--
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
-----
W
L
A
P
M
A
-
E
A
L
E
R
L
G
A
-
R
G
L
V
V
H
G
-
E
G
A
D
E
L
V
L
G
E
N
R
V
V
-
E
V
G
K
G
A
Y
---
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
-
A
L
A
R
R
L
L
K
G
E
E
-
K
----
G
P
L
----
A
D
A
V
A
L
A
A
G
A
G
-------
F
Y
A
A
G
K
T
P
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
--
79
PsiBlast_CBE
69.21
32%
-108
- C10 -
3GBR
7
TRPD_SULSO
B:
[5-298]
----------------------------
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
R
E
L
A
I
K
I
---
D
V
P
N
-
A
I
D
T
A
G
T
G
G
G
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
-
P
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
S
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
-----
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
-
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
-
D
-
E
----
H
-
V
----
A
E
F
I
K
I
N
T
A
V
A
L
F
A
--------------------------------------------