@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2202c: (2016-05-08 )
MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVLA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.-...-....80........90........100.......110.......120-------........130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
A
V
TGSI
A
T
D
H
L
M
RFP
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
HRGGVAGN
M
A
F
A
I
G
VLGG
E
V
A
L
V
GAAGA-
D
F
A
-
D
Y
R
D
W
L
K
ARGVNCD
H
V
L
ISETAH
T
A
R
F
T
CTTDV
D
M
A
Q
I
A
S
FYPGAM--------SEARN
I
K
L
A
D
V
V
S
A
IGKP
E
L
V
I
I
GANDP
E
A
M
F
L
H
T
E
E
C
R
KLGLAFAA
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
VNG
A
A
Y
L
F
TNDY
E
W
D
L
L
L
SKTGWSEA
D
V
M
A
Q
I
D
L
R
V
T
TLGPKG
V
D
L
VEPDG
T
T
I
H
V
G
VVPETSQTDPTGV
G
D
A
F
R
A
G
F
LTGRSAGLGLERS
A
Q
L
G
S
L
V
A
V
L
V
L
ESTGTQ
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
AYG
E
H
A
A
A
E
I
V
AVLA
4
PsiBlast_PDB
99.56
100%
-112
- C2 -
4UBE
1
ADOK_MYCBO
A:
[11-333]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
I
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
S
Q
T
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
-
64
HHSearch
99.19
100%
-114
- C2 -
2PKF
-
ADOK_MYCTU
A:
[1-324]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
I
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
S
Q
T
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
A
1
PsiBlast_PDB
99.19
100%
-114
- C2 -
2PKF
-
ADOK_MYCTU
A:
[1-324]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
I
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
S
Q
T
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
A
2
PsiBlast_PDB
98.91
100%
-111
- C2 -
2PKK
1
ADOK_MYCTU
A:
[11-333]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
I
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
S
Q
T
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
-
3
PsiBlast_PDB
98.67
100%
-113
- C2 -
2PKN
1
ADOK_MYCTU
A:
[11-333]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
I
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
S
Q
T
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
-
5
PsiBlast_PDB
98.65
100%
-113
- C2 -
4O1G
2
ADOK_MYCTU
A:
[1-323]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
I
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
S
Q
T
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
-
6
PsiBlast_PDB
95.15
99%
-111
- C2 -
4PVV
1
ADOK_MYCTU
A:
[1-324]
M
T
I
A
V
T
G
S
I
A
T
D
H
L
M
R
F
P
G
R
F
S
E
Q
L
L
P
E
H
L
H
K
V
S
L
S
F
L
V
D
D
L
V
M
H
R
G
G
V
A
G
N
M
A
F
A
I
G
V
L
G
G
E
V
A
L
V
G
A
A
G
A
-
D
F
A
-
D
Y
R
D
W
L
K
A
R
G
V
N
C
D
H
V
L
I
S
E
T
A
H
T
A
R
F
T
C
T
T
D
V
D
M
A
Q
L
A
S
F
Y
P
G
A
M
--------
S
E
A
R
N
I
K
L
A
D
V
V
S
A
I
G
K
P
E
L
V
I
I
G
A
N
D
P
E
A
M
F
L
H
T
E
E
C
R
K
L
G
L
A
F
A
A
D
P
S
Q
Q
L
A
R
L
S
G
E
E
I
R
R
L
V
N
G
A
A
Y
L
F
T
N
D
Y
E
W
D
L
L
L
S
K
T
G
W
S
E
A
D
V
M
A
Q
I
D
L
R
V
T
T
L
G
P
K
G
V
D
L
V
E
P
D
G
T
T
I
H
V
G
V
V
P
E
T
---
D
P
T
G
V
G
D
A
F
R
A
G
F
L
T
G
R
S
A
G
L
G
L
E
R
S
A
Q
L
G
S
L
V
A
V
L
V
L
E
S
T
G
T
Q
E
W
Q
W
D
Y
E
A
A
A
S
R
L
A
G
A
Y
G
E
H
A
A
A
E
I
V
A
V
L
A
9
PsiBlast_PDB
71.42
35%
-96
- C2 -
3B1P
3
?
A:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
27
PsiBlast_CBE
71.33
35%
-97
- C2 -
3B1R
5
?
E:
[10-316]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
22
PsiBlast_CBE
71.23
35%
-99
- C2 -
3B1Q
14
?
E:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
------
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
23
PsiBlast_CBE
71.18
35%
-96
- C2 -
3B1Q
1
?
D:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
------------
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
8
PsiBlast_PDB
71.16
35%
-98
- C2 -
3B1O
-
?
A:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
65
HHSearch
70.93
35%
-94
- C2 -
3B1N
5
?
A:
[2-312]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
-
V
D
A
Q
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
--------
M
Q
---
S
H
V
N
H
A
-
G
E
A
K
D
I
K
L
A
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
-
G
T
E
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
Y
R
P
K
--------
25
PsiBlast_CBE
70.85
35%
-98
- C2 -
3B1N
6
?
B:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
10
PsiBlast_PDB
70.65
35%
-97
- C2 -
3B1Q
8
?
A:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
-------
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
29
PsiBlast_CBE
70.63
35%
-95
- C2 -
3B1R
5
?
C:
[10-316]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
26
PsiBlast_CBE
70.50
35%
-95
- C2 -
3B1R
4
?
F:
[10-316]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
7
PsiBlast_PDB
70.44
35%
-95
- C2 -
3B1N
5
?
A:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
24
PsiBlast_CBE
70.10
35%
-96
- C2 -
3B1Q
7
?
B:
[2-308]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
------
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------
28
PsiBlast_CBE
70.07
35%
-94
- C2 -
3B1R
5
?
D:
[10-316]
-
A
T
L
I
C
G
S
I
A
Y
D
N
I
M
T
F
E
G
R
F
R
E
H
I
L
P
D
Q
V
H
L
I
N
L
S
F
L
V
P
T
M
R
R
E
F
G
G
C
A
G
N
I
A
Y
A
L
N
L
L
G
G
D
A
R
M
M
G
T
L
G
A
V
D
A
Q
-
P
Y
L
D
R
M
D
A
L
G
L
S
R
E
Y
V
R
V
L
P
D
T
Y
S
A
Q
A
M
I
T
T
D
L
D
N
N
Q
I
T
A
F
H
P
G
A
M
MQSHVNHA
G
E
A
K
D
I
K
L
A
------------
I
V
G
P
D
G
F
Q
G
M
V
Q
H
T
E
E
L
A
Q
A
G
V
P
F
I
F
D
P
G
Q
G
L
P
L
F
D
G
A
T
L
R
R
S
I
E
L
A
T
Y
I
A
V
N
D
Y
E
A
K
L
V
C
D
K
T
G
W
S
E
D
E
I
A
S
R
V
Q
A
L
I
I
T
R
G
E
H
G
A
T
I
R
H
R
D
G
T
E
-
Q
I
P
A
V
R
A
E
R
V
I
D
P
T
G
C
G
D
A
F
R
G
G
L
L
Y
G
I
E
H
G
F
D
W
A
T
A
G
R
L
A
S
L
M
G
A
L
K
I
A
H
Q
G
P
Q
T
Y
A
P
T
R
A
E
I
D
A
R
F
E
T
A
F
G
------------