@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2246: (2016-05-09 )
MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTALATDAETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLTRIELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAEELVFSYDDMRARGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAIARAWQQIVLGEADAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIETEEHAKARGANILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGDLAEGRAINNALGGNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLVNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY
Atome Classification :
(39 SA)
.........10........20........30........40........50........60...--.....70....---....80--------------......-...--90--.---.......100-.......110.......--120--..--.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350--..--..----...360.......370.......380.......390.......400....-..-.410.-......420.......430......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGVPPLAGASRTDMEGTFAR
P
M
T
E
L
VTGKAF
P
Y
V
V
V
TG
I
A
M
T
T
ALATDA
E
T
T
W
K
L
LLDRQSGIR--TLD
D
P
F
V
E
EFD---L
P
V
R
I
---------------
G
G
H
L
L
E
-
E
F
D
--
H
Q
--
L
---
T
R
I
E
L
R
R
M
G
Y
-
L
Q
R
M
S
T
V
L
S
R
R
L
W
ENAG--SPE--VD--T
N
R
L
M
V
S
IGTGLG
S
A
E
E
L
V
F
S
Y
D
D
M
R
ARGMKAVSP
L
T
V
Q
K
YMPNGA
A
A
A
VG
L
E
R
HAKAGV
M
T
P
V
S
A
C
A
S
G
A
E
A
I
A
R
A
W
Q
Q
I
VLGEA
D
A
A
I
CGGVE
T
R
I
E
A
VPIAG
F
A
Q
M
R
I
V
M
STNNDDPAGACRPFDRDRD
G
F
V
FGEG
G
A
L
L
L
I
E
T
E
E
HAKAR
G
A
N
I
L
A
R
I
MGASITSDG
F
H
M
VAPDPNG
E
R
A
G
H
A
I
T
R
A
I
Q
L
AGLAPGDIDHVNAHATGTQVGDLAEGRAINNALG--GN--RP----
A
V
YA
P
K
S
ALGHSVG
A
V
G
A
V
E
S
I
L
T
V
L
A
L
RDQVIPPTL
N
L
V
NLDPEI
D
L
D
V
-VA-GEPRP-G
N
Y
R
Y
A
INNSFGFGG
H
N
V
A
I
A
FGRY
115
HHSearch
98.49
100%
-91
- C3 -
2GP6
-
FAB2_MYCTU
A:
[6-417]
--------------------------
T
G
K
A
F
P
Y
V
V
V
T
G
I
A
M
T
T
A
L
A
T
D
A
E
T
T
W
K
L
L
L
D
R
Q
S
G
I
R
--
T
L
D
D
P
F
V
E
E
F
D
---
L
P
V
R
I
---------------
G
G
H
L
L
E
-
E
F
D
--
H
Q
--
L
---
T
R
I
E
L
R
R
M
G
Y
-
L
Q
R
M
S
T
V
L
S
R
R
L
W
E
N
A
G
--
S
P
E
--
V
D
--
T
N
R
L
M
V
S
I
G
T
G
L
G
S
A
E
E
L
V
F
S
Y
D
D
M
R
A
R
G
M
K
A
V
S
P
L
T
V
Q
K
Y
M
P
N
G
A
A
A
A
V
G
L
E
R
H
A
K
A
G
V
M
T
P
V
S
A
C
A
S
G
A
E
A
I
A
R
A
W
Q
Q
I
V
L
G
E
A
D
A
A
I
C
G
G
V
E
T
R
I
E
A
V
P
I
A
G
F
A
Q
M
R
I
V
M
S
T
N
N
D
D
P
A
G
A
C
R
P
F
D
R
D
R
D
G
F
V
F
G
E
G
G
A
L
L
L
I
E
T
E
E
H
A
K
A
R
G
A
N
I
L
A
R
I
M
G
A
S
I
T
S
D
G
F
H
M
V
A
P
D
P
N
G
E
R
A
G
H
A
I
T
R
A
I
Q
L
A
G
L
A
P
G
D
I
D
H
V
N
A
H
A
T
G
T
Q
V
G
D
L
A
E
G
R
A
I
N
N
A
L
G
--
G
N
--
R
P
----
A
V
Y
A
P
K
S
A
L
G
H
S
V
G
A
V
G
A
V
E
S
I
L
T
V
L
A
L
R
D
Q
V
I
P
P
T
L
N
L
V
N
L
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
P
-
G
N
Y
R
Y
A
I
N
N
S
F
G
F
G
G
H
N
V
A
I
A
F
G
R
Y
1
PsiBlast_PDB
98.33
99%
-92
- C3 -
2GP6
-
FAB2_MYCTU
A:
[3-417]
-----------------------
H
M
V
T
G
K
A
F
P
Y
V
V
V
T
G
I
A
M
T
T
A
L
A
T
D
A
E
T
T
W
K
L
L
L
D
R
Q
S
G
I
R
--
T
L
D
D
P
F
V
E
E
F
D
---
L
P
V
R
I
---------------
G
G
H
L
L
E
-
E
F
D
--
H
Q
--
L
---
T
R
I
E
L
R
R
M
G
Y
-
L
Q
R
M
S
T
V
L
S
R
R
L
W
E
N
A
G
--
S
P
E
--
V
D
--
T
N
R
L
M
V
S
I
G
T
G
L
G
S
A
E
E
L
V
F
S
Y
D
D
M
R
A
R
G
M
K
A
V
S
P
L
T
V
Q
K
Y
M
P
N
G
A
A
A
A
V
G
L
E
R
H
A
K
A
G
V
M
T
P
V
S
A
C
A
S
G
A
E
A
I
A
R
A
W
Q
Q
I
V
L
G
E
A
D
A
A
I
C
G
G
V
E
T
R
I
E
A
V
P
I
A
G
F
A
Q
M
R
I
V
M
S
T
N
N
D
D
P
A
G
A
C
R
P
F
D
R
D
R
D
G
F
V
F
G
E
G
G
A
L
L
L
I
E
T
E
E
H
A
K
A
R
G
A
N
I
L
A
R
I
M
G
A
S
I
T
S
D
G
F
H
M
V
A
P
D
P
N
G
E
R
A
G
H
A
I
T
R
A
I
Q
L
A
G
L
A
P
G
D
I
D
H
V
N
A
H
A
T
G
T
Q
V
G
D
L
A
E
G
R
A
I
N
N
A
L
G
--
G
N
--
R
P
----
A
V
Y
A
P
K
S
A
L
G
H
S
V
G
A
V
G
A
V
E
S
I
L
T
V
L
A
L
R
D
Q
V
I
P
P
T
L
N
L
V
N
L
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
P
-
G
N
Y
R
Y
A
I
N
N
S
F
G
F
G
G
H
N
V
A
I
A
F
G
R
Y
121
HHSearch
86.63
64%
-86
- C3 -
4C72
17
?
A:
[27-439]
-----------------------
P
S
T
A
N
G
G
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
-
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
---
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
3
PsiBlast_PDB
86.30
66%
-84
- C3 -
2WGE
10
FAB1_MYCTU
A:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
24
PsiBlast_CBE
86.07
66%
-84
- C3 -
4C70
8
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
11
PsiBlast_PDB
85.99
66%
-83
- C3 -
4C72
17
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
35
PsiBlast_CBE
85.86
66%
-84
- C3 -
2WGF
1
FAB1_MYCTU
H:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
27
PsiBlast_CBE
85.69
66%
-83
- C3 -
4C6W
6
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
33
PsiBlast_CBE
85.61
66%
-84
- C3 -
2WGG
5
FAB1_MYCTU
C:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
23
PsiBlast_CBE
85.56
66%
-83
- C3 -
4C71
9
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
10
PsiBlast_PDB
85.56
66%
-83
- C3 -
4C71
12
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
2
PsiBlast_PDB
85.56
66%
-86
- C3 -
2WGD
5
FAB1_MYCTU
A:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
13
PsiBlast_PDB
85.54
66%
-84
- C3 -
2WGF
3
FAB1_MYCTU
A:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
25
PsiBlast_CBE
85.52
66%
-84
- C3 -
4C6Z
9
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
14
PsiBlast_PDB
85.51
66%
-85
- C3 -
2WGG
7
FAB1_MYCTU
A:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
31
PsiBlast_CBE
85.50
66%
-83
- C3 -
2WGG
1
FAB1_MYCTU
E:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
7
PsiBlast_PDB
85.48
66%
-83
- C3 -
4C6X
6
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
21
PsiBlast_CBE
85.46
66%
-83
- C3 -
4C73
13
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
12
PsiBlast_PDB
85.46
66%
-83
- C3 -
4C73
19
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
32
PsiBlast_CBE
85.38
66%
-85
- C3 -
2WGG
5
FAB1_MYCTU
D:
[11-416]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
9
PsiBlast_PDB
85.33
66%
-83
- C3 -
4C70
9
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
6
PsiBlast_PDB
85.27
66%
-82
- C3 -
4C6W
3
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
22
PsiBlast_CBE
85.17
66%
-83
- C3 -
4C72
14
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
8
PsiBlast_PDB
84.90
66%
-82
- C3 -
4C6Z
9
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
26
PsiBlast_CBE
84.69
66%
-83
- C3 -
4C6X
4
?
B:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
4
PsiBlast_PDB
84.44
66%
-82
- C3 -
4C6U
6
?
A:
[34-439]
------------------------------
F
P
S
V
V
V
T
A
V
T
A
T
T
S
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
H
--
A
L
E
D
E
F
V
T
K
W
D
---
L
A
V
K
I
---------------
G
G
H
L
K
D
-
P
V
D
--
S
H
--
M
---
G
R
L
D
M
R
R
M
S
Y
-
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
--
S
P
E
--
V
D
--
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
-
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
-
G
--
C
D
--
Q
A
----
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
I
D
L
D
V
-
V
A
-
G
E
P
R
Y
-
G
D
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
45
PsiBlast_CBE
72.84
35%
-71
- C3 -
4LS7
6
FABF_BACSU
B:
[19-424]
---------------------------------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
--
P
I
T
R
V
D
A
E
E
Y
-----
P
A
K
V
---------------
A
A
E
L
K
D
F
N
V
E
--
D
Y
--
M
---
D
K
K
E
A
R
K
M
D
R
-
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
--
L
N
I
--
T
D
EI
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
--
S
T
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
EH
A
H
--
K
L
----
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
-
V
P
-
D
E
A
R
R
-
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
44
PsiBlast_CBE
72.51
35%
-69
- C3 -
4LS8
9
FABF_BACSU
A:
[19-424]
---------------------------------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
--
P
I
T
R
V
D
A
E
E
Y
-----
P
A
K
V
---------------
A
A
E
L
K
D
F
N
V
E
--
D
Y
--
M
---
D
K
K
E
A
R
K
M
D
R
-
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
--
L
N
I
--
T
D
EI
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
--
S
T
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
EH
A
H
--
K
L
----
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
-
V
P
-
D
E
A
R
R
-
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
43
PsiBlast_CBE
72.31
35%
-69
- C3 -
4LS8
5
FABF_BACSU
B:
[19-424]
---------------------------------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
--
P
I
T
R
V
D
A
E
E
Y
-----
P
A
K
V
---------------
A
A
E
L
K
D
F
N
V
E
--
D
Y
--
M
---
D
K
K
E
A
R
K
M
D
R
-
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
--
L
N
I
--
T
D
EI
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
--
S
T
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
EH
A
H
--
K
L
----
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
-
V
P
-
D
E
A
R
R
-
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
72
PsiBlast_CBE
72.30
36%
-76
- C3 -
3I8P
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
73
PsiBlast_CBE
72.27
36%
-76
- C3 -
3HO9
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
74
PsiBlast_CBE
71.66
36%
-76
- C3 -
3HO2
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
81
PsiBlast_CBE
71.53
36%
-75
- C3 -
3G11
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
82
PsiBlast_CBE
70.85
36%
-76
- C3 -
3G0Y
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
75
PsiBlast_CBE
70.85
36%
-73
- C3 -
3HNZ
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
83
PsiBlast_CBE
70.71
36%
-74
- C3 -
2GFX
1
FABF_ECOLI
A:
[20-426]
---------------------------------
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
--
L
I
D
-----
H
F
D
TSA
Y
A
T
K
F
---------------
A
G
-
L
V
K
-
D
F
N
--
C
E
DI
I
---
S
R
K
E
Q
R
K
M
D
A
-
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
E
I
T
E
--
E
N
--
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
-
A
L
S
T
R
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
EA
A
S
--
R
V
----
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
F
-
V
P
-
H
E
A
R
Q
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
-
63
PsiBlast_CBE
70.51
36%
-76
- C3 -
2IX4
3
KASM_ARATH
A:
[3-428]
---------------------------------
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
G
L
T
L
D
D
L
K
M
K
S
F
D
---
E
E
T
K
L
Y
T
F
D
Q
LSSK
V
A
A
F
V
P
Y
G
S
N
P
G
-
E
F
D
--
E
A
--
L
WLN
S
K
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
--
L
P
--
T
E
E
--
E
E
--
K
E
R
T
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
K
F
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
Q
S
G
L
C
P
N
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
--
E
H
--
A
T
S
GT
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
K
R
F
-
M
P
L
T
T
S
K
K
-
M
L
V
R
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
---
62
PsiBlast_CBE
70.45
36%
-77
- C3 -
2IX4
3
KASM_ARATH
B:
[3-428]
---------------------------------
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
GL
T
L
D
D
L
K
M
K
S
F
D
---
E
E
T
K
L
YTFDQLSSKVAAFVP
Y
G
S
N
P
G
-
E
F
D
--
E
A
--
L
WLN
S
K
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
--
L
P
--
T
E
E
--
E
E
--
K
E
R
T
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
K
F
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
Q
S
G
L
C
P
N
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
--
E
H
--
A
T
SGTL
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
K
R
F
-
M
P
L
T
T
S
K
K
-
M
L
V
R
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
---
123
HHSearch
67.84
32%
-66
- C3 -
3MQD
4
?
A:
[22-426]
------------------------------
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
I
S
--
R
A
E
E
Y
A
--
E
L
G
---
F
R
C
Q
V
---------------
H
G
--
A
P
-
D
I
D
IE
S
L
--
V
---
D
R
R
A
M
R
F
H
G
R
-
G
T
A
W
N
H
I
A
M
D
Q
A
I
A
D
A
G
--
L
T
E
E
E
V
S
--
N
E
R
T
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
-
L
S
V
L
F
D
A
M
G
A
M
S
S
K
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
--
M
V
A
P
S
G
E
G
A
I
R
C
M
K
M
A
L
S
T
V
---
T
S
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
--
A
G
DV
C
P
----
P
I
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
P
A
F
A
D
M
P
I
V
R
-
K
R
I
D
N
-
V
Q
L
N
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y