@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2247: (2016-05-09 )
MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
Atome Classification :
(22 SA)
.........10--........20........30.....---------------.---------------..40------------.........50........60........70........80........90........100.......110.......120.......130.......140.......150..-.....160.......170.......180.......190.......200.......210.......220..---.------------..------.-----..230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......-430.......440.......450.......460...-----....470.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTIMA
P
E
A
VGE--SLDPR
D
P
L
L
R
L
S
NFFDDG
S
V
E
L
L
H
E---------------R---------------DRS-------------
G
V
L
A
AAGTVNG
V
R
T
I
A
F
CTDG
T
V
MGGAMG
V
E
G
C
T
H
I
V
N
A
Y
D
TAIEDQS
P
I
V
G
I
WHSG
G
A
R
L
A
E
G
V
R
A
L
H
A
V
G
Q
V
F
E
A
M
I
R
ASGYI
P
Q
I
S
V
V
V
G
FAAGGAAYGPA
L
T
D
V
V
V
MAPE-
S
R
V
F
V
T
G
P
D
V
V
R
SVTGEDVDMASLGGPETHHKKS
G
V
C
H
I
V
ADDEL
D
A
Y
D
RG
R
R
L
V
G
L
F
CQQGHFDRS-KA---E------------AG------D-----T
D
I
H
A
LLPESSRRAY
D
V
R
P
I
V
T
A
I
LDADT
P
F
D
E
FQANWA
P
S
M
V
V
G
L
GRLSG
R
T
V
G
V
LANN
P
L
R
L
G
GCLN
S
E
S
A
E
K
A
A
R
F
V
R
L
C
D
AFG
I
P
L
V
V
V
V
DVPGYLPGV
D
Q
E
W
G
G
V
V
R
R
G
A
K
L
L
H
A
F
GECTV
P
R
V
T
L
V
T
RKTYG
G
A
Y
I
A
M
NSRSLN
A
T
K
V
F
AWPDA
E
V
A
V
MG
A
K
A
A
V
G
I
L
H
K
K
K
LAAAP
E
H
E
R
E
A
L
H
D
Q
L
A
A
E
H
E
R
IA-GGVDSALDIGVVDEKID
P
A
H
T
R
S
K
L
T
E
A
L
A
Q
A
P
A
RR-----GRHKNIPL
21
PsiBlast_CBE
98.62
100%
-105
- C2 -
4G2R
4
PCC6_MYCTO
B:
[14-466]
---------------
D
P
R
D
P
L
L
R
L
S
N
F
F
D
D
G
S
V
E
L
L
H
E
---------------
R
---------------
D
R
S
-------------
G
V
L
A
A
A
G
T
V
N
G
V
R
T
I
A
F
C
T
D
G
T
V
M
G
G
A
M
G
V
E
G
C
T
H
I
V
N
A
Y
D
T
A
I
E
D
Q
S
P
I
V
G
I
W
H
S
G
G
A
R
L
A
E
G
V
R
A
L
H
A
V
G
Q
V
F
E
A
M
I
R
A
S
G
Y
I
P
Q
I
S
V
V
V
G
F
A
A
G
G
A
A
Y
G
P
A
L
T
D
V
V
V
M
A
P
E
-
S
R
V
F
V
T
G
P
------------
M
A
S
L
G
G
P
E
T
H
H
K
K
S
G
V
C
H
I
V
A
D
D
E
L
D
A
Y
D
R
G
R
R
L
V
G
L
F
C
Q
Q
G
H
F
D
R
S
-
K
A
---
E
------------
A
G
------
D
-----
T
D
I
H
A
L
L
P
E
S
S
R
R
A
Y
D
V
R
P
I
V
T
A
I
L
D
A
D
T
P
F
D
E
F
Q
A
N
W
A
P
S
M
V
V
G
L
G
R
L
S
G
R
T
V
G
V
L
A
N
N
P
L
R
L
G
G
C
L
N
S
E
S
A
E
K
A
A
R
F
V
R
L
C
D
A
F
G
I
P
L
V
V
V
V
D
V
P
G
Y
L
P
G
V
D
Q
E
W
G
G
V
V
R
R
G
A
K
L
L
H
A
F
G
E
C
T
V
P
R
V
T
L
V
T
R
K
T
Y
G
G
A
Y
I
A
M
N
S
R
S
L
N
A
T
K
V
F
A
W
P
D
A
E
V
A
V
M
G
A
K
A
A
V
G
I
L
H
K
K
K
L
A
A
A
P
E
H
E
R
E
A
L
H
D
Q
L
A
A
E
H
E
R
I
A
-
G
G
V
D
S
A
L
D
I
G
V
V
D
E
K
I
D
P
A
H
T
R
S
K
L
T
E
A
L
A
Q
A
P
A
R
R
-----
G
-------
1
PsiBlast_PDB
93.23
100%
-112
- C2 -
4L6W
-
PCC6_MYCTU
A:
[15-463]
----------------
P
R
D
P
L
L
R
L
S
N
F
F
D
D
G
S
V
E
L
L
H
E
---------------
R
---------------
D
R
S
-------------
G
V
L
A
A
A
G
T
V
N
G
V
R
T
I
A
F
C
T
D
G
T
V
M
G
G
A
M
G
V
E
G
C
T
H
I
V
N
A
Y
D
T
A
I
E
D
Q
S
P
I
V
G
I
W
H
S
G
G
A
R
L
A
E
G
V
R
A
L
H
A
V
G
Q
V
F
E
A
M
I
R
A
S
G
Y
I
P
Q
I
S
V
V
V
G
F
A
A
G
G
A
A
Y
G
P
A
L
T
D
V
V
V
M
A
P
E
-
S
R
V
F
V
T
G
P
D
V
V
R
S
V
T
G
E
D
V
D
M
A
S
L
G
G
P
E
T
H
H
K
K
S
G
V
C
H
I
V
A
D
D
E
L
D
A
Y
D
R
G
R
R
L
V
G
L
F
C
Q
Q
G
H
F
D
R
S
-
K
A
---
E
------------
A
G
------
D
-----
T
D
I
H
A
L
L
P
E
S
S
R
R
A
Y
D
V
R
P
I
V
T
A
I
L
D
A
D
T
P
F
D
E
F
Q
A
N
W
A
P
S
M
V
V
G
L
G
R
L
S
G
R
T
V
G
V
L
A
N
N
P
L
R
L
G
G
C
L
N
S
E
S
A
E
K
A
A
R
F
V
R
L
C
D
A
F
G
I
P
L
V
V
V
V
D
V
P
G
Y
L
------
W
G
G
V
V
R
R
G
A
K
L
L
H
A
F
G
E
C
T
V
P
R
V
T
L
V
T
R
K
T
Y
G
G
A
Y
I
A
M
N
S
R
S
L
N
A
T
K
V
F
A
W
P
D
A
E
V
A
V
M
G
A
K
A
A
V
--------------------------------
G
G
V
D
S
A
L
D
I
G
V
V
D
E
K
I
D
P
A
H
T
R
S
K
L
T
E
A
L
A
Q
A
P
A
---------------
45
HHSearch
92.20
100%
-110
- C2 -
4L6W
-
PCC6_MYCTU
A:
[15-463]
----------------
P
R
D
P
L
L
R
L
S
N
F
F
D
D
G
S
V
E
L
L
H
E
---------------
R
---------------
D
R
S
-------------
G
V
L
A
A
A
G
T
V
N
G
V
R
T
I
A
F
C
T
D
G
T
V
M
G
G
A
M
G
V
E
G
C
T
H
I
V
N
A
Y
D
T
A
I
E
D
Q
S
P
I
V
G
I
W
H
S
G
G
A
R
L
A
E
G
V
R
A
L
H
A
V
G
Q
V
F
E
A
M
I
R
A
S
G
Y
I
P
Q
I
S
V
V
V
G
F
A
A
G
G
A
A
Y
G
P
A
L
T
D
V
V
V
M
A
P
E
-
S
R
V
F
V
T
G
P
D
V
V
R
S
V
T
G
E
D
V
D
M
A
S
L
G
G
P
E
T
H
H
K
K
S
G
V
C
H
I
V
A
D
D
E
L
D
A
Y
D
R
G
R
R
L
V
G
L
F
C
Q
Q
G
H
F
D
R
S
-
K
A
---
E
------------
A
G
------
D
-----
T
D
I
H
A
L
L
P
E
S
S
R
R
A
Y
D
V
R
P
I
V
T
A
I
L
D
A
D
T
P
F
D
E
F
Q
A
N
W
A
P
S
M
V
V
G
L
G
R
L
S
G
R
T
V
G
V
L
A
N
N
P
L
R
L
G
G
C
L
N
S
E
S
A
E
K
A
A
R
F
V
R
L
C
D
A
F
G
I
P
L
V
V
V
V
D
V
P
G
Y
L
------
W
G
G
V
V
R
R
G
A
K
L
L
H
A
F
G
E
C
T
V
P
R
V
T
L
V
T
R
K
T
Y
G
G
A
Y
I
A
M
N
S
R
S
L
N
A
T
K
V
F
A
W
P
D
A
E
V
A
V
M
G
A
K
A
A
V
-------------------------------G
G
V
D
-
S
A
L
D
I
G
V
V
D
E
K
I
D
P
A
H
T
R
S
K
L
T
E
A
L
A
Q
A
P
A
---------------
2
PsiBlast_PDB
87.51
100%
-104
- C2 -
4FB8
-
PCC6_MYCTO
A:
[14-470]
---------------
D
P
R
D
P
L
L
R
L
S
N
F
F
D
D
G
S
V
E
L
L
H
E
---------------
R
---------------
D
R
S
-------------
G
V
L
A
A
A
G
T
V
N
G
V
R
T
I
A
F
C
T
D
G
T
V
M
G
G
A
M
G
V
E
G
C
T
H
I
V
N
A
Y
D
T
A
I
E
D
Q
S
P
I
V
G
I
W
H
S
G
G
A
R
L
A
E
G
V
R
A
L
H
A
V
G
Q
V
F
E
A
M
I
R
A
S
G
Y
I
P
Q
I
S
V
V
V
G
F
A
A
G
G
A
A
Y
G
P
A
L
T
D
V
V
V
M
A
P
E
-
S
R
V
F
V
T
G
---------------
S
L
G
G
P
E
T
H
H
K
K
S
G
V
C
H
I
V
A
D
D
E
L
D
A
Y
D
R
G
R
R
L
V
G
L
F
C
Q
Q
G
H
F
D
R
S
-
K
A
---
E
------------
A
G
------
D
-----
T
D
I
H
A
L
L
P
E
S
S
R
R
A
Y
D
V
R
P
I
V
T
A
I
L
D
A
D
T
P
F
D
E
F
Q
A
N
W
A
P
S
M
V
V
G
L
G
R
L
S
G
R
T
V
G
V
L
A
N
N
P
L
R
L
G
G
C
L
N
S
E
S
A
E
K
A
A
R
F
V
R
L
C
D
A
F
G
I
P
L
V
V
V
V
D
V
P
G
Y
L
---
D
Q
E
W
G
G
V
V
R
R
G
A
K
L
L
H
A
F
G
E
C
T
V
P
R
V
T
L
V
T
R
K
T
Y
G
G
A
Y
I
A
M
N
S
R
S
L
N
A
T
K
V
F
A
W
P
D
A
E
V
A
V
M
G
A
K
A
A
V
G
I
L
H
K
K
K
L
A
A
A
P
E
H
E
R
E
A
L
H
D
Q
----
H
E
R
I
A
-
G
G
V
D
S
A
L
D
I
G
V
V
D
E
K
I
D
P
A
H
T
R
S
K
L
T
E
A
L
A
Q
A
P
A
R
R
-----
G
R
H
K
N
---
54
HHSearch
83.61
44%
-92
- C2 -
3IAV
6
?
A:
[35-530]
------
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FARHRSTNFGLDANR
P
---------------
Y
G
D
-------------
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
L
S
E
P
P
A
F
P
---
E
E
A
DLAVT-----
D
E
------
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
-
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
D
-
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
L
N
P
Y
-
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
9
PsiBlast_PDB
82.34
43%
-93
- C2 -
3MFM
-
?
C:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
FPE
E
------------
A
D
LAVTDE
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
N
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
ESLPP
K
K
H
G
N
I
P
L
44
HHSearch
82.25
42%
-92
- C2 -
2BZR
-
PCC5_MYCTU
A:
[45-548]
-----
E
D
A
V
E
K
V
H
A
K
G
K
L
T
A
R
E
R
I
Y
A
L
L
D
E
D
S
F
V
E
L
D
A
---------------
L
AKHRSTNFNLGEKRP
L
G
D
-------------
G
V
V
T
G
Y
G
T
I
D
G
R
D
V
C
I
F
S
Q
D
A
T
V
F
G
G
S
L
G
E
V
Y
G
E
K
I
V
K
V
Q
E
L
A
I
K
T
G
R
P
L
I
G
I
N
D
G
A
G
A
R
I
Q
E
G
V
V
S
L
G
L
Y
S
R
I
F
R
N
N
I
L
A
S
G
V
I
P
Q
I
S
L
I
M
G
A
A
A
G
G
H
V
Y
S
P
A
L
T
D
F
V
I
M
V
D
Q
T
S
Q
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
E
V
T
M
E
E
L
G
G
A
H
T
H
M
A
K
S
G
T
A
H
Y
A
A
S
G
E
Q
D
A
F
D
Y
V
R
E
L
L
S
Y
L
P
P
N
N
S
T
D
A
P
R
Y
Q
---
A
A
A
P
TGPIEENLT
D
E
------
D
-----
L
E
L
D
T
L
I
P
D
S
P
N
Q
P
Y
D
M
H
E
V
I
T
R
L
L
D
D
--
E
F
L
E
I
Q
A
G
Y
A
Q
N
I
V
V
G
F
G
R
I
D
G
R
P
V
G
I
V
A
N
Q
P
T
H
F
A
G
C
L
D
I
N
A
S
E
K
A
A
R
F
V
R
T
C
D
C
F
N
I
P
I
V
M
L
V
D
V
P
G
F
L
P
G
T
D
Q
E
Y
N
G
I
I
R
R
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
K
I
T
V
I
T
R
K
A
Y
G
G
A
Y
C
V
M
G
S
K
D
M
G
C
D
V
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
S
G
A
V
G
F
V
Y
R
Q
Q
--------
I
D
K
L
R
L
R
L
Q
Q
E
Y
E
D
T
L
V
N
P
Y
-
V
A
A
E
R
G
Y
V
G
A
V
I
P
P
S
H
T
R
G
Y
I
G
T
A
L
R
L
L
E
R
K
------
K
K
H
G
N
V
P
L
10
PsiBlast_PDB
81.81
43%
-93
- C2 -
1XNV
-
?
A:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
F
P
E
E
------------
A
D
LAVT
D
E
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
D
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
PP
K
K
H
G
N
I
P
L
51
HHSearch
81.76
40%
-90
* C2 *
1ON3
5
12S_PROFR
A:
[40-523]
-------------
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
H
S
F
D
E
V
G
A
FRKHRTTLFGMDK
A
V
V
---------------
P
A
D
-------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
F
V
N
---
P
NNDV--------
S
P
------
N
-----
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
-
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
D
D
P
--
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
N
T
P
Y
-
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
PA
K
K
H
G
N
F
P
C
23
PsiBlast_CBE
81.44
43%
-93
- C2 -
3IB9
3
?
B:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
FPE
E
------------
A
D
LAVTDE
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
L
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
ESLPP
K
K
H
G
N
I
P
L
6
PsiBlast_PDB
81.41
43%
-94
- C2 -
3IAV
6
?
A:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
F
P
E
E
------------
A
D
LAVT
D
E
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
22
PsiBlast_CBE
81.37
43%
-94
- C2 -
3IAV
4
?
B:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
FPE
E
------------
A
D
LAVTDE
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
ESLPP
K
K
H
G
N
I
P
L
47
HHSearch
81.10
41%
-90
- C2 -
1VRG
2
?
A:
[43-527]
-------------
R
A
G
K
L
T
A
W
E
R
L
E
L
L
L
D
P
G
T
F
V
E
I
D
K
---------------
F
V
E
H
R
NTYFGLDK
V
K
L
P
R
D
-------------
G
V
I
T
G
V
G
E
I
N
G
R
K
V
A
V
F
S
Q
D
F
T
V
M
G
G
S
L
G
E
M
H
A
K
K
I
V
K
L
L
D
L
A
L
K
M
G
I
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
A
L
A
G
Y
G
E
I
F
L
R
N
T
L
A
S
G
V
V
P
Q
I
T
V
I
A
G
P
C
A
G
G
A
V
Y
S
P
A
L
T
D
F
I
V
M
V
D
Q
T
A
R
M
F
I
T
G
P
N
V
I
K
A
V
T
G
E
E
I
S
Q
E
D
L
G
G
A
M
V
H
N
Q
K
S
G
N
A
H
F
L
A
D
N
D
E
K
A
M
S
L
V
R
T
L
L
S
Y
L
P
S
N
N
A
E
E
P
P
V
E
D
---
P
DTSL--------
E
T
------
P
-----
E
D
I
L
D
I
L
P
D
N
P
N
K
G
Y
D
V
R
D
V
I
K
R
V
V
D
H
G
-
E
F
F
E
V
Q
P
Y
F
A
K
N
I
V
I
G
F
A
R
I
Q
G
K
T
V
G
I
V
A
N
Q
P
S
V
L
A
G
V
L
D
I
D
S
S
D
K
A
A
R
F
I
R
F
L
D
A
F
N
I
P
I
L
T
F
V
D
T
P
G
Y
L
P
G
V
A
Q
E
H
G
G
I
I
R
H
G
A
K
L
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
I
L
R
K
A
Y
G
G
A
Y
I
A
M
G
S
K
H
L
G
A
D
M
V
L
A
W
P
S
A
E
I
A
V
M
G
P
E
G
A
A
N
I
I
F
K
R
E
I
E
A
S
S
N
P
--
E
E
T
R
R
K
L
I
E
E
Y
K
Q
Q
F
A
N
P
Y
-
I
A
A
S
R
G
Y
V
D
M
V
I
D
P
R
E
T
R
K
Y
I
M
R
A
L
E
V
C
E
T
K
V
E
Y
R
P
K
K
K
H
G
N
I
P
L
33
PsiBlast_CBE
81.10
40%
-93
- C2 -
1ON9
2
12S_PROFR
B:
[84-522]
-------------------------------------------------------------------------------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
-
F
V
---
N
------------
P
N
------
N
DVSPN
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
-
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
--
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
-
N
T
P
Y
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
TRPA
K
K
H
G
N
F
P
-
17
PsiBlast_PDB
80.90
40%
-96
- C2 -
1ON9
2
12S_PROFR
A:
[84-522]
-------------------------------------------------------------------------------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
-
F
V
---
N
------------
P
N
------
N
DVSPN
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
-
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
--
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
-
N
T
P
Y
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
PA
K
K
H
G
N
F
P
-
35
PsiBlast_CBE
80.75
40%
-95
- C2 -
1ON3
4
12S_PROFR
E:
[84-522]
-------------------------------------------------------------------------------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
-
F
V
---
N
------------
P
N
------
N
DVSPN
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
-
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
--
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
-
N
T
P
Y
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
QTRPA
K
K
H
G
N
F
P
-
30
PsiBlast_CBE
80.74
40%
-94
- C2 -
1ON9
3
12S_PROFR
F:
[84-522]
-------------------------------------------------------------------------------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
-
F
V
---
N
------------
P
N
------
N
DVSPN
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
-
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
--
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
-
N
T
P
Y
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
QTRPA
K
K
H
G
N
F
P
-
38
PsiBlast_CBE
80.45
40%
-94
- C2 -
1ON3
6
12S_PROFR
B:
[84-522]
-------------------------------------------------------------------------------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
-
F
V
---
N
------------
P
N
------
N
DVSPN
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
-
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
--
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
-
N
T
P
Y
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
-
31
PsiBlast_CBE
80.29
40%
-94
- C2 -
1ON9
2
12S_PROFR
E:
[84-522]
-------------------------------------------------------------------------------------
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
V
K
L
S
G
V
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
-
A
H
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
N
T
E
E
A
S
-
F
V
---
N
------------
P
N
------
N
DVSPN
T
E
L
R
D
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
-
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
--
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
-
N
T
P
Y
V
A
A
A
R
G
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
QTRPA
K
K
H
G
N
F
P
-
7
PsiBlast_PDB
80.26
43%
-96
- C2 -
3IB9
3
?
A:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
F
P
E
E
------------
A
D
LAVT
D
E
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
L
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
24
PsiBlast_CBE
80.09
43%
-92
- C2 -
1XNY
4
?
B:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
FPE
E
------------
A
D
LAVTDE
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
D
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
R
T
I
A
D
A
G
D
-
D
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
ESLPP
K
K
H
G
N
I
P
L
11
PsiBlast_PDB
80.05
43%
-93
- C2 -
1XNY
4
?
A:
[51-530]
----------------------
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
FA-------------
R
---------------
H
R
S
TNFGLDANRPYGD
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
-
Y
L
P
S
N
N
L
S
E
P
-
P
A
F
P
E
E
------------
A
D
LAVT
D
E
D
-----
A
E
L
D
T
I
V
P
D
S
A
N
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