@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2264c: (2016-05-09 )
MATGARPALGLSIGVTNLAAVAADHSITRKPVLTLYRQRPPEVGVPSENPRLDEPGLVITDFVDRVGDSVGIVAADGSVYRSEALVADALLALAYTATGGRALPGSVTVTYPAHWGPAAVAALDSALRRASEWSHGTSSTAQPLSLLPDAAAALYAIRADPGIPARGIVAVCDFGGSGTGITLVDAADEYRPVAATVRHQAFSGDLIDQSLLSYVMSELPGTGAFDPAGTSAIGSLTKLRIECRKAKERLSSSTVTTLTDALGGDIRLTRNELEDTIRDSLDSVGRALEQTLARSGIRTAELVAIVSVGGGANIPAVTTTLSGRFCVPVVRTPRPQLTAAFGGALWAARRPGDTSATVLTAVTSATATAPADAPASVLQPALAWSEADEDSHIGPAPGYTAARPSLSFDHDAHAEPEPKSPPIPWYRLPAVIITGTTVAVLLVGAAVAIGLSTGDQPTAPGTPQRPGVTTTAAPPPSPAPASDGPTTEPAPPVQAPATGGPAPPLQQPLPPPPTTTNTQPAVTTDVITPAPTTPASAPPATTQPPATTQPPATTSPSPPPIPPIPPIPEIPQLPPGIPQVPGIGQFSAISGS
Atome Classification :
(20 SA)
-----------------------------------.........10........20---...-.---.-------.-------..----------30........40........50........60.......-------------------------.70--------------.--------------------------.--------------------------.----------------------------..--...80........90........100...-.---....110.......120.......130.......140.......150.......160-..--.-----......170.......180......-----.-190.......200.......210.......220.......230.......240.......250.-----.-----.....260---------.-------......270..----.....280.......290.......300.......310.......320....-...--330----.........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......-520.......530.......540.......550.......560.......570.......580.......590-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MATGARPA
L
G
L
S
IGV
T
N
L
A
A
V
---AAD-H---S-------I-------TR----------
K
P
V
L
T
L
Y
RQRPPEVGVPSENPRLDEPG
L
V
I
T
D
F
V
D
RVGD-------------------------S
V
G
--------------
I
--------------------------
V
--------------------------A----------------------------AD--GSV
Y
R
S
E
A
L
V
A
D
A
L
L
A
L
A
YTATGG-RALP-G---
S
V
T
V
T
YPAHWG
P
A
A
V
A
A
L
D
S
A
L
R
R
A
S
EWSHGTSSTAQ
P
L
S
LLPD
A
A
A
A
L
Y
A
I
RAD---PG--I-----PAR
G
I
V
A
V
C
DFGGSGT
G
I
T
L
V
DAAD-----E-YR
P
V
A
A
T
V
R
HQAFS
G
D
L
I
D
Q
S
L
L
S
Y
V
M
S
ELPGTGAFDPA
G
T
S
A
I
G
S
L
T
K
L
R
I
E
C
R
K
A
K
E
RLSSS-----
T
-----
V
T
T
L
T
D
AL---------G-------G
D
I
R
L
T
R
N
E
L
E
----
D
T
I
R
D
S
L
D
S
V
G
R
A
L
E
Q
T
L
A
RSGIR
T
A
E
L
V
A
I
V
S
VGGGANI
P
A
V
T
TTLSG
R
F
C
-
V
P
V--V------RTPRP
Q
L
T
A
A
FGG
A
L
W
AARRPGDTS
A
T
V
L
T
A
VTSATATAPADA
P
A
S
V
L
Q
P
A
LAWSEADEDSHIGPAPGYTAARPSLSFDHDAHAEPEPKSPPIP
W
Y
R
L
P
A
V
I
I
TG
T
T
V
A
V
L
L
V
G
A
A
V
A
I
GLSTGDQPTAPGTPQRPGVTTTAAPPPSPAPASDGPTTEPAPPVQAPATGGPAPPLQQPLPPPPTTTNTQ-PA
V
T
TDVITPAPTTPASAPPATTQPPATTQPPATTSPSPPPIPPIPPIPEIPQLPPGIPQVPGIGQFSAISGS-
28
HHSearch
90.54
25%
-88
- C3 -
4RTF
2
?
D:
[35-388]
-----------------------------------------
R
A
V
G
I
D
L
G
T
T
N
S
V
V
S
---
V
L
E
G
G
DPV
V
VANSEGS
R
-------
T
T
----------
P
S
I
V
A
F
A
R
N
G
E
V
L
V
G
Q
P
A
K
N
Q
A
V
T
N
V
D
R
T
V
R
S
V
K
R
H
M
G
S
-------------------------
D
W
S
--------------
I
-----------------------------------------------------
E
----------------------------
I
D
--
G
K
K
Y
T
A
P
E
I
S
A
R
I
L
M
K
L
K
R
D
A
E
A
Y
L
G
E
D
I
-
T
---
D
A
V
I
T
T
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
Q
I
A
G
---
L
------
N
V
L
R
I
V
N
E
P
T
A
A
A
L
A
Y
G
L
D
---
K
----------
K
E
Q
R
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
E
I
G
------
G
-
V
V
E
V
R
A
T
S
G
D
N
H
L
G
G
D
D
W
D
Q
R
V
V
D
W
L
V
D
K
F
K
G
T
S
G
I
D
L
T
--
K
D
K
M
A
M
Q
R
L
R
E
A
A
E
K
A
K
I
E
L
S
S
S
-----
Q
-----
S
T
S
I
N
L
P
Y
---------
I
TVDNPLF
L
D
E
Q
L
T
R
A
E
F
Q
----
R
I
T
Q
D
L
L
D
R
T
R
K
P
F
Q
S
V
I
A
D
T
G
I
S
V
S
E
I
D
H
V
V
L
V
G
G
S
T
R
M
P
A
V
T
D
L
V
K
E
L
T
G
G
K
E
P
--
N
------
K
G
V
N
P
D
E
V
V
A
V
G
A
A
L
Q
A
G
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
90.37
21%
-75
- C3 -
4JNE
9
DNAK_ECOLI
A:
[1-382]
---------------------------------------
S
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
---
I
M
D
G
T
T
P
R
V
L
E
N
AEGD
R
-------
T
T
----------
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
-------------------------
R
F
Q
--------------
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
---
V
--------------------------
E
----------------------------
V
K
--
G
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
-
T
---
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
---
L
------
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
---
K
G
--------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
DG
E
K
T
-
F
E
V
-
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
--
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-----
Q
-----
Q
T
D
V
N
L
P
Y
ITADAT
G
P
K
H
-------
M
N
I
K
V
T
R
A
K
L
E
----
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
-
K
E
P
--
R
------
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
89.64
22%
-84
- C3 -
2V7Y
2
DNAK_GEOKA
A:
[1-351]
---------------------------------------
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
---
V
L
E
G
G
E
V
K
V
-------
I
P
N
PEGNR
T
T
----------
P
S
V
V
A
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
-------------------------
D
Y
K
--------------
V
-----------------------------------------------------
E
----------------------------
I
E
--
G
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
-
T
---
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
---
L
------
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
---
K
E
---------
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
D
-----
G
V
F
E
V
-
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
--
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-----
T
-----
Q
T
Q
I
S
L
P
F
ISANEN
G
P
L
H
-------
L
E
M
T
L
T
R
A
K
F
E
----
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
-
K
E
P
--
H
------
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
87.50
23%
-78
- C3 -
4GNI
1
?
A:
[13-401]
----------------------------------------
R
V
V
I
G
I
T
F
G
N
S
N
S
S
I
A
---
H
T
V
D
D
K
A
E
V
I
A
N
EDGD
R
-------
Q
I
----------
P
T
I
L
S
Y
V
D
G
-
D
E
Y
Y
G
Q
Q
A
K
N
F
L
V
R
N
P
K
N
T
V
A
Y
F
R
D
I
L
G
Q
-------------------------
D
F
K
--------------
S
--------------------------
V
--------------------------
D
PTHNHA
S
A
H
P
Q
E
A
GD
N
V
V
F
T
I
KDKAEED
A
E
--
P
S
T
L
T
V
S
E
I
A
T
R
Y
L
R
R
L
V
G
A
A
S
E
Y
L
G
K
K
V
-
T
---
S
A
V
I
T
I
P
T
N
F
T
E
K
Q
K
A
A
L
I
A
A
A
A
A
A
D
---
L
------
E
V
L
Q
L
I
S
E
P
A
A
A
V
L
A
Y
D
A
---------------
S
D
K
I
I
V
V
A
D
L
G
G
S
R
S
D
V
T
V
L
A
S
R
S
G----
M
-
Y
T
I
-
L
A
T
V
H
D
Y
E
Y
H
G
I
A
L
D
K
V
L
I
D
H
F
S
K
E
F
L
K
K
N
P
G
A
K
D
P
R
E
N
P
R
S
L
A
K
L
R
L
E
A
E
S
T
K
R
A
L
S
R
S
-----
T
-----
N
A
S
F
S
V
E
S
---------
L
IDG
L
D
--
F
A
S
T
I
N
R
L
R
Y
E
----
T
I
A
R
T
V
F
E
G
F
N
R
L
V
E
S
A
V
K
K
A
G
L
D
P
L
D
V
D
E
V
I
M
S
G
G
T
S
N
T
P
R
I
A
A
N
F
R
Y
I
F
P
-
E
S
T
RI
L
APSTDP
S
A
L
N
P
S
E
L
Q
A
R
G
A
A
L
Q
A
S
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
85.50
22%
-83
- C3 -
3QFU
3
GRP78_YEAST
A:
[16-392]
--------------------------------------
N
Y
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
---
V
M
K
N
G
K
T
E
I
L
A
N
EQGN
R
-------
I
T
----------
P
S
Y
V
A
F
T
D
D
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
-------------------------
K
Y
N
D
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
--------------
V
--------------------------
K
----------------------------
G
E
--
K
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
-
T
---
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
---
L
------
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
S
--------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
E
N
-----
G
-
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
--
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
-----
M
-----
S
T
R
I
E
I
D
S
---------
F
VDG
I
D
--
L
S
E
T
L
T
R
A
K
F
E
----
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
K
K
A
--
S
------
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
84.53
21%
-79
- C3 -
3I33
3
HSP72_HUMAN
A:
[23-401]
----------------------------------------
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
---
V
F
Q
H
G
K
V
E
I
I
A
N
DQGN
R
-------
T
T
----------
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
-------------------------
K
F
E
--------------
D
A
T
V
Q
S
D
M
K
H
WP
F
R
V
------------
V
S
E
GG
K
P
K
V
Q
V
E
Y
--------------
K
----------------------------
G
E
--
T
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
-
H
---
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
---
L
------
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
GC
A
-----
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G----
I
-
F
E
V
-
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
--
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
-----
Q
A
S
I
E
I
D
S
---------
L
YEG
V
D
--
F
Y
T
S
I
T
R
A
R
F
E
----
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
83.56
21%
-85
* C3 *
4FL9
3
HSP7C_BOVIN
A:
[4-392]
----------------------------------------
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
---
V
F
Q
H
G
K
V
E
I
-------
I
A
N
DQGNR
T
T
----------
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
-------------------------
R
F
D
--------------
D
--------------------------
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
K
----------------------------
G
E
--
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
-
T
---
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
---
L
------
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
-----
G
I
F
E
V
-
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
--
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
-----
Q
A
S
I
E
I
D
S
---------
L
YEG
I
D
--
F
Y
T
S
I
T
R
A
R
F
E
----
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.85
21%
-83
- C3 -
4J8F
14
F10A1_RAT (first)
A:
[7-385]
------------------------------------
F
M
A
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
---
V
F
Q
H
G
KVE
I
IANDQGN
R
-------
T
T
----------
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
-------------------------
K
F
G
--------------
D
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
--------------------------
K
----------------------------
G
E
--
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
-
T
---
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
---
L
------
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
R
T
--
G
-----
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
-----
G
I
F
E
V
-
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
--
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
-----
Q
A
S
L
E
I
D
S
---------
L
FEG
I
D
--
F
Y
T
S
I
T
R
A
R
F
E
----
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
81.57
21%
-77
- C3 -
5E84
7
GRP78_HUMAN
A:
[2-383]
-------------------------------------
E
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
---
V
F
K
N
G
RVE
I
IANDQGN
R
-------
I
T
----------
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
-------------------------
T
W
N
--------------
D
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
------------
V
E
K
KT
K
P
Y
I
Q
V
----------------
D
IGG-------------------------
G
Q
--
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
-
T
---
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
---
L
------
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
R
--------
E
G
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
D
N
-----
G
V
F
E
V
-
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
--
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-----
H
-----
Q
A
R
I
E
I
E
S
---------
F
YEG
E
D
--
F
S
E
T
L
T
R
A
K
F
E
----
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
K
E
P
--
S
------
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
81.16
14%
-52
- C3 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
-----------------------------------------
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
---
V
A
R
-
N
---
R
-------
G
-------
I
D
I
V
V
N
EVSNRS
T
P
S
V
V
G
F
G
P
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
DYHHPD
F
E
Q
E
S
K
H
FT
S
K
L
V
E
L
DDK
K
T
G
A
--------------
E
--------------------------
V
--------------------------
R
----------------------------
F
A
--
G
E
K
H
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
-
Q
D
T
K
-
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
-------
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
T
DLP
E
G
--
E
-----
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
-----
G
-
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
Y
K
I
D
I
R
E
N
--
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
T
N
A
P
F
S
-----
V
E
S
V
M
N
D
V
---------
D
-------
V
S
S
Q
L
S
R
E
E
L
E
----
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
-
K
P
L
--
S
------
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
R
P
F
K
F
E
D
I
H
P
Y
-
S
V
S
Y
S
W
D
K
Q
V
E
D
E
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
-
D
I
T
Q
L
P
P
N
T
P
E
Q
I
A
N
W
E
I
T
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
Y
T
I
E
D
K
T
----
V
K
K
D
D
L
T
I
V
A
H
T
F
G
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
A
S
--
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
D
E
G
F
D
S
I
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
21
HHSearch
80.79
19%
-83
- C3 -
3D2F
4
?
A:
[2-390]
----------------------------------------
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
---
V
A
R
N
R
G
I
D
I
-------
V
V
N
EVSNR
S
T
----------
P
S
V
V
G
F
G
P
-
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
-------------------------
D
Y
H
--------------
H
PD
F
E
Q
E
S
K
H
FT
S
K
L
------------
V
E
L
DDK
K
T
G
A
E
V
R
F
-------------
A
----------------------------
G
E
--
K
H
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
-
T
---
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
---
L
------
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
---
K
T
--
D
LPEGE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G----
Q
-
L
K
V
-
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
Y
K
I
D
I
R
--
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
-----
T
-----
N
A
P
F
S
V
E
S
---------
V
MND
V
D
--
V
S
S
Q
L
S
R
E
E
L
E
----
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
-
K
P
L
--
S
------
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
75.85
18%
-88
- C3 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
KIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTP
S
I
I
A
Y
T
Q
D
---------
G
E
T
L
VGQ
P
A
K
-
R
---
Q
-------
A
-------
V
T
----------
N
P
Q
N
T
L
F
A
I
K
R
L
-
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
A
A
D
N
-------------------------
G
D
A
--------------
W
--------------------------
V
--------------------------
E
----------------------------
V
-KG-
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
-
L
G
E
P
V
T
---
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
-
A
G
L
--------
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
---
K
---------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
E
KTF--
E
-
V
L
A
---
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
--
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
------------------------------------------------------------------------------------
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
-
M
N
I
--
K
------
V
T
--
R
A
K
L
E
S
L
V
E
D
L
V
N
---------
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
--
L
S
V
S
D
I
D
--------------------------------------------------
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
--------------------------
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
-------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.02
24%
-91
- C3 -
1BA0
3
HSP7C_BOVIN
A:
[136-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.93
24%
-92
- C3 -
2QWL
3
HSP7C_BOVIN
A:
[136-384]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.88
24%
-91
- C3 -
2QWM
4
HSP7C_BOVIN
A:
[136-384]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.76
24%
-90
- C3 -
2QWO
5
HSP7C_BOVIN
A:
[136-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
E
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.64
24%
-95
- C3 -
1ATS
2
HSP7C_BOVIN
A:
[136-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.63
24%
-87
- C3 -
2QWN
4
HSP7C_BOVIN
A:
[136-385]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.50
24%
-90
- C3 -
1NGC
2
HSP7C_BOVIN
A:
[136-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.40
24%
-91
- C3 -
2QWP
5
HSP7C_BOVIN
A:
[136-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
T
V
T
-
N
---
A
V
-
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
---------
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
---
K
K
--
V
-----
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
-----
G
-
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
--
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-----
T
Q
A
S
I
E
I
D
S
L
Y
E
G
I
---------
D
-------
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
----
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--
N
------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
E
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------