@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2266: (2016-05-09 )
MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS
Atome Classification :
(49 SA)
.........10........20........30........40....---....50.......--.60-........---70........80........90...--..----...---100..-....-.-.110-.......120.......130.......140.......150.......-160.......170.......180.......190...-....200....-.-..210..----.....220.......230.......240..-.....250.......260.......270.......280.......290.......300-.......310...-..--..-320.......330.......340.......350.......360.......370-.......380.......390.......400-.---.....-.410..---.---......420......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGLN
T
A
I
A
TRVNGTPPPEV
P
I
A
D
I
E
LGS
L
D
F
W
ALDDDVRD
G
A
F
A
T
---
L
RREAPISFWPTI--ELP-
G
F
VAGNG
H
---
W
A
L
T
K
YD
D
V
F
YASRH
P
D
I
F
S
SYP
N
I
--
T
I----NDQ---T
P
-
E
L
-
A
E
Y
F-G-
S
M
I
V
-LDD
P
R
H
Q
R
L
R
S
I
V
S
RAF
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
IANNP
D
R
-
Q
A
D
L
V
S
E
L
AGPL
P
L
Q
I
I
C
D
M
MGIPK
A
D
H
Q
R
I
F
H
W
T
N
-
V
I
L
GFGD
P
D
LA-T-
D
F
D
E
F
M
Q
----
V
S
ADI
G
A
Y
A
T
A
L
AEDRRVN
H
H
D
D
L
T
S
S
L
V
E
-AEVDGERL
S
S
R
E
I
A
S
F
F
I
L
L
V
V
AGNET
T
R
N
A
I
T
H
G
V
L
A
L
S
RY
P
E
Q
R
D
R
W
WSDFDGL
A
P
-
T
A
V
E
E
I
V
R
WA
S
P
V
-
V
Y
--
M
R
-
R
T
LTQD
I
E
LRGTKMAAG
D
K
V
S
L
W
Y
CSANRDESKFADP
W
T
F
DLARNPNPHLGFG-GGGA
H
F
C
LGA
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
QMPD-V---VATE
E
-
P
A
--
R
L
---
L
---
S
Q
F
I
H
GIKTLPVTWS
1
PsiBlast_PDB
100.00
100%
-104
- C7 -
2WM4
3
CP124_MYCTU
A:
[10-435]
--
L
N
T
A
I
A
T
R
V
N
G
T
P
P
P
E
V
P
I
A
D
I
E
L
G
S
L
D
F
W
A
L
D
D
D
V
R
D
G
A
F
A
T
---
L
R
R
E
A
P
I
S
F
W
P
T
I
--
E
L
P
-
G
F
V
A
G
N
G
H
---
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
I
F
S
S
Y
P
N
I
--
T
I
----
N
D
Q
---
T
P
-
E
L
-
A
E
Y
F
-
G
-
S
M
I
V
-
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
N
N
P
D
R
-
Q
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
-
V
I
L
G
F
G
D
P
D
L
A
-
T
-
D
F
D
E
F
M
Q
----
V
S
A
D
I
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
E
-
A
E
V
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
-
T
A
V
E
E
I
V
R
W
A
S
P
V
-
V
Y
--
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
N
P
N
P
H
L
G
F
G
-
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
-
V
---
V
A
T
E
E
-
P
A
--
R
L
---
L
---
S
Q
F
I
H
G
I
K
T
L
P
V
T
W
S
2
PsiBlast_PDB
97.28
100%
-99
- C7 -
2WM5
1
CP124_MYCTU
A:
[8-435]
M
G
L
N
T
A
I
A
T
R
V
N
G
T
P
P
P
E
V
P
I
A
D
I
E
L
G
S
L
D
F
W
A
L
D
D
D
V
R
D
G
A
F
A
T
---
L
R
R
E
A
P
I
S
F
W
P
T
I
--
E
L
----
V
A
G
N
G
H
---
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
I
F
S
S
Y
P
N
I
--
T
I
----
N
D
Q
---
T
P
-
E
L
-
A
E
Y
F
-
G
-
S
M
I
V
-
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
N
N
P
D
R
-
Q
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
-
V
I
L
G
F
G
D
P
D
L
A
-
T
-
D
F
D
E
F
M
Q
----
V
S
A
D
I
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
E
-
A
E
V
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
-
T
A
V
E
E
I
V
R
W
A
S
P
V
-
V
Y
--
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
N
P
N
P
H
L
G
F
G
-
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
-
V
---
V
A
T
E
E
-
P
A
--
R
L
---
L
---
S
Q
F
I
H
G
I
K
T
L
P
V
T
W
S
120
HHSearch
97.00
100%
-99
- C7 -
2WM5
1
CP124_MYCTU
A:
[8-435]
M
G
L
N
T
A
I
A
T
R
V
N
G
T
P
P
P
E
V
P
I
A
D
I
E
L
G
S
L
D
F
W
A
L
D
D
D
V
R
D
G
A
F
A
T
---
L
R
R
E
A
P
I
S
F
W
P
T
I
--
E
L
----
V
A
G
N
G
H
---
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
I
F
S
S
Y
P
N
I
--
T
I
----
N
D
Q
---
T
P
-
E
L
-
A
E
Y
F
-
G
-
S
M
I
V
-
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
N
N
P
D
R
-
Q
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
-
V
I
L
G
F
G
D
P
D
L
A
-
T
-
D
F
D
E
F
M
Q
----
V
S
A
D
I
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
E
-
A
E
V
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
-
T
A
V
E
E
I
V
R
W
A
S
P
V
-
V
Y
--
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
N
P
N
P
H
L
G
F
G
G
G
-
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
-
V
---
V
A
T
E
E
-
P
A
--
R
L
---
L
---
S
Q
F
I
H
G
I
K
T
L
P
V
T
W
S
6
PsiBlast_PDB
79.15
41%
-102
- C7 -
3IW2
2
CP125_MYCTU
A:
[43-426]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
-------
I
V
T
Q
L
I
Q
-
A
D
--
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
8
PsiBlast_PDB
78.75
41%
-97
- C7 -
2X5W
4
CP125_MYCTU
A:
[50-433]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
A
K
N
P
A
D
D
I
V
T
Q
L
I
Q
-
A
D
I
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
5
PsiBlast_PDB
78.46
41%
-101
- C7 -
3IW1
2
CP125_MYCTU
A:
[43-426]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
-------
I
V
T
Q
L
I
Q
-
A
D
--
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
3
PsiBlast_PDB
78.07
41%
-101
- C7 -
3IVY
1
CP125_MYCTU
A:
[43-426]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
-------
I
V
T
Q
L
I
Q
-
A
D
--
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
9
PsiBlast_PDB
77.89
41%
-100
- C7 -
2XN8
2
CP125_MYCTU
A:
[33-416]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
A
K
--
A
D
D
I
V
T
Q
L
I
Q
-
A
D
--
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
11
PsiBlast_PDB
77.80
40%
-96
- C7 -
4APY
12
?
A:
[27-409]
------------------------------------------
L
A
E
---
L
R
K
S
E
P
I
H
W
V
D
V
P
--
G
G
T
-
G
G
F
G
D
K
G
Y
---
W
L
V
T
K
H
A
D
V
K
E
V
S
R
R
S
D
V
F
G
S
S
P
D
G
--
A
I
PVWP
Q
D
M
---
T
R
-
E
A
-
V
D
L
Q
-
R
-
A
V
L
L
N
M
D
A
P
Q
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
I
G
R
L
E
D
E
L
R
S
R
A
Q
K
I
A
Q
T
A
A
A
Q
G
----
A
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
E
L
L
G
V
P
Q
D
D
R
D
K
L
F
R
W
S
N
-
E
M
T
A
G
E
D
P
E
Y
A
---
D
V
D
P
A
M
S
-----
S
F
E
L
I
S
Y
A
M
K
M
A
E
E
R
A
V
N
P
T
E
D
I
V
T
K
L
I
E
-
A
D
I
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
H
G
M
I
A
F
A
Q
N
P
D
Q
----
W
E
L
Y
K
K
E
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
S
A
--
F
Q
-
R
T
A
L
E
D
V
E
L
G
G
V
Q
I
K
K
G
Q
R
V
V
M
S
Y
R
S
A
N
F
D
E
E
V
F
E
D
P
H
T
F
N
I
L
R
S
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
I
A
D
N
M
P
D
-
L
---
K
P
I
G
A
-
P
E
--
R
L
---
K
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
7
PsiBlast_PDB
77.72
41%
-99
- C7 -
2XC3
2
CP125_MYCTU
A:
[34-417]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
A
-----
D
I
V
T
Q
L
I
Q
-
A
D
I
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
10
PsiBlast_PDB
77.32
41%
-96
- C7 -
2X5L
1
CP125_MYCTU
A:
[41-424]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
A
K
N
P
A
D
D
I
V
T
Q
L
I
Q
-
A
D
I
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
122
HHSearch
77.08
42%
-96
- C7 -
3IVY
1
CP125_MYCTU
A:
[38-426]
-------------------------------------
L
P
V
A
E
F
A
E
---
L
R
S
A
A
P
I
W
W
N
G
Q
D
PG
K
G
G
-
G
F
-
H
D
G
G
F
---
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
----
P
R
F
KND
I
A
R
E
D
-
I
E
V
Q
R
F
-
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
---
G
-
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
-
H
---
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
-------
I
V
T
Q
L
I
Q
-
A
D
--
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
-
L
Y
K
K
V
R
P
--
E
-
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
G
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
12
PsiBlast_PDB
76.57
40%
-93
- C7 -
5DQN
4
?
A:
[27-409]
------------------------------------------
L
A
E
---
L
R
K
S
E
P
I
H
W
V
D
V
P
--
G
G
T
-
G
G
F
G
D
K
G
Y
---
W
L
V
T
K
H
A
D
V
K
E
V
S
R
R
S
D
V
F
G
S
S
P
D
G
--
A
I
PVYP
Q
D
M
---
T
R
-
E
A
-
V
D
L
Q
-
R
-
A
V
L
L
N
M
D
A
P
Q
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
I
G
R
L
E
D
E
L
R
S
R
A
Q
K
I
A
Q
T
A
A
A
Q
G
----
A
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
E
L
L
G
V
P
Q
D
D
R
D
K
L
F
R
W
S
N
-
E
M
T
A
G
E
D
P
E
Y
A
---
D
V
D
P
A
M
S
-----
S
F
E
L
I
S
Y
A
M
K
M
A
E
E
R
A
V
N
P
T
E
D
I
V
T
K
L
I
E
-
A
D
I
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
H
G
M
I
A
F
A
Q
N
P
D
Q
----
W
E
L
Y
K
K
E
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
S
A
--
F
Q
-
R
T
A
L
E
D
V
E
L
G
G
V
Q
I
K
K
G
Q
R
V
V
M
S
Y
R
S
A
N
F
D
E
E
V
F
E
D
P
H
T
F
N
I
L
R
S
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
I
A
D
N
M
P
D
-
L
---
K
P
I
G
A
-
P
E
--
R
L
---
K
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
4
PsiBlast_PDB
76.56
41%
-97
- C7 -
3IW0
2
CP125_MYCTU
A:
[43-426]
------------------------------------------
F
A
E
---
L
R
S
A
A
P
I
--
W
W
N
G
--
Q
D
P
-
G
K
G
G
G
F
H
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
Y
E
N
G
--
V
I
PRFK
N
D
I
---
A
R
-
E
D
-
I
E
V
Q
-
R
F
V
M
L
N
-
M
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
A
G
----
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
-
E
M
T
G
N
E
D
P
E
Y
A
----
H
I
D
P
K
A
----
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
A
K
N
P
A
D
D
I
V
T
Q
L
I
Q
-
A
D
I
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
----
W
E
L
Y
K
K
V
R
P
E
T
A
A
D
E
I
V
R
W
A
T
P
V
-
T
A
--
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
N
P
H
V
G
F
G
-
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
-
L
---
K
P
I
S
A
-
P
E
--
R
L
---
R
---
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
13
PsiBlast_PDB
74.50
35%
-91
- C7 -
2XKR
2
CP142_MYCTU
A:
[4-392]
--------------------------------
A
P
D
V
D
L
A
D
G
N
F
Y
A
---
S
R
E
A
R
A
A
Y
R
W
M
R
A
--
N
Q
P
-
V
F
R
D
R
N
G
L
---
A
A
A
S
T
Y
Q
A
V
I
D
A
E
R
Q
P
E
L
F
S
N
A
G
G
I
--
R
P
----
D
-----
Q
P
-
A
L
-
P
------
M
M
I
D
-
M
D
D
P
A
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
K
D
K
E
A
S
I
A
A
L
C
D
T
L
I
D
A
V
C
E
R
G
----
E
C
D
F
V
R
D
L
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
R
P
E
Q
R
D
M
F
L
R
W
S
D
-
D
L
V
T
F
L
S
S
H
V
S
-
Q
E
D
F
Q
I
T
M
D
----
A
F
A
A
Y
N
D
F
T
R
A
T
I
A
A
R
R
A
D
P
T
D
D
L
V
S
V
L
V
S
-
S
E
V
D
G
E
R
L
S
D
D
E
L
V
M
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
N
R
D
Q
W
D
L
L
Q
R
D
-
P
S
L
L
P
-
G
A
I
E
E
M
L
R
W
T
A
P
V
-
K
N
--
M
C
-
R
V
L
T
A
D
T
E
F
H
G
T
A
L
C
A
G
E
K
M
M
L
L
F
E
S
A
N
F
D
E
A
V
F
C
E
P
E
K
F
D
V
Q
R
N
P
N
S
H
L
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
R
L
P
D
-
L
---
R
L
V
A
D
-
D
S
--
V
L
PLR
P
---
A
N
F
V
S
G
L
E
S
M
P
V
V
F
T
28
PsiBlast_CBE
73.87
36%
-95
- C7 -
2YOO
2
?
C:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
14
PsiBlast_PDB
73.62
36%
-96
- C7 -
2YOO
2
?
A:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
25
PsiBlast_CBE
73.46
36%
-96
- C7 -
3ZBY
5
?
C:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
21
PsiBlast_CBE
73.46
36%
-97
- C7 -
4TRI
3
?
B:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
29
PsiBlast_CBE
73.09
36%
-96
- C7 -
2YOO
2
?
B:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
16
PsiBlast_PDB
73.03
36%
-95
- C7 -
4TRI
3
?
A:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
79
PsiBlast_CBE
72.52
34%
-93
- C7 -
3ZK5
2
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
17
PsiBlast_PDB
72.44
36%
-96
- C7 -
4UAX
1
?
A:
[29-394]
---------------------------------------------------------
W
M
R
A
--
N
E
P
-
V
F
R
D
R
N
G
L
---
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
S
T
G
G
I
--
R
-----
P
D
Q
----
P
-
G
M
-
P
------
Y
M
I
D
-
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
---
R
V
M
D
K
V
-
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
S
H
V
D
E
-
A
-
A
I
Q
K
L
M
D
----
T
F
A
A
Y
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
N
-
S
E
V
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
--
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
-
L
R--
L
A
D
D
A
-
P
V
--
P
L
---
R
P--
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
80
PsiBlast_CBE
72.27
34%
-91
- C7 -
3ZK5
2
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
95
PsiBlast_CBE
72.25
34%
-91
- C7 -
2C6H
6
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
77
PsiBlast_CBE
72.23
34%
-93
- C7 -
3ZPI
6
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
58
PsiBlast_CBE
72.07
34%
-89
- C7 -
4UMZ
2
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
76
PsiBlast_CBE
72.06
34%
-91
- C7 -
4B7S
14
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
55
PsiBlast_CBE
72.03
34%
-93
- C7 -
2WHW
4
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
94
PsiBlast_CBE
71.85
34%
-93
- C7 -
2C6H
3
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
YAR
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
WYP
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
82
PsiBlast_CBE
71.82
34%
-91
- C7 -
2VZM
2
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
99
PsiBlast_CBE
71.68
34%
-92
- C7 -
3A4G
2
CPVDH_PSEAH
A:
[25-397]
-----------------------------------------
A
Y
A
A
---
L
R
A
E
D
P
V
R
---
K
L
--
A
L
P
D
G
P
V
--------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
W
R
H
T
--
L
P
----
E
D
Q
---
R
A
-
D
M
P
A
T
P
T
-
P
-
M
M
I
L
-
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
----
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
---
D
D
S
P
A
-
D
-
D
K
N
A
A
M
-------
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
-
K
L
L
A
E
D
P
S
L
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
-
S
Q
--
A
P
I
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
-
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
-
L
ALA
V
G
L
D
E
-
L
V
--
Y
R
---
E
---
S
T
L
V
R
G
L
S
R
M
P
V
T
--
98
PsiBlast_CBE
71.67
34%
-88
- C7 -
3A4H
2
CPVDH_PSEAH
A:
[25-397]
-----------------------------------------
A
Y
A
A
---
L
R
A
E
D
P
V
R
---
K
L
--
A
L
P
D
G
P
V
--------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
W
R
H
T
--
L
P
----
E
D
Q
---
R
A
-
D
M
P
A
T
P
T
-
P
-
M
M
I
L
-
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
----
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
---
D
D
S
P
A
-
D
-
D
K
N
A
A
M
-------
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
-
K
L
L
A
E
D
P
S
L
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
-
S
Q
--
A
P
I
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
-
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
-
L
ALA
V
G
L
D
E
-
L
V
--
Y
R
---
E
---
S
T
L
V
R
G
L
S
R
M
P
V
T
--
78
PsiBlast_CBE
71.51
34%
-91
- C7 -
3ZPI
13
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
97
PsiBlast_CBE
71.50
34%
-90
- C7 -
2BVJ
3
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
75
PsiBlast_CBE
71.37
34%
-92
- C7 -
4B7S
6
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
93
PsiBlast_CBE
71.18
34%
-90
- C7 -
2C7X
2
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
88
PsiBlast_CBE
71.13
34%
-91
- C7 -
4B7D
3
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
57
PsiBlast_CBE
71.09
34%
-92
- C7 -
4UMZ
2
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
133
HHSearch
71.06
35%
-95
- C7 -
2XKR
2
CP142_MYCTU
A:
[19-392]
-------------------------------------
E
A
R
A
A
Y
R
W
---
M
R
A
N
Q
P
V
F
R
D
R
N
G
-------------
L
---
A
A
A
S
T
Y
Q
A
V
I
D
A
E
R
Q
P
E
L
F
S
N
A
G
G
I
---
R
----
P
-----------
D
Q
P
A
L
P
-
M
M
I
D
-
M
D
D
P
A
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
K
D
K
E
A
S
I
A
A
L
C
D
T
L
I
D
A
V
C
E
R
---
G
-
E
C
D
F
V
R
D
L
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
R
P
E
Q
R
D
M
F
L
R
W
S
D
-
D
L
V
T
F
L
S
S
H
V
S
Q
E
-
D
F
Q
I
T
M
D
----
A
F
A
A
Y
N
D
F
T
R
A
T
I
A
A
R
R
A
D
P
T
D
D
L
V
S
V
L
V
S
-
S
E
V
D
G
E
R
L
S
D
D
E
L
V
M
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
N
R
D
Q
W
D
L
L
Q
R
D
P
-
S
L
L
P
-
G
A
I
E
E
M
L
R
W
T
A
P
V
-
K
N
--
M
C
-
R
V
L
T
A
D
T
E
F
H
G
T
A
L
C
A
G
E
K
M
M
L
L
F
E
S
A
N
F
D
E
A
V
F
C
E
P
E
K
F
D
V
Q
R
N
P
N
S
H
L
A
F
G
-
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
R
L
P
D
-
L
---
R
L
V
A
D
D
S
V
LP
L
R
---
P
---
A
N
F
V
S
G
L
E
S
M
P
V
V
F
T
54
PsiBlast_CBE
71.01
34%
-92
- C7 -
2WI9
2
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
WYP
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
83
PsiBlast_CBE
71.00
34%
-88
- C7 -
2VZ7
2
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
81
PsiBlast_CBE
70.99
34%
-93
- C7 -
2VZM
2
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
56
PsiBlast_CBE
70.67
34%
-92
- C7 -
2WHW
2
PIKC_STRVZ
A:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
19
PsiBlast_PDB
70.63
32%
-95
- C7 -
4RM4
1
YJIB_BACSU
A:
[30-394]
------------------------------------------
Y
E
S
---
M
R
K
D
A
P
V
S
F
------------
D
E
E
N
Q
V
---
W
S
V
F
L
Y
D
D
V
K
K
V
V
G
D
K
E
L
F
S
S
------
C
M
----------------
G
----
N
-
S
I
I
N
-
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
F
Q
G
R
S
----
E
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
A
H
M
E
Q
F
K
A
W
S
D
-
L
L
V
S
T
P
K
D
K
S
E
-
E
-
A
E
K
A
F
L
E
E
R
D
K
C
E
E
E
L
A
A
F
F
A
G
I
I
E
E
K
R
N
K
P
E
Q
D
I
I
S
I
L
V
E
-----
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
-
L
M
P
-
Q
A
V
E
E
A
L
R
F
R
A
P
A
-
P
V
--
L
R
-
R
I
A
K
R
D
T
E
I
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
H
P
N
P
H
I
A
F
--
G
H
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
-
M
---
E
C
V
-
S
-
I
T
--
P
I
---
E
---
N
S
V
I
Y
G
L
K
S
F
R
V
---
96
PsiBlast_CBE
70.12
34%
-93
- C7 -
2BVJ
3
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
------------
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
53
PsiBlast_CBE
70.08
34%
-92
- C7 -
2WI9
5
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
N
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
WYP
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
91
PsiBlast_CBE
69.62
34%
-89
- C7 -
2CA0
2
PIKC_STRVZ
B:
[35-425]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
YAR
L
R
A
E
G
P
A
H
R
V
R
T
P
--
E
-------
G
D
E
V
---
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
--
T
T
----
P
L
T
---
E
A
-
E
--
A
A
L
N
-
H
-
N
M
L
E
-
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
-
P
D
G
-
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
F
P
D
D
P
A
Q
A
--------
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
S
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
--
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
-
L
---
A
L
D
V
S
-
P
G
--
E
L
---
V
WYP
N
P
M
I
R
G
L
K
A
L
P
I
R
W
-
137
HHSearch
67.54
32%
-81
- C7 -
3WVS
8
?
A:
[24-401]
-------------------------------------
A
L
S
E
S
Y
T
R
---
A
R
D
T
D
G
L
I
R
V
K
L
P
---------
Y
G
E
P
A
---
W
L
A
T
R
Y
E
D
A
R
L
V
L
G
D
A
-
R
F
S
R
A
L
S
E
EH
D
P
----
P
R
-----
A
-
R
K
-
F
N
A
Q
A
K
-
S
M
F
N
-
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
K
-
G
-
E
-
P
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
-
A
I
L
S
T
S
T
L
N
-----
P
-
E
E
G
R
V
----
K
R
M
E
L
V
G
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
E
-
A
R
D
V
Q
D
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
-
E
L
I
P
-
S
A
V
E
E
L
F
R
F
V
P
L
G
-
S
G
SA
A
P
-
R
Y
A
R
E
D
I
E
V
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
D
P
E
E
I
K
L
D
R
P
S
N
H
H
I
G
F
G
-
H
-
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
-
P
T
L
---
K
V
A
G
D
-
I
A
--
W
K
---
S
---
E
M
M
V
R
G
P
R
S
M
P
V
G
W
-