@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2268c: (2016-05-09 )
MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDFDPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVTFSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPADVVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGFRRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMISTLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPAGSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100---.........110.......120---.......--130--........140.......-------150.......--160--..-----.....--.-.170----........180.......190.......200.......210.--......220.......230.......240.......250..-----.....-260.......270.......280....---.---..290.......300-------...--...-.310.......320.......330.......340.......350.......360.......370-..-.....380-.......390.......400.......410.......420.......430.......440.......450..-------....-.460----...---.---...-.470.......480.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTATQSPPEPAPD
R
V
R
LAGCPLAGTPDV
G
L
TAQDATTALGVPTRRRASSGGIP
V
A
T
S
MWR
D
A
Q
T
V
R
TY
G
P
A
V
A
K
A
L
A
L
R
VAG
K
A
R
S
R
L
T
G
R
H
C
R
K
F
M
Q
LT-----DFDPFDPAIAADP
Y
P
H
Y
R
E
LLA---GE
R
V
QYN--PK---R
D
V
Y
I
L
S
R
Y
A
D
V
R
E
A
ARN-------HDTLSSARG
V
--
T
----FS-----RGWLP--F-LPT-----SDP
P
A
H
T
R
M
R
K
Q
LAP
G
M
A
R
G
A
L
E
T
W
R
P
M
V
D
Q
L
A
R
E
L
V
G
G
L
LT--Q
T
P
A
D
V
V
S
T
V
AAPM
P
M
R
A
I
T
S
V
LGVDGP
D
E
A
A
F
C
RLSNQ
A
V
-----
R
I
T
D
V
-
A
L
S
A
S
G
L
I
S
L
V
Q
G
F
A
G
F
R
R
L
R
A
L
F
T
HR---R---DN
G
L
L
R
E
C
T
V
L
G
K
L
A
-------
T
H
A
--EQG-RLSD
D
E
L
F
F
F
A
V
L
L
L
VAG
Y
E
S
T
A
H
M
I
S
T
L
F
L
T
LADYP
D
Q
L
T
LLAQQPDL
I
P
S
A
I
E
E
H
L
R
F
I
S
P
I
-
Q
N
-
I
C
R
T
TRVD-YSVG
Q
A
VIPAG
S
L
V
L
L
A
WGAANRDPRQYEDPDVFRADRNPVGHLAFGS
G
I
HLCPG
T
Q
L
A
R
ME
G
Q
A
I
L
R
E
I
V
A-------NI
D
R
-
I
E
V
-----VEP---P---TWT-TNANLR
G
L
T
R
L
R
V
A
VTPRVAP
2
PsiBlast_PDB
97.98
34%
-114
- C5 -
3A4G
2
CPVDH_PSEAH
A:
[12-403]
-----------------------------------------------------------------------------------------------------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
---
E
D
P
V
R
K
L
AL
P
D
---
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
PRLSKDW
R
H
T
L
P
E
D
Q
R
A
--
D
----
M
P
-----
A
T
P
T
P
--
M
-
M
I
L
-----
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
--
S
V
-----
L
V
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
-----
L
S
D
L
L
E
R
K
---
R
T
E
P
D
D
A
L
L
S
S
L
-----
L
A
-------
V
S
D
--
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
-
P
I
R
F
T
A
E
D
-
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
---------
D
R
-
P
E
L
ALAVG
L
D
E
---
L
---
V
Y
R
-
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
A
-
3
PsiBlast_PDB
97.72
34%
-109
- C5 -
3A4H
2
CPVDH_PSEAH
A:
[12-403]
-----------------------------------------------------------------------------------------------------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
---
E
D
P
V
R
K
L
AL
P
D
---
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
PRLSKDW
R
H
T
L
P
E
D
Q
R
A
--
D
----
M
P
-----
A
T
P
T
P
--
M
-
M
I
L
-----
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
--
S
V
-----
L
V
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
-----
L
S
D
L
L
E
R
K
---
R
T
E
P
D
D
A
L
L
S
S
L
-----
L
A
-------
V
S
D
--
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
-
P
I
R
F
T
A
E
D
-
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
---------
D
R
-
P
E
L
ALAVG
L
D
E
---
L
---
V
Y
R
-
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
A
-
1
PsiBlast_PDB
97.70
34%
-109
- C5 -
3VRM
2
CPVDH_PSEAH
A:
[12-403]
-----------------------------------------------------------------------------------------------------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
---
E
D
P
V
R
K
L
AL
P
D
---
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
PRLSKDW
R
H
T
L
P
E
D
Q
R
A
--
D
----
M
P
-----
A
T
P
T
P
--
M
-
M
I
L
-----
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
--
V
-----
L
V
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
-----
L
S
D
L
L
E
R
K
---
R
T
EP
D
D
A
L
L
S
S
L
-----
L
A
-------
V
S
D
--
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
-
P
I
R
F
T
A
E
D
-
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
---------
D
R
-
P
E
L
ALAVG
L
D
E
---
L
---
V
Y
R
-
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
A
-
47
PsiBlast_CBE
96.19
31%
-102
- C5 -
4DO1
5
?
C:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
43
PsiBlast_CBE
95.56
31%
-101
- C5 -
4EGM
7
?
D:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
45
PsiBlast_CBE
95.47
31%
-99
- C5 -
4EGM
7
?
B:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGG
F
G
A
C
I
H
A
F
T
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
96
PsiBlast_CBE
95.31
31%
-97
- C5 -
2VZ7
2
PIKC_STRVZ
A:
[32-421]
----------------------------------------------------------------------------------------------------PPVL-
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
GP
A
H
R
V
R
T
P
--
E
G
---
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
PRFS---
K
D
W
R
N
S
T
T
P
L
--
T
----
E
A
-----
E
A
A
L
N
--
H
N
M
L
E
-----
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
-
R
V
W
T
D
A
F
-----
V
F
P
D
D
-
P
A
Q
A
Q
T
A
M
A
E
M
S
G
Y
L
S
----
R
L
I
D
S
K
R
---
G
---
Q
D
G
---
E
D
L
L
S
A
L
V
R
-------
T
S
D
--
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
-
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
-------
R
C
P
D
-
L
A
L
-----
D
V
S
---
P
GE
L
V
W
Y
-
P
N
P
M
I
R
G
L
K
A
L
----------
40
PsiBlast_CBE
95.31
31%
-102
- C5 -
4EGN
7
?
D:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
49
PsiBlast_CBE
95.24
31%
-101
- C5 -
4DNZ
4
?
D:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
138
HHSearch
95.22
31%
-94
- C5 -
4MM0
1
?
A:
[8-399]
-------------------------------------------------------------------------------------------------
A
T
R
-----
H
P
Y
P
F
D
R
A
V
P
T
A
I
P
P
L
Y
E
E
L
R
E
---
T
E
R
V
A
A
I
--
T
M
ATG
D
P
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
-------
P
R
-
F
S
V
R
Q
D
L
--
P
GAPR
L
T
-----
E
M
T
F
E
--
S
-
V
M
T
-----
T
D
P
P
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
M
E
K
K
-
G
A
P
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
E
L
L
G
V
P
M
V
D
V
A
R
F
R
G
W
A
D
T
M
V
-----
S
L
T
G
Y
---------
S
M
E
D
W
T
A
A
R
D
A
L
E
S
Y
L
D
G
L
V
A
A
K
---
R
E
N
--
P
G
S
D
L
L
S
A
L
V
-------
A
T
A
A
-
E
D
N
-
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
F
P
D
R
L
A
E
L
R
R
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
A
G
-
D
G
A
L
F
R
V
T
L
E
D
-
V
T
I
G
D
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
N
W
D
P
R
R
F
D
D
P
T
G
L
R
L
D
R
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
-------
R
F
-
P
R
L
A
L
-----
A
T
D
ESG
L
---
R
W
S
S
P
G
S
M
L
S
G
F
A
E
I
P
V
T
W
------
42
PsiBlast_CBE
95.20
31%
-99
- C5 -
4EGN
6
?
B:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
20
PsiBlast_PDB
95.10
31%
-99
- C5 -
4EGN
5
?
A:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGG
F
G
A
C
I
H
A
F
T
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
48
PsiBlast_CBE
94.93
31%
-98
- C5 -
4DO1
6
?
B:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
38
PsiBlast_CBE
94.86
31%
-100
- C5 -
4EGO
8
?
B:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGGFGAC
I
H
A
FT
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
17
PsiBlast_PDB
94.83
31%
-100
- C5 -
4DNZ
4
?
A:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGG
F
G
A
C
I
H
A
F
T
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
28
PsiBlast_CBE
94.76
33%
-103
- C5 -
3A50
2
CPVDH_PSEAH
B:
[12-403]
-----------------------------------------------------------------------------------------------------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
---
E
D
P
V
R
K
L
AL
P
D
---
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
-------
P
R
L
S
K
D
W
R
H
R
LP
E
----
D
Q
-----
R
A
D
M
P
--
A
-
T
P
T
PMMIL
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
--
V
-----
L
V
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
-----
L
S
D
L
L
E
R
K
---
R
TEP
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-------------
D
G
D
-
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
-
P
I
R
F
T
A
E
D
-
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
---------
D
R
-
P
E
L
ALAVG
L
D
E
---
L
---
V
Y
R
-
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
A
-
70
PsiBlast_CBE
94.74
31%
-96
- C5 -
4UMZ
2
PIKC_STRVZ
A:
[32-421]
----------------------------------------------------------------------------------------------------PPVL-
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
GP
A
H
R
V
R
T
P
--
E
G
---
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
PRFS---
K
D
W
R
N
S
T
T
P
L
--
T
----
E
A
-----
E
A
A
L
N
--
H
N
M
L
E
-----
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
-
R
V
W
T
D
A
F
-----
V
F
P
D
D
-
P
A
Q
A
Q
T
A
M
A
E
M
S
G
Y
L
S
----
R
L
I
D
S
K
R
---
G
---
Q
D
G
---
E
D
L
L
S
A
L
V
R
-------
T
S
D
--
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
-
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
-------
R
C
P
D
-
L
A
L
-----
D
V
S
---
P
GE
L
V
W
Y
-
P
N
P
M
I
R
G
L
K
A
L
----------
19
PsiBlast_PDB
94.73
31%
-100
- C5 -
4EGM
8
?
A:
[24-409]
----------------------------------------------------------------------------------------------------------
I
D
P
F
S
L
D
F
F
D
D
P
Y
P
D
Q
Q
T
L
R
D
---
A
G
P
V
V
Y
L
--
D
K
---
W
N
V
Y
G
V
A
R
Y
A
E
V
H
A
V
L
N
D
-------
P
T
T
F
C
S
S
R
G
V
--
G
----
L
S
DFKKE
K
P
W
R
P
PS
L
-
I
L
E
-----
A
D
P
P
A
H
T
R
P
R
A
V
L
S
K
V
L
S
P
A
T
M
K
T
I
R
D
G
F
A
A
A
A
D
A
K
V
D
E
L
L
Q
--
R
G
C
I
D
A
I
A
D
L
A
E
A
Y
P
L
S
V
F
P
D
A
M
G
L
------------
K
Q
E
G
-----
R
--
E
H
-
L
L
P
Y
A
G
L
V
F
N
A
F
G
P
P
N
E
L
R
Q
T
A
I
E
R
S
A
---
P
---
H
Q
A
Y
V
N
E
Q
C
Q
R
P
N
L
A
PGG
F
G
A
C
I
H
A
F
T
D
T
G
-
E
I
T
P
D
E
A
P
L
L
V
R
S
L
L
S
A
G
L
D
T
T
V
N
G
I
G
A
A
V
Y
C
L
A
R
F
P
G
E
L
Q
R
L
R
S
D
P
T
L
A
R
N
A
F
E
E
A
V
R
F
E
S
P
V
-
Q
T
-
F
F
R
T
T
T
R
E
-
V
E
L
G
G
A
V
I
G
E
G
E
K
V
L
M
F
L
G
S
A
N
R
D
P
R
R
W
S
D
P
D
L
Y
D
I
T
R
K
T
S
G
H
V
G
F
G
S
G
V
H
M
C
V
G
Q
L
V
A
R
L
E
G
E
V
M
L
S
A
L
A
R
-------
K
V
A
A
-
I
D
I
-----
D
G
P
---
V
---
K
R
R
-
F
N
N
T
L
R
G
L
E
S
L
P
V
K
L
T
P
----
94
PsiBlast_CBE
94.72
31%
-97
- C5 -
2VZM
2
PIKC_STRVZ
A:
[32-421]
----------------------------------------------------------------------------------------------------PPVL-
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
GP
A
H
R
V
R
T
P
--
E
G
---
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
PRFS---
K
D
W
R
N
S
T
T
P
L
--
T
----
E
A
-----
E
A
A
L
N
--
H
N
M
L
E
-----
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
-
R
V
W
T
D
A
F
-----
V
F
P
D
D
-
P
A
Q
A
Q
T
A
M
A
E
M
S
G
Y
L
S
----
R
L
I
D
S
K
R
---
G
---
Q
D
G
---
E
D
L
L
S
A
L
V
R
-------
T
S
D
--
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
-
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
-------
R
C
P
D
-
L
A
L
-----
D
V
S
---
P
GE
L
V
W
Y
-
P
N
P
M
I
R
G
L
K
A
L
----------
23
PsiBlast_CBE
94.71
33%
-103
- C5 -
3A51
5
CPVDH_PSEAH
C:
[12-402]
-----------------------------------------------------------------------------------------------------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
---
E
D
P
V
R
K
L
AL
P
D
---
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
-------
P
R
L
S
K
D
W
R
H
R
LP
E
----
D
Q
-----
R
A
D
M
P
--
A
-
T
P
T
PMMIL
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
--
V
-----
L
V
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
-----
L
S
D
L
L
E
R
K
---
R
TEP
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-------------
D
G
D
-
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
-
P
I
R
F
T
A
E
D
-
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
---------
D
R
-
P
E
L
ALAVG
L
D
E
---
L
---
V
Y
R
-
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
--
90
PsiBlast_CBE
92.62
31%
-95
- C5 -
3ZPI
13
PIKC_STRVZ
A:
[31-421]
----------------------------------------------------------------------------------------------------SPPVL
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
GP
A
H
R
V
R
T
P
--
E
G
---
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
PRFS---
K
D
W
R
N
S
T
T
P
L
--
T
----
E
A
-----
E
A
A
L
N
--
H
N
M
L
E
-----
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
-
R
V
W
T
D
A
F
-----
V
F
P
D
D
-
P
A
Q
A
Q
T
A
M
A
E
M
S
G
Y
L
S
----
R
L
I
D
S
K
R
---
G
---
Q
D
G
---
E
D
L
L
S
A
L
V
R
-------
T
S
D
--
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
-
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
-------
R
C
P
D
-
L
A
L
-----
D
V
S
---
P
GE
L
V
W
Y
-
P
N
P
M
I
R
G
L
K
A
L
----------
7
PsiBlast_PDB
80.34
35%
-106
- C5 -
1JIP
2
CPXJ_SACEN
A:
[91-399]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
R
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------
11
PsiBlast_PDB
80.07
35%
-104
- C5 -
1JIN
2
CPXJ_SACEN
A:
[91-399]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
S
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------
14
PsiBlast_PDB
79.71
34%
-106
- C5 -
1JIO
2
CPXJ_SACEN
A:
[91-399]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
R
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------
8
PsiBlast_PDB
79.68
35%
-105
- C5 -
1Z8P
3
CPXJ_SACEN
A:
[92-400]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
R
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------
13
PsiBlast_PDB
79.46
34%
-104
- C5 -
1Z8Q
3
CPXJ_SACEN
A:
[92-400]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
R
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
T
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------
15
PsiBlast_PDB
79.36
34%
-103
- C5 -
1Z8O
3
CPXJ_SACEN
A:
[92-400]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
R
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------
10
PsiBlast_PDB
78.96
35%
-104
- C5 -
1EUP
3
CPXJ_SACEN
A:
[91-399]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
G
V
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
MDPE
R
A
E
Q
R
-
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
-----
T
E
P
---
G
---
D
D
L
L
S
A
L
I
S
V
------------
Q
D
D
--
D
D
G
-
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
-
T
T
R
F
A
A
E
E
-
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
ALSL
G
I
D
A
-
D
D
V
-----
V
----------
W
R
-
R
S
L
L
L
R
G
I
D
H
L
P
V
--------