@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2298: (2016-05-09 )
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR
Atome Classification :
(23 SA)
-.......--..-10...--......20........30........40........50........60-------........70.---..---.---....80....--------.--..---.-------------90..-------.-------.-------....-----100-------........110.......120.-----------------..----....130.......140.......150---........160---.-.----......170.......-180........190-.---......200.......210-----...--.------.------.--.---.220--.---.----.----...----...230......-..240..-....---.250-.......260..-----.-...-.-270.......280...-.--...290.......300....-...310.......320.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
K
Y
LDVD--GI-G-
Q
V
S
--RI
G
L
G
T
W
QFGSREWGYGDRYAT
G
A
A
R
D
I
V
K
R
A
R
ALG
V
T
L
FDT
A
E
IYGL-------G
K
S
E
R
I
L
G
E
AL---GD---D---R
T
E
V
V
V
A
SKV--------F--PV---A-------------P
F
P
A
-------
V
-------
I
-------KN
R
E
-----
R
A--------SAR
R
L
QLNRI
P
L
Y
Q
IHQPNPVV-----------------P
D
----
S
V
I
M
P
G
M
R
D
L
LDSGDIGAAGVSNY
S
L
----
A
R
W
RKADAAL----G-R----PVVSN
Q
V
H
F
SLAH
P
D
A
-
L
E
-
D
LV
P
F
A
E
LEN
R
-
I
---
V
I
A
Y
S
P
L
A
Q
G
L
LGGKYGL------ENR--P------G------G--
V
---
R
A
----L---
N
----
P
----LFG----T
E
N
L
-
R
R
I
E
P
L
L
-
A
T
L
R
A
I
A
-VDVD---AK
P
A
-
Q
V
A
L
A
W
L
I
SLP
G
-----
V
-
V
AI-P-GASSV
E
Q
L
E
F
N
V
A
A
A
D
-
I
--
E
L
SAQS
R
D
A
L
T
D
A
A
R
AFRPV-ST
G
R
F
L
T
D
M
V
R
E
K
VSRR
36
HHSearch
98.57
31%
-90
- C2 -
1PYF
3
IOLS_BACSU
A:
[2-310]
--
K
K
A
K
L
G
--
K
S
D
L
-
Q
V
F
--
P
I
G
L
G
T
N
A
V
G
G
H
N
L
-
Y
P
-
N
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
---
R
E
F
--
N
---
R
E
D
V
V
I
A
T
K
A
--------
A
--
H
R
---
K
Q
GN
D
F
V
F
D
-----
N
S
P
D
-------
F
-------
L
-------
K
K
S
V
-----
D
E
--------
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-----------------
P
K
----
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
----
E
Q
L
K
E
A
N
K
D
-------
G
----
L
V
D
V
L
Q
G
E
Y
N
L
L
N
R
E
A
-
E
K
-
T
F
F
P
Y
T
K
E
H
N
I
-
S
---
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
------
D
T
T
F
-
P
E-----
G
------
D
--
L
---
R
N
----
E
---
Q
----
E
----
H
F
K
----
G
E
R
F
-
K
E
N
I
R
K
V
-
N
K
L
A
P
I
A
-
E
K
H
N
---
V
D
I
P
-
H
I
V
L
A
W
Y
L
A
R
P
E
-----
I
D
I
L
I
-
P
-
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
-----------------------
33
HHSearch
96.60
31%
-87
- C2 -
1PZ1
1
GS69_BACSU
A:
[1-314]
-
M
E
Y
T
S
I
A
DT
G
--
I
-
E
A
S
--
R
I
G
L
G
T
W
A
I
G
G
T
M
W
G
---
G
T
D
E
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
F
-------
G
Q
S
E
E
I
V
G
K
A
I
---
K
E
Y
M-
K
---
R
D
Q
V
I
L
A
T
K
T
--------
A
--
L
D
---
W
K
NN
Q
L
F
R
H
-----
A
N
R
A
-------
R
-------
I
-------
V
E
E
V
-----
E
N
--------
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
V
-----------------
P
I
----
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
I
----
E
Q
M
D
T
F
R
A
V
-------
A
----
P
L
H
T
I
Q
P
P
Y
N
L
F
E
R
E
M
-
E
E
-
S
V
L
P
Y
A
K
D
N
K
I
-
T
---
T
L
L
Y
G
S
L
C
R
G
L
L
T
G
K
M
T
E
------
E
Y
T
--
F
E
-----
G
D-----
D
--
L
---
R
N
----
H
---
D
----
P
----
K
F
Q
----
K
P
R
F
-
K
E
Y
L
S
A
V
-
N
Q
L
D
K
L
A
K
T
R
Y
G
---
K
S
V
I
-
H
L
A
V
R
W
I
L
D
Q
P
G
-----
A
D
I
A
L
-
W
-
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
L
N
S
E
D
Q
K
D
I
N
T
I
L
E
N
T
I
--------------------
5
PsiBlast_PDB
95.85
31%
-92
- C2 -
1PZ0
2
IOLS_BACSU
A:
[12-301]
---------------
Q
V
F
--
P
I
G
L
G
T
N
A
V
G
G
H
N
L
Y
P
N
L
N
E
E
T
G
--
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
---
R
E
F
--
N
---
R
E
D
V
V
I
A
T
K
A
A
H
R
K
Q
GN
D
F
--
V
F
---
D
-------------
N
S
P
D
-------
F
-------
L
-------
K
K
S
V
-----
D
E
--------
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-----------------
P
K
----
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
----
E
Q
L
K
E
A
N
K
D
G
----
L
-
V
----
D
V
L
--
Q
G
E
Y
N
L
L
N
R
E
A
-
E
K
-
T
F
F
P
Y
T
K
E
H
N
I
-
S
---
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
------
D
T
T
F
P
E
------
G
------
D
--
L
---
R
N
----
E
---
Q
----
E
----
H
F
K
GE
R
F
K
E
N
I
-
R
K
V
N
K
L
A
-
P
I
A
E
K
H
N
-
V
D
I
-------
P
-
H
I
V
L
A
W
Y
L
A
R
P
E
-----
I
D
I
L
I
-
P
-
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
L
S
Q
E
D
--------------------------------
4
PsiBlast_PDB
94.53
31%
-93
- C2 -
1PYF
2
IOLS_BACSU
A:
[12-301]
---------------
Q
V
F
--
P
I
G
L
G
T
N
A
V
G
G
H
N
L
Y
P
N
L
N
E
E
T
G
--
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
---
R
E
F
--
N
---
R
E
D
V
V
I
A
T
K
A
A
H
R
K
Q
GN
D
F
--
V
F
---
D
-------------
N
S
P
D
-------
F
-------
L
-------
K
K
S
V
-----
D
E
--------
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-----------------
P
K
----
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
----
E
Q
L
K
E
A
N
K
D
G
----
L
-
V
----
D
V
L
--
Q
G
E
Y
N
L
L
N
R
E
A
-
E
K
-
T
F
F
P
Y
T
K
E
H
N
I
-
S
---
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
------
D
T
T
F
P
E
------
G
------
D
--
L
---
R
N
----
E
---
Q
----
E
----
H
F
K
G
E
R
F
K
E
N
I
-
R
K
V
N
K
L
A
-
P
I
A
E
K
H
N
-
V
D
I
-------
P
-
H
I
V
L
A
W
Y
L
A
R
P
E
-----
I
D
I
L
I
-
P
-
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
L
S
Q
E
D
--------------------------------
27
HHSearch
92.04
27%
-84
- C2 -
3N2T
-
?
A:
[3-327]
-
S
D
T
I
R
I
P
G-
I
D
-
T
-
P
L
S
--
R
V
A
L
G
T
W
A
I
G
G
W
M
W
G
---
G
P
D
D
D
N
G
V
R
T
I
H
A
A
L
D
E
G
I
N
L
I
D
T
A
P
V
Y
G
F
-------
G
H
S
E
E
I
V
G
R
A
L
---
A
E
---
K
---
P
N
K
A
H
V
A
T
K
L
--------
G
--
L
H
---
W
V
G
EDEKN
M
K
V
F
R
D
S
R
P
A
-------
R
-------
I
-------
R
K
E
V
-----
E
D
--------
S
L
R
R
L
R
V
E
T
I
D
L
E
Q
I
H
W
P
D
D
K
T
-----------------
P
I
----
D
E
S
A
R
E
L
Q
K
L
H
Q
D
G
K
I
R
A
L
G
V
S
N
F
S
P
----
E
Q
M
D
I
F
R
E
V
-------
A
----
P
L
A
T
I
Q
P
P
L
N
L
F
E
R
T
I
-
E
K
-
D
I
L
P
Y
A
E
K
H
N
A
-
V
---
V
L
A
Y
G
A
L
C
R
G
L
L
T
G
K
M
N
R
------
D
T
T
F
-
P
------
K
D-----
D
--
L
---
R
S
----
N
---
D
----
P
----
K
F
Q
----
K
P
N
F
-
E
K
Y
L
A
A
M
-
D
E
F
E
K
L
A
-
E
K
R
G
---
K
S
V
M
-
A
F
A
V
R
W
V
L
D
Q
G
P
-----
V
-
I
A
L
-
W
-
G
A
R
K
P
G
Q
V
S
G
V
K
D
V
F
G
-
W
--
S
L
T
D
E
E
K
K
A
V
D
D
I
L
A
R
H
V
P
N
P
I
D
P
T
F
M
A
----------
28
HHSearch
91.34
28%
-79
* C2 *
1LQA
1
TAS_ECOLI
A:
[1-342]
-
M
Q
Y
H
R
I
P
HS
S
--
L
-
E
V
S
--
T
L
G
L
G
T
M
T
F
G
E
Q
-------
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
PPRPETQ
G
L
T
E
T
Y
V
G
N
W
L
---
A
K
H
G-
S
---
R
E
K
L
I
I
A
S
K
V
--------
S
--
G
P
---
S
RNNDKGIRPDQA-
L
D
R
K
-------
N
-------
I
-------
R
E
A
L
-----
H
D
--------
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
NCFGKL
G
Y
S
W
T
DSAPAV
S
L
----
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
----
F
G
V
M
R
Y
L
H
L
A
D
K
H
-
D
L
P
----
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
S
F
-
E
V
-
G
L
A
E
V
S
Q
Y
E
G
V
-
E
---
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
------
G
A
K
--
P
------
A
------
G
--
A
---
R
N
T
---
L
---
F
----
S
----
R
F
T
----
R
Y
S
G
-
E
Q
T
Q
K
A
V
-
A
A
Y
V
D
I
A
-
R
R
H
G
---
L
D
P
A
-
Q
M
A
L
A
F
V
R
R
Q
P
F
-----
V
A
S
T
L
-
L
-
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
--------------------
34
HHSearch
91.31
34%
-88
- C2 -
5C7H
1
?
A:
[5-273]
-
I
P
T
I
A
F
P
--
D
G
-
R
-
K
V
P
--
A
L
G
Q
G
T
W
R
M
G
E
N
R
---
A
---
K
T
A
D
E
V
R
S
L
Q
T
G
L
D
L
G
M
T
L
I
D
T
A
E
M
Y
G
D
-------
G
A
A
E
R
I
V
G
E
A
I
---
K
G
---
R
---
R
D
E
A
F
V
V
S
K
V
--------
L
--
P
S
---
N
-------------
A
S
R
A
-------
G
-------
T
-------
V
A
A
C
-----
E
R
--------
S
L
R
N
L
G
I
D
C
V
D
L
Y
L
L
H
W
R
G
G
Y
------------------
P
L
----
A
E
T
V
A
A
F
E
E
L
K
K
A
G
K
I
R
A
W
G
V
S
N
F
D
V
----
D
D
M
E
E
L
S
A
V
P
D---
G
-
G
----
N
V
A
A
N
Q
V
L
Y
N
L
A
R
R
G
I
-
E
F
-
D
L
L
P
R
C
R
A
Q
G
V
-
P
---
V
M
A
Y
S
P
L
D
E
G
R
L
L
H
D
---------------------------------------------------------------------------
A
D
L
I
H
I
A
-
K
A
H
Q
---
A
T
P
A
-
Q
V
A
L
A
F
L
K
T
C
S
G
-----
V
-
I
S
I
-
P
-
K
T
G
S
P
E
R
A
R
E
N
R
D
A
M
D
-
I
--
H
L
T
T
E
N
L
A
E
L
D
R
H
F
P
P
P
R
--------------------
9
PsiBlast_PDB
89.59
32%
-91
- C2 -
4XAP
-
?
A:
[15-271]
---------------
K
V
P
--
A
L
G
Q
G
T
W
R
M
G
E
------
N
R
A
K
T
A
D
E
V
R
S
L
Q
T
G
L
D
L
G
M
T
L
I
D
T
A
E
M
Y
G
D
-------
G
A
A
E
R
I
V
G
E
A
I
---
K
G
---
R
---
R
D
E
A
F
V
V
S
K
V
--------
L
--
P
S
N--
A
-------------
S
R
A
G
-------
T
-------
V
-------
A
A
C
E
-----
R
---------
S
L
R
N
L
G
I
D
C
V
D
L
Y
L
L
H
W
R
G
G
-
Y
-----------------
P
L
----
A
E
T
V
A
A
F
E
E
L
K
K
A
G
K
I
R
A
W
G
V
S
N
F
D
V
----
D
D
M
E
E
L
S
A
V
P
D---
G
-
G
----
N
V
A
A
N
Q
V
L
Y
N
L
A
R
R
G
I
-
E
F
-
D
L
L
P
R
C
R
A
Q
G
V
-
P
---
V
M
A
Y
S
P
L
D
E
G
R
L
-----
L
------
H
D
----------------------------------------------------------------
A
D
L
I
H
I
A
-
K
A
H
Q
---
A
T
P
A
-
Q
V
A
L
A
F
L
K
T
C
S
G
-----
V
-
I
S
I
-
P
-
K
T
G
S
P
E
R
A
R
E
N
R
D
A
M
D
-
I
--
H
L
T
T
E
N
---
L
A
E
L
D
R
H
F
P
P
-------------------
38
HHSearch
89.24
28%
-75
- C2 -
3LUT
1
KCAB2_RAT
A:
[37-360]
-
Q
F
Y
R
N
L
G
KS
G
--
L
-
R
V
S
--
C
L
G
L
G
T
W
V
T
F
G
G
------
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
---
K
K
K
GW
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
--
W
G
---
G
KAETERG------
L
S
R
K
-------
H
-------
I
-------
I
E
G
L
-----
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
-
I
----
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
-
Q
L
P
E
L
F
H
K
I
G
V
-
G
---
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
------
Y
------
S
------
R
A
----
S
LKG
Y
----
Q
W
L
K
D
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
S
S
V
L
-
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
-------------------
50
Fugue
89.17
27%
-85
- C2 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
L
G
--
K
S
-
G
L
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
---
K
K
K
GW
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
--
W
G
---
G
-------------
K
A
E
T
ERGLS
R
K
H
-------
I
-------
I
E
G
L
-----
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
NLI
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
-
G
---
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
Y
S
R
A
S
--
L
------
K
------
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
-
S
S
V
-
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
-------------------
6
PsiBlast_PDB
88.83
31%
-88
- C2 -
1PZ1
1
GS69_BACSU
A:
[12-288]
---------------
E
A
S
--
R
I
G
L
G
T
W
A
I
G
G
T
M
W
G
G
T
D
E
---
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
F
-------
G
Q
S
E
E
I
V
G
K
A
I
---
K
E
Y
M-
K
---
R
D
Q
V
I
L
A
T
K
T
--------
A
--
L
D
---
W
-------------
K
N
N
Q
-------
L
-------
F
-------
R
H
A
N
-----
R
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
V
-----------------
P
I
----
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
I
----
E
Q
M
D
T
F
R
A
V
A
-----------
P
L
H
T
I
Q
P
P
Y
N
L
F
E
R
E
M
-
E
E
-
S
V
L
P
Y
A
K
D
N
K
I
-
T
---
T
L
L
Y
G
S
L
C
R
G
L
L
T
G
K
M
T
E
------
E
Y
T
--
F
------
E
------
G
DD
L
---
R
N
----
H
---
D
----
P
----
K
F
Q
----
K
P
R
F
-
K
E
Y
L
S
A
V
-
N
Q
L
D
K
L
A
-
K
T
R
Y
---
G
K
S
V
I
H
L
A
V
R
W
I
L
D
Q
P
G
-----
A
D
I
A
L
-
W
-
G
A
R
K
P
G
Q
L
E
-------------------------------------------------
32
HHSearch
88.81
27%
-80
- C2 -
3EAU
3
KCAB2_RAT
A:
[3-324]
-
Q
F
Y
R
N
L
G
KS
G
--
L
-
R
V
S
--
C
L
G
L
G
T
W
V
T
F
G
G
------
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
---
K
K
K
GW
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
--
W
G
---
G
KAETERG------
L
S
R
K
-------
H
-------
I
-------
I
E
G
L
-----
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
-
I
----
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
-
Q
L
P
E
L
F
H
K
I
G
V
-
G
---
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
------
Y
------
S
RA
S
---
L
K
GY
Q
W
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
S
S
V
L
-
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
---------------------
49
Fugue
88.56
27%
-79
- C2 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
L
G
--
K
S
-
G
L
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
---
K
K
---
K
GWR
R
S
S
L
V
I
T
T
K
I
--------
F
--
W
G
---
G
-------------
K
A
E
T
-------
E
-------
R
GLS
R
K
H
I
I
E
G
L
-----
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
---------------------NTP
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
NLI
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
---
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
------
Y
S
RASLK
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
S
S
V
L
-
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
-------------------
18
PsiBlast_PDB
88.55
28%
-93
- C2 -
4JTD
1
KCAB2_RAT
A:
[14-305]
---------------
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
WG
G
K
---
A
-------------
E
T
E
R
-------
G
-------
L
-------
S
R
K
H
I
I
E
G
L
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
NLI
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
-
V
Q
L
P
--
E
L
F
H
K
-
I
GVG
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
YSRASL
K
------
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
-
S
S
V
L
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
----------------------------------------
19
PsiBlast_PDB
88.50
28%
-90
- C2 -
3EAU
3
KCAB2_RAT
A:
[14-305]
---------------
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
--
W
G
---
G
-------------
K
A
E
T
-------
E
RGLS
R
K
H
I
-------
I
E
G
L
-----
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
NLI
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
-
V
Q
L
P
--
E
L
F
H
K
-
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
YSRASL
K
------
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
-
S
S
V
L
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
----------------------------------------
8
PsiBlast_PDB
88.13
32%
-93
- C2 -
5C7H
1
?
A:
[15-271]
---------------
K
V
P
--
A
L
G
Q
G
T
W
R
M
G
E
------
N
R
A
K
T
A
D
E
V
R
S
L
Q
T
G
L
D
L
G
M
T
L
I
D
T
A
E
M
Y
G
D
-------
G
A
A
E
R
I
V
G
E
A
I
---
K
G
---
R
---
R
D
E
A
F
V
V
S
K
V
--------
L
--
P
S
N--
A
-------------
S
R
A
G
-------
T
-------
V
-------
A
A
C
E
-----
R
---------
S
L
R
N
L
G
I
D
C
V
D
L
Y
L
L
H
W
R
G
G
-
Y
-----------------
P
L
----
A
E
T
V
A
A
F
E
E
L
K
K
A
G
K
I
R
A
W
G
V
S
N
F
D
V
----
D
D
M
E
E
L
S
A
V
P
D---
G
-
G
----
N
V
A
A
N
Q
V
L
Y
N
L
A
R
R
G
I
-
E
F
-
D
L
L
P
R
C
R
A
Q
G
V
-
P
---
V
M
A
Y
S
P
L
D
E
G
R
L
-----
L
------
H
D
----------------------------------------------------------------
A
D
L
I
H
I
A
-
K
A
H
Q
---
A
T
P
A
-
Q
V
A
L
A
F
L
K
T
C
S
G
-----
V
-
I
S
I
-
P
-
K
T
G
S
P
E
R
A
R
E
N
R
D
A
M
D
-
I
--
H
L
T
T
E
N
---
L
A
E
L
D
R
H
F
P
P
-------------------
12
PsiBlast_PDB
87.84
28%
-91
- C2 -
3EB3
2
KCAB2_RAT
A:
[14-305]
---------------
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
--
A
G
---
G
-------------
K
A
E
T
-------
E
RGLS
R
K
H
I
-------
I
E
G
L
-----
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
NLI
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
-
V
Q
L
P
--
E
L
F
H
K
-
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
YSRASL
K
------
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
-
S
S
V
L
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
----------------------------------------
17
PsiBlast_PDB
87.62
28%
-93
- C2 -
4JTC
1
KCAB2_RAT
A:
[14-305]
---------------
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
WG
G
K
---
A
-------------
E
T
E
R
-------
G
-------
L
-------
S
R
K
H
I
I
E
G
L
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
-
V
Q
L
P
--
E
L
F
H
K
-
I
GVG
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
YSRASL
K
------
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
-
S
S
V
L
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
----------------------------------------
41
HHSearch
87.57
25%
-77
- C2 -
2BP1
2
ARK72_HUMAN
A:
[38-358]
------------------RV
A
S
V
L
G
T
M
E
M
G
R
R
-------
M
D
A
P
A
S
A
A
A
V
R
A
F
L
E
R
G
H
T
E
L
D
T
A
F
M
Y
S
D
-------
G
Q
S
E
T
I
L
G
G
L
G
---
L
G
LGG
G
---
D
C
R
V
K
I
A
T
K
A
--------
N
--
P
W
DGK
S
-------------
L
K
P
D
-------
S
-------
V
-------
R
S
Q
L
-----
E
T
--------
S
L
K
R
L
Q
C
P
Q
V
D
L
F
Y
L
H
A
P
D
H
G
T
-----------------
P
V
----
E
E
T
L
H
A
C
Q
R
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
A
S
----
W
E
V
A
E
I
C
T
L
C
K
S
N
-
G
W
I
----
L
P
T
V
Y
Q
G
M
Y
N
A
T
T
R
Q
V
-
E
T
-
E
L
F
P
C
L
R
H
F
G
L
-
R
---
F
Y
A
Y
N
P
L
A
G
G
L
L
T
G
K
Y
K
Y
------
E
D
K
--
D
------
G
------
K
--
Q
PVG
R
F
----
F
---
G
NSW
A
E
----
T
Y
R
----
N
R
F
W
K
E
H
H
F
E
A
I
A
L
V
E
K
A
L
Q
-
A
A
Y
G
ASA
P
S
V
T
-
S
A
A
L
R
W
M
Y
H
H
S
Q
LQGAH
G
D
A
V
I
-
L
-
G
M
S
S
L
E
Q
L
E
Q
N
L
A
A
T
E
E
G
--
P
L
E
P
A
V
V
D
A
F
N
Q
A
W
H
L
V
A
-
H
-
E
C
P
N
Y
------------
15
PsiBlast_PDB
87.57
28%
-95
- C2 -
3LNM
1
KCAB2_RAT
A:
[14-305]
---------------
R
V
S
--
C
L
G
L
G
T
W
V
------
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
---
R
S
S
L
V
I
T
T
K
I
--------
F
WG
G
K
---
A
-------------
E
T
E
R
-------
G
-------
L
-------
S
R
K
H
I
I
E
G
L
K
A
--------
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
----
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
----
M
E
I
M
E
A
Y
S
V
A
----
R
-
Q
F
NLI
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
-
V
Q
L
P
--
E
L
F
H
K
-
I
GVG
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
------
G
I
P
--
P
YSRASL
K
------
G
--
Y
---
Q
W
----
L
---
K
----
D
----
K
I
L
----
S
E
E
G
-
R
R
Q
Q
A
K
L
-
K
E
L
Q
A
I
A
-
E
R
L
G
---
C
T
L
P
-
Q
L
A
I
A
W
C
L
R
N
E
G
-----
V
-
S
S
V
L
L
-
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
----------------------------------------
10
PsiBlast_PDB
61.67
32%
-9
- C2 -
4PMJ
2
?
A:
[15-271]
---------------
K
V
P
--
A
L
G
Q
G
T
W
R
M
G
E
------
N
R
A
K
T
A
D
E
V
R
S
L
Q
T
G
L
D
L
G
M
T
L
I
D
T
A
E
M
Y
G
D
-------
G
A
A
E
R
I
V
G
E
A
I
---
K
G
---
R
---
R
D
E
A
F
V
V
S
K
V
--------
L
--
P
S
N--
A
-------------
S
R
A
G
-------
T
-------
V
-------
A
A
C
E
-----
R
---------
S
L
R
N
L
G
I
D
C
V
D
L
Y
L
L
H
W
R
G
G
-
Y
-----------------
P
L
----
A
E
T
V
A
A
F
E
E
L
K
K
A
G
K
I
R
A
W
G
V
S
N
F
D
V
----
D
D
M
E
E
L
S
A
V
P
D---
G
-
G
----
N
V
A
A
N
Q
V
L
Y
N
L
A
R
R
G
I
-
E
F
-
D
L
L
P
R
C
R
A
Q
G
V
-
P
---
V
M
A
Y
S
P
L
D
E
G
R
L
-----
L
------
H
D
----------------------------------------------------------------
A
D
L
I
H
I
A
-
K
A
H
Q
---
A
T
P
A
-
Q
V
A
L
A
F
L
K
T
C
S
G
-----
V
-
I
S
I
-
P
-
K
T
G
S
P
E
R
A
R
E
N
R
D
A
M
D
-
I
--
H
L
T
T
E
N
---
L
A
E
L
D
R
H
F
P
P
-------------------
37
HHSearch
59.31
32%
2
- C2 -
4WGH
2
?
A:
[25-298]
-
K
K
T
V
R
F
G
--
E
Q
-
A
-
A
V
P
--
A
I
G
L
G
T
W
Y
M
G
E
H
---
A
---
A
Q
R
Q
Q
E
V
A
A
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
A
D
-------
G
G
A
E
E
V
V
G
Q
A
I
---
R
G
---
L
---
R
D
R
V
V
L
V
S
K
V
--------
Y
--
P
W
---
H
-------------
A
G
K
A
-------
A
-------
M
-------
H
R
A
C
-----
E
N
--------
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
W
R
G
D
I
------------------
P
L
----
Q
E
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
T
----
E
D
M
Q
A
L
W
R
T
A
D---
G
-
E
----
H
C
A
T
N
Q
V
L
Y
H
L
A
S
R
G
I
-
E
Y
-
D
L
L
P
W
C
Q
Q
H
S
L
-
P
---
V
M
A
Y
C
P
L
A
Q
A
G
R
L
R
D
G
------------------------------------------------------
L
F
---------------
Q
H
-
S
D
I
I
N
M
A
-
N
A
R
G
---
I
T
V
A
-
Q
L
L
L
A
W
V
I
R
H
P
G
-----
V
-
L
A
I
-
P
-
K
A
A
S
I
E
H
V
V
Q
N
A
A
A
L
D
-
I
--
V
L
S
G
E
E
L
A
Q
L
D
R
L
Y
P
P
P
Q
--------------------
7
PsiBlast_PDB
55.70
33%
13
- C2 -
4WGH
2
?
A:
[36-286]
----------------
V
P
--
A
I
G
L
G
T
W
Y
M
G
E
H
A
---
A
Q
R
Q
Q
E
V
A
A
---
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
A
D
-------
G
G
A
E
E
V
V
G
Q
A
I
---
R
G
---
L
---
R
D
R
V
V
L
V
S
K
V
--------
Y
--
P
W
---
H
-------------
A
G
K
A
-------
A
-------
M
-------
H
R
A
C
-----
E
N
--------
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
W
R
G
D
-
I
-----------------
P
L
----
Q
E
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
T
E
D
M
Q
A
L
W
R
T
A
D
-------
G
-
E
----
H
C
A
T
N
Q
V
L
Y
H
L
A
S
R
G
I
-
E
Y
-
D
L
L
P
W
C
Q
Q
H
S
L
-
P
---
V
M
A
Y
C
P
L
A
Q
A
--------------------------
G
------
R
--
L
---
R
---------
D
----
G
----
L
F
Q
----
H
S
D
I
-
I
N
M
-----
A
N
A
R
G
I
T
-
V
---------
A
-
Q
L
L
L
A
W
V
I
R
H
P
G
-----
V
-
L
A
I
-
P
-
K
A
A
S
I
E
H
V
V
Q
N
A
A
A
L
D
-
I
--
V
L
S
G
E
E
--------------------------------