@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2334: (2016-05-09 )
MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVVLPDFGERYLSTPLFADVAD
Atome Classification :
(70 SA)
------------------------------------.........10........20--.--..--.----.-------.---..30........40........50........-60..--.-.--...-.70........80........90........100.......110.....---..---120.----.-.......130.....-..-.140.......150..-.....160......-.-170.......180.......190...-...--..--200......-.-----210---.-----.------..---.------...220........230.......240.......250.......260.......270.......280.--.......290.......300.......310---------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------M
S
I
A
E
D
I
T
Q
L
IGRT
P
L
V
R
L
R
R--V--TD--
G
----
A
-------
V
---
A
D
I
V
A
K
L
EFFN
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
QAG-LIKP--
D
-
T
--
I
I
L
-
E
PTSGNT
G
I
A
L
A
M
V
C
A
ARG
Y
R
C
V
LTMP
E
T
M
S
L
E
R
R
M
L
L
R
A
YG
A
E
L
I
LTP---GA---D--G----M-S
G
A
I
A
K
A
E
E
-
L
A
KT
D
-
Q
R-YFV
P
Q
QFENPANP
A
I
H
-
R
VT
T
A
E
E
V
W
RDTDG-
K
-
V
D
I
V
V
A
GVGTG
G
T
I
T
G
V
A
Q
V
I
K
-ERK-PSA--
R
F
--
V
A
VEPAA
S
P
-
V
-----L-S---G-----G------QK---G------PHPIQ-GIGAGFVPPVL
D
Q
D
L
V
D
E
I
I
TVGN
E
D
A
L
N
V
A
R
R
L
A
REE
G
L
L
V
G
ISSG
A
A
T
V
A
A
L
Q
V
ARR-PE--NA
G
K
L
I
V
V
VLPDF
G
E
R
Y
LSTPLFADVAD-----------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.87
100%
-95
- C3 -
2Q3D
2
CYSK_MYCTU
A:
[4-309]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
V
---
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
--
G
----
M
-
S
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
Q
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
E
R
K
-
P
S
A
--
R
F
--
V
A
V
E
P
A
A
S
P
-
V
-----
L
-
S
---
G
-----
G
------
Q
K
---
G
------
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.99
100%
-103
- C3 -
3ZEI
4
CYSK_MYCTU
A:
[1-300]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
V
---
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
--
G
----
M
-
S
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
Q
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
E
R
K
-
P
S
A
--
R
F
--
V
A
V
E
P
A
A
S
P
-
V
-----
L
-
S
---
G
-----
G
------
Q
K
---
G
------
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.87
99%
-100
- C3 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
V
---
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
--
G
----
M
-
S
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
Q
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
E
R
K
-
P
S
A
--
R
F
--
V
A
V
E
P
A
A
S
P
-
V
-----
L
-
S
---
G
-----
G
------
Q
K
---
G
------
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
94.26
98%
-100
- C3 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
V
---
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
--
G
----
M
-
S
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
Q
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
E
R
K
-
P
S
A
--
R
F
--
V
A
V
E
P
A
A
S
P
V
L
-----
S
-
G
---
G
------------
Q
K
---
G
------
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.87
85%
-107
- C3 -
3RR2
-
?
A:
[1-299]
------------------------------------
M
T
I
A
E
N
I
T
Q
L
I
G
G
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
A
---
A
D
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
----------------
M
-
A
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
D
R
-
Y
F
I
P
Q
Q
F
E
N
P
A
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
Q
R
R
-
P
S
A
--
Q
F
--
V
A
V
E
P
A
A
S
P
-
V
-------------------------
K
---
G
------
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
V
G
I
S
S
G
A
A
V
W
A
A
R
E
L
A
H
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.17
64%
-94
- C3 -
4LMA
3
?
A:
[8-320]
------------------------------------
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
--
I
P
Q
A
E
--
G
----
C
-------
L
---
G
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
-
L
I
N
P
--
E
-
T
--
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
--
G
----
M
-
K
G
A
I
L
R
A
Q
Q
-
I
V
D
S
I
-
P
G
-
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
-
Q
-
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
-
S
R
K
-
P
S
F
--
Q
V
--
V
A
V
E
P
F
N
S
P
-
V
-----
I
-
S
---
G
-----
G
------
N
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
R
-
P
E
--
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
N
I
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.03
84%
-114
- C3 -
4I1Y
2
?
B:
[5-301]
------------------------------------
M
T
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
A
---
A
D
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
--
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
E
--
G
----
M
-
A
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
D
R
-
Y
F
I
P
Q
------
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
Q
R
R
-
P
S
A
--
Q
F
--
V
A
V
E
P
A
---------------------------------------------------------
L
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
F
G
I
S
S
G
A
A
V
W
A
A
R
E
L
A
H
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.71
66%
-86
- C3 -
4LMB
3
?
A:
[8-317]
------------------------------------
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
V
--
A
E
--
G
----
V
-------
K
---
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
-
L
I
H
P
--
D
K
T
--
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
---
G
S
---
Q
--
G
----
M
-
E
G
A
I
T
R
A
E
E
-
I
V
E
N
T
-
P
N
-
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
D
G
-
L
-
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
-
P
R
R
-
P
Q
F
--
Q
A
--
I
A
V
E
P
S
N
S
P
-
V
-----
L
-
S
---
G
-----
G
------
Q
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
R
-
P
E
--
N
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.34
64%
-91
- C3 -
4LMA
2
?
B:
[8-319]
------------------------------------
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
--
I
PQ
A
E
--
G
----
C
-------
L
---
G
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
-
L
I
N
P
--
E
-
T
--
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
--
G
----
M
-
K
G
A
I
L
R
A
Q
Q
-
I
V
D
S
I
-
P
G
-
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
-
Q
-
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
-
S
R
K
-
P
S
F
--
Q
V
--
V
A
V
E
P
F
N
S
P
-
V
-----
I
-
S
---
G
-----
G
------
N
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
R
-
P
E
--
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
N
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.13
84%
-111
- C3 -
4I1Y
2
?
A:
[5-301]
------------------------------------
M
T
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
A
---
A
D
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
E
--
G
----
M
-
A
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
D
R
-
Y
F
I
P
Q
------
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
Q
R
R
-
P
S
A
--
Q
F
--
V
A
V
E
P
-----------------------------------------------------------
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
F
G
I
S
S
G
A
A
V
W
A
A
R
E
L
A
H
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.07
58%
-96
- C3 -
4AEC
4
CYSKM_ARATH
B:
[111-421]
------------------------------------
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
--
I
--
A
K
--
G
----
C
-------
V
---
A
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
-
F
I
S
P
G-
K
-
S
--
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
T
G
A
V
Q
K
A
E
E
-
I
L
K
N
T
-
P
D
-
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
-
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
-
E
K
N
-
P
K
T
--
Q
V
--
I
G
V
E
P
T
E
S
D
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
R
-
P
E
--
N
A
G
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
S
I
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
83.28
59%
-96
- C3 -
4AEC
3
CYSKM_ARATH
A:
[112-421]
-------------------------------------
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
--
I
--
A
K
--
G
----
C
-------
V
---
A
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
-
F
I
S
P
--
G
K
S
--
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
T
G
A
V
Q
K
A
E
E
-
I
L
K
N
T
-
P
D
-
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
-
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
-
E
K
N
-
P
K
T
--
Q
V
--
I
G
V
E
P
T
E
S
D
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
R
-
P
E
--
N
A
G
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
S
I
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
83.24
56%
-96
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[4-313]
-------------------------------------
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
--
V
--
A
E
--
G
----
C
-------
V
---
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
-
L
I
K
P
--
G
E
S
--
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
K
G
A
I
A
K
A
E
E
-
I
L
A
K
T
-
P
N
-
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
-
E
Q
N
-
A
N
V
--
K
L
--
Y
G
V
E
P
V
E
S
A
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
A
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.12
58%
-95
- C3 -
4AEC
3
CYSKM_ARATH
A:
[111-421]
------------------------------------
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
--
I
--
A
K
--
G
----
C
-------
V
---
A
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
-
F
I
S
P
G-
K
-
S
--
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
T
G
A
V
Q
K
A
E
E
-
I
L
K
N
T
-
P
D
-
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
-
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
-
E
K
N
-
P
K
T
--
Q
V
--
I
G
V
E
P
T
E
S
D
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
R
-
P
E
--
N
A
G
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
S
I
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
83.01
52%
-86
- C3 -
3VC3
1
?
C:
[24-331]
-------------------------------------
N
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
--
V
--
T
E
--
G
----
C
-------
G
---
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
A
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
-
L
I
T
P
G-
K
-
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
--
G
----
M
-
G
G
T
V
K
K
A
Y
E
-
L
L
E
N
T
-
P
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
-
P
N
V
--
K
I
--
Y
G
V
E
P
S
E
S
N
-
V
-----
L
-
N
---
G
-----
G
------
K
P
---
G
------
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
L
-
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
82.99
66%
-85
- C3 -
4LMB
3
?
A:
[8-317]
------------------------------------
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
--
I
--
P
V
--
A
----
E
-------
G
VK-
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
-
L
I
H
P
--
D
K
T
--
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
---
G
S
QG-
M
--
E
-------
G
A
I
T
R
A
E
E
-
I
V
E
N
T
-
P
N
-
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
D
G
-
L
-
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
-
P
R
R
-
P
Q
F
--
Q
A
--
I
A
V
E
P
S
N
S
P
-
V
-----
L
-
S
---
G
-----
G
------
Q
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
R
-
P
E
--
N
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.90
58%
-98
- C3 -
2ISQ
3
CYSK1_ARATH
A:
[3-306]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
--
V
--
A
E
--
G
----
C
-------
V
---
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
-
L
I
K
P
G-
E
-
S
--
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
K
G
A
I
A
K
A
E
E
I
L
A
K
T
P
-
N
G
-
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
-
E
Q
N
-
A
N
V
--
K
L
--
Y
G
V
E
P
V
E
S
A
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.85
99%
-40
- C- -
2Q3C
2
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
--
V
--
T
D
--
G
----
A
-------
V
---
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
-
L
I
K
P
--
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
--
G
----
M
-
S
G
A
I
A
K
A
E
E
-
L
A
K
T
D
-
Q
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
-
E
R
K
-
P
S
A
--
R
F
--
V
A
V
E
P
A
A
S
P
-
V
-----
L
-
S
---
G
-----
G
------
Q
K
---
G
------
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
82.76
52%
-93
- C3 -
3TBH
2
?
A:
[12-318]
---------------------------------------
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
--
L
--
N
N
-------
T
-------
K
---
A
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
-
K
L
I
P
--
G
K
S
--
I
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
--
G
----
M
-
K
G
A
V
A
M
A
K
K
-
I
V
A
A
N
-
P
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
-
N
-
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
-
K
M
G
-
S
H
A
--
R
I
--
V
A
V
E
P
T
E
S
P
-
V
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
R
-
P
E
--
M
E
G
K
T
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
S
V
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.66
57%
-96
- C3 -
1Z7Y
1
CYSK1_ARATH
A:
[5-308]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
--
V
--
A
E
--
G
----
C
-------
V
---
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
-
L
I
K
P
G-
E
-
S
--
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
K
G
A
I
A
K
A
E
E
I
L
A
K
T
P
-
N
G
-
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
-
E
Q
N
-
A
N
V
--
K
L
--
Y
G
V
E
P
V
E
S
A
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
82.51
55%
-95
- C3 -
1OAS
1
CYSK_SALTY
A:
[3-314]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
I
T
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
L
A
GE
E
I
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.49
52%
-93
- C3 -
3VBE
1
?
A:
[24-331]
-------------------------------------
N
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
--
V
--
T
E
--
G
----
C
-------
G
---
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
-
L
I
T
P
G-
K
-
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
--
G
----
M
-
G
G
T
V
K
K
A
Y
E
-
L
L
E
N
T
-
P
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
-
P
N
V
--
K
I
--
Y
G
V
E
P
S
E
S
N
-
V
-----
L
-
N
---
G
-----
G
------
K
P
---
G
------
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
L
-
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.45
55%
-87
- C3 -
1D6S
2
CYSK_SALTY
A:
[3-314]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
I
T
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
L
A
GE
E
I
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.44
58%
-97
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[5-308]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
--
V
--
A
E
--
G
----
C
-------
V
---
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
-
L
I
K
P
G-
E
-
S
--
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
--
G
----
M
-
K
G
A
I
A
K
A
E
E
I
L
A
K
T
P
-
N
G
-
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
-
E
Q
N
-
A
N
V
--
K
L
--
Y
G
V
E
P
V
E
S
A
-
I
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
82.41
50%
-92
- C3 -
3TBH
2
?
A:
[10-318]
-------------------------------------
N
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
--
L
--
N
N
--
T
----
K
-----------
A
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
--
K
-
S
--
I
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
--
G
----
M
-
K
G
A
V
A
M
A
K
K
-
I
V
A
A
N
-
P
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
-
N
-
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
-
K
M
G
-
S
H
A
--
R
I
--
V
A
V
E
P
T
E
S
P
-
V
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
R
-
P
E
--
M
E
G
K
T
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
S
V
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
82.17
55%
-96
- C3 -
1OAS
1
CYSK_SALTY
B:
[3-314]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
IT
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
LAGEEI
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.16
52%
-92
- C3 -
3VBE
1
?
C:
[24-331]
-------------------------------------
N
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
--
V
--
T
E
--
G
----
C
-------
G
---
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
-
L
I
T
P
G-
K
-
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
--
G
----
M
-
G
G
T
V
K
K
A
Y
E
-
L
L
E
N
T
-
P
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
-
P
N
V
--
K
I
--
Y
G
V
E
P
S
E
S
N
-
V
-----
L
-
N
---
G
-----
G
------
K
P
---
G
------
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
L
-
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.08
52%
-91
- C3 -
3VBE
1
?
B:
[24-331]
-------------------------------------
N
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
--
V
--
T
E
--
G
----
C
-------
G
---
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
-
L
I
T
P
G-
K
-
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
--
G
----
M
-
G
G
T
V
K
K
A
Y
E
-
L
L
E
N
T
-
P
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
-
P
N
V
--
K
I
--
Y
G
V
E
P
S
E
S
N
-
V
-----
L
-
N
---
G
-----
G
------
K
P
---
G
------
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
L
-
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.96
55%
-87
- C3 -
1D6S
2
CYSK_SALTY
B:
[3-314]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
IT
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
LAGEEI
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
81.66
57%
-93
- C3 -
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------
S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
-----------------
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
D
L
I
T
--
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
------
L
A
---
G
E
E
I
K
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.55
52%
-91
- C3 -
3VBE
1
?
D:
[24-331]
-------------------------------------
N
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
--
V
--
T
E
--
G
----
C
-------
G
---
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
-
L
I
T
P
G-
K
-
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
--
G
----
M
-
G
G
T
V
K
K
A
Y
E
-
L
L
E
N
T
-
P
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
-
P
N
V
--
K
I
--
Y
G
V
E
P
S
E
S
N
-
V
-----
L
-
N
---
G
-----
G
------
K
P
---
G
------
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
L
-
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
81.35
50%
-94
- C3 -
3T4P
3
?
A:
[10-318]
-------------------------------------
N
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
--
L
--
N
N
--
T
----
K
-----------
A
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
--
K
-
S
--
I
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
--
G
----
M
-
K
G
A
V
A
M
A
K
K
-
I
V
A
A
N
-
P
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
-
N
-
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
-
K
M
G
-
S
H
A
--
R
I
--
V
A
V
E
P
T
E
S
P
-
V
-----
L
-
S
---
G
-----
G
------
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
R
-
P
E
--
M
E
G
K
T
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
S
V
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
81.26
56%
-86
- C3 -
5DBH
2
CYSK_HAEIN
X:
[8-317]
-------------------------------------
A
I
Y
A
D
N
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
--
F
------
G
----
H
-------
N
---
G
N
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
-
T
L
T
K
--
G
-
K
--
E
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
A
K
A
E
E
-
I
V
A
S
D
P
S
R
-
Y
V
M
L
K
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
-
K
Q
I
--
T
S
--
V
A
V
E
P
V
E
S
P
-
V
-----
I
-
S
QTL
A
-----
G
------
E
E
VKP
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
L
-
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
81.22
51%
-92
* C3 *
1VE1
1
?
A:
[2-302]
-----------------------------------------
R
V
E
G
A
I
G
K
T
P
V
V
R
L
A
K
--
V
--
V
E
--
P
----
D
-------
M
---
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
-
I
L
R
P
GS
G
-
Q
--
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
--
R
----
M
-
L
A
A
R
E
E
A
L
R
-
L
K
E
-
E
-
L
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
-
E
R
I
-
P
H
V
--
K
V
--
I
A
V
E
P
A
R
S
N
-
V
-----
L
-
S
---
G
-----
G
------
K
M
---
G
------
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
-
L
G
---
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.13
50%
-98
- C3 -
2PQM
2
?
A:
[13-319]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.97
50%
-100
- C3 -
2PQM
2
?
B:
[13-319]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
80.94
50%
-94
- C3 -
2EFY
2
?
A:
[7-302]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
--
V
--
V
E
--
P
----
D
-------
M
---
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
-
I
L
R
P
--
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
--
R
----
M
-
L
A
A
R
E
E
A
L
R
-
L
-
K
E
E
-
L
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
-
E
R
I
-
P
H
V
--
K
V
--
I
A
V
E
P
A
R
S
N
-
V
-----
L
-
S
---
G
-----
G
------
K
M
---
G
------
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
--
L
--
G
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
80.90
50%
-91
- C3 -
1VE1
1
?
A:
[7-302]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
--
V
--
V
E
--
P
----
D
-------
M
---
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
-
I
L
R
P
--
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
--
R
----
M
-
L
A
A
R
E
E
A
L
R
-
L
-
K
E
E
-
L
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
-
E
R
I
-
P
H
V
--
K
V
--
I
A
V
E
P
A
R
S
N
-
V
-----
L
-
S
---
G
-----
G
------
K
M
---
G
------
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
--
L
--
G
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
80.88
50%
-97
- C3 -
4JBN
2
?
A:
[13-319]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
80.67
55%
-92
- C3 -
1FCJ
4
CYSK_SALTY
B:
[3-304]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
IT
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
LAGEEI
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
80.65
50%
-93
- C3 -
2ECO
2
?
A:
[7-302]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
--
V
--
V
E
--
P
----
D
-------
M
---
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
-
I
L
R
P
--
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
--
R
----
M
-
L
A
A
R
E
E
A
L
R
-
L
-
K
E
E
-
L
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
-
E
R
I
-
P
H
V
--
K
V
--
I
A
V
E
P
A
R
S
N
-
V
-----
L
-
S
---
G
-----
G
------
K
M
---
G
------
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
--
L
--
G
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.63
55%
-94
- C3 -
1FCJ
4
CYSK_SALTY
D:
[3-302]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
IT
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
LAGEEI
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
80.56
50%
-97
- C3 -
2PQM
2
?
A:
[13-322]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
----
P
RIKK---
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
-
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
A
-
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
V
L
-----
E
-
G
---
K
------------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
80.56
50%
-90
- C3 -
2ECQ
2
?
A:
[7-302]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
--
V
--
V
E
--
P
----
D
-------
M
---
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
-
I
L
R
P
--
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
--
R
----
M
-
L
A
A
R
E
E
A
L
R
-
L
-
K
E
E
-
L
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
-
E
R
I
-
P
H
V
--
K
V
--
I
A
V
E
P
A
R
S
N
-
V
-----
L
-
S
---
G
-----
G
------
K
M
---
G
------
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
--
L
--
G
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
80.55
57%
-94
- C3 -
1Y7L
2
CYSK_HAEIN
A:
[2-311]
-------------------------------------
A
I
Y
A
D
N
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
--
F
--
G
H
---------------
N
---
G
N
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
-
T
L
T
K
--
G
-
K
--
E
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
A
K
A
E
E
-
I
V
A
S
D
P
S
R
-
Y
V
M
L
K
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
-
L
D
F
G
K
Q
I
--
T
S
--
V
A
V
E
P
V
E
S
P
-
V
-----
I
S
Q
---
T
L
AG--
E
E
V
----
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
L
-
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
80.35
50%
-89
- C3 -
3BM5
4
?
B:
[12-318]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.33
50%
-98
- C3 -
3BM5
4
?
A:
[12-318]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.13
50%
-96
- C3 -
4IL5
1
?
A:
[13-319]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.99
55%
-91
- C3 -
1FCJ
4
CYSK_SALTY
C:
[3-304]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
IT
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
LAGEEI
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.76
55%
-92
- C3 -
1FCJ
4
CYSK_SALTY
A:
[3-302]
--------------------------------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
--
I
--
G
N
--
G
----
R
-------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
-
V
L
K
P
--
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
--
G
----
M
-
K
G
A
I
Q
K
A
E
E
-
I
V
A
S
D
P
Q
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
-
G
T
K
-
G
K
T
--
D
L
I
T
V
A
V
E
P
T
D
S
P
-
V
-----
I
-
A
---
Q
-----
A
L
A
GEE
I
K
P
---
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
79.71
50%
-89
- C3 -
4JBL
2
?
B:
[13-319]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
--
V
--
T
E
--
H
PRIK
K
-------
G
---
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
-
R
L
K
P
--
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
--
G
----
M
-
P
G
A
I
E
E
V
N
K
-
M
I
K
E
N
P
G
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
-
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
-
E
K
K
-
K
G
I
--
K
I
--
I
A
V
E
P
E
E
S
A
-
V
-----
L
-
E
---
G
-----
K
------
A
K
---
G
------
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
79.10
50%
-91
- C3 -
2EFY
2
?
B:
[7-302]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
--
V
--
V
E
--
P
----
D
-------
M
---
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
-
I
L
R
P
--
G
-
S
GQ
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
--
R
----
M
-
L
A
A
R
E
E
A
L
R
-
L
-
K
E
E
-
L
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
-
E
R
I
-
P
H
V
--
K
V
--
I
A
V
E
P
A
R
S
N
-
V
-----
L
-
S
---
G
-----
G
------
K
M
---
G
------
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
--
L
--
G
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
78.55
47%
-86
- C3 -
3X44
1
DCSD_STRLA
A:
[2-308]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
--
M
--
A
P
--
E
------------
H
---
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
-
L
L
K
P
--
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
--
G
----
S
-
K
G
G
N
L
I
A
D
E
-
L
A
E
-
K
-
Y
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
-
V
A
R
-
P
E
V
--
R
V
--
V
A
L
E
P
S
N
A
A
-
M
-----
L
-
A
---
R
-----
G
------
E
W
---
S
------
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
H
-
A
P
---
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
V
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
78.48
47%
-90
- C3 -
3X44
1
DCSD_STRLA
A:
[2-303]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
--
M
--
A
P
--
E
----
H
-------
T
---
S
-
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
-
L
L
K
P
--
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
--
G
----
S
-
K
G
G
N
L
I
A
D
E
-
L
A
E
K
--
Y
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
-
V
A
R
-
P
E
V
--
R
V
--
V
A
L
E
P
S
N
A
A
-
M
-----
L
-
A
---
R
-----
G
------
E
W
---
S
------
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
H
A
P
E
----
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
78.37
47%
-91
- C3 -
3X44
1
DCSD_STRLA
B:
[2-303]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
--
M
--
A
P
--
E
----
H
-------
T
---
S
-
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
-
L
L
K
P
--
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
--
G
----
S
-
K
G
G
N
L
I
A
D
E
-
L
A
E
K
--
Y
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
-
V
A
R
-
P
E
V
--
R
V
--
V
A
L
E
P
S
N
A
A
-
M
-----
L
-
A
---
R
-----
G
------
E
W
---
S
------
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
H
A
P
E
----
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
76.47
43%
-79
- C3 -
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
AHR
Q
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
--
I
--
P
A
S
D
G
----
I
-------
E
---
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
-
L
L
K
P
--
G
-
Y
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
TEA
A
Y
---
D
--
S
----
P
-
E
G
L
I
Y
V
A
Q
Q
-
L
Q
R
E
T
-
P
N
-
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
-
E
Q
V
-
P
S
C
--
Q
I
--
V
G
V
D
P
Y
G
S
I
-
L
ARPAE
L
-
N
---
K
-----
T
------
D
V
---
Q
------
F
Y
E
V
E
-
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
K
-
L
K
--
K
-
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
NEHGHWWWSLAIAELELPAPP
V
I
L
K
SDAT
V
G
E
A
I
A
L
M
K
K
H
RVD
Q
L
P
V
V
D
QDDGSVL
G
V
V
G
Q
E
T
L
I
T
Q
I
VSMNRQQSDPAIKALNKRV
I
R
L
N
ESEI
L
G
K
L
A
R
V
L
E
V
DP
S
V
L
I
L
G
K
N
PAG
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
GKQK
91
PsiBlast_CBE
76.39
41%
-80
- C3 -
4COO
6
CBS_HUMAN
B:
[98-417]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
K
F
G
----
L
-------
K
---
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
--
S
----
P
-
E
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
-----
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
--
E
-
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
75.92
40%
-81
- C3 -
4L0D
2
CBS_HUMAN
A:
[75-390]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
K
F
G
----
L
-------
K
---
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
--
S
----
P
-
E
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
-----
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
--
E
-
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.58
50%
-101
- C3 -
4AIR
5
?
B:
[31-339]
-------------------------------------
N
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
--
L
--
N
N
-------
T
-------
K
---
A
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
--
K
-
S
--
V
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
--
G
----
M
-
K
G
A
V
T
M
A
K
K
-
I
V
T
A
N
-
P
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
-
N
-
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
-
K
M
G
-
S
H
A
--
R
I
--
V
A
V
E
P
M
E
---------------------------------------------------------
D
R
S
L
I
D
E
V
F
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
R
-
P
E
--
M
E
G
K
T
I
V
T
I
I
P
S
F
G
E
R
Y
L
S
T
A
L
Y
R
S
V
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
75.45
41%
-84
- C3 -
4PCU
2
CBS_HUMAN
B:
[75-392]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
K
F
G
----
L
-------
K
---
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
--
S
----
P
-
S
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
-----
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
--
E
-
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
75.08
41%
-78
- C3 -
4COO
9
CBS_HUMAN
A:
[98-411]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
K
F
G
----
L
-------
K
---
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
--
S
----
P
-
E
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
-----
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
--
E
-
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
75.07
40%
-82
- C3 -
4L0D
2
CBS_HUMAN
B:
[75-389]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
K
F
G
----
L
-------
K
---
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
--
S
----
P
-
E
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
-----
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
--
E
-
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
75.02
42%
-91
- C3 -
2V03
3
CYSM_ECOLI
A:
[2-294]
----------------------------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
--
M
--
G
P
--
D
----
N
-------
G
---
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
-
E
I
K
P
--
G
-
D
--
V
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
--
G
----
M
-
E
G
A
R
D
L
A
L
E
-
M
A
N
R
--
G
E
-
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
-
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
-
E
Q
S
-
K
P
V
--
T
I
--
V
G
L
Q
P
E
E
G
S
-
S
-----
I
-
P
---
G
---------------------------
I
R
-
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
A
A
-
N
----
P
D
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
74.73
41%
-84
- C3 -
4PCU
2
CBS_HUMAN
A:
[75-391]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
K
F
G
----
L
-------
K
---
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
-----ARF
D
--
S
----
P
-
S
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
-----
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
--
E
-
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
74.43
41%
-77
- C3 -
4COO
9
CBS_HUMAN
A:
[99-417]
---------------------------------------
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
--
I
--
G
K
--
K
----
F
-------
G
LK-
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
-
T
L
K
P
--
G
-
D
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
---
A
RF
D
----
S
P
E
S
H
V
G
V
A
W
R
-
L
K
N
E
I
-
P
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
-
E
K
C
-
P
G
C
--
R
I
--
I
G
V
D
P
E
G
S
I
-
L
-----
A
-
E
---
P
EELNQ
T
------
E
Q
---
T
------
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
Q
---
E
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
74.43
39%
-85
- C3 -
3DWG
1
CYSM_MYCTU
A:
[3-313]
------------------------------------
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
--
L
--
S
P
--
R
----
W
DDGRD
G
P
H
---
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
-
L
L
R
P
--
G
-
A
--
T
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
---
A
E
G
G
-
S
--
N
-------
T
A
V
A
T
A
K
E
-
L
A
A
T
N
-
P
S
-
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
P
--
E
-
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
-
E
H
V
-
A
N
V
--
K
I
--
V
A
A
E
P
R
Y
G
E
G
V
-----
Y
--------------------------------
A
L
R
-
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
A
G
-
A
L
A
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
S
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
74.08
42%
-80
- C3 -
3PC3
2
?
A:
[51-366]
---------------------------------------
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
--
I
--
P
A
--
S
----
D
GI-----
E
---
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
-
L
L
K
P
--
G
-
Y
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
AA-
Y
--
D
----
S
P
E
G
L
I
Y
V
A
Q
Q
-
L
Q
R
E
T
-
P
N
-
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
-
E
Q
V
-
P
S
C
--
Q
I
--
V
G
V
D
P
Y
G
S
I
-
L
-----
A
-
R
---
P
A----
E
LNK---
T
D
---
V
------
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
K
-
L
K
---
K
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
71.97
31%
-88
- C3 -
5D84
1
SBNA_STAAE
A:
[8-315]
--------------------------------------
C
H
D
S
L
L
D
S
V
G
Q
T
P
M
V
Q
L
H
Q
--
L
--
F
P
---------------
K
---
H
E
V
F
A
K
L
E
Y
M
N
P
G
G
S
M
K
D
R
P
A
K
Y
I
I
E
H
G
I
K
H
G
-
L
I
T
E
--
N
-
T
--
H
L
I
-
E
S
T
S
G
N
L
G
I
A
L
A
M
I
A
K
I
K
G
L
K
L
T
C
V
V
D
P
K
I
S
P
T
N
L
K
I
I
K
S
Y
G
A
N
V
E
M
V
E
---
E
P
---
D
--
A
HGGY
L
-
M
T
R
I
A
K
V
Q
E
-
L
L
A
T
I
-
D
D
-
A
Y
W
I
N
Q
Y
A
N
E
L
N
W
Q
S
H
-
Y
H
G
A
G
T
E
I
V
E
T
I
K
Q
-
P
-
I
D
Y
F
V
A
P
V
S
T
T
G
S
I
M
G
M
S
R
K
I
K
-
E
V
H
-
P
N
A
--
Q
I
--
V
A
V
D
A
K
G
S
V
-
I
-----
F
-
G
---
D
------------
K
P
---
I
------
N
R
E
L
P
-
G
I
G
A
S
R
V
P
E
I
L
N
R
S
E
I
N
Q
V
I
H
V
D
D
Y
Q
S
A
L
G
C
R
K
L
I
D
Y
E
G
I
F
A
G
G
S
T
G
S
I
I
A
A
I
E
Q
L
I
T
S
-
I
E
---
E
G
A
T
I
V
T
I
L
P
D
R
G
D
R
Y
L
D
L
V
Y
S
D
T
W
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.15
42%
-42
- C3 -
5HBG
1
CYSM_HELPY
B:
[1-305]
------------------------------------
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
N
-----
K
D
--
Y
----
P
-------
I
PLN
S
A
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
-
K
I
T
S
--
K
-
T
--
T
I
I
-
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
---
T
S
---
E
--
G
----
I
-
S
G
A
I
K
K
S
K
E
-
L
A
E
S
I
-
P
D
-
S
Y
L
P
L
Q
F
E
N
P
D
N
P
A
A
Y
-
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
-
N
-
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
-
E
R
I
-
P
A
I
--
R
L
--
I
G
V
E
P
E
G
S
--
I
-----
L
-
N
---
G
-----
G
------
E
P
---
G
------
P
H
E
I
E
-
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
E
A
Q
R
L
P
E
----
G
S
Q
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
52.61
56%
-3
- C3 -
4ZU6
2
CYSK_HAEIN
X:
[17-327]
------------------------------------
M
A
I
Y
A
D
N
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
--
F
------
G
----
H
-------
N
---
G
N
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
-
T
L
T
K
--
G
-
K
--
E
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
--
G
-------
G
A
I
A
K
A
E
E
-
I
V
A
S
D
P
S
R
-
Y
V
M
L
K
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
-
K
Q
I
--
T
S
--
V
A
V
E
P
V
E
S
P
-
V
-----
I
-
S
QTL
A
-----
G
------
E
E
VKP
G
------
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
L
-
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------