@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2361c: (2016-05-10 )
MARDARKRTSSNFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPYGGPCRPPQHTSKAAAPRIPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSRPRLWRSVINELAVAEEMTKSNDVITINYCVNYGGRTEITEATREIAREVAAGRLNPERITESTIARHLQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRTRRFGSA
Atome Classification :
(46 SA)
.........10........20........30........40........50........60........70........80.......-.90-........100.......110.......120.......130.......140.......--150.........160.......170.......180.......190.......200......-.210......----.220....---...230.--.----...----..240.......250.......260.......270.......280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAR
D
A
R
KRTSSNFPQLPPAPDDYPTFPDTSTW
P
V
VFPELPAAPYGGPCRPPQHTSKAAAPRI
P
A
D
RLP
N
H
V
A
I
V
MDGNG
R
W
A
T
QRGLA-RTE-GHKMG
E
A
V
V
I
D
IAC
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
FS
T
E
NWKR
S
P
E
E
V
R
F
L
MGF
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
KL
G
V
R
I
R
W
VGSR
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
MTKSN
D
V
I
T
I
N
Y
C
VNYGGR
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
AAGRL
N
----
P
E
RI
T
E
S
T
---
I
A
R
H
LQR--P----DIP----DV
D
L
F
L
RTSGEQRSS
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
DKLWPDY
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
RFGSA
1
PsiBlast_PDB
99.84
100%
-107
- C- -
2VG2
9
DPDS_MYCTU
A:
[1-284]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
25
PsiBlast_CBE
99.20
100%
-104
- C7 -
2VG2
5
DPDS_MYCTU
D:
[1-284]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
23
PsiBlast_CBE
98.79
100%
-100
- C7 -
2VG3
6
DPDS_MYCTU
C:
[1-284]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
24
PsiBlast_CBE
98.72
100%
-99
- C7 -
2VG3
7
DPDS_MYCTU
B:
[1-284]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
22
PsiBlast_CBE
98.57
100%
-104
- C7 -
2VG3
3
DPDS_MYCTU
D:
[2-284]
-------------
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
80
HHSearch
98.50
100%
-97
- C7 -
2VG3
6
DPDS_MYCTU
A:
[2-284]
-------------
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
27
PsiBlast_CBE
98.49
100%
-99
- C7 -
2VG2
6
DPDS_MYCTU
B:
[1-283]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
-
3
PsiBlast_PDB
98.46
100%
-98
- C7 -
2VG3
6
DPDS_MYCTU
A:
[1-284]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
21
PsiBlast_CBE
98.38
100%
-102
- C7 -
4ONC
2
DPDS_MYCTU
B:
[1-284]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
--
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
26
PsiBlast_CBE
97.90
100%
-99
- C7 -
2VG2
8
DPDS_MYCTU
C:
[2-284]
-------------
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
4
PsiBlast_PDB
97.71
100%
-104
- C7 -
4ONC
1
DPDS_MYCTU
A:
[1-280]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
---
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
----
2
PsiBlast_PDB
97.61
100%
-96
- C7 -
2VG4
-
DPDS_MYCTU
A:
[13-296]
------------
F
P
Q
L
P
P
A
P
D
D
Y
P
T
F
P
D
T
S
T
W
P
V
V
F
P
E
L
P
A
A
P
Y
G
G
P
C
R
P
P
Q
H
T
S
K
A
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
-
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
--
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
-
A
R
E
V
A
A
G
R
L
N
----
P
E
R
I
T
E
S
T
---
I
A
R
H
L
Q
R
--
P
----
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
56
PsiBlast_CBE
73.94
42%
-93
- C7 -
1UEH
9
UPPS_ECOLI
B:
[20-241]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
-----
13
PsiBlast_PDB
73.80
42%
-91
- C7 -
1V7U
2
UPPS_ECOLI
A:
[20-239]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
59
PsiBlast_CBE
73.09
38%
-95
- C7 -
5HC8
5
?
A:
[13-243]
-------------------------------------------------------------------
P
N
H
V
A
I
I
I
D
G
H
R
K
W
A
K
S
R
G
V
T
-
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
--
L
V
T
S
Q
Q
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
-
A
A
K
V
E
H
G
I
L
R
----
P
D
D
I
D
E
A
T
---
F
E
Q
H
L
M
T
NI
T
----
K
F
P
----
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
Y
R
G
F
G
--
57
PsiBlast_CBE
72.75
41%
-89
- C7 -
1X09
3
UPPS_ECOLI
A:
[20-239]
---------------------------------------------------------------------
H
V
A
I
I
M
A
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
60
PsiBlast_CBE
72.74
38%
-94
- C7 -
5HC7
3
?
A:
[13-238]
-------------------------------------------------------------------
P
N
H
V
A
I
I
I
D
G
H
R
K
W
A
K
S
R
G
V
T
-
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
--
L
V
T
S
Q
Q
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
-
A
A
K
V
E
H
G
I
L
R
----
P
D
D
I
D
E
A
T
---
F
E
Q
H
L
M
T
NI
T
----
K
F
P
----
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
-------
61
PsiBlast_CBE
72.69
38%
-96
- C7 -
5HC6
3
?
A:
[13-238]
-------------------------------------------------------------------
P
N
H
V
A
I
I
I
D
G
H
R
K
W
A
K
S
R
G
V
T
-
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
--
L
V
T
S
Q
Q
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
-
A
A
K
V
E
H
G
I
L
R
----
P
D
D
I
D
E
A
T
---
F
E
Q
H
L
M
T
NI
T
----
K
F
P
----
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
-------
58
PsiBlast_CBE
72.43
41%
-89
- C7 -
1X08
3
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
A
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
82
HHSearch
72.42
38%
-92
- C7 -
5HC8
5
?
A:
[9-244]
---------------------------------------------------------------
D
E
V
T
P
N
H
V
A
I
I
I
D
G
H
R
K
W
A
K
S
R
G
V
T
-
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
L
V
T
--
S
Q
Q
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
-
A
A
K
V
E
H
G
I
L
R
----
P
D
D
I
D
E
A
T
---
F
E
Q
H
L
M
T
--
N
IT--
K
F
P
----
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
Y
R
G
F
G
E
-
14
PsiBlast_PDB
72.41
42%
-89
- C7 -
1X06
4
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
48
PsiBlast_CBE
72.26
42%
-91
- C7 -
3SGV
3
UPPS_ECOLI
A:
[20-238]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
--------
15
PsiBlast_PDB
72.22
42%
-89
- C7 -
1X07
3
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
47
PsiBlast_CBE
71.84
42%
-98
- C7 -
3SGV
2
UPPS_ECOLI
B:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-----------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
8
PsiBlast_PDB
71.80
41%
-94
- C7 -
4Q9M
12
ISPT_STRR6
A:
[11-240]
---------------------------------------------------------------
T
-
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
-
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
--
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
-
S
Q
D
V
L
D
A
K
I
N
----
P
G
D
I
T
E
E
L
---
I
G
N
Y
L
F
T
--
Q
----
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------
17
PsiBlast_PDB
71.76
42%
-84
- C7 -
2E99
3
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
79
HHSearch
71.71
41%
-94
* C7 *
3SGV
2
UPPS_ECOLI
B:
[14-240]
---------------------------------------------------------------
P
A
H
G
C
R
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-----------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
29
PsiBlast_CBE
71.66
41%
-93
- C7 -
4Q9M
8
ISPT_STRR6
B:
[12-239]
-----------------------------------------------------------------
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
-
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
--
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
-
S
Q
D
V
L
D
A
K
I
N
----
P
G
D
I
T
E
E
L
---
I
G
N
Y
L
F
T
--
Q
----
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
-------
81
HHSearch
71.52
39%
-95
- C7 -
4H8E
3
ISPT_STAAN
A:
[19-253]
-------------------------------------------------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
D
G
N
G
R
W
A
K
K
R
K
M
P
-
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
--
L
--
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
-
F
D
E
L
H
Q
Q
G
L
N
----
S
D
I
I
D
E
T
Y
---
I
N
N
H
L
M
T
--
K
----
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
6
PsiBlast_PDB
71.30
38%
-96
- C7 -
4U82
3
ISPT_STAAN
A:
[19-251]
-------------------------------------------------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
D
G
N
G
R
W
A
K
K
R
K
M
P
-
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
--
L
--
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
-
F
D
E
L
H
Q
Q
G
L
N
----
S
D
I
I
D
E
T
Y
---
I
N
N
H
L
M
T
--
K
----
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
--
83
HHSearch
71.02
42%
-92
- C7 -
4Q9M
12
ISPT_STRR6
A:
[11-240]
----------------------------------------------------------------
T
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
-
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
--
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
-
S
Q
D
V
L
D
A
K
I
N
----
P
G
D
I
T
E
E
L
---
I
G
N
Y
L
F
T
--
Q
HLPK
D
L
R
----
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------
5
PsiBlast_PDB
70.81
38%
-95
- C7 -
4H8E
3
ISPT_STAAN
A:
[19-251]
-------------------------------------------------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
D
G
N
G
R
W
A
K
K
R
K
M
P
-
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
--
L
--
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
-
F
D
E
L
H
Q
Q
G
L
N
----
S
D
I
I
D
E
T
Y
---
I
N
N
H
L
M
T
--
K
----
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
--
16
PsiBlast_PDB
70.37
42%
-84
- C7 -
2E98
4
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
54
PsiBlast_CBE
70.22
42%
-94
- C7 -
2E98
3
UPPS_ECOLI
B:
[20-243]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---
20
PsiBlast_PDB
70.17
42%
-94
- C7 -
2E9D
2
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
53
PsiBlast_CBE
70.15
42%
-95
- C7 -
2E99
2
UPPS_ECOLI
B:
[20-243]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---
18
PsiBlast_PDB
70.03
42%
-90
- C7 -
2E9A
2
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
---------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
52
PsiBlast_CBE
69.69
42%
-95
- C7 -
2E9A
1
UPPS_ECOLI
B:
[20-242]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
------------
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
----
19
PsiBlast_PDB
69.59
42%
-96
- C7 -
2E9C
3
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
-------------------
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
42
PsiBlast_CBE
69.52
42%
-97
- C7 -
3WYJ
1
UPPS_ECOLI
A:
[20-240]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
-----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
51
PsiBlast_CBE
68.74
42%
-93
- C7 -
2E9C
1
UPPS_ECOLI
B:
[20-239]
---------------------------------------------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
-
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
--
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
-
A
E
K
V
Q
Q
G
N
L
Q
----
P
D
Q
I
D
E
E
M
---
L
N
Q
H
V
C
M
--
H
----
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
87
HHSearch
67.32
35%
-86
- C7 -
2VG0
2
ZFPP_MYCTU
A:
[1-227]
-----------------------------------------------------------------
D
L
P
R
H
I
A
V
L
C
D
G
N
R
R
W
A
R
S
A
G
Y
D
D
V
S
Y
-
G
Y
R
M
G
A
A
K
I
A
E
M
L
R
W
C
H
E
A
G
I
E
L
A
T
V
Y
L
L
S
T
E
N
L
Q
R
D
P
D
E
L
A
A
L
I
E
I
I
T
D
V
V
E
E
I
C
----
A
--
P
A
N
H
W
S
V
R
T
V
G
D
L
G
L
I
G
E
E
P
A
R
R
L
R
G
A
V
E
S
T
P
E
V
A
S
F
H
V
N
V
A
V
G
Y
G
G
R
R
E
I
V
D
A
V
R
A
L
-
L
S
K
E
L
A
N
G
A
T
A
E
E
L
V
D
A
V
T
V
E
G
---
I
S
E
N
L
Y
T
--
S
----
G
Q
P
----
D
P
D
L
V
I
R
T
S
G
E
Q
R
L
S
G
F
L
L
W
Q
S
A
Y
S
E
M
W
F
T
E
A
H
W
P
A
F
R
H
V
D
F
L
R
A
L
R
D
Y
S
A
R
-------
62
PsiBlast_CBE
66.07
36%
-88
- C7 -
2DTN
1
ISPT_HELPY
B:
[15-241]
------------------------------------------------------------------
T
L
K
H
L
A
I
I
M
D
G
N
G
R
W
A
K
L
K
N
K
A
-
R
A
Y
-
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
----------------
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
--
Y
--
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
-
L
-
E
S
P
-------------
L
E
N
E
---
I
S
N
R
L
D
T
--
R
----
N
L
P
----
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
K
F
G
--
65
PsiBlast_CBE
65.35
35%
-79
- C7 -
2VG1
6
ZFPP_MYCTU
B:
[3-228]
------------------------------------------------------------------
L
P
R
H
I
A
V
L
C
D
G
N
R
R
W
A
R
S
A
G
Y
D
-
D
V
S
Y
G
Y
R
M
G
A
A
K
I
A
E
M
L
R
W
C
H
E
A
G
I
E
L
A
T
V
Y
L
L
S
T
E
N
L
Q
R
D
P
D
E
L
A
A
L
I
E
I
I
T
D
V
V
E
E
I
C
A
P
--
A
--
N
H
W
S
V
R
T
--
V
G
D
L
G
L
I
G
E
E
P
A
R
R
L
R
G
A
V
E
S
T
P
E
V
A
S
F
H
V
N
V
A
V
G
Y
G
G
R
R
E
I
V
D
A
V
R
A
L
L
S
K
E
L
A
N
G
A
T
A
----
E
E
L
V
D
A
V
T
VEG
I
S
E
N
L
Y
T
--
S
----
G
Q
P
----
D
P
D
L
V
I
R
T
S
G
E
Q
R
L
S
G
F
L
L
W
Q
S
A
Y
S
E
M
W
F
T
E
A
H
W
P
A
F
R
H
V
D
F
L
R
A
L
R
D
Y
S
A
R
-------
68
PsiBlast_CBE
65.34
35%
-77
- C7 -
2VG0
2
ZFPP_MYCTU
A:
[2-227]
------------------------------------------------------------------
L
P
R
H
I
A
V
L
C
D
G
N
R
R
W
A
R
S
A
G
Y
D
-
D
V
S
Y
G
Y
R
M
G
A
A
K
I
A
E
M
L
R
W
C
H
E
A
G
I
E
L
A
T
V
Y
L
L
S
T
E
N
L
Q
R
D
P
D
E
L
A
A
L
I
E
I
I
T
D
V
V
E
E
I
C
A
P
--
A
--
N
H
W
S
V
R
T
--
V
G
D
L
G
L
I
G
E
E
P
A
R
R
L
R
G
A
V
E
S
T
P
E
V
A
S
F
H
V
N
V
A
V
G
Y
G
G
R
R
E
I
V
D
A
V
R
A
L
L
S
K
E
L
A
N
G
A
T
A
----
E
E
L
V
D
A
V
T
V
E
G
I
S
E
N
L
Y
T
--
S
----
G
Q
P
----
D
P
D
L
V
I
R
T
S
G
E
Q
R
L
S
G
F
L
L
W
Q
S
A
Y
S
E
M
W
F
T
E
A
H
W
P
A
F
R
H
V
D
F
L
R
A
L
R
D
Y
S
A
R
-------
67
PsiBlast_CBE
64.36
35%
-78
- C7 -
2VG0
3
ZFPP_MYCTU
B:
[2-227]
------------------------------------------------------------------
L
P
R
H
I
A
V
L
C
D
G
N
R
R
W
A
R
S
A
G
Y
D
-
D
V
S
Y
G
Y
R
M
G
A
A
K
I
A
E
M
L
R
W
C
H
E
A
G
I
E
L
A
T
V
Y
L
L
S
T
E
N
L
Q
R
D
P
D
E
L
A
A
L
I
E
I
I
T
D
V
V
E
E
I
C
A
P
--
A
--
N
H
W
S
V
R
T
--
V
G
D
L
G
L
I
G
E
E
P
A
R
R
L
R
G
A
V
E
S
T
P
E
V
A
S
F
H
V
N
V
A
V
G
Y
G
G
R
R
E
I
V
D
A
V
R
A
L
L
S
K
E
L
A
N
G
A
T
A
----
E
E
L
V
D
A
V
T
VEG
I
S
E
N
L
Y
T
--
S
----
G
Q
P
----
D
P
D
L
V
I
R
T
S
G
E
Q
R
L
S
G
F
L
L
W
Q
S
A
Y
S
E
M
W
F
T
E
A
H
W
P
A
F
R
H
V
D
F
L
R
A
L
R
D
Y
S
A
R
-------