@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2386c: (2016-05-10 )
MSELSVATGAVSTASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100--.........110.......120.......130.......140.......150........160.......170.......180.......190.......200.......210.....--..220.......230.......240.------......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSELSVATGAVSTASSSIPMPAGV
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
SVDE
D
Y
L
L
Y
ECDG
Q
W
V
L
A
A
G
V
Q
A
M
V
ELDS
D
E
L
R
V
I
R
DGV
T
R
R
Q
QWSGRPG
A
A
L
G
E
A
V
D
R
L
L
----
L
ETDQA
F
G
W
V
A
F
EF
G
V
H
R
Y
G
L
Q
Q
RLAPHT
P
L
A
R
VFSPR
T
R
I
M
V
SEK
E
I
R
L
F
-
D
AGI
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
EVPQSRSVDVSDD
P
S
G
F
R
R
R
V
A
V
A
V
D
E
IAAG
R
Y
H
K
V
I
L
S
R
CVEV
P
F
A
--IDFP
L
T
Y
RLGRRHNT
P
V
R
S
F
L
L
Q
LGG------
I
R
ALGYSPE
L
V
T
A
VRAD
G
V
V
I
TEPLAGTRALGRGP
A
I
D
R
L
A
R
D
DLES
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
IAEPGS
A
A
V
I
D
F
M
T
VRERG
S
V
Q
H
L
G
S
T
I
R
ARLDPS
S
D
R
M
A
A
L
E
A
L
F
P
A
V
TASGIPK
A
A
G
V
E
A
I
F
R
L
D
ECPRGLYS
G
A
V
V
M
L
SADGGL
D
A
A
L
T
L
R
A
A
Y
QVG
G
R
T
W
L
R
AGAGIIEES
E
P
E
R
E
F
E
E
T
C
E
K
L
S
TLT
P
Y
LVARQ
4
PsiBlast_PDB
96.57
99%
-103
- C1 -
2G5F
3
MBTI_MYCTU
A:
[15-449]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
32
PsiBlast_CBE
96.40
99%
-102
- C1 -
2G5F
4
MBTI_MYCTU
C:
[15-449]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
21
PsiBlast_CBE
96.27
100%
-103
- C1 -
3ST6
1
MBTI_MYCTU
B:
[15-449]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
31
PsiBlast_CBE
96.24
99%
-103
- C1 -
2G5F
3
MBTI_MYCTU
D:
[15-449]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
36
PsiBlast_CBE
96.11
100%
-102
- C1 -
3VEH
4
MBTI_MYCTU
B:
[3-451]
M
S
E
L
S
V
A
T
G
A
V
S
T
A
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
35
PsiBlast_CBE
95.43
100%
-104
- C1 -
3VEH
6
MBTI_MYCTU
C:
[17-451]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
28
PsiBlast_CBE
95.33
99%
-107
- C1 -
3RV7
1
MBTI_MYCTU
C:
[15-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
-----
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
Q
8
PsiBlast_PDB
95.21
100%
-104
- C1 -
3LOG
3
MBTI_MYCTU
A:
[17-451]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
24
PsiBlast_CBE
95.17
100%
-103
- C1 -
3RV8
1
MBTI_MYCTU
B:
[15-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
----
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
Q
33
PsiBlast_CBE
95.13
99%
-104
- C1 -
2G5F
3
MBTI_MYCTU
B:
[17-449]
----------------
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
--
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
-
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
23
PsiBlast_CBE
95.08
100%
-108
- C1 -
3RV8
1
MBTI_MYCTU
C:
[15-449]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
-----
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
7
PsiBlast_PDB
95.03
99%
-113
- C1 -
3RV9
1
MBTI_MYCTU
A:
[15-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
-----------
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
-----
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
Q
53
HHSearch
94.97
100%
-104
- C1 -
3LOG
3
MBTI_MYCTU
A:
[17-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
--
34
PsiBlast_CBE
94.69
100%
-104
- C1 -
3VEH
3
MBTI_MYCTU
D:
[12-451]
---------
A
V
S
T
A
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
-
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
2
PsiBlast_PDB
94.63
100%
-103
- C1 -
3ST6
1
MBTI_MYCTU
A:
[15-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
Q
30
PsiBlast_CBE
94.62
99%
-110
- C1 -
3RV6
4
MBTI_MYCTU
B:
[15-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
-------------------
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
----
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
Q
25
PsiBlast_CBE
94.31
99%
-109
- C1 -
3RV9
1
MBTI_MYCTU
D:
[14-449]
-------------
A
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
-------
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
----
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
9
PsiBlast_PDB
94.31
100%
-101
- C1 -
3VEH
4
MBTI_MYCTU
A:
[17-451]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
38
PsiBlast_CBE
94.29
100%
-101
- C1 -
3LOG
3
MBTI_MYCTU
C:
[17-451]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
A
I
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
6
PsiBlast_PDB
93.98
99%
-110
- C1 -
3RV7
1
MBTI_MYCTU
A:
[15-449]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
-------------
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
------
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
-
5
PsiBlast_PDB
93.28
99%
-108
- C1 -
3RV6
5
MBTI_MYCTU
A:
[15-450]
--------------
S
S
S
I
P
M
P
A
G
V
N
P
A
D
L
A
A
E
L
A
A
V
V
T
E
S
V
D
E
D
Y
L
L
Y
E
C
D
G
Q
W
V
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
----
L
E
T
D
Q
A
F
G
W
V
A
F
E
F
G
V
H
R
Y
G
L
Q
Q
R
L
A
P
H
T
P
L
A
R
V
F
S
P
R
T
R
I
M
V
S
E
K
E
I
R
L
F
-
D
A
G
I
R
H
R
E
A
I
D
R
L
L
A
T
G
V
R
E
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
G
------
I
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
G
V
V
I
T
E
P
L
A
G
T
R
A
------------
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
-------
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
R
Q
11
PsiBlast_PDB
66.01
37%
-86
- C1 -
2FN1
3
?
A:
[23-436]
--------------------------------
I
S
G
V
L
R
Q
F
A
E
E
E
C
Y
V
Y
E
R
P
P
C
W
Y
L
G
K
G
C
Q
A
R
L
H
I
N
A
D
G
T
Q
A
T
F
I
D
D
A
G
E
Q
K
W
A
V
D
---
S
I
A
D
C
A
R
R
F
M
A
HPQ
V
K
G
R
R
V
Y
G
Q
V
G
F
N
F
A
A
H
A
R
G
I
A
F
N
-
A
G
E
W
P
L
L
T
L
T
V
P
R
E
E
L
I
F
E
K
G
N
V
T
V
Y
A
D
-------------------
A
P
--
L
A
V
D
T
A
L
N
G
E
A
Y
K
Q
Q
V
A
R
A
V
A
E
I
R
R
G
E
Y
V
K
V
I
V
S
R
A
I
P
L
P
S
R
--
I
D
M
P
A
T
L
L
Y
G
R
Q
A
N
T
P
V
R
S
F
M
F
R
Q
E
G
------
R
E
A
L
G
F
S
P
E
L
V
M
S
V
T
G
N
K
V
V
-
T
E
P
L
A
G
T
R
D
R
M
G
N
P
E
H
N
K
A
K
E
A
E
L
L
H
D
S
K
E
V
L
E
H
I
L
S
V
K
E
A
I
A
E
L
E
A
V
C
L
P
G
S
V
V
V
E
D
L
M
S
V
R
Q
R
G
S
V
Q
H
L
G
S
G
V
S
G
Q
L
A
E
N
K
D
A
W
D
A
F
T
V
L
F
P
S
I
T
A
S
G
I
P
K
N
A
A
L
N
A
I
M
Q
I
E
K
T
P
R
E
L
Y
S
G
A
I
L
L
L
D
-
D
T
R
F
D
A
A
L
V
L
R
S
V
F
Q
D
S
Q
R
C
W
I
Q
A
G
A
G
I
I
A
Q
S
T
P
E
R
E
L
T
E
T
R
E
K
L
A
S
I
A
P
Y
L
M
---
40
PsiBlast_CBE
65.94
37%
-83
- C1 -
2FN1
3
?
B:
[23-436]
--------------------------------
I
S
G
V
L
R
Q
F
A
E
E
E
C
Y
V
Y
E
R
P
P
C
W
Y
L
G
K
G
C
Q
A
R
L
H
I
N
A
D
G
T
Q
A
T
F
I
D
D
A
G
E
Q
K
W
A
V
D
---
S
I
A
D
C
A
R
R
F
M
A
HPQ
V
K
G
R
R
V
Y
G
Q
V
G
F
N
F
A
A
H
A
R
G
I
A
F
N
-
A
G
E
W
P
L
L
T
L
T
V
P
R
E
E
L
I
F
E
K
G
N
V
T
V
Y
A
D
--------------------
P
--
L
A
V
D
T
A
L
N
G
E
A
Y
K
Q
Q
V
A
R
A
V
A
E
I
R
R
G
E
Y
V
K
V
I
V
S
R
A
I
P
L
P
S
R
--
I
D
M
P
A
T
L
L
Y
G
R
Q
A
N
T
P
V
R
S
F
M
F
R
Q
E
G
------
R
E
A
L
G
F
S
P
E
L
V
M
S
V
T
G
N
K
V
V
-
T
E
P
L
A
G
T
R
D
R
M
G
N
P
E
H
N
K
A
K
E
A
E
L
L
H
D
S
K
E
V
L
E
H
I
L
S
V
K
E
A
I
A
E
L
E
A
V
C
L
P
G
S
V
V
V
E
D
L
M
S
V
R
Q
R
G
S
V
Q
H
L
G
S
G
V
S
G
Q
L
A
E
N
K
D
A
W
D
A
F
T
V
L
F
P
S
I
T
A
S
G
I
P
K
N
A
A
L
N
A
I
M
Q
I
E
K
T
P
R
E
L
Y
S
G
A
I
L
L
L
D
-
D
T
R
F
D
A
A
L
V
L
R
S
V
F
Q
D
S
Q
R
C
W
I
Q
A
G
A
G
I
I
A
Q
S
T
P
E
R
E
L
T
E
T
R
E
K
L
A
S
I
A
P
Y
L
M
---
13
PsiBlast_PDB
41.08
32%
-55
- C1 -
5CWA
5
TRPE_MYCTO
A:
[246-494]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Q
I
A
A
G
E
A
F
Q
V
V
P
S
Q
R
F
E
M
D
T
D
--
V
D
P
I
D
V
Y
R
I
L
R
V
T
N
P
S
P
Y
M
Y
L
L
Q
V
P
N
SDGAVD
F
S
I
V
G
S
S
P
E
A
L
V
T
V
H
-
E
G
W
A
T
T
H
P
I
A
G
T
R
W
R
G
R
T
D
D
E
D
V
L
L
E
K
E
L
L
A
D
D
K
E
R
A
E
H
L
M
L
V
D
L
G
R
N
D
L
G
R
V
C
T
P
G
T
V
R
V
E
D
Y
S
H
I
E
R
Y
S
H
V
M
H
L
V
S
T
V
T
G
K
L
G
E
G
R
T
A
L
D
A
V
T
A
C
F
P
A
G
T
L
S
G
A
P
K
V
R
A
M
E
L
I
E
E
V
E
K
T
R
R
G
L
Y
G
G
V
V
G
Y
L
D
F
A
G
N
A
D
F
A
I
A
I
R
T
A
L
M
R
N
G
T
A
Y
V
Q
A
G
G
G
V
V
A
D
S
N
G
S
Y
E
Y
N
E
A
R
N
K
------------
14
PsiBlast_PDB
38.76
32%
-61
- C1 -
4GRH
4
?
A:
[189-449]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
Q
R
F
T
D
G
V
R
R
V
I
E
Y
L
R
A
G
D
V
F
Q
V
N
L
S
R
R
W
N
A
Q
F
A
AP
V
S
P
Q
A
L
Y
A
Q
L
R
R
A
N
P
A
P
F
A
G
L
F
S
A
H
G
------
R
H
V
V
S
S
S
P
E
R
L
V
S
V
H
A
-
G
H
A
Q
T
R
P
I
A
G
T
R
P
R
F
E
G
D
--
D
------------
E
R
A
E
H
V
M
L
I
D
L
E
R
N
D
L
G
R
I
C
L
P
G
T
V
V
V
D
E
L
M
T
V
E
S
Y
A
H
V
H
H
I
V
S
N
V
S
G
H
L
R
P
E
V
T
P
G
E
V
I
A
A
T
F
P
G
G
T
I
T
G
C
P
K
V
R
C
M
Q
I
I
S
E
L
E
Q
V
P
R
G
A
Y
T
G
A
F
G
W
L
N
R
D
G
D
L
D
L
N
I
L
I
R
T
A
E
V
D
G
H
E
V
S
F
R
T
G
A
G
I
V
V
D
S
D
P
D
K
E
L
D
E
T
R
A
K
A
R
G
L
--------