@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2397c: (2016-05-10 )
MTYAIVVADATKRYGDFVALDHVDFVVPTGSLTALLGPSGSGKSTLLRTIAGLDQPDTGTITINGRDVTRVPPQRRGIGFVFQHYAAFKHLTVRDNVAFGLKIRKRPKAEIKAKVDNLLQVVGLSGFQSRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGSPTDVYDAPANAFVMSFLGAVSTLNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVLGFEVRVELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGGVSGVDDAGVERVKVTST
Atome Classification :
(46 SA)
.........10...--.-.--..--.20........30........40........50........60....--------...----.-----70----...--.---------------.....80...--.....90........100....--....110.......120....-...130---..-----------......140.......150.......160.......170.......180.......190.......200---.......210.......220.......230...-...--.240.-----------------------------------.--------------------------------------.....250--....--------------------.....260.......270.......280.......290.......300.......310....-...320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
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Y
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ADATKRY--G-
D
--
F
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--
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F
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VPTG
S
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T
A
L
LGPSGS
G
K
S
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L
L
R
T
I
AGLDQPD
T
G
T
I
T
ING--------RDV----T-----R-----VPP--Q---------------RR
G
I
G
F
V
F
Q
H
--
Y
A
A
FK
H
L
T
VRDN
V
A
F
G
-
L
K
IRK--R
P
K
A
E
I
K
A
K
V
D
N
L
L
Q
V
VGLS
G
-
F
Q
SRY----PN-----------QLSG
G
Q
R
Q
R
M
A
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A
LAVDP
E
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LDEPF
G
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HDEV
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THDQ
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D
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A
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HKG
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EQVGSPTDVYDA
P
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M
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F
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-
G
A
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--
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TLNG-----------------------------------S--------------------------------------LVRPHD----IRVG--------------------RTP
N
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AADGTAG
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TSAATG
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Q
ITRGDAE
A
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A
LR-EG
D
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Y
V
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A
TRVPPIAGGVSGVDDAG
V
E
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K
VTST
113
HHSearch
89.18
43%
-117
- C1 -
2IT1
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A:
[2-345]
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VEDGKLVITEK
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IPKQY
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GIT
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-
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----------------------
115
HHSearch
88.24
44%
-115
- C1 -
1Z47
1
?
A:
[12-348]
-
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-----------------------------------
A
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DPAVSEG
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T
-------------------------
110
HHSearch
87.76
38%
-117
- C1 -
4TQU
-
?
S:
[1-351]
M
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RIAVDSTQHVELNGGNRISLLPRAGTHLAPGQEVV
F
--------------------------------------
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112
HHSearch
85.27
41%
-120
- C1 -
1V43
-
?
A:
[10-360]
-
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QMDLLKDYVG
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116
HHSearch
84.59
39%
-117
- C1 -
2YYZ
3
?
A:
[2-346]
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111
HHSearch
84.33
36%
-110
- C1 -
3D31
2
?
A:
[1-343]
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V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
C
G
V
---
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
-
P
G
V
Q
I
Y
A
R
F
K
A
S
S
----------------------
102
Fugue
84.23
39%
-89
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P-
G
-
G
--
A
R
--
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
--------
K
R
V
----
T
-----
D
-----
L
P
P
--
Q
---------------
K
R
N
V
G
L
V
F
Q
N
--
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
--
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
----
P
H
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
---
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
-
G
E
S
--
N
V
W
T
R
-----------------------------------
A
--------------------------------------
V
Q
N
G
R
I
----
E
V
A
G
--------------------
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
--------
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
119
HHSearch
83.78
36%
-101
- C1 -
1OXX
25
?
K:
[2-346]
--
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
GK
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
-----
S
NGKLI
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
KVTNEGVVIGSLRFPVSVSSDRAI-----------
I
--------------------------------------
G
I
R
P
E
D
----
V
K
L
S
--------------------
K
D
V
I
K
-------
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
-
S
-
E
E
E
I
F
----
T
Y
S
D
H
P
I
H
-
S
G
E
E
V
L
V
Y
V
R
K
D
K
----------------------
118
HHSearch
81.95
36%
-111
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-351]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
--------
K
R
M
----
N
-----
D
-----
T
P
P
--
A
---------------
E
R
G
V
G
M
V
F
Q
S
--
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
--
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
----
P
K
-----------
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
---
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
S
P
K
M
N
F
L
P
V
-----------------------------------
K
V
TATAID
Q
V
Q
V
E
L
PMPNR
Q
Q
V
W
L
PVESRDVQVG
A
N
M
S
L
G
I
R
P
E
H
----
L
L
P
S
---------------------------------
D
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
----
Q
N
D
V
V
L
V
E
-
E
G
A
T
F
A
I
G
L
P
P
E
R
----------------------
101
Fugue
81.52
33%
-98
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
SNGKL
I
-----
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
-----------------------------------
K
--------------------------------------
V
T
N
E
-
G
----
V
V
I
G
-------------------------
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
2
PsiBlast_PDB
77.23
52%
-117
- C1 -
2IT1
-
?
A:
[4-235]
----
I
K
L
E
N
I
V
K
K
F
--
G
-
N
--
F
T
--
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
--------
K
D
V
----
T
-----
E
-----
L
P
P
--
K
---------------
D
R
N
V
G
L
V
F
Q
N
--
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
--
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
-
L
L
N
R
Y
----
P
W
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
---
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
77.10
34%
-101
- C1 -
3D31
2
?
B:
[2-338]
----
I
E
I
E
S
L
S
R
K
W
--
K
-
N
--
F
---
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
--------
K
D
V
----
T
-----
D
-----
L
S
P
--
E
---------------
K
H
D
I
A
F
V
Y
Q
N
--
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
-
M
R
M
K
K
IK
D
P
K
R
V
L
D
T
A
R
D
-----
L
K
I
E
H
-
L
L
D
R
N
----
P
L
-----------
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
---
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
-
G
F
E
--
N
V
L
K
G
-----------------------------------
R
--------------------------------------
V
I
S
A
E
Q
GLLR
I
R
V
G
EVVIDAAGDMEVGDQVYAFL
R
P
E
N
I
A
L
S
K
S
S
T
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
---
C
G
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
-
P
G
V
Q
I
Y
A
R
---------------------------
51
PsiBlast_CBE
77.00
34%
-102
- C1 -
3D31
2
?
A:
[2-338]
----
I
E
I
E
S
L
S
R
K
W
--
K
-
N
--
F
---
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
--------
K
D
V
----
T
-----
D
-----
L
S
P
--
E
---------------
K
H
D
I
A
F
V
Y
Q
N
--
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
-
M
R
M
K
K
IK
D
P
K
R
V
L
D
T
A
R
D
-----
L
K
I
E
H
-
L
L
D
R
N
----
P
L
-----------
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
---
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
-
G
F
E
--
N
V
L
K
G
-----------------------------------
R
--------------------------------------
V
I
S
A
E
Q
G
L
L
R
I
R
V
G
E
V
V
I
D
A
A
G
DMEVGDQ
V
Y
A
F
L
R
P
E
N
I
A
L
S
K
S
S
T
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
---
C
G
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
-
P
G
V
Q
I
Y
A
R
---------------------------
26
PsiBlast_CBE
76.79
42%
-110
- C1 -
1OXU
7
?
B:
[4-251]
----
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
-----
S
NGKLI
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
-----------------------------------
K
--------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.45
52%
-118
- C1 -
2IT1
1
?
B:
[4-235]
----
I
K
L
E
N
I
V
K
K
F
--
G
-
N
--
F
T
--
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
--------
K
D
V
----
T
-----
E
-----
L
P
P
--
K
---------------
D
R
N
V
G
L
V
F
Q
N
--
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
--
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
-
L
L
N
R
Y
----
P
W
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
---
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.32
42%
-108
- C1 -
1OXS
20
?
C:
[4-251]
----
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
-----
S
NGKLI
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
-----------------------------------
K
--------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.20
42%
-108
- C1 -
1OXV
7
?
A:
[4-251]
----
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
-----
S
NGKLI
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
-----------------------------------
K
--------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.68
44%
-114
- C1 -
4XIG
-
?
S:
[1-237]
M
V
A
S
V
S
I
Q
N
V
V
K
R
Y
--
D
-
K
--
T
T
--
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
--------
R
V
I
----
N
-----
D
-----
L
A
P
--
K
---------------
D
R
D
V
A
M
V
F
Q
N
--
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
R
--
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
----
P
S
-----------
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
---
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
-
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.56
42%
-108
- C1 -
1OXU
7
?
A:
[4-251]
----
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
-----
S
NGKLI
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
-----------------------------------
K
--------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.53
42%
-109
- C1 -
1OXU
13
?
C:
[4-251]
----
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
--
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
--------
R
L
V
----
A
-----
S
NGKLI
V
P
P
--
E
---------------
D
R
K
I
G
M
V
F
Q
T
--
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
----
P
R
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
---
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
--
N
E
L
E
G
-----------------------------------
K
--------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
69.66
38%
-104
- C1 -
4YMV
1
?
J:
[2-239]
----
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--------
V
K
I
----
N
-----
N
GKVN-
I
N
K
--
V
---------------
R
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
----
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
68.72
38%
-106
- C1 -
4YMV
1
?
A:
[2-239]
----
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--------
V
K
I
----
N
-----
N
GKVN-
I
N
K
--
V
---------------
R
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
----
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
68.67
35%
-101
- C1 -
1B0U
4
HISP_SALTY
A:
[9-260]
------
V
I
D
L
H
K
R
Y
--
G
-
G
--
H
E
--
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
--------
Q
N
I
----
N
-----
L
-----
V
R
D
--
K
DGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
--
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
--
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
----
P
V
-----------
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
---
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
--
K
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
67.60
38%
-106
- C1 -
4YMU
2
?
A:
[2-239]
----
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--------
V
K
I
----
N
-----
N
GKVN-
I
N
K
--
V
---------------
R
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
----
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
67.10
38%
-101
- C1 -
4YMU
2
?
J:
[2-239]
----
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--------
V
K
I
----
N
-----
N
GKVN-
I
N
K
--
V
---------------
R
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
----
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
66.12
37%
-105
- C1 -
3C4J
4
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.87
37%
-103
- C1 -
2OLJ
4
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.85
37%
-98
- C1 -
2OLK
2
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
65.26
36%
-104
- C1 -
4U00
3
?
A:
[3-241]
--
P
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
--
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV-----
K
D
D
----
R
-----
A
-----
L
R
E
--
I
---------------
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
----
P
A
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
---
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
64.43
37%
-98
- C1 -
3C4J
3
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
64.30
37%
-103
- C1 -
3C41
3
?
K:
[4-241]
----
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
64.25
37%
-103
- C1 -
2OLK
1
?
C:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
64.05
37%
-97
- C1 -
2Q0H
4
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.02
37%
-97
- C1 -
2OLK
1
?
D:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
63.96
37%
-101
- C1 -
2OLK
1
?
A:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAK
D
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
62.86
37%
-97
- C1 -
2Q0H
4
?
A:
[23-262]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
62.48
37%
-102
- C1 -
3C41
3
?
J:
[4-241]
----
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.00
37%
-97
- C1 -
2OLJ
3
?
B:
[22-262]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
--
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--------
I
N
L
KAKD
T
-----
N
-----
L
N
K
--
V
---------------
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
----
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
---
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-
S
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
61.99
36%
-110
- C1 -
1L2T
4
Y796_METJA
B:
[2-225]
----
I
K
L
K
N
V
T
K
T
Y
KM
G
-
E
--
E
I
IY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDLDD
D
E
L
----
T
-----
K
-----
I
----
R
---------------
R
D
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
--
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
-
L
E
E
R
F
ANHK
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
RFG
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
61.55
36%
-111
- C1 -
1L2T
4
Y796_METJA
A:
[2-225]
----
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
--
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDLD
D
D
E
L
----
T
-----
K
-----
I
----
R
---------------
R
D
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
--
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
-
L
E
E
R
F
ANHK
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
58.78
36%
-105
- C1 -
4MKI
4
ECFA2_CALS4
B:
[25-236]
----------------------
V
--
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
--------
I
D
I
----
T
DKKV-
S
-----
L
K
D
--
I
---------------
R
K
Q
V
G
L
V
F
Q
Y
PE
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
G
--
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
S
----
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
---
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
58.29
36%
-100
- C1 -
4MKI
4
ECFA2_CALS4
A:
[25-236]
----------------------
V
--
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
--------
I
D
I
----
T
DKKV-
S
-----
L
K
D
--
I
---------------
R
K
Q
V
G
L
V
F
Q
Y
PE
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
G
--
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
S
----
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
---
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
56.74
36%
-110
- C1 -
3TIF
6
Y796_METJA
B:
[20-225]
-------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDLDD
D
E
L
----
T
-----
K
-----
I
----
R
---------------
R
D
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
--
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
-
L
E
E
R
F
ANHK
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
RFG
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
56.12
36%
-104
- C1 -
3TIF
7
Y796_METJA
A:
[20-225]
-------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDLD
D
D
E
L
----
T
-----
K
-----
I
----
R
---------------
R
D
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
--
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
-
L
E
E
R
F
ANHK
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
49.31
35%
-88
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[367-572]
---------------------------------
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
--------
H
D
I
----
R
-----
Q
-----
L
N
P
V
W
L
---------------
R
S
K
I
G
T
V
S
Q
E
--
P
I
L
F
S
-
C
S
I
A
E
N
I
A
Y
G
----
A
D
--
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
-
F
I
R
N
F
----
P
Q
GFN
T
V
V
G
EK
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
---
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
---
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
47.12
35%
-86
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[367-567]
---------------------------------
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
--------
H
D
I
----
R
-----
Q
-----
L
N
P
V
W
L
---------------
R
S
K
I
G
T
V
S
Q
E
--
P
I
L
F
S
-
C
S
I
A
E
N
I
A
Y
G
----
A
D
--
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
-
F
I
R
N
F
----
P
Q
GFNTVVGEKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
---
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
---
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------