@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2426c: (2016-05-10 )
MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELARAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQRPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTSNATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKKVPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------....-...-..10....---..---..20--...---...-...30........40.------...----------....50........60.....---..-.70-........----.80......---------..90.-.......100....-------------------------------------...110.......120....-----....130.--......140----------...-----------.-------------------..-----------.-----.150....-...160..--.--.....170--......-----..180--------------------------.........190--.-----.---.....200..--------------......210----.......220---.------..------------....230.------.....--.240....-----...250.....-.-.260...----....270.......280.......290--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTVP-ARP-T
P
L
F
A
D
I
A
---
D
V
---
S
R
R
---
L
A
E---TGY-LPDT
A
T
A
T
A
V
F
L
A
D
RL------GK
P
----------
L
L
VEGPAGV
G
K
T
E
L
A
R
A
V
A
Q
A---TG-S
G
--
L
V
R
L
Q
C
YE----G
V
D
E
A
R
A
L
Y
---------
E
W
N
H
A
-
K
Q
I
L
R
I
QAGSGDWE-------------------------------------ATKTDVF
S
E
E
F
L
L
Q
R
-
P
L
L
T
-----
A
I
RRTE
P
T
--
V
L
L
I
DETD-----------KA
D
-----------
I
-------------------
E
I
-----------
E
-----
G
L
L
L
E
V
L
S
-
D
F
A
VT-VP--E--LGTLTAT---RA
P
F
V
L
-----
L
TS----------------------------N
A
T
R
E
L
S
E
A
L
K
R--R-----
C
---
L
Y
L
H
ID-FP
T
--------------
P
E
L
E
R
R
I
L
L
----
S
RVP
E
L
P
E
H
F
---
A
------
E
E
------------
L
V
R
I
I
G
V
L------RGMQL--KKV
P
S
I
A
E
-----
T
I
DWG
R
T
V
L
A
L-G-LDTI
D
D
A
----
V
V
A
A
T
L
G
V
V
LKHQSDQQRATGELRLN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Fugue
80.81
23%
-96
- C5 -
1QVR
7
CLPB_THET8
A:
[4-850]
ERWT
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
KHQAID
L
P
H
L
W
A
V
L
L
KDERS
L
A
W
R
L
L
E
K
A
GAD
P
K
A
L
K
E
L
Q
E
R
E
L
A
R
L
P
K
V
EGAEVGQYLT
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
KDRYVA
V
D
T
L
V
L
A
L
A
E
A
T
PGLPG
L
E
A
L
K
G
A
L
K
ELRGGRTVQTEHAESTYNALEQYGID
L
T
R
L
A
A
E
GKLDPVIGR
D
E
E
I
R
R
V
I
Q
I
L
L
RRTKN
N
P
V
L
I
G
E
P
GVG
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
GDVPEGLKG
K
R
I
V
S
L
Q
ME
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
S
QGE
V
I
L
F
I
DEL
K
P
A
L
A
R
GE
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
E
K
DPALERRFQ
P
V
Y
V
D
EPT
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
YITERRLPD
K
A
I
D
L
I
D
E
A
A
A
R
L
R
M
A
LE
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
E
R
E
A
L
K
K
EKD
P
D
S
Q
E
RL
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
I
E
L
A
E
R
Q
YDLN
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
S
E
K
L
RGARFVRLEVT
E
E
D
I
A
E
I
V
S
R
W
TGIPVSKLLEG
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
-
V
G
Q
-
D
E
A
I
R
A
V
A
---
D
A
---
I
R
R
---
A
R
A
---
G
L
K
-
D
P
N
R
P
I
G
S
F
L
F
L
---------------------------
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
---
L
F
-------------------------------------
D
T
E
-
E
A
M
I
R
I
D
M
T
E
-----------------------------------------------
Y
M
E
K
H
A
V
S
R
L
Q
L
T
E
-----
A
V
R
R
R
P
Y
S
--
V
I
L
F
D
E
I
E
-----------
K
A
H
-----------
P
-------------------
D
V
-----------
F
-----
N
I
L
L
Q
I
L
D
-
D
G
R
L
T
-
D
S
--
H
--
G
R
T
V
D
F
R
---
N
T
V
I
I
L
-----
T
S
N
----------------------------
L
G
S
P
L
I
L
E
G
L
Q
K
-----------------
G
-
W
P
Y
--------------
E
R
I
R
D
E
V
F
K
----
V
L
Q
Q
H
F
R
P
E
F
---
L
------
N
R
------------
L
D
E
I
V
-
V
F
------
R
P
L
T
K
--
E
Q
I
R
Q
I
V
E
------
I
Q
L
S
Y
L
R
A
R
L
-
A
-
E
K
R
I
S
L
E
----
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
GEVKEGDR
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
PA------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.80
24%
-81
- C5 -
4CR2
-
PRS6A_YEAST
M:
[170-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
D
-
E
K
P
-
T
E
T
Y
S
D
V
G
---
G
L
---
D
K
Q
I
E
E
L
V
E
---
A
I
V
-
L
P
M
K
R
A
D
K
F
K
D
M
G
I
R
A
------
P
K
G
----------
A
L
M
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
C
A
A
Q
---
T
N
-
A
T
--
F
L
K
L
-----------------------------
A
A
-
P
Q
L
V
Q
M
Y
I
G
E
G
A
K
--------------------------------------------------
L
V
R
-
D
A
F
A
-----
L
A
K
E
K
A
P
T
--
I
I
F
I
D
E
L
D
AIGTKRFDSEK
S
G
D
-----------
R
-------------------
E
V
-----------
Q
-----
R
T
M
L
E
L
L
N
-----------
Q
--
L
D
G
F
S
S
D
---
D
R
V
K
V
L
-----
A
A
T
----------------------------
N
R
V
D
V
L
D
P
A
L
L
R
--
S
-----
G
R--
L
D
R
K
I
E
-
F
P
L
--------------
P
S
E
D
S
R
A
Q
I
L
Q
I
H
S
R
K
M
T
T
D
D
D
I
---
N
W
-----
Q
E
------------
L
A
R
S
T
D
E
F
------
N
G
A
Q
L
--
K
A
V
----------
T
V
E
A
G
M
I
A
L
R
N
-
G
-
Q
S
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.54
24%
-85
- C5 -
5A5B
-
PRS6A_YEAST
M:
[170-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
D
-
E
K
P
-
T
E
T
Y
S
D
V
G
---
G
L
---
D
K
Q
IEE
L
V
E
---
A
I
V
-
L
P
M
K
R
A
D
K
F
K
D
M
G
I
R
A
------
P
K
G
----------
A
L
M
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
C
A
A
Q
---
T
N
-
A
T
--
F
L
K
L
-----------------------------
A
A
-
P
Q
L
V
Q
M
Y
I
G
E
G
A
K
--------------------------------------------------
L
V
R
-
D
A
F
A
-----
L
A
K
E
K
A
P
T
--
I
I
F
I
D
E
L
D
AIGTKRFDSEK
S
G
D
-----------
R
-------------------
E
V
-----------
Q
-----
R
T
M
L
E
L
L
N
-----------
Q
--
L
D
G
F
S
S
D
---
D
R
V
K
V
L
-----
A
A
T
----------------------------
N
R
V
D
V
L
D
P
A
L
L
R
--
S
-----
G
R--
L
D
R
K
I
E
-
F
P
L
--------------
P
S
E
D
S
R
A
Q
I
LQIH
S
R
K
M
T
T
D
D
D
I
---
N
W-----
Q
E
------------
L
A
R
S
T
D
E
F
------
N
G
A
Q
L
--
K
A
V
----------
T
V
E
A
G
M
I
A
L
R
N
-
G
-
Q
S
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.46
24%
-85
- C5 -
4CR3
-
PRS6A_YEAST
M:
[170-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
D
-
E
K
P
-
T
E
T
Y
S
D
V
G
---
G
L
---
D
K
Q
I
E
E
L
V
E
---
A
I
V
-
L
P
M
K
R
A
D
K
F
K
D
M
G
I
R
A
------
P
K
G
----------
A
L
M
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
C
A
A
Q
---
T
N
-
A
T
--
F
L
K
L
-----------------------------
A
A
-
P
Q
L
V
Q
M
Y
I
G
E
G
A
K
--------------------------------------------------
L
V
R
-
D
A
F
A
-----
L
A
K
E
K
A
P
T
--
I
I
F
I
D
E
L
D
AIGTKRFDSEK
S
G
D
-----------
R
-------------------
E
V
-----------
Q
-----
R
T
M
L
E
L
L
N
-----------
Q
--
L
D
G
F
S
S
D
---
D
R
V
K
V
L
-----
A
A
T
----------------------------
N
R
V
D
V
L
D
P
A
L
L
R
--
S
-----
G
R--
L
D
R
K
I
E
-
F
P
L
--------------
P
S
E
D
S
R
A
Q
I
L
Q
I
H
S
R
K
M
T
T
D
D
D
I
---
N
W
-----
Q
E
------------
L
A
R
S
T
D
E
F
------
N
G
A
Q
L
--
K
A
V
----------
T
V
E
A
G
M
I
A
L
R
N
-
G
-
Q
S
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.81
24%
-81
- C5 -
4CR4
-
PRS6A_YEAST
M:
[170-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
D
-
E
K
P
-
T
E
T
Y
S
D
V
G
---
G
L
---
D
K
Q
I
E
E
L
V
E
---
A
I
V
-
L
P
M
K
R
A
D
K
F
K
D
M
G
I
R
A
------
P
K
G
----------
A
L
M
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
C
A
A
Q
---
T
N
-
A
T
--
F
L
K
L
-----------------------------
A
A
-
P
Q
L
V
Q
M
Y
I
G
E
G
A
K
--------------------------------------------------
L
V
R
-
D
A
F
A
-----
L
A
K
E
K
A
P
T
--
I
I
F
I
D
E
L
D
AIGTKRFDSEK
S
G
D
-----------
R
-------------------
E
V
-----------
Q
-----
R
T
M
L
E
L
L
N
-----------
Q
--
L
D
G
F
S
S
D
---
D
R
V
K
V
L
-----
A
A
T
----------------------------
N
R
V
D
V
L
D
P
A
L
L
R
--
S
-----
G
R--
L
D
R
K
I
E
-
F
P
L
--------------
P
S
E
D
S
R
A
Q
I
L
Q
I
H
S
R
K
M
T
T
D
D
D
I
---
N
W
-----
Q
E
------------
L
A
R
S
T
D
E
F
------
N
G
A
Q
L
--
K
A
V
----------
T
V
E
A
G
M
I
A
L
R
N
-
G
-
Q
S
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Fugue
75.36
24%
-64
- C5 -
4YPL
1
?
C:
[5-542]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSDLEALRKKIEEVGMPEAVKTKALKELDRLERMQQGSPEATVARTYLDWL
T
E
V
P
W
S
K
A
-
D
P
E
V
L
D
I
N
---
H
T
---
R
Q
V
---
L
D
E
---
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
------
L
T
Q
GLDVRNKAPI
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
---
M
N
-
R
K
--
F
H
R
I
S
L
G
G
----
V
R
D
E
A
E
I
R
------------
G
H
R
-
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
-------------------------------------
M
K
Q
V
G
V
I
N
------------------------
P
--
V
I
L
L
D
Q
I
D
-----------
K
M
S
-----------
S
DWRG---------------
D
P
-----------
A
-----
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
-
F
T
--
D
HY
L
D
V
P
Y
D
L
---
S
K
V
F
F
I
-----
T
T
A
----------------------------
N
T
L
Q
T
I
P
R
P
L
L
D
--
R
-----
M
---
E
V
I
E
I
---
P
G
--------------
Y
T
N
M
E
K
Q
A
I
----
A
R
Q
Y
L
W
P
K
Q
V
---
R
------
E
S
GMEGRIEVTDAA
I
L
R
V
I
S
E
Y
TREAGV
R
G
L
E
R
--
E
L
G
K
I
A
R
K
-----
G
A
K
F
W
L
E
G
A
W
E
-
G
-
L
R
T
I
D
A
S
----
D
I
P
T
Y
L
G
I
---
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
TAQGLAWTPVGGTLLTIEVAAVPGSGKLSLTGQLGEVMKESAQAALTYLRAHTQDYGLPEDFYNKVDLHVHVPDGATPKDGPSAGITMATAIASALSRRPARMDIAMTGEVSLRGKVMPIGGVKEKLLAAHQAGIHKIVLPKDNEAQLEELPKEVLEGLEIKLVEDVGEVLEYLLLPEPTMPPVV----------------
131
Fugue
74.16
20%
-99
- C5 -
5C3C
1
?
B:
[26-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
---
P
Y
Y
-
R
A
V
Q
D
E
I
E
L
Y
R
A
G
Y
E
A
------
R
I
P
----------
M
M
L
K
G
P
T
G
C
G
K
S
R
F
V
E
H
M
A
W
K
---
L
N
-
R
P
--
L
I
T
I
A
C
N
E
----
D
M
--------------------------------------------------------------------------------
T
A
S
D
L
V
D
G
-
P
L
T
V
-----
A
A
R
I
G
--
A
--
I
C
Y
L
D
E
I
V
-----------
E
A
R
-----------
Q
-------------------
D
T
-----------
I
------
V
V
I
H
P
L
T
-
D
H
R
R
V
-
L
P
LE
K
--
K
G
E
L
V
E
A
---
H
P
D
F
Q
I
-----
V
I
S
----------------------------
Y
--
N
D
L
K
Q
S
T
K
Q
--
R
-----
F
---
G
A
L
D
F
D
-
Y
P
K
--------------
P
D
I
E
A
E
I
V
S
----
H
E
A
-
G
V
D
K
D
T
---
A
------
E
K
------------
L
V
Q
I
A
Q
K
A
------
R
N
L
K
G
--
H
G
L
D
E
G
L
S
-----
T
R
L
L
V
Y
A
G
K
L
I
-
A
-
K
G
V
D
A
R
A
----
A
C
T
M
T
L
-
V
N
P
I
T
D
D
V
D
M
R
D
A
L
D
T
V
V
K
T
F
F------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
70.23
20%
-77
- C5 -
4CR2
-
PRS6B_YEAST
K:
[167-417]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
D
V
T
-
Y
A
D
V
G
G
L
D
---
M
Q
---
K
Q
E
---
I
R
E
---
A
V
E
-
L
P
L
V
Q
A
D
L
Y
E
Q
I
G
I
D
P
------
P
R
G
----------
V
L
L
Y
G
P
P
G
T
G
K
T
M
L
V
K
A
V
A
N
S
---
T
K
-
A
A
--
F
I
R
V
N
G
S
E
----
F
V
H
K
Y
--
L
G
--------------------------------------------------------------------------
E
G
P
R
M
V
R
-
D
V
F
R
-----
L
A
R
E
N
A
P
S
--
I
I
F
I
D
E
V
D
-----------
S
I
A
TKRFDAQTGSD
R
-------------------
E
V
-----------
Q
-----
R
I
L
I
E
L
L
T
-
Q
M
D
G
------------
F
D
Q
S
---
T
N
V
K
V
I
-----
M
A
T
----------------------------
N
R
A
D
T
L
D
P
A
L
L
R
PG
R
-----
L
D--
R
K
I
E
F
P
S
L
R
D
--------------
R
R
E
R
R
L
I
F
G
----
T
I
A
S
K
M
S
L
A
P
---
E
------
A
D
------------
L
D
S
L
I
I
R
N
------
D
S
--
L
---
S
G
A
V
I
A
A
-----
I
M
Q
E
A
G
L
R
A
V
R
-
K
N
R
Y
V
I
L
Q
S
----
D
L
E
E
A
Y
A
T
Q
V
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Fugue
69.98
21%
-78
- C5 -
4WW4
1
?
A:
[3-458]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QISE
V
R
G
N
T
R
-
D
H
R
-
T
A
A
H
T
H
I
K
---
G
L
GLN
S
S
G
---
I
A
E
KQA
A
G
F
-
V
G
Q
C
A
A
R
E
A
C
G
V
V
V
D
L
------
I
K
A
HKMAG
R
G
---
V
L
L
A
G
G
P
G
T
G
K
T
A
L
A
L
A
I
S
Q
E
---
L
G
-
T
K
I
P
F
C
P
I
T
G
S
E
IYST
E
V
K
K
T
E
V
L
M
---------
E
N
F
R
R
-
A
I
G
L
R
V
R
E
T
K
D
V
Y
E
G
E
VSTLL
I
G
L
K
S
ARGQKLDQKERVQVG
D
V
I
Y
I
E
TNTG
A
C
R
S
D
A
Y
A
T
E
F
D
L
E
A
-
E
E
Y
V
PIPKG
E
V
H
K
K
K
E
I
--
V
Q
D
V
T
L
H
D
-----------
L
D
V
-----------
A
N
A
RPDI
I
S
M
M
G
Q
LMKPKMT
E
I
-----------
T
-----
D
K
L
R
M
E
I
N
-
K
V
V
Q
K
-
Y
I
--
N
--
Q
G
V
A
E
L
I
---
P
G
V
L
F
I
D
EAHM
L
D
I
----------------------------
E
C
F
T
Y
L
N
K
A
L
E
S
--
P
IA
P
I
V
V
---
L
A
S
N
R
G
-
I
A
T
IRGADDLKAAHGIP
P
D
F
L
Q
R
L
L
I
----
I
P
T
H
P
Y
E
P
D
E
---
I
------
R
R
------------
I
V
R
I
R
A
Q
T
------
E
G
V
Q
L
T
D
A
A
V
D
R
V
A
E
H
G
V
R
I
S
L
R
Y
C
L
Q
L
L
A
P
-
A
-
S
I
L
A
R
V
N
GRTQ
V
D
V
Q
D
I
A
E
A
E
E
L
F
L
D
A
R
R
S
A
N
I
L
T
S
T
GGLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Fugue
69.59
19%
-60
- C5 -
1E32
1
TERA_MOUSE
A:
[21-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRPN
R
L
I
VDEAINEDNS
V
V
S
L
S
Q
P
K
M
D
E
L
QLFR
G
D
T
V
L
L
K
G
K
KR
R
E
A
V
C
I
V
L
S
D
DTCSDE
K
I
R
M
N
R
V
V
R
N
N
L
RVRLG
D
V
I
S
I
Q
P
C
PD
V
K
Y
G
K
R
I
H
V
L
P
I
DDTVEGITGNLFEVY
L
K
P
Y
F
LEAY
R
P
I
R
K
G
D
I
F
L
V
R
GGM
R
A
V
E
F
K
VVETDPSPYCIVAPD
T
V
I
H
C
E
G
E
P
I
K
R
E
D
E
E
E
-
S
L
N
-
E
V
G
Y
D
D
V
G
GCR
K
Q
---
L
A
Q
---
I
K
E
---
M
V
E
-
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
------
P
R
G
----------
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
---
T
G
-
A
F
--
F
F
L
I
-----------------------------
N
G
-
P
E
I
M
S
K
L
A
G
--------------------------------------------------
E
S
E
S
N
L
R
-
K
A
F
E
-----
E
A
E
K
N
A
P
A
--
I
I
F
I
D
E
L
D
A
I
A
P-------
K
R
E
-----------
K
-------------------
T
H
-----------
G
-----
E
V
E
R
R
I
V
S
-
Q
L
L
T
L
-
M
D
--
G
--
L
K
Q
---
R
---
A
H
V
I
V
M
-----
A
A
T
----------------------------
N
R
P
N
S
I
D
P
A
L
R
R
--
F
-----
G
RFD
R
E
V
D
I
G
-
I
P
D
--------------
A
T
G
R
L
E
I
L
Q
----
I
H
T
K
N
M
K
L
A
D
DVD
L
------
E
Q
------------
V
A
N
E
T
H
G
H
------
V
G
A
D
L
--
A
A
L
C
S
E
A
A
-----
L
Q
A
I
R
K
K
M
D
L
I
-
D
-
L
E
D
------------------
E
T
I
D
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Fugue
68.72
21%
-88
- C5 -
3M6A
1
LON1_BACSU
A:
[7-531]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGEVQ
T
L
T
E
K
I
E
EAGMPDHVK
E
T
A
L
K
E
L
N
R
YEKIPSSS
A
E
S
S
V
IRN
Y
I
D
W
L
V
A
L
P
-
W
T
D
E
T
D
D
K
L
D
L
K
---
E
A
---
G
R
L
---
L
D
E
---
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
KSLK
G
P
I
----------
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
---
L
G
-
R
K
--
F
V
R
I
S
----------------------------------------------------------------------------------------------
L
G
G
-
R
I
I
Q
-----
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
-----------
K
M
---------------------------------------------------
S
A
M
L
E
V
L
D
-
P
E
Q
N
S
-
S
F
--
S
--
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
-----
A
T
A
----------------------------
N
N
L
A
T
I
P
G
P
L
R
D
--
R
-----
M
---
E
I
I
N
I
A
-
G
Y
T
--------------
E
I
E
K
L
E
I
V
K
----
D
-------
H
L
---
L
------
P
K
------------
Q
I
K
E
H
G
L
K
------
K
S
N
L
Q
--
L
R
D
Q
A
I
L
D
-----
I
I
R
Y
Y
--
T
R
E
A
-
G
-
V
R
S
L
E
R
Q
----
L
A
A
I
C
R
K
A
A
K
A
I
V
A
E
E
R
K
---
R
I
T
V
T
EKNLQDFIGKRIFRYGQA
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
TV
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
KLG
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
KTEELGIEPDFHEK
Y
D
I
H
I
H
V
P
E
GAVPKDGPAA
G
I
T
M
A
T
A
L
V
S
A
L
T
GRAVSRE
V
G
M
T
G
E
I
T
LRG
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
GLT
T
I
I
A
P
KDNEKDIEDIP
E
S
V
R
E
G
LT
F
I
L
A
SH
L
D
E
V
L
E
H
A
L
V
8
PsiBlast_PDB
68.63
27%
-115
- C4 -
1QVR
3
CLPB_THET8
A:
[570-709]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
---
D
A
---
I
R
R
---
A
R
A
---
G
L
K
-
D
P
N
R
P
I
G
S
F
L
F
L
---------------------------
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
-
E
A
--
M
I
R
I
D
M
T
E
------------
Y
---------
M
E
K
H
A
V
S
R
L
---------------------------------------------------
Q
-------------
L
T
E
-----
A
V
R
R
R
P
Y
S
--
V
I
L
F
D
E
I
E
-----------
K
A
H
-----------
P
-------------------
D
V
-----------
F
-----
N
I
L
L
Q
I
L
D
-
D
G
R
L
T
-
D
S
--
H
---
G
R
T
V
D
F
---
R
N
T
V
I
I
-----
L
T
S
----------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
68.49
19%
-110
- C5 -
5C3C
1
?
A:
[37-247]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
Y
R
A
G
Y
E
A
------
R
I
P
----------
M
M
L
K
G
P
T
G
C
G
K
S
R
F
V
E
H
M
A
W
K
---
L
N
-
R
P
--
L
I
T
I
A
C
N
E
----
D
M
T
A
S
D
L
V
G
---------
R
---------------------------------------------------------------------
D
G
-
P
L
T
V
-----
A
A
R
--
I
G
A
--
I
C
Y
L
D
E
I
V
-----------
E
A
R
-----------
Q
-------------------
D
T
-----------
I
-----
V
V
I
H
P
L
T
D
-
H
R
R
V
L
P
L
E
--
K
K-
G
E
L
V
E
A
H
---
P
D
F
Q
I
V
-----
I
S
Y
----------------------------
N
P
--
D
L
K
Q
S
T
K
Q
--
R
-----
F
---
G
A
L
D
F
D
-
Y
P
K
--------------
P
D
I
E
A
E
I
V
S
----
H
E
A
-
G
V
D
K
D
T
---
A
------
E
K
------------
L
V
Q
I
A
Q
K
A
------
R
N
-------
G
L
S
T
R
L
-----
L
V
Y
A
G
K
L
I
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
HHSearch
66.39
23%
-72
- C5 -
2X8A
2
A:
[12-204]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
L
E
---
D
I
---
R
E
E
---
L
T
M
---
A
I
L
-
A
P
V
R
N
P
D
Q
F
K
A
L
G
L
V
T
------
P
A
G
----------
V
L
L
A
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
N
E
---
S
G
-
L
N
--
F
I
S
V
K
G
P
E
----
L
L
N
M
Y
V
--
G
--------------------------------------------------------------------------
E
S
E
R
A
V
R
-
Q
V
F
Q
-----
R
A
K
N
S
A
P
C
--
V
I
F
F
D
E
V
D
-----------
A
L
C
PS---------
V
-------------------
R
V
-----------
V
-----
N
Q
L
L
T
E
M
D
-
G
L
E
---------------
A
R
---
Q
Q
V
F
I
M
-----
A
A
T
----------------------------
N
R
P
D
I
I
D
P
A
I
L
R
PG
R
-----
L
D--
K
T
L
F
V
G
-
L
P
P
--------------
P
A
D
R
L
A
I
L
K
----
T
I
T
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.23
26%
-116
- C4 -
4FCT
-
CLPB_THET8
A:
[570-709]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
---
D
A
---
I
R
R
---
A
R
A
---
G
L
K
-
D
P
N
R
P
I
G
S
F
L
F
L
---------------------------
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
-
E
A
--
M
I
R
I
D
M
T
E
------------
Y
---------
M
E
K
H
A
V
S
R
L
---------------------------------------------------
Q
-------------
L
T
E
-----
A
V
R
R
R
P
Y
S
--
V
I
L
F
D
A
I
E
-----------
K
A
H
-----------
P
-------------------
D
V
-----------
F
-----
N
I
L
L
Q
I
L
D
-
D
G
R
L
T
-
D
S
--
H
---
G
R
T
V
D
F
---
R
N
T
V
I
I
-----
L
T
S
----------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
HHSearch
66.12
25%
-64
- C5 -
1IXZ
5
FTSH_THET8
A:
[10-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
-
K
V
T
-
F
K
D
V
A
G
A
E
---
E
A
---
K
E
E
---
L
K
E
---
I
V
E
-
F
L
K
N
-
P
S
R
F
H
E
M
G
A
R
I
------
P
K
G
----------
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
---
A
R
-
V
P
--
F
I
T
A
S
G
S
D
----
F
V
E
M
F
--
V
G
---------
V
-----------------------------------------------------------------
G
A
A
R
V
R
-
D
L
F
E
-----
T
A
K
R
H
A
P
C
--
I
V
F
I
D
E
I
D
-----------
A
V
G
-----------
R
---------------------------------N
D
E
R
E
Q
T
L
N
Q
L
L
V
-
E
M
D
------------
G
F
E
K
D
---
T
A
I
V
V
M
-----
A
A
T
----------------------------
N
R
P
D
I
L
D
P
A
L
L
R
PG
R
-----
F
D--
R
Q
I
A
I
D
-
A
P
D
--------------
V
K
G
R
E
Q
I
L
R
----
I
H
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.79
26%
-97
- C4 -
4LJ7
2
CLPB_THET8
A:
[55-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
---
D
A
---
I
R
R
---
A
R
A
---
G
L
K
-
D
P
N
R
P
I
G
S
F
L
F
L
---------------------------
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
FD
T
E
-
E
A
--
M
I
R
I
D
M
T
E
------------
Y
---------
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
-------------------------------------
E
G
G
Q
-------------
L
T
E
-----
A
V
R
R
R
P
Y
S
--
V
I
L
F
D
E
I
E
-----------
K
A
H
-----------
P
-------------------
D
V
-----------
F
-----
N
I
L
L
Q
I
L
D
-
D
G
R
L
T
-
D
S
--
H
---
G
R
T
V
D
F
---
R
N
T
V
I
I
-----
L
T
S
----------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.71
26%
-99
- C4 -
4FD2
1
CLPB_THET8
A:
[26-165]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
---
D
A
---
I
R
R
---
A
R
A
---
G
L
K
-
D
P
N
R
P
I
G
S
F
L
F
L
---------------------------
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
FD
T
E
-
E
A
--
M
I
R
I
D
M
T
E
------------
Y
---------
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
-------------------------------------
E
G
G
Q
-------------
L
T
E
-----
A
V
R
R
R
P
Y
S
--
V
I
L
F
D
A
I
E
-----------
K
A
H
-----------
P
-------------------
D
V
-----------
F
-----
N
I
L
L
Q
I
L
D
-
D
G
R
L
T
-
D
S
--
H
---
G
R
T
V
D
F
---
R
N
T
V
I
I
-----
L
T
S
----------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Fugue
65.51
17%
-67
- C3 -
1G8P
-
BCHI_RHOCB
A:
[18-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
-
V
F
P
F
S
A
I
V
---
G
--------------------
Q
E
D
M
K
L
A
L
L
L
T
A
V
D
P
G
------
I
G
G
----------
V
L
V
F
G
D
R
G
T
G
K
S
T
A
V
R
A
L
A
A
L
---
L
P
-
E
I
--
E
A
V
E
G
C
P
V
----
S
S
P
N
V
E
M
I
P
DWATVLST
N
V
I
R
K
P
-
T
P
V
V
D
L
P
L
G
V
S
E
D
R
-------------------------------------
V
V
G
A
L
D
I
E
R
A
I
S
K
G
E
-
K
A
F
E
P
G
---
L
L
A
R
A
N
R
G
--
Y
L
Y
I
D
E
C
N
-----------
L
L
E
-----------
D
-------------------
H
I
-----------
V
-----
D
L
L
L
D
V
A
Q
-
S
G
E
N
V
-
V
E
--
R
--
D
G
L
S
I
R
H
---
P
A
R
F
V
L
-----
V
G
S
G
N
PEEGDLR
P
Q
L
L
D
R
FG
L
S
V
E
V
L
S
PRD
V
E
T
R
V
E
V
I
R
R
R
D
T
--
Y
-----
D
---
A
D
P
K
A
F
-
L
E
E
--------------
W
R
P
K
D
M
D
I
R
----
N
Q
I
L
E
A
R
E
R
L
---
P
K
V
E
A
P
N
T
A
------------
L
Y
D
C
A
A
L
C
------
I
A
L
G
S
--
D
G
L
R
G
E
L
T
-----
L
L
R
S
A
R
A
L
A
A
L
E
G
-
A
T
A
V
G
R
D
----
H
L
K
R
V
A
T
M
A
L
S
H
R
L
R
V
A
R
T
V
E
E
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
65.46
22%
-83
- C5 -
1XWI
2
VPS4B_HUMAN
A:
[5-195]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
-
N
V
K
-
W
S
D
V
A
G
L
E
---
G
A
---
K
E
A
---
L
K
E
---
A
V
I
-
L
P
I
K
F
P
H
L
F
-
T
G
K
R
T
P
------
W
R
G
----------
I
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
E
---
A
N
N
S
T
--
F
F
S
I
S
S
S
D
----
L
V
S
K
W
--
L
G
--------------------------------------------------------------------------
E
S
E
K
L
V
K
-
N
L
F
Q
-----
L
A
R
E
N
K
P
S
--
I
I
F
I
D
E
I
D
-----------
S
L
C
-----------
G
-------------------
S
R
SENESEA
A
R
R
I
K
-----
T
E
F
L
V
Q
M
Q
-
G
V
G
--------------
V
D
N
---
D
G
I
L
V
L
-----
G
A
T
----------------------------
N
I
P
W
V
L
D
S
A
I
R
R
--
R
-----
F
E--
K
R
I
Y
I
P
-
L
P
E
--------------
P
H
A
R
A
A
M
F
K
----
L
H
L
G
T
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------