@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2467: (2016-05-11 )
MALPNLTRDQAVERAALITVDSYQIILDVTDGNGAPGERTFRSTTTVVFDALPGADTVIDISAHTVRRASLNDQDLDVSGYDEAAGIPLRGLAQRNVVVVDADCHYSNTGEGLHRFVDPVDGETYLYSQFETADAKRMFACFDQPDLKATFDVRVTAPAHWKVISNGAPLAAANGVHTFATTPRMSTYLVALIAGPYAAWTDTYIDDHGEIPLGIYCRASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAFGKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWDDLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLERFLAGLRDYFRTHAFGNASFDDLLAALEKASGRDLSNWGEQWLKTTGLNTLRPDFEVDAEGRFTRFAVTQSGAAPGAGETRVHRLAVGIYDDDGSKSSGKLVRVHREELDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSLQTALDRIADIAEPLPRTLVWSAAWEMTREAELRARDFVSLVSGGVHAETEVGVAQRLLLQAQTALGCYAEPGWARERGWPQFADRLLELAREAEPGSDHQLAYINSLCSSVLSPRHVQTLGALLEGEPAACGLAGLAVDTDLRWRIVTALATAGAIDADGPETPRIDAEVQRDPTAAGKRHAAQARAARPQFVVKDEAFTTVVEDDTLANATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARRSSEVAQSVVIGLYPHWDISEQGITAAEEFLSDPEVPPALRRLVLEGQAAVQRSLRARNFDADG
Atome Classification :
(36 SA)
.........10........20....-----....30........40........50--.-.......------60---........----.70.----.---------.------------.----------.----...---80-.--.--.-....-.90-...----.----..----...---100.....--.--.110.......--..120--.--.--.....--.-.130.......140.......150.....--..-160.-........170-...--------.--------.---.------.------..180.......190.......200..-.-....-210.......---..220..-.....230.......240.......250.........260.......270.....-.-.280--....-....--290-.---.....-.300.......310.......320.......330.......340--.......--.350.-...-------------...360....---...---370.......380.......390.......400.......410.......420.......430--------.---------------------------.--------.....440.......---450.......460.......470.......--------480....---....490---...-...--------..500..------..------...510..------.-....520--..-----------------.-----...-----...530.......540.......550.......---560-.------------...---.....-570.....-----..580.-----..-.-...590....---.-..--600.......610.-......620---.---..--..----..630.......-----640--------.-----------.-----------.-....-----650.......660....-...-670.......680...-.--....690.......-700..---..-...710.......720..----.....730.......740.......---750....--.-..760.......770--..-..---.---..780--..--.....--.--.790.----......800.......810..-.....820.......830----..-.-......840.......--850.......860
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALPNL
T
R
D
Q
A
VE
R
A
A
L
I
T
V
D
S
Y
Q
I
-----
I
L
D
VTDGNGAPGE
R
T
FR
S
T
T
T
V
V
F
DA--L-PGA
D
T
V
I
------
D
----ISA
H
T
V
R
R----ASLN----D---------Q------------D----------L----DVS---GY-D--E--A-AGIP-LR--GLA----Q----R
N
----
V
V
V
---
V
DADCHYS--N--
T
G
--
E
G
L
H
R
F
V--DPV----D--G--E
T
Y
L
Y
--
S
-QFETA
D
A
K
R
M
F
A
CFDQPD
L
K
A
T
F
D
V
R
V
TA--P
A
-
H
--
W
-
K
V
ISNGAPL---AAA--------N--------G---
V
------
H
------
T
FATTPRM
S
T
Y
L
V
A
L
IAGPYAAWTDTY-I-DDHG-E--I
P
L
G
I
Y
C
---
R
A
S
L
A
E
Y
-
M
D
A
E
R
L
F
T
Q
T
K
Q
GF
G
F
Y
H
K
HFGLPYA--FGKYD
Q
L
F
VPEFNAGAMENAG
A
V
T
F
L
E
-
D
-
Y
V
-
F
--
R
S
K
V
-
T
R
A
S
--
Y
E
R
-
R
---
A
E
T
V
L
-
H
E
M
A
H
M
W
F
GD
L
V
T
M
T
WWDDLWLN
E
S
F
A
T
F
A
S
V
L
C
Q
S
E
A
T
E
F
T
-
E
--
A
W
T
T
F
A
T
--
V
E
K
SW-AYR-------------QDQLPSTHPI---AAD---IP
D
L
A
A
V
E
V
NFDGITYA
K
G
A
S
V
L
K
Q
L
V
A
Y
V
G
L
E
R
F
L
A
G
L
R
D
Y
F
R
T
HAFGNA
S
F
D
D
L
L
A
A
L
E
KA--------S---------------------------G--------RD
L
S
N
W
G
E
Q
W
L
K
TTG---LNTLRPD
F
E
VDAEG
R
F
T
R
F
A
V
TQSGAAPGA--------G-E
T
R
V
H
---
R
L
A
V
G
I
----YDD-DGS--------KSS
G
K
L
V
------
R
V
------
H
R
E
ELDVS------G-PITNV----
P
A
-----------------
L
-----
V
GV-----SRG
K
L
I
L
V
NDDD
L
T
Y
C
S
L
RL
D
E
R
S
L
Q
T
A
L
D
R
I
A
---
D
---
I
------------
A
EP---L
P
R
T
L
-
V
W
S
A
A
W
E
M
-----
T
R
E
A
E
L
-----
R
A
-
R
-
D
F
V
S
L
V
SGGV---H-
A
E
--
T
E
V
G
V
A
Q
R
L
L
L
Q
A
Q-TALGCYAEP---G---WA--RE----RG
W
P
Q
F
A
D
R
L
L
E
-----
L
A
R--------E-----------A-----------E-PGSD-----
H
Q
L
A
Y
I
N
S
L
C
S
S
VLSP
R
-
H
V
Q
-
T
L
G
A
L
LEGEPAA-CGL-A--G
L
A
VDTD
L
R
W
R
I
V
T
-ALATA---GA-IDADGPETPRID
A
E
VQRD----PTAAGK
R
H
A
A
Q
ARAARP
Q
F
V
V
KDE
A
---
F
T
T
V
VED--D-TLANATG
R
A
M
I
A
G
IA--AP-GQ---
G
---
E
L
L
----
K
P
--
F
A
R
R
Y
--
F
--
Q
AI
P
G
----
V
W
A
R
R
S
S
E
V
A
Q
S
V
V
I
G
LYPHW-DISEQ
G
I
T
A
A
E
E
F
LSD------PE-V-
P
P
A
L
R
R
L
V
LE
G
Q
A
A
V
Q
--
R
S
L
R
ARNFDADG
65
Fugue
96.36
23%
-72
- C5 -
1Z1W
2
TRF3_THEAC
A:
[1-780]
-----------------
M
E
V
E
K
Y
D
L
-----
T
L
D
F
D
-----
I
Q
K
R
T
F
N
G
T
E
T
I
T
A
D
A
------
G
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
T
---
Y
D
-
G
--
Q
--
T
-
V
R
A
P
-
G
D
--
S
------
Q
----
P
Q
----
K
I
E
---
I
S
F
A
G
K
V
S
--
D
--
S
L
--
S
G
I
Y
Y
A
G
--
R
E
-----------
N
G
M
I
T
--
T
-
H
F
E
A
T
D
A
R
R
M
F
P
C
V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
Y
-
D
A
I
S
N
M
P
P
K
---
R
I
E
--------
V
--------
S
E
R
K
V
------
V
------
E
F
Q
D
T
P
R
M
S
T
Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
-
R
-
D
-----------
I
D
L
---
I
L
A
S
L
K
D
-
I
R
S
K
Y
P
L
D
M
A
R
K
S
V
E
F
Y
E
N
Y
F
G
I
P
Y
A
--
L
P
K
M
H
L
I
S
V
P
E
F
G
A
G
A
M
E
N
W
G
A
I
T
F
R
E
-
I
-
Y
M
D
I
--
A
E
N
S
-
A
V
T
V
--
K
R
N
-
S
---
A
N
V
I
A
-
H
E
I
A
H
Q
W
F
G
D
L
V
T
M
K
W
W
N
D
L
W
L
N
E
S
F
A
T
F
M
S
Y
K
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D
T
L
F
P
E
W
-
S
--
F
W
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D
F
F
V
--
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R
T
S
G
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A
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R
-------------
S
D
S
L
K
N
T
H
P
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---
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D
---
V
R
D
P
D
E
I
S
Q
I
F
D
E
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Y
G
K
G
A
S
I
L
R
M
I
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D
Y
A
G
Y
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E
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R
K
G
I
S
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Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
----
P
V
I
K
L
K
R
N
G
--
R
K
I
T
M
Y
Q
T
R
F
L
L
N
G
--------
E
-
E
E
G
R
W
---
P
V
P
V
N
I
----
K
K
K
-
D
G
--------------------------------------------
V
-
E
R
I
L
L
----
E
D
-----------------
E
-----
A
S
I
-----
E
A
D
G
L
I
K
I
N
A
D
S
A
G
F
Y
R
V
L
Y
D
D
A
T
F
S
D
V
M
G
H
Y
R
---
D
---
L
-------------
S
P
---
L
D
R
I
G
-
L
V
D
D
L
F
A
F
-----
L
L
S
G
H
I
-----
D
P
-
E
-
T
Y
R
Q
R
I
R
N
-
F
---
F
-
D
D
--
E
D
H
N
V
I
T
A
I
V
G
Q
M
E
-
Y
L
R
M
L
T
H
A
F
------------
D
----
D
D
A
R
A
F
C
R
S
R
M
Q
-----
F
L
T
--------
G
-----------
K
-----------
Q
-
D
E
N
L
-----
K
I
A
L
G
R
V
S
R
L
Y
V
M
V
D
E
S
-
Y
A
E
-
E
M
S
K
L
F
K
D
F
D
S
------------
A
E
P
E
M
R
S
S
I
A
T
-
A
Y
A
L
V
---
T
-------
G
D
L
K
G
L
L
E
K
F
R
S
V
----
D
R
D
E
D
R
V
R
I
I
S
A
F
G
K
L
K
S
N
T
D
L
S
T
V
---
Y
G
M
V
E
K
T
--
E
-
I
K
K
Q
D
M
I
S
F
F
S
S
A
L
E
--
T
L
-
P
G
---
R
---
E
F
I
----
F
A
--
N
L
D
R
I
--
I
--
R
L
V
I
R
----
Y
F
T
--
G
N
R
T
A
S
R
T
V
E
M
M
I
P
V
I
-
G
L
D
H
P
D
A
E
D
I
V
R
N
I
G
S
------
K
N
-
I
-
S
M
G
L
A
K
G
I
E
M
L
A
V
N
R
K
--
L
V
E
R
I
R
Q
T
A
V
K
-
48
HHSearch
93.59
23%
-76
- C5 -
1Z5H
14
TRF3_THEAC
A:
[2-776]
------------------
E
V
E
K
Y
D
L
-----
T
L
D
F
D
I
Q
-----
K
R
T
F
N
G
T
E
T
I
T
A
D
A
----
G
--
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
----
T
Y
-
D
--
G
--
Q
--
T
V
R
-
A
P
---
G
D
----
S
Q---
P
Q
----
K
I
E
---
I
S
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A
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K
V
S
--
D
--
S
L
--
S
G
I
Y
Y
A
G
---------
R
--
E
--
N
G
M
I
T
--
T
-
H
F
E
A
T
D
A
R
R
M
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P
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V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
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-
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A
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S
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M
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K
---
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S
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--------
K
---
V
------
V
------
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F
Q
D
T
P
R
M
S
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Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
------
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-
D
--
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D
L
I
L
A
S
---
L
K
D
I
--
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---
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K
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P
L
D
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A
R
K
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F
Y
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N
Y
F
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Y
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L
P
K
M
H
L
I
S
V
P
E
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G
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G
A
M
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N
W
G
A
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F
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I
Y
-
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N
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G
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T
S
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A
L
R
-------------
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D
S
L
K
N
T
H
P
I
---
E
V
D
---
V
R
D
P
D
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I
S
Q
I
F
D
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I
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Y
G
K
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A
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R
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Y
A
G
Y
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F
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K
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I
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Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
P
V
I
K
L
K
R
N
G
R
------
K
I
T
M
Y
Q
T
R
F
L
L
N
G
-----------
E
E
E
G
---
R
W
P
V
P
V
N
---
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K
K
-
K
-
D
------------
G
-
V
----------------
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R
I
L
L
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------
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-
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A
---------------------------------
S
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-----
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A
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G
L
I
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I
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A
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A
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F
Y
R
V
L
Y
D
D
A
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F
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D
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M
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H
Y
R
---
D
----------------
L
S
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---
L
D
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-
L
V
D
D
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F
A
F
-----
L
L
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G
H
I
-----
D
P
-
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Y
R
Q
R
I
R
N
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F
---
F
-
D
D
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D
H
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T
A
I
V
G
Q
M
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--
Y
L
R
M
L
T
H
A
------------------
F
D
D
D
A
R
A
F
C
R
S
-----
R
M
Q
--------
F
-----------
L
TG---------
K
-
Q
D
E
N
-----
L
K
I
A
L
G
R
--
V
S
R
L
Y
V
M
V
-
D
E
S
-
Y
A
E
E
M
S
K
--
L
F
K
D
F
-------
D
S
A
E
P
E
M
R
S
S
I
A
T
A
Y
A
L
V
T
---
G
----
D
----
L
K
G
L
L
E
K
F
R
S
V
----
D
R
D
E
D
R
V
R
I
I
S
A
F
G
K
L
K
S
N
T
D
L
S
T
V
---
Y
G
M
V
E
K
T
----
E
I
K
K
Q
D
M
I
S
F
F
S
S
A
L
E
-
T
L
P
G
R
---
E
--------------
F
I
F
A
N
--
L
--
D
R
I
I
R
L
V
I
R
Y
F
T
-
G
-
N
R
T
A
S
R
T
V
E
M
M
I
P
V
I
G
L
D
H
P
D
-
A
E
D
I
V
R
N
I
G
------------
S
K
N
I
S
M
G
L
A
K
G
I
E
M
L
A
--
V
N
R
K
L
V
E
R
I
R
Q
-
42
HHSearch
93.54
18%
-68
* C5 *
5AB0
12
ERAP2_HUMAN
A:
[70-950]
--------------
P
S
V
V
I
P
L
H
Y
D
L
-----
F
V
H
P
N
L
T
-----
S
L
D
F
V
A
S
E
K
I
E
V
L
V
S-
N
-
A
T
Q
F
I
I
L
------
H
----
S
K
D
L
E
I
T
N
----
A
T
L
Q
----
S
---------
E
------------
E
DSRYMKP
G
K
E
L
----
K
V
L
---
S
Y
P
A
--
H
--
E
Q
I
A
L
L
-
V
P
E-
K
L
T
P---
H
L
---
K
Y
----
Y
V
A
---
M
D
F
Q
A
K
L
G
--
D
--
G
F
--
E
G
F
Y
K
S
T
--
Y
R
T
L---
G
--
G
E
T
R
I
L
A
V
--
T
-
D
F
E
P
T
Q
A
R
M
A
F
P
C
F
D
E
P
L
F
K
A
N
F
S
I
K
I
R
R
--
E
S
-
R
--
H
-
I
A
L
S
N
M
P
K
V
---
K
T
I
E
L
EGG---
L
--------
L
---
E
------
D
------
H
F
E
T
T
V
K
M
S
T
Y
L
V
A
Y
I
V
C
D
F
H
S
L
S
G
F
T
-----
S
S
-
G
--
V
K
V
S
I
Y
A
---
S
P
D
K
R
N
Q
---
T
H
Y
A
L
Q
A
S
L
K
L
L
D
F
Y
E
K
Y
F
D
I
Y
Y
P
--
L
S
K
L
D
L
I
A
I
P
D
F
A
P
G
A
M
E
N
W
G
L
I
T
Y
R
E
T
S
-
L
L
-
F
--
D
P
K
T
S
S
A
S
D
--
K
L
W
-
V
---
T
R
V
I
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
M
E
W
W
N
D
I
W
L
N
E
G
F
A
K
Y
M
E
L
I
A
V
N
A
T
Y
P
E
L
-
Q
--
F
D
D
Y
F
L
---
N
V
C
F
E
-
V
I
T
-------------
K
D
S
L
N
S
S
R
P
I
---
S
K
P
---
A
E
T
P
T
Q
I
Q
E
M
F
D
E
V
S
Y
N
K
G
A
C
I
L
N
M
L
K
D
F
L
G
E
E
K
F
Q
K
G
I
I
Q
Y
L
K
K
F
S
Y
R
N
A
K
N
D
D
L
W
S
S
L
S
N
S
--------
C
LESDFTSGGVCHSDPKMT
S
N
M
L
A
F
L
G
E
N
--------
A
E
V
K
E
M
M
T
T
W
T
L
Q
K
G
---
I
P
L
L
V
V
K
Q
D
G
C
------
S
L
R
L
Q
Q
E
R
F
L
Q
G
V
FQEDPE
W
R
A
-
L
Q
E
R
Y
---
L
W
H
I
P
L
T
---
Y
S
T
-
S
S
S
------------
N
---------
V
-------
I
H
R
H
I
L
K
------
S
-
K
T
D
T
L
----
D
-------------------------
L
P
-----
E
K
T
S
W
V
K
F
N
V
D
S
N
G
Y
Y
I
V
H
Y
E
G
H
G
W
D
Q
L
I
T
Q
L
N
---
Q
NHT
L
------------
L
R
P
---
K
D
R
V
G
-
L
I
H
D
V
F
Q
L
-----
V
G
A
G
R
L
-----
T
L
-
D
-
K
A
L
D
M
T
-
Y
Y
L
---
Q
-
H
E
--
T
S
S
P
A
L
L
E
G
L
S
Y
L
E
--
S
F
Y
H
M
M
D
R
---
R
---
N
---
I
S
----
D
I
S
E
N
L
K
R
Y
L
L
Q
-----
Y
F
K
--------
P
-----------
V
I
D
R
QSW-----
S
-
D
K
G
S
-----
V
W
D
R
M
L
R
S
A
L
L
K
L
A
C
D
L
N
H
A
P
-
C
I
Q
K
A
A
E
--
L
F
S
Q
W
M
E
-
S
S
G
K
L
N
I
P
T
D
V
L
K
I
V
Y
S
-
V
G
A
Q
T
------
T
A
G
----
W
N
Y
L
L
E
Q
Y
E
L
S
----
M
S
S
A
E
Q
N
K
I
L
Y
A
L
S
T
S
K
H
Q
E
K
L
L
K
L
---
I
E
L
G
M
E
G
--
K
-
V
I
K
T
Q
N
L
A
A
L
L
H
A
I
A
R
-
R
P
K
G
Q
---
Q
----
L
A
----
W
D
--
F
V
R
E
N
--
W
--
T
H
L
L
K
----
K
F
D
L
G
S
-
Y
D
I
R
M
I
I
S
G
T
T
A
H
F
-
S
S
K
D
K
-
L
Q
E
V
K
L
F
F
E
S
------
L
E
-
A
-
Q
G
S
H
L
D
I
F
Q
T
V
L
E
T
I
T
--
K
N
I
K
W
L
E
K
N
L
P
-
47
HHSearch
91.63
20%
-72
- C5 -
4FKE
12
AMPN_PIG
A:
[12-892]
--------------
P
T
T
L
L
P
D
S
Y
N
V
-----
T
L
R
P
Y
L
T
P
N
A
D
G
L
Y
I
F
K
G
K
S
I
V
R
F
L
C
Q-
E
-
P
T
D
V
I
I
I
------
H
----
S
K
K
L
N
Y
T
T
QGHM
V
V
L
R
----
G
---------
V
GD
S
Q
--------
V
----------
P
----
E
I
D
R
T
-
E
L
-
V
EL
T
--
E
Y
L
V
V
H
-
L
K
G
-
S
L
Q
P
---
G
H
---
M
Y
----
E
M
E
---
S
E
F
Q
G
E
L
A
--
D
--
D
L
--
A
G
F
Y
R
S
E
--
Y
M
E
GN--
V
--
K
--
K
V
L
A
T
--
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
TPLAEDPN
W
--------
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
A
-----
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
N
A
-
L
L
-
F
--
D
P
Q
S
S
S
I
S
N
--
K
E
R
-
V
---
V
T
V
I
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
E
P
T
W
-
N
--
L
K
D
L
I
V
P
--
G
D
V
Y
R
-
V
M
A
-------------
V
D
A
L
A
S
S
H
P
L
---
T
T
P
AEE
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
--------
V
---------------------------
D
A
Q
TSIRLP
D
T
V
R
A
I
M
D
R
W
T
L
Q
M
G
---
F
P
V
I
T
V
D
T
K
T
--------
G
N
I
S
Q
K
H
F
L
L
D
S
ESNVTR--
S
-
S
A
F
D
Y
---
L
W
I
V
P
I
S
---
S
I
K
-
N
G
-------------
V
M
----------------
Q
D
H
Y
W
L
R
------
D
-
V
S
Q
A
Q
----
N
D
-----------------
L
-----
F
K
T
-----
A
S
D
D
W
V
L
L
N
V
N
V
T
G
Y
F
Q
V
N
Y
D
E
D
N
W
R
M
I
Q
H
Q
L
Q
T
NL
S
---
V
------------
I
P
V
---
I
N
R
A
Q
-
V
I
Y
D
S
F
N
L
-----
A
T
A
H
M
V
-----
P
V
-
T
-
L
A
L
D
N
T
L
-
F
L
---
N
-
G
E
--
K
E
Y
M
P
W
Q
A
A
L
S
S
L
S
--
Y
F
S
L
M
F
D
R
---
S
-------------
E
V
Y
G
P
M
K
K
Y
L
R
K
-----
Q
V
E
--------
P
-----------
L
F
Q
H
F
E
T
L
T
KNW
T
E
R
P
E
N
-----
L
M
D
Q
Y
S
E
I
N
A
I
S
T
A
C
S
N
G
L
P
Q
-
C
E
N
L
A
K
T
--
L
F
D
Q
W
M
S
-
D
PE
N
N
P
I
H
P
N
L
R
S
T
I
Y
C
-
N
A
I
A
Q
---
G
G
-
Q
D
Q
----
W
D
F
A
W
G
Q
L
Q
Q
A
----
Q
L
V
N
E
A
D
K
L
R
S
A
L
A
C
S
N
E
V
W
L
L
N
R
Y
---
L
G
Y
T
L
N
P
--
D
-
L
I
R
K
Q
D
A
T
S
T
I
N
S
I
A
S
-
N
V
I
G
Q
---
P
----
L
A
----
W
D
--
F
V
Q
S
N
--
W
--
K
K
L
F
Q
----
D
Y
G
G
G
-
S
F
S
F
S
N
L
I
Q
G
V
T
R
R
F
-
S
S
E
F
E
-
L
Q
Q
L
E
Q
F
K
K
N
------
N
M
D
V
G
F
G
S
G
T
R
A
L
E
Q
A
L
E
K
T
K
--
A
N
I
K
W
V
K
E
N
K
E
-
67
Fugue
91.44
22%
-64
- C5 -
4WZ9
4
?
A:
[40-926]
---
Q
A
V
D
E
R
Y
R
L
P
T
T
S
I
P
I
H
Y
D
L
H
L
-----
R
T
E
I
H
R
N
-----
E
R
T
F
T
G
T
V
G
I
Q
L
Q
V
--
V
-
Q
A
T
D
K
L
V
------
M
H
N
R
G
L
V
M
S
S
A
K
V
----
S
S
L
P
----
N
GVT
G
A
P
T
L
I
G
------------
D
----------
V
----
Q
Y
S
---
T
D
-
T
--
T
--
F
-
E
H
I
T
-
F
T
--
S
P
T
----
I
L
Q
P
G
T
Y
----
L
L
E
---
V
A
F
Q
G
R
L
A
--
T
--
N
D
--
D
G
F
Y
V
S
S
--
Y
V
A
----
D
NG
E
--
R
R
Y
L
A
--
T
T
Q
F
E
S
T
S
A
R
M
A
F
P
C
Y
D
E
P
G
L
K
A
T
F
T
V
S
I
T
H
--
S
L
-
S
--
Y
-
K
A
I
S
N
M
P
Q
K
---
T
T
T
--------
D
I
ET
D
M
---
R
---
T
------
T
------
F
F
E
K
T
P
A
M
S
T
Y
L
L
A
F
V
V
S
D
F
------
Q
-
L
-
R
L
S
G
-----
A
Q
R
V
Y
V
---
R
P
N
A
F
N
E
---
A
T
F
A
L
E
A
G
V
K
I
L
K
V
L
D
D
H
L
G
I
P
Y
D
TY
M
P
K
L
D
Q
I
A
I
P
D
F
A
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
Q
-
A
L
-
L
--
F
N
P
--
A
V
S
T
--
Y
R
G
-
K
T
N
V
A
T
T
I
A
-
H
E
Y
A
H
Q
W
F
G
N
L
V
S
P
E
W
W
E
Y
I
W
L
N
E
G
F
A
T
L
Y
E
F
Y
A
L
D
M
A
Y
P
G
Q
-
E
--
Y
W
E
L
F
N
Q
--
Q
V
I
Q
Y
-
A
M
G
-------------
Q
D
G
Q
A
S
T
R
P
M
---
N
W
N
---
A
A
T
P
G
E
I
S
A
L
F
D
R
V
A
Y
D
K
S
G
S
V
L
N
M
M
R
H
V
L
G
D
D
N
W
K
A
G
L
K
A
Y
L
T
D
R
A
L
Q
G
A
V
D
E
Q
L
Y
A
G
L
Q
S
A
I
EGKGVLP
N
---------------------------
G
--------
V
T
V
A
Q
I
M
R
T
W
T
N
E
A
G
Y
P
V
L
N
V
R
R
S
Y
D
T
G
D
V
I
I
S
Q
E
R
F
Y
N
D
R
K
V
P
N
T
N
I
WM
I
-----
P
-
Y
N
Y
V
H
---
Q
A
K
A
D
F
----
N
E
F
-
D
D
F
--------
Q
W
L
A
T
K
A
------
A
R
------
I
E
----------------
T
T
V
----
P
A
---------------------------------
N
E
W
I
V
F
N
K
Q
Q
V
G
Y
Y
R
V
N
Y
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H
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W
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L
I
T
N
A
L
H
---
E
---
N
------------
W
A
S
IH
R
L
N
R
A
Q
-
L
I
D
D
A
Y
W
L
-----
A
R
S
G
R
L
-----
D
L
-
R
-
V
A
L
R
F
M
T
Y
L
R
---
N
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R
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P
W
T
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A
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V
A
L
T
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N
-
N
R
L
R
G
T
A
E
-------------
Y
----
H
N
F
L
I
F
V
D
A
L
I
E
DIYSL
L
T
I
--------
D
-----------
A
-----------
V
-
S
P
D
D
T
L
L
H
K
Y
L
V
Q
T
I
S
T
W
A
C
S
M
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Y
T
D
-
C
L
M
-
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T
A
A
L
L
K
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A
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G
-
T
G
P
-
A
---------
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-
V
T
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---
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-
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N
S
----
K
N
L
A
E
R
T
M
L
I
D
S
L
G
C
S
N
N
K
E
F
L
K
A
F
---
L
T
T
A
L
G
S
--
I
-
N
Y
R
A
D
E
R
R
R
V
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Q
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Y
--
S
G
-
G
----
R
---
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G
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----
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A
--
L
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E
F
L
--
M
D
P
A
L
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N
E
----
F
V
S
T
L
S
T
S
T
L
N
S
A
L
S
A
I
A
S
R
T
-
N
-
N
V
E
E
M
N
K
L
N
A
L
I
T
A
L
GSRVN
S
Q
-
T
-
A
A
N
L
R
T
T
A
Q
A
N
L
D
W
V
N
G
F
E
G
L
M
L
S
N
F
L
A
E
A
45
HHSearch
88.99
20%
-72
- C5 -
4WZ9
4
?
A:
[49-916]
--------------
P
T
T
S
I
P
I
H
Y
D
L
-----
H
L
R
T
E
I
H
R
---
N
E
R
T
F
T
G
T
V
G
I
Q
L
Q
V
V-
Q
-
A
T
D
K
L
V
M
------
H
----
N
R
G
L
V
M
S
S
----
A
K
V
S
----
S
---------
L
PNGVT
G
A
P
T
L
IG
D
----------
V
----
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Y
----
S
T
-
D
--
T
TF
E
H
I
T
F
T
-
S
P
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-
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L
Q
----
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G
---
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Y
----
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L
E
---
V
A
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L
A
--
T
--
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D
--
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V
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N
----
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--
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-
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Y
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A
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--
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ET
D
---
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--------
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---
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------
T
------
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V
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D
F
Q
L
R
L
S
-------------
G
A
Q
R
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V
---
R
P
N
A
F
N
E
---
A
T
F
A
L
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A
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K
I
L
K
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L
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D
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TY
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A
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D
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A
A
G
A
M
E
N
W
G
L
V
T
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R
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A
-
L
L
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F
--
N
P
A
V
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T
Y
R
G
--
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T
N
-
V
---
A
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T
I
A
-
H
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A
H
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P
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W
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A
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L
Y
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F
Y
A
L
D
M
A
Y
P
G
Q
-
E
--
Y
W
E
L
F
N
Q
--
Q
V
I
Q
Y
-
A
M
G
-------------
Q
D
G
Q
A
S
T
R
P
M
---
N
W
N
---
A
A
T
P
G
E
I
S
A
L
F
D
R
V
A
Y
D
K
S
G
S
V
L
N
M
M
R
H
V
L
G
D
D
N
W
K
A
G
L
K
A
Y
L
T
D
R
A
L
Q
G
A
V
D
E
Q
L
Y
A
G
L
Q
S
A
--------
I
EGKGVLPN-------------------
G
--------
V
T
V
A
Q
I
M
R
T
W
T
N
E
A
G
---
Y
P
V
L
N
V
R
R
S
Y
D
T
----
G
D
V
I
I
S
Q
E
R
F
Y
N
D
R
--------
K
-
V
P
N
T
N
---
I
W
M
I
P
Y
N
---
Y
V
H
-
Q
A
K
-----------
A
D
F
N
------
E
F
-------
D
D
F
Q
W
L
A
------
T
-
K
A
A
R
I
----
E
------------------------
T
T
V
-----
P
A
N
E
W
I
V
F
N
K
Q
Q
V
G
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Y
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V
N
Y
D
E
H
N
W
E
L
I
T
N
A
L
H
---
E
NWA
S
------------
I
H
R
---
L
N
R
A
Q
-
L
I
D
D
A
Y
W
L
-----
A
R
S
G
R
L
-----
D
L
-
R
-
V
A
L
R
F
M
-
T
Y
L
---
R
-
N
E
--
R
E
Y
A
P
W
T
A
A
N
V
A
L
T
--
Y
F
N
N
R
L
R
G
---
T
-------------
A
E
Y
H
N
F
L
I
F
V
D
A
-----
L
I
E
--------
D
IYSLLTID---
A
-----------
V
S
P
D
D
T
-----
L
L
H
K
Y
L
V
Q
T
I
S
T
W
A
C
S
M
G
Y
T
D
-
C
L
M
K
T
A
A
--
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L
K
A
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A
S
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T
--
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P
A
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H
P
D
I
A
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V
T
Y
C
-
Y
G
M
R
S
---
A
L
-
E
S
E
----
F
Q
Y
L
Y
R
K
M
M
N
S
----
K
N
L
A
E
R
T
M
L
I
D
S
L
G
C
S
N
N
K
E
F
L
K
A
F
---
L
T
T
A
L
G
S
---I
N
Y
R
A
D
E
R
R
R
V
V
Q
A
I
Y
S
G
G
R
T
G
V
---
D
----
A
L
----
I
E
--
F
L
M
D
P
A
L
V
--
N
E
F
V
S
----
T
L
S
T
-
S
--
T
L
N
S
A
L
S
A
I
A
S
R
T
-
N
N
V
E
E
-
M
N
K
L
N
A
L
I
T
A
------
L
G
---
S
R
V
N
S
Q
T
A
A
N
L
R
T
T
A
Q
--
A
N
L
D
W
V
N
G
F
E
G
-
44
HHSearch
88.87
19%
-65
- C5 -
4KX7
9
AMPE_HUMAN
A:
[19-869]
--------------
P
D
F
V
N
P
V
H
Y
D
L
-----
H
V
K
P
L
L
E
-----
E
D
T
Y
T
G
T
V
S
I
S
I
N
L
S-
A
-
P
T
R
Y
L
W
L
------
H
----
L
R
E
T
R
I
T
R
----
L
P
E
L
K
R
PS
G
---------
D
------------
Q
----------
V
----
Q
V
R
R
C
F
E
Y
K
K
--
Q
--
E
Y
V
V
V
E
-
A
E
E
-
E
L
T
P
SSG
D
G
---
L
Y
----
L
L
T
---
M
E
F
A
G
W
L
N
--
G
--
S
L
--
V
G
F
Y
R
T
T
--
Y
T
E
----
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--
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K
S
I
A
A
--
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-
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H
--
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K
-
E
--
Y
-
G
A
L
S
N
M
P
V
A
---
K
E
E
S
VDDK---
W
--------
T
---
R
------
T
------
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
A
V
H
Q
F
D
S
V
K
R
I
S
-----
N
S
-
G
--
K
P
L
T
I
Y
V
---
Q
P
E
Q
K
H
T
---
A
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Y
A
A
N
I
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K
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F
D
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F
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Y
F
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M
N
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S
--
L
P
K
L
D
K
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A
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P
D
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G
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-
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--
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---
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L
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S
F
F
E
F
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G
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N
H
A
E
T
D
W
-
Q
--
M
R
D
Q
M
L
L
--
E
D
V
L
P
-
V
Q
E
-------------
D
D
S
L
M
S
S
H
P
I
---
I
V
T
---
V
T
T
P
D
E
I
T
S
V
F
D
G
I
S
Y
S
K
G
S
S
I
L
R
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L
E
D
W
I
K
P
E
N
F
Q
K
G
C
Q
M
Y
L
E
K
Y
Q
F
K
N
A
K
T
S
D
F
W
A
A
L
E
E
A
--------
S
---------------------------
R
--------
L
P
V
K
E
V
M
D
T
W
T
R
Q
M
G
---
Y
P
V
L
N
V
N
G
V
---------
K
N
I
T
Q
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R
F
L
L
D
P
RANPSQP-
P
-
S
D
L
G
Y
---
T
W
N
I
P
V
K
---
W
T
E
-
D
N
I
------------
T
------------------
S
S
V
L
F
N
------
R
S
E
K
E
G
I
----
T
L
N----------------
S
--------------
G
N
A
F
L
K
I
N
P
D
H
I
G
F
Y
R
V
N
Y
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V
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I
A
T
A
L
S
L
NH
K
---
T
------------
F
S
S
---
A
D
R
A
S
-
L
I
D
D
A
F
A
L
-----
A
R
A
Q
L
L
-----
D
Y
-
K
-
V
A
L
N
L
T
-
K
Y
L
---
K
-
R
E
--
E
N
F
L
P
W
Q
R
V
I
S
A
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T
--
Y
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I
S
M
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E
D
---
D
---
K
---------
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P
M
I
E
E
Y
F
Q
G
-----
Q
V
K
--------
P
-----------
I
A
D
S
L
GW-----
N
-
D
A
G
D
-----
H
V
T
K
L
L
R
S
S
V
L
G
F
A
C
K
M
G
D
R
E
-
A
L
N
N
A
S
S
--
L
F
E
Q
W
L
N
-
G
--
T
V
S
L
P
V
N
L
R
L
L
V
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-
Y
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M
Q
N
---
S
G
N
E
I
S
----
W
N
Y
T
L
E
Q
Y
Q
K
T
----
S
L
A
Q
E
K
E
K
L
L
Y
G
L
A
S
V
K
N
V
T
L
L
S
R
Y
---
L
D
L
L
K
D
T
--
N
-
L
I
K
T
Q
D
V
F
T
V
I
R
Y
I
S
Y
-
N
S
Y
G
K
---
N
----
M
A
----
W
N
--
W
I
Q
L
N
--
W
--
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Y
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V
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----
R
Y
T
L
N
N
-
R
N
L
G
R
I
V
T
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I
A
E
P
F
-
N
T
E
L
Q
-
L
W
Q
M
E
S
F
F
A
K
------
Y
P
-
Q
-
A
G
A
G
E
K
P
R
E
Q
V
L
E
T
V
K
--
N
N
I
E
W
L
K
Q
H
R
N
-
49
HHSearch
86.97
17%
-58
- C5 -
4X2U
12
AMP1_PLAFQ
A:
[9-847]
------------
Y
K
P
S
G
F
I
I
N
Q
V
T
L
-----
N
I
N
I
H
D
Q
-----
E
T
I
V
R
S
V
L
D
M
D
I
S
K
H-
N
-
V
G
E
D
L
V
F
------
D
----
G
V
G
L
K
I
N
E
----
I
S
I
N
----
N
---------
K
------------
K
----------
L
V
E
GE
E
Y
----
T
Y
-
D
--
N
--
E
--
F
L
T
-
I
F
SK
F
V
P
----
K
S
---
K
F
A
F
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S
E
V
I
---
I
H
P
E
T
N
----
Y
--
A
L
--
T
G
L
Y
K
--------------
S
--
K
N
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V
--
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Y
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---
N
E
F
E
I
P
GG---
R
--------
H
---
G
------
A
------
R
F
N
D
P
P
L
K
P
C
Y
L
F
A
V
V
A
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--
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S
---
E
E
K
Y
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---
L
Q
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K
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L
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L
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A
V
S
D
F
N
V
G
A
M
E
N
K
G
L
N
I
F
N
A
N
S
-
L
L
-
A
--
S
K
K
N
S
I
D
F
S
--
Y
A
R
-
I
---
L
T
V
V
G
-
H
E
Y
F
H
Q
Y
T
G
N
R
V
T
L
R
D
W
F
Q
L
T
L
K
E
G
L
T
V
H
R
E
N
L
F
S
E
E
M
T
K
T
V
-
T
--
T
R
L
S
H
V
D
--
L
L
R
S
V
-
Q
F
L
-------------
E
D
S
S
P
L
S
H
P
I
---
R
P
E
---
S
--
Y
V
S
M
E
N
F
Y
T
T
T
V
Y
D
K
G
S
E
V
M
R
M
Y
L
T
I
L
G
E
E
Y
Y
K
K
G
F
D
I
Y
I
K
K
N
D
G
N
T
A
T
C
E
D
F
N
Y
A
M
E
Q
A
--------
Y
---------------------------
K
M
K
K
ADNS-
A
N
L
N
Q
Y
L
-
L
W
F
S
Q
S
G
---
T
P
H
V
S
F
K
Y
N
Y
D
A
E
K
K
--
Q
Y
S
I
H
V
N
Q
Y
T
K
P
D
--------
E
N
Q
K
E
K
K
---
P
L
F
I
P
I
S
---
V
G
L
-
I
N
P
---------
E
N
G
K
E
M
------
I
S
-------
Q
T
T
L
E
L
T
------
K
-
E
S
D
T
F
----
V
F
N
NIA
V
K
P
I
P
SLFRGFSA
P
VYIED
Q
L
T
-----
D
E
E
R
I
L
L
L
K
Y
D
S
D
A
F
V
R
Y
N
S
C
T
N
I
Y
M
K
Q
I
L
M
N
Y
---
N
---
E
F
L
K
A
K
N
E
KLE
S
F
Q
L
T
---
P
V
N
A
Q
-
F
I
D
A
I
K
Y
L
L
E
DPH
A
D
A
G
F
K
-----
S
Y
-
I
-
V
S
L
P
Q
D
-
R
Y
I
---
I
-
N
F
--
V
S
N
L
D
T
D
V
L
A
D
T
K
E
--
Y
I
Y
K
Q
I
G
D
-----------------
K
L
N
D
V
Y
Y
K
M
F
K
S
-----
L
E
A
--------
K
ADDLTYFNDES
H
-----------
V
-
D
F
D
Q
-----
M
N
M
R
T
L
R
N
T
L
L
S
L
L
S
K
A
Q
Y
P
N
-
I
L
N
E
I
I
E
--
H
S
K
S
P
Y
P
----
S
N
W
-
L
T
S
L
S
V
S
A
Y
F
-
D
-------
K
Y
-
F
E
L
----
Y
D
K
T
Y
K
L
S
K
D
D
----
E
L
L
L
Q
E
W
--
L
K
T
V
S
R
S
D
R
K
D
I
Y
E
I
L
K
K
L
E
N
E
V
-
L
K
--
D
-
S
K
N
P
N
D
I
R
A
V
Y
L
P
F
T
N
-
N
L
R
R
F
---
H
----
D
I
SG
K
G
Y
K
--
L
I
A
E
V
--
I
--
T
K
T
D
K
----
F
N
P
----
M
V
A
T
Q
L
C
E
P
---------------------------------------------------------------
68
Fugue
86.82
18%
-52
- C5 -
3B34
14
AMPN_ECOLI
A:
[26-891]
---
P
Q
A
K
Y
R
H
D
-
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
-----
T
F
D
L
D
-----
A
Q
K
T
V
V
T
A
V
S
Q
A
V
R
H
G
--
A
-
S
D
A
P
L
R
L
------
N
----
G
E
D
L
K
L
V
S
----
V
H
I
N
----
D
---------
E
------------
P
----------
W
----
T
-
A
---
W
K
-
E
--
E
--
E
-
G
A
L
V
-
I
S
--
N
L
P
----
E
----
R
F
----
T
L
K
---
I
I
N
E
I
S
P
A
--
A
--
N
T
AL
E
G
L
Y
Q
S
----------------
G
D
A
L
C
--
T
-
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
DK
I
K
-
Y
--
P
-
F
L
L
S
N
G
N
R
V
---
A
Q
G
E
L
E
NG---
R
--------
H
---
W
------
V
------
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
-
T
-
T
R
S
G
R
E
--
V
A
L
E
L
Y
V
---
D
R
G
N
L
D
R
---
A
P
W
A
M
T
S
L
K
N
S
M
K
W
D
E
E
R
F
G
L
E
Y
D
--
L
D
I
Y
M
I
V
A
V
D
F
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
S
-
K
-
Y
V
-
L
AR
T
D
T
A
-
T
D
K
D
--
Y
L
D
-
I
---
E
R
V
I
G
-
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
S
D
L
G
S
R
A
-
V
--
N
R
I
N
N
V
R
--
T
M
R
G
L
-
Q
F
A
-------------
E
D
A
S
P
M
A
H
P
I
---
R
P
D
-----
M
V
I
E
M
N
N
F
Y
T
L
T
V
Y
E
K
G
A
E
V
I
R
M
I
H
T
L
L
G
E
E
N
F
Q
K
G
M
Q
L
Y
F
E
R
H
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
E
D
A
--------
S
---------------------------
N
--------
V
D
L
S
H
F
-
R
R
W
Y
S
Q
S
G
---
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
S
Q
R
T
P
A
T
P
D
--------
Q
-
A
E
K
Q
P
L
HI
P
F
A
I
E
L
----
Y
D
N
-
E
G
K
V
I
P
L
Q
K
GG
H
P
V
N
S
V
L
------
N
V
------
T
Q
A
E
Q
T
F
V
F
D
NVYF
Q
-
P
V
P
A
L
LCEF
S
A
-----------------
P
-----
V
K
L
E
Y
KWS
D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
S
R
W
D
A
A
Q
S
L
L
A
T
Y
I
K
L
N
V
---
A
---
R
------------
H
Q
Q
---
G
Q
P
L
S
-
L
P
V
H
V
A
D
A
-----
F
R
A
V
L
L
-----
D
E
-
K
-
I
D
P
A
L
A
A
E
I
L
---
T
-
L
P
--
S
V
N
E
M
A
E
L
F
--
D
I
I
-
D
P
I
A
I
A
E
V
R
---
E
---
A
L
--
T
R
----
T
L
A
T
E
L
A
D
E
L
L
A
-----
I
Y
N
--------
A
-----------
N
-----------
Y
-
Q
S
E
----------
Y
R
V
E
H
E
D
I
A
K
R
T
L
-
R
N
A
-
C
L
R
F
L
A
F
G
E
T
H
L
-
A
D
V
-
L
--
V
S
K
Q
F
H
E
A
N
N
M
T
D
A
-
L
A
A
L
S
---
A
A
-
V
A
A
Q
L
P
C
R
D
A
L
M
Q
E
Y
D
D
K
WHQN
G
L
V
M
D
K
W
F
I
L
Q
A
T
S
P
A
A
N
V
L
E
T
V
R
G
---
L
L
Q
H
R
S
F
--
T
-
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
--
G
S
-
N
P
---
A
---
A
F
H
----
A
E
DG
S
G
Y
L
F
--
L
--
V
E
M
L
T
----
D
L
N
S
R
N
P
Q
V
A
S
R
L
I
E
P
L
I
R
L
K
-
R
Y
D
A
K
R
Q
E
K
M
R
A
A
L
E
Q
------
L
K
-
G
-
L
E
N
L
S
G
D
L
Y
E
K
I
T
K
A
L
--
A
-----------
50
HHSearch
84.57
18%
-64
- C5 -
3B34
14
AMPN_ECOLI
A:
[34-850]
------------
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
-----
T
F
D
L
D
A
-------
Q
K
T
V
V
T
A
V
S
Q
A
V
R
HG
A
-
S
D
A
P
L
R
L
------
N
----
G
E
D
L
K
L
V
S
----
V
H
I
N
----
D
---------
E
------------
P
W---------
T
----
A
W
----
K
E
-
E
--
E
--
G
--
A
L
V
-
I
S
--
N
L
-----
P
E---
R
F
----
T
L
K
---
I
I
N
E
I
S
P
A
AN
T
--
A
L
--
E
G
L
Y
Q
S
----------------
G
D
A
L
C
--
T
-
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
--
D
K
-
I
KY
P
-
F
L
L
S
N
G
N
R
V
---
A
Q
G
E
L
E
NG---
R
--------
H
---
W
------
V
------
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
T
T
-
R
S
G
R
-
E
--
V
A
L
E
L
Y
V
---
D
R
G
N
L
D
R
---
A
P
W
A
M
T
S
L
K
N
S
M
K
W
D
E
E
R
F
G
L
E
Y
D
--
L
D
I
Y
M
I
V
A
V
D
F
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
S
K
Y
-
V
L
-
A
--
R
T
D
T
A
T
D
K
D
--
Y
L
D
-
I
---
E
R
V
I
G
-
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
S
D
L
G
S
R
-----
A
V
N
R
I
N
N
V
R
T
M
R
G
L
-
Q
F
A
-------------
E
D
A
S
P
M
A
H
P
I
---
R
P
D
---
M
--
V
I
E
M
N
N
F
Y
T
L
T
V
Y
E
K
G
A
E
V
I
R
M
I
H
T
L
L
G
E
E
N
F
Q
K
G
M
Q
L
Y
F
E
R
H
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
E
D
A
--------
S
---------------------------
N
--------
V
D
L
S
H
F
-
R
R
W
Y
S
Q
S
G
---
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
S
Q
R
T
P
A
T
P
D
----------
Q
A
E
K
Q
---
P
L
H
I
P
F
A
I
E
L
Y
D
N
-
E
G
-------------
K
V
I
------
P
L
Q
K
GG
H
P
V
N
S
V
L
N
V
T
------
Q
-
A
E
Q
T
F
----
V
F
-----------------------
D
N
V
-----
Y
F
Q
P
V
P
A
L
L
C
E
F
S
A
P
V
K
L
E
Y
K
-
W
S
D
Q
Q
L
T
F
L
M
R
---
H
ARN
D
------------
F
S
R
---
W
D
A
A
Q
S
L
L
A
T
Y
I
K
L
-----
N
V
A
R
H
Q
Q
GQ
P
L
S
L
-
P
V
H
V
A
D
A
F
R
A
V
L
L
DE
K
-
I
D
--
P
A
L
A
A
E
I
L
T
L
P
S
V
N
--
E
M
A
E
L
F
D
I
---
I
---
D
P
I
A
I
A
----
E
V
R
E
A
L
T
R
T
L
A
T
-----
E
L
A
D
E
L
L
A
I
Y
N
A
-----------
N
YQSEYR-----
V
-
E
H
E
D
-----
I
A
K
R
T
L
R
N
A
C
L
R
F
L
A
F
G
E
T
H
L
-
A
D
V
L
V
S
K
--
Q
F
H
E
A
N
---------
N
M
T
D
A
L
A
A
L
S
-
A
A
V
A
A
QLP
C
R
-
D
A
L
----
M
Q
E
Y
D
D
K
W
H
Q
N
----
G
L
V
M
D
K
W
F
I
L
Q
A
T
S
P
A
--
A
N
V
L
E
T
V
---
R
G
L
L
Q
H
R
SF
T
-
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
G
S
N
P
A
A
F
---
H
AED
G
S
G
----
Y
L
--
F
L
V
E
M
--
L
--
T
D
L
N
-------
S
-
R
N
P
Q
V
A
S
R
L
I
E
P
---------------------------------------------------------------
22
PsiBlast_CBE
84.52
35%
-87
- C5 -
1Z5H
4
TRF3_THEAC
B:
[1-420]
-----------------
M
E
V
E
K
Y
D
L
-----
T
L
D
F
D
-----
I
Q
K
R
T
F
N
G
T
E
T
I
T
A
D
A
------
G
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
T
---
Y
D
-
G
--
Q
--
T
-
V
R
A
P
-----
G
D
S
----
Q
----
P
Q
----
K
I
E
---
I
S
F
A
G
K
V
S
--
D
--
S
L
--
S
G
I
Y
-
Y
A
--
G
R
E
----
N
--
G
----
M
I
T
--
T
-
H
F
E
A
T
D
A
R
R
M
F
P
C
V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
Y
-
D
A
I
S
N
M
P
P
K
RIE
V
S
E
--------
R
--------
K
---
V
------
V
------
E
F
Q
D
T
P
R
M
S
T
Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
-
R
-
D
-------
I
D
L
I
L
------
A
S
L
K
D
--
I
R
S
K
Y
P
L
D
M
A
R
K
S
V
E
F
Y
E
N
Y
F
G
I
P
Y
A
--
L
P
K
M
H
L
I
S
V
P
E
F
G
A
G
A
M
E
N
W
G
A
I
T
F
R
E
-
I
-
Y
M
-
D
--
I
A
E
N
-
S
A
V
T
--
V
K
R
-
N
---
S
A
N
V
I
A
H
E
I
A
H
Q
W
F
G
D
L
V
T
M
K
W
W
N
D
L
W
L
N
E
S
F
A
T
F
M
S
--
Y
K
T
M
D
T
L
F
P
-
E
WS
F
W
G
D
F
F
V
--
S
R
T
S
G
-
A
L
R
-------------
S
D
S
L
K
N
T
H
P
I
---
E
V
D
---
V
R
D
P
D
E
I
S
Q
I
F
D
E
I
S
Y
G
K
G
A
S
I
L
R
M
I
E
D
Y
A
G
Y
E
E
F
R
K
G
I
S
K
Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
P
V
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
84.36
18%
-62
- C5 -
5DLL
18
?
A:
[17-826]
-------------
Y
L
K
D
Y
K
P
S
N
Y
L
I
D
E
T
H
L
I
F
E
L
D
E
S
-----
K
T
R
V
T
A
N
L
Y
I
V
A
N
R
E-
N
R
E
N
N
T
L
V
L
------
D
----
G
V
E
L
K
L
L
S
----
I
K
L
N
----
N
---------
K
------------
H
L
S
P-------
A
----
E
F
----
A
V
-
N
--
E
--
N
Q
L
I
I
N
N
V
P
E-
K
F
V
----
L
----
Q
T
----
V
V
E
---
I
N
P
S
A
N
----
T
--
S
L
--
E
G
L
Y
K
S
----------------
G
D
V
F
S
--
T
-
Q
C
E
A
T
G
F
R
K
I
T
Y
Y
L
D
R
P
D
V
M
A
A
F
T
V
K
I
I
A
--
D
K
K
K
--
Y
P
I
I
L
S
N
G
D
K
I
---
D
S
G
D
I
S
D
N
---
Q
--------
H
---
F
------
A
------
V
W
K
D
P
F
K
K
P
C
Y
L
F
A
L
V
A
G
D
L
A
S
I
K
D
T
Y
I
T
-
K
S
Q
R
-
K
--
V
S
L
E
I
Y
A
---
F
K
Q
D
I
D
K
---
C
H
Y
A
M
Q
A
V
K
D
S
M
K
W
D
E
D
R
F
G
L
E
Y
D
--
L
D
T
F
M
I
V
A
V
P
D
F
N
A
G
A
M
E
N
K
G
L
N
I
F
N
T
K
Y
-
I
M
-
A
--
S
N
K
T
A
T
D
K
D
--
F
E
L
-
V
---
Q
S
V
V
G
-
H
E
Y
F
H
N
W
T
G
D
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
T
S
D
L
N
S
R
D
-
V
K
-
R
I
D
D
V
R
---
I
I
R
S
A
-
Q
F
A
-------------
E
D
A
S
P
M
S
H
P
I
---
R
P
E
-----
S
Y
I
E
M
N
N
F
Y
T
V
T
V
Y
N
K
G
A
E
I
I
R
M
I
H
T
L
L
G
E
E
G
F
Q
K
G
M
K
L
Y
F
E
R
H
D
G
Q
A
V
T
C
D
D
F
V
N
A
M
A
D
A
--------
N
---------------------------
N
--------
R
D
F
S
-
L
F
K
R
W
Y
A
Q
S
G
---
T
P
N
I
K
V
S
E
N
Y
D
A
S
S
Q
T
Y
S
L
T
L
E
Q
T
T
L
P
T
A
D
----------
Q
K
E
K
Q
---
A
L
H
I
P
V
K
---
M
G
L
I
N
P
E
-----------
G
K
--------
N
I
------
A
E
Q
V
I
E
L
K
------
E
-
Q
K
Q
T
Y
----
T
F
-----------------
E
-----
N
I
A
-----
A
K
P
V
A
S
L
F
R
-
D
F
S
A
P
V
K
V
E
H
K
-
R
S
E
K
D
L
L
H
I
V
K
---
Y
---
D
------------
N
N
A
---
F
N
R
W
D
-
S
L
Q
Q
I
A
T
N
-----
I
I
L
N
N
A
-----
D
L
N
D
-
E
F
L
N
A
F
K
S
I
L
---
H
D
K
D
--
L
D
K
A
L
I
S
N
A
L
L
I
P
I
E
S
T
I
A
E
A
M
R
V
IM
V
D
D
I
V
L
S
--
R
K
N
V
V
N
Q
L
A
D
K
L
K
D
D
W
L
A
-----
V
Y
Q
--------
Q
-----------
C
NDNKPYS----
L
-
S
A
E
Q
-----
I
A
K
R
K
L
K
G
V
C
L
S
Y
L
M
N
A
S
D
Q
K
V
G
T
D
L
A
Q
Q
--
L
F
D
-
N
A
D
--------
N
M
T
D
Q
Q
T
A
F
T
-
E
L
L
K
S
---
N
D
K
Q
V
R
-
D
N
A
I
N
E
F
Y
N
R
W
R
H
E
----
D
L
V
V
N
K
W
L
L
S
Q
A
Q
I
S
H
E
S
A
--
L
D
I
V
---
K
G
L
V
N
H
P
AY
N
-
P
K
N
P
N
K
V
Y
S
L
I
G
G
F
G
A
-
N
F
L
Q
Y
H
CK
D
---
G
L
G
----
Y
A
--
F
M
A
D
T
--
V
--
L
A
L
D
K
----
F
N
----
H
Q
V
A
A
R
M
A
R
N
---------------------------------------------------------------
2
PsiBlast_PDB
84.18
35%
-86
- C5 -
1Z1W
2
TRF3_THEAC
A:
[1-420]
-----------------
M
E
V
E
K
Y
D
L
-----
T
L
D
F
D
-----
I
Q
K
R
T
F
N
G
T
E
T
I
T
A
D
A
------
G
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
T
---
Y
D
-
G
--
Q
--
T
-
V
R
A
P
-----
G
D
S
----
Q
----
P
Q
----
K
I
E
---
I
S
F
A
G
K
V
S
--
D
--
S
L
--
S
G
I
Y
-
Y
A
--
G
R
E
----
N
--
G
----
M
I
T
--
T
-
H
F
E
A
T
D
A
R
R
M
F
P
C
V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
Y
-
D
A
I
S
N
M
P
P
K
R
I
E
V
S
E
--------
R
--------
K
---
V
------
V
------
E
F
Q
D
T
P
R
M
S
T
Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
-
R
-
D
-------
I
D
L
I
L
------
A
S
L
K
D
--
I
R
S
K
Y
P
L
D
M
A
R
K
S
V
E
F
Y
E
N
Y
F
G
I
P
Y
A
--
L
P
K
M
H
L
I
S
V
P
E
F
G
A
G
A
M
E
N
W
G
A
I
T
F
R
E
-
I
-
Y
M
-
D
--
I
A
E
N
-
S
A
V
T
--
V
K
R
-
N
---
S
A
N
V
I
A
H
E
I
A
H
Q
W
F
G
D
L
V
T
M
K
W
W
N
D
L
W
L
N
E
S
F
A
T
F
M
S
--
Y
K
T
M
D
T
L
F
P
-
E
WS
F
W
G
D
F
F
V
--
S
R
T
S
G
-
A
L
R
-------------
S
D
S
L
K
N
T
H
P
I
---
E
V
D
---
V
R
D
P
D
E
I
S
Q
I
F
D
E
I
S
Y
G
K
G
A
S
I
L
R
M
I
E
D
Y
A
G
Y
E
E
F
R
K
G
I
S
K
Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
P
V
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.78
35%
-87
- C5 -
3Q7J
1
TRF3_THEAC
B:
[1-420]
-----------------
M
E
V
E
K
Y
D
L
-----
T
L
D
F
D
-----
I
Q
K
R
T
F
N
G
T
E
T
I
T
A
D
A
------
G
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
T
---
Y
D
-
G
--
Q
--
T
-
V
R
A
P
-----
G
D
S
----
Q
----
P
Q
----
K
I
E
---
I
S
F
A
G
K
V
S
--
D
--
S
L
--
S
G
I
Y
-
Y
A
--
G
R
E
----
N
--
G
----
M
I
T
--
T
-
H
F
Q
A
T
D
A
R
R
M
F
P
C
V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
Y
-
D
A
I
S
N
M
P
P
K
RIE
V
S
E
--------
R
--------
K
---
V
------
V
------
E
F
Q
D
T
P
R
M
S
T
Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
-
R
-
D
-------
I
D
L
I
L
------
A
S
L
K
D
--
I
R
S
K
Y
P
L
D
M
A
R
K
S
V
E
F
Y
E
N
Y
F
G
I
P
Y
A
--
L
P
K
M
H
L
I
S
V
P
E
F
G
A
G
A
M
E
N
W
G
A
I
T
F
R
E
-
I
-
Y
M
-
D
--
I
A
E
N
-
S
A
V
T
--
V
K
R
-
N
---
S
A
T
V
I
A
H
E
I
A
H
Q
W
F
G
D
L
V
T
M
K
W
W
N
D
L
W
L
N
E
S
F
A
T
F
M
S
--
Y
K
T
M
D
T
L
F
P
-
E
WS
F
W
G
D
F
F
V
--
S
R
T
S
G
-
A
L
R
-------------
S
D
S
L
K
N
T
H
P
I
---
E
V
D
---
V
R
D
P
D
E
I
S
Q
I
F
D
E
I
S
Y
G
K
G
A
S
I
L
R
M
I
E
D
Y
A
G
Y
E
E
F
R
K
G
I
S
K
Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
P
V
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.67
35%
-86
- C5 -
1Z5H
5
TRF3_THEAC
A:
[1-420]
-----------------
M
E
V
E
K
Y
D
L
-----
T
L
D
F
D
-----
I
Q
K
R
T
F
N
G
T
E
T
I
T
A
D
A
------
G
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
T
---
Y
D
-
G
--
Q
--
T
-
V
R
A
P
-----
G
D
S
----
Q
----
P
Q
----
K
I
E
---
I
S
F
A
G
K
V
S
--
D
--
S
L
--
S
G
I
Y
-
Y
A
--
G
R
E
----
N
--
G
----
M
I
T
--
T
-
H
F
E
A
T
D
A
R
R
M
F
P
C
V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
Y
-
D
A
I
S
N
M
P
P
K
R
I
E
V
S
E
--------
R
--------
K
---
V
------
V
------
E
F
Q
D
T
P
R
M
S
T
Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
-
R
-
D
-------
I
D
L
I
L
------
A
S
L
K
D
--
I
R
S
K
Y
P
L
D
M
A
R
K
S
V
E
F
Y
E
N
Y
F
G
I
P
Y
A
--
L
P
K
M
H
L
I
S
V
P
E
F
G
A
G
A
M
E
N
W
G
A
I
T
F
R
E
-
I
-
Y
M
-
D
--
I
A
E
N
-
S
A
V
T
--
V
K
R
-
N
---
S
A
N
V
I
A
H
E
I
A
H
Q
W
F
G
D
L
V
T
M
K
W
W
N
D
L
W
L
N
E
S
F
A
T
F
M
S
--
Y
K
T
M
D
T
L
F
P
-
E
WS
F
W
G
D
F
F
V
--
S
R
T
S
G
-
A
L
R
-------------
S
D
S
L
K
N
T
H
P
I
---
E
V
D
---
V
R
D
P
D
E
I
S
Q
I
F
D
E
I
S
Y
G
K
G
A
S
I
L
R
M
I
E
D
Y
A
G
Y
E
E
F
R
K
G
I
S
K
Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
P
V
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.23
35%
-84
- C5 -
3Q7J
2
TRF3_THEAC
A:
[1-420]
-----------------
M
E
V
E
K
Y
D
L
-----
T
L
D
F
D
-----
I
Q
K
R
T
F
N
G
T
E
T
I
T
A
D
A
------
G
D
I
V
L
------
D
----
A
V
G
L
Q
I
N
W
----
M
K
V
N
----
G
---------
R
------------
D
----------
T
----
A
F
T
---
Y
D
-
G
--
Q
--
T
-
V
R
A
P
-----
G
D
S
----
Q
----
P
Q
----
K
I
E
---
I
S
F
A
G
K
V
S
--
D
--
S
L
--
S
G
I
Y
-
Y
A
--
G
R
E
----
N
--
G
----
M
I
T
--
T
-
H
F
Q
A
T
D
A
R
R
M
F
P
C
V
D
H
P
A
Y
K
A
V
F
A
I
T
V
V
I
--
D
K
-
D
--
Y
-
D
A
I
S
N
M
P
P
K
R
I
E
V
S
E
--------
R
--------
K
---
V
------
V
------
E
F
Q
D
T
P
R
M
S
T
Y
L
L
Y
V
G
I
G
K
F
R
Y
E
Y
E
K
Y
-
R
-
D
-------
I
D
L
I
L
------
A
S
L
K
D
--
I
R
S
K
Y
P
L
D
M
A
R
K
S
V
E
F
Y
E
N
Y
F
G
I
P
Y
A
--
L
P
K
M
H
L
I
S
V
P
E
F
G
A
G
A
M
E
N
W
G
A
I
T
F
R
E
-
I
-
Y
M
-
D
--
I
A
E
N
-
S
A
V
T
--
V
K
R
-
N
---
S
A
T
V
I
A
H
E
I
A
H
Q
W
F
G
D
L
V
T
M
K
W
W
N
D
L
W
L
N
E
S
F
A
T
F
M
S
--
Y
K
T
M
D
T
L
F
P
-
E
WS
F
W
G
D
F
F
V
--
S
R
T
S
G
-
A
L
R
-------------
S
D
S
L
K
N
T
H
P
I
---
E
V
D
---
V
R
D
P
D
E
I
S
Q
I
F
D
E
I
S
Y
G
K
G
A
S
I
L
R
M
I
E
D
Y
A
G
Y
E
E
F
R
K
G
I
S
K
Y
L
N
D
H
K
F
G
N
A
E
G
S
D
L
W
T
A
I
E
D
V
--------
S
---------------------------
G
--------
K
P
V
K
R
V
M
E
Y
W
I
K
N
P
G
---
Y
P
V
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
76.96
19%
-72
- C5 -
4QHP
12
?
A:
[12-572]
----------
K
D
Y
Q
T
P
A
Y
H
I
L
K
T
D
L
-----
H
F
D
I
N
E
P
-------
Q
T
V
V
K
S
R
L
T
V
E
P
Q-
R
-
V
G
E
P
L
V
L
------
D
----
G
S
-
A
K
L
L
S
----
V
K
I
N
----
G
---------
A
------------
A
----------
A
----
D
Y
----
V
L
-
E
--
G
--
E
--
T
L
T
-
I
A
G-
V
-
P
----
S
E
---
R
F
----
T
V
E
---
V
E
T
E
I
L
P
A
--
E
NK
S
L
--
M
G
L
Y
A
S
----------------
G
G
N
L
F
--
T
-
Q
C
E
P
E
G
F
R
K
I
T
F
Y
I
D
R
P
D
V
M
S
K
F
T
T
T
I
V
A
--
D
K
K
R
--
Y
P
V
L
L
S
N
G
N
K
I
---
D
G
G
E
F
SDG---
R
--------
H
---
W
------
V
------
K
W
E
D
P
F
S
K
P
S
Y
L
F
A
L
V
A
G
D
L
A
V
T
E
D
Y
F
T
T
-
M
S
G
R
-
N
--
V
K
I
E
F
Y
T
---
T
E
A
D
K
P
K
---
V
G
F
A
V
E
S
L
K
N
A
M
K
W
D
E
T
R
F
G
L
E
Y
D
--
L
D
I
F
M
V
V
A
V
G
D
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
T
K
F
-
V
L
-
A
--
D
S
R
T
A
T
D
T
D
--
F
E
G
-
I
---
E
S
V
V
G
-
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
G
D
R
A
S
R
A
V
R
--
R
I
E
N
I
R
---
L
L
R
Q
H
-
Q
F
P
-------------
E
D
A
G
P
T
A
H
P
V
---
R
P
A
-----
S
Y
E
E
M
N
N
F
Y
T
M
T
V
Y
E
K
G
A
E
V
V
R
M
Y
H
T
L
L
G
E
E
G
F
Q
K
G
M
K
L
Y
F
Q
R
H
D
G
Q
A
V
T
C
D
D
F
R
A
A
M
A
D
A
--------
N
---------------------------
G
--------
I
N
L
D
Q
F
-
A
L
W
Y
S
Q
A
G
---
T
P
V
L
E
A
E
G
R
L
K
N
--
N
I
F
E
L
T
V
K
Q
T
V
P
P
T
P
D
----------
M
T
D
K
Q
---
P
M
M
I
P
V
K
V
G
L
L
N
R
-
N
G
E
------------
A
V
A
F
D
Y
QGK
R
A
------
T
E
A
V
L
L
L
T
------
E
-
A
E
Q
T
F
----
L
L
-----------------------
E
G
V
-----
T
E
A
V
V
P
S
L
L
R
G
F
S
A
P
V
H
L
N
Y
P
Y
-
S
D
D
D
L
L
L
L
L
A
---
H
---
D
------------
S
D
A
---
F
T
R
W
E
-
A
A
Q
T
L
Y
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.21
31%
-85
- C5 -
3QNF
3
ERAP1_HUMAN
B:
[81-562]
--------------------------------------------
T
F
W
G
T
T
K
V
E
I
T
A
--
S
-
Q
P
T
S
T
I
I
L
H
S
H
HL
Q
----
I
S
R
A
T
L
R
K
------
L
S
----
E
---------
E
------------
P
----------
L
----
Q
V
L
---
E
H
-
P
--
R
--
Q
-
E
Q
I
A
-
L
----
L
A
----
P
----
E
P
----
L
L
V
G
L
P
Y
T
V
V
I
H
Y
A
G
-
N
--
L
S
--
E
T
F
H
G
F
Y
--
K
S
T
Y
R
T
K
E
--
G
--
E
L
R
I
L
A
S
T
-
Q
F
E
P
T
A
A
R
M
A
F
P
C
F
D
E
P
A
F
K
A
S
F
S
I
K
I
R
R
--
E
P
-
R
--
H
-
L
A
I
S
N
-
M
P
L
---
V
K
S
--------
V
--------
T
---
V
AEG
L
I
E
D
------
H
F
D
V
T
V
K
M
S
T
Y
L
V
A
F
I
I
S
D
F
E
S
V
S
K
---
I
-
T
K
S
G
----
V
K
V
S
V
Y
A
VPD
K
I
N
Q
A
D
Y
A
L
D
A
A
V
T
L
L
E
------
F
Y
E
D
Y
F
S
I
P
Y
P
--
L
P
K
Q
D
L
A
A
I
P
D
F
Q
S
G
A
M
E
N
W
G
L
T
T
Y
R
E
-
S
A
L
L
-
F
--
D
A
E
K
-
S
S
A
S
--
S
K
L
G
I
---
T
M
T
V
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
M
E
W
W
N
D
L
W
L
N
E
G
F
A
K
F
M
E
F
V
S
V
S
V
T
H
P
E
L
-
K
--
V
G
D
Y
F
----
F
G
K
C
F
D
A
M
E
-------------
V
D
A
L
N
S
S
H
P
V
---
S
T
P
---
V
E
N
P
-----
M
F
D
D
V
S
Y
D
K
G
A
C
I
L
N
M
L
R
E
Y
L
S
A
D
A
F
K
S
G
I
V
Q
Y
L
Q
K
H
S
Y
K
N
T
K
N
E
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.98
31%
-85
- C5 -
3QNF
4
ERAP1_HUMAN
C:
[81-564]
--------------------------------------------
T
F
W
G
T
T
K
V
E
I
T
A
--
S
-
Q
P
T
S
T
I
I
LHSHHL
Q
----
I
S
R
A
T
L
R
K
----
G
A
L
S
----
E
---------
E
------------
P
----------
L
----
Q
V
L
---
E
H
-
P
--
R
--
Q
-
E
Q
I
A
-
L
----
L
A
----
P
----
E
P
----
L
L
V
GLP
Y
T
V
V
I
H
Y
A
G-
N
--
L
S
--
E
T
F
H
G
F
Y
--
K
S
T
YRTK
E
--
G
--
E
L
R
I
L
AS
T
-
Q
F
E
P
T
A
A
R
M
A
F
P
C
F
D
E
P
A
F
K
A
S
F
S
I
K
I
R
R
--
E
P
-
R
--
H
-
L
A
I
S
N
-
M
P
L
---
V
K
S
--------
V
--------
T
---
V
AEGLIE
D
------
H
F
D
V
T
V
K
M
S
T
Y
L
V
A
F
I
I
S
D
F
E
S
V
S
K
---
I
-
T
K
S
G
----
V
K
V
S
V
Y
A
VPD
K
I
N
Q
A
D
Y
A
L
D
A
A
V
T
L
L
E
------
F
Y
E
D
Y
F
S
I
P
Y
P
--
L
P
K
Q
D
L
A
A
I
P
D
F
Q
S
G
A
M
E
N
W
G
L
T
T
Y
R
E
-
S
A
L
L
-
F
--
D
A
E
K
-
S
S
A
S
--
S
K
L
G
I
---
T
M
T
V
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
M
E
W
W
N
D
L
W
L
N
E
G
F
A
K
F
M
E
F
V
S
V
S
V
T
H
P
E
L
-
K
--
V
G
D
Y
F
----
F
G
K
C
F
D
A
M
E
-------------
V
D
A
L
N
S
S
H
P
V
---
S
T
P
---
V
E
N
P
--------
D
V
S
Y
D
K
G
A
C
I
L
N
M
L
R
E
Y
L
S
A
D
A
F
K
S
G
I
V
Q
Y
L
Q
K
H
S
Y
K
N
T
K
N
E
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.92
31%
-86
- C5 -
2YD0
8
ERAP1_HUMAN
A:
[30-466]
--------------------------------------------
T
F
W
G
T
T
K
V
E
I
T
A
--
S
-
Q
P
T
S
T
I
I
L
H
S
H
HL
Q
----
I
S
R
A
T
L
R
K
----
G
-
L
S
----
E
---------
E
------------
P
----------
L
----
Q
V
L
---
E
H
-
P
--
R
--
Q
-
E
Q
I
A
-
L
----
L
A
----
P
----
E
P
----
L
L
V
G
L
P
Y
T
V
V
I
H
Y
A
G
-
N
--
L
S
--
E
T
F
H
G
F
Y
--
K
S
T
Y
R
T
K
E
--
G
--
E
L
R
I
L
A
S
T
-
Q
F
E
P
T
A
A
R
M
A
F
P
C
F
D
E
P
A
F
K
A
S
F
S
I
K
I
R
R
--
E
P
-
R
--
H
-
L
A
I
S
N
-
M
P
L
---
V
K
S
--------
V
--------
T
---
V
AEG
L
I
E
D
------
H
F
D
V
T
V
K
M
S
T
Y
L
V
A
F
I
I
S
D
F
E
S
V
S
K
---
I
-
T
K
S
G
----
V
K
V
S
V
Y
A
V
PD
K
I
N
Q
A
D
Y
A
L
D
A
A
V
T
L
L
E
------
F
Y
E
D
Y
F
S
I
P
Y
P
--
L
P
K
Q
D
L
A
A
I
P
D
F
Q
S
G
A
M
E
N
W
G
L
T
T
Y
R
E
-
S
A
L
L
-
F
--
D
A
E
K
-
S
S
A
S
--
S
K
L
G
I
---
T
M
T
V
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
M
E
W
W
N
D
L
W
L
N
E
G
F
A
K
F
M
E
F
V
S
V
S
V
T
H
P
E
L
-
K
--
V
G
D
Y
F
----
F
G
K
C
F
D
A
M
E
-------------
V
D
A
L
N
S
S
H
P
V
---
S
T
P
---
V
E
N
P
A
Q
I
R
E
M
F
D
D
V
S
Y
D
K
G
A
C
I
L
N
M
L
R
E
Y
L
S
A
D
A
F
K
S
G
I
V
Q
Y
L
Q
K
H
S
Y
K
N
T
K
N
E
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.78
33%
-76
- C5 -
4FYT
9
AMPN_HUMAN
A:
[146-460]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
A
A
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
E
F
N
I
T
L
I
H
--
P
K
-
D
--
L
-
T
A
L
S
N
M
L
P
K
---
G
P
S
--------
T
P
LPEDPN
W
N
---
V
------
T
------
E
F
H
T
T
P
K
M
S
T
Y
L
L
A
F
I
V
S
E
F
-----
D
Y
-
V
-
E
K
Q
A
-
S
NG
V
L
I
R
I
W
A
---
R
P
S
A
I
A
A
-
G
H
G
D
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
G
H
Y
D
T
P
Y
P
--
L
P
K
S
D
Q
I
G
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
-
S
L
-
L
--
F
D
P
L
-
S
S
S
S
S
N
K
E
R
-
V
---
V
T
V
I
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
I
E
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
----
G
A
D
Y
A
-
E
P-
T
W
N
L
K
D
L
--
M
V
L
N
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
STP
A
S
E
---
I
N
T
P
A
Q
I
S
E
L
F
D
A
I
S
Y
S
K
G
A
S
V
L
R
M
L
S
S
F
L
S
E
D
V
F
K
Q
G
L
A
S
Y
L
H
T
F
A
Y
Q
N
T
I
Y
L
N
L
W
D
H
L
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.64
33%
-75
- C5 -
4FYS
8
AMPN_HUMAN
A:
[146-460]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
A
A
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
E
F
N
I
T
L
I
H
--
P
K
-
D
--
L
-
T
A
L
S
N
M
L
P
K
---
G
P
S
--------
T
PLPEDPN
W
N
---
V
------
T
------
E
F
H
T
T
P
K
M
S
T
Y
L
L
A
F
I
V
S
E
F
-----
D
Y
-
V
-
E
K
Q
A
-
S
NG
V
L
I
R
I
W
A
---
R
P
S
A
I
A
A
-
G
H
G
D
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
G
H
Y
D
T
P
Y
P
--
L
P
K
S
D
Q
I
G
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
-
S
L
-
L
--
F
D
P
L
-
S
S
S
S
S
N
K
E
R
-
V
---
V
T
V
I
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
I
E
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
----
G
A
D
Y
A
-
E
P-
T
W
N
L
K
D
L
--
M
V
L
N
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
STP
A
S
E
---
I
N
T
P
A
Q
I
S
E
L
F
D
A
I
S
Y
S
K
G
A
S
V
L
R
M
L
S
S
F
L
S
E
D
V
F
K
Q
G
L
A
S
Y
L
H
T
F
A
Y
Q
N
T
I
Y
L
N
L
W
D
H
L
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.32
33%
-78
- C5 -
4FYQ
9
AMPN_HUMAN
A:
[146-468]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
A
A
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
E
F
N
I
T
L
I
H
--
P
K
-
D
--
L
-
T
A
L
S
N
M
L
P
K
---
G
P
S
--------
T
P
LPEDPN
W
N
---
V
------
T
------
E
F
H
T
T
P
K
M
S
T
Y
L
L
A
F
I
V
S
E
F
-----
D
Y
-
V
-
E
K
Q
A
-
S
NG
V
L
I
R
I
W
A
---
R
P
S
A
I
A
A
-
G
H
G
D
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
G
H
Y
D
T
P
Y
P
--
L
P
K
S
D
Q
I
G
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
-
S
L
-
L
--
F
D
P
L
-
S
S
S
S
S
N
K
E
R
-
V
---
V
T
V
I
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
I
E
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
----
G
A
D
Y
A
-
E
P-
T
W
N
L
K
D
L
--
M
V
L
N
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
STP
A
S
E
---
I
N
T
P
A
Q
I
S
E
L
F
D
A
I
S
Y
S
K
G
A
S
V
L
R
M
L
S
S
F
L
S
E
D
V
F
K
Q
G
L
A
S
Y
L
H
T
F
A
Y
Q
N
T
I
Y
L
N
L
W
D
H
L
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.23
33%
-76
- C5 -
4FYR
9
AMPN_HUMAN
A:
[146-460]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
A
A
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
E
F
N
I
T
L
I
H
--
P
K
-
D
--
L
-
T
A
L
S
N
M
L
P
K
---
G
P
S
--------
T
P
LPEDPN
W
N
---
V
------
T
------
E
F
H
T
T
P
K
M
S
T
Y
L
L
A
F
I
V
S
E
F
-----
D
Y
-
V
-
E
K
Q
A
-
S
NG
V
L
I
R
I
W
A
---
R
P
S
A
I
A
A
-
G
H
G
D
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
G
H
Y
D
T
P
Y
P
--
L
P
K
S
D
Q
I
G
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
-
S
L
-
L
--
F
D
P
L
-
S
S
S
S
S
N
K
E
R
-
V
---
V
T
V
I
A
-
H
E
L
A
H
Q
W
F
G
N
L
V
T
I
E
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
----
G
A
D
Y
A
-
E
P-
T
W
N
L
K
D
L
--
M
V
L
N
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
STP
A
S
E
---
I
N
T
P
A
Q
I
S
E
L
F
D
A
I
S
Y
S
K
G
A
S
V
L
R
M
L
S
S
F
L
S
E
D
V
F
K
Q
G
L
A
S
Y
L
H
T
F
A
Y
Q
N
T
I
Y
L
N
L
W
D
H
L
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.43
33%
-73
- C5 -
4OU3
16
AMPN_PIG
A:
[143-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
--------
T
PLAEDPN
W
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
-----
A
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
A
L
L
-
F
--
D
P
Q
S
-
S
S
I
S
--
N
K
E
-
R
---
V
V
T
V
I
A
H
E
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
---
E
-
P
--
T
W
N
L
K
D
L
--
I
V
P
G
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
TTP
A
E
E
---
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.38
33%
-76
- C5 -
4NZ8
18
AMPN_PIG
A:
[142-456]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
--------
T
P
LAEDPN
W
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
-----
A
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
A
L
L
-
F
--
D
P
Q
S
-
S
S
I
S
--
N
K
E
-
R
---
V
V
T
V
I
A
H
E
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
---
E
-
P
--
T
W
N
L
K
D
L
--
I
V
P
G
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
TTP
A
E
E
---
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.35
33%
-75
- C5 -
4NAQ
18
AMPN_PIG
A:
[142-456]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
--------
T
PLAEDPN
W
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
-----
A
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
A
L
L
-
F
--
D
P
Q
S
-
S
S
I
S
--
N
K
E
-
R
---
V
V
T
V
I
A
H
Q
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
---
E
-
P
--
T
W
N
L
K
D
L
--
I
V
P
G
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
TTP
A
E
E
---
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.30
33%
-74
- C5 -
4FKK
9
AMPN_PIG
A:
[144-458]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
--------
T
PLAEDPN
W
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
-----
A
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
A
L
L
-
F
--
D
P
Q
S
-
S
S
I
S
--
N
K
E
-
R
---
V
V
T
V
I
A
H
E
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
---
E
-
P
--
T
W
N
L
K
D
L
--
I
V
P
G
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
TTP
A
E
E
---
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.30
33%
-75
- C5 -
4FKH
9
AMPN_PIG
A:
[144-458]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
--------
T
PLAEDPN
W
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
-----
A
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
A
L
L
-
F
--
D
P
Q
S
-
S
S
I
S
--
N
K
E
-
R
---
V
V
T
V
I
A
H
E
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
---
E
-
P
--
T
W
N
L
K
D
L
--
I
V
P
G
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
TTP
A
E
E
---
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.18
33%
-65
- C5 -
4KXC
4
AMPE_HUMAN
A:
[148-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
D
A
R
K
S
F
P
C
F
D
E
P
N
K
K
A
T
Y
T
I
S
I
T
H
--
P
K
-
E
--
Y
-
G
A
L
S
N
-
M
P
V
---
A
K
E
--------
E
--------
S
---
V
------
D
DK
W
T
R
T
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
A
V
H
Q
F
D
S
--
V
K
R
-
I
-
S
N
S
G
-
K
---
P
L
T
I
Y
V
---
Q
P
E
--
Q
K
-
H
T
A
E
Y
A
A
N
I
T
K
S
V
F
D
Y
F
E
E
Y
F
A
M
N
Y
S
--
L
P
K
L
D
K
I
A
I
P
D
F
G
T
G
A
M
E
N
W
G
L
I
T
Y
R
E
T
N
-
L
L
-
Y
--
D
P
K
E
-
S
A
S
S
--
N
Q
Q
-
R
---
V
A
T
V
V
A
H
E
L
V
H
Q
W
F
G
N
I
V
T
M
D
W
W
E
D
L
W
L
N
E
G
F
A
S
F
F
E
F
L
G
V
N
H
A
------------------
E
T
D
W
-
Q
M
R
DQMLLEDV
L
P
V
Q
E
D
D
S
L
M
S
S
H
P
I
---
I
V
T
---
V
T
T
P
D
E
I
T
S
V
F
D
G
I
S
Y
S
K
G
S
S
I
L
R
M
L
E
D
W
I
K
P
E
N
F
Q
K
G
C
Q
M
Y
L
E
K
Y
Q
F
K
N
A
K
T
S
D
F
W
A
A
L
E
E
A
--------
S
---------------------------
R
--------
L
P
V
K
E
V
M
D
T
W
T
R
Q
M
G
---
Y
P
V
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.13
33%
-75
- C5 -
4HOM
9
AMPN_PIG
A:
[143-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
M
Q
S
T
D
A
R
K
S
F
P
C
F
D
E
P
A
M
K
A
T
F
N
I
T
L
I
H
--
P
N
-
N
--
L
-
T
A
L
S
N
M
P
P
K
---
G
S
S
--------
T
PLAEDPN
W
S
---
V
------
T
------
E
F
E
T
T
P
V
M
S
T
Y
L
L
A
Y
I
V
S
E
F
Q
S
V
N
E
T
-----
A
Q
N
-
G
--
V
L
I
R
I
W
A
---
R
P
N
A
I
A
E
-
G
H
G
M
Y
A
L
N
V
T
G
P
I
L
N
F
F
A
N
H
Y
N
T
S
Y
P
--
L
P
K
S
D
Q
I
A
L
P
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
R
E
-
N
A
L
L
-
F
--
D
P
Q
S
-
S
S
I
S
--
N
K
E
-
R
---
V
V
T
V
I
A
H
E
L
A
H
Q
W
F
G
N
L
V
T
L
A
W
W
N
D
L
W
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
H
A
---
E
-
P
--
T
W
N
L
K
D
L
--
I
V
P
G
D
-
V
Y
R
V
M
A
----------
V
D
A
L
A
S
S
H
P
L
TTP
A
E
E
---
V
N
T
P
A
Q
I
S
E
M
F
D
S
I
S
Y
S
K
G
A
S
V
I
R
M
L
S
N
F
L
T
E
D
L
F
K
E
G
L
A
S
Y
L
H
A
F
A
Y
Q
N
T
T
Y
L
D
L
W
E
H
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.01
33%
-67
- C5 -
4KXD
5
AMPE_HUMAN
A:
[148-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
D
A
R
K
S
F
P
C
F
D
E
P
N
K
K
A
T
Y
T
I
S
I
T
H
--
P
K
-
E
--
Y
-
G
A
L
S
N
-
M
P
V
---
A
K
E
--------
E
--------
S
---
V
------
D
DK
W
T
R
T
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
A
V
H
Q
F
D
S
--
V
K
R
-
I
-
S
N
S
G
-
K
---
P
L
T
I
Y
V
---
Q
P
E
--
Q
K
-
H
T
A
E
Y
A
A
N
I
T
K
S
V
F
D
Y
F
E
E
Y
F
A
M
N
Y
S
--
L
P
K
L
D
K
I
A
I
P
D
F
G
T
G
A
M
E
N
W
G
L
I
T
Y
R
E
T
N
-
L
L
-
Y
--
D
P
K
E
-
S
A
S
S
--
N
Q
Q
-
R
---
V
A
T
V
V
A
H
E
L
V
H
Q
W
F
G
N
I
V
T
M
D
W
W
E
D
L
W
L
N
E
G
F
A
S
F
F
E
F
L
G
V
N
H
A
------------------
E
T
D
W
-
Q
M
R
DQMLLEDV
L
P
V
Q
E
D
D
S
L
M
S
S
H
P
I
---
I
V
T
---
V
T
T
P
D
E
I
T
S
V
F
D
G
I
S
Y
S
K
G
S
S
I
L
R
M
L
E
D
W
I
K
P
E
N
F
Q
K
G
C
Q
M
Y
L
E
K
Y
Q
F
K
N
A
K
T
S
D
F
W
A
A
L
E
E
A
--------
S
---------------------------
R
--------
L
P
V
K
E
V
M
D
T
W
T
R
Q
M
G
---
Y
P
V
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.80
33%
-68
- C5 -
4KXB
4
AMPE_HUMAN
A:
[148-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
D
A
R
K
S
F
P
C
F
D
E
P
N
K
K
A
T
Y
T
I
S
I
T
H
--
P
K
-
E
--
Y
-
G
A
L
S
N
-
M
P
V
---
A
K
E
--------
E
--------
S
---
V
------
D
DK
W
T
R
T
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
A
V
H
Q
F
D
S
--
V
K
R
-
I
-
S
N
S
G
-
K
---
P
L
T
I
Y
V
---
Q
P
E
--
Q
K
-
H
T
A
E
Y
A
A
N
I
T
K
S
V
F
D
Y
F
E
E
Y
F
A
M
N
Y
S
--
L
P
K
L
D
K
I
A
I
P
D
F
G
T
G
A
M
E
N
W
G
L
I
T
Y
R
E
T
N
-
L
L
-
Y
--
D
P
K
E
-
S
A
S
S
--
N
Q
Q
-
R
---
V
A
T
V
V
A
H
E
L
V
H
Q
W
F
G
N
I
V
T
M
D
W
W
E
D
L
W
L
N
E
G
F
A
S
F
F
E
F
L
G
V
N
H
A
------------------
E
T
D
W
-
Q
M
R
DQMLLEDV
L
P
V
Q
E
D
D
S
L
M
S
S
H
P
I
---
I
V
T
---
V
T
T
P
D
E
I
T
S
V
F
D
G
I
S
Y
S
K
G
S
S
I
L
R
M
L
E
D
W
I
K
P
E
N
F
Q
K
G
C
Q
M
Y
L
E
K
Y
Q
F
K
N
A
K
T
S
D
F
W
A
A
L
E
E
A
--------
S
---------------------------
R
--------
L
P
V
K
E
V
M
D
T
W
T
R
Q
M
G
---
Y
P
V
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.75
33%
-66
- C5 -
4KX9
4
AMPE_HUMAN
A:
[148-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
D
A
R
K
S
F
P
C
F
D
E
P
N
K
K
A
T
Y
T
I
S
I
T
H
--
P
K
-
E
--
Y
-
G
A
L
S
N
-
M
P
V
---
A
K
E
--------
E
--------
S
---
V
------
D
DK
W
T
R
T
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
A
V
H
Q
F
D
S
--
V
K
R
-
I
-
S
N
S
G
-
K
---
P
L
T
I
Y
V
---
Q
P
E
--
Q
K
-
H
T
A
E
Y
A
A
N
I
T
K
S
V
F
D
Y
F
E
E
Y
F
A
M
N
Y
S
--
L
P
K
L
D
K
I
A
I
P
D
F
G
T
G
A
M
E
N
W
G
L
I
T
Y
R
E
T
N
-
L
L
-
Y
--
D
P
K
E
-
S
A
S
S
--
N
Q
Q
-
R
---
V
A
T
V
V
A
H
E
L
V
H
Q
W
F
G
N
I
V
T
M
D
W
W
E
D
L
W
L
N
E
G
F
A
S
F
F
E
F
L
G
V
N
H
A
------------------
E
T
D
W
-
Q
M
R
DQMLLEDV
L
P
V
Q
E
D
D
S
L
M
S
S
H
P
I
---
I
V
T
---
V
T
T
P
D
E
I
T
S
V
F
D
G
I
S
Y
S
K
G
S
S
I
L
R
M
L
E
D
W
I
K
P
E
N
F
Q
K
G
C
Q
M
Y
L
E
K
Y
Q
F
K
N
A
K
T
S
D
F
W
A
A
L
E
E
A
--------
S
---------------------------
R
--------
L
P
V
K
E
V
M
D
T
W
T
R
Q
M
G
---
Y
P
V
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.69
33%
-67
- C5 -
4KXA
5
AMPE_HUMAN
A:
[148-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
D
A
R
K
S
F
P
C
F
D
E
P
N
K
K
A
T
Y
T
I
S
I
T
H
--
P
K
-
E
--
Y
-
G
A
L
S
N
-
M
P
V
---
A
K
E
--------
E
--------
S
---
V
------
D
DK
W
T
R
T
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
A
V
H
Q
F
D
S
--
V
K
R
-
I
-
S
N
S
G
-
K
---
P
L
T
I
Y
V
---
Q
P
E
--
Q
K
-
H
T
A
E
Y
A
A
N
I
T
K
S
V
F
D
Y
F
E
E
Y
F
A
M
N
Y
S
--
L
P
K
L
D
K
I
A
I
P
D
F
G
T
G
A
M
E
N
W
G
L
I
T
Y
R
E
T
N
-
L
L
-
Y
--
D
P
K
E
-
S
A
S
S
--
N
Q
Q
-
R
---
V
A
T
V
V
A
H
E
L
V
H
Q
W
F
G
N
I
V
T
M
D
W
W
E
D
L
W
L
N
E
G
F
A
S
F
F
E
F
L
G
V
N
H
A
------------------
E
T
D
W
-
Q
M
R
DQMLLEDV
L
P
V
Q
E
D
D
S
L
M
S
S
H
P
I
---
I
V
T
---
V
T
T
P
D
E
I
T
S
V
F
D
G
I
S
Y
S
K
G
S
S
I
L
R
M
L
E
D
W
I
K
P
E
N
F
Q
K
G
C
Q
M
Y
L
E
K
Y
Q
F
K
N
A
K
T
S
D
F
W
A
A
L
E
E
A
--------
S
---------------------------
R
--------
L
P
V
K
E
V
M
D
T
W
T
R
Q
M
G
---
Y
P
V
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.30
33%
-65
- C5 -
4KX8
5
AMPE_HUMAN
A:
[148-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
D
A
R
K
S
F
P
C
F
D
E
P
N
K
K
A
T
Y
T
I
S
I
T
H
--
P
K
-
E
--
Y
-
G
A
L
S
N
-
M
P
V
---
A
K
E
--------
E
--------
S
---
V
------
D
DK
W
T
R
T
T
F
E
K
S
V
P
M
S
T
Y
L
V
C
F
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-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------