@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2500c: (2016-05-11 )
MTTTTTTISGGILPKEYQDLRDTVADFARTVVAPVSAKHDAEHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEELGKVDQSVAITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFGLTEPGAGSDAGSTRTTARLEGDEWIINGSKQFITNSGTDITSLVTVTAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTFADARVPRENLLGARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVKYANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKPFKKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIGEGTTEVQLMLIARSLGLQ
Atome Classification :
(34 SA)
-----------.........10........20........30........40-.....-...50........60........70.---.---......80-........90........100...------....110.......120.......130.......140.......-150-...-.....160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.--------------......330.......340.......350.......360.......370.......380.......390..------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------M
T
T
T
T
T
T
ISGGIL
P
K
E
Y
Q
D
L
R
D
T
V
A
D
F
A
R
T
V
VAPVSAKHDA-EHS
F
P
-
Y
E
I
V
A
K
MGEMGLFGLPF
P
E
E
YGGMG
G
---
D
---
Y
F
A
L
S
L
V
L
-
E
E
L
GKVDQ
S
V
A
I
T
L
E
AAVGLGAM
P
------
I
Y
RFG
T
E
E
Q
K
Q
KWLPDLTSG
R
A
L
A
GFGLTEPGAGSDAGST
R
T
T
A
-
R
L--EGD-
E
W
I
INGS
K
Q
F
I
TNSGT
D
I
T
S
L
V
T
V
T
A
VTGTTGTAADAKK
E
I
S
T
I
I
VPSGTPG
F
T
V
E
P
V
Y
N
KVGWNASDTH
P
L
T
FADARV
P
R
E
N
LLGARGS
G
Y
A
N
F
L
S
I
L
DEG
R
I
A
I
A
A
LATGAAQ
G
C
V
D
E
S
V
K
Y
A
N
Q
R
Q
SFGQP
I
G
A
Y
Q
A
I
G
F
K
I
A
R
M
E
A
R
A
H
V
A
R
T
A
Y
Y
D
A
A
A
K
M
LAG--------------KPF
K
K
E
A
A
I
A
K
M
I
S
S
E
AAMDNSRDA
T
Q
I
HGGYGFMNEYP
V
A
R
HYRDS
K
V
L
EIGEG
T
T
E
V
Q
L
M
L
I
A
R
S
LGLQ------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
92.97
42%
-69
- C2 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
--------------
M
D
F
N
L
T
-----
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
-
K
G
I
Y
D
-
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
---
V
L
S
Y
I
L
A
V
-
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
------
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
-
T
K
--
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
--
A
D
I
Y
I
V
F
A
M
T
D
K
S
----
K
G
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
--------------
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.44
43%
-68
- C2 -
4L1F
5
?
B:
[5-377]
-----------------------
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
-
A
H
I
W
D
-
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
-
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
------
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
-
V
L
--
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
-
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
G
V
H
G
-----
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
--------------
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
91.99
43%
-66
- C2 -
4L1F
7
?
A:
[1-379]
-------------------
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
-
A
H
I
W
D
-
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
-
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
------
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
-
V
L
--
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
--
A
D
T
Y
V
V
F
A
M
T
D
K
----
S
Q
G
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
--------------
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.64
43%
-71
- C2 -
1JQI
4
ACADS_RAT
A:
[10-382]
-----------------------
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
-
E
H
L
F
P
-
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
L
A
Y
S
I
A
L
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
E
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
-----
A
S
A
T
V
V
F
A
S
T
D
R
S
R
Q
-
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
91.01
43%
-69
- C2 -
1JQI
4
ACADS_RAT
B:
[10-382]
-----------------------
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
-
E
H
L
F
P
-
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
L
A
Y
S
I
A
L
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
E
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
-----
A
S
A
T
V
V
F
A
S
T
D
R
S
R
Q
-
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.95
39%
-60
- C2 -
1UKW
2
?
A:
[5-376]
-----------------------
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
-
K
E
E
V
P
-
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
L
D
E
V
I
V
G
-
E
E
L
A
Y
A
C
M
G
I
-
Y
T
I
P
M
A
S
D
L
G
I
T
P
------
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
-
I
R
--
Q
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
--
A
E
W
V
V
V
F
A
----
T
V
N
P
E
L
R
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
--------------
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
---------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
90.89
42%
-71
- C2 -
1BUC
3
ACDS_MEGEL
B:
[10-381]
----------------------------
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
-
K
G
I
Y
D
-
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
L
S
Y
I
L
A
V
-
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
------
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
-
T
K
--
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
--
A
D
I
Y
I
V
F
A
M
T
D
K
S
----
K
G
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
--------------
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
90.75
39%
-61
- C2 -
1UKW
3
?
B:
[5-376]
-----------------------
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
-
K
E
E
V
P
-
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
L
D
E
V
I
V
G
-
E
E
L
A
Y
A
C
M
G
I
-
Y
T
I
P
M
A
S
D
L
G
I
T
P
------
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
-
I
R
--
Q
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
--
A
E
W
V
V
V
F
A
----
T
V
N
P
E
L
R
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
--------------
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
---------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.36
43%
-68
- C2 -
4L1F
7
?
A:
[5-377]
-----------------------
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
-
A
H
I
W
D
-
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
-
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
------
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
-
V
L
--
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
-
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
G
V
H
G
-----
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
--------------
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.31
42%
-69
- C2 -
1BUC
3
ACDS_MEGEL
A:
[10-381]
----------------------------
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
-
K
G
I
Y
D
-
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
L
S
Y
I
L
A
V
-
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
------
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
-
T
K
--
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
--
A
D
I
Y
I
V
F
A
M
T
D
K
S
----
K
G
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
--------------
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
89.66
42%
-66
- C2 -
2VIG
6
ACADS_HUMAN
B:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
-
E
H
L
F
P
-
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
------
A
S
A
A
V
V
F
A
S
T
-------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
89.34
42%
-67
- C2 -
2VIG
6
ACADS_HUMAN
D:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
-
E
H
L
F
P
-
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
------
A
S
A
A
V
V
F
A
S
T
D
-----
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.27
45%
-68
- C2 -
4U83
1
?
A:
[9-382]
----------------------
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
-
E
H
A
F
P
-
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
---
M
V
A
Y
A
L
A
L
-
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
------
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
--
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
-
S
G
K
N
-
G
N
V
V
I
V
F
A
V
T
----
D
P
A
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
--------------
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
---------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.00
42%
-65
- C2 -
2VIG
5
ACADS_HUMAN
A:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
-
E
H
L
F
P
-
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
------
A
S
A
A
V
V
F
A
S
T
D
R
A
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.92
45%
-67
- C2 -
4U83
1
?
C:
[9-382]
----------------------
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
-
E
H
A
F
P
-
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
---
M
V
A
Y
A
L
A
L
-
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
------
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
--
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
-
S
G
K
N
-
G
N
V
V
I
V
F
A
V
T
----
D
P
A
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
--------------
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
---------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
88.89
36%
-67
* C2 *
2JIF
9
ACDSB_HUMAN
A:
[24-402]
------------------
A
P
L
Q
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
-
N
S
K
M
E
-
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
---
F
L
S
T
V
L
V
I
-
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
------
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
K
--
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
--
A
G
L
F
L
V
M
A
N
V
D
P
----
T
I
G
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
--------------
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
-------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
88.59
42%
-66
- C2 -
2VIG
5
ACADS_HUMAN
E:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
-
E
H
L
F
P
-
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
------
A
S
A
A
V
V
F
A
S
T
D
R
A
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
88.46
42%
-67
- C2 -
2VIG
9
ACADS_HUMAN
F:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
-
E
H
L
F
P
-
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
------
A
S
A
A
V
V
F
A
S
T
D
------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
88.35
36%
-72
- C2 -
4KTO
4
?
A:
[28-408]
------------------
G
L
N
F
A
L
G
E
E
I
D
A
L
R
A
S
V
R
R
F
A
S
E
R
I
A
P
L
A
D
D
A
D
R
-
S
N
A
F
P
-
M
S
L
W
R
E
M
G
E
L
G
L
L
G
I
T
A
D
E
A
H
G
G
A
G
L
---
G
---
Y
L
A
H
C
V
A
M
-
E
E
I
S
R
A
S
A
S
V
G
L
S
Y
G
A
H
S
N
L
C
V
N
Q
------
I
N
R
N
G
K
P
A
Q
K
S
R
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
E
P
G
-----
V
S
M
K
L
K
A
-
D
K
--
R
G
D
-
R
Y
V
L
N
G
S
K
M
W
I
T
N
G
P
D
--
A
D
V
L
V
V
Y
A
K
T
D
P
-------
P
R
G
I
T
A
F
L
V
E
K
A
F
P
G
F
S
A
G
Q
K
L
D
K
L
G
M
R
G
S
N
T
S
E
L
I
F
T
D
C
E
V
P
E
E
N
V
L
G
G
V
G
E
G
V
K
V
L
M
S
G
L
D
Y
E
R
V
V
L
S
A
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
L
H
E
R
K
Q
F
G
Q
P
I
G
E
F
Q
L
M
Q
G
K
L
A
D
M
Y
V
T
M
N
A
A
R
A
Y
V
Y
A
V
A
A
A
C
D
R
G
--------------
E
T
A
R
K
D
A
A
G
C
I
L
Y
A
A
E
K
A
T
A
M
A
L
E
A
I
Q
A
L
G
G
N
G
Y
T
N
D
Y
P
A
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
F
A
E
------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
87.68
42%
-68
- C2 -
2VIG
5
ACADS_HUMAN
C:
[6-378]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
-
E
H
L
F
P
-
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
-
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
------
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
--
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
------
A
S
A
A
V
V
F
A
S
T
D
------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
--------------
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.37
43%
-69
- C2 -
4N5F
10
?
A:
[20-385]
------------------------------
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
-
D
A
H
L
P
-
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
---
Y
V
A
Y
A
L
A
M
-
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
------
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
-
E
L
--
R
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
--
A
G
V
A
I
V
F
A
M
T
D
P
E
A
----
G
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
--------------
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.96
39%
-68
- C2 -
2DVL
2
?
A:
[3-370]
-----------------------
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
-
K
A
E
Y
P
-
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
---
S
V
T
W
A
L
A
L
-
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
------
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
R
--
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
--
A
H
L
Y
V
V
M
A
R
T
---------
E
K
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
--------------
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
---------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
85.54
39%
-67
- C2 -
2DVL
2
?
B:
[3-370]
-----------------------
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
-
K
A
E
Y
P
-
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
---
S
V
T
W
A
L
A
L
-
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
------
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
R
--
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
--
A
H
L
Y
V
V
M
A
R
T
---------
E
K
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
--------------
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
---------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
85.22
40%
-67
- C2 -
2D29
2
?
B:
[20-383]
------------------------------------
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
-
T
G
A
F
P
-
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
R
L
F
A
R
M
V
-
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
------
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
--
E
G
G
--
W
R
L
N
G
T
K
Q
F
I
T
Q
G
--
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
P
P
S
P
E
R
K
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
--------------
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.75
40%
-64
- C2 -
2D29
2
?
A:
[20-383]
------------------------------------
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
-
T
G
A
F
P
-
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
R
L
F
A
R
M
V
-
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
------
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
--
E
G
G
--
W
R
L
N
G
T
K
Q
F
I
T
Q
G
--
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
P
P
S
P
E
R
K
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
--------------
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.48
43%
-70
- C2 -
4N5F
10
?
B:
[20-385]
------------------------------
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
-
D
A
H
L
P
-
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
---
Y
V
A
Y
A
L
A
M
-
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
------
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
-
E
L
--
R
D
---
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
--
A
G
V
A
I
V
F
A
M
T
D
P
E
A
----
G
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
--------------
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
124
Fugue
83.74
34%
-68
- C2 -
2Z1Q
2
?
B:
[5-577]
KKLWQKGGGWL
L
E
V
P
E
R
V
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
G
E
L
E
L
N
-
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
---
P
---
K
V
I
S
T
V
V
A
-
E
E
L
S
G
S
G
-
G
F
S
V
T
Y
G
A
H
T
S
I
G
T
L
P
------
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
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D
A
L
A
A
K
T
R
A
-
T
L
S
E
D
G
K
-
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
--
A
H
L
F
T
V
F
A
K
V
D
--------
G
E
H
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
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Y
A
T
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Q
F
G
R
P
I
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F
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L
I
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Q
K
L
G
E
M
A
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R
I
Y
A
A
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S
A
V
Y
R
T
V
G
L
I
D
E
A
L
LGKKG
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
AEPED
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
YGQGVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
R
I
Y
L
A
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A
L
D
R
A
Q
A
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A
L
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D
E
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V
Y
S
A
A
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L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR
79
PsiBlast_CBE
81.81
34%
-63
- C2 -
3MDE
3
ACADM_PIG
A:
[6-378]
-----------------------
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
E
Y
P
-
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
I
D
S
C
L
I
T
-
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
T
-
L
G
Q
V
P
------
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
K
--
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
---
D
P
D
P
K
A
P
A
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
--------------
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
81.63
37%
-69
- C2 -
2PG0
2
?
A:
[10-385]
-----------------------
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
-
R
G
I
I
P
-
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
----
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
-------
V
G
I
G
L
H
N
DIV
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
-
V
K
--
D
G
D
-
Y
Y
I
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N
G
Q
K
T
F
I
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N
G
---
I
H
A
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L
I
V
V
A
C
K
-
T
D
P
Q
A
K
P
P
H
R
G
I
S
L
L
V
V
E
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D
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P
G
F
T
R
G
R
K
L
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K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
--------------
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
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Y
E
I
A
R
R
Y
R
D
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P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
D
L
-------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
81.26
31%
-63
- C2 -
3SF6
16
?
A:
[25-398]
------------------
G
I
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
-
D
G
E
L
P
A
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L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
K
-
G
Y
G
C
A
G
M
---
S
---
A
V
A
Y
G
L
A
C
-
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
------
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
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P
D
H
G
S
D
P
A
G
M
R
T
R
A
-
T
R
--
S
G
D
-
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
--
A
D
V
A
V
V
W
A
R
T
D
E
---------
G
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
P
G
A
T
-
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
--------------
E
L
A
P
E
Q
V
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
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S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
-------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
81.11
34%
-61
- C2 -
3MDD
2
ACADM_PIG
A:
[6-378]
-----------------------
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
E
Y
P
-
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
I
D
S
C
L
I
T
-
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
T
-
L
G
Q
V
P
------
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
K
--
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
---
D
P
D
P
K
A
P
A
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
--------------
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
80.20
34%
-61
- C2 -
3MDE
4
ACADM_PIG
B:
[6-378]
-----------------------
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
E
Y
P
-
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
---
I
I
D
S
C
L
I
T
-
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
T
-
L
G
Q
V
P
------
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
K
--
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
---
D
P
D
P
K
A
P
A
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
--------------
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
80.09
37%
-68
- C2 -
2PG0
2
?
B:
[10-384]
-----------------------
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
-
R
G
I
I
P
-
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
----
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
-------
V
G
I
G
L
H
N
DIV
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
-
V
K
--
D
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
---
I
H
A
D
L
I
V
V
A
C
K
-
T
D
P
Q
A
K
P
P
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
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K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
--------------
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
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S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
D
--------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
79.82
34%
-60
- C2 -
3MDD
2
ACADM_PIG
B:
[6-378]
-----------------------
L
T
E
Q
Q
K
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---
G
---
I
I
D
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A
Y
G
C
T
G
V
Q
T
A
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A
N
T
-
L
G
Q
V
P
------
L
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N
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L
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---
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--------------
R
R
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-----------------------------------------------------------------------------------------------------------------------------------------------