@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2555c: (2016-05-11 )
MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFVPFFLGQRTPPYPTATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKRGAIELAWALLTNSLAAGGYGLDPERIWTTVYFDDDEAVRLWQEVAGLPAERIQRRGMADNYWSMGIPGPCGPSSEIYYDRGPEFGPAGGPIVSEDRYLEVWNLVFMQNERGEGTTKEDYQILGPLPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARVAARAYDVGNHEDDVRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAIVGDLMATVRNAMGPSYPELVADFERISRIAVAEETAFNRTLASGSRLFEEVASSTKKSGATVLSGSDAFTLHDTYGFPIELTLEMAAETGLQVDEIGFRELMAEQRRRAKADAAARKHAHADLSAYRELVDAGATEFTGFDELRSQARILGIFVDGKRVPVVAHGVAGGAGEGQRVELVLDRTPLYAESGGQIADEGTISGTGSSEAARAAVTDVQKIAKTLWVHRVNVESGEFVEGDTVIAAVDPGWRRGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGPLTDDQRTQVEEVTNEAVQADFEVRTFTEQLDKAKAMGAIALFGESYPDEVRVVEMGGPFSLELCGGTHVSNTAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLKVPSEEVPARVANLVERLRAAEKELERVRMASARAAATNAAAGAQRIGNVRLVAQRMSGGMTAADLRSLIGDIRGKLGSEPAVVALIAEGESQTVPYAVAANPAAQDLGIRANDLVKQLAVAVEGRGGGKADLAQGSGKNPTGIDAALDAVRSEIAVIARVG
Atome Classification :
(27 SA)
.........10........20.......-.30.........40........50.....-----....60----..-......----.----70........80........90...-----.....100.......110.......120.......130--------....---------...140.......150..-------.....160.......170.......180.--.......190.--......200...-....210..-.-....220.....----..230.......240.......250.......260-....-..--.270-----------------.---------------------------------------------.....---...280.-------------------------------------------------......290.......300.......310.......-320.--.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420...--....430.......440.......450-......---.460........470-.---........480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.....-..650.......-660.......-670........680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780....---...790.......800.......810.......820.......830......-.840.......850.......860.......870.......880.......890.......900..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
T
H
E
I
R
K
R
F
L
D
H
F
V
KAGHTEVPS
A
S
V
I
-LD-DP
N
L
L
F
VNA
G
M
V
Q
F
V
P
F
F
LG-QRTPP-----YP
T
A
T
-----
S
I
-
Q
K
C
IRT----P----DIDEVGITTRH
N
T
F
F
Q
MAGNFS
F
G
D
-----
Y
F
K
R
G
A
I
E
L
A
W
A
L
L
T
N
S
LAAGGYGL
D
P
E
R
I
W
T
T
V
Y
FDD--------
D
E
A
V
---------
R
L
W
Q
E
V
AGL
P
A
E
R
I
Q
RRG-------MADNYWSMGIPGPCGPSSEIYYDRGPE-F--GPAGGPIVSED--
R
Y
L
E
V
W
N
L
V
F
M
Q-NERGEGTTK-E-D
Y
Q
I
LGPLPRKN----IDTGM
G
V
E
R
I
A
L
V
L
Q
D
V
H
N
V
Y
E
T
D
L
L
R
P
V
I
D
T
V
A
R
-
V
A
A
R
-
A
Y--DV-------------------G---------------------------------------------NHED
D
---
V
R
Y
R
I
I
A-------------------------------------------------DHS
R
T
A
A
I
L
I
GDGVSPGND
G
R
G
Y
V
L
R
R
L
L
R
R
V
I
R
S
A
-
K
-LL--G
I
D
A
A
I
V
G
D
L
M
A
T
V
R
N
AMGPS
Y
P
E
L
V
A
D
F
E
R
I
S
R
I
AVAEETAFNRTL
A
S
G
S
R
L
F
E
E
V
A
S
STKKS
G
A
T
V
LSGS
D
A
F
T
L
HDTYG
F
P
I
E
L
T
L
E
M
A
A
ETGLQ
V
D
E
I
G
--
F
R
E
L
M
A
E
Q
R
R
R
AK
A
D
A
A
A
R
KHAHA
D
L
S
-
A
Y
R
E
L
V
---
D
AG-ATEFT
G
F
D
E
---
L
---
R
SQA
R
I
L
G
I
F
VDG
K
R
V
P
V
V
A
HGVAGGAGE
G
Q
R
V
E
L
V
L
DRTPLYAESGGQIADEGTISGTGS
S
E
A
A
R
A
A
V
T
D
V
Q
K
I
A
K
T
L
W
V
H
R
V
NVESG
E
F
VEG
D
T
V
I
A
AVDPGWRRGATQGHS
G
T
H
M
V
H
A
A
L
R
Q
VLGPNAVQAGSLNR
P
G
Y
L
R
F
D
F
NWQGPLTD
D
Q
R
T
Q
V
E
E
V
T
N
E
A
V
Q
ADF
E
V
R
-
T
F
T
E
Q
L
D
K
A
K
AM-
G
A
I
A
LFGESY-P-D
E
V
R
V
V
EMGG
P
F
S
L
E
LCGGTHVSNTAQIG
P
V
T
I
L
GESSI
G
S
G
V
R
R
V
E
A
Y
V
G
L
D
S
F
R
H
L
A
K
E
R
A
L
M
A
G
L
A
S
SLKV
P
S
E
E
V
P
A
R
V
A
N
L
V
E
R
L
R
A
A
E
K
E
L
E
R
V
R
M
ASARAAATNAAA
G
A
---
Q
R
IG
N
V
R
L
V
A
Q
R
MSGGM
T
A
A
D
L
R
S
L
I
G
D
I
R
G
KLGSE
P
A
V
V
A
L
I
AEGESQTV
P
-
Y
A
VAANPA
A
Q
DLGI
R
A
N
D
L
V
K
Q
L
A
V
AVEGRGGGK
A
D
LAQGSGKNPT
G
I
D
A
A
L
D
A
V
R
S
E
I
A
V
I
A
RVG
29
HHSearch
92.77
26%
-70
* C1 *
3WQY
1
SYA_ARCFU
A:
[60-904]
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
-
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
P
-----
A
N
P
L
T
-----
I
S
-
Q
P
C
I
R
L
----
D
----
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
------
L
G
V
K
K
E
D
I
V
-------------------------------------------
Y
----------
K
E
E
P
W
A
G
G
--
G
N
A
G
P
C
L
E
A
I
V
G
----------------------
G
L
E
V
A
T
L
V
F
M
N
-
L
E
E
H
P
E
G
D
I
E
I
-
K
G
A
R
Y
R
K
M
D
N
Y
I
----
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
-
N
S
N
V
-
S
F
--
N
R
E------------------
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
---
E
K
V
Y
S
L
A
-------------------------------------------------
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
--
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
---
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
DI
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
K
I
-----------
T
L
Q
---
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
---
P
TLL
E
F
E
A
E
V
I
G
V
E
---------------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
----
K
F
E
V
V
D
V
L
E
A
D
-
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
-
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
G
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
--
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
---
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
-
V
V
-
D
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
--
A
-
V
G
--
C
L
M
A
K
--
G
E
G
K
V
F
V
V
T
F
S
G
----
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
----
17
PsiBlast_PDB
89.70
24%
-68
- C1 -
3WQY
1
SYA_ARCFU
A:
[60-897]
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
-
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
-----
P
A
N
P
L
-----
T
I
S
Q
P
C
I
R
L
----
D
----
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
-
N
E
L
-----
G
V
K
K
E
D
I
---
V
Y
K
E
E
--------
P
------------------------------------------
W
A
G
G
--
G
N
A
G
P
C
L
E
------------
A
I
V
G
G
----------
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
------
D
I
E
I
K
G
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
-
N
S
N
V
-
S
F
---------------------------------------------------------------------
N
R
E
D
E
---
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
EL
G
L
D
---
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
---
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
K
K
K
-----
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
----
K
D
I
Y
A
E
---------
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
K
I
T
LQ
N
E
Y
P
-
A
T
E
K
L
Y
Y
D
D
PTL
L
---
E
F
E
A
E
V
I
G
V
-------------------
E
G
D
F
V
--
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
----
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
A
K
P
E
V
--
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
-
G
F
R
L
Y
Q
G
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
--
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
---
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
D
M
Q
A
------
L
Q
K
L
A
E
R
L
A
E
K
G
A
V
G
C
L
M
A
K
G
E
G
K
V
---
F
V
V
T
F
S
G
Q
K
Y
D
----
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
-----------
18
PsiBlast_PDB
88.76
24%
-71
- C1 -
3WQZ
2
SYA_ARCFU
A:
[60-897]
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
-
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
-----
P
A
N
P
L
-----
T
I
S
Q
P
C
I
R
L
----
D
----
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
-
N
E
L
-----
G
V
K
K
E
D
I
---
V
Y
K
E
E
--------
P
------------------------------------------
W
A
G
G
--
G
N
A
G
P
C
L
E
------------
A
I
V
G
G
----------
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
------
D
I
E
I
K
G
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
-
N
S
N
V
-
S
F
---------------------------------------------------------------------
N
R
E
D
E
---
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RGER
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
EL
G
L
D
---
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
---
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
K
K
K
-----
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
----
K
D
I
Y
A
E
---------
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
K
I
T
LQ
N
E
Y
P
-
A
T
E
K
L
Y
Y
D
D
PTL
L
---
E
F
E
A
E
V
I
G
V
-------------------
E
G
D
F
V
--
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
----
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
A
K
P
E
V
--
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
-
G
F
R
L
Y
Q
G
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
--
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
---
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
D
M
Q
A
------
L
Q
K
L
A
E
R
L
A
E
K
G
A
V
G
C
L
M
A
K
G
E
G
K
V
---
F
V
V
T
F
S
G
Q
K
Y
D
----
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
-----------
27
PsiBlast_CBE
86.89
45%
-81
- C1 -
3HXZ
6
SYA_ECOLI
B:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
WG
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.89
45%
-83
- C1 -
3HXX
3
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
---
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.86
45%
-82
- C1 -
3HY0
4
SYA_ECOLI
B:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
WG
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.81
45%
-81
- C1 -
3HXZ
6
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
86.75
45%
-81
- C1 -
3HXZ
4
SYA_ECOLI
C:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
WG
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
86.65
45%
-81
- C1 -
3HXZ
4
SYA_ECOLI
D:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
WG
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.61
45%
-83
- C1 -
3HXW
5
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
---
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.58
45%
-82
- C1 -
3HY0
4
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
86.47
46%
-83
- C1 -
3HY0
4
SYA_ECOLI
A:
[2-439]
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
-
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
-
F
N
R
Q
A
--------
D
G
T
M
E
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
A
-
T
D
-----------------------------------------------------------------------
L
S
N
---
K
S
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.46
45%
-83
- C1 -
3HXU
5
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
---
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.13
45%
-84
- C1 -
3HXY
5
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
---
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.08
45%
-79
- C1 -
3HY1
4
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
---
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.08
45%
-82
- C1 -
3HXV
6
SYA_ECOLI
A:
[4-436]
--
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
-
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
R
A
T
-----
T
S
-
Q
R
C
V
R
A
GGKH
N
----
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
---
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
E
A
Y
---------
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPY
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
-
I
W
G
G
P
P
G
S
P
E
E
D
G
D
--
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
---------
P
L
P
K
P
S
----
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
-
V
T
G
--
A
T
--
D
L
-------------------
S
---------------------------------------------
N
K
S
-------
L
R
V
I
A
-------------------------------------------------
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
--
K
L
S
G
D
T
-
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.19
45%
-81
- C1 -
1YFR
3
SYA_AQUAE
A:
[3-449]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
-
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
R
A
T
-----
S
C
-
Q
K
C
L
R
V
----
S
GKHN
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
L
K
-----
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
E
A
Y
---------
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
-------
E
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
-
Y
--
E
-------
G
D
E
--
R
Y
L
E
I
W
N
L
V
F
M
Q
-
Y
N
R
D
E
N
G
--------
V
L
T
P
L
P
H
P
N
----
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
-
V
S
G
K
-
K
Y
--
G
--------------------
E
---------------------------------------------
K
F
E
T
D
---
V
A
L
R
V
I
A
-------------------------------------------------
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
------
A
R
K
H
------P
V
Y
S
H
L
K
---
E
L
G
-
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.05
45%
-85
- C1 -
1YFS
1
SYA_AQUAE
B:
[3-449]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
-
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
R
A
T
-----
S
C
-
Q
K
C
L
R
V
----
S
GKHN
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
L
K
-----
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
E
A
Y
---------
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
-------
E
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
-
Y
--
E
-------
G
D
E
--
R
Y
L
E
I
W
N
L
V
F
M
Q
-
Y
N
R
D
E
N
G
--------
V
L
T
P
L
P
H
P
N
----
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
-
V
S
G
K
-
K
Y
--
G
--------------------
E
---------------------------------------------
K
F
E
T
D
---
V
A
L
R
V
I
A
-------------------------------------------------
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
------
A
R
K
H
------P
V
Y
S
H
L
K
---
E
L
G
-
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
84.77
28%
-70
- C1 -
2ZTG
3
SYA_ARCFU
A:
[60-739]
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
-
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
P
-----
A
N
P
L
T
-----
I
S
-
Q
P
C
I
R
L
----
D
----
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
------
L
G
V
K
K
E
D
I
V
-------------------------------------------
Y
----------
K
E
E
P
W
A
G
G
--
G
N
A
G
P
C
L
E
A
I
V
G
----------------------
G
L
E
V
A
T
L
V
F
M
N
-
L
E
E
H
P
E
G
D
I
-
E
I
K
G
A
R
Y
R
K
M
D
N
Y
I
----
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
-
N
S
N
V
-
S
F
--
N
R
ED
E
R
V
R
R
I
V
A
E
S
S
K
L
A
GIM
G
ELRGERL
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
------------------
I
V
V
P
L
---
E
K
V
Y
S
L
A
-------------------------------------------------
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
--
E
L
G
-
L
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
---
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D-
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
----
I
-------
T
L
Q
---
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
---
P
TLL
E
F
E
A
E
V
I
G
V
E
---------------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
----
K
F
E
V
V
D
V
L
E
A
D
-
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
-
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
G
G
V
P
P
G
-
R
K
I
R
V
V
Q
V
G
D
--
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.77
45%
-83
- C1 -
1YFT
1
SYA_AQUAE
A:
[3-449]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
-
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
R
A
T
-----
S
C
-
Q
K
C
L
R
V
----
S
GKHN
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
L
K
-----
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
E
A
Y
---------
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
-------
E
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
-
Y
--
E
-------
G
D
E
--
R
Y
L
E
I
W
N
L
V
F
M
Q
-
Y
N
R
D
E
N
G
--------
V
L
T
P
L
P
H
P
N
----
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
-
V
S
G
K
-
K
Y
--
G
--------------------
E
---------------------------------------------
K
F
E
T
D
---
V
A
L
R
V
I
A
-------------------------------------------------
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
------
A
R
K
H
------P
V
Y
S
H
L
K
---
E
L
G
-
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.53
45%
-84
- C1 -
1YFS
1
SYA_AQUAE
A:
[3-449]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
-
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
R
A
T
-----
S
C
-
Q
K
C
L
R
V
----
S
GKHN
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
L
K
-----
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
E
A
Y
---------
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
-------
E
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
-
Y
--
E
-------
G
D
E
--
R
Y
L
E
I
W
N
L
V
F
M
Q
-
Y
N
R
D
E
N
G
--------
V
L
T
P
L
P
H
P
N
----
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
-
V
S
G
K
-
K
Y
--
G
--------------------
E
---------------------------------------------
K
F
E
T
D
---
V
A
L
R
V
I
A
-------------------------------------------------
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
------
A
R
K
H
------P
V
Y
S
H
L
K
---
E
L
G
-
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.58
45%
-87
- C1 -
1YGB
1
SYA_AQUAE
A:
[3-449]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
-
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
R
A
T
-----
S
C
-
Q
K
C
L
R
V
----
S
GKHN
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
L
K
-----
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
E
A
Y
---------
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
-------
E
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
-
Y
--
E
-------
G
D
E
--
R
Y
L
E
I
W
N
L
V
F
M
Q
-
Y
N
R
D
E
N
G
--------
V
L
T
P
L
P
H
P
N
----
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
-
V
S
G
K
-
K
Y
--
G
--------------------
E
---------------------------------------------
K
F
E
T
D
---
V
A
L
R
V
I
A
-------------------------------------------------
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
------
A
R
K
H
------P
V
Y
S
H
L
K
---
E
L
G
-
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.27
45%
-80
- C1 -
1YFR
4
SYA_AQUAE
B:
[3-449]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
-
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
R
A
T
-----
S
C
-
Q
K
C
L
R
V
----
S
GKHN
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
L
K
-----
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
E
A
Y
---------
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
-------
E
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
-
Y
--
E
-------
G
D
E
--
R
Y
L
E
I
W
N
L
V
F
M
Q
-
Y
N
R
D
E
N
G
--------
V
L
T
P
L
P
H
P
N
----
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
-
V
S
G
K
-
K
Y
--
G
--------------------
E
---------------------------------------------
K
F
E
T
D
---
V
A
L
R
V
I
A
-------------------------------------------------
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
------
A
R
K
H
------P
V
Y
S
H
L
K
---
E
L
G
-
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.84
42%
-88
- C1 -
4XEO
6
SYAC_HUMAN
A:
[29-408]
----
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
-
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
-----
H
P
M
A
K
LS
R
A
A
N
T
-
Q
K
C
I
R
A
GGKH
N
-----
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
-----
F
G
I
P
I
E
R
L
Y
V
T
-
Y
F
G
G
--------
D
E
A
A
GLEAD
L
E
C
K
Q
I
W
Q
N
L
-
G
L
D
D
T
K
I
L
P
G
N
-------
M
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
I
G
-----
G
R
D
A
A
H
L
V
N
Q
D
DP
N
V
L
E
I
W
N
L
V
F
I
Q
-
Y
N
R
-------
E
-
A
D
G
I
L
K
P
L
P
K
K
S
----
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
G
A
R
-
P
Y
TG
K
V
-------------------
G
---------------------------------------------
A
E
D
A
D
G
I
D
M
A
Y
R
V
L
A
-------------------------------------------------
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
-
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
L
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
74.50
42%
-84
- C1 -
4XEM
6
?
A:
[25-404]
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
-
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
HPMAK
L
S
R
A
A
-----
N
T
-
Q
K
C
I
R
A
G--------
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
-----
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
EAAGLEAD
L
E
C
K
---------
Q
I
W
Q
N
-
L
G
L
D
D
T
K
I
L
P
G
N
-------
M
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
I
G
G
-
R
--
D
A
A
H
L
V
N
Q
D
D
P
--
N
V
L
E
I
W
N
L
V
F
I
Q
-
Y
N
R
E
A
--------
D
G
I
L
K
P
L
P
K
K
S
----
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
-
G
T
G
A
R
P
Y
--
T
G
KVGAE--------------
D
---------------------------------------------
A
D
G
I
D
---
M
A
Y
R
V
L
A
-------------------------------------------------
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
-
H
E
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.40
42%
-88
- C1 -
4XEM
6
?
A:
[29-404]
----
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
-
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
-----
H
P
M
A
K
LS
R
A
A
N
T
-
Q
K
C
I
R
A
G--------
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
-----
F
G
I
P
I
E
R
L
Y
V
T
-
Y
F
G
G
--------
D
E
A
A
GLEAD
L
E
C
K
Q
I
W
Q
N
L
-
G
L
D
D
T
K
I
L
P
G
N
-------
M
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
I
G
-----
G
R
D
A
A
H
L
V
N
Q
D
DP
N
V
L
E
I
W
N
L
V
F
I
Q
-
Y
N
R
-------
E
-
A
D
G
I
L
K
P
L
P
K
K
S
----
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
G
A
R
-
P
Y
TG
K
V
-------------------
G
---------------------------------------------
A
E
D
A
D
G
I
D
M
A
Y
R
V
L
A
-------------------------------------------------
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
H
E
-
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.22
42%
-90
- C1 -
4XEO
8
SYAC_HUMAN
B:
[29-405]
----
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
-
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
-----
H
P
M
A
K
LS
R
A
A
N
T
-
Q
K
C
I
R
A
---------
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
-----
F
G
I
P
I
E
R
L
Y
V
T
-
Y
F
G
G
--------
D
E
A
A
GLEAD
L
E
C
K
Q
I
W
Q
N
L
-
G
L
D
D
T
K
I
L
P
G
N
-------
M
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
I
G
-----
G
R
D
A
A
H
L
V
N
Q
D
DP
N
V
L
E
I
W
N
L
V
F
I
Q
-
Y
N
R
-------
E
-
A
D
G
I
L
K
P
L
P
K
K
S
----
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
G
A
R
-
P
Y
TG
K
V
-------------------
G
---------------------------------------------
A
E
D
A
D
G
I
D
M
A
Y
R
V
L
A
-------------------------------------------------
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
-
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------