@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2592c: (2016-05-12 )
MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGADAGAEIARRSRGTPRIANRLLRRVRDFAEVRADGVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEAATVEEVCEPFLVRAGMVARTPRGRVATALAWTHLGMTPPVGASQPGLFE
Atome Classification :
(20 SA)
.........10........20........-30........40........50-------........60........70........80.---------.--...------------------------...90.-----..---------------------------------.----.--------------------------.----..100.-.------.-----....110.......120.------......130.......140.......150.......160..-----------..---...170......-.180.......190.......200-........---210.....-..220.-......230.......240.......250...-----..---..260.......270.......280........290---------........300.......310.......320.......330.......340..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTERSDRDVSP
A
L
T
VGEG
D
I
D
V
S
LR
P
R
S
L
-
R
E
F
IGQ
P
R
V
R
E
Q
L
Q
L
V
I
EGAKN-------RGGTP
D
H
I
L
LSGPPGLG
K
T
S
L
A
M
I
I
A
A
ELGS---------
S
--
L
RV------------------------TSGP
A
L
-----
E
R---------------------------------A----
G
--------------------------
D
----
L
A
A
M
L
S
-
N
------
L
-----
V
E
H
D
V
L
F
I
D
E
I
H
R
I
AR
P
A
------
E
E
M
L
Y
L
A
M
E
D
F
R
V
D
V
V
V
GKGPGATSI
P
L
EVA
P
F
T
L
V
GATTR-----------SG---ALTGP
L
R
DRFGF-TAHMDFY
E
P
A
E
L
E
R
V
L
A
RSA
G
I
L
--
G
I
E
LGADA---
G
A
E
I
A
R
RS-RGT
P
R
I
-
A
N
R
L
L
R
R
V
R
D
F
A
E
V
RADGV
I
T
R
D
V
A
K
A
A
L
E
VY-----
D
V
---
D
E
L
G
L
D
R
L
D
R
A
V
L
S
A
L
T
R
SFGGG-P
V
G
V
S
T
L
A
V
AV----------GEEAA
T
V
E
E
V
C
E
P
F
L
V
RAGMVARTPRG
R
V
A
T
A
L
A
W
T
HLGMTPPVGASQPGLFE
2
PsiBlast_PDB
94.15
56%
-115
* C1 *
1IXS
1
RUVB_THET8
B:
[4-318]
---------------------
L
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
---------
N
--
L
R
V
------------------------
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
--------------------------
D
----
L
A
A
I
L
A
-
N
S-----
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
Q
A
------
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
G
---
L
I
T
A
P
L
L
S
R
F
G
I
-
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
--
G
V
R
I
T
E
E
A
---
A
L
E
I
G
R
R
S
-
R
G
T
M
R
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-----
G
L
---
D
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
-
P
V
G
L
A
T
L
A
T
A
L
----------
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
A
T
E
L
A
Y
R
H
L
G
Y
P
P
P
V
---------
21
PsiBlast_CBE
93.72
56%
-115
- C1 -
1HQC
2
RUVB_THET8
B:
[5-318]
----------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
---------
N
--
L
R
V
------------------------
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
--------------------------
D
----
L
A
A
I
L
A
-
N
S-----
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
Q
A
------
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
G
---
L
I
T
A
P
L
L
S
R
F
G
I
-
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
--
G
V
R
I
T
E
E
A
---
A
L
E
I
G
R
R
S
-
R
G
T
M
R
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-----
G
L
---
D
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
-
P
V
G
L
A
T
L
A
T
A
L
----------
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
P
P
P
V
---------
9
PsiBlast_PDB
93.24
50%
-115
- C1 -
1J7K
4
RUVB_THEMA
A:
[19-329]
-----------------------
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
I
------------
I
D
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
G
---
L
L
S
S
P
L
R
S
R
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
G
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
85
Fugue
92.71
56%
-113
- C1 -
1HQC
2
RUVB_THET8
A:
[5-318]
----------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
---------
N
--
L
R
V
------------------------
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
--------------------------
D
----
L
A
A
I
L
A
-
N
S-----
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
Q
A
------
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
G
---
L
I
T
A
P
L
L
S
R
F
G
I
-
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
--
G
V
R
I
T
E
E
A
---
A
L
E
I
G
R
R
S
-
R
G
T
M
R
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-----
G
L
---
D
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
-
P
V
G
L
A
T
L
A
T
A
L
----------
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
P
P
P
V
---------
1
PsiBlast_PDB
92.71
56%
-113
- C1 -
1HQC
2
RUVB_THET8
A:
[5-318]
----------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
---------
N
--
L
R
V
------------------------
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
--------------------------
D
----
L
A
A
I
L
A
-
N
S-----
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
Q
A
------
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
G
---
L
I
T
A
P
L
L
S
R
F
G
I
-
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
--
G
V
R
I
T
E
E
A
---
A
L
E
I
G
R
R
S
-
R
G
T
M
R
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-----
G
L
---
D
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
-
P
V
G
L
A
T
L
A
T
A
L
----------
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
P
P
P
V
---------
94
HHSearch
92.45
56%
-112
- C1 -
1HQC
2
RUVB_THET8
A:
[5-318]
----------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
---------
N
--
L
R
V
------------------------
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
--------------------------
D
----
L
A
A
I
L
A
N
S
------
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
Q
A
------
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
G
---
L
I
T
A
P
L
L
S
R
F
G
I
-
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
--
G
V
R
I
T
E
E
A
---
A
L
E
I
G
R
R
S
-
R
G
T
M
R
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-----
G
L
---
D
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
-
P
V
G
L
A
T
L
A
T
A
L
----------
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
P
P
P
V
---------
5
PsiBlast_PDB
92.25
50%
-115
- C1 -
1IN6
2
RUVB_THEMA
A:
[17-329]
--------------------
Q
F
-
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
R
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
-------------
I
D
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
G
---
L
L
S
S
P
L
R
S
R
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
P
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
96
HHSearch
91.89
52%
-113
- C1 -
1IN4
5
RUVB_THEMA
A:
[17-329]
---------------------
Q
F
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
G
---
L
L
S
S
P
L
R
S
R
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
P
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
4
PsiBlast_PDB
91.50
50%
-111
- C1 -
1IN5
1
RUVB_THEMA
A:
[17-329]
--------------------
Q
F
-
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
I
M
------------
D
I
Q
P
F
T
L
V
G
S
T
T
R
-----------
S
G
---
L
L
S
S
P
L
R
S
R
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
P
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
7
PsiBlast_PDB
91.25
50%
-113
- C1 -
1IN8
1
RUVB_THEMA
A:
[17-329]
--------------------
Q
F
-
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
V
R
-----------
S
G
---
L
L
S
S
P
L
R
S
R
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
P
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
3
PsiBlast_PDB
91.23
50%
-113
- C1 -
1IN4
5
RUVB_THEMA
A:
[17-329]
--------------------
Q
F
-
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
G
---
L
L
S
S
P
L
R
S
R
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
P
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
8
PsiBlast_PDB
90.31
50%
-115
- C1 -
1IN7
3
RUVB_THEMA
A:
[17-329]
--------------------
Q
F
-
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
---------
N
--
I
H
V
------------------------
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
--------------------------
D
----
M
A
A
I
L
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
A
V
------
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
G
---
L
L
S
S
P
L
R
S
A
F
G
I
-
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
--
D
V
E
I
E
D
A
A
---
A
E
M
I
A
K
R
S
-
R
G
T
P
R
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
-----
N
I
---
D
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
-
P
V
G
L
N
A
L
A
A
S
L
----------
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
----------
95
HHSearch
89.50
45%
-112
- C1 -
3PFI
1
RUVB_CAMJE
A:
[23-330]
-----------------------
L
R
P
S
N
F
-
D
G
Y
I
G
Q
E
S
I
K
K
N
L
N
V
F
I
A
A
A
K
K
-------
R
N
E
C
L
D
H
I
L
F
S
G
P
A
G
L
G
K
T
T
L
A
N
I
I
S
Y
E
M
S
A
---------
N
--
I
K
T
------------------------
T
A
A
P
M
I
-----
E
K
---------------------------------
S
----
G
--------------------------
D
----
L
A
A
I
L
T
-
N
------
L
-----
S
E
G
D
I
L
F
I
D
E
I
H
R
L
S
P
A
I
------
E
E
V
L
Y
P
A
M
E
D
Y
R
L
---------
A
Q
T
I
K
I
D
L
P
K
F
T
L
I
G
A
T
T
R
-----------
A
G
---
M
L
S
N
P
L
R
D
R
F
G
M
-
Q
F
R
L
E
F
Y
K
D
S
E
L
A
L
I
L
Q
K
A
A
L
K
L
--
N
K
T
C
E
E
K
A
---
A
L
E
I
A
K
R
S
-
R
S
T
P
R
I
-
A
L
R
L
L
K
R
V
R
D
F
A
D
V
N
D
E
E
I
I
T
E
K
R
A
N
E
A
L
N
S
L
-----
G
V
---
N
E
L
G
F
D
A
M
D
L
R
Y
L
E
L
L
T
A
-
A
K
Q
K
-
P
I
G
L
A
S
I
A
A
A
L
----------
S
E
D
E
N
T
I
E
D
V
I
E
P
Y
L
L
A
N
G
Y
I
E
R
T
A
K
G
R
I
A
S
A
K
S
Y
S
A
L
K
L
N
------------
10
PsiBlast_PDB
89.13
45%
-110
- C1 -
3PFI
1
RUVB_CAMJE
A:
[23-330]
-----------------------
L
R
P
S
N
F
-
D
G
Y
I
G
Q
E
S
I
K
K
N
L
N
V
F
I
A
A
A
K
K
-------
R
N
E
C
L
D
H
I
L
F
S
G
P
A
G
L
G
K
T
T
L
A
N
I
I
S
Y
E
M
S
A
---------
N
--
I
K
T
------------------------
T
A
A
P
M
I
-----
E
K
---------------------------------
S
----
G
--------------------------
D
----
L
A
A
I
L
T
-
N
------
L
-----
S
E
G
D
I
L
F
I
D
E
I
H
R
L
S
P
A
I
------
E
E
V
L
Y
P
A
M
E
D
Y
R
L
---------
A
Q
T
I
K
I
D
L
P
K
F
T
L
I
G
A
T
T
R
-----------
A
G
---
M
L
S
N
P
L
R
D
R
F
G
M
-
Q
F
R
L
E
F
Y
K
D
S
E
L
A
L
I
L
Q
K
A
A
L
K
L
--
N
K
T
C
E
E
K
A
---
A
L
E
I
A
K
R
S
-
R
S
T
P
R
I
-
A
L
R
L
L
K
R
V
R
D
F
A
D
V
N
D
E
E
I
I
T
E
K
R
A
N
E
A
L
N
S
L
-----
G
V
---
N
E
L
G
F
D
A
M
D
L
R
Y
L
E
L
L
T
A
A
-
K
Q
K
-
P
I
G
L
A
S
I
A
A
A
L
----------
S
E
D
E
N
T
I
E
D
V
I
E
P
Y
L
L
A
N
G
Y
I
E
R
T
A
K
G
R
I
A
S
A
K
S
Y
S
A
L
K
L
N
------------
6
PsiBlast_PDB
84.50
56%
-102
- C1 -
1IXR
1
RUVB_THET8
C:
[5-312]
----------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
---------
N
--
L
R
V
------------------------
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
--------------------------
D
----
L
A
A
I
L
A
-
N
S-----
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
Q
A
------
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
G
---
L
I
T
A
P
L
L
S
R
F
G
I
-
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
--
G
V
R
I
T
E
E
A
---
A
L
E
I
G
R
R
S
-
R
G
T
M
R
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-----
G
L
---
D
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
-
P
V
G
L
A
T
L
A
T
A
L
----------
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
A
T
E
L
A
R
R
H
L
---------------
112
HHSearch
58.64
23%
-92
- C1 -
1JR3
2
DPO3X_ECOLI
A:
[4-241]
-----------------
Q
V
L
A
R
K
W
R
P
Q
T
F
-
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
-----------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
---------
E
--
T
G
I
TATPCGVC
D
N
C
R
E
I
E
Q
GRFVDL
I
E
I
D
A
A
S
R
-----
T
K
---------------------------------
V
----
E
--------------------------
D
----
T
R
D
L
L
D
-
N
VQYAPA
R
-----
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
------
F
N
A
L
L
K
T
L
E
E
P
P
------------------
E
H
V
K
F
L
L
A
T
T
D
-----------
P
Q
---
K
L
P
V
T
I
L
S
R
C
-
L
-
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
--
H
I
A
H
E
P
R
A
---
L
Q
L
L
A
R
A
A
-
E
G
S
L
R
D
-
A
L
S
L
T
D
Q
A
I
A
S
G
D
----
G
Q
V
S
T
Q
A
V
S
A
M
L
---------------------------------------------------------------------------------------------------------------
98
HHSearch
57.77
21%
-90
- C1 -
3UK6
1
?
A:
[25-341]
-----------
H
S
H
I
R
G
L
G
L
D
D
A
L
E
P
R
Q
A
S
Q
G
M
V
G
Q
L
A
A
R
R
A
A
G
V
V
L
E
M
I
R
E
-------
G
K
I
A
G
R
A
V
L
I
A
G
Q
P
G
T
G
K
T
A
I
A
M
G
M
A
Q
A
L
G
P
---------
D
T
P
F
T
A
------------------------
I
A
G
S
E
I
FSLEM
S
K
T
E
A
L
T
Q
A
F
R
R
S
I
G
V
R
ITVS
L
H
E
I
D
V
I
N
SFLALF
K
S
E
V
R
E
--------------------------
Q
----
I
N
A
K
V
A
-
E
------
W
R
E
E
GK-
I
P
G
V
L
F
I
D
E
V
H
M
L
D
I
E
S
------
F
S
F
L
N
R
A
L
E
S
D
M
------------------
A
P
V
L
I
M
A
T
N
R
G
ITRIRGTSYQS
P
H
---
G
I
P
I
D
L
L
D
R
L
L
--
I
V
S
T
T
P
Y
S
E
K
D
T
K
Q
I
L
R
I
R
C
E
E
E
--
D
V
E
M
S
E
D
A
---
Y
T
V
L
T
R
I
G
L
E
T
S
L
R
Y
-
A
I
Q
L
I
T
A
A
S
L
V
C
R
K
R
K
G
T
E
V
Q
V
D
D
I
K
R
V
Y
S
L
F
-----
L
D
E
S
R
S
T
Q
Y
M
K
--------------------------------------------------------------------------------------------
109
HHSearch
55.90
19%
-92
- C1 -
3D8B
2
FIGL1_HUMAN
A:
[77-314]
----------------------
H
G
P
P
V
N
W
-
E
D
I
A
G
V
E
F
A
K
A
T
I
K
E
I
V
V
W
P
M
L
R
P
DIFTG
L
R
G
P
P
K
G
I
L
L
F
G
P
P
G
T
G
K
T
L
I
G
K
C
I
A
S
Q
S
G
A
---------
T
--
F
F
S
------------------------
I
S
A
S
S
L
-----
T
S
KWVG
E
G
---------------------------
E
----
K
--------------------------
M
----
V
R
A
L
F
A
-
V
A
R
----
C
-----
Q
Q
P
A
V
I
F
I
D
E
I
D
S
L
L
S
Q
-E
S
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
------------------
S
E
D
R
I
L
V
V
G
A
T
N
R
-----------
P
Q
---
E
I
D
E
A
A
R
R
R
L
V
K
-
R
L
Y
I
P
L
P
E
A
S
A
R
K
Q
I
V
I
N
L
M
S
K
E
--
Q
C
C
L
S
E
E
E
---
I
E
Q
I
V
Q
Q
S
-
D
A
F
S
G
A
D
M
T
Q
L
C
R
E
A
S
L
G
P
I
R
------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
55.88
21%
-95
- C1 -
1IQP
1
RFCS_PYRFU
A:
[13-230]
-----------------
K
P
W
V
E
K
Y
R
P
Q
R
L
-
D
D
I
V
G
Q
E
H
I
V
K
R
L
K
H
Y
V
K
T
------------
G
S
M
P
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
L
F
G
ENWRH----
N
--
F
L
E
------------------------
L
N
A
S
D
E
-----
R
G
---------------------------------
I
----
N
--------------------------
V
I
R
E
K
V
K
E
F
A
R
-
T
KPIG--
G
-----
A
S
F
K
I
I
F
L
D
E
A
D
A
L
T
Q
D
A
------
Q
Q
A
L
R
R
T
M
E
M
F
S
------------------
S
N
V
R
F
I
L
S
C
N
Y
-----------
S
S
---
K
I
I
E
P
I
Q
S
R
C
A
--
I
F
R
F
R
P
L
R
D
E
D
I
A
K
R
L
R
Y
I
A
E
N
E
--
G
L
E
L
T
E
E
G
---
L
Q
A
I
L
Y
I
A
-
E
G
D
M
R
R
-
A
I
N
I
L
Q
A
A
A
A
L
D
K
-----
K
I
T
D
E
N
V
F
M
V
----------------------------------------------------------------------------------------------------------------
108
HHSearch
55.80
22%
-100
- C1 -
2V1U
4
CDC61_AERPE
A:
[18-353]
----------------------------
P
-
D
V
L
P
H
R
E
A
E
L
R
R
L
A
E
V
L
A
P
A
L
R
--------
G
E
K
P
S
N
A
L
L
Y
G
L
T
G
T
G
K
T
A
V
A
R
L
V
L
R
R
L
E
A
R
A
S
S
L
GV
L
V
K
--
P
I
Y
------------------------
V
N
A
R
H
R
-----
E
T
---------------------------------
P
----
Y
R
V
A
S
A
I
A
E
A
V
G
V
R
V
PFTGLS
V
G
E
V
Y
E
R
----
L
V
K
R
L
S
-
R
------
L
-----
R
G
I
Y
I
I
V
L
D
E
I
D
F
L
P
K
R
P
G
G
----
Q
D
L
L
Y
R
I
T
R
I
N
Q
E
L
------------------
V
S
L
V
G
I
T
N
S
-----------
L
G
FVE
N
L
E
P
R
V
K
S
S
L
G
E
V
E
L
V
F
P
P
Y
T
A
P
Q
L
R
D
I
L
E
T
R
A
E
E
A
FN
P
G
V
L
D
P
D
V
V
P
L
C
A
A
L
A
A
R
E
-
H
G
D
A
R
R
-
A
L
D
L
L
R
V
A
G
E
I
A
E
R
R
R
E
E
R
V
R
R
E
H
V
Y
S
A
R
A
E
I
E
R
D
R
V
S
E
---
V
V
R
T
L
P
L
H
A
K
L
V
L
L
S
I
M
M
L
E
D
G
G
R
P
A
S
T
G
E
I
Y
E
R
Y
K
E
L
T
S
T
L
G
L
E
H
V
T
L
R
R
V
S
G
I
I
S
E
-
L
D
M
L
G
I
V
K
S
R
V
V
---------------------------