@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2606c: (2016-05-12 )
MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQTLGVDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEGAAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAPYELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQRGW
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110....--...120.......130.......140.......150.......160.......170.......180-.....-------------------------------------..----190.....-------------------------------------..200.......210...--....220.......230.......240.......250.......260.......270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDPAGNPAT
G
T
A
R
V
K
R
G
M
A
E
M
LKG
G
V
I
M
D
VVTP
E
Q
A
R
I
AEGA
G
A
V
A
V
M
A
L
E
RV
P
A
D
I
RAQGGVSRMS
D
P
D
M
I
E
G
I
I
A
A
V
T
I
P
V
M
A
K
V
RIG
H
F
V
E
A
Q
I
L
Q
T
LGVDYIDESEVLT
P
A
D
--
Y
A
H
HIDKWN
F
T
V
P
F
VCGA
T
N
L
G
E
A
L
R
R
I
S
E
G
A
A
M
I
RSKGEAGTGDVSN
A
T
T
H
M
R
A
I
G
G
E
I
R
R
L
TSM-SE
D
E
L
-------------------------------------
F
V
----
A
A
K
E
LQ
A
P
-------------------------------------
Y
E
L
V
A
E
V
A
RAGKL
P
V
T
L
F
--TAGGIAT
P
A
D
A
A
M
M
M
Q
LGAE
G
V
F
VGSGIFKSGAPE
H
R
A
A
A
I
V
K
A
T
TFFD
D
P
D
V
L
A
K
V
S
R
GL
G
E
A
MVGI
N
V
D
E
I
A
V
G
H
R
L
A
QRGW
21
PsiBlast_CBE
97.79
100%
-120
- C5 -
4JDY
1
PDXS_MYCTU
C:
[1-264]
----------
T
A
R
V
K
R
G
M
A
E
M
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
R
I
A
E
G
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
S
R
M
S
D
P
D
M
I
E
G
I
I
A
A
V
T
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
L
Q
T
L
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
Y
A
H
H
I
D
K
W
N
F
T
V
P
F
V
C
G
A
T
N
L
G
E
A
L
R
R
I
S
E
G
A
A
M
I
R
S
K
G
E
A
G
T
G
D
V
S
N
A
T
T
H
M
R
A
I
G
G
E
I
R
R
L
T
S
M
-
S
E
D
E
L
-------------------------------------
F
V
----
A
A
K
E
L
Q
A
P
-------------------------------------
Y
E
L
V
A
E
V
A
R
A
G
K
L
P
V
T
L
F
--
T
A
G
G
I
A
T
P
A
D
A
A
M
M
M
Q
L
G
A
E
G
V
F
V
G
S
G
I
F
K
S
G
A
P
E
H
R
A
A
A
I
V
K
A
T
T
F
F
D
D
P
D
V
L
A
K
V
S
R
-------------------------
1
PsiBlast_PDB
97.35
100%
-120
- C5 -
4JDY
1
PDXS_MYCTU
A:
[1-264]
----------
T
A
R
V
K
R
G
M
A
E
M
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
R
I
A
E
G
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
S
R
M
S
D
P
D
M
I
E
G
I
I
A
A
V
T
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
L
Q
T
L
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
Y
A
H
H
I
D
K
W
N
F
T
V
P
F
V
C
G
A
T
N
L
G
E
A
L
R
R
I
S
E
G
A
A
M
I
R
S
K
G
E
A
G
T
G
D
V
S
N
A
T
T
H
M
R
A
I
G
G
E
I
R
R
L
T
S
M
-
S
E
D
E
L
-------------------------------------
F
V
----
A
A
K
E
L
Q
A
P
-------------------------------------
Y
E
L
V
A
E
V
A
R
A
G
K
L
P
V
T
L
F
--
T
A
G
G
I
A
T
P
A
D
A
A
M
M
M
Q
L
G
A
E
G
V
F
V
G
S
G
I
F
K
S
G
A
P
E
H
R
A
A
A
I
V
K
A
T
T
F
F
D
D
P
D
V
L
A
K
V
S
R
-------------------------
22
PsiBlast_CBE
96.32
100%
-119
- C5 -
4JDY
1
PDXS_MYCTU
B:
[1-264]
----------
T
A
R
V
K
R
G
M
A
E
M
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
R
I
A
E
G
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
S
R
M
S
D
P
D
M
I
E
G
I
I
A
A
V
T
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
L
Q
T
L
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
Y
A
H
H
I
D
K
W
N
F
T
V
P
F
V
C
G
A
T
N
L
G
E
A
L
R
R
I
S
E
G
A
A
M
I
R
S
K
G
E
A
G
T
G
D
V
S
N
A
T
T
H
M
R
A
I
G
G
E
I
R
R
L
T
S
M
-
S
E
D
E
L
-------------------------------------
F
V
----
A
A
K
E
L
Q
A
P
-------------------------------------
Y
E
L
V
A
E
V
A
R
A
G
K
L
P
V
T
L
F
--
T
A
G
G
I
A
T
P
A
D
A
A
M
M
M
Q
L
G
A
E
G
V
F
V
G
S
G
I
F
K
S
G
A
P
E
H
R
A
A
A
I
V
K
A
T
T
F
F
D
D
P
D
V
L
A
K
V
S
R
-------------------------
2
PsiBlast_PDB
91.97
69%
-118
- C5 -
2ZBT
1
PDXS_THET8
A:
[3-278]
----
G
G
M
E
K
G
T
F
Q
I
K
T
G
F
A
E
M
F
K
G
G
V
I
M
D
V
T
T
P
E
Q
A
V
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
A
R
M
S
D
P
K
I
I
K
E
I
M
A
A
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
M
I
L
E
A
I
G
V
D
F
I
D
E
S
E
V
L
T
P
A
D
--
E
E
H
H
I
D
K
W
K
F
K
V
P
F
V
C
G
A
R
N
L
G
E
A
L
R
R
I
A
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
V
V
E
A
V
R
H
A
R
T
M
W
K
E
I
R
Y
V
Q
S
L
-
R
E
D
E
L
-------------------------------------
M
A
----
Y
A
K
E
I
G
A
P
-------------------------------------
F
E
L
V
K
W
V
H
D
H
G
R
L
P
V
V
N
F
--
A
A
G
G
I
A
T
P
A
D
A
A
L
M
M
H
L
G
M
D
G
V
F
V
G
S
G
I
F
K
S
G
D
P
R
K
R
A
R
A
I
V
R
A
V
A
H
Y
N
D
P
E
V
L
A
E
V
S
E
D
L
G
E
P
M
-------------------
25
PsiBlast_CBE
91.06
69%
-119
- C5 -
2ZBT
1
PDXS_THET8
B:
[5-278]
------
M
E
K
G
T
F
Q
I
K
T
G
F
A
E
M
F
K
G
G
V
I
M
D
V
T
T
P
E
Q
A
V
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
A
R
M
S
D
P
K
I
I
K
E
I
M
A
A
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
M
I
L
E
A
I
G
V
D
F
I
D
E
S
E
V
L
T
P
A
D
--
E
E
H
H
I
D
K
W
K
F
K
V
P
F
V
C
G
A
R
N
L
G
E
A
L
R
R
I
A
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
V
V
E
A
V
R
H
A
R
T
M
W
K
E
I
R
Y
V
Q
S
L
-
R
E
D
E
L
-------------------------------------
M
A
----
Y
A
K
E
I
G
A
P
-------------------------------------
F
E
L
V
K
W
V
H
D
H
G
R
L
P
V
V
N
F
--
A
A
G
G
I
A
T
P
A
D
A
A
L
M
M
H
L
G
M
D
G
V
F
V
G
S
G
I
F
K
S
G
D
P
R
K
R
A
R
A
I
V
R
A
V
A
H
Y
N
D
P
E
V
L
A
E
V
S
E
D
L
G
E
P
M
-------------------
23
PsiBlast_CBE
90.73
69%
-117
- C5 -
2ZBT
1
PDXS_THET8
D:
[5-278]
------
M
E
K
G
T
F
Q
I
K
T
G
F
A
E
M
F
K
G
G
V
I
M
D
V
T
T
P
E
Q
A
V
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
A
R
M
S
D
P
K
I
I
K
E
I
M
A
A
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
M
I
L
E
A
I
G
V
D
F
I
D
E
S
E
V
L
T
P
A
D
--
E
E
H
H
I
D
K
W
K
F
K
V
P
F
V
C
G
A
R
N
L
G
E
A
L
R
R
I
A
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
V
V
E
A
V
R
H
A
R
T
M
W
K
E
I
R
Y
V
Q
S
L
-
R
E
D
E
L
-------------------------------------
M
A
----
Y
A
K
E
I
G
A
P
-------------------------------------
F
E
L
V
K
W
V
H
D
H
G
R
L
P
V
V
N
F
--
A
A
G
G
I
A
T
P
A
D
A
A
L
M
M
H
L
G
M
D
G
V
F
V
G
S
G
I
F
K
S
G
D
P
R
K
R
A
R
A
I
V
R
A
V
A
H
Y
N
D
P
E
V
L
A
E
V
S
E
D
L
G
E
P
M
-------------------
24
PsiBlast_CBE
89.95
69%
-119
- C5 -
2ZBT
1
PDXS_THET8
C:
[9-278]
----------
T
F
Q
I
K
T
G
F
A
E
M
F
K
G
G
V
I
M
D
V
T
T
P
E
Q
A
V
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
A
R
M
S
D
P
K
I
I
K
E
I
M
A
A
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
M
I
L
E
A
I
G
V
D
F
I
D
E
S
E
V
L
T
P
A
D
--
E
E
H
H
I
D
K
W
K
F
K
V
P
F
V
C
G
A
R
N
L
G
E
A
L
R
R
I
A
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
V
V
E
A
V
R
H
A
R
T
M
W
K
E
I
R
Y
V
Q
S
L
-
R
E
D
E
L
-------------------------------------
M
A
----
Y
A
K
E
I
G
A
P
-------------------------------------
F
E
L
V
K
W
V
H
D
H
G
R
L
P
V
V
N
F
--
A
A
G
G
I
A
T
P
A
D
A
A
L
M
M
H
L
G
M
D
G
V
F
V
G
S
G
I
F
K
S
G
D
P
R
K
R
A
R
A
I
V
R
A
V
A
H
Y
N
D
P
E
V
L
A
E
V
S
E
D
L
G
E
P
M
-------------------
45
PsiBlast_CBE
87.94
63%
-122
- C5 -
2NV1
2
PDXS_BACSU
C:
[10-274]
-----------
E
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
I
N
A
E
Q
A
K
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
---------
G
V
A
R
M
A
D
P
T
I
V
E
E
V
M
N
A
V
S
I
P
V
M
A
K
A
R
I
G
H
I
V
E
A
R
V
L
E
A
M
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
L
N
K
N
E
Y
T
V
P
F
V
C
G
C
R
D
L
G
E
A
T
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
V
R
K
V
V
A
M
-
S
E
D
E
L
-------------------------------------
M
T
----
E
A
K
N
L
G
A
P
-------------------------------------
Y
E
L
L
L
Q
I
K
K
D
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
Q
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
D
N
P
A
K
F
A
K
A
I
V
E
A
T
T
H
F
T
D
Y
K
L
I
A
E
L
S
K
E
L
-----------------------
47
PsiBlast_CBE
87.86
63%
-113
- C5 -
2NV2
32
PDXS_BACSU
W:
[4-271]
--------
T
G
T
E
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
I
N
A
E
Q
A
K
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
A
G
G
V
A
R
M
A
D
P
T
I
V
E
E
V
M
N
A
V
S
I
P
V
M
A
K
A
R
I
G
H
I
V
E
A
R
V
L
E
A
M
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
L
N
K
N
E
Y
T
V
P
F
V
C
G
C
R
D
L
G
E
A
T
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
V
R
K
V
V
A
M
-
S
E
D
E
L
-------------------------------------
M
T
----
E
A
K
N
L
G
A
P
-------------------------------------
Y
E
L
L
L
Q
I
K
K
D
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
Q
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
D
N
P
A
K
F
A
K
A
I
V
E
A
T
T
H
F
T
D
Y
K
L
I
A
E
L
S
K
E
L
-----------------------
5
PsiBlast_PDB
87.85
65%
-106
- C5 -
4WXY
-
PDXS_GEOKA
A:
[4-290]
--------
T
G
T
D
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
V
N
A
E
Q
A
K
I
A
E
A
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
A
G
G
V
A
R
M
A
D
P
T
V
I
E
E
V
M
N
A
V
S
I
P
V
M
A
-
V
R
I
G
H
Y
V
E
A
R
V
L
E
A
L
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
I
D
K
R
Q
F
T
V
P
F
V
C
G
C
R
D
L
G
E
A
A
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
I
R
K
V
V
N
M
-
S
E
D
E
L
-------------------------------------
V
A
----
E
A
K
Q
L
G
A
P
-------------------------------------
V
E
V
L
R
E
I
K
R
L
G
R
L
P
V
V
N
F
--
A
A
G
G
V
T
T
P
A
D
A
A
L
M
M
H
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
E
N
P
E
K
Y
A
R
A
I
V
E
A
T
T
H
Y
E
D
Y
E
L
I
A
H
L
S
K
G
L
G
G
A
M
R
G
I
D
I
A
T
L
L
P
E
H
R
M
Q
----
18
PsiBlast_PDB
87.51
53%
-120
- C5 -
4FIQ
-
PDXS_PYRHO
A:
[11-316]
---------
G
T
E
R
L
K
R
G
F
A
K
M
V
K
G
G
V
I
M
D
V
T
N
A
E
Q
A
R
I
A
E
E
A
G
A
V
A
V
M
A
L
H
K
V
P
A
D
I
R
K
A
G
G
V
A
R
M
A
P
V
E
K
I
Q
E
I
M
D
A
V
T
I
P
V
M
A
K
C
R
I
G
H
E
A
E
A
R
I
L
E
A
L
G
V
D
M
I
D
E
S
E
V
L
T
P
A
D
--
P
F
F
H
I
Y
K
K
K
F
T
A
P
F
V
C
G
A
R
N
L
G
E
A
V
R
R
I
W
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
I
I
E
A
V
R
H
V
R
L
V
N
E
N
I
R
L
I
Q
R
M
-
T
D
E
E
I
-------------------------------------
Y
G
----
V
A
E
K
F
A
E
P
YL
R
L
A
F
S
V
K
E
I
S
GLPKRVLENEPIYEGFT
Y
R
E
I
V
E
D
I
Y
K
I
L
L
E
I
K
K
L
G
R
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
A
M
G
M
D
G
V
F
V
G
S
G
I
F
K
S
S
N
P
P
K
M
A
R
A
I
V
E
A
V
N
H
W
D
E
P
D
V
L
A
E
I
S
R
E
I
G
E
---------------------
104
HHSearch
87.35
63%
-120
- C5 -
2NV1
2
PDXS_BACSU
A:
[9-274]
----------
T
E
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
I
N
A
E
Q
A
K
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
-------
A
G
G
V
A
R
M
A
D
P
T
I
V
E
E
V
M
N
A
V
S
I
P
V
M
A
K
A
R
I
G
H
I
V
E
A
R
V
L
E
A
M
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
L
N
K
N
E
Y
T
V
P
F
V
C
G
C
R
D
L
G
E
A
T
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
V
R
K
V
V
A
M
-
S
E
D
E
L
-------------------------------------
M
T
----
E
A
K
N
L
G
A
P
-------------------------------------
Y
E
L
L
L
Q
I
K
K
D
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
Q
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
D
N
P
A
K
F
A
K
A
I
V
E
A
T
T
H
F
T
D
Y
K
L
I
A
E
L
S
K
E
L
-----------------------
7
PsiBlast_PDB
87.35
63%
-120
- C5 -
2NV1
2
PDXS_BACSU
A:
[9-274]
----------
T
E
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
I
N
A
E
Q
A
K
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
-------
A
G
G
V
A
R
M
A
D
P
T
I
V
E
E
V
M
N
A
V
S
I
P
V
M
A
K
A
R
I
G
H
I
V
E
A
R
V
L
E
A
M
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
L
N
K
N
E
Y
T
V
P
F
V
C
G
C
R
D
L
G
E
A
T
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
V
R
K
V
V
A
M
-
S
E
D
E
L
-------------------------------------
M
T
----
E
A
K
N
L
G
A
P
-------------------------------------
Y
E
L
L
L
Q
I
K
K
D
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
Q
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
D
N
P
A
K
F
A
K
A
I
V
E
A
T
T
H
F
T
D
Y
K
L
I
A
E
L
S
K
E
L
-----------------------
10
PsiBlast_PDB
87.27
63%
-120
- C5 -
3O05
1
SNZ1_YEAST
A:
[9-269]
--------------------
M
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
K
I
A
E
K
S
G
A
C
A
V
M
A
L
E
S
I
P
A
D
M
R
K
S
G
K
V
C
R
M
S
D
P
K
M
I
K
D
I
M
N
S
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
I
E
A
L
E
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
W
T
H
H
I
E
K
D
K
F
K
V
P
F
V
C
G
A
K
D
L
G
E
A
L
R
R
I
N
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
D
V
S
E
A
V
K
H
I
R
R
I
T
E
E
I
K
A
C
Q
Q
L
K
S
E
D
D
I
-------------------------------------
A
K
----
V
A
E
E
M
R
V
P
-------------------------------------
V
S
L
L
K
D
V
L
E
K
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
L
M
Q
L
G
C
D
G
V
F
V
G
S
G
I
F
K
S
S
N
P
V
R
L
A
T
A
V
V
E
A
T
T
H
F
D
N
P
S
K
L
L
E
V
S
S
D
L
G
E
L
M
-------------------
3
PsiBlast_PDB
87.25
65%
-117
- C5 -
4WY0
2
PDXS_GEOKA
B:
[16-282]
----------
T
D
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
V
N
A
E
Q
A
K
I
A
E
A
A
G
A
V
A
V
M
A
L
E
R
-------
A
G
G
V
A
R
M
A
D
P
T
V
I
E
E
V
M
N
A
V
S
I
P
V
M
A
K
V
R
I
G
H
Y
V
E
A
R
V
L
E
A
L
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
I
D
K
R
Q
F
T
V
P
F
V
C
G
C
R
D
L
G
E
A
A
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
I
R
K
V
V
N
M
-
S
E
D
E
L
-------------------------------------
V
A
----
E
A
K
Q
L
G
A
P
-------------------------------------
V
E
V
L
R
E
I
K
R
L
G
R
L
P
V
V
N
F
--
A
A
G
G
V
T
T
P
A
D
A
A
L
M
M
H
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
E
N
P
E
K
Y
A
R
A
I
V
E
A
T
T
H
Y
E
D
Y
E
L
I
A
H
L
S
K
G
L
G
----------------------
61
PsiBlast_CBE
87.18
63%
-121
- C5 -
3O05
1
SNZ1_YEAST
B:
[9-269]
--------------------
M
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
K
I
A
E
K
S
G
A
C
A
V
M
A
L
E
S
I
P
A
D
M
R
K
S
G
K
V
C
R
M
S
D
P
K
M
I
K
D
I
M
N
S
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
I
E
A
L
E
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
W
T
H
H
I
E
K
D
K
F
K
V
P
F
V
C
G
A
K
D
L
G
E
A
L
R
R
I
N
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
D
V
S
E
A
V
K
H
I
R
R
I
T
E
E
I
K
A
C
Q
Q
L
K
S
E
D
D
I
-------------------------------------
A
K
----
V
A
E
E
M
R
V
P
-------------------------------------
V
S
L
L
K
D
V
L
E
K
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
L
M
Q
L
G
C
D
G
V
F
V
G
S
G
I
F
K
S
S
N
P
V
R
L
A
T
A
V
V
E
A
T
T
H
F
D
N
P
S
K
L
L
E
V
S
S
D
L
G
E
L
M
-------------------
58
PsiBlast_CBE
87.16
63%
-124
- C5 -
3O07
2
SNZ1_YEAST
C:
[10-268]
---------------------
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
K
I
A
E
K
S
G
A
C
A
V
M
A
L
E
S
I
P
A
D
M
R
K
S
G
K
V
C
R
M
S
D
P
K
M
I
K
D
I
M
N
S
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
I
E
A
L
E
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
W
T
H
H
I
E
K
D
K
F
K
V
P
F
V
C
G
A
K
D
L
G
E
A
L
R
R
I
N
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
D
V
S
E
A
V
K
H
I
R
R
I
T
E
E
I
K
A
C
Q
Q
L
K
S
E
D
D
I
-------------------------------------
A
K
----
V
A
E
E
M
R
V
P
-------------------------------------
V
S
L
L
K
D
V
L
E
K
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
L
M
Q
L
G
C
D
G
V
F
V
G
S
G
I
F
K
S
S
N
P
V
R
L
A
T
A
V
V
E
A
T
T
H
F
D
N
P
S
K
L
L
E
V
S
S
D
L
G
E
L
--------------------
44
PsiBlast_CBE
87.08
63%
-120
- C5 -
2NV1
2
PDXS_BACSU
D:
[11-275]
------------
R
V
K
R
G
M
A
E
M
Q
K
G
G
V
I
M
D
V
I
N
A
E
Q
A
K
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
---------
G
V
A
R
M
A
D
P
T
I
V
E
E
V
M
N
A
V
S
I
P
V
M
A
K
A
R
I
G
H
I
V
E
A
R
V
L
E
A
M
G
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
E
E
F
H
L
N
K
N
E
Y
T
V
P
F
V
C
G
C
R
D
L
G
E
A
T
R
R
I
A
E
G
A
S
M
L
R
T
K
G
E
P
G
T
G
N
I
V
E
A
V
R
H
M
R
K
V
N
A
Q
V
R
K
V
V
A
M
-
S
E
D
E
L
-------------------------------------
M
T
----
E
A
K
N
L
G
A
P
-------------------------------------
Y
E
L
L
L
Q
I
K
K
D
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
Q
L
G
A
D
G
V
F
V
G
S
G
I
F
K
S
D
N
P
A
K
F
A
K
A
I
V
E
A
T
T
H
F
T
D
Y
K
L
I
A
E
L
S
K
E
L
G
----------------------
14
PsiBlast_PDB
86.87
54%
-111
- C5 -
2YZR
4
PDXS_METJA
A:
[5-313]
----------
T
D
L
L
K
K
G
F
A
K
M
V
K
H
G
V
V
M
D
V
T
N
V
E
Q
A
Q
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
--
G
G
V
A
R
M
S
D
P
A
L
I
E
E
I
M
D
A
V
S
I
P
V
M
A
K
C
R
I
G
H
T
T
E
A
L
V
L
E
A
I
G
V
D
M
I
D
E
S
E
V
L
T
Q
A
D
--
P
F
F
H
I
Y
K
K
K
F
N
V
P
F
V
C
G
A
R
N
L
G
E
A
V
R
R
I
W
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
I
V
E
A
V
R
H
M
R
L
M
N
E
A
I
A
Q
L
Q
R
M
-
T
D
E
E
V
Y
G
V
A
K
F
Y
A
NRYA
E
L
A
K
T
V
R
E
G
M
GLPATVLENEPIYEG
F
T
----
L
A
E
I
I
D
G
L
-------------------------------------
Y
E
V
L
L
E
V
K
K
L
G
R
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
M
M
Q
L
G
S
D
G
V
F
V
G
S
G
I
F
K
S
E
N
P
L
E
R
A
R
A
I
V
E
A
T
Y
N
Y
D
K
P
D
I
V
A
E
V
S
K
N
L
G
E
A
M
K
G
-----------------
12
PsiBlast_PDB
86.84
63%
-123
- C5 -
3O07
1
SNZ1_YEAST
A:
[10-268]
---------------------
L
K
G
G
V
I
M
D
V
V
T
P
E
Q
A
K
I
A
E
K
S
G
A
C
A
V
M
A
L
E
S
I
P
A
D
M
R
K
S
G
K
V
C
R
M
S
D
P
K
M
I
K
D
I
M
N
S
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
Q
I
I
E
A
L
E
V
D
Y
I
D
E
S
E
V
L
T
P
A
D
--
W
T
H
H
I
E
K
D
K
F
K
V
P
F
V
C
G
A
K
D
L
G
E
A
L
R
R
I
N
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
D
V
S
E
A
V
K
H
I
R
R
I
T
E
E
I
K
A
C
Q
Q
L
K
S
E
D
D
I
-------------------------------------
A
K
----
V
A
E
E
M
R
V
P
-------------------------------------
V
S
L
L
K
D
V
L
E
K
G
K
L
P
V
V
N
F
--
A
A
G
G
V
A
T
P
A
D
A
A
L
L
M
Q
L
G
C
D
G
V
F
V
G
S
G
I
F
K
S
S
N
P
V
R
L
A
T
A
V
V
E
A
T
T
H
F
D
N
P
S
K
L
L
E
V
S
S
D
L
G
E
L
--------------------
105
HHSearch
84.98
67%
-107
- C5 -
2ZBT
1
PDXS_THET8
A:
[5-278]
------
M
E
K
G
T
F
Q
I
K
T
G
F
A
E
M
F
K
G
G
V
I
M
D
V
T
T
P
E
Q
A
V
I
A
E
E
A
G
A
V
A
V
M
A
L
E
R
V
P
A
D
I
R
A
Q
G
G
V
A
R
M
S
D
P
K
I
I
K
E
I
M
A
A
V
S
I
P
V
M
A
K
V
R
I
G
H
F
V
E
A
M
I
L
E
A
I
G
V
D
F
I
D
E
S
E
V
L
T
P
A
D
EE
H
H
I
D
K
W
K
-
F
-
K
V
P
F
V
C
G
A
R
N
L
G
E
A
L
R
R
I
A
E
G
A
A
M
I
R
T
K
G
E
A
G
T
G
N
V
V
E
A
V
R
H
A
R
T
M
W
K
E
I
---
R
-
Y
-
V
Q
S
L
R
-------------------------------------
E
D
E
L
M
A
Y
A
K
E
I
G
A
P
-------------------------------------
F
E
L
V
K
W
V
H
D
H
G
R
L
P
V
--
V
N
F
A
A
G
G
I
A
T
P
A
D
A
A
L
M
M
H
L
G
M
D
G
V
F
V
G
S
G
I
F
K
S
G
D
P
R
K
R
A
R
A
I
V
R
A
V
A
H
Y
N
D
P
E
V
L
A
E
V
S
E
D
L
G
E
P
M
-------------------
66
PsiBlast_CBE
84.85
58%
-114
- C5 -
4ADU
3
PDX1_PLABE
B:
[12-280]
-------------
L
K
H
G
W
C
E
M
L
K
G
G
V
I
M
D
V
K
N
V
E
Q
A
K
I
A
E
K
A
G
A
I
G
V
M
I
L
E
N
I
P
S
E
L
R
N
T
D
G
V
A
R
S
V
D
P
L
K
I
E
E
I
R
K
C
I
S
I
N
V
L
A
K
V
R
I
G
H
F
V
E
A
Q
I
L
E
E
L
K
V
D
M
L
D
E
S
E
V
L
T
M
A
D
--
E
Y
N
H
I
N
K
H
K
F
K
T
P
F
V
C
G
C
T
N
L
G
E
A
L
R
R
I
S
E
G
A
S
M
I
R
T
K
G
E
A
G
T
G
N
I
I
E
A
I
K
H
I
R
T
V
N
N
E
I
K
Y
L
C
S
L
-
D
E
S
E
V
-------------------------------------
Y
N
----
F
A
K
K
L
R
A
P
-------------------------------------
I
D
L
I
L
L
T
R
K
L
K
R
L
P
V
V
N
F
--
A
A
G
G
I
A
T
P
A
D
A
A
M
C
M
Q
L
G
M
D
G
V
F
V
G
S
G
I
F
E
S
E
N
P
Q
K
M
A
S
S
I
V
M
A
V
S
N
F
N
N
P
K
I
L
L
N
V
S
L
G
L
G
K
A
M
H
G
-----------------
16
PsiBlast_PDB
84.65
58%
-116
- C5 -
4ADU
2
PDX1_PLABE
A:
[12-280]
-------------
L
K
H
G
W
C
E
M
L
K
G
G
V
I
M
D
V
K
N
V
E
Q
A
K
I
A
E
K
A
G
A
I
G
V
M
I
L
E
N
I
P
S
E
L
R
N
T
D
G
V
A
R
S
V
D
P
L
K
I
E
E
I
R
K
C
I
S
I
N
V
L
A
K
V
R
I
G
H
F
V
E
A
Q
I
L
E
E
L
K
V
D
M
L
D
E
S
E
V
L
T
M
A
D
--
E
Y
N
H
I
N
K
H
K
F
K
T
P
F
V
C
G
C
T
N
L
G
E
A
L
R
R
I
S
E
G
A
S
M
I
R
T
K
G
E
A
G
T
G
N
I
I
E
A
I
K
H
I
R
T
V
N
N
E
I
K
Y
L
C
S
L
-
D
E
S
E
V
-------------------------------------
Y
N
----
F
A
K
K
L
R
A
P
-------------------------------------
I
D
L
I
L
L
T
R
K
L
K
R
L
P
V
V
N
F
--
A
A
G
G
I
A
T
P
A
D
A
A
M
C
M
Q
L
G
M
D
G
V
F
V
G
S
G
I
F
E
S
E
N
P
Q
K
M
A
S
S
I
V
M
A
V
S
N
F
N
N
P
K
I
L
L
N
V
S
L
G
L
G
K
A
M
H
G
-----------------