@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2678c: (2016-05-12 )
MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACEITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAADVAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGPSRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVPMTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVERAARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
Atome Classification :
(24 SA)
.........10........20........30........40-.-....--.-.-..50........60........-70.........80........90........100.......110......--.-120.-...----.....130....-.------.------.140.......150.......160..--.---.---...-170.......180.......190.......200.......210.......220....----...230..-.-..-------.----.---240.......250.......260.......-270.......280.......290.......300.......310.......320...---....330.......340.......350.....------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTRRDLPQSP
Y
L
A
A
VTGRKPSRVP
V
W
F
M
R
Q
AGRS
L
P
E
Y
R
--
A
-
L
R
E
R
--
Y
-
S
-
M
L
A
A
C
FEPD
V
A
C
E
I
T
L
Q
P
I
R
RY-D-V
D
A
A
I
L
F
S
D
I
V
V
P
L
RAAGV
D
L
D
I
V
ADV
G
P
V
I
A
D
P
V
R
T
A
A
D
V
AAMKPL
D
--
P
-
Q
--
A
-
I
Q
P
----
V
L
V
A
A
S
L
L
V
A
EL-G------D------V
P
L
IGFAGA
P
F
T
L
A
S
Y
L
VEGGPSR
H
H
--
A
---
H
---
V
K
A
-
M
M
LAEP
A
S
W
H
A
L
M
A
K
L
T
D
L
T
I
A
F
L
V
G
QIDAG
V
D
A
I
Q
V
F
D
S
WAGALSP
I
D
Y
R
Q
YVLPH----
S
A
R
V
F
A
A
L-G-EH-------G----V---P
M
T
HFGV
G
T
A
E
L
L
G
A
M
S
E
A
V
TAGERPGRG
A
-
V
V
G
VDWRTP
L
T
D
A
A
A
RVVPGTALQGNLD
P
A
V
V
LAG
W
P
A
V
E
R
A
A
R
A
V
V
DDGRRAVDA---GAAGH
I
F
NLGHGVLPES
D
P
A
V
L
A
D
L
V
S
L
V
HSL------
2
PsiBlast_PDB
95.21
41%
-118
- C2 -
4ZR8
6
?
A:
[12-358]
------
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
--
E
-
T
R
S
K
--
A
G---
L
S
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
P
K
L
N
--
A
-
K
--
A
D
L
D
Y
----
V
M
N
A
V
S
T
I
R
S
A
L
-
G
G-----
Q
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
E
F
--
R
---
F
---
T
K
Q
-
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
F
S
L
N
Y
----
M
K
K
I
I
A
G
L
-
Q
-
R
E
-------
K
DG
R
R
I
---
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
---
I
T
T
G
-----
A
D
-
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
--
A
N
G
---
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
-------
37
HHSearch
95.19
45%
-120
- C2 -
2INF
-
DCUP_BACSU
A:
[6-343]
------
T
F
N
E
T
F
L
K
A
A
R
G
E
K
A
D
H
T
P
V
W
Y
M
R
Q
A
G
R
S
Q
P
E
Y
R
--
K
-
L
K
E
K
--
Y
-
G
-
L
F
E
I
T
H
Q
P
E
L
C
A
Y
V
T
R
L
P
V
E
Q
Y
-
G
-
V
D
A
A
I
L
Y
K
D
I
M
T
P
L
P
S
I
G
V
D
V
E
I
K
N
G
I
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L
G
Q
I
D
--
P
-
E
--
Q
D
V
P
Y
----
V
L
E
T
I
K
L
L
V
N
E
Q
-
L
------
N
------
V
P
L
I
G
F
S
G
A
P
F
T
L
A
S
Y
M
T
E
G
G
P
S
K
N
Y
--
N
---
K
---
T
K
A
-
F
M
Y
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
Y
I
K
P
V
----
M
N
R
I
F
S
E
L
-
A
-
K
E
-------
N
----
V
---
P
L
I
M
F
G
V
G
A
S
H
L
A
G
D
W
H
D
L
P
--------
L
D
-
V
V
G
L
D
W
R
L
G
I
D
E
A
R
S
K
-
G
I
T
K
T
V
Q
G
N
L
D
P
S
I
L
L
A
P
W
E
V
I
E
Q
K
T
K
E
I
L
D
Q
G
-----
M
---
E
S
D
G
F
I
F
N
L
G
H
G
V
F
P
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
------
21
PsiBlast_CBE
94.77
41%
-115
- C2 -
4ZR8
5
?
B:
[12-358]
------
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
--
E
-
T
R
S
K
--
A
G
D
-
F
L
S
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
P
K
L
N
--
A
-
K
--
A
D
L
D
Y
----
V
M
N
A
V
S
T
I
R
S
A
L
-
G
G-----
Q
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
E
F
--
R
---
F
---
T
K
Q
-
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
F
S
L
N
Y
----
M
K
K
I
I
A
G
L
-
Q
-
R
E
-------
K
DG
R
R
I
---
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
---
I
T
T
G
-----
A
D
-
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
--
A
N
G
---
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
-------
3
PsiBlast_PDB
94.70
41%
-115
- C2 -
4WSH
8
DCUP_PSEAE
A:
[12-357]
------
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
--
A
-
T
R
A
K
--
A
-
G
D
F
M
S
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
P
Q
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
F
E
T
G
E
G
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
P
V
P
D
--
P
E
Q
--
D
-
L
G
Y
----
V
M
D
A
V
R
T
I
R
R
E
L
N
G
------
R
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
--
R
---
K
---
S
K
A
-
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
F
S
L
A
Y
----
M
R
K
I
V
D
G
L
I
R
-
E
H
-------
D
G
R
R
-
V
---
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
---------
G
A
E
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
G
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
-
P
A
A
I
R
A
E
V
A
R
I
----
L
A
A
Y
G
---
K
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
------
38
HHSearch
94.65
41%
-121
- C2 -
4EXQ
1
DCUP_BURTA
A:
[4-358]
-
S
M
A
Q
T
L
I
N
D
T
F
L
R
A
L
L
R
E
P
T
D
Y
T
P
I
W
L
M
R
Q
A
G
R
Y
L
P
E
Y
N
A
-
T
-
R
A
R
A
--
G
-
S
-
F
L
G
L
A
K
H
P
D
Y
A
T
E
V
T
L
Q
P
L
E
R
F
-
P
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
L
G
L
D
F
----
G
P
K
F
A
H
P
V
R
T
E
A
D
V
A
K
L
A
V
P
D
--
I
-
G
A-
T
-
L
G
Y
----
V
T
D
A
V
R
E
I
R
R
A
L
-
T
DGEGRQ
R
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
C
Y
M
V
E
G
G
---
G
S
--
D
---
D
F
R
T
V
K
S
-
M
A
Y
A
R
P
D
L
M
H
R
I
L
D
V
N
A
Q
A
V
A
A
Y
L
N
A
Q
I
E
A
G
A
Q
A
V
M
I
F
D
T
W
G
G
A
L
A
D
G
A
Y
Q
R
F
S
L
D
Y
----
I
R
R
V
V
A
Q
L
-
K
-
R
E
-------
H
DG
A
R
V
---
P
A
I
A
F
T
K
G
G
G
L
W
L
E
D
L
A
A
T
G
--------
V
D
-
A
V
G
L
D
W
T
V
N
L
G
R
A
R
E
R
V
A
G
R
V
A
L
Q
G
N
L
D
P
T
I
L
F
A
P
P
E
A
I
R
A
E
A
R
A
V
L
D
S
Y
-----
G
---
N
H
P
G
H
V
F
N
L
G
H
G
I
S
Q
F
T
P
P
E
H
V
A
E
L
V
D
E
V
H
R
H
------
25
PsiBlast_CBE
94.56
40%
-119
- C2 -
4EXQ
1
DCUP_BURTA
A:
[4-356]
-
S
M
A
Q
T
L
I
N
D
T
F
L
R
A
L
L
R
E
P
T
D
Y
T
P
I
W
L
M
R
Q
A
G
R
Y
L
P
E
Y
N
--
A
-
T
R
A
R
--
A
G
S
-
F
L
G
L
A
K
H
P
D
Y
A
T
E
V
T
L
Q
P
L
E
R
F
-
P
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
L
G
L
D
F
----
G
P
K
F
A
H
P
V
R
T
E
A
D
V
A
K
L
A
V
P
D
--
I
-
G
--
A
T
L
G
Y
----
V
T
D
A
V
R
E
I
R
R
A
L
-
T
------
D
GEGRQR
V
P
L
I
G
F
S
G
S
P
W
T
L
A
C
Y
M
V
E
G
G
G
S
D
D
F
--
R
---
T
---
V
K
S
-
M
A
Y
A
R
P
D
L
M
H
R
I
L
D
V
N
A
Q
A
V
A
A
Y
L
N
A
Q
I
E
A
G
A
Q
A
V
M
I
F
D
T
W
G
G
A
L
A
D
G
A
Y
Q
R
F
S
L
D
Y
----
I
R
R
V
V
A
Q
L
-
K
R
E
H
-------
D
G
A
R
-
V
---
P
A
I
A
F
T
K
G
G
G
L
W
L
E
D
L
--
A
A
T
G
V
D
-------
A
V
G
L
D
W
T
V
N
L
G
R
A
R
E
R
V
A
G
R
V
A
L
Q
G
N
L
D
P
T
I
L
F
A
P
P
E
A
I
R
A
E
A
R
A
V
L
D
S
-----
Y
G
---
N
H
P
G
H
V
F
N
L
G
H
G
I
S
Q
F
T
P
P
E
H
V
A
E
L
V
D
E
V
H
--------
40
HHSearch
94.36
40%
-116
- C2 -
4WSH
8
DCUP_PSEAE
A:
[10-357]
----
T
A
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
A
T
R
-
A
K
A
G
----
D
-
F
M
S
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
-
P
Q
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
F
E
T
G
E
G
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
P
V
P
D
--
P
-
E
Q-
D
-
L
G
Y
----
V
M
D
A
V
R
T
I
R
R
E
L
-
N
G-----
R
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
--
R
---
K
---
S
K
A
-
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
F
S
L
A
Y
----
M
R
K
I
V
D
G
L
-
I
-
R
E
HDG
R
---
R
----
V
---
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
G
--------
A
E
-
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
G
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
P
A
A
I
R
A
E
V
A
R
I
L
A
A
Y
-----
G
---
K
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
------
42
HHSearch
93.92
42%
-122
* C2 *
4ZR8
6
?
A:
[11-359]
-----
T
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
--
E
T
R
S
K
A
--
G
----
L
S
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
P
K
L
N
--
A
-
K
A-
D
-
L
D
Y
----
V
M
N
A
V
S
T
I
R
S
A
L
-
G
G-----
Q
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
------
G
GS
S
KEF
R
---
F
T
K
Q
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
F
S
L
N
Y
----
M
K
K
I
I
A
G
L
-
Q
-
R
E
KDG
R
---
R
----
I
---
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
--------
A
D
-
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
-----
Y
ANG
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
------
22
PsiBlast_CBE
93.26
41%
-113
- C2 -
4WSH
3
DCUP_PSEAE
B:
[12-357]
------
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
--
A
-
T
R
A
K
--
A
-
G
D
F
M
S
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
P
Q
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
------
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
P
V
P
D
--
P
E
Q
--
D
-
L
G
Y
----
V
M
D
A
V
R
T
I
R
R
E
L
N
G
------
R
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
--
R
---
K
---
S
K
A
-
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
F
S
L
A
Y
----
M
R
K
I
V
D
G
L
I
R
-
E
H
-------
D
G
R
R
-
V
---
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
---------
G
A
E
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
G
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
-
P
A
A
I
R
A
E
V
A
R
I
----
L
A
A
Y
G
---
K
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
------
1
PsiBlast_PDB
93.24
43%
-118
- C2 -
2INF
-
DCUP_BACSU
A:
[6-342]
------
T
F
N
E
T
F
L
K
A
A
R
G
E
K
A
D
H
T
P
V
W
Y
M
R
Q
A
G
R
S
Q
P
E
Y
R
--
K
-
L
K
E
K
--
Y
-
G
-
L
F
E
I
T
H
Q
P
E
L
C
A
Y
V
T
R
L
P
V
E
Q
Y
-
G
-
V
D
A
A
I
L
Y
K
D
I
M
T
P
L
P
S
I
G
V
D
V
E
I
K
N
G
I
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L
G
Q
I
D
--
P
-
E
--
Q
-
D
V
P
Y
---
V
L
E
T
I
K
L
L
V
N
E
Q
-
L
------
N
------
V
P
L
I
G
F
S
G
A
P
F
T
L
A
S
Y
M
T
E
G
G
P
S
K
N
Y
--
N
---
K
---
T
K
A
-
F
M
Y
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
Y
I
K
P
V
----
M
N
R
I
F
S
E
L
-
A
-
K
E
-------
N
----
V
---
P
L
I
M
F
G
V
G
A
S
H
L
A
G
D
W
H
D
L
P
L
--------
D
-
V
V
G
L
D
W
R
L
G
I
D
E
A
R
S
K
G
I
T
K
T
-
V
Q
G
N
L
D
P
S
I
L
L
A
P
W
E
V
I
E
Q
K
T
K
E
I
L
D
Q
G
M
E
--------
S
D
G
F
I
F
N
L
G
H
G
V
F
P
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
-------
27
Fugue
93.11
37%
-117
- C2 -
1URO
1
DCUP_HUMAN
A:
[10-366]
--
G
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
D
P
E
V
V
A
-
S
--
E
-
L
G
Y
----
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
----
I
R
D
V
A
K
Q
V
-
K
-
A
R
L
R
E
A
G
L
A
P
----
V
---
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
--------
G
Y
E
-
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
F
---------
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
4
PsiBlast_PDB
92.99
38%
-116
- C2 -
3CYV
-
DCUP_SHIFL
A:
[3-348]
-----
E
L
K
N
D
R
Y
L
R
A
L
L
R
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
K
--
A
-
T
R
A
Q
--
A
G
D
-
F
M
S
L
C
K
N
A
E
L
A
C
E
V
T
L
Q
P
L
R
R
Y
-
P
-
L
D
A
A
I
L
F
S
D
I
L
T
V
P
D
A
M
G
L
G
L
Y
F
E
A
G
E
G
P
R
F
T
S
P
V
T
C
K
A
D
V
D
K
L
P
I
P
D
--
P
-
E
D-
E
-
L
G
Y
----
V
M
N
A
V
R
T
I
R
H
E
L
K
G
------
E
------
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
A
F
--
T
---
V
---
I
K
K
-
M
M
Y
A
D
P
Q
A
L
H
A
L
L
D
K
L
A
K
S
V
T
L
Y
L
N
A
Q
I
K
A
G
A
Q
A
V
M
I
F
D
T
W
G
G
V
L
T
G
R
D
Y
Q
Q
F
S
L
Y
Y
----
M
H
K
I
V
D
G
L
-
L
-
R
E
-------
N
DG
R
R
V
---
P
V
T
L
F
T
K
G
G
G
Q
W
L
E
A
M
A
E
T
G
C
--------
D
-
A
L
G
L
D
W
T
T
D
I
A
D
A
R
R
R
V
G
N
K
V
A
L
Q
G
N
M
D
P
S
M
L
Y
A
P
P
A
R
I
E
E
E
V
A
T
I
L
-----
A
G
F
G
---
H
G
E
G
H
V
F
N
L
G
H
G
I
H
Q
D
V
P
P
E
H
A
G
V
F
V
E
A
V
H
R
L
------
20
PsiBlast_PDB
92.71
37%
-118
- C2 -
1R3S
1
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
41
HHSearch
92.41
37%
-117
- C2 -
1R3S
1
DCUP_HUMAN
A:
[11-360]
---
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
D
P
E
--
V
-
V
A
S
E
-
L
G
Y
----
V
F
Q
A
I
T
L
T
R
Q
R
L
-
A
G-----
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
----
I
R
D
V
A
K
Q
V
-
K
-
A
R
L
R
E
A
---
G
----
L
A
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
--------
Y
E
-
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
F
-----
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
------
17
PsiBlast_PDB
92.14
37%
-117
- C2 -
1R3V
2
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
E
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
15
PsiBlast_PDB
92.12
37%
-119
- C2 -
3GVV
-
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
Y
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
23
PsiBlast_CBE
91.97
37%
-117
- C2 -
1R3T
1
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
43
HHSearch
91.85
36%
-123
- C2 -
2EJA
1
DCUP_AQUAE
A:
[2-335]
------
P
K
N
D
L
L
L
R
S
L
R
G
E
P
I
G
R
F
P
V
W
L
M
R
Q
A
G
R
Y
M
P
E
Y
R
----
K
I
R
N
RV
K
-
N
-
F
L
E
L
C
K
N
V
D
L
A
T
E
I
S
L
L
P
L
K
I
L
-
G
-
V
D
A
I
I
I
F
S
D
I
L
V
P
L
E
P
L
G
V
K
V
E
F
V
E
G
E
G
P
K
L
----
S
W
S
G
K
V
S
D
L
K
K
Y
D
--
P
-
S
--
Q
-
N
A
Y
----
V
Y
E
I
I
K
R
V
K
E
A
Q
-
D
------
E
------
V
P
V
I
G
F
A
G
A
P
F
T
L
L
S
Y
L
I
E
G
G
A
S
K
D
F
--
K
---
S
---
T
K
L
-
F
M
W
E
N
P
K
E
Y
K
R
L
M
D
I
L
T
E
T
V
L
A
Y
L
K
E
Q
I
K
A
G
A
D
V
V
Q
I
F
D
S
W
V
N
N
L
S
L
E
D
Y
G
E
Y
V
Y
P
Y
----
V
N
Y
L
I
S
E
L
-
K
-
D
F
S------
D
----
T
---
P
V
I
Y
F
F
R
G
S
S
S
F
I
D
L
A
V
D
Y
R
--------
A
D
-
A
L
S
V
D
W
S
V
D
I
P
E
L
F
K
I
Y
D
--
K
G
F
Q
G
N
L
E
P
A
V
L
Y
A
S
E
E
V
I
E
E
K
T
L
G
L
L
R
R
I
-----
P
---
V
K
T
R
Y
V
F
N
L
G
H
G
L
A
P
D
M
E
L
E
K
V
K
Y
L
V
D
L
V
K
S
F
------
19
PsiBlast_PDB
91.80
37%
-115
- C2 -
1JPI
-
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
L
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
26
PsiBlast_CBE
91.74
35%
-125
- C2 -
2EJA
1
DCUP_AQUAE
A:
[8-335]
------------
L
R
S
L
R
G
E
P
I
G
R
F
P
V
W
L
M
R
Q
A
G
R
Y
M
P
E
Y
R
--
K
-
I
R
N
R
V-
K
-
N
-
F
L
E
L
C
K
N
V
D
L
A
T
E
I
S
L
L
P
L
K
I
L
-
G
-
V
D
A
I
I
I
F
S
D
I
L
V
P
L
E
P
L
G
V
K
V
E
F
V
E
G
E
G
P
K
L
S
----
W
S
G
K
V
S
D
L
K
K
Y
D
--
P
-
S
--
Q
-
N
A
Y
----
V
Y
E
I
I
K
R
V
K
E
A
Q
-
D
------
E
------
V
P
V
I
G
F
A
G
A
P
F
T
L
L
S
Y
L
I
E
G
G
A
S
K
D
F
--
K
---
S
---
T
K
L
-
F
M
W
E
N
P
K
E
Y
K
R
L
M
D
I
L
T
E
T
V
L
A
Y
L
K
E
Q
I
K
A
G
A
D
V
V
Q
I
F
D
S
W
V
N
N
L
S
L
E
D
Y
G
E
Y
V
Y
P
Y
----
V
N
Y
L
I
S
E
L
-
K
-
D
F
-------
S
D---
T
---
P
V
I
Y
F
F
R
G
S
S
S
F
I
D
L
A
V
D
Y
--------
R
A
D
-
A
L
S
V
D
W
S
V
D
I
P
E
L
F
K
--
I
Y
D
K
G
F
Q
G
N
L
E
P
A
V
L
Y
A
S
E
E
V
I
E
E
K
T
L
G
L
L
---
R
R
I
--
P
---
V
K
T
R
Y
V
F
N
L
G
H
G
L
A
P
D
M
E
L
E
K
V
K
Y
L
V
D
L
V
K
S
F
------
9
PsiBlast_PDB
91.47
37%
-117
- C2 -
1R3Q
2
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
10
PsiBlast_PDB
91.28
37%
-117
- C2 -
1R3Y
1
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
18
PsiBlast_PDB
90.97
37%
-115
- C2 -
1R3W
1
DCUP_HUMAN
A:
[13-359]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
F
M
V
E
G
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------
24
PsiBlast_CBE
90.63
37%
-117
- C2 -
2Q71
1
DCUP_HUMAN
A:
[3-349]
-----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
--
E
-
T
R
A
A
--
Q
-
D
-
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
--
D
--
P
-
E
--
V
-
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
------
R
------
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
R
G
G
S
S
T
M
--
A
---
Q
---
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
-
R
-
E
A
-------
G
L
A
P
-
V
---
P
M
I
I
F
A
---
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
------
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
------
D
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
-------