@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2701c: (2016-05-13 )
MTRPDNEPARLRSVAENLAAEAAAFVRGRRAEVFGISRAGDGDGAVRAKSSPTDPVTVVDTDTERLLRDRLAQLRPGDPILGEEGGGPADVTATPSDRVTWVLDPIDGTVNFVYGIPAYAVSIGAQVGGITVAGAVADVAARTVYSAATGLGAHLTDERGRHVLRCTGVDELSMALLGTGFGYSVRCREKQAELLAHVVPLVRDVRRIGSAALDLCMVAAGRLDAYYEHGVQVWDCAAGALIAAEAGARVLLSTPRAGGAGLVVVAAAPGIADELLAALQRFNGLEPIPD
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80...----------.....90.-------------------------------------------------.......100-------------------------------------.........110....-...120.......130.......140---------------.--..----------------.....150....-------...160------.---........170.......180-----.....-.-.-190.......-.-200---........210.......220......------.------230.........240.....--..250-------....--....----------.260-------.-.----..-.-.-.---.270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRPDN
E
P
A
R
L
R
S
V
A
E
N
L
A
A
E
A
A
A
F
V
RGR
R
A
E
V
F
G
I
S
RAGDGDG
A
V
RAKSSPTD
P
V
T
V
VDT
D
T
E
R
L
L
R
D
R
L
A
QLRPGDPILGEE----------GGGPADVT-------------------------------------------------ATPSD
R
V
T
---------------------------------------
W
V
L
DPIDG
T
V
N
F
V
YGI-
P
A
Y
A
V
S
IGAQVG
G
I
T
V
A
G
A
V
A
D
V
A
A
----------------
R
--
T
V
----------------
Y
S
A
ATGLGAHLT-------DERG--------
R
---
H
V
L
R
CT
G
V
D
E
L
S
M
A
L
LGTGFG-----
Y
S
V
R
C-
R
-
E
-
K
-
Q
A
E
L
L
A
H
V
-
V
-
P
L
----
V
R
D
V
R
R
I
G
S
A
A
L
D
L
C
M
V
AAG
R
L
D
A
Y
Y
E------H------G--
V
Q
V
W
DCAAGA
L
I
A
AEAG--
A
R
V
---------
L
L
ST--PRAG----------GA
G
--------
L
-
V
----
V
V
-A-A-A---PG
I
A
D
E
L
L
A
A
L
Q
R
FNGLEPIPD
1
PsiBlast_PDB
99.31
100%
-127
- C3 -
2Q74
-
SUHB_MYCTU
A:
[5-286]
----
D
N
E
P
A
R
L
R
S
V
A
E
N
L
A
A
E
A
A
A
F
V
R
G
R
R
A
E
V
F
-------------------
D
P
V
T
V
V
D
T
D
T
E
R
L
L
R
D
R
L
A
Q
L
R
P
G
D
P
I
L
G
E
E
----------
G
-------------------------------------------------------------
R
V
T
---------------------------------------
W
V
L
D
P
I
D
G
T
V
N
F
V
Y
G
I
-
P
A
Y
A
V
S
I
G
A
Q
V
G
G
I
T
V
A
G
A
V
A
D
V
A
A
----------------
R
--
T
V
----------------
Y
S
A
A
T
G
L
G
A
H
L
T
-------
D
E
R
G
--------
R
---
H
V
L
R
C
T
G
V
D
E
L
S
M
A
L
L
G
T
G
F
G
-----
Y
S
V
R
C
-
R
-
E
-
K
-
Q
A
E
L
L
A
H
V
-
V
-
P
L
----
V
R
D
V
R
R
I
G
S
A
A
L
D
L
C
M
V
A
A
G
R
L
D
A
Y
Y
E
------
H
------
G
--
V
Q
V
W
D
C
A
A
G
A
L
I
A
A
E
A
G
--
A
R
V
---------
L
L
S
------------------
A
G
--------
L
-
V
----
V
V
-
A
-
A
-
A
---
P
G
I
A
D
E
L
L
A
A
L
Q
R
F
N
G
L
E
----
47
HHSearch
96.62
98%
-124
- C3 -
2Q74
-
SUHB_MYCTU
A:
[5-286]
----
D
N
E
P
A
R
L
R
S
V
A
E
N
L
A
A
E
A
A
A
F
V
R
G
R
R
A
E
V
-
F
------------------
D
P
V
T
V
V
D
T
D
T
E
R
L
L
R
D
R
L
A
Q
L
R
P
G
D
P
I
L
G
E
E
----------
G
-------------------------------------------------------------
R
V
T
---------------------------------------
W
V
L
D
P
I
D
G
T
V
N
F
V
Y
G
I
-
P
A
Y
A
V
S
I
G
A
Q
V
G
G
I
T
V
A
G
A
V
A
D
V
A
A
----------------
R
--
T
V
----------------
Y
S
A
A
T
G
L
G
A
H
L
T
-------
D
E
R
G
--------
R
---
H
V
L
R
C
T
G
V
D
E
L
S
M
A
L
L
G
T
G
F
G
-----
Y
S
V
R
C
-
R
-
E
-
K
-
Q
A
E
L
L
A
H
V
-
V
-
P
L
----
V
R
D
V
R
R
I
G
S
A
A
L
D
L
C
M
V
A
A
G
R
L
D
A
Y
Y
E
------
H
------
G
--
V
Q
V
W
D
C
A
A
G
A
L
I
A
A
E
A
G
--
A
R
V
---------
L
L
S
-------------------
A
--------
G
-
L
----
V
V
V
A
-
A
-
A
---
P
G
I
A
D
E
L
L
A
A
L
Q
R
F
N
G
L
E
----
51
HHSearch
70.28
31%
-96
- C3 -
3LV0
1
?
A:
[8-265]
--------
S
A
V
M
N
V
M
V
Q
A
A
M
K
A
G
R
S
L
V
R
D
Y
G
E
V
--------
Q
N
L
Q
V
S
L
K
-
G
P
A
D
Y
V
S
Q
A
D
R
K
A
E
K
I
I
F
N
E
L
S
K
A
R
P
K
F
G
F
L
M
E
E
----------
S
E
E
I
I
-----------------------------------------------------
G
E
D
S
Q
H
R
---------------------------------------
F
I
V
D
P
L
D
G
T
T
N
F
L
H
G
I
-
P
F
F
A
V
S
I
A
L
E
S
Q
G
K
I
V
A
G
V
I
Y
N
P
I
N
----------------
D
--
E
L
----------------
F
T
A
E
R
G
S
G
A
F
F
N
-------
D
R
R
C
---------------
R
V
S
A
R
R
R
L
E
D
C
V
I
A
T
G
M
P
-----
H
L
--
P
G
H
-
G
-
T
-
Y
L
I
E
L
R
N
V
-
M
-
A
E
----
V
S
G
I
R
R
F
G
T
A
A
L
D
L
A
Y
V
A
A
G
R
T
D
G
F
W
E
------
D
------
N
--
L
Q
I
W
D
M
A
A
G
I
L
M
V
R
E
A
G
--
G
F
V
---------
T
D
K
E
--
G
G
N
D
----------
I
F
R
--------
K
-
K
N
---
I
I
-
A
-
G
-
N
---
E
H
I
R
I
K
L
E
R
A
L
K
K
---------
15
PsiBlast_PDB
68.11
34%
-105
- C3 -
2CZI
3
IMPA2_HUMAN
A:
[45-292]
-----------------------------------
I
R
K
A
L
T
E
E
----
T
K
T
S
A
A
D
L
V
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
A------------
K
C
V
L
T
-------------------------------------------------
H
S
P
----
T
---------------------------------------
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
-
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
H
C
T
E
----------------
E
--
R
L
----------------
Y
T
G
R
R
G
R
G
A
F
C
N
-------
G
Q
R
---------------
L
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
I
G
PKRD
P
A
T
L
K
L
-
F
-
L
-
S
-
N
M
E
R
L
L
H
A
-
K
-------
A
H
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
------
F
------
G
--
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
--
G
I
V
---------
I
D
T
S
GG
P
L
D
L
----------
M
A
C
--------
R
-
V
----
V
A
-
A
-
S
-
T
---
R
E
M
A
M
L
I
A
Q
A
L
Q
T
I
N
-------
56
HHSearch
67.25
31%
-85
- C3 -
2BJI
3
IMPA1_BOVIN
A:
[3-269]
-----
D
P
W
Q
E
C
M
D
Y
A
V
T
L
A
G
Q
A
G
E
V
V
R
E
A
L
K
N
E
----------
M
N
I
M
V
K
S
S
P
A
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
T
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
G
F
-
P
F
V
A
V
S
I
G
F
V
V
N
K
K
M
E
F
G
I
V
Y
S
C
L
E
----------------
D
--
K
M
----------------
Y
T
G
R
K
G
K
G
A
F
C
N
-------
G
Q
K
L
---------------
Q
V
S
H
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
R
T
P
-
E
-
T
V
R
I
I
L
S
N
I
E
R
L
-
L
C
L
P
----
I
H
G
I
R
G
V
G
T
A
A
L
N
M
C
L
V
A
A
G
A
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
L
D
V
T
--
G
G
P
F
----------
D
L
M
--------
S
-
R
R
---
V
I
-
A
S
S
-
N
---
K
T
L
A
E
R
I
A
K
E
I
Q
I
I
--------
57
HHSearch
67.19
31%
-90
- C3 -
2QFL
2
SUHB_ECOLI
A:
[3-261]
---------
P
M
L
N
I
A
V
R
A
A
R
K
A
G
N
L
I
A
K
N
Y
E
T
P
--------
D
A
V
E
A
S
Q
K
-
G
S
N
D
F
V
T
N
V
D
K
A
A
E
A
V
I
I
D
T
I
R
K
S
Y
P
Q
H
T
I
I
T
E
E
----------
S
G
E
L
E
-----------------------------------------------------
G
T
D
Q
D
V
Q
---------------------------------------
W
V
I
D
P
L
D
G
T
T
N
F
I
K
R
L
-
P
H
F
A
V
S
I
A
V
R
I
K
G
R
T
E
V
A
V
V
Y
D
P
M
R
----------------
N
--
E
L
----------------
F
T
A
T
R
G
Q
G
A
Q
L
N
-------
G
Y
R
L
---------------
R
G
S
T
A
R
D
L
D
G
T
I
L
A
T
G
F
P
-----
F
K
A
K
Q
Y
A
-
T
-
T
-
Y
I
N
I
V
G
K
L
-
F
-
N
E
----
C
A
D
F
R
A
T
G
S
A
A
L
D
L
A
Y
V
A
A
G
R
V
D
G
F
F
E
------
I
------
G
--
L
R
P
W
D
F
A
A
G
E
L
L
V
R
E
A
G
--
G
I
V
---------
S
D
F
T
--
G
G
H
N
----------
Y
M
L
--------
T
-
G
N---
I
V
-
A
-
G
-
N
---
P
R
V
V
K
A
M
L
A
N
M
R
D
E
L
-------
49
HHSearch
67.14
30%
-94
- C3 -
5DW8
4
?
A:
[11-267]
----------
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
-------------------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
----------
G
H
G
H
D
----------------------------------------------------
I
D
T
S
K
G
T
V
---------------------------------------
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
-
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
----------------
D
--
V
L
----------------
Y
H
A
K
V
G
E
G
A
Y
R
G
-------
S
Q
P
L
---------------
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
I
N
P
N
-----
W
L
T
K
----
P
-
I
-
L
G
E
I
F
K
E
I
-
V
-
N
D
----
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
------
P
------
R
--
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
--
G
Q
A
---------
S
N
L
L
--
G
E
P
L
----------
T
I
S
--------
G
P
N
S
---
I
L
-
V
-
G
-
N
---
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
H
H
------
52
HHSearch
66.09
28%
-101
- C3 -
2P3N
1
BSUHB_THEMA
A:
[3-248]
----------
R
L
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
----------
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
----------
G
I
F
E
--------------------------------------------------------
K
G
D
R
L
---------------------------------------
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
-
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
----------------
N
--
E
T
----------------
L
Y
A
E
E
G
S
G
A
F
F
N
-------
G
E
R
I
---------------
R
V
S
E
N
A
S
L
E
E
C
V
G
S
T
G
S
Y
-----
V
D
--
F
-------
T
G
K
F
I
E
R
M
-
E
-
K
R
----
T
R
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
------
W
------
R
--
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
--
G
M
V
---------
T
D
F
S
--
G
K
E
A
----------
N
A
F
--------
S
-
K
N
---
F
I
-
F
-
S
-
N
---
G
L
I
H
D
E
V
V
K
V
V
N
E
---------
65
HHSearch
65.27
22%
-100
- C3 -
1KA1
4
MET22_YEAST
A:
[2-351]
------
A
L
E
R
E
L
L
V
A
T
Q
A
V
R
K
A
S
L
L
T
K
R
I
Q
S
E
V
--
I
-
S
--
H
K
D
S
T
T
I
T
K
-
N
D
N
S
P
V
T
T
G
D
Y
A
A
Q
T
I
I
I
N
A
I
K
S
N
F
P
D
D
K
V
V
G
E
E
----------
S
S
S
G
L
S
D
A
F
V
S
G
I
L
N
E
I
K
A
N
D
E
V
Y
N
K
N
Y
K
K
D
DFLFTNDQFPLKS
L
E
D
V
R
Q
I
I
D
FGNY
E
G
G
R
K
G
R
F
---------------------------------------
W
C
L
D
P
I
D
G
T
K
G
F
L
R
G
E
--
Q
F
A
V
C
L
A
L
I
V
D
G
V
V
Q
L
G
C
I
G
C
P
N
L
VLSSYG
A
Q
D
L
KGHES
F
G
--
Y
I
----------------
F
R
A
V
R
G
L
G
A
F
Y
S
-------
P
S
S
D
--------
A
E
S
W
T
K
I
H
V
R
H
L
K
D
T
K
D
M
I
T
L
E
G
V
E
-----
K
G
H
S
S
-
H
-
D
-
E
-
Q
T
A
I
K
N
K
L
---
N
I
-----
S
K
S
L
H
L
D
S
-
Q
A
K
Y
C
L
L
A
L
G
L
A
D
V
Y
L
R
------
L
P
IKLS
Y
Q
--
E
K
I
W
D
H
A
A
G
N
V
I
V
H
E
A
G
--
G
I
H
---------
T
D
A
M
E-
D
V
P
L
----------
D
F
G
NGRTLAT-
K
-
G
----
V
I
-
A
S
S
G
P
---
R
E
L
H
D
L
V
V
S
T
S
C
D
V
--------
48
HHSearch
64.82
25%
-95
- C3 -
4N81
1
?
A:
[3-258]
----
R
S
A
Y
E
D
D
I
R
L
A
H
R
L
A
D
V
A
A
D
I
I
R
P
F
F
R
A
P
----------
L
T
I
D
L
K
-
A
D
H
S
P
V
T
K
A
D
R
G
A
E
Q
A
M
R
A
I
L
E
Q
E
R
P
E
D
G
I
F
G
E
--------------
S
R
------------------------------------------------------
P
D
A
R
R
L
---------------------------------------
W
V
L
D
P
I
D
G
T
R
A
F
I
G
G
R
-
A
S
F
G
T
L
I
A
L
V
E
D
G
R
P
V
L
G
I
I
N
Q
P
I
H
----------------
Q
--
E
R
----------------
W
V
G
V
K
D
L
P
T
S
F
N
-------
G
E
V
I
---------------
H
T
R
S
C
P
A
L
D
H
A
L
L
A
T
T
S
P
-----
W
L
F
E
K
-
E
-----
G
E
V
H
F
D
K
I
---
R
L
----
K
C
R
D
T
L
L
G
G
D
C
Y
N
Y
G
L
L
S
L
G
H
C
D
L
V
V
E
------
Q
------
G
--
L
K
F
Y
D
F
A
A
L
V
P
I
V
E
G
A
G
--
G
I
M
---------
R
D
W
Q
--
N
R
P
L
----------
N
K
N
--------
S
V
G
E---
V
I
-
A
A
G
-
D
---
H
H
L
I
E
P
A
L
S
A
M
E
----------
55
HHSearch
64.52
32%
-101
- C3 -
2FVZ
-
IMPA2_HUMAN
A:
[17-277]
--------
E
E
C
F
Q
A
A
V
Q
L
A
L
R
A
G
Q
I
I
R
K
A
L
T
E
E
-----------------------
T
E
T
D
H
L
V
E
D
L
I
I
S
E
L
R
E
R
F
P
S
H
R
F
I
A
E
E
----------
A
------
K
-------------------------------------------------
C
V
L
T
H
S
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
C
N
F
V
H
R
F
-
P
T
V
A
V
S
I
G
F
A
V
R
Q
E
L
E
F
G
V
I
Y
H
C
T
E
----------------
E
--
R
L
----------------
Y
T
G
R
R
G
R
G
A
F
C
N
-------
G
Q
R
L
---------------
R
V
S
G
E
T
D
L
S
K
A
L
V
L
T
E
I
G
-----
P
K
R
D
P
-
A
-
T
L
K
L
F
L
S
N
M
E
R
L
L
H
-
A
K
----
A
H
G
V
R
V
I
G
S
S
T
L
A
L
C
H
L
A
S
G
A
A
D
A
Y
Y
Q
------
F
------
G
--
L
H
C
W
D
L
A
A
A
T
V
I
I
R
E
A
G
--
G
I
V
---------
I
D
T
S
--
G
G
P
L
----------
D
L
M
--------
A
-
C
R
---
V
V
-
A
A
S
-
T
---
R
E
M
A
M
L
I
A
Q
A
L
-----------
54
HHSearch
61.32
22%
-92
- C3 -
5EQ7
2
?
A:
[13-276]
------
Q
L
N
H
F
S
D
V
A
N
K
A
A
N
A
A
G
D
V
I
R
K
Y
F
R
K
N
---------
N
F
--------
L
S
P
V
T
I
A
D
Q
S
A
E
E
A
M
V
S
V
I
L
D
N
F
P
S
H
A
V
Y
G
E
E
----------
K
G
W
R
C
--
K
--------------------------------------------------
Q
D
S
A
D
Y
V
---------------------------------------
W
V
L
D
P
I
D
G
T
K
S
F
I
T
G
--
P
L
F
G
T
L
I
A
L
L
Q
N
G
T
P
I
L
G
I
I
D
Q
P
V
L
----------------
K
--
E
R
----------------
W
I
G
I
T
G
K
R
T
T
L
N
-------
G
Q
E
V
---------------
S
T
R
T
C
A
D
L
S
Q
A
Y
L
Y
T
T
S
P
-----
H
L
F
S
G
-
D
-----
A
E
E
A
F
I
R
V
---
R
D
----
K
V
K
I
P
L
Y
G
C
D
C
Y
A
Y
A
L
L
S
S
G
F
V
D
L
V
V
E
------
S
------
G
--
L
K
P
Y
D
F
L
A
L
I
P
V
I
E
G
S
G
--
G
V
I
---------
T
D
W
K
--
G
H
Q
L
----------
R
W
E
ASPLSIA
T
S
-
F
N
---
V
V
-
A
A
G
-
D
---
K
Q
I
H
Q
Q
A
L
D
S
L
Q
----------
63
HHSearch
60.18
21%
-92
- C3 -
4O7I
2
?
A:
[3-314]
-------
F
D
K
E
L
A
L
A
L
E
I
V
Q
V
S
C
K
I
T
T
S
V
A
E
H
T
--------
L
T
D
Q
T
Q
I
K
-
N
D
K
S
P
V
T
V
G
D
Y
S
V
Q
A
Y
V
N
K
K
I
H
E
T
F
P
E
D
Q
I
V
A
E
E
----------
D
T
K
T
I
P
E
D
I
F
A
K
V
C
K
H
V
Q
I
Y
SDMK
D
D
E
I
R
K
S
I
D
LGN---------------------
S
T
G
G
K
G
R
H
---------------------------------------
W
V
L
D
P
I
D
G
T
L
G
F
L
R
R
--
E
Q
Y
A
V
C
L
A
F
M
I
D
G
D
I
K
V
G
V
L
G
C
P
N
F
----------------
E
G
G
L
I
----------------
V
A
A
Q
K
G
C
G
A
K
M
F
S
VNDIK
N
G
K
D
I
---------------
H
V
S
T
T
P
K
T
S
D
M
C
F
C
E
S
V
E
-----
V
S
H
T
D
-
Q
-
S
-
R
-
S
K
T
I
T
E
R
L
-
Q
-
V
T
----
K
P
P
V
R
-
M
D
S
-
Q
C
K
Y
M
A
I
A
S
G
R
A
D
V
Y
L
R
------
L
P
RNLS
Y
Q
--
E
K
I
W
D
H
A
A
G
Y
L
I
V
K
E
A
G
--
G
K
V
---------
T
D
I
Y
--
G
N
D
L
----------
D
F
S
LGRTLCN-
N
-
H
G
---
I
V
-
A
-
S
-
N
---
G
I
L
H
E
E
T
V
N
V
V
K
D
V
L
S
------
72
Fugue
60.00
21%
-90
- C3 -
1QGX
6
MET22_YEAST
A:
[2-355]
------
A
L
E
R
E
L
L
V
A
T
Q
A
V
R
K
A
S
L
L
T
K
R
I
Q
S
E
V
I
S
------
H
K
D
S
T
T
I
T
K
N
D
N
S
P
V
T
T
G
D
Y
A
A
Q
T
I
I
I
N
A
I
K
S
N
F
P
D
D
K
V
V
G
E
E
SSSGLS
D
A
F
V
S
G
I
L
N
E
I
K
-------------------------------------------------
A
N
D
E
V
Y
N
K
N
Y
K
K
D
DFLFTNDQFPLKS
L
E
D
V
R
Q
I
I
D
FGNYEGGR
K
G
R
F
W
C
L
D
P
I
D
G
T
K
G
F
L
R
G
--
E
Q
F
A
V
C
L
A
L
I
V
D
G
V
V
Q
L
G
C
I
G
C
P
N
L
----------------
V
--
L
S
SYG
A
Q
D
L
KGHES
F
G
Y
I
F
R
A
V
R
G
L
G
A
F
Y
S
PSS----
D
A
E
S
--------
W
---
T
K
I
H
V
R
H
L
K
D
T
K
D
M
I
T
L
E
G
V
E
-----
K
G
H
S
S
-
H
-
D
-
E
-
Q
T
A
I
K
N
K
L
----
N
----
I
S
K
S
L
H
L
D
S
Q
-
A
K
Y
C
L
L
A
L
G
L
A
D
V
Y
L
R
L
P
IKLS
Y
------
Q
--
E
K
I
W
D
H
A
A
G
N
V
I
V
H
E
A
G
--
G
I
H
---------
T
D
A
M
--
E
D
V
P
LDFGNGRTLA
T
K
G
--------
V
-
I
----
A
S
-
S
-
G
-
P
---
R
E
L
H
D
L
V
V
S
T
S
C
D
V
I
Q
S
R
----
58
HHSearch
59.80
23%
-93
- C3 -
1VDW
2
?
A:
[2-253]
------
S
V
K
T
W
R
K
I
A
I
D
I
I
R
D
F
D
H
N
I
M
P
L
F
G
N
P
-
K
------
A
S
E
T
I
S
I
------
E
T
K
V
V
D
K
V
A
E
N
I
I
I
S
K
F
K
D
--
L
G
V
N
V
V
S
E
E
----------
I
G
R
I
D
------------------------------------------------------
Q
G
S
D
Y
T
---------------------------------------
V
V
V
D
P
L
D
G
S
Y
N
F
I
N
G
I
-
P
F
F
A
V
S
V
A
I
F
H
E
K
D
P
I
Y
A
F
I
Y
E
P
I
V
----------------
E
--
R
L
----------------
Y
E
G
I
P
G
K
G
S
Y
L
N
-------
G
E
K
I
---------------
K
V
R
E
L
A
E
K
--
P
S
I
S
F
Y
-
T
-----
K
G
-
K
------------
G
T
K
I
-
I
-
D
K
----
V
K
R
T
R
T
L
G
A
I
A
L
E
L
A
Y
L
A
R
G
A
L
D
A
V
V
D
------
I
------
R
NY
L
R
P
T
D
I
A
A
G
V
V
I
A
R
E
A
G
--
A
I
V
---------
K
D
L
D
--
G
K
D
V
----------
E
I
T
FSAT
E
---
K
-
V
N
---
I
I
-
A
-
A
N
N
---
E
E
L
L
E
T
I
L
R
S
I
E
----------
62
HHSearch
59.27
24%
-83
- C3 -
1JP4
6
BPNT1_RAT
A:
[5-305]
----
H
N
V
L
M
R
L
V
A
S
A
Y
S
I
A
Q
K
A
G
T
I
V
R
C
V
I
A
E
G
---------
D
L
G
I
V
Q
K
T
S
A
T
D
L
Q
T
K
A
D
R
M
V
Q
M
S
I
C
S
S
L
S
R
K
F
P
K
L
T
I
I
G
E
E
----------
D
L
P
--
E
V
D
QELIEDGQS
E
E
I
L
K
QPCPSQYS---------------------------
A
I
K
E
E
D
L
V
---------------------------------------
V
W
V
D
P
V
D
G
T
K
E
Y
T
E
G
L
L
D
N
V
T
V
L
I
G
I
A
Y
E
G
K
A
I
A
G
I
I
N
Q
P
Y
Y
NYQAGPDAV
L
------
G
--
R
T
----------------
I
W
G
V
L
G
L
G
A
F
G
F
-------
Q
L
K
E
-----------------
A
P
---
A
G
K
H
I
I
T
T
T
R
S
-----
H
S
N
K
L
-------
V
T
D
C
I
A
A
M
----
N
----
P
D
N
V
L
R
V
G
G
A
G
N
K
I
I
Q
L
I
E
G
K
A
S
A
Y
V
F
------
A
SP----
G
--
C
K
K
W
D
T
C
A
P
E
V
I
L
H
A
V
G
--
G
K
L
---------
T
D
I
H
--
G
N
P
L
----------
Q
Y
D
KEVKHMN-
S
-
A
G
---
V
L
-
A
-
A
-
L
RN
Y
E
Y
Y
A
S
R
V
P
E
S
V
K
S
A
--------
14
PsiBlast_PDB
58.97
33%
-78
- C3 -
3LV0
1
?
A:
[42-265]
---------------------------------------------------
P
A
D
Y
V
S
Q
A
D
R
K
A
E
K
I
I
F
N
E
L
S
K
A
R
P
K
F
G
F
L
M
E
E
-------------
S
E
E
I
I
-------------------------------------------------
G
E
D
S
Q
H
-
R
---------------------------------------
F
I
V
D
P
L
D
G
T
T
N
F
L
H
G
I
-
P
F
F
A
V
S
I
A
L
E
S
Q
G
K
I
V
A
G
V
I
Y
N
P
I
N
----------------
D
--
E
L
----------------
F
T
A
E
R
G
S
G
A
F
F
N
-------
D
R
R
C
R
V
S
ARRRL
E
---
D
C
V
I
A
T
G
M
P
H
L
--
P
G
H
G
T
--------
Y
L
I
E
L
-
R
-
N
-
V
-
M
A
E
--------------
V
S
G
I
R
R
F
G
T
A
A
L
D
L
A
Y
V
A
A
G
R
T
D
G
F
W
E
------
D
------
N
--
L
Q
I
W
D
M
A
A
G
I
L
M
V
R
E
A
G
--
G
F
V
------------
T
--
D
K
E
G
----------
G
N
D
--------
I
-
F
RKK
N
I
I
-
A
-
G
-
N
---
E
H
I
R
I
K
L
E
R
A
L
K
K
---------
34
PsiBlast_CBE
58.39
33%
-79
- C3 -
3LV0
2
?
B:
[42-265]
---------------------------------------------------
P
A
D
Y
V
S
Q
A
D
R
K
A
E
K
I
I
F
N
E
L
S
K
A
R
P
K
F
G
F
L
M
E
E
-------------
S
E
E
I
I
-------------------------------------------------
G
E
D
S
Q
H
-
R
---------------------------------------
F
I
V
D
P
L
D
G
T
T
N
F
L
H
G
I
-
P
F
F
A
V
S
I
A
L
E
S
Q
G
K
I
V
A
G
V
I
Y
N
P
I
N
----------------
D
--
E
L
----------------
F
T
A
E
R
G
S
G
A
F
F
N
-------
D
R
R
C
R
V
S
ARRRL
E
---
D
C
V
I
A
T
G
M
P
H
L
--
P
G
H
G
T
--------
Y
L
I
E
L
-
R
-
N
-
V
-
M
A
E
--------------
V
S
G
I
R
R
F
G
T
A
A
L
D
L
A
Y
V
A
A
G
R
T
D
G
F
W
E
------
D
------
N
--
L
Q
I
W
D
M
A
A
G
I
L
M
V
R
E
A
G
--
G
F
V
------------
T
--
D
K
E
G
----------
G
N
D
--------
I
-
F
RKK
N
I
I
-
A
-
G
-
N
---
E
H
I
R
I
K
L
E
R
A
L
K
K
---------
13
PsiBlast_PDB
58.35
34%
-84
- C3 -
2QFL
2
SUHB_ECOLI
A:
[32-262]
-----------------------------------------------
S
Q
K
G
S
N
D
F
V
T
N
V
D
K
A
A
E
A
V
I
I
D
T
I
R
K
S
Y
P
Q
H
T
I
I
T
E
E
----------
S
G
---
E
L
E
-------------------------------------------------
G
T
D
Q
D
-
V
Q
---------------------------------------
W
V
I
D
P
L
D
G
T
T
N
F
I
K
R
L
-
P
H
F
A
V
S
I
A
V
R
I
K
G
R
T
E
V
A
V
V
Y
D
P
M
R
----------------
N
--
E
L
----------------
F
T
A
T
R
G
Q
G
A
Q
L
N
-------
G
Y
R
---------------
L
R
G
S
T
A
R
D
L
D
G
T
I
L
A
T
G
F
P
-----
F
K
A
K
Q
-
Y
A
T
-
T
-
Y
I
N
I
V
G
K
L
-
F
-
N
E
----
C
A
D
F
R
A
T
G
S
A
A
L
D
L
A
Y
V
A
A
G
R
V
D
G
F
F
E
------
I
------
G
--
L
R
P
W
D
F
A
A
G
E
L
L
V
R
E
A
G
--
G
I
V
S
D
FTGGHNY
M
L
T
G
--
N
I
V
A
----------
G
N
P
--------
R
-
V
----
V
K
-
A
-
M
-
L
---
A
N
M
R
D
E
L
S
--------------
70
Fugue
58.20
25%
-87
- C3 -
1DK4
4
BSUHB_METJA
A:
[1-252]
--------
M
K
W
D
E
I
G
K
N
I
A
K
E
I
E
K
E
I
L
P
Y
F
G
R
K
D
K
S
Y
--------
V
V
G
T
S
P
S
G
D
E
T
E
I
F
D
K
I
S
E
D
I
A
L
K
Y
L
K
S
--
L
N
V
N
I
V
S
E
E
----------
L
G
-----
V
-------------------------------------------------
I
D
N
S
S
E
W
T
---------------------------------------
V
V
I
D
P
I
D
G
S
F
N
F
I
N
G
I
-
P
F
F
A
F
C
F
G
V
F
K
N
N
E
P
Y
Y
G
L
T
Y
E
F
L
T
----------------
K
--
S
F
----------------
Y
E
A
Y
K
G
K
G
A
Y
L
N
-------
G
R
K
---------------
I
K
V
K
D
F
N
P
N
N
I
V
I
S
Y
Y
P
S
------------------
K
K
I
D
L
E
K
L
-
R
-
N
K
----
V
K
R
V
R
I
F
G
A
F
G
L
E
M
C
Y
V
A
K
G
T
L
D
A
V
F
D
VR----
P
------
K
--
V
R
A
V
D
I
A
S
S
Y
I
I
C
K
E
A
G
--
A
L
I
TDENGDE--
L
K
F
D
--
L
N
A
T
----------
D
R
L
--------
N
-
I
----
I
V
-
A
-
N
-
S
---
K
E
M
L
D
I
I
L
D
L
L
-----------
32
PsiBlast_CBE
57.33
34%
-80
- C3 -
4AS5
9
IMPA1_MOUSE
B:
[23-236]
-----------------------------------
I
R
E
A
L
K
N
E
M
D
V
M
I
K
S
S
P
A
D
L
V
T
V
T
D
Q
K
V
E
K
M
L
M
S
S
I
K
E
K
Y
P
C
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
K
T
-------------------------------------------------
V
F
-
T
E
Q
P
T
---------------------------------------
W
V
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
L
V
N
K
E
M
E
F
G
I
V
Y
S
C
V
E
----------------
D
--
K
M
----------------
Y
T
G
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
K
-
P
-
E
-
T
-
L
R
I
V
L
S
N
M
-
E
-
K
L
CSIP
I
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
M
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
5
PsiBlast_PDB
54.31
33%
-84
- C3 -
1IMA
2
IMPA1_HUMAN
A:
[23-236]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
F
C
I
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
10
PsiBlast_PDB
54.19
33%
-80
- C3 -
4AS4
8
IMPA1_HUMAN
A:
[23-236]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
F
C
I
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
3
PsiBlast_PDB
54.12
33%
-83
- C3 -
2HHM
2
IMPA1_HUMAN
A:
[22-235]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
F
C
I
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
4
PsiBlast_PDB
53.90
33%
-85
- C3 -
1AWB
5
IMPA1_HUMAN
A:
[22-235]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
F
C
I
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
6
PsiBlast_PDB
53.89
33%
-80
- C3 -
1IMB
2
IMPA1_HUMAN
A:
[23-236]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
F
C
I
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
28
PsiBlast_CBE
53.77
33%
-80
- C3 -
1IMB
2
IMPA1_HUMAN
B:
[23-236]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
FCIP
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
22
PsiBlast_CBE
53.42
33%
-81
- C3 -
2HHM
2
IMPA1_HUMAN
B:
[22-235]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
FCIP
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
29
PsiBlast_CBE
52.95
33%
-82
- C3 -
1IMA
2
IMPA1_HUMAN
B:
[23-236]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
FCIP
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
24
PsiBlast_CBE
52.80
33%
-77
- C3 -
4AS4
8
IMPA1_HUMAN
B:
[23-236]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
FCIP
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
23
PsiBlast_CBE
52.70
33%
-82
- C3 -
1AWB
6
IMPA1_HUMAN
B:
[22-235]
-----------------------------------
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
----------
S
V
A
A
G
E
-
K
-------------------------------------------------
S
I
L
T
D
N
P
T
---------------------------------------
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
-
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
----------------
G
--
K
M
----------------
Y
T
A
R
K
G
K
G
A
F
C
N
-------
G
Q
K
---------------
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
-----
S
S
-
R
T
-
P
-
E
-
T
-
V
R
M
V
L
S
N
M
-
E
-
K
L
FCIP
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
------
M
------
G
--
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
--
G
V
L
---------
M
----------------------------------------------------------------------
35
PsiBlast_CBE
50.93
31%
-90
- C3 -
2P3V
2
BSUHB_THEMA
D:
[28-216]
---------------------------------------------
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
----------
G
------
I
-------------------------------------------------
F
E
K
G
D
R
L
----------------------------------------
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
-
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
----------------
N
--
E
T
----------------
L
Y
A
E
E
G
S
G
A
F
F
N
-------
G
E
R
---------------
I
R
V
S
E
N
A
S
L
E
E
C
V
G
S
T
G
----------
S
Y
-
V
-
D
-
F
-
T
G
K
F
I
E
R
M
-
E
-
K
R
----
T
R
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
------
W
------
R
--
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
--
G
M
V
--------------------------------------------------------------------------------
12
PsiBlast_PDB
50.20
35%
-83
- C3 -
3T0J
5
?
A:
[26-238]
-----------------------------------
I
K
Q
L
M
E
Q
N
L
T
------
P
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
----------
G
H
G
-
H
D
I
D
-------------------------------------------------
T
--
S
K
G
T
V
---------------------------------------
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
-
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
----------------
D
--
V
L
----------------
Y
H
A
K
V
G
E
G
A
Y
-----------
R
G
--------
S
---
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
I
N
P
N
-----
W
--
L
T
-
K
-
P
-
I
-
L
G
E
I
F
K
E
I
-
V
-
N
D
----
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
------
P
------
R
--
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
---------
L
L
G
E
--
P
----------------------------------------------------------------