@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2703: (2016-05-13 )
MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....----------------------------------------..270.......---------------------280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.--......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510...-....520......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAATKASTATDE
P
V
K
R
TATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIP
K
R
K
T
R
A
A
A
K
S
AAAKAPSARGHATKPRAPKDAQHEAAT
D
P
E
D
A
L
D
S
V
E
E
LDAEPDLDVEPGEDLDLDAADL
N
L
D
D
LEDDVAPDADDDLDSGDDE
D
H
E
D
L
E
A
E
AAVAPGQTAD
D
D
E
E
IAEPTEKDKASGDFVWDE
D
E
S
E
A
L
R
Q
A
RKDAELTA
S
A
D
S
V
R
A
Y
L
K
QIG
K
V
A
LLN
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
----------------------------------------ERGEKLPAAQRR---------------------
D
M
M
W
I
CRDG
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
YTGR
G
M
A
F
L
D
L
I
QEGN
L
G
L
I
R
A
V
E
K
FDYTKG
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
ADQA
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
LGREP
T
P
E
E
L
A
K
EM--DI
T
P
E
K
V
L
E
I
Q
Q
Y
AREPISLDQTIGDEG
D
S
Q
L
G
D
F
IEDSE
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
EREA
G
V
V
R
L
R
FGLTDGQPR
T
L
D
E
I
G
Q
V
YG
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
LR-HP
S
R
S
Q
V
L
R
D
YLD
24
PsiBlast_CBE
93.36
51%
-96
- C6 -
4Q4Z
2
?
F:
[78-423]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLKETLD
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
38
PsiBlast_CBE
92.98
51%
-95
- C6 -
4G7O
2
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSARVRHIPGLKETLD
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
40
PsiBlast_CBE
92.97
51%
-95
- C6 -
4G7H
3
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
31
PsiBlast_CBE
92.82
51%
-94
- C6 -
4OIQ
3
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
34
PsiBlast_CBE
92.78
51%
-97
- C6 -
4OIN
3
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLKETLD
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
36
PsiBlast_CBE
92.68
51%
-94
- C6 -
4G7Z
2
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
32
PsiBlast_CBE
92.58
51%
-93
- C6 -
4OIP
3
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
30
PsiBlast_CBE
92.52
51%
-95
- C6 -
4OIR
4
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
33
PsiBlast_CBE
92.17
51%
-98
- C6 -
4OIO
2
?
F:
[98-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
LGSA
R
V
R
H
I
PGLKETLD
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
--
39
PsiBlast_CBE
91.21
51%
-92
- C6 -
4G7H
4
?
P:
[97-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEID
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
37
PsiBlast_CBE
90.79
51%
-92
- C6 -
4G7O
2
?
P:
[97-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEID
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
29
PsiBlast_CBE
90.33
51%
-94
- C6 -
5E17
3
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
---------
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
35
PsiBlast_CBE
90.13
51%
-91
- C6 -
4G7Z
2
?
P:
[97-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEID
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
28
PsiBlast_CBE
89.73
51%
-97
- C6 -
5E18
2
?
F:
[98-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLK
E
T
L
D
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
-----------
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
D
20
PsiBlast_PDB
88.88
51%
-93
- C6 -
4Q5S
1
?
F:
[78-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
I
T
GLD
P
D
L
I
R
E
V
V
R
A
K
I
L
GSA
R
V
R
H
I
PGLKETLD
P
K
T
V
E
E
I
D
Q
K
L
K
S
L
P
K
E
H
K
R
----------------------
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
-------
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
23
PsiBlast_CBE
88.54
49%
-99
- C6 -
4XLN
1
SIGA_THEAQ
L:
[1-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLDQELIREVVRAKILGT----------------------
A
R
I
Q
K
I
P
G
L
K
E
K
PDPKTVEEVDGKLKSLPKELK
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
4
PsiBlast_PDB
88.47
49%
-97
- C6 -
4XLP
-
SIGA_THEAQ
F:
[3-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLDQELIREVVRAKILGT----------------------
A
R
I
Q
K
I
P
G
L
K
E
K
PDPKTVEEVDGKLKSLPKELK
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
5
PsiBlast_PDB
87.96
49%
-92
- C6 -
4XLQ
-
SIGA_THEAQ
F:
[3-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLDQELIREVVRAKILGT----------------------
A
R
I
Q
K
I
P
G
L
K
E
K
PDPKTVEEVDGKLKSLPKELK
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
3
PsiBlast_PDB
87.81
49%
-97
- C6 -
4XLN
1
SIGA_THEAQ
F:
[1-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLDQELIREVVRAKILGT----------------------
A
R
I
Q
K
I
P
G
L
K
E
K
PDPKTVEEVDGKLKSLPKELK
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
21
PsiBlast_CBE
87.66
49%
-98
- C6 -
4XLS
1
SIGA_THEAQ
L:
[3-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLDQELIREVVRAKILGT----------------------
A
R
I
Q
K
I
P
G
L
K
E
K
PDPKTVEEVDGKLKSLPKELK
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
7
PsiBlast_PDB
87.11
49%
-100
- C6 -
4XLS
1
SIGA_THEAQ
F:
[3-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLDQELIREVVRAKILGT----------------------
A
R
I
Q
K
I
P
G
L
K
E
K
PDPKTVEEVDGKLKSLPKELK
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
46
PsiBlast_CBE
78.64
60%
-95
- C6 -
4YLP
1
RPOD_ECOLI
L:
[389-627]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
47
PsiBlast_CBE
77.80
60%
-93
- C6 -
4YLP
1
RPOD_ECOLI
F:
[389-627]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
60
PsiBlast_CBE
44.81
54%
10
- C6 -
1KU7
2
SIGA_THEAQ
A:
[2-73]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
M
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
59
PsiBlast_CBE
40.39
59%
34
- C6 -
3N97
2
SIGA_THEAQ
A:
[9-61]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
S
E
R
E
A
M
V
L
K
M
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
R
-
H
P
-----------