@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2710: (2016-05-13 )
MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALLNAAGEVELAKRIEAGLYAEHLLETRKRLGENRKRDLAAVVRDGEAARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQHLGREATDEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAMSAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIERDVMSKLRHGERADRLRSYAS
Atome Classification :
(25 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40....---------....50.......-.60..-----------------------------------------..-------------.---..----.70.......-----------------------------.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...--......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310...-.....320.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADAPTRATTSRVDSDLDAQS
P
A
A
D
L
V
R
V
Y
L
NGI
G
K
T
A
L
LNAA
G
E
---------
V
E
L
A
K
R
I
E
A
G
L
Y
A
-
E
H
L
L
E
-----------------------------------------
T
R
-------------
K
---
R
L----GE
N
R
K
R
D
L
A
A
-----------------------------
V
VRD
G
E
A
A
R
R
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
YTGRGM
P
L
L
D
L
I
QEGN
L
G
L
I
R
A
M
E
K
FDYTKGFKF
S
T
Y
A
T
W
W
I
R
Q
A
I
T
RGMADQS
R
T
I
R
L
P
V
H
L
V
E
Q
V
N
K
L
A
R
I
K
R
E
M
H
Q
HLGREA
T
D
E
E
LAAESGI--
P
I
D
--
K
I
N
D
L
L
E
HSRD
P
V
S
LDMPVGSEEEAP
L
G
D
F
I
E
D
A
E
AMSA
E
N
A
V
I
A
E
L
L
H
T
D
I
R
S
V
L
A
T
L
D
ERE
H
Q
V
I
R
L
R
FGLDDGQPR
T
L
D
Q
I
G
K
L
FGL
S
R
E
R
V
R
Q
I
E
R
D
V
M
S
K
L
R-H
G
E
R
-
A
D
R
L
R
S
YAS
21
PsiBlast_CBE
93.78
44%
-98
- C10 -
4XLS
1
SIGA_THEAQ
L:
[3-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
23
PsiBlast_CBE
93.76
44%
-99
- C10 -
4XLN
1
SIGA_THEAQ
L:
[1-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
3
PsiBlast_PDB
93.59
44%
-97
- C10 -
4XLN
1
SIGA_THEAQ
F:
[1-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
7
PsiBlast_PDB
93.35
44%
-101
- C10 -
4XLS
1
SIGA_THEAQ
F:
[3-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
5
PsiBlast_PDB
93.33
44%
-94
- C10 -
4XLQ
-
SIGA_THEAQ
F:
[3-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
6
PsiBlast_PDB
93.07
44%
-101
- C10 -
4XLR
1
SIGA_THEAQ
F:
[3-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
22
PsiBlast_CBE
93.05
44%
-100
- C10 -
4XLR
1
SIGA_THEAQ
L:
[3-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
4
PsiBlast_PDB
93.05
44%
-98
- C10 -
4XLP
-
SIGA_THEAQ
F:
[3-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
-----------------------------------------
A
T
GLDQELIREVVRA
K
---
I
L
----
G
T
A
R
I
Q
K
I
P
G
LKEKPDPKTVEEVDGKLKSLPKELKRYLH
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
80
HHSearch
91.21
50%
-84
- C10 -
2A6H
-
?
F:
[75-422]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
---------
V
E
L
A
R
K
V
E
E
G
M
E
A
-
I
K
K
L
S
EITGLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEE
I
D
-------------
Q
KLK
S
L
----
P
K
E
H
K
R
Y
L
-
H
-----------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
GW
D
A
K
--
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
-----
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
-
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
40
PsiBlast_CBE
88.76
52%
-90
- C10 -
4G7H
3
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
36
PsiBlast_CBE
88.17
52%
-92
- C10 -
4G7Z
2
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
30
PsiBlast_CBE
88.09
52%
-88
- C10 -
4OIR
4
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
33
PsiBlast_CBE
88.01
52%
-90
- C10 -
4OIO
2
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
39
PsiBlast_CBE
87.98
52%
-90
- C10 -
4G7H
4
?
P:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
38
PsiBlast_CBE
87.87
52%
-93
- C10 -
4G7O
2
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
32
PsiBlast_CBE
87.65
52%
-89
- C10 -
4OIP
3
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
31
PsiBlast_CBE
87.57
52%
-87
- C10 -
4OIQ
3
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
69
Fugue
87.29
41%
-79
- C10 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
QS
Q
L
K
L
L
V
T
R
G
K
EQGYLT
Y
A
E
V
N
D
H
LPEDIVDSD
Q
I
E
D
I
I
Q
M
I
N
D
MGIQVMGRTTDP
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
EEARLSDLITGFVDD
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
TIKA
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
FRLV
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
MNKPWSEKL
H
D
V
S
E
E
V
H
R
A
L
Q
K
-
L
Q
Q
I
E
-----------------------------------------
E
E
-------------
T
---
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
-----------------------------
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
--
P
E
D
--
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
34
PsiBlast_CBE
87.14
52%
-92
- C10 -
4OIN
3
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
37
PsiBlast_CBE
86.70
52%
-88
- C10 -
4G7O
2
?
P:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
24
PsiBlast_CBE
86.69
52%
-91
- C10 -
4Q4Z
2
?
F:
[164-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
35
PsiBlast_CBE
86.25
52%
-90
- C10 -
4G7Z
2
?
P:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
AK
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
20
PsiBlast_PDB
85.65
52%
-92
- C10 -
4Q5S
1
?
F:
[164-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
-------
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
29
PsiBlast_CBE
85.58
52%
-91
- C10 -
5E17
3
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
---------
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
28
PsiBlast_CBE
85.30
52%
-93
- C10 -
5E18
2
?
F:
[184-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
S
L
----
P
K
E
H
K
R
Y
L
H
------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
-----------
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
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E
R
I
R
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I
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N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--