@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2750: (2016-05-13 )
MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGFVNKR
Atome Classification :
(37 SA)
.........10........20........30........40-...-..----...50........60........70........80........90........100.....-----.-----.110..----.----....120.......130.......140.......150.......160.......170.......180.......190.......200.---....-.-.210---..----..-..------.-.--220...--------.---.-..------230-.-.-.....240----.........250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIDRPLEG
K
V
A
F
I
T
G
A
A
RGLG
R
A
H
A
V
R
LAADG
A
N
I
I
A
V
D
I
C
-
E
Q
I
-AS----VPYPLS
T
A
D
D
L
A
A
T
V
E
L
V
E
DAGG
G
I
V
ARQGDVR
D
R
A
S
L
S
V
A
L
Q
A
G
L
D
EFG
R
L
D
I
V
V
ANA
G
I
-----
A
-----
M
M
QAGD----D----GW
R
D
V
I
D
V
NL
T
G
V
F
H
T
V
Q
V
A
I
P
T
L
I
EQGTG
G
S
I
V
L
I
SSAA
G
L
V
GIGSSDPGS
L
G
Y
A
A
A
K
H
G
V
V
G
L
M
R
A
Y
A
N
HLAPQN
I
R
VNSVHPCGV---DTPM-I-
N
N
E
----
F
F
----
Q
Q
-
W
L
------
T
-T--ADMDAP--------H---N-LG------NAL-P-
V
-
E
L
VQP
T
------
D
I
A
N
A
V
A
W
L
ASEEA
R
Y
V
T
G
V
T
L
PVDAGFVNKR
25
PsiBlast_CBE
92.80
76%
-116
- C1 -
3SX2
2
?
D:
[10-278]
----
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
-
D
Q
I
-
A
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
L
------
A
-
K
MA
A
A
T
D
T
---------
G
---
A
-
M
G
------
N
A
M
-
P
-
V
-
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
K
-
23
PsiBlast_CBE
92.15
76%
-115
- C1 -
3SX2
2
?
F:
[10-278]
----
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
-
D
Q
I
-
A
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
L
------
A
-
K
MA
A
A
T
D
T
P
--------
G
---
A
-
M
G
------
N
A
M
-
P
-
V
-
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
K
-
1
PsiBlast_PDB
91.57
76%
-115
- C1 -
3SX2
2
?
A:
[10-278]
----
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
-
D
Q
I
-
A
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
L
------
A
-
K
M
A
A
A
T
D
----------
G
---
A
-
M
G
------
N
A
M
-
P
-
V
-
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
K
-
110
HHSearch
90.71
75%
-111
- C1 -
3SX2
2
?
A:
[9-278]
---
G
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
D
Q
I
A
--
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
L
------
A
K
M
--
A
A
A
T
D
----------G--
A
-
M
G
------
N
A
M
-
P
-
V
-
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
K
-
22
PsiBlast_CBE
90.33
76%
-115
- C1 -
3SX2
2
?
G:
[10-278]
----
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
-
D
Q
I
-
A
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
L
------
A
-
K
MA
A
A
T
-----------
G
---
A
-
M
G
------
N
A
M
-
P
-
V
-
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
K
-
24
PsiBlast_CBE
88.04
76%
-114
- C1 -
3SX2
2
?
E:
[10-278]
----
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
-
D
Q
I
-
A
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
---------------------------------
G
------
N
A
M
-
P
-
V
-
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
K
-
21
PsiBlast_CBE
86.03
76%
-118
- C1 -
3SX2
3
?
H:
[10-277]
----
P
L
T
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
L
A
A
D
G
A
D
I
I
A
V
D
L
C
-
D
Q
I
-
A
S
----
V
P
Y
P
L
A
T
P
E
E
L
A
A
T
V
K
L
V
E
D
I
G
S
R
I
V
A
R
Q
A
D
V
R
D
R
E
S
L
S
A
A
L
Q
A
G
L
D
E
L
G
R
L
D
I
V
V
A
N
A
G
I
-----
A
-----
P
M
S
A
G
D
----
D
----
G
W
H
D
V
I
D
V
N
L
T
G
V
Y
H
T
I
K
V
A
I
P
T
L
V
K
Q
G
T
G
G
S
I
V
L
I
S
S
S
A
G
L
A
G
V
G
S
A
D
P
G
S
V
G
Y
V
A
A
K
H
G
V
V
G
L
M
R
V
Y
A
N
L
L
A
G
Q
M
I
R
V
N
S
I
H
P
S
G
V
---
E
T
P
M
-
I
-
N
N
E
----
F
T
----
R
E
-
W
------------------------------------------------
E
V
L
A
P
E
------
D
V
A
N
A
V
A
W
L
V
S
D
Q
A
R
Y
I
T
G
V
T
L
P
V
D
A
G
F
L
N
--
2
PsiBlast_PDB
80.78
50%
-116
- C1 -
5EJ2
3
?
A:
[37-308]
-------
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
-
G
P
I
-
E
N
----
L
A
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
G
T
D
GR
K
-----
L
H
K
I
R
D
----
N
----
V
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
G
G
R
----
K
A
Y
P
N
T
G
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
---
S
T
T
M
-
V
M
N
D
Q
----
T
F
----
R
---
L
------
F
-
R
--
P
D
L
E
N
P
G
P
D
D
F
A
P
I
S
---
Q
-
M
M
------
H
T
L
-
P
-
V
-
P
W
V
D
A
S
------
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
L
K
-
28
PsiBlast_CBE
80.30
50%
-114
- C1 -
5EJ2
3
?
B:
[37-308]
-------
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
-
G
P
I
-
E
N
----
L
A
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
GTDGR
K
-----
L
H
K
I
R
D
----
N
----
V
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
G
G
R
----
K
A
Y
P
N
T
G
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
---
S
T
T
M
-
V
M
N
D
Q
----
T
F
----
R
---
L
------
F
-
R
--
P
D
L
E
N
P
GPDDFAPI
S
---
Q
-
M
M
------
H
T
L
-
P
-
V
-
P
W
V
D
A
S
------
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
L
K
-
26
PsiBlast_CBE
79.18
50%
-114
- C1 -
5EJ2
3
?
D:
[37-308]
-------
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
-
G
P
I
-
E
N
----
L
A
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
GTDGR
K
-----
L
H
K
I
R
D
----
N
----
V
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
G
G
R
----
K
A
Y
P
N
T
G
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
---
S
T
T
M
-
V
M
N
D
Q
----
T
F
----
R
---
L
------
F
-
R
--
P
D
L
E
N
P
GPDDFAPI
S
---
Q
-
M
M
------
H
T
L
-
P
-
V
-
P
W
V
D
A
S
------
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
L
K
-
27
PsiBlast_CBE
78.76
50%
-113
- C1 -
5EJ2
3
?
C:
[37-308]
-------
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
-
G
P
I
-
E
N
----
L
A
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
GTDGR
K
-----
L
H
K
I
R
D
----
N
----
V
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
G
G
R
----
K
A
Y
P
N
T
G
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
---
S
T
T
M
-
V
M
N
D
Q
----
T
F
----
R
---
L
------
F
-
R
--
P
D
L
E
N
P
GPDDFAPI
S
---
Q
-
M
M
------
H
T
L
-
P
-
V
-
P
W
V
D
A
S
------
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
L
K
-
32
PsiBlast_CBE
77.76
48%
-114
- C1 -
3UVE
4
?
C:
[9-286]
-----
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
-
K
P
I
-
R
A
GVVD
T
A
I
P
A
S
T
P
E
D
L
A
E
T
A
D
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
GNGGD
T
-----
L
D
K
T
S
E
----
E
----
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
G
G
L
----
K
A
Y
P
H
T
G
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
---
K
T
P
M
-
L
-
H
N
E
G---
T
F
----
K
M
-
F
R
------
P
-
D
--
L
E
N
P
G
P
--------
D
---
D
-
M
A
PICQMF
H
T
L
-
P
-
I
-
P
W
V
E
P
I
------
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
L
K
-
31
PsiBlast_CBE
77.57
48%
-112
- C1 -
3UVE
5
?
D:
[9-286]
-----
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
-
K
P
I
-
R
A
GVVD
T
A
I
P
A
S
T
P
E
D
L
A
E
T
A
D
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
GNGGD
T
-----
L
D
K
T
S
E
----
E
----
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
G
G
L
----
K
A
Y
P
H
T
G
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
---
K
T
P
M
-
L
-
H
N
E
G---
T
F
----
K
M
-
F
R
------
P
-
D
--
L
E
N
P
G
P
--------
D
---
D
-
M
A
PICQMF
H
T
L
-
P
-
I
-
P
W
V
E
P
I
------
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
L
K
-
4
PsiBlast_PDB
77.47
48%
-112
- C1 -
3UVE
4
?
A:
[9-286]
-----
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
-
K
P
I
-
R
A
GVVD
T
A
I
P
A
S
T
P
E
D
L
A
E
T
A
D
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
G
N
G
GD
T
-----
L
D
K
T
S
E
----
E
----
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
G
G
L
----
K
A
Y
P
H
T
G
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
---
K
T
P
M
-
L
-
H
N
E
G
---
T
F
----
K
M
-
F
R
------
P
-
D
--
L
E
N
P
G
P
--------
D
---
D
-
M
A
P
I
C
Q
M
F
H
T
L
-
P
-
I
-
P
W
V
E
P
I
------
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
L
K
-
33
PsiBlast_CBE
76.85
48%
-113
- C1 -
3UVE
6
?
B:
[9-286]
-----
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
-
K
P
I
-
R
A
GVVD
T
A
I
P
A
S
T
P
E
D
L
A
E
T
A
D
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
GNGGD
T
-----
L
D
K
T
S
E
----
E
----
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
G
G
L
----
K
A
Y
P
H
T
G
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
---
K
T
P
M
-
L
-
H
N
E
G---
T
F
----
K
M
-
F
R
------
P
-
D
--
L
E
N
P
G
P
--------
D
---
D
-
M
A
PICQMF
H
T
L
-
P
-
I
-
P
W
V
E
P
I
------
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
L
K
-
30
PsiBlast_CBE
74.82
46%
-109
- C1 -
3OEC
1
?
C:
[44-312]
-----
L
Q
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
T
H
A
V
R
L
A
Q
D
G
A
D
I
V
A
I
D
L
C
-
R
Q
---
N
----
L
D
Y
A
Q
G
S
P
E
E
L
K
E
T
V
R
L
V
E
E
Q
G
R
R
I
I
A
R
Q
A
D
V
R
D
L
A
S
L
Q
A
V
V
D
E
A
L
A
E
F
G
H
I
D
I
L
V
S
N
V
G
I
-----
S
N
Q
G
E
-
V
V
S
L
T
D
----
Q
----
Q
W
S
D
I
L
Q
T
N
L
I
G
A
W
H
A
C
R
A
V
L
P
S
M
I
E
R
G
Q
G
G
S
V
I
F
V
S
S
T
V
G
L
R
G
A
----
P
G
Q
S
H
Y
A
A
S
K
H
G
V
Q
G
L
M
L
S
L
A
N
E
V
G
R
H
N
I
R
V
N
S
V
N
P
G
A
V
---
N
T
E
M
A
L
-
N
E
K
----
L
L
----
K
M
-
F
L
PHLENP
T
-
R
--
E
D
A
A
E
L
--------
F
---
S
-
Q
L
------
T
L
L
-
P
-
I
-
P
W
V
E
P
E
------
D
V
S
N
A
V
A
W
L
A
S
D
E
A
R
Y
I
H
G
A
A
I
P
V
D
G
G
-----
3
PsiBlast_PDB
73.61
46%
-110
- C1 -
3OEC
1
?
A:
[44-312]
-----
L
Q
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
T
H
A
V
R
L
A
Q
D
G
A
D
I
V
A
I
D
L
C
-
R
Q
Q
-
P
N
----
L
D
Y
A
Q
G
S
P
E
E
L
K
E
T
V
R
L
V
E
E
Q
G
R
R
I
I
A
R
Q
A
D
V
R
D
L
A
S
L
Q
A
V
V
D
E
A
L
A
E
F
G
H
I
D
I
L
V
S
N
V
G
I
-----
S
N
Q
G
E
-
V
V
S
L
T
D
----
Q
----
Q
W
S
D
I
L
Q
T
N
L
I
G
A
W
H
A
C
R
A
V
L
P
S
M
I
E
R
G
Q
G
G
S
V
I
F
V
S
S
T
V
G
L
R
G
A
----
P
G
Q
S
H
Y
A
A
S
K
H
G
V
Q
G
L
M
L
S
L
A
N
E
V
G
R
H
N
I
R
V
N
S
V
N
P
G
A
V
---
N
T
E
M
A
L
-
N
E
K
----
L
L
----
K
M
-
F
L
PHLENP
T
-
R
--
E
D
A
A
E
L
--------
F
---
S
-
Q
L
------
T
L
L
-
P
-
I
-
P
W
V
E
P
E
------
D
V
S
N
A
V
A
W
L
A
S
D
E
A
R
Y
I
H
G
A
A
I
P
V
D
G
G
-----
29
PsiBlast_CBE
72.96
46%
-111
- C1 -
3OEC
1
?
D:
[44-312]
-----
L
Q
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
T
H
A
V
R
L
A
Q
D
G
A
D
I
V
A
I
D
L
C
-
R
Q
Q
--
N
----
L
D
Y
A
Q
G
S
P
E
E
L
K
E
T
V
R
L
V
E
E
Q
G
R
R
I
I
A
R
Q
A
D
V
R
D
L
A
S
L
Q
A
V
V
D
E
A
L
A
E
F
G
H
I
D
I
L
V
S
N
V
G
I
-----
S
N
Q
G
E
-
V
V
S
L
T
D
----
Q
----
Q
W
S
D
I
L
Q
T
N
L
I
G
A
W
H
A
C
R
A
V
L
P
S
M
I
E
R
G
Q
G
G
S
V
I
F
V
S
S
T
V
G
L
R
G
A
----
P
G
Q
S
H
Y
A
A
S
K
H
G
V
Q
G
L
M
L
S
L
A
N
E
V
G
R
H
N
I
R
V
N
S
V
N
P
G
A
V
---
N
T
E
M
A
L
-
N
E
K
----
L
L
----
K
M
-
F
L
PHLENP
T
-
R
--
E
D
A
A
E
L
--------
F
---
S
-
Q
L
------
T
L
L
-
P
-
I
-
P
W
V
E
P
E
------
D
V
S
N
A
V
A
W
L
A
S
D
E
A
R
Y
I
H
G
A
A
I
P
V
D
G
G
-----
6
PsiBlast_PDB
71.64
50%
-106
- C1 -
3TSC
1
?
A:
[9-273]
-----
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
-
G
K
L
-
P
S
C---
V
P
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
-----
A
-----
A
P
Q
A
W
D
----
D
IT
P
E
D
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
A
G
M
----
K
M
Q
P
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
---
N
T
P
M
-
G
-
S
G
D
----
M
V
T
A
V
G
Q
A
-
M
E
------
T
-
N
--
P
Q
L
S
----------
H
---
V
-
L
T
------
P
F
L
-
P
-
D
-
W
V
A
E
P
E
------
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
-----
38
PsiBlast_CBE
71.50
50%
-108
- C1 -
3TSC
3
?
C:
[9-273]
-----
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
-
G
K
L
-
P
S
C---
V
P
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
-----
A
-----
A
P
Q
A
W
D
----
D
ITPE
D
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
A
G
M
----
K
M
Q
P
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
---
N
T
P
M
-
G
-
S
G
D
----
M
V
TAVG
Q
A
-
M
E
------
T
-
N
--
P
Q
L
S
----------
H
---
V
-
L
T
------
P
F
L
-
P
-
D
-
W
V
A
E
P
E
------
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
-----
107
HHSearch
71.45
48%
-107
- C1 -
3TSC
1
?
A:
[7-276]
---
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
P
-
S
C
----
V
P
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
-----
A
A
P
Q
A
-
W
D
D
I
T
P
----
E
----
D
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
A
G
M
K
M
Q
P
----
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
---
N
T
P
M
-
G
-
S
G
D
----
M
V
----
T
A
V
G
Q
A
M
----
E
-
T
--
N
P
Q
L
S
H
--------------
V
L
------
T
P
F
L
P
-
D
-
W
V
A
E
P
E
------
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
--
37
PsiBlast_CBE
71.44
50%
-106
- C1 -
3TSC
1
?
D:
[9-273]
-----
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
-
G
K
L
-
P
S
C---
V
P
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
-----
A
-----
A
P
Q
A
W
D
----
D
ITPE
D
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
A
G
M
----
K
M
Q
P
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
---
N
T
P
M
-
G
-
S
G
D
----
M
V
TAVG
Q
A
-
M
E
------
T
-
N
--
P
Q
L
S
----------
H
---
V
-
L
T
------
P
F
L
-
P
-
D
-
W
V
A
E
P
E
------
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
-----
5
PsiBlast_PDB
71.44
48%
-108
- C1 -
3T7C
1
?
A:
[26-299]
-----
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
-
K
Q
L
-
D
G
----
V
K
L
P
M
S
T
P
D
D
L
A
E
T
V
R
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
-----
A
S
EGTR
L
N
R
M
D
P
----
K
----
T
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
G
G
L
R
--
G
A
E
N
I
G
N
--
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
---
A
T
P
M
-
L
-
L
N
E
P
T
Y
R
M
F
----
R
P
-
D
L
ENP---
T
-
V
--
E
D
F
Q
V
A
--------
S
---
R
-
Q
M
------
H
V
L
-
P
-
I
-
P
Y
V
E
P
A
------
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
L
K
-
39
PsiBlast_CBE
71.26
50%
-109
- C1 -
3TSC
1
?
B:
[9-273]
-----
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
-
G
K
L
-
P
S
C---
V
P
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
-----
A
-----
A
P
Q
A
W
D
----
D
ITPE
D
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
A
G
M
----
K
M
Q
P
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
---
N
T
P
M
-
G
-
S
G
D
----
M
V
TAVG
Q
A
-
M
E
------
T
-
N
--
P
Q
L
S
----------
H
---
V
-
L
T
------
P
F
L
-
P
-
D
-
W
V
A
E
P
E
------
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
-----
8
PsiBlast_PDB
70.98
41%
-108
- C1 -
4RGB
1
?
A:
[23-294]
-----
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
-
E
D
I
-
D
I
----
V
P
Y
K
L
G
T
Y
E
E
L
E
E
T
A
R
L
V
E
K
T
G
Q
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
-----
V
-----
L
T
N
P
D
E
RD
A
S
E
----
A
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
G
Q
G
G
N
L
I
A
T
S
S
M
I
A
L
L
D
L
T
D
G
R
G
G
T
D
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
---
S
T
P
M
-
I
-
T
E
-----------
N
P
-
A
L
------
F
-
K
--
V
I
E
E
N
P
--------
H
LVN
A
-
M
S
------
T
A
L
-
P
D
F
-
P
M
I
E
P
R
------
D
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
M
D
V
K
R
36
PsiBlast_CBE
70.81
48%
-106
- C1 -
3T7C
1
?
B:
[26-299]
-----
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
-
K
Q
L
-
D
G
----
V
K
L
P
M
S
T
P
D
D
L
A
E
T
V
R
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
-----
A
S
EGTR
L
N
R
M
D
P
----
K
----
T
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
G
G
L
R
--
G
A
E
N
I
G
N
--
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
---
A
T
P
M
-
L
-
L
N
E
P
T
Y
R
M
F
----
R
P
-
D
L
ENP---
T
-
V
--
E
D
F
Q
V
A
--------
S
---
R
-
Q
M
------
H
V
L
-
P
-
I
-
P
Y
V
E
P
A
------
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
L
K
-
35
PsiBlast_CBE
70.58
48%
-106
- C1 -
3T7C
1
?
C:
[26-299]
-----
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
-
K
Q
L
-
D
G
----
V
K
L
P
M
S
T
P
D
D
L
A
E
T
V
R
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
-----
A
SEGTR
L
N
R
M
D
P
----
K
----
T
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
G
G
L
R
--
G
A
E
N
I
G
N
--
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
---
A
T
P
M
-
L
-
L
N
E
PTYR
M
F
----
R
P
-
D
L
ENP---
T
-
V
--
E
D
F
Q
V
A
--------
S
---
R
-
Q
M
------
H
V
L
-
P
-
I
-
P
Y
V
E
P
A
------
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
L
K
-
34
PsiBlast_CBE
70.28
48%
-107
- C1 -
3T7C
1
?
D:
[26-299]
-----
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
-
K
Q
L
-
D
G
----
V
K
L
P
M
S
T
P
D
D
L
A
E
T
V
R
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
-----
A
SEGTR
L
N
R
M
D
P
----
K
----
T
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
G
G
L
R
--
G
A
E
N
I
G
N
--
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
---
A
T
P
M
-
L
-
L
N
E
PTYR
M
F
----
R
----P-----
T
-
V
--
E
D
F
Q
V
A
--------
S
---
R
-
Q
M
------
H
V
L
-
P
-
I
-
P
Y
V
E
P
A
------
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
L
K
-
43
PsiBlast_CBE
69.92
41%
-108
- C1 -
4RGB
1
?
B:
[23-294]
-----
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
-
E
D
I
-
D
I
----
V
P
Y
K
L
G
T
Y
E
E
L
E
E
T
A
R
L
V
E
K
T
G
Q
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
-----
V
-----
L
T
N
P
D
E
RDAS
E
----
A
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
G
Q
G
G
N
L
I
A
T
S
S
M
I
A
L
L
D
L
T
D
G
R
G
G
T
D
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
---
S
T
P
M
-
I
-
T
E
-----------
N
P
-
A
L
------
F
-
K
--
V
I
E
E
N
P
--------
H
LVN
A
-
M
S
------
T
A
L
-
P
D
F
-
P
M
I
E
P
R
------
D
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
M
D
V
K
R
106
HHSearch
68.61
40%
-102
- C1 -
4RGB
1
?
A:
[21-294]
---
G
S
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
E
D
I
D
--
I
----
V
P
Y
K
L
G
T
Y
E
E
L
E
E
T
A
R
L
V
E
K
T
G
Q
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
-----
V
LTNP-
D
E
R
D
A
S
----
E
----
A
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
G
Q
G
G
N
L
I
A
T
S
S
M
I
A
L
L
D
L
T
D
G
R
G
G
T
D
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
---
S
T
P
M
-
I
-
T
E
N
----
P
A
----
L
F
-
K
V
I
-----
E
-
E
--
N
P
H
L
V
N
--------
A
---
M
S
T
A
------
L
P
D
---
F
-
P
M
I
E
P
R
------
D
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
M
D
V
K
R
40
PsiBlast_CBE
68.22
45%
-107
- C1 -
3PGX
1
Y4146_MYCPA
D:
[13-276]
-----
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
-
A
P
V
S
A
S
----
V
T
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
LSWG-
R
-----
V
W
E
L
T
D
----
E
----
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
G
L
----
K
A
T
P
G
N
G
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
---
E
T
P
M
-
I
-
E
P
E
----
A
M
----
M
E
----------------
I
F
A
R
--------
H
P--
S
-
F
V
------
H
S
F
-
P
-
P
-
M
P
V
Q
P
N
GFMTAD
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
-----
7
PsiBlast_PDB
67.61
45%
-106
- C1 -
3PGX
1
Y4146_MYCPA
A:
[13-276]
-----
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
-
A
P
V
S
A
S
----
V
T
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
W
G
-
R
-----
V
W
E
L
T
D
----
E
----
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
G
L
----
K
A
T
P
G
N
G
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
---
E
T
P
M
-
I
-
E
P
E
----
A
M
----
M
E
----------------
I
F
A
R
--------
H
P--
S
-
F
V
------
H
S
F
-
P
-
P
-
M
P
V
Q
P
N
G
F
M
T
A
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
-----
41
PsiBlast_CBE
67.06
45%
-107
- C1 -
3PGX
1
Y4146_MYCPA
C:
[13-276]
-----
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
-
A
P
V
S
A
S
----
V
T
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
LSWG-
R
-----
V
W
E
L
T
D
----
E
----
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
G
L
----
K
A
T
P
G
N
G
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
---
E
T
P
M
-
I
-
E
P
E
----
A
M
----
M
E
----------------
I
F
A
R
--------
H
P--
S
-
F
V
------
H
S
F
-
P
-
P
-
M
P
V
Q
P
N
GFMTAD
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
-----
42
PsiBlast_CBE
67.00
45%
-105
- C1 -
3PGX
1
Y4146_MYCPA
B:
[13-276]
-----
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
-
A
P
V
S
A
S
----
V
T
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
LSWG-
R
-----
V
W
E
L
T
D
----
E
----
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
G
L
----
K
A
T
P
G
N
G
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
---
E
T
P
M
-
I
-
E
P
E
----
A
M
----
M
E
----------------
I
F
A
R
--------
H
P--
S
-
F
V
------
H
S
F
-
P
-
P
-
M
P
V
Q
P
N
GFMTAD
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
-----
52
PsiBlast_CBE
62.46
36%
-104
- C1 -
4URE
6
?
B:
[3-248]
-----
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
S
D
I
S
-
D
E
W
-
G
R
----------------
E
T
L
A
L
I
E
G
K
G
G
K
A
V
F
Q
H
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
-----
S
GEFTP
T
A
E
T
T
D
----
A
----
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G
-
G
G
A
I
V
N
I
S
S
I
A
G
Q
I
G
I
E
G
I
T
P
----
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
V
G
P
A
F
I
---
N
T
T
L
-
V
-
Q
N
V
----
P
L
----
E
T
-
R
R
------
Q
-
L
--
E
Q
M
H
A
L
--------
R
---
R
-
L
G
-----------------
E
T
E
------
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
R
-
95
PsiBlast_CBE
61.46
34%
-114
- C1 -
4I08
6
FABG_VIBCH
A:
[10-248]
-----
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
-
E
S
G
-
A
Q
----------------
A
I
S
D
Y
L
G
D
N
G
K
G
M
A
L
---
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
-----
T
RDNL-
L
M
R
M
K
E
----
E
----
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
----
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
---
E
T
D
M
---
N
D
E
----------
Q
R
-
T
A
------
T
-
L
--
A
Q
V
P
A
G
--------
R
----------------------
L
G
D
P
R
------
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
----
13
PsiBlast_PDB
57.23
35%
-105
- C1 -
3OSU
15
FABG_STAAM
A:
[5-243]
--------
K
S
A
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
Q
L
A
E
E
G
Y
N
V
------------
A
----
V
N
Y
A
G
S
K
-
E
K
A
E
A
V
V
E
E
I
K
A
K
G
V
D
S
F
A
I
Q
A
N
V
A
D
A
D
E
V
K
A
M
I
K
E
V
V
S
Q
F
G
S
L
D
V
L
V
N
N
A
G
I
-----
T
RDNL-
L
M
R
M
K
E
----
Q
----
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
T
P
Q
M
L
R
Q
R
S
G
-
A
I
I
N
L
S
S
V
V
G
A
V
G
----
N
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
R
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
VSD
M
T
D
A
-
L
-
S
D
E
----
L
K
----
E
Q
-
M
L
------
T
-
Q
--------------------------------
I
-
P
-
L
A
R
F
G
Q
D
T
------
D
I
A
N
T
V
A
F
L
A
S
D
K
A
K
Y
I
T
G
Q
T
I
H
V
N
G
G
-----