@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2781c: (2016-05-13 )
MVLGFWDIAVPIVGAPMAGGPSTPALAAAVSNAGGLGFVAGGYLSADRLADDIAAARAATTGPIGANLFVPQPSVADWAQLEYYADELEEVAEYYHTEVGQPVYGDDDDWVRKLEVVADVRPEVVSFTFGAPPPDVVQRLSALGLLVSITVTSVYEAGVAIAAGADSLVVQGPAAGGHRGTFAPDMEPGTESLHQLLDRIGSAHDVPLVAAGGLGTAEDVAAVLRRGAIAAQVGTALLLADEAGTNAAHRAALKNPEFDATLVTRAFSGRYARGLANNFTRLLDHVAPLGYPEVHQMTKPIRAAAVQADDPHGTNLWAGSAHRKTRPGPAADIIASLTPDVCSA
Atome Classification :
(20 SA)
----.........10........20.-------.......30........-40..-...--...50........60-.........70........80........90........100..---....---.110..-.------..-----..120-.-......-..130.-.--.------......140----------.......--150.----......--------------------------.160-.......170.......180.---.---.....190.......200.-----------.--.....210.......220.......230.......240.......250-.......260......-------------.270.......280.....---.-----.--------290----.---.----..----.-..-----------------.300------------........310---.......320..-...-----------.-.330.......340..----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----
M
V
L
G
F
W
D
IA
V
P
IVGAPMAGGPS-------T
P
A
L
A
A
A
VSNAGGL
G
F
V-AGGY-L
S
A
--
D
R
L
A
D
D
I
A
A
ARAAT--TGPIGA
N
L
FVPQPSV
A
D
W
A
Q
L
E
Y
Y
A
D
E
L
E
E
V
A
E
Y
Y
H
TEVGQPVY---GD
D
D
---
D
W
V
R
K
L
-
E
------
V
V
-----ADV---R-P
E
V
V
S
F
-TFG--A-P--
P
------
P
D
V
V
Q
R
L
S
A----------L
G
L
L
V
S
I
--
T
-
V
T
----
S
V
Y
EAG--------------------------
V
A
IA-AGA
D
S
L
V
V
QGPAAGGHRGTFA---P---DMEP
G
T
E
S
L
H
Q
L
L
D
R
IGSA-----------H--DV
P
L
V
AAGGLG
T
A
E
D
V
A
A
V
L
RRG
A
I
A
A
QV
G
T
A
L
L
L
ADEAGT
N
A
A
H
R
AA-LKNPEF
D
A
T
L
V
T
R
AFS-------------
G
R
Y
A
R
G
L
A
N
N
F
T
R
L
L
D
H
VA---P-----L--------G-
Y
----
P
---
E
----
V
H
----
Q
-
M
T-----------------K
P
-
I
------------
R
A
AAVQADDPH---GTNLWAGSAHRK-TRP-----------G-
P
A
A
D
I
I
A
S
LT
P
D
VCSA----------
53
HHSearch
87.67
36%
-76
- C1 -
4QIT
2
?
A:
[11-356]
-----
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
P
P
V
R
L
K
NIY
L
S
F
L
---
E
D
P
T
L
L
-
P
------
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
---
P
---
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
-----------
G
--
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
---
V
-----
P
--------
P
-
L
----
P
DY
P
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
R
------------
23
PsiBlast_CBE
84.79
39%
-74
- C1 -
4QIT
2
?
B:
[17-355]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
2
PsiBlast_PDB
84.72
39%
-74
- C1 -
4Q4K
1
?
A:
[11-349]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
1
PsiBlast_PDB
84.17
39%
-75
- C1 -
4QIS
1
?
A:
[16-354]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
24
PsiBlast_CBE
83.94
39%
-75
- C1 -
4QIU
2
?
B:
[16-354]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
DPTLLP
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
4
PsiBlast_PDB
83.94
39%
-73
- C1 -
4QIU
2
?
A:
[16-354]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
21
PsiBlast_CBE
83.92
39%
-73
- C1 -
4QIS
1
?
B:
[16-354]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
22
PsiBlast_CBE
83.90
39%
-73
- C1 -
4Q4K
1
?
B:
[11-349]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
3
PsiBlast_PDB
83.83
39%
-75
- C1 -
4QIT
2
?
A:
[17-355]
-----------
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
-------
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
--
E
K
G
R
A
L
I
R
E
V
R
G
L
T
--
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
G
A
E
---
P
P
V
---
R
L
K
N
---
I
Y
L
S
F
L
-
E
D
P
T
L
L
P
M
L
-----
L
E
E
---
R
-
P
A
A
V
S
F
-
H
F
G
--
A
-
P
--
P
------
R
D
Q
V
R
A
L
Q
A
----------
V
G
I
R
V
L
V
--
C
-
A
T
----
T
P
E
E
A
A
--------------------------
L
V
E
A
-
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
---
P
ERG
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
----------------
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
-
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
-------------
G
R
S
A
R
G
L
P
N
R
M
--
F
F
D
A
A
A
---
P
GVPPL
P
--------
D
-
Y
----
P
---
F
----
V
Y
----
D
-
A
T
-----------------
K
A
-
L
------------
Q
T
A
A
L
A
R
G
N
H
D
---
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
-----------
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
-------------
54
HHSearch
75.37
29%
-85
* C1 *
4IQL
7
?
A:
[24-325]
-----
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
-
C
S
-------
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
-
G
A
G
S
-
M
H
P
--
D
N
L
E
H
H
I
R
S
C
K
A
A
T
--
D
K
P
F
G
V
N
V
P
L
L
Y
P
E
-----------------------------------------
M
D
K
I
M
-
E
------
I
I
-----
M
R
E
---
H
-
V
P
V
V
V
T
-
S
A
G
--
S
-
P
---------
K
V
W
T
A
K
L
K
A
----------
A
G
S
K
V
I
H
--
V
-
V
S
----
S
A
T
F
A
R
--------------------------
K
S
E
A
-
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
E
-------------
E
T
T
T
L
C
L
I
P
E
V
V
D
A
-----------
V
--
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
-
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
--------------
V
S
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
---
Q
RG---
A
--------
S
-
V
----
E
---
E
----
L
R
----
E
-
L
L
-----------------
G
R
G
R
------------
A
K
Q
G
I
F
E
G
D
L
H
---
E
G
E
L
E
I
G
Q
A
V
S
Q
-
I
S
H
-----------
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
----------
57
HHSearch
73.60
28%
-88
- C1 -
3BO9
13
?
A:
[19-316]
-----
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
-
A
G
-------
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
-
G
S
G
A
-
M
K
P
--
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
--
D
K
P
F
G
V
N
I
I
L
V
S
P
W
-----------------------------------------
A
D
D
L
V
-
K
------
V
C
-----
I
E
E
---
K
-
V
P
V
V
T
F
-
G
A
G
--
N
-
P
---------
T
K
Y
I
R
E
L
K
E
----------
N
G
T
K
V
I
P
--
V
-
V
A
----
S
D
S
L
A
R
--------------------------
M
V
E
R
-
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
V
---------------
T
T
F
V
L
V
N
K
V
S
R
S
-----------
V
--
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
-
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
-------------
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
---
F
-----
E
--------
N
P
M
----
Q
---
A
----
E
E
----
M
-
L
V
-----------------
G
S
-
L
------------
R
R
A
V
-
V
E
G
D
L
E
---
R
G
S
F
M
V
G
Q
S
A
G
L
-
I
D
E
-----------
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
----------
55
HHSearch
72.31
26%
-83
- C1 -
2Z6I
5
?
A:
[5-308]
-----
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
-
V
A
-------
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
P
K
--
E
V
V
K
A
N
I
D
K
I
K
S
L
T
--
D
K
P
F
G
V
N
I
M
L
L
S
P
F
-----------------------------------------
V
E
D
I
V
-
D
------
L
V
-----
I
E
E
---
G
-
V
K
V
V
T
T
-
G
A
G
--
N
-
P
---------
S
K
Y
M
E
R
F
H
E
----------
A
G
I
I
V
I
P
--
V
-
V
P
----
S
V
A
L
A
K
--------------------------
R
M
E
K
-
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
L
---------------
T
T
M
T
L
V
R
Q
V
A
T
A
-----------
I
--
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
-
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
-------------
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
---
K
-----
D
--------
A
-
F
K
Q------
D
L
E
I
F
E
Q
----
M
-
G
A
-----------------
G
A
-
L
------------
A
K
A
V
-
V
H
G
D
V
D
---
G
G
S
V
M
A
G
Q
I
A
G
L
-
V
S
K
-----------
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
-----------
56
HHSearch
69.79
23%
-85
- C1 -
2GJL
1
2NPD_PSEAE
A:
[8-316]
-----
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
-
V
G
-------
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
-
S
A
L
T
Q
P
S
P
--
E
A
L
A
A
E
I
A
R
C
R
E
L
T
--
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
K
P
----------------------------------
V
---
P
Y
A
E
Y
R
-
A
------
A
I
-----
I
E
A
---
G
-
I
R
V
V
E
T
-
A
G
N
--
D
-
P
---------
G
E
H
I
A
E
F
R
R
----------
H
G
V
K
V
I
H
--
K
-
C
T
----
A
V
R
H
A
L
--------------------------
K
A
E
R
-
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
D
-------------
D
I
P
G
L
V
L
L
P
A
A
A
N
R
-----------
L
--
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
-
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
-------------
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
---
A
R
GG--
A
--------
G
-
Y
----
A
---
D
----
I
A
----
A
-
L
V
S
G
---------------
Q
R
-
G
------------
R
Q
V
-
Y
Q
Q
G
D
T
D
---
L
G
I
W
S
A
G
M
V
Q
G
L
-
I
D
D
-----------
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
----------
77
Fugue
69.16
22%
-83
- C1 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
VFRT
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
-
V
G
-------
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
-
P
S
P
--
E
A
L
A
A
E
I
A
R
C
R
E
L
T
--
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
----------------------------------
K
P
V
---
P
Y
A
E
Y
R
-
A
------
A
I
-----
I
E
A
---
G
-
I
R
V
V
E
T
-
A
G
N
----
D
--
P
------
G
E
H
I
A
E
F
R
R
----------
H
G
V
K
V
I
H
--
K
-
C
T
----
A
V
R
H
A
L
--------------------------
K
A
E
R
-
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
D
D
---
I
----------
P
G
L
V
L
L
P
A
A
A
N
R
-----------
L
--
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
-
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
-------------
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
---
A
-----
R
--------
G
-
G
----
A
---
G
----
Y
A
DIAA
L
-
V
S
-----------------
G
Q
-
R
------------
G
R
Q
V
Y
Q
Q
G
D
T
D
---
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
-----------
P
-
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
RQR
L
E
G
M
L
A
5
PsiBlast_PDB
64.75
26%
-80
- C1 -
3BO9
13
?
A:
[39-312]
---------------------------------
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
-
G
S
G
A
-
M
K
P
--
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
--
D
K
P
F
G
V
N
I
I
L
V
S
P
----
W
A
-------------------------------
D
---
D
L
V
K
-----------------
V
C
I
---
E
-
E
K
V
P
V
V
-
T
F
G
--
A
G
N
--
P
------
T
K
Y
I
R
E
L
K
E
----------
N
G
T
K
V
I
P
--
V
-
V
A
----
S
D
S
L
A
R
--------------------------
M
V
E
R
-
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
V
---------------
T
T
F
V
L
V
N
K
V
S
R
S
-----------
V
--
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
-
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
-------------
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
---
F
-----
E
--------
N
-
P
----
M
---
Q
----
A
E
----
E
M
L
V
-----------------
G
S
-
L
------------
R
R
A
V
V
E
G
D
L
E
R
---
G
S
F
M
V
G
Q
S
A
G
L
I
-
D
E
I
-----------
K
-
P
V
K
Q
I
I
E
D
I
L
K
E
--------------
6
PsiBlast_PDB
58.74
27%
-89
- C1 -
2Z6J
5
?
A:
[28-248]
------------------------------------
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
P
K
--
E
V
V
K
A
N
I
D
K
I
K
S
L
T
--
D
K
P
F
G
V
N
I
M
L
L
S
P
F
V
E
D
I
V
D
L
-----
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
-----------------------------------------------------------
P
------
S
K
Y
M
E
R
F
H
E
----------
A
G
I
I
V
I
P
--
V
-
V
P
----
S
V
A
L
A
K
--------------------------
R
M
E
K
-
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
L
---------------
T
T
M
T
L
V
R
Q
V
A
T
A
-----------
I
--
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
-----------------
H
A
V
R
A
I
K
N
Q
L
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
56.88
23%
-77
- C1 -
4CW5
1
?
A:
[19-442]
-----
F
K
K
D
Y
N
I
Q
Y
A
Y
M
T
G
S
M
Y
R
G
I
A
-------
S
E
Q
M
V
I
K
A
A
K
A
G
M
L
G
F
F
-
G
T
G
G
-
L
S
I
--
E
R
I
G
Q
A
I
G
T
I
R
S
A
L
RQ
G
E
T
F
G
M
N
L
L
H
H
M
M
S
P
-----------------------------------
D
---
K
E
V
R
M
I
-
D
------
L
Y
-----
L
K
N
---
G
-
I
H
L
I
E
A
-
S
A
F
MG
I
-
T
--
P
------
A
L
V
I
Y
R
A
K
G
L
S
R
N
HDG
S
V
S
V
Q
N
K
I
I
A
--
K
-
V
S
----
R
P
E
V
A
E
A
F
L
NPAP
A
H
V
L
E
R
L
V
S
D
NRLT
A
G
E
A
A
L
A
K
E
I
P
M
A
D
D
I
C
V
E
-
A
---------------------------
T
L
M
P
A
M
I
R
L
R
D
R
M
M
E
K
H
GYA
K
--
K
V
R
I
G
A
A
G
G
I
G
T
P
E
A
A
A
A
A
F
L
L
G
A
E
F
I
G
T
G
S
I
N
Q
C
T
V
E
A
G
T
S
D
S
V
K
D
L
-
L
Q
E
A
N
V
Q
D
T
S
Y
A
P
A
G
D
MFEAG
A
R
V
Q
V
LKK
G
L
F
F
P
A
R
A
N
K
L
F
D
L
Y
R
Q
Y
N
SLD
E
ID---
E
K
T
K
T
L
I
E
E
K
Y
F
QRS
F
E
---
E
----
V
Y
----
E
-
Q
L
K
R
D
KS
P
E
Q
I
A
K
A
E
Q
N
P
K
H
K
-
M
A
M
V
F
K
W
Y
F
S
H
T
T
R
L
A
--
L
E
G
K
S
E
SKI
D
Y
Q
I
H
C
G
P
A
L
G
A
-
F
N
Q
W
V
KGTPLENWR
N
R
H
V
D
L
I
G
K
Q
L
M
E
E
T
A
------------
76
HHSearch
56.69
21%
-117
- C1 -
1P0K
1
IDI2_BACSU
A:
[49-288]
-----
I
G
E
L
S
-
S
S
S
P
I
F
I
N
A
M
T
G
-
G
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
-
G
S
Q
M
-
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P-
N
G
L
I
F
A
N
L
G
S
E
A
T
-------------------------------------------
A
A
Q
A
K
E
------
A
V
-----
E
M
I
---
G
-
A
N
A
L
Q
I
-
H
L
N
--
V
-
I
--
Q
EIFSG
A
L
K
R
I
E
Q
I
C
S
R
---------
V
S
V
P
V
I
V
--
K
-
E
V
G
F
G
M
S
K
A
S
A
G
--------------------------
K
L
Y
E
-
A
G
A
A
A
V
D
I
G
G
-----------R
Q
I
S
---
F
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
-----------
F
P-
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
55.95
22%
-88
- C1 -
2NLI
3
?
A:
[74-325]
-----
I
L
G
H
K
-
I
K
A
P
F
I
M
A
P
I
A
A
-
H
G
LAHTTK-
E
A
G
T
A
R
A
V
S
E
F
G
T
I
M
S
I
-
S
A
Y
S
-
G
A
T
----
F
-
E
E
I
S
E
G
L
N
----
G
G
P
R
W
F
Q
I
Y
M
A
K
D
D
----
Q
Q
N
R
D
I
L
D
E
A
----
K
S
D
G
A
T
A
I
I
L
-
T
---
A
D
S
T
NRD--------------
Y
P
FGM
P
I
V
Q
R
YLR
G
T
A
E
G
M
--Y
G
A
S
--
K
-
Q
KI
S
------
P
R
D
I
E
E
I
A
G
H
---------
S
G
L
P
V
F
V
--
K
G
I
Q
----
H
P
E
D
A
D
--------------------------
M
A
I
K
-
R
G
A
S
G
I
W
V
S
N
H
G
--
A
R
Q
L
Y
E
-------------
A
P
G
S
F
D
T
L
P
A
I
A
E
R
-----------
V
NK
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
54.74
18%
-95
- C1 -
3R2G
-
?
A:
[35-240]
-----
R
L
G
K
L
T
L
N
L
P
V
I
S
A
N
M
D
T
-
I
T
-------
E
S
N
M
A
N
F
M
H
S
K
G
A
M
G
A
L
-
H
R
F
M
--
T
I
--
E
E
N
I
Q
E
F
---
K
K
C
---
K
G
P
V
F
V
S
V
G
C
T
E
------------------------------------------
N
E
L
Q
R
A
-
E
------
A
L
-----
R
D
A
---
G
-
A
D
F
F
C
V
-
D
V
A
--
H
-
A
--
H
A
K
Y
V
--
G
K
T
L
K
S
L
R
Q
L
---------
L
G
S
R
C
I
M
A
G
N
-
V
A
----
T
Y
A
G
A
D
--------------------------
Y
L
A
S
-
C
G
A
D
I
I
K
A
-
G
I
G
G
G
S
V
C
S
T
-
R
---
I
---
K
-
T
G
F
G
V
P
M
L
T
C
I
Q
D
C
S
R
------------
A
--
D
R
S
I
V
A
D
G
G
I
K
T
S
G
D
I
V
K
A
L
A
F
G
A
D
F
V
M
I
G
G
M
L
A
G
S
A
P
T
P
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------