@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2789c: (2016-05-13 )
MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQMLDGERAKREKRDSSGSFGLADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHVTRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDNVRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQNMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA
Atome Classification :
(24 SA)
--------------------.........10..---......20........-30.....-.--..40........50........60........70........80........90...--.....100.......110.......120.......130.......140.......150...-....160.......170.......180.......190.......200.......210.......220.......230.......240....--...250.......260.......270.......280.......290.......300.......310--..----.......320.....-------------..330.-----------....--..340..-.....350.......360.......370.......380.......390.......400.......410-----------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------MFEWSD
T
D
L
M
V
R
D
---
A
V
R
Q
F
I
D
KEIRPHQDA-LETGELS-P--
Y
P
I
A
R
K
L
F
S
QFG
L
D
V
L
L
A
E
S
V
N
Q
M
L
D
G
E
R
A
K
R
EKRDSSGSFGL
A
D
Q
A
S
M
V
A
V
L
V
S
E
L
--
A
G
V
S
I
G
L
L
S
T
V
A
V
S
LG
L
G
A
A
T
I
M
SRGTL
A
Q
Q
ERWV
P
T
L
V
T
L
E
K
I
A
A
W
A
ITEPDSGSDAFGG-M
K
T
H
V
TRDGE
D
Y
I
LNG
H
K
T
F
ITNGP
Y
A
D
V
L
V
V
Y
A
KLADGEP
A
S
DWRNR
P
V
L
V
F
V
LDAGMPGLTQGK
P
F
K
KMGMMSSPTG
E
L
F
F
DNVRLTPD--
R
L
L
CAEGDGRD
S
A
R
A
N
F
A
V
E
R
L
G
V
A
L
M
S
L
G
I
I
N
E
C
H
R
L
C
V
D
Y
A
K
T
R
T
L
WGRNIG
Q
F
Q
L
I
Q
L
K
L
A
----
K
M
----
E
V
A
R
I
N
V
Q
N
M
V
F
Q
A
I
-------------
E
R
L
KAG-----------
K
Q
L
T
--
L
AE
A
S
A
I
-
K
L
YSSEA
A
T
D
V
A
M
E
A
V
Q
L
FGGNG
Y
M
A
E
Y
R
V
E
Q
L
A
R
D
A
K
S
L
M
I
Y
AGSNE
V
Q
V
T
H
I
A
K
G
L
LGEPASRA-------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
93.85
34%
-90
- C2 -
2PG0
2
?
A:
[8-383]
---------------------
R
Y
L
R
E
E
H
H
M
F
R
A
---
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
-
W
E
K
R
G
I
I
-
P
--
R
----
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
-------------
Y
G
G
L
N
--
A
D
F
A
Y
S
V
V
I
N
E
E
L
--
E
K
V
G
S
S
L
V
-
G
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
-
A
N
-
I
S
T
T
A
V
K
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
Q
A
K
P
---
P
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
--
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
----
E
M
----
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
-------------
E
E
H
M
A
G
-----------
K
-
Q
I
--
V
T
E
V
S
M
A
-
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
74
Fugue
93.40
30%
-90
- C2 -
2Z1Q
2
?
B:
[5-577]
KKLWQKGGGWLLEVPE
R
V
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
---
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
-
M
E
H
G
E
------
L
E
L
N
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
----------------
D
L
P
K
V
I
S
T
V
V
A
E
E
--
L
S
G
S
G
G
F
S
V
T
Y
G
A
H
T
S
I
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
---------
D
G
E
H
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
--
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
----
E
M
----
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
-------------
G
L
I
D
E
A
L
LGKKG
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
-
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
YGQGVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
LPRLVEG
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR
1
PsiBlast_PDB
91.09
34%
-87
- C2 -
2PG0
2
?
A:
[16-383]
-----------------------------
M
F
R
A
---
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
-
W
E
K
R
G
I
I
-
P
------
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
-----
D
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
---
S
S
L
--
V
G
--
I
G
L
H
N
D
I
V
T
P
Y
------
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
-
L
A
N
-
I
S
T
T
A
V
K
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
---
D
P
Q
A
K
P
P
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
--
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
----
E
M
----
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
-------------
E
E
H
M
A
G
-----------
K
Q
I
---
V
T
E
V
S
M
A
-
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.12
34%
-87
- C2 -
2PG0
2
?
B:
[16-383]
-----------------------------
M
F
R
A
---
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
-
W
E
K
R
G
I
I
-
P
------
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
-----
D
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
---
S
S
L
--
V
G
--
I
G
L
H
N
D
I
V
T
P
Y
------
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
-
L
A
N
-
I
S
T
T
A
V
K
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
---
D
P
Q
A
K
P
P
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
--
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
----
E
M
----
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
-------------
E
E
H
M
A
G
-----------
K
Q
I
---
V
T
E
V
S
M
A
-
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.59
32%
-76
- C2 -
1JQI
4
ACADS_RAT
A:
[9-383]
----------------------
E
L
P
E
T
H
Q
M
L
R
Q
---
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
-
L
D
K
E
H
L
F
-
P
--
T
S
Q
V
K
K
M
-
G
E
L
G
L
---
L
A
M
D
V
P
E
E
L
S
G
A
-------------
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
--
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
--
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
-
G
A
-
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
-----
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
--
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
----
D
M
----
A
L
A
L
E
S
A
R
L
L
T
W
R
A
--------------
A
M
L
K
D
N
-----------
K
K
P
F
--
T
K
E
S
A
M
A
-
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
88.53
29%
-86
- C2 -
2Z1Q
2
?
A:
[22-430]
--------------------
V
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
-
M
E
H
G
E
L
E
L
N
--
V
P
L
M
R
K
A
-
G
E
L
G
L
L
A
I
-------------------
D
V
P
E
E
Y
G
G
L
D
L
P
K
V
I
S
T
V
V
A
E
E
--
L
S
G
S
G
G
F
S
V
T
Y
G
A
H
T
S
I
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
-
D
G
E
H
F
T
--------
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
--
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
----
E
M
----
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
LGKKG
P
E
A
V
M
A
G
-----------
I
E
E
Y
--
A
V
E
A
S
I
I
-
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
88.48
31%
-87
- C2 -
3SF6
17
?
A:
[28-402]
---------------------
A
V
L
S
A
E
E
R
E
I
R
D
---
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
-
W
Y
E
D
G
E
L
-
P
A
-
R
----
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
K
-
G
-------------
Y
G
C
A
G
--
M
S
A
V
A
Y
G
L
A
C
L
E
L
--
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
-
A
G
-
M
R
T
R
A
T
R
S
G
D
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
E
----------
G
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
--
A
R
L
P
G
A
T
-
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
----
D
M
----
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
-------------
R
Q
K
D
A
G
-----------
E
-
L
A
--
P
E
Q
V
S
L
G
-
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
---------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
88.27
31%
-89
- C2 -
1UKW
3
?
B:
[3-377]
---------------------
F
S
L
T
E
E
Q
R
Q
L
Q
A
---
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
-
Y
D
E
K
E
E
V
-
P
--
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
---------------
G
L
K
M
L
D
E
V
----
I
V
G
E
E
L
--
A
Y
A
C
M
G
I
Y
-
T
I
P
M
A
S
D
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
-
A
A
-
L
K
T
R
A
I
R
Q
G
D
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
-----
P
E
L
R
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
--
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
----
D
M
----
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
---------------
W
L
A
D
-----------
Q
G
L
P
--
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
88.27
32%
-77
- C2 -
1JQI
4
ACADS_RAT
B:
[9-383]
----------------------
E
L
P
E
T
H
Q
M
L
R
Q
---
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
-
L
D
K
E
H
L
F
-
P
--
T
S
Q
V
K
K
M
-
G
E
L
G
L
---
L
A
M
D
V
P
E
E
L
S
G
A
-------------
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
--
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
--
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
-
G
A
-
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
-----
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
--
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
----
D
M
----
A
L
A
L
E
S
A
R
L
L
T
W
R
A
--------------
A
M
L
K
D
N
-----------
K
K
P
F
--
T
K
E
S
A
M
A
-
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.97
32%
-76
- C2 -
2VIG
5
ACADS_HUMAN
A:
[6-379]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
---
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
-
V
D
K
E
H
L
F
-
P
--
A
A
Q
V
K
K
M
----
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
-------------
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
--
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
--
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
-
G
A
-
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
-----
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
--
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
----
D
M
----
A
L
A
L
E
S
A
R
L
L
T
W
R
A
--------------
A
M
L
K
D
N
-----------
K
K
P
F
--
I
K
E
A
A
M
A
-
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
86.78
30%
-87
- C2 -
1IVH
5
IVD_HUMAN
A:
[12-392]
----------------------
G
L
S
E
E
Q
R
Q
L
R
Q
---
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
-
I
D
R
S
N
E
F
-
K
N
L
R
----
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
-------------
Y
G
G
S
G
--
L
G
Y
L
E
H
V
L
V
M
E
E
I
--
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
-
V
S
-
M
K
L
K
A
E
K
K
G
N
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
L
A
A
V
P
---
A
S
R
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
--
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
----
D
M
----
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
-------------
K
A
C
D
E
G
-----------
H
-
C
T
--
A
K
D
C
A
G
V
-
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
86.77
32%
-85
- C2 -
3SF6
16
?
A:
[37-403]
------------------------------
I
R
D
---
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
D
G
E
L
P
-------
A
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
K
--------------
G
Y
G
C
A
G
M
S
A
V
A
Y
G
L
A
C
L
--
E
L
--
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
-
A
G
-
M
R
T
R
A
T
R
S
G
D
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
E
G
----------
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
-
P
D
SA
R
L
P
G
A
T
S
L
G
A
P
L
R
C
L
N
E
A
--
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
----
D
M
----
T
L
-
E
Y
G
K
G
F
L
L
A
L
H
L
-------------
G
R
Q
K
D
A
-----------
G
E
L
A
--
P
E
Q
V
S
L
G
-
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
R
--------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
86.72
31%
-88
- C2 -
3P4T
3
?
B:
[33-399]
------------------------------
L
R
K
---
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
-
W
E
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
-------------------
G
G
D
G
A
D
P
V
V
I
C
E
E
M
HY
A
G
S
P
G
G
V
Y
A
S
L
-
F
T
C
G
I
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
-
V
G
H
-
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
--
T
G
G
P
G
A
G
----
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
--
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
----
G
M
ARRI
D
V
A
R
V
Y
T
R
H
V
V
-----------------
E
R
Q
L
A
G
-----------
E
T
N
L
--
I
A
E
V
C
F
A
-
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.68
31%
-89
- C2 -
1UKW
2
?
A:
[3-377]
---------------------
F
S
L
T
E
E
Q
R
Q
L
Q
A
---
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
-
Y
D
E
K
E
E
V
-
P
--
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
---------------
G
L
K
M
L
D
E
V
----
I
V
G
E
E
L
--
A
Y
A
C
M
G
I
Y
-
T
I
P
M
A
S
D
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
-
A
A
-
L
K
T
R
A
I
R
Q
G
D
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
-----
P
E
L
R
H
K
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
--
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
----
D
M
----
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
---------------
W
L
A
D
-----------
Q
G
L
P
--
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
86.26
32%
-77
- C2 -
2VIG
7
ACADS_HUMAN
G:
[6-379]
-----------------------
L
P
E
T
H
Q
M
L
L
Q
---
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
-
V
D
K
E
H
L
F
-
P
--
A
A
Q
V
K
K
M
----
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
-------------
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
--
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
--
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
-
G
A
-
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
--------
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
--
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
----
D
M
----
A
L
A
L
E
S
A
R
L
L
T
W
R
A
--------------
A
M
L
K
D
N
-----------
K
K
P
F
--
I
K
E
A
A
M
A
-
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
86.07
31%
-89
* C2 *
3OIB
7
?
B:
[33-399]
------------------------------
L
R
K
---
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
-
W
E
R
A
G
E
I
-
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
-------------------
G
G
D
G
A
D
P
V
V
I
C
E
E
M
HY
A
G
S
P
G
G
V
Y
A
S
L
-
F
T
C
G
I
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
-
V
G
H
-
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
--
T
G
G
P
G
A
G
----
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
--
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
----
G
M
ARRI
D
V
A
R
V
Y
T
R
H
V
V
-----------------
E
R
Q
L
A
G
-----------
E
T
N
L
--
I
A
E
V
C
F
A
-
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
85.76
32%
-89
- C2 -
4KTO
4
?
A:
[32-408]
----------------------
A
L
G
E
E
I
D
A
L
R
A
---
S
V
R
R
F
A
S
E
R
I
A
P
L
A
D
D
-
A
D
R
S
N
A
F
-
P
--
M
----
S
L
W
R
E
M
G
E
L
G
L
L
G
I
T
A
D
E
A
-------------
H
G
G
A
G
--
L
G
Y
L
A
H
C
V
A
M
E
E
I
--
S
R
A
S
A
S
V
G
L
S
Y
G
A
H
S
N
L
C
V
N
Q
I
N
R
N
G
K
P
A
Q
K
S
R
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
E
P
G
------
V
S
-
M
K
L
K
A
D
K
R
G
D
R
Y
V
L
N
G
S
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
D
P
--------
P
R
G
I
T
A
F
L
V
E
K
A
F
P
G
F
S
A
G
Q
K
L
D
K
L
G
M
R
G
S
N
T
S
E
L
I
F
T
D
C
E
V
P
E
E
--
N
V
L
G
G
V
G
E
G
V
K
V
L
M
S
G
L
D
Y
E
R
V
V
L
S
A
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
L
H
E
R
K
Q
F
G
Q
P
I
G
E
F
Q
L
M
Q
G
K
L
A
----
D
M
----
Y
V
T
M
N
A
A
R
A
Y
V
Y
A
V
A
-------------
A
A
C
D
R
G
-----------
E
-
T
A
--
R
K
D
A
A
G
C
-
I
L
Y
A
A
E
K
A
T
A
M
A
L
E
A
I
Q
A
L
G
G
N
G
Y
T
N
D
Y
P
A
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
F
A
E
------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
85.59
33%
-88
- C2 -
3NF4
1
?
A:
[14-386]
---------------------
L
L
P
S
Q
E
A
A
E
L
I
E
---
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
-
H
E
K
D
E
T
Y
-
P
--
E
----
G
V
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
E
E
-------------
W
G
G
G
G
--
Q
P
Y
E
V
Y
L
Q
V
L
E
E
I
--
A
A
R
W
A
S
V
A
V
A
V
S
V
H
S
-
L
S
S
H
P
L
L
V
F
G
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
-
A
A
-
L
R
C
A
A
T
P
T
D
G
G
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
G
---------
S
R
G
V
S
C
F
L
V
P
A
D
Q
P
G
L
S
F
G
K
P
E
E
K
M
G
L
H
A
V
P
T
T
S
A
F
Y
D
N
A
R
I
D
A
D
--
R
R
I
G
E
E
G
Q
G
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
----
D
M
----
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
-------------
R
R
R
D
Q
G
-----------
R
-
P
Y
--
S
Q
Q
A
S
I
A
-
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
R
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
R
L
V
I
A
R
G
L
T
--------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.50
29%
-84
- C2 -
2JIF
9
ACDSB_HUMAN
A:
[29-403]
-----------------------
F
T
D
E
E
M
M
I
K
S
---
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
-
M
D
E
N
S
K
M
-
E
--
K
S
V
I
Q
G
L
F
-------------
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
S
F
-----
L
S
T
V
L
V
-
I
E
E
L
--
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
--
L
K
T
R
A
D
K
E
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
---
M
A
N
V
D
P
T
I
G
Y
K
G
--
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
--
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
----
E
A
A
R
L
----
L
T
Y
N
A
A
-------------
R
L
L
E
A
G
-----------
K
P
F
---
I
K
E
A
S
M
A
-
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
85.27
28%
-84
- C2 -
2JIF
9
ACDSB_HUMAN
A:
[28-403]
----------------------
T
F
T
D
E
E
M
M
I
K
S
---
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
-
M
D
E
N
S
K
M
-
E
--
K
----
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
-------------
Y
G
G
T
G
--
A
S
F
L
S
T
V
L
V
I
E
E
L
--
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
-
F
A
-
L
K
T
R
A
D
K
E
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
I
G
-----
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
--
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
----
H
V
----
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
-------------
R
L
L
E
A
G
-----------
K
-
P
F
--
I
K
E
A
S
M
A
-
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------
73
Fugue
84.50
32%
-77
- C2 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
-------------------M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
---
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
-
R
D
H
K
G
---
I
--
Y
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
D
G
G
------------
D
V
L
S
Y
I
L
A
V
E
E
L
--
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
-
Q
T
I
A
T
K
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
S
---
K
--
G
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
--
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
----
D
M
----
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
-------------
C
K
K
Q
E
G
-----------
K
P
-
F
--
T
V
D
A
A
I
A
-
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.33
38%
-86
- C2 -
1BUC
3
ACDS_MEGEL
B:
[76-382]
---------------------------------------------------------------------------------------------------------------------
V
E
E
L
--
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
-
Q
T
I
A
T
K
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
-
M
T
D
K
S
K
G
----
N
H
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
--
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
----
D
M
----
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
-------------
C
K
K
Q
E
G
-----------
K
P
F
T
--
V
-
D
A
A
I
A
-
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
--------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
72.91
35%
-76
- C2 -
4L1F
5
?
B:
[73-378]
---------------------------------------------------------------------------------------------------------------------
V
E
E
L
--
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
-
Q
T
T
A
V
L
K
-
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
G
V
-----
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
--
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
----
D
M
----
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
-------------
M
L
K
N
E
G
-----------
K
P
Y
S
--
E
A
A
A
M
A
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
--------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.10
35%
-77
- C2 -
4L1F
6
?
A:
[73-378]
---------------------------------------------------------------------------------------------------------------------
V
E
E
L
--
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
-
Q
T
T
A
V
L
K
-
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
G
V
-----
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
--
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
----
D
M
----
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
-------------
M
L
K
N
E
G
-----------
K
P
Y
S
--
E
A
A
A
M
A
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
--------------------------------------------------------------------------------------------------------------------------------------------