@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2793c: (2016-05-13 )
MSATGPGIVVIDKPAGMTSHDVVGRCRRIFATRRVGHAGTLDPMATGVLVIGIERATKILGLLTAAPKSYAATIRLGQTTSTEDAEGQVLQSVPAKHLTIEAIDAAMERLRGEIRQVPSSVSAIKVGGRRAYRLARQGRSVQLEARPIRIDRFELLAARRRDQLIDIDVEIDCSSGTYIRALARDLGDALGVGGHVTALRRTRVGRFELDQARSLDDLAERPALSLSLDEACLLMFARRDLTAAEASAAANGRSLPAVGIDGVYAACDADGRVIALLRDEGSRTRSVAVLRPATMHPG
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90-........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.-.-......-220-------------.-...-.--------...230----.........240.......250.......260-------.---.......-.270.......280.-----------.----......290......------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSATG
P
G
I
V
V
I
DKPAGMT
S
H
D
V
V
G
R
C
R
R
I
F
A
TRRVGHAGTLDPMAT
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
TAAPK
S
Y
A
A
T
I
R
LGQTTSTEDAE
G
Q
V
L
Q
-SVPAKH
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
R
QVPSSV
S
A
I
KVG
G
R
R
A
Y
R
L
A
RQG
R
S
V
Q
L
E
ARP
I
R
I
D
R
F
E
L
L
A
A
RRRD
Q
L
I
D
I
D
V
E
I
DCSS
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
LGVGG
H
V
T
A
L
R
R
TRVGRFE
L
D
-QA-R-
S
L
D
D
L
A
-ER--------------P-ALS-L--------
S
L
D
E
------
A
C
L
L
M
F
A
RRDL
T
A
A
E
ASAAANGRSLPAVGI---------D---
G
V
Y
A
ACD-AD
G
R
V
I
A
L
LRDEG-S-----------R----
T
R
S
V
A
V
LRPATMHPG------
1
PsiBlast_PDB
98.42
100%
-125
- C6 -
1SGV
-
TRUB_MYCTU
A:
[3-292]
--
A
T
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
-
S
V
P
A
K
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
----------------------------
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
R
D
Q
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
-
Q
A
-
R
-
S
L
D
D
L
A
-
E
R
--------------
P
-
A
L
S
-
L
--------
S
L
D
E
------
A
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
G
I
---------
D
---
G
V
Y
A
A
C
D
-
A
D
G
R
V
I
A
L
L
R
D
E
G
-
S
-----------
R
----
T
R
S
V
A
V
L
R
P
------------
29
HHSearch
96.75
95%
-122
- C6 -
1SGV
-
TRUB_MYCTU
A:
[3-292]
--
A
T
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
-
A
K
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
----------------------------
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
R
D
Q
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
-
Q
A
-
R
-
S
L
D
D
L
A
-
E
R
--------------
P
-
A
L
S
-
L
--------
S
L
D
E
------
A
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
G
I
---------
D
---
G
V
Y
A
A
C
D
-
A
D
G
R
V
I
A
L
L
R
D
E
G
-
S
-----------
R
T
R
S
V
A
V
L
R
P
----------------
51
Fugue
91.70
88%
-112
- C6 -
1SGV
-
TRUB_MYCTU
A:
[3-292]
--
A
T
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
-
S
V
P
A
K
H
L
T
----
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
R
D
------------------------
Q
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
-
Q
A
-
R
-
S
L
D
D
L
A
-
E
R
--------------
P
-
A
L
S
-
L
--------
S
L
D
E
------
A
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
G
I
---------
D
---
G
V
Y
A
A
C
D
-
A
D
G
R
V
I
A
L
L
R
D
E
G
-
S
-----------
R
----
T
R
S
V
A
V
L
R
P
------------
32
HHSearch
75.63
32%
-103
* C6 *
2APO
2
TRUB_METJA
A:
[63-350]
--
L
I
K
Y
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
H
R
-------------------
D
A
S
E
E
D
I
L
R
V
F
K
E
F
T
G
R
I
Y
Q
R
----------------------------
R
I
R
K
I
H
E
L
E
L
L
D
K
D
G
----
K
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
E
K
-
D
A
-
V
-
Y
L
Q
D
L
L
-
D
A
Y
V
F
W
K
EDGDE
E
E
--
L
-
R
R
V
-
I
--------
K
P
M
E
------
Y
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
V
Y
V
R
G
I
A
K
L
S
K
GIGK
G
---
E
T
V
L
V
E
T
-
L
K
G
E
A
V
A
V
G
K
A
L
M
-
N
T
K
E
I
L
N
ADKGV
A
----
V
D
V
E
R
V
Y
M
D
R
G
T
Y
P
-------
34
HHSearch
75.43
34%
-124
- C6 -
2AUS
2
TRUB_PYRAB
C:
[44-303]
---
I
Q
Y
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
R
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
R
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
-------------------
D
V
P
E
D
K
I
R
A
V
M
K
E
F
E
G
E
I
I
Q
R
-----------------------------
T
R
K
V
Y
Y
I
E
I
L
E
I
D
G
----
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
A
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
V
-
T
L
H
D
L
V
-
D
Y
Y
H
F
W
KEDGIE
E
Y
--
I
-
R
K
A
-
I
--------
Q
P
M
E
------
K
A
V
E
H
L
P
K
I
W
I
K
D
S
A
V
A
A
V
A
H
G
A
N
L
T
V
P
G
I
V
K
L
N
A
GIKK
G
---
D
L
V
A
I
M
T
-
L
K
D
E
L
V
A
L
G
K
A
M
----------------------------------------
31
HHSearch
74.47
34%
-92
- C6 -
1R3E
3
TRUB_THEMA
A:
[1-287]
---
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
--
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
----
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
-
P
E
E
-------------
I
E
N
R
I
-
I
--------
P
L
E
-------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEWDGFKK-
G
---
E
V
V
R
V
F
N
-
E
E
G
R
L
L
A
L
A
E
A
E
R
-
N
-------------------------------------
30
HHSearch
74.31
33%
-86
- C6 -
1K8W
11
TRUB_ECOLI
A:
[22-325]
--
M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
-
V
-
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
G
----
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
R
-
E
L
V
E
Q
A
E
Q
Q
DIP
A
A
E
L
L
-
D
P
L
-
L
--------
M
P
M
D
------
S
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
PL-------
E
---
G
L
V
R
V
T
E
G
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
-----------
R
----
V
A
P
R
R
L
V
V
E
Y
-----------
52
Fugue
73.86
32%
-85
- C6 -
1R3E
3
TRUB_THEMA
A:
[1-309]
---
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
-
P
E
--------------
E
-
I
E
N
R
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEWDGFKK-
G
---
E
V
V
R
V
F
N
-
E
E
G
R
L
L
A
L
A
E
A
E
R
-
N
-----------
S
----
S
F
L
E
T
L
R
K
E
R
V
L
T
L
R
KVFNTR
50
Fugue
73.51
34%
-86
- C6 -
1K8W
11
TRUB_ECOLI
A:
[22-324]
M
D
I
N
G
--
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
-
E
R
P
-
V
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
G
N
----
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
R
-
E
L
--------------
V
-
E
Q
A
-
E
Q
Q
DIP
A
A
E
L
L
D
P
L
LMPMD
S
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
---------
P
LE
G
L
V
R
V
T
E
G
-
E
N
G
K
F
I
G
M
G
E
I
D
D
-
E
-----------
G
----
R
-----
V
A
P
R
R
L
V
V
E
------
5
PsiBlast_PDB
72.04
34%
-87
- C6 -
1R3E
3
TRUB_THEMA
A:
[4-276]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEW------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
7
PsiBlast_PDB
71.55
34%
-95
- C6 -
1ZE2
2
TRUB_THEMA
A:
[4-280]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEW------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
23
PsiBlast_CBE
70.36
34%
-83
- C6 -
1ZE1
1
TRUB_THEMA
B:
[4-272]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
W
------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
6
PsiBlast_PDB
70.11
34%
-84
- C6 -
1ZE1
1
TRUB_THEMA
A:
[4-272]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEW------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
4
PsiBlast_PDB
69.99
42%
-82
- C6 -
1ZL3
3
TRUB_ECOLI
A:
[26-234]
------
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
N
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
-
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
--
Y
E
L
L
F
I
R
H
E
G
N
--
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
R
-
E
-----------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.46
28%
-100
- C6 -
3U28
-
CBF5_YEAST
A:
[56-347]
--
Y
I
S
S
G
V
I
N
L
D
K
P
S
N
P
S
S
H
E
V
V
A
W
I
K
R
I
L
R
C
E
K
T
G
H
S
G
T
L
D
P
K
V
T
G
C
L
I
V
C
I
D
R
A
T
R
L
V
K
S
Q
Q
G
A
G
K
E
Y
V
C
I
V
R
L
H
D
A
L
------------------
K
D
E
K
D
L
G
R
S
L
E
N
L
T
G
A
L
F
Q
R
P
P
-----
K
R
Q
-----------------
L
R
V
R
T
I
Y
E
S
N
L
I
E
F
D
N
K
--
R
N
L
G
V
F
W
A
S
C
E
A
G
T
Y
M
R
T
L
C
V
H
L
G
M
L
L
G
V
G
G
H
M
Q
E
L
R
R
V
R
S
G
A
L
S
E
N
D
N
M
-
V
-
T
L
H
D
V
M
-
D
A
Q
W
V
Y
D
N
TRDE
S
Y
--
L
-
R
S
I
-
I
--------
Q
P
L
E
------
T
L
L
V
G
Y
K
R
I
V
V
K
D
S
A
V
N
A
V
C
Y
G
A
K
L
M
I
P
G
L
L
R
Y
E
E
GIEL
Y
---
D
E
I
V
L
I
T
-
T
K
G
E
A
I
A
V
A
I
A
Q
M
-
S
T
V
D
L
A
S
CDHGV
V
----
A
S
V
K
R
C
I
M
E
R
D
L
Y
P
-------
8
PsiBlast_PDB
69.20
33%
-84
- C6 -
2AB4
2
TRUB_THEMA
A:
[4-280]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
F
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
W
------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
2
PsiBlast_PDB
69.14
42%
-85
- C6 -
1K8W
8
TRUB_ECOLI
A:
[26-234]
------
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
-
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
--
Y
E
L
L
F
I
R
H
E
G
N
--
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
R
-
E
-----------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
67.99
34%
-81
- C6 -
1ZE1
1
TRUB_THEMA
C:
[4-272]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEW------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
21
PsiBlast_CBE
67.25
34%
-89
- C6 -
1ZE1
1
TRUB_THEMA
D:
[4-272]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
-
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
------------------------
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
G
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEW------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------
27
PsiBlast_CBE
66.56
32%
-103
- C6 -
3LWR
1
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
19
PsiBlast_PDB
65.20
32%
-106
- C6 -
3LWP
1
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
18
PsiBlast_PDB
64.93
32%
-100
- C6 -
3LWO
1
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
26
PsiBlast_CBE
64.42
32%
-102
- C6 -
3LWV
1
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
16
PsiBlast_PDB
64.40
32%
-97
- C6 -
3HAX
5
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
---
R
R
--------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
11
PsiBlast_PDB
64.26
32%
-95
- C6 -
3HJW
2
TRUB_PYRFU
A:
[40-248]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
---
R
R
--------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
12
PsiBlast_PDB
63.95
32%
-104
- C6 -
3HJY
3
TRUB_PYRFU
A:
[40-248]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
20
PsiBlast_PDB
63.83
32%
-101
- C6 -
3LWQ
1
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
28
PsiBlast_CBE
61.01
31%
-90
- C6 -
2RFK
1
TRUB_PYRFU
A:
[43-251]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
A
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
---
R
R
--------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
17
PsiBlast_PDB
60.82
32%
-93
- C6 -
3HAY
1
TRUB_PYRFU
A:
[47-255]
------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
D
V
P
----
E
D
K
I
I
Q
---------------
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
---
R
R
--------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
G
R
D
V
L
F
R
V
G
V
E
----
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
-
D
------------------
Y
Y
-
Y
--------
F
W
K
E
------
D
G
I
E
E
Y
F
R
K
A
I
Q
P
M
E
K
A
V
----
E
H
L
P
K
V
W
I
-------------------------------------------------------------------------
24
PsiBlast_CBE
55.69
34%
-83
- C6 -
1ZE2
2
TRUB_THEMA
B:
[4-291]
------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
------------------------------------------
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
----------------
R
V
E
V
S
P
G
T
Y
I
R
-------------------
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
A
P
E
E
--------------
I
-
E
N
R
-
I
--------
I
P
L
E
------
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
KEW------
D
---
G
F
------
K
K
G
E
V
V
R
V
F
N
E
E
G
---------------------------------------