@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2845c: (2016-05-14 )
MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSWLPLGLRVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLKDRRGNDYLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDEARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRYVIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVTARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEADLGRTVTAADTLKNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFAKHPFLVKGYIGPKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLVAGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDAFTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPFDVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSGQTRELVAGASLATDIAAAVTG
Atome Classification :
(20 SA)
.........10........20........30-....--.--...40........50........60........70........80.--.-.-.-....-90........100---.----.----......110.......120.......130.......140.....-..150......-.160.......-170.......180......-.-190-..-......200.......210.......220.....--..230.......240.......250.......260.......270---........280.......290.......300.....-..310.......320--........330.......340..-.....350.......-360.....--..370.......380.......390.......400.......410----------........420...-....430.......440...--....450-...--.....460.......470.......480.......490---..-...--------.-.500.......510-.--......520-.-......530.......540...-.-...550.......560-.......570.......580------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIT
R
M
S
E
L
F
L
R
T
LRDDPADAEVAS
H
K
L
L
I
R
A-GYIR--P--VA
P
G
L
Y
S
W
L
P
L
G
L
R
V
L
R
N
I
E
R
V
I
R
D
E
M
N
AIGGQ
E
I
L
F
P
A
LLPRAPY--E-T-T-N
R
W
T
-QYGD
S
V
F
R
L
KDR----R----G----N
D
Y
LLGPT
H
E
E
L
F
T
L
T
V
KGEYSSYKDF
P
L
T
L
Y
Q
I
Q
T
K
YRDEARP-
R
A
G
I
L
R
A
R
E
F
V
-MKDSYSFDID
A
-
A
G
L
K
A
A
Y
H
A
H
R
E
A
Y
Q
R
I
F
D
-
R
-
L
-
Q
-
V
R
-
Y
V
I
V
S
A
VSGAMGGS
A
S
E
E
F
L
AESPS
G
E
D
A
F
V
R
C
L
--
E
SGYAAN
V
E
A
V
V
TARPDTLPIDGL
P
E
A
V
VHDTGD
T
P
T
I
A
S
L
V
A
W----ANEADLG
R
T
V
T
A
A
D
T
L
K
N
V
L
I
K
V
RQPGGD
T
E
L
L
A
I
G-VPGDREV
D
D
K
R
LGA---ALEPA
D
Y
A
LLDDDDFAKH
P
F
L
V
K-GYI
G
P
K
A
LRENN
V
R
Y
-
L
VD
P
R
IVD--GTSWITGADQPG
R
H
V
V
G
L
VAGRDFTADG
T
I
E
A
AEVREGDPSPDG-----------AG
P
L
V
M
A
RGIEIG
H
-
I
F
Q
LGSKYTD
A
F
T
A
D
V
LGED--G
K
P
V
R
L
--
T
MG--SYG
I
G
V
S
R
L
V
A
V
V
A
E
Q
H
H
D
E
LGLRWPSTVA
P
F
D
V
H
L
V
I
---AN-KDA--------Q-ARAG
A
T
A
L
A
A
D
L
D
R-L--G
V
E
V
L
L
DDR-Q-ASPGVKFKDAELLGM
P
W
I
V
V
VG-R-GWA
D
G
V
V
E
L
R
D
RFSG
Q
-
T
R
E
L
VAG
A
S
L
A
T
D
I
A
A
AVTG------------------------------------------------------------------------------------------
66
Fugue
94.16
41%
-85
- C1 -
2J3L
11
SYP_ENTFA
A:
[1-565]
--
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
-
G
Y
I
R
--
Q
--
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
-
G
R
Y
E
-
T
Y
G
P
N
L
Y
R
L
K
D
R
----
N
----
D
----
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
-
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
-
G
-
L
E
-
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
--
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
----
F
E
-------
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
D
E
-----
E
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
K
N
---
F
L
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
-
G
S
I
G
P
V
N
V
-
S
E
D
V
K
I
-
Y
A
D
L
A
V
Q
D
--
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
-----------
N
G
V
L
A
F
T
K
G
I
E
I
G
H
-
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
--
G
R
E
K
S
V
--
I
M
G
--
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
---
M
N
V
K
D
E
--------
Y
-
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
-
A
--
G
Y
E
V
L
V
D
D
R
-
N
-
E
R
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
-
K
-
K
A
V
D
G
V
V
E
V
K
I
K
R
T
G
E
-
M
L
E
V
R
-
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.54
41%
-81
- C1 -
2J3L
11
SYP_ENTFA
A:
[2-552]
---
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
-
G
Y
I
R
--
Q
--
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
-
G
R
Y
E
-
T
Y
G
P
N
L
Y
R
L
K
D
R
----
N
----
D
----
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
-
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
-
G
-
L
E
-
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
--
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
---
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
----
A
N
F
F
E
----
V
E
P
Q
R
I
I
K
S
V
L
F
I
-----
A
D
E
E
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
K
N
---
F
L
-
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
-
D
V
K
I
-
Y
A
D
L
A
V
Q
D
--
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
-----------
N
G
V
L
A
F
T
K
G
I
E
I
G
H
-
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
--
G
R
E
K
S
V
--
I
M
G
--
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
---
M
N
V
K
D
E
--------
Y
-
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
-
A
--
G
Y
E
V
L
V
D
D
R
-
N
-
E
R
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
-
K
-
K
A
V
D
G
V
V
E
V
K
I
K
R
T
G
E
-
M
L
E
V
----------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.12
41%
-82
- C1 -
2J3L
13
SYP_ENTFA
B:
[2-552]
---
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
-
G
Y
I
R
--
Q
--
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
-
G
R
Y
E
-
T
Y
G
P
N
L
Y
R
L
K
D
R
----
N
----
D
----
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
-
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
-
G
-
L
E
-
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
--
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
---
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
----
A
N
F
F
E
----
V
E
P
Q
R
I
I
K
S
V
L
F
I
-----
A
D
E
E
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
K
N
---
F
L
-
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
-
D
V
K
I
-
Y
A
D
L
A
V
Q
D
--
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
-----------
N
G
V
L
A
F
T
K
G
I
E
I
G
H
-
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
--
G
R
E
K
S
V
--
I
M
G
--
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
---
M
N
V
K
D
E
--------
Y
-
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
-
A
--
G
Y
E
V
L
V
D
D
R
-
N
-
E
R
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
-
K
-
K
A
V
D
G
V
V
E
V
K
I
K
R
T
G
E
-
M
L
E
V
----------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.26
41%
-80
- C1 -
2J3M
5
SYP_ENTFA
B:
[2-552]
---
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
-
G
Y
I
R
--
Q
--
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
-
G
R
Y
E
-
T
Y
G
P
N
L
Y
R
L
K
D
R
----
N
----
D
----
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
-
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
-
G
-
L
E
-
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
--
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
---
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
----
A
N
F
F
E
----
V
E
P
Q
R
I
I
K
S
V
L
F
I
-----
A
D
E
E
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
K
N
---
F
L
-
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
-
D
V
K
I
-
Y
A
D
L
A
V
Q
D
--
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
-----------
N
G
V
L
A
F
T
K
G
I
E
I
G
H
-
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
--
G
R
E
K
S
V
--
I
M
G
--
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
---
M
N
V
K
D
E
--------
Y
-
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
-
A
--
G
Y
E
V
L
V
D
D
R
-
N
-
E
R
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
-
K
-
K
A
V
D
G
V
V
E
V
K
I
K
R
T
G
E
-
M
L
E
V
----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.45
41%
-80
- C1 -
2J3M
5
SYP_ENTFA
A:
[2-552]
---
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
-
G
Y
I
R
--
Q
--
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
-
G
R
Y
E
-
T
Y
G
P
N
L
Y
R
L
K
D
R
----
N
----
D
----
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
-
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
-
G
-
L
E
-
F
R
A
I
I
G
D
----
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
--
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
---
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
----
A
N
F
F
E
----
V
E
P
Q
R
I
I
K
S
V
L
F
I
-----
A
D
E
E
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
K
N
---
F
L
-
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
-
D
V
K
I
-
Y
A
D
L
A
V
Q
D
--
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
-----------
N
G
V
L
A
F
T
K
G
I
E
I
G
H
-
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
--
G
R
E
K
S
V
--
I
M
G
--
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
---
M
N
V
K
D
E
--------
Y
-
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
-
A
--
G
Y
E
V
L
V
D
D
R
-
N
-
E
R
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
-
K
-
K
A
V
D
G
V
V
E
V
K
I
K
R
T
G
E
-
M
L
E
V
----------------------------------------------------------------------------------------------------------
44
HHSearch
90.82
39%
-80
* C1 *
2J3L
11
SYP_ENTFA
A:
[1-565]
--
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
-
G
Y
I
R
--
Q
--
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
-
G
R
Y
E
-
T
Y
G
P
N
L
Y
R
L
K
D
R
----
N
----
D
----
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
-
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
-
G
-
L
E
-
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
--
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
----
F
E
V
E
-------
P
Q
R
I
I
K
S
V
L
F
I
A
-----
D
E
E
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
K
N
---
F
L
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
-
G
S
I
G
P
V
N
V
S
-
E
D
V
K
I
-
Y
A
D
L
A
V
Q
D
--
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
-
M
G
A
T
V
L
-----------
D
E
N
--
G
R
E
K
S
V
--
I
M
G
--
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
---
M
N
-
V
K
D
--------
E
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
-
A
--
G
Y
E
V
L
V
D
D
R
-
N
-
E
R
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
-
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
-
M
-
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
48
HHSearch
66.37
24%
-87
- C1 -
1NJ8
-
SYP_METJA
A:
[6-375]
-----------------------
W
Y
S
D
I
L
E
K
A
E
I
Y
D
--
V
RY
P
I
K
G
C
G
V
Y
L
P
Y
G
F
K
I
R
R
Y
T
F
E
I
I
R
N
L
L
D
E
S
G
H
D
E
A
L
F
P
M
L
I
P
E
D
L
L
--
A
-
K
E
A
-
E
H
I
K
-
G
F
E
D
E
V
Y
W
V
T
H
G
----
G
KTQL
D
----
V
K
L
A
L
R
P
T
S
E
T
P
I
Y
Y
M
M
K
L
W
V
K
V
H
T
D
L
P
I
K
I
Y
Q
I
V
N
T
F
R
Y
E
T
K
H
-
T
R
P
L
I
R
L
R
E
I
M
T
F
K
E
A
H
T
A
H
S
T
K
-
E
E
A
E
N
Q
V
K
E
A
I
S
I
Y
K
K
F
F
D
-
T
-
L
-
G
-
I
P
-
Y
L
I
S
K
R
P
--------
E
W
-------------------------
D
------------------
K
F
-----------------------------------------------------------
P
G
--------------------------------------
A
E
Y
T
M
-----------------------------------
A
F
D
T
I
F
---------------------
P
D
------------------
G
R
T
M
Q
I
A
T
-
V
H
N
L
G
Q
N
F
S
K
T
F
E
I
I
F
E
T
P
T
--
G
D
K
D
Y
A
--
Y
Q
T
--
C
Y
G
I
S
-
D
R
V
I
A
S
I
I
A
I
H
G
D
E
K
G
L
I
L
P
P
I
V
A
P
I
Q
V
V
I
V
P
---
L
I
-
F
K
G
K
E
D
-----
I
-
V
M
E
K
A
K
E
I
Y
E
K
L
K
--
G
--
K
F
R
V
H
I
D
D
R
-
D
-
I
R
P
G
R
K
F
N
D
W
E
I
K
G
V
P
L
R
I
E
V
G
-
P
K
D
I
E
N
K
K
I
T
L
F
R
R
D
T
M
E
-
K
-
F
Q
V
D
E
T
Q
L
M
E
V
V
E
K
T
L
--------------------------------------------------------------------------------------------
50
HHSearch
65.99
22%
-87
- C1 -
1HC7
-
SYP_THET8
A:
[15-384]
---------------------
S
E
W
Y
L
E
V
I
Q
K
A
E
L
A
D
--
Y
G
-
P
V
R
G
T
I
V
V
R
P
Y
G
Y
A
I
W
E
N
I
Q
Q
V
L
D
R
M
F
K
E
T
G
H
Q
N
A
Y
F
P
L
F
I
P
M
S
F
L
--------------
F
S
P
E
L
A
V
V
T
H
A
----
G
GEEL
E
----
E
P
L
A
V
R
P
T
S
E
T
V
I
G
Y
M
W
S
K
W
I
R
S
W
R
D
L
P
Q
L
L
N
Q
W
G
N
V
V
R
W
E
M
R
T
--
R
P
F
L
R
T
S
E
F
L
-
W
Q
E
G
H
T
A
H
A
T
R
-
E
E
A
E
E
E
V
R
R
M
L
S
I
Y
A
R
L
A
R
-
E
-
Y
-
A
A
I
P
-
V
I
E
--------
G
---------------------------
L
--
K
-----
T
-------------------
E
----
K
---------------------------------------
E
K
F
------
A
G
--------------------------------------
A
V
Y
T
T
-----------
T
I
E
A
L
M
K
D
---------------------------------------------------------------
G
K
A
L
Q
A
G
T
-
S
H
Y
L
G
E
N
F
A
R
A
F
D
I
K
F
Q
D
R
D
--
L
Q
V
K
Y
V
--
H
T
T
--
S
W
G
L
S
-
W
R
F
I
G
A
I
I
M
T
H
G
D
D
R
G
L
V
L
P
P
R
L
A
P
I
Q
V
V
I
V
P
---
I
Y
-
K
D
E
S
R
E
-----
R
-
V
L
E
A
A
Q
G
L
R
Q
A
L
L
A
-
Q
--
G
L
R
V
H
L
D
D
R
-
D
Q
H
T
P
G
Y
K
F
H
E
W
E
L
K
G
V
P
F
R
V
E
L
G
-
P
K
D
L
E
G
G
Q
A
V
L
A
S
R
L
G
G
--
K
-
E
T
L
P
L
A
A
L
P
E
A
L
P
G
K
---------------------------------------------------------------------------------------------
68
Fugue
65.40
23%
-81
- C1 -
1HC7
1
SYP_THET8
A:
[5-477]
----------
K
G
L
T
P
Q
S
Q
D
F
S
E
W
Y
L
E
V
I
Q
K
A
-
E
L
A
D
Y
-
G
--
P
V
R
G
T
I
V
V
R
P
Y
G
Y
A
I
W
E
N
I
Q
Q
V
L
D
R
M
F
K
E
T
G
H
Q
N
A
Y
F
P
L
F
I
P
M
S
F
L
FS
P
-
E
-
L
-
A
V
V
T
-
H
A
G
------
G
E
E
----
L
----
E
----
E
P
L
A
V
R
P
T
S
E
T
V
I
G
Y
M
W
S
K
W
I
R
S
W
R
D
L
P
Q
L
L
N
Q
W
G
N
V
V
R
W
E
M
R
T
-
R
P
-
F
L
R
T
S
E
F
L
-
W
Q
E
G
H
T
A
H
A
T
R
-
E
E
A
E
E
E
V
R
R
M
L
S
I
Y
A
R
L
A
R
-
E
-
Y
-
A
-
A
I
-
P
V
I
E
G
L
K
T
--------------------
E
K
E
K
F
A
--
G
A
V
Y
T
T
T
I
E
A
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
G
------------------
K
A
L
Q
A
G
T
-
S
H
Y
L
G
E
N
F
A
R
A
F
D
I
K
F
Q
D
R
D
--
L
Q
V
K
Y
V
--
H
T
T
--
S
W
G
L
S
-
W
R
F
I
G
A
I
I
M
T
H
G
D
D
R
G
L
V
L
P
P
R
L
A
P
I
Q
V
V
I
V
P
I
Y
K
D
E
-
S
R
E
--------
R
-
V
L
E
A
A
Q
G
L
R
Q
A
L
L
A
-
Q
--
G
L
R
V
H
L
D
D
R
D
Q
-
H
T
P
G
Y
K
F
H
E
W
E
L
K
G
V
P
F
R
V
E
L
G
P
K
-
D
L
E
G
G
Q
A
V
L
A
S
R
L
G
G
---
K
E
T
L
P
L
A
A
L
P
E
A
L
P
G
K
L
D
A
F
H
E
E
L
Y
R
R
A
L
A
F
R
E
D
H
T
R
K
V
DT
Y
E
A
F
K
E
A
V
Q
E
G
F
A
L
A
F
H
CGD
K
A
C
E
R
L
I
Q
E
E
TTATTRCVPFEAE
P
E
E
G
F
CVRCGRPSAYG
K
R
V
V
F
A
KAY
57
HHSearch
64.68
20%
-92
- C1 -
4HVC
3
SYEP_HUMAN
A:
[37-424]
-------------------------
Q
V
I
T
K
S
-
E
M
I
E
--
Y
H
-
D
I
S
G
C
Y
I
L
R
P
W
A
Y
A
I
W
E
A
I
K
D
F
F
D
A
E
I
K
K
L
G
V
E
N
C
Y
F
P
M
F
V
S
Q
S
A
L
--
E
-
K
E
K
-
T
H
V
A
-
D
F
A
P
E
V
A
W
V
T
R
S
----
G
----
K
TELA
E
P
I
A
I
R
P
T
S
E
T
V
M
Y
P
A
Y
A
K
W
V
Q
S
H
R
D
L
P
I
K
L
N
Q
W
C
N
V
V
R
W
E
F
K
H
-
P
Q
P
F
L
R
T
R
E
F
L
-
W
Q
E
G
H
S
A
F
A
T
M
-
E
E
A
A
E
E
V
L
Q
I
L
D
L
Y
A
Q
V
Y
E
-
E
-
L
L
A
-
I
P
-
V
V
K
G
R
K
---------
T
E
--------------------------------------------
K
------------
E
---------------------------------------
K
F
------
A
G
G
--------------------------------------
D
Y
T
T
-----------------------------------
T
I
E
A
F
I
S
--------------------------------------
A
S
G
R
A
I
Q
G
G
T
-
S
H
H
L
G
Q
N
F
S
K
M
F
E
I
V
F
E
D
P
K
IP
G
E
K
Q
F
A
--
Y
Q
N
--
S
W
G
L
-
T
T
R
T
I
G
V
M
T
M
V
H
G
D
N
M
G
L
V
L
P
P
R
V
A
C
V
Q
V
V
I
I
P
---
C
G
-
I
--LS
E
E
D
K
E
-
A
-
L
I
A
K
C
N
D
Y
R
R
R
L
L
S
-
V
--
N
I
R
V
R
A
D
L
R
-
D
N
Y
S
P
G
W
K
F
N
H
W
E
L
K
G
V
P
I
R
L
E
V
G
-
P
R
D
M
K
S
C
Q
F
V
A
V
R
R
D
T
G
E
-
K
-
L
T
V
A
E
N
E
A
E
T
K
L
Q
A
I
L
--------------------------------------------------------------------------------------------
60
HHSearch
64.48
22%
-86
- C1 -
3IAL
5
?
A:
[26-408]
----------------------
D
W
F
D
A
I
M
D
A
A
E
L
V
D
--
R
RY
P
V
K
G
C
V
V
F
R
P
Y
G
F
F
M
E
N
A
I
M
R
L
C
E
E
E
Y
A
K
V
G
I
S
Q
I
L
F
P
T
V
I
P
E
S
F
L
--
K
-
K
E
S
-
D
H
I
K
-
G
F
E
A
E
C
F
W
V
E
K
G
GLQP
L
----
E
----
E
R
L
A
L
R
P
T
S
E
T
A
I
Y
S
M
F
S
K
W
V
R
S
Y
K
D
L
P
L
K
I
H
Q
T
C
T
I
F
R
H
E
T
K
N
-
T
K
P
L
I
R
V
R
E
I
H
-
W
N
E
A
H
C
C
H
A
T
A
-
E
D
A
V
S
Q
L
S
D
Y
W
K
V
I
D
T
I
F
S
D
E
-
L
-
C
-
F
K
-
G
Q
K
L
R
R
--------------------------------------------------------------
V
---
C
--------------------
W
-------------------
D
R
F
------
P
G
--------------------------------------
A
D
Y
S
E
----------------------------
V
-------
S
D
V
V
M
---------------------------------------
P
C
G
R
V
L
Q
T
A
G
-
I
H
N
L
G
Q
R
F
S
S
T
F
D
I
L
Y
A
N
K
A
--
N
E
S
V
H
P
--
Y
L
T
--
C
A
G
I
S
-
T
R
V
L
A
C
A
L
S
I
H
G
D
S
G
G
L
V
L
P
P
L
I
A
P
I
H
V
V
I
I
P
---
I
G
-
C
G
K
KNN
Q
E
S
D
Q
Q
-
V
L
G
K
V
N
E
I
A
D
T
L
K
S
K
L
--
G
L
R
V
S
I
D
D
D
F
S
-
K
S
M
G
D
K
L
Y
Y
Y
E
L
K
G
V
P
L
R
I
E
V
G
-
Q
R
D
L
A
N
G
Q
C
I
V
V
P
R
D
V
G
K
D
Q
K
R
V
I
P
I
T
E
V
M
---------------------------------------------------------------------------------------------------
45
HHSearch
64.47
37%
-13
- C1 -
2I4L
-
SYP_RHOPA
A:
[-2-436]
-
H
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
-
G
M
L
R
--
Q
--
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
--
R
-
E
-
S
-
G
R
Y
D
-
A
Y
G
P
E
M
L
R
I
A
D
R
----
H
----
K
----
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
-
R
F
G
V
M
R
G
R
E
F
L
-
M
K
D
A
Y
S
F
D
V
D
E
-
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
-
R
-
M
-
G
-
L
K
-
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
Y
I
D
R
--
D
V
L
-
N
L
P
----
V
P
------------
D
E
N
V
-------------
D
Y
------------------------------------------
D
G
D
L
T
P
I
--------------------
I
K
Q
W
T
S
V
Y
A
A
T
--
E
D
V
H
E
P
A
--
R
Y
E
S
E
V
P
E
A
N
R
L
N
T
R
--
G
I
E
---------------------------------------------------------------
V
G
Q
-
I
F
Y
F
G
T
K
Y
S
D
S
M
K
A
N
V
T
G
P
D
--
G
T
D
A
P
I
--
H
G
G
--
S
Y
G
V
G
V
S
R
L
L
G
A
I
I
E
A
C
H
D
D
N
G
I
I
W
P
E
A
V
A
P
F
R
V
T
I
L
N
---
L
K
-
Q
G
D
A
-------
A
-
T
D
A
A
C
D
Q
L
Y
R
E
L
S
A
-
K
--
G
V
D
V
L
Y
D
D
T
-
D
-
Q
R
A
G
A
K
F
A
T
A
D
L
I
G
I
P
W
Q
I
H
V
G
-
P
R
G
L
A
E
G
K
V
E
L
K
R
R
S
D
G
A
-
R
-
E
N
L
A
L
A
D
V
V
A
R
-------------------------------------------------------------------------------------------------
62
HHSearch
64.18
18%
-84
- C1 -
1EVL
2
SYT_ECOLI
A:
[1-391]
----------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
--
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
--
E
-
K
-
T
-
G
H
W
D
-
N
Y
K
D
A
M
F
T
T
S
S
-----
E
----
N
----
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
-
Q
D
D
A
H
I
F
C
T
E
E
-
Q
I
-
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
-
T
-
F
-
G
-
F
E
-
K
I
V
V
K
L
---------
S
T
----------
R
P
E
K
R
I
-------
G
S
D
-----
E
------------
M
-----------
W
D
R
-------------------
A
E
A
D
L
A
V
A
L
E
E
----------------------------------------------------------
N
N
--------
I
P
F
---
E
Y
Q
L
G
E
--
G
A
F
Y
G
P
K
I
E
------
F
T
L
Y
D
-----------
C
L
----
D
------------------
R
A
W
Q
C
G
T
V
Q
L
D
F
S
-
L
-------
P
S
R
L
S
A
S
Y
V
G
E
D
--
N
E
R
K
V
P
--
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
----
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
---
I
T
-
D
----------
S
-
Q
S
E
Y
V
N
E
L
T
Q
K
L
S
N
-
A
--
G
I
R
V
K
A
D
L
R
-
N
-
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
-
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
-
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
--------------------------------------------------------------------------------------------
47
HHSearch
63.96
23%
-84
- C1 -
1NJ1
2
SYP_METTH
A:
[44-411]
-----------------------
F
H
N
I
L
E
E
A
-
E
I
I
D
--
Q
RY
P
V
K
G
M
H
V
W
M
P
H
G
F
M
I
R
K
N
T
L
K
I
L
R
R
I
L
D
-
R
D
H
E
E
V
L
F
P
L
L
V
P
E
D
E
L
--
A
K
E
-
A
-
I
H
V
K
-
G
F
E
D
E
V
Y
W
V
T
H
G
GLSK
L
----
Q
----
R
K
L
A
L
R
P
T
S
E
T
V
M
Y
P
M
F
A
L
W
V
R
S
H
T
D
L
P
M
R
F
Y
Q
V
V
N
T
F
R
Y
E
T
K
H
-
T
R
P
L
I
R
V
R
E
I
T
T
F
K
E
A
H
T
I
H
A
T
A
-
S
E
A
E
E
Q
V
E
R
A
V
E
I
Y
K
E
F
F
N
-
S
-
L
-
G
-
I
P
-
Y
L
I
T
R
R
P
P
--------
W
-------------------------
D
------------------
K
F
-----------------------------------------------------------
P
G
S
E
--------------------------------------
Y
----------
T
V
---
A
----------------------
F
D
T
L
---------------------
M
P
------------------
D
G
K
T
L
Q
I
G
T
-
V
H
N
L
G
Q
T
F
A
R
T
F
E
I
K
F
E
T
P
E
--
G
D
H
E
Y
V
--
H
Q
T
--
C
Y
G
L
S
-
D
R
V
I
A
S
V
I
A
I
H
G
D
E
S
G
L
C
L
P
P
D
V
A
A
H
Q
V
V
I
V
P
---
I
I
-
F
K
K
A
A
E
-----
E
-
V
M
E
A
C
R
E
L
R
S
R
L
E
A
-
A
--
G
F
R
V
H
L
D
D
R
-
D
-
I
R
A
G
R
K
Y
Y
E
W
E
M
R
G
V
P
L
R
V
E
I
G
-
P
R
D
L
E
K
G
A
A
V
I
S
R
R
D
T
G
E
-
K
-
V
T
A
D
L
Q
G
I
E
E
T
L
R
E
L
---------------------------------------------------------------------------------------------
59
HHSearch
63.46
21%
-62
- C1 -
1QF6
2
SYT_ECOLI
A:
[238-632]
------------------
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
--
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
--
E
-
K
-
T
-
G
H
W
D
-
N
Y
K
D
A
M
F
T
T
S
S
-----
E
----
N
----
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
-
Q
D
D
A
H
I
F
C
T
E
E
-
Q
-
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
-
T
-
F
-
G
-
F
E
-
K
I
V
V
K
L
---------
S
T
R
----------
P
E
K
R
I
-----
G
--
S
D
-
E
-
M
W
D
--------------------------
R
-------------------
A
E
A
D
L
A
V
A
L
E
E
N
N
---
I
P
F
E
----
Y
-
Q
L
G
E
-----------------------------------
G
-
A
F
Y
G
P
K
I
-----------
E
F
T
L
Y
D
CL
D
R
A
W
Q
C
G
T
V
Q
------
L
-----
D
------------------------------------
F
S
L
P
S
----------------
R
L
S
A
S
Y
V
G
E
D
--
N
E
R
K
V
P
--
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
----
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
---
I
T
-
D
S
-----------
Q
S
E
Y
V
N
E
L
T
Q
K
L
S
N
-
A
--
G
I
R
V
K
A
D
L
R
-
N
-
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
-
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
-
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
--------------------------------------------------------------------------------------------
49
HHSearch
61.69
19%
-100
- C1 -
4NCX
6
SYP_PLAF7
A:
[28-410]
-------------------------
Q
V
I
V
K
S
-
E
L
I
E
--
Y
Y-
D
--
G
C
Y
I
L
R
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
F
N
K
E
I
K
K
L
N
V
E
N
S
Y
F
P
L
F
V
T
---------------------------------------------------
S
E
T
I
M
Y
S
V
F
P
K
W
I
R
S
Y
R
D
L
P
L
K
L
N
Q
W
N
T
V
V
R
W
E
F
---
P
T
P
F
I
R
T
R
E
F
L
-
W
Q
E
G
H
T
A
H
K
N
E
-
E
E
A
V
K
L
V
F
D
I
L
D
L
Y
R
R
W
Y
E
-
E
Y
L
-
A
-
V
P
-
I
I
K
G
I
K
------------------------------------
S
-----
E
---------------------------------------------------
G
------------
E
K
F
------
G
G
A
-------------------------------------
N
----------------------------
F
-
T
S
T
-------
A
E
A
F
I
S
--------------------------------------
E
N
G
R
A
I
Q
A
A
T
-
S
H
Y
L
G
T
N
F
A
K
M
F
K
I
E
F
E
D
E
N
--
E
V
K
Q
Y
V
--
H
Q
T
--
S
W
G
C
-
T
T
R
S
I
G
I
M
I
M
T
H
G
D
D
K
G
L
V
L
P
P
N
V
S
K
Y
K
V
V
I
V
P
---
I
F
-
Y
K
T
TD
E
N
----
A
-
I
H
S
Y
C
K
D
I
E
K
I
L
K
N
-
A
--
Q
I
N
C
V
Y
D
D
R
-
A
S
Y
S
P
G
Y
K
F
N
H
W
E
L
R
G
I
P
I
R
I
E
V
G
-
P
K
D
L
Q
N
N
S
C
V
I
V
R
R
D
N
N
E
-
K
-
C
N
V
K
K
E
S
V
L
L
E
T
Q
Q
M
---------------------------------------------------------------------------------------------
63
HHSearch
61.43
21%
-60
- C1 -
1NYR
3
SYT_STAAW
A:
[237-639]
------------------
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
NS
Q
L-
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
--
K
-
T
-
S
-
G
H
W
D
-
H
Y
Q
E
D
M
F
P
P
M
Q
L
D---
E
----
T
----
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
-
L
N
D
S
H
I
F
V
R
P
D
--
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
K
-
D
-
F
-
G
-
F
E
-
D
Y
S
F
R
L
S
Y
R
D
P
E
D
-------------
K
E
K
----------
Y
F
D
D
D
----
D
-----------------------
M
W
N
K
-------------------
A
E
N
M
L
K
E
A
A
D
E
L
G
-------------
L
--
S
------------------------
Y
E
E
A
---
I
G
-
E
A
-
A
F
Y
G
P
K
L
-----------
D
V
Q
V
K
T
------
A
M
G
--------------
K
E
E
T
L
S
-
T
A
--------------------------
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
G
E
------------------
H
H
R
P
V
V
I
H
R
--
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
----
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
---
V
N
-
V
D
---------
L
-
H
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
-
Q
--
G
V
R
V
S
I
D
D
R
-
N
-
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
-
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
-
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
--------------------------------------------------------------------------------------------
55
HHSearch
59.04
20%
-75
- C1 -
1HTT
2
SYH_ECOLI
A:
[6-422]
-----------------------------------------
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
--
K
-
R
-
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
----
N
----
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
-
Y
N
Q
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
----
K
G
R
Y
R
Q
F
H
-
Q
L
G
C
E
V
F
G
L
Q
G
-
P
D
I
D
---
A
E
L
I
M
L
T
A
R
W
W
R
-
A
-
L
-
G
-
I
S
E
H
V
T
L
E
L
---------
N
S
----------
I
G
S
L
E
A
R
--
A
N
----------------------------------------------------------------------------------------------------
Y
L
----
D
E
E
S
-
R
E
H
F
A
G
L
C
K
L
L
--
E
S
--------
A
G
I
A
Y
-
T
V
N
Q
R
L
V
R
--
G
L
D
Y
Y
N
R
T
------
V
F
E
W
V
T
N
-----------------------------------
Q
G
T
V
C
A
G
G
R
Y
D
G
L
-
V
E
Q
L
G
G
-------------------
R
A
T
--
P
A
V
--
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
------
F
K
A
D
P
V
V
D
I
Y
L
V
A
---
S
G
-
A
D
-----------
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
-
E
L
P
G
V
K
L
M
T
N
H
G
-
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
-
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
-
Q
-
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
--------------------------------------------------------------------------------------------
46
HHSearch
57.21
18%
-77
- C1 -
4X5O
-
SYHC_HUMAN
A:
[54-502]
---------------------------------
F
V
L
--
K
--
T
P
K
G
T
R
D
Y
S
P
R
Q
M
A
V
R
E
K
V
F
D
V
I
I
R
C
F
K
R
H
G
A
E
V
I
D
T
P
V
F
E
L
K
E
T
L
--
M
-
G
-
K
--------
S
K
L
I
Y
D
L
K
D
Q
----
G
----
G
----
E
L
L
S
L
R
Y
D
L
T
V
P
F
A
R
Y
L
A
M
N
----
K
L
T
N
I
K
R
Y
H
I
A
K
V
Y
R
R
D
N
P
A
M
T
R
G
--
R
Y
R
E
F
Y
-
Q
C
D
F
D
I
A
G
N
F
D
P
M
I
P
D
---
A
E
C
L
K
I
M
C
E
I
L
S
-
S
-
L
-
Q
-
I
G
-
D
F
L
V
K
V
---------
N
D
----------
R
R
I
L
D
G
M
F
A
I
C
G
V
S
D
S
K
--
F
R
T
------------
I
C
S
S
V
D
K
L
D
K
V
S
W
E
E
V
K
N
E
M
V
GE
K
G
L
A
P
---------
E
V
A
------------
D
R
I
G
D
Y
V
Q
Q
H
G
G
V
S
L
-
V
E
Q
L
L
Q
D
P
K
L
S
Q
N
K
Q
A
L
E
G
-
L
G
D
L
K
L
L
F
E
Y
L
--
T
L
F
G
I
------
D
D
K
I
-
S
F
D
L
S
L
A
R
--
G
L
D
Y
Y
T
G
V
------
I
Y
E
A
V
L
L
-----------------------------------
V
G
S
V
A
A
G
G
R
Y
D
G
L
-
V
G
M
F
D
P
K
---------------
G
--
R
K
V
--
P
C
V
--
G
L
S
I
G
V
E
R
I
F
S
I
V
E
Q
R
L
E
A
L
E
E
-
K
I
--
R
T
T
E
T
Q
V
L
V
A
S
---
A
Q
-
K
----------
K
-
L
L
E
E
R
L
K
L
V
S
E
L
W
D
-
A
--
G
I
K
A
E
L
L
Y
K
-
K
N
P
K
L
L
N
Q
L
Q
Y
C
E
E
A
G
I
P
L
V
A
I
I
G
-
E
Q
E
L
K
D
G
V
I
K
L
R
S
V
T
S
R
E
-
E
-
V
D
V
R
R
E
D
L
V
E
E
I
K
R
R
T
--------------------------------------------------------------------------------------------
23
PsiBlast_CBE
56.99
43%
-69
- C1 -
2I4O
3
SYP_RHOPA
C:
[22-238]
---
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
-
G
M
L
R
--
Q
--
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
--
R
-
E
-
S
-
G
R
Y
D
-
A
Y
G
P
E
M
L
R
I
A
D
R
----
H
----
K
----
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
-
R
F
G
V
M
R
G
R
E
F
L
-
M
K
D
A
Y
S
F
D
V
D
E
-
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
-
R
-
M
-
G
-
L
K
-
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------