@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2857c: (2016-05-14 )
MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL
Atome Classification :
(35 SA)
.........10........20........30........---40.----.---..-.--------...50....-----.-----.-----.----..60........70........80........90..-......100.......110.......120.......130.-.-..-...140.......150.......160.......170......--.180.......190..----...----..200-------..-.....210--..-.-.....220.......230.......240.......250......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
D
L
S
Q
R
LAG
R
V
A
V
I
TGGGSGIGLAAGRRMRAEG
A
T
I
V
V
---
G
D
V
----
D
---VE-A--------GGA
A
-
A
D
E
L-----S-----G-----L----FVPTDVC
D
E
D
A
V
N
G
L
FDGAAETY
G
R
I
D
I
A
FNNAGIS-PPEDNLIENT
E
L
A
A
W
Q
R
V
QDV
N
L
K
S
V
Y
L
C
C
R
A
A
L
R
H
M
V
LA-G-KG-
S
I
V
N
T
A
S
F
V
A
V
MGSAT
S
Q
I
S
Y
TASKG
G
V
L
A
M
S
R
E
L
G
V
Q
F
A
RQ--G
I
R
V
N
A
LCPGPV
N
T
P
L
----
L
Q
E
----
L
F
AK
N
-------
P
E
-
R
A
A
R
R
M
-
V
--HV-P-LGRFA
E
P
D
E
I
A
A
A
V
A
F
LASDDA
S
F
I
T
A
S
T
F
L
VDGGISSAYVTPL
21
PsiBlast_CBE
98.11
85%
-96
- C1 -
4WEC
5
?
D:
[22-278]
-
M
D
L
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
---
G
D
I
----
D
---
P
T
-
T
--------
G
K
A
A
-
A
D
E
L
-----
E
-----
G
-----
L
----
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
-
P
P
E
D
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
--
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
----
L
Q
E
----
L
F
A
K
D
-------
P
E
-
R
A
A
R
R
L
-
V
--
H
I
-
P
-
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
Y
V
T
P
L
22
PsiBlast_CBE
97.88
85%
-99
- C1 -
4WEC
5
?
C:
[26-278]
-----
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
---
G
D
I
----
D
---
P
T
-
T
--------
G
K
A
A
-
A
D
E
L
-----
E
-----
G
-----
L
----
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
-
P
P
E
D
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
--
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
----
L
Q
E
----
L
F
A
K
D
-------
P
E
-
R
A
A
R
R
L
-
V
--
H
I
-
P
-
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
Y
V
T
P
L
1
PsiBlast_PDB
97.74
85%
-94
- C1 -
4WEC
5
?
A:
[22-278]
-
M
D
L
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
---
G
D
I
----
D
---
P
T
-
T
--------
G
K
A
A
-
A
D
E
L
-----
E
-----
G
-----
L
----
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
-
P
P
E
D
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
--
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
----
L
Q
E
----
L
F
A
K
D
-------
P
E
-
R
A
A
R
R
L
-
V
--
H
I
-
P
-
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
Y
V
T
P
L
23
PsiBlast_CBE
97.66
85%
-95
- C1 -
4WEC
5
?
B:
[25-278]
----
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
---
G
D
I
----
D
---
P
T
-
T
--------
G
K
A
A
-
A
D
E
L
-----
E
-----
G
-----
L
----
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
-
P
P
E
D
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
--
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
----
L
Q
E
----
L
F
A
K
D
-------
P
E
-
R
A
A
R
R
L
-
V
--
H
I
-
P
-
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
Y
V
T
P
L
111
HHSearch
96.87
85%
-95
- C1 -
4WEC
5
?
A:
[25-278]
----
T
Q
R
L
A
G
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
---
G
D
I
----
D
---
P
T
-
T
--------
G
K
A
A
-
A
D
E
L
-----
E
-----
G
-----
L
----
F
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
S
-
P
P
E
D
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
V
P
A
-
G
-
K
G
-
S
I
I
N
T
A
S
F
V
A
V
M
G
S
A
T
S
Q
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
--
G
I
R
V
N
A
L
C
P
G
P
V
N
T
P
L
----
L
Q
E
----
L
F
A
K
D
-------
P
E
-
R
A
A
R
R
L
-
V
--
H
I
-
P
-
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
I
S
S
A
Y
V
T
P
L
15
PsiBlast_PDB
79.20
39%
-104
- C1 -
2ZTV
2
?
A:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
A
E
I
E
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
Q
I
S
A
L
A
E
K
N
GVD----
Q
E
-
T
A
A
R
E
L
-
L
S
E
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
52
PsiBlast_CBE
78.67
34%
-90
- C1 -
1RWB
1
DHG_BACME
E:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
KVGGE
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
K
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
77
PsiBlast_CBE
78.64
34%
-90
- C1 -
1GCO
1
DHG_BACME
F:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
KVGGE
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
3
PsiBlast_PDB
78.64
39%
-101
- C1 -
4NBU
1
?
A:
[10-248]
------
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
---
A
D
F
----
N
---
E
A
-
A
--------
G
K
E
A
-
V
E
A
N
-----
P
-----
G
V
----
V
----
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
---
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
-
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
A
E
----
V
-----------
P
E
-
K
V
I
E
K
M
K
A
--
Q
V
-
P
-
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
--------
25
PsiBlast_CBE
78.56
39%
-101
- C1 -
4NBU
1
?
C:
[10-248]
------
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
---
A
D
F
----
N
---
E
A
-
A
--------
G
K
E
A
-
V
E
A
N
-----
P
-----
G
V----
V
----
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
---
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
-
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
A
E
----
V
-----------
P
E
-
K
V
I
E
K
M
K
A
--
Q
V
-
P
-
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
--------
82
PsiBlast_CBE
78.49
34%
-90
- C1 -
1GEE
1
DHG_BACME
E:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
KVGGE
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
92
PsiBlast_CBE
78.31
39%
-101
- C1 -
2ZTM
2
?
A:
[6-259]
-----------
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
A
E
I
E
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
S
P
L
----
V
E
K
Q
I
S
A
L
A
E
K
N
GVD----
Q
E
-
T
A
A
R
E
L
-
L
S
E
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
78
PsiBlast_CBE
78.22
34%
-90
- C1 -
1GCO
1
DHG_BACME
E:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
KVGGE
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
30
PsiBlast_CBE
78.22
40%
-93
- C1 -
1IY8
2
LVR_LEIAQ
E:
[10-267]
------
R
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
---
V
D
V
----
S
SEG
L
E
-
A
--------
S
K
A
A
-
V
L
E
T
-----
A
-----
P
DAEV-
L
----
T
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
E
-
G
K
Q
-
N
P
T
E
S
F
T
A
A
E
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
-
S
G
-
M
V
V
N
T
A
S
V
G
G
I
R
G
I
G
-
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
--
G
I
R
I
N
A
I
A
P
G
A
I
W
T
P
M
VENS
M
K
Q
----
L
D
P
E
N
-------
P
R
-
K
A
A
E
E
F
-
I
--
Q
V
N
P
-
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
Y
----
80
PsiBlast_CBE
78.21
34%
-89
- C1 -
1GCO
1
DHG_BACME
A:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
K
V
G
G
E
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
84
PsiBlast_CBE
78.17
34%
-89
- C1 -
1GEE
1
DHG_BACME
A:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
K
V
G
G
E
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
14
PsiBlast_PDB
78.14
39%
-102
- C1 -
2ZTL
2
?
A:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
A
E
I
E
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
Q
I
S
A
L
A
E
K
N
GVD----
Q
E
-
T
A
A
R
E
L
-
L
S
E
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
57
PsiBlast_CBE
78.13
39%
-103
- C1 -
2ZTL
3
?
D:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
NGF
G
D
A
AEIE
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
QISA
L
A
E
K
N
GVD----
Q
E
-
T
A
A
R
E
L
-
L
SE
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
4
PsiBlast_PDB
78.10
40%
-93
- C1 -
1IY8
2
LVR_LEIAQ
A:
[10-267]
------
R
F
T
D
R
V
V
L
I
T
G
G
G
S
G
L
G
R
A
T
A
V
R
L
A
A
E
G
A
K
L
S
L
---
V
D
V
----
S
S
E
G
L
E
-
A
--------
S
K
A
A
-
V
L
E
T
-----
A
-----
P
D
A
E
V
-
L
----
T
T
V
A
D
V
S
D
E
A
Q
V
E
A
Y
V
T
A
T
T
E
R
F
G
R
I
D
G
F
F
N
N
A
G
I
E
-
G
K
Q
-
N
P
T
E
S
F
T
A
A
E
F
D
K
V
V
S
I
N
L
R
G
V
F
L
G
L
E
K
V
L
K
I
M
R
E
Q
-
G
-
S
G
-
M
V
V
N
T
A
S
V
G
G
I
R
G
I
G
-
N
Q
S
G
Y
A
A
A
K
H
G
V
V
G
L
T
R
N
S
A
V
E
Y
G
R
Y
--
G
I
R
I
N
A
I
A
P
G
A
I
W
T
P
M
V
E
N
S
M
K
Q
----
L
D
P
E
N
-------
P
R
-
K
A
A
E
E
F
-
I
--
Q
V
N
P
-
S
K
R
Y
G
E
A
P
E
I
A
A
V
V
A
F
L
L
S
D
D
A
S
Y
V
N
A
T
V
V
P
I
D
G
G
Q
S
A
A
Y
----
81
PsiBlast_CBE
77.99
34%
-89
- C1 -
1GEE
1
DHG_BACME
F:
[1-251]
---
M
Y
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
---
N
Y
R
----
S
---
K
E
D
E
--------
A
N
S
V
-
L
E
E
I
-----
K
KVGGE
A
-----
I
----
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
-
N
P
V
S
S
--
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
--
G
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
----
N
A
E
----
K
F
A
-
D
-------
P
E
-
Q
R
A
D
V
E
-
S
--
M
I
-
P
-
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
-------
58
PsiBlast_CBE
77.89
39%
-102
- C1 -
2ZTL
2
?
C:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
NGF
G
D
A
AEIE
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
QISA
L
A
E
K
N
GVD----
Q
E
-
T
A
A
R
E
L
-
L
SE
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
24
PsiBlast_CBE
77.87
39%
-99
- C1 -
4NBU
2
?
D:
[10-248]
------
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
---
A
D
F
----
N
---
E
A
-
A
--------
G
K
E
A
-
V
E
A
N
-----
P
-----
G
V----
V
----
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
---
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
-
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
A
E
----
V
-----------
P
E
-
K
V
I
E
K
M
K
A
--
Q
V
-
P
-
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
--------
55
PsiBlast_CBE
77.55
39%
-99
- C1 -
2ZTV
2
?
C:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
A
E
I
E
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
Q
I
S
A-----GVD----
Q
E
-
T
A
A
R
E
L
-
L
SE
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
116
HHSearch
77.45
37%
-88
- C1 -
3WDS
4
?
A:
[7-261]
----
I
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
---
A
D
L
----
D
---
V
M
-
A
--------
A
Q
A
V
-
V
A
G
L
EN---
G
-----
G
-----
F
----
A
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
G
V
S
-
T
--
M
R
P
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
-
K
G
-
V
I
V
N
T
A
S
L
A
A
K
V
G
A
-
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
P
K
--
N
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
----
Q
E
R
----
E
I
I
W
E
A
E
L
R
GMT
P
E
A
V
R
A
E
Y
V
-
S
--
L
T
-
P
-
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
V
R
-------
26
PsiBlast_CBE
76.84
39%
-99
- C1 -
4NBU
2
?
B:
[10-248]
------
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
---
A
D
F
----
N
---
E
A
-
A
--------
G
K
E
A
-
V
E
A
N
-----
P
-----
G
V
----
V
----
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
---
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
-
G
-
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
-
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
----
V
A
E
----
V
-----------
P
E
-
K
V
I
E
K
M
K
A
--
Q
V
-
P
-
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
--------
54
PsiBlast_CBE
76.54
39%
-101
- C1 -
2ZTV
3
?
D:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
NGF
G
D
A
AEIE
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
QIS------VD-----
Q
E
-
T
A
A
R
E
L
-
L
SE
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
19
PsiBlast_PDB
76.21
34%
-84
- C1 -
4RF2
1
?
A:
[23-271]
-----
D
R
L
K
G
K
V
A
I
V
T
G
G
T
L
G
I
G
L
A
I
A
D
K
F
V
E
E
G
A
K
V
V
I
---
T
G
R
----
H
---
A
D
-
V
--------
G
E
K
A
-
A
K
S
I
-----
G
-----
G
-----
T
DV
I
R
F
V
Q
H
D
A
S
D
E
A
G
W
T
K
L
F
D
T
T
E
E
A
F
G
P
V
T
T
V
V
N
N
A
G
I
A
-
V
S
K
S
--
V
E
D
T
T
T
E
E
W
R
K
L
L
S
V
N
L
D
G
V
F
F
G
T
R
L
G
I
Q
R
M
K
N
K
-
G
-
L
G
A
S
I
I
N
M
S
S
I
E
G
F
V
G
D
P
T
L
G
-
A
Y
N
A
S
K
G
A
V
R
I
M
S
K
S
A
A
L
D
C
A
L
K
DY
D
V
R
V
N
T
V
H
P
G
Y
I
K
T
P
L
----
V
D
D
----
L
--
E
G
-------
A
E
-
E
M
M
S
Q
R
-
T
--
K
T
-
P
-
M
G
H
I
G
E
P
N
D
I
A
W
I
C
V
Y
L
A
S
D
E
S
K
F
A
T
G
A
E
F
V
V
D
G
G
Y
T
A
------
63
PsiBlast_CBE
75.51
35%
-99
- C1 -
2CFC
2
HCDR_XANP2
B:
[3-249]
----------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
---
L
D
L
----
S
---
A
E
-
T
LEETARTH
W
H
A
Y
-
A
D
K
V
-----------------
L
----
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
N
S
E
A
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
-
A
G
-
V
I
V
N
I
A
S
-
V
A
S
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
--
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
----
T
Q
W
----
R
L
-
D
Q
-------
P
E
-
L
R
D
Q
V
L
-
A
--
R
I
-
P
-
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
------
56
PsiBlast_CBE
74.22
39%
-104
- C1 -
2ZTV
2
?
B:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
A
E
I
E
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
----
V
E
K
-------------------
T
A
A
R
E
L
-
L
SE
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
62
PsiBlast_CBE
74.15
35%
-100
- C1 -
2CFC
2
HCDR_XANP2
C:
[3-249]
----------
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
---
L
D
L
----
S
---
A
E
-
T
LEETARTH
W
H
A
Y
-
A
D
K
V
-----------------
L
----
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
N
S
E
A
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
-
A
G
-
V
I
V
N
I
A
S
-
V
A
S
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
--
G
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
----
T
Q
W
----
R
L
-
D
Q
-------
P
E
-
L
R
D
Q
V
L
-
A
--
R
I
-
P
-
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
------
68
PsiBlast_CBE
73.76
36%
-91
- C1 -
4URF
9
?
A:
[3-244]
-------
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
---
S
D
I
----
S
---
D
E
-
W
--------
G
R
E
T
-
L
A
L
I
-----
E
-----
G
K
G
G
K
A
V
----
F
Q
H
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
-
G
E
F
T
P
T
A
E
T
T
D
-
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
-
G
-
G
G
-
A
I
V
N
I
S
S
I
A
G
Q
I
G
-
I
E
G
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
--
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
----
V
Q
N
----
V
-----------
P
L
-
E
T
R
R
Q
L
-
E
--
Q
M
-
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
---------
72
PsiBlast_CBE
73.58
34%
-92
- C1 -
4I08
6
FABG_VIBCH
A:
[10-248]
-------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
-
V
I
---
G
T
A
----
T
---
S
E
-
S
--------
G
A
Q
A
I
S
D
Y
L
GD---
N
-----
G
-----
K
----
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
---
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
-
Q
G
-
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
-
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
--
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---------------
N
-------
D
E
-
Q
R
T
A
T
L
-
A
--
Q
V
-
P
-
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
--------
13
PsiBlast_PDB
72.30
39%
-101
- C1 -
1X1T
3
?
A:
[2-259]
-------
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
A
E
I
E
K
---
V
R
-
A
--------
G
L
A
A
-
Q
H
G
V
-----
K
-----
V
-----
L
----
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
---
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
-
G
-
F
G
-
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
--
G
I
T
A
N
A
I
C
P
G
W
V
R
T
---------------------------------
L
-
L
SE
K
Q
-
P
-
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
------
69
PsiBlast_CBE
72.29
36%
-93
- C1 -
4URE
5
?
B:
[3-244]
-------
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
---
S
D
I
----
S
---
D
E
-
W
--------
G
R
E
T
-
L
A
L
I
-----
E
-----
G
KGGKA
V
----
F
Q
H
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
-
G
E
F
T
P
T
A
E
T
T
D
-
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
-
G
-
G
G
-
A
I
V
N
I
S
S
I
A
G
Q
I
G
-
I
E
G
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
--
G
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
----
V
Q
N
----
V
-----------
P
L
-
E
T
R
R
Q
L
-
E
--
Q
M
-
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
---------
118
HHSearch
71.67
33%
-72
- C1 -
4FN4
3
?
A:
[2-252]
----
Y
Q
S
L
K
N
K
V
V
I
V
T
G
A
G
S
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
V
A
---
V
E
L
----
L
---
E
D
-
R
--------
L
N
Q
I
-
V
Q
E
L
R
G
M
G
K
E
-----
V
-----
L
----
G
V
K
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
-
D
G
-
V
T
P
V
A
E
V
S
D
E
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
S
R
A
V
I
P
I
M
L
K
Q
-
G
-
K
G
-
V
I
V
N
T
A
S
I
A
G
I
R
G
G
-
F
A
G
A
P
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
--
G
I
R
A
V
A
V
L
P
G
T
V
K
T
N
I
----
G
L
G
----
S
S
K
P
S
-------
E
L
G
M
R
T
L
T
K
-
L
--
M
S
-
L
-
S
S
R
L
A
E
P
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
-------