@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2967c: (2016-05-15 )
MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRLKADESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLAAACAAAGISFVGPSAEVLELAGNKSRAIAAAREAGLPVLMSSAPSASVDELLSVAAGMPFPLFVKAVAGGGGRGMRRVGDIAALPEAIEAASREAESAFGDPTVYLEQAVINPRHIEVQILADNLGDVIHLYERDCSVQRRHQKVIELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDERGEYVFIEMNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAALQCRITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSMLVKLTCRGRDLPTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGRVTTSFIDERPQLLTARASADRGTKILNFLADVTVNNPYGSRPSTIYPDDKLPDLDLRAAPPAGSKQRLVKLGPEGFARWLRESAAVGVTDTTFRDAHQSLLATRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERLATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIFRIFDALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPGGQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLSLSAVCALEPYWEALRKVYAPFESGLPGPTGRVYHHEIPGGQLSNLRQQAIALGLGDRFEEIEEAYAGADRVLGRLVKVTPTSKVVGDLALALVGAGVSADEFASDPARFGIPESVLGFLRGELGDPPGGWPEPLRTAALAGRGAARPTAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNEHREAYGDTSQLSANQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCILNGQLRPVLVRDRSIASAVPAAEKADRGNPGHIAAPFAGVVTVGVCVGERVGAGQTIATIEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS
Atome Classification :
(67 SA)
.........10........20........30........40........50.-....---...60........70........80........90........100.......110.......120.......130.-...-.-.-.---.140--.--......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.-------......260.......270.......-280-........290.......300.......310.......320-...--.---.--...330.......340.......350.......360.......370-...-....380.......390.......400.......410.......420.......430.......440.......450.......460.......470..--...--..480-........490..-.....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670....-.-..680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930-.--....--...940.......950-----....-------..-------...960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060.....-.1070........1080......1090......1100......1110......1120....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
S
K
V
L
VANRG
E
I
A
I
R
A
F
R
A
A
Y
ELGV
G
T
V
A
V
Y
PYEDRNSQHRLKADESYQIG-DIGH---
P
V
H
A
Y
L
S
V
D
E
I
V
A
T
A
R
RAGADAIYPGYGFLSENP
D
L
A
A
A
C
A
AAGISFVGP
S
A
E
V
L
E
LAGNKS
R
A
I
A
A
A
R
EAGL
P
V
-
L
-MSS-A-P-S---A
S
V
D
--
E
--
L
L
S
V
AAGMP
F
P
L
F
V
K
A
VAGGGGRG
M
R
RV
G
D
I
A
A
L
P
E
A
I
E
A
A
S
R
E
A
E
SAFGDP
T
V
Y
L
E
Q
AVINP
R
H
I
E
V
Q
I
L
A
DNL
G
D
V
I
H
L
Y
ERDC
S
V
Q
R
R
H
Q
K
V
I
ELAPAPHL
D
A
E
L
R
Y
-------
K
M
C
V
D
A
V
A
F
A
R
H
IGYS
C
A
G
T
V
E
F
L
L
D-E-R-G
E
Y
V
F
I
EMNP
R
V
Q
V
E
H
TVTEEI
T
D
V
D
L
V
A
S
Q
L
R
IAA
G
E
T
L
--
E
Q
L--G---L--RQEDIAPHG
A
A
L
Q
C
R
I
TTEDPANGFRPDTGRI
S
A
L
RTAGGA
G
V
R
LD-GST-NLGAE
I
S
P
Y
F
D
S
M
L
V
K
L
T
CRGRDL
P
T
A
V
S
R
A
R
R
A
I
A
E
F
R
I
RGVSTN
I
P
F
L
Q
A
V
LDDPDFRAG
R
V
T
T
S
F
I
DERP
Q
L
L
T
ARASADR
G
T
K
I
L
N
F
L
A
D
V
T
VNN--PYG--SRPS--TIYPDDKLPDLDL-RAAPPAGS
K
Q
R
L
V
KL
G
P
E
G
F
A
R
W
L
R
E
SAAVGVTD
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
TS
G
L
S
R
V
A
P
Y
L
A
R
T
M
P
Q
L
L
S
V
E
CWGG
A
T
Y
D
V
A
L
R
F
L
KED
P
W
E
R
L
A
T
L
R
A
A
M
P
N
I
C
L
Q
M
L
LRGRNTVGYTP
Y
P
E
I
V
T
S
A
F
V
Q
E
ATATG
I
D
I
F
R
I
F
D
A
L
N
N
I
E
S
M
R
P
A
I
D
A
V
R
E
T
G
S
A
I
A
E
V
A
M
CYTGDLTDPG-E-
Q
L
Y
T
L
D
Y
Y
L
K
L
A
E
Q
I
V
D
AGA
H
V
L
A
I
K
D
M
A
G
LLRP
P
A
A
Q
R
L
V
S
A
L
R
SRFDL
P
V
H
L
HTHDTP
G
G
Q
L
A
S
Y
V
A
A
W
HAGADAVDGAAAPLAGTTS
Q
P
A
L
S
S
I
V
A
A
A
AHTEYDTGLS
L
S
A
V
CAL
E
P
Y
W
E
A
L
R
K
V
Y
A
P
F
ESGLPGPTG
R
V
Y
H
H
EIPG
G
Q
L
S
N
L
R
Q
Q
A
I
ALGL
G
D
R
F
E
E
I
E
E
A
YA
G
A
D
R
V
L
G
R
L
VKVTP
T
S
K
V
V
G
D
L
A
L
A
L
VGAGV
S
A
D
E
FAS
D
P
ARFGI
P
E
S
V
L
G
F
L
R
G
ELGDPPGG
W
P
E
P
L
R
T
A
A
LAGRG--A--ARPT--AQLAADD
E
I
A
L
S
SV-------G
A
K
R
-------
Q
A
-------
T
L
N
RLLFPS
P
T
K
E
F
N
E
H
R
E
AYGDTSQL
S
A
N
Q
F
F
Y
GLRQGE
E
H
R
V
K
L
E
RGV
E
L
L
I
G
L
E
AISEPDERG
M
R
T
V
M
C
I
LNGQL
R
P
V
L
V
RDR
S
I
A
SAVPAAEKADRGNPGHIAAP
F
A
G
-
V
V
-
T
-
V
G
V
C
VGERVGAG
Q
T
I
A
T
I
E
A
M
KMEAPITAPVAG
T
V
E
R
V
AVSD
T
A
QVEGG
D
L
L
V
V
VS
30
PsiBlast_CBE
82.92
46%
-91
- C1 -
3HB9
3
?
D:
[5-1113]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P--------------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
S
---
G
-
D
E
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
-
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
FP
N
V
E
--
K
R
P
K
--
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
T
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
-
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
S
-
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVTEQD
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
--------------------------------------------------
A
M
K
M
---------------------------------
25
PsiBlast_CBE
82.72
46%
-90
- C1 -
3HO8
4
?
C:
[5-1061]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
--------------------------------------------------------------------------
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
S
---
G
-
D
E
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
-
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
FP
N
V
E
--
K
R
P
K
--
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
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R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
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N
V
L
F
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M
L
L
R
A
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N
A
V
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Y
K
N
Y
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D
N
V
I
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K
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A
K
A
G
I
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I
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D
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L
N
W
V
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Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
-
I
S
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G
T
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C
Y
T
G
D
I
L
N
P
E
R
S
-
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
L
T
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVT
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.30
46%
-90
- C1 -
3HO8
4
?
B:
[5-1061]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P--------------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
S
---
G
-
D
E
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
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M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
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A
D
L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
D
I
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T
L
G
Y
A
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C
R
I
T
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P
D
T
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G
F
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L
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N
V
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N
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FP
N
V
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--
K
R
P
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--
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Y
E
L
A
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S
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T
K
Q
L
L
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E
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G
P
K
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V
K
K
Q
D
D
V
L
L
T
D
T
T
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A
H
Q
S
L
L
A
T
R
V
R
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D
M
I
N
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A
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T
A
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D
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W
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L
K
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L
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A
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S
-
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L
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E
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F
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L
A
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K
D
M
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L
L
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K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
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N
G
L
L
T
Y
K
Q
A
I
D
A
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V
D
I
I
D
T
A
V
A
S
M
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L
T
S
Q
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S
A
N
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L
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Y
A
L
N
G
F
P
R
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L
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M
E
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Y
W
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Y
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D
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I
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Q
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M
P
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Q
Y
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N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
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V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
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S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
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I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
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M
R
N
G
E
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V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
21
PsiBlast_CBE
81.21
46%
-90
- C1 -
4HNT
2
?
D:
[28-1084]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
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Q
F
A
R
R
C
A
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G
I
K
F
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G
P
H
L
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L
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M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P--------------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
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Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
S
---
G
-
D
E
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
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L
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D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
A
G
V
R
L
D
A
G
D
G
-
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
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E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
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N
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F
L
I
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K
N
K
K
F
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D
Y
T
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K
F
I
E
E
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P
E
L
F
D
I
Q
P
S
L
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T
K
T
L
E
Y
I
G
N
V
T
I
N
G
FP
N
V
E
--
K
R
P
K
--
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
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Y
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N
Y
P
D
N
V
I
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K
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A
K
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F
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I
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D
S
L
N
W
V
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Q
M
K
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E
A
V
Q
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K
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T
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L
N
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-
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I
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Y
Y
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L
A
K
E
L
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E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
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D
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E
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M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVTEQD
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
23
PsiBlast_CBE
81.01
46%
-90
- C1 -
4HNT
2
?
B:
[28-1084]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
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D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
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R
C
A
E
E
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G
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L
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F
G
D
K
V
K
A
R
T
T
A
I
K
A
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L
P
V
-
I
P--------------------------------------------------------------------------------
I
D
N
P
K
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V
Q
V
I
G
D
E
H
G
N
I
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H
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C
S
V
Q
R
R
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Q
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Q
-------
R
I
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---
G
-
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I
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T
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A
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A
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L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
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A
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Q
C
R
I
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T
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P
L
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M
P
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T
I
I
A
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S
G
G
A
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V
R
L
D
A
G
D
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-
F
Q
G
A
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I
S
P
Y
Y
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L
L
V
K
L
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T
H
A
I
S
F
K
Q
A
E
E
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R
S
L
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I
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T
N
I
P
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M
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N
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K
F
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P
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FP
N
V
E
--
K
R
P
K
--
P
D
Y
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K
I
A
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T
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V
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K
Q
D
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V
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K
D
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L
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M
W
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F
D
V
A
Y
N
F
L
K
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P
W
E
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L
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L
R
K
A
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N
V
L
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L
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A
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Y
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N
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A
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A
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A
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K
-
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S
-
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K
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E
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A
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L
L
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K
A
A
Y
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L
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A
V
D
L
P
I
H
L
H
T
H
D
T
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G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
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L
Y
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M
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Y
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N
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G
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Y
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Q
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L
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F
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E
V
K
D
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Y
R
R
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N
F
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I
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M
A
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F
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Q
P
V
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L
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A
V
I
L
K
G
Q
E
--
A
L
T
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVT
E
Q
D
I
I
S
Y
V
L
Y
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K
V
Y
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Y
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T
R
N
Q
Y
G
N
L
S
L
L
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T
P
T
F
F
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M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
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K
L
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D
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N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.74
46%
-89
- C1 -
4HNU
2
?
D:
[28-1084]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
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R
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D
V
A
K
Q
A
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V
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A
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P
G
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F
L
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F
A
R
R
C
A
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E
G
I
K
F
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G
P
H
L
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L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P--------------------------------------------------------------------------------
I
D
N
P
K
H
I
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V
Q
V
I
G
D
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H
G
N
I
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H
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F
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V
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S
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L
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Q
-------
R
I
C
D
A
A
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L
M
E
N
I
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N
A
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F
L
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---
G
-
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A
D
L
FG
E
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--
N
---
M
P-
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Q
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L
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Y
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C
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I
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D
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M
P
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T
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L
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V
T
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FP
N
V
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--
K
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K
--
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L
L
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P
K
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K
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D
D
V
L
L
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L
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A
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D
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L
L
K
P
K
A
A
Y
E
L
I
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L
K
S
A
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D
L
P
I
H
L
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N
G
L
L
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Y
K
Q
A
I
D
A
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D
I
I
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M
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L
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F
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D
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Y
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F
L
F
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I
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V
V
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M
A
L
Y
M
V
Q
N
D
L
D
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I
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Y
K
L
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V
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D
L
Q
A
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I
L
K
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Q
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--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
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F
E
K
V
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L
-------
L
E
E
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-------
Q
Q
GPVTEQD
I
I
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Y
V
L
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P
K
V
Y
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T
R
N
Q
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N
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M
R
N
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V
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K
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K
R
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K
L
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I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.34
46%
-88
- C1 -
3HO8
3
?
A:
[5-1061]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
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T
V
A
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Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
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E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
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E
R
I
I
D
V
A
K
Q
A
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V
D
A
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L
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A
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M
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K
V
K
A
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T
A
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K
A
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P
V
-
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P
G
T
D
---------------------------------------------------------------------------
R
Y
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P
K
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G
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V
V
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S
V
G
L
S
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T
L
R
Q
-------
R
I
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D
A
A
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M
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Y
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N
A
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L
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---
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-
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A
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--
N
---
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F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVT
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
35
PsiBlast_CBE
80.22
46%
-90
- C1 -
4HNU
1
?
B:
[28-1084]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P--------------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
S
---
G
-
D
E
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
-
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
E
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
FP
N
V
E
--
K
R
P
K
--
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
-
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
S
-
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVT
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.88
46%
-91
- C1 -
3BG5
5
?
A:
[28-1168]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
-
G
-
P
-
I
---
K
S
Y
E
--
L
--
A
K
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
-------
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
S
F
G
N
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
S
---
G
-
D
E
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
FG
E
E
I
--
N
---
M
P-
Q
Q
K
D
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
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D
T
G
T
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I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
-
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
FP
N
V
E
--
K
R
P
K
--
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
-
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
S
-
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVT
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
-
S
V
-
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
-
7
PsiBlast_PDB
77.17
46%
-91
- C1 -
4HNV
5
?
A:
[28-1168]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
E
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
----
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
-
G
-
P
-
I
---
K
S
Y
E
--
L
--
A
K
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
-------
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
----
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
-------
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
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---
G
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A
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E
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--
N
---
M
P-
Q
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LT
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--
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-------
L
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-------
Q
Q
GPVT
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N
N
G
D
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D
L
L
I
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I
-
6
PsiBlast_PDB
77.05
46%
-90
- C1 -
3HBL
3
?
A:
[5-1145]
--
K
K
L
L
V
A
N
R
G
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A
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----
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---
K
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--
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--
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M
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A
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Y
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---
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--
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---
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N
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--
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LT
A
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--
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L
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L
-------
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-------
Q
Q
GPVT
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Y
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K
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Y
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N
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L
L
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Q
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V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
-
27
PsiBlast_CBE
76.85
46%
-94
- C1 -
3BG5
4
?
D:
[28-1168]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
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L
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N
E
D
K
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K
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L
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G
----
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A
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A
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P
V
-
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P--------------------------------------------------------------------------------
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P
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N
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V
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L
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-------
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---
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-
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--
N
---
M
P-
Q
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L
I
G
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K
S
A
V
D
L
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H
L
H
T
H
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T
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G
N
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T
Y
K
Q
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D
A
G
V
D
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T
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M
S
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L
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P
S
A
N
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L
Y
Y
A
L
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G
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P
R
H
L
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D
I
E
G
M
E
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L
S
H
Y
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S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
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N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
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M
A
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Y
M
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Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
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S
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V
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F
F
K
G
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I
G
Q
P
V
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G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
--
A
LT
A
R
P
G
--
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
-------
L
E
E
E
-------
Q
Q
GPVTEQD
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
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Q
Y
G
N
L
S
L
L
D
T
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T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
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Q
A
R
R
I
Y
I
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D
E
N
-------
K
P
K
A
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K
S
N
P
S
H
I
G
A
Q
M
P
G
-
S
V
-
T
E
V
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V
G
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K
A
N
Q
P
L
L
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E
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M
K
M
E
T
T
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F
D
G
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K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
-
36
PsiBlast_CBE
76.73
46%
-93
- C1 -
3HBL
3
?
D:
[5-1145]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
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S
Y
L
V
G
S
D
L
G
----
P
A
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S
Y
L
N
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G
P
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M
F
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K
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K
A
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T
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A
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K
A
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V
-
I
P--------------------------------------------------------------------------------
I
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N
P
K
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-------
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---
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-
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--
N
---
M
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G
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L
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F
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--
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--
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-------
L
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E
-------
Q
Q
GPVTEQD
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
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N
L
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L
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M
R
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G
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V
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E
I
D
K
G
K
R
L
I
I
K
L
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S
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E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
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N
-------
K
P
K
A
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K
S
N
P
S
H
I
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A
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M
P
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-
S
V
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M
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Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
-
29
PsiBlast_CBE
76.71
46%
-93
- C1 -
3BG5
4
?
B:
[28-1168]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
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L
D
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N
E
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G
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L
G
----
P
A
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Y
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D
V
A
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Q
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F
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K
V
K
A
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T
T
A
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K
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P
V
-
I
P--------------------------------------------------------------------------------
I
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P
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-------
R
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---
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-
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--
N
---
M
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--
A
LT
A
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--
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Y
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-------
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-------
Q
Q
GPVT
E
Q
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L
Y
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K
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Y
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N
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L
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E
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V
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E
I
D
K
G
K
R
L
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L
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N
G
N
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T
I
Y
Y
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A
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A
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N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
-
4
PsiBlast_PDB
76.68
46%
-89
- C1 -
3HB9
4
?
A:
[5-1145]
--
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
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L
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A
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N
E
D
K
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K
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L
V
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L
G
----
P
A
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GPVT
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L
L
I
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I
-
39
PsiBlast_CBE
76.40
46%
-93
- C1 -
4HNV
4
?
D:
[28-1168]
--
K
K
L
L
V
A
N
R
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----
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GPVT
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-------
K
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D
L
L
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E
I
-
44
PsiBlast_CBE
76.32
46%
-90
- C1 -
4QSH
4
?
B:
[7-1146]
--
K
K
V
L
V
A
N
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V
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I
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L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
-
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
-
R
-
T
K
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
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K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
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G
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L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
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Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
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F
F
M
G
E
I
G
Q
P
Y
G
G
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K
L
Q
K
L
V
L
K
G
R
T
P
L
T
--
D
R
P
G
--
A
L
M
E
P
V
N
F
V
E
V
K
A
E
-------
L
K
E
K
M
GYEPT
E
K
D
-------
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
-
Q
-
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
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T
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A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
N
119
HHSearch
76.31
46%
-90
- C1 -
4QSH
4
?
A:
[5-1146]
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
-
A
G
K
K
---
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
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Y
G
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L
S
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L
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M
F
G
D
K
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A
K
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Q
A
L
L
A
D
I
P
V
-
I
---------------------------------------------------------------------------------
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
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R
R
H
Q
K
V
V
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V
A
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A
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T
S
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L
R
N
-------
R
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A
A
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K
L
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-
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---
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A
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--
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--
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V
T
V
N
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--
F
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--
I
K
H
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DK
P
V
Y
A
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R
L
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-
G
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K
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L
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L
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M
L
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L
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-
K
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H
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A
A
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R
L
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A
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D
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Y
G
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Q
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I
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L
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Y
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P
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Y
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L
Q
Q
Q
A
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A
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L
G
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D
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K
E
M
Y
T
V
V
N
Q
M
F
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S
K
V
V
G
D
L
A
L
F
M
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L
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D
V
Y
E
K
G
D
T
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D
F
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D
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V
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M
G
E
I
G
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P
Y
G
G
F
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L
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K
L
V
L
K
G
R
T
--
P
--
L
T
D
R
PG
A
L
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N
F
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K
A
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L
K
E
K
M
GY
E
P
T
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-------
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D
-------
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
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M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
-
S
V
I
Q
-
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
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T
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A
M
K
M
E
T
T
I
Q
A
P
F
D
G
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V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
N
118
HHSearch
76.31
46%
-89
- C1 -
3HBL
3
?
A:
[3-1146]
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
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L
D
I
S
T
V
A
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Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
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S
Y
L
V
G
-
S
D
L
G
---
P
A
E
S
Y
L
N
I
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R
I
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D
V
A
K
Q
A
N
V
D
A
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H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
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G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
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T
A
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K
A
D
L
P
V
-
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-
P
G
T
-
D
G
P
-
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---
K
S
Y
E
--
L
--
A
K
E
F
A
E
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A
G
F
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L
M
I
K
A
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S
-------
R
I
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R
E
E
S
E
L
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A
F
H
R
A
K
S
E
A
E
------
E
V
Y
I
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Y
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K
H
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V
Q
V
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G
D
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R
R
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Q
K
V
V
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A
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L
S
P
T
L
R
Q
-------
R
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C
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A
A
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I
K
Y
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K
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--
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N
---
M
P-
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E
--
A
--
L
T
A
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PG
E
Y
L
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P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
QG
P
V
T
E
-------
Q
D
-------
I
I
S
Y
V
L
Y
P
K
V
Y
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Q
Y
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R
N
Q
Y
G
N
L
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L
L
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F
F
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M
R
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G
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V
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I
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I
D
K
G
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A
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A
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R
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T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
-
S
V
T
E
-
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
E
8
PsiBlast_PDB
76.28
46%
-89
- C1 -
4QSK
3
?
A:
[6-1145]
--
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
-
A
G
K
K
---
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
-
I
P-------------------------------------------------------------------------------
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
-------
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
-
G
-
D
D
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
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M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
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Y
A
L
H-
D
Q
L
--
V
---
A
IP
K
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I
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G
S
A
I
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I
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N
F
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R
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T
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A
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G
-
F
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V
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Y
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L
L
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L
C
T
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M
T
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E
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A
T
R
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M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
G
T
K
T
L
R
Y
I
G
N
V
T
V
N
G
--
F
P
G
IK
H
R
D
K
--
P
V
Y
A
E
P
R
L
P
K
I
P
Y
-
G
S
Q
I
S
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
K
D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
-
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
-
R
-
T
K
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
--
D
R
P
G
--
A
L
M
E
P
V
N
F
V
E
V
K
A
E
-------
L
K
E
K
M
GYEPT
E
K
D
-------
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
-
Q
-
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
N
15
PsiBlast_PDB
54.13
45%
-89
- C1 -
4MV3
3
ACCC_HAEIN
A:
[21-463]
M
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
-
P
-
A
P
---
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
-
V
-
P
G
S
-
D
-
G
-
P
---
V
S
N
D
I
A
K
--
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
------
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
-------
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
-----
I
--
S
---
F
--
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
-
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
53.74
44%
-85
- C1 -
2W71
2
ACCC_ECOLI
C:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
53.71
44%
-83
- C1 -
2W70
2
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
53.67
44%
-83
- C1 -
3G8D
3
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
A
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
53.63
44%
-82
- C1 -
3JZF
1
ACCC_ECOLI
B:
[22-464]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
53.59
44%
-83
- C1 -
2W6Z
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
53.58
44%
-85
- C1 -
2W6M
2
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.52
45%
-89
- C1 -
4RZQ
2
ACCC_HAEIN
A:
[21-463]
M
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
-
P
-
A
P
---
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
-
V
-
P
G
S
-
D
-
G
-
P
-------A-
K
--
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
----------
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
----------
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
-------
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
-----
I
--
S
---
F
--
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
-
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
53.40
44%
-82
- C1 -
2W6P
1
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
53.35
44%
-82
- C1 -
3JZI
1
ACCC_ECOLI
B:
[22-464]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
53.23
44%
-83
- C1 -
3RV4
10
ACCC_ECOLI
A:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
E
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
53.18
44%
-83
- C1 -
2W71
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
53.16
44%
-85
- C1 -
2VR1
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
--
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
53.15
44%
-83
- C1 -
3G8C
4
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
52.93
40%
-80
- C1 -
3OUZ
15
?
A:
[5-446]
E
I
K
S
I
L
I
A
N
R
G
E
I
A
L
R
A
L
R
T
I
K
E
M
G
K
K
A
I
C
V
Y
S
E
A
D
K
D
A
L
Y
L
K
Y
A
D
A
S
I
C
I
G
-
K
A
R
S
----
S
E
S
Y
L
N
I
P
A
I
I
A
A
A
E
I
A
E
A
D
A
I
F
P
G
Y
G
F
L
S
E
N
Q
N
F
V
E
I
C
A
K
H
N
I
K
F
I
G
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
Q
R
A
G
V
P
V
-
I
-
P
G
S
-
D
G
A
-
L
---
A
G
A
E
--
A
--
A
K
K
L
A
K
E
I
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
E
N
E
K
D
L
E
K
A
Y
W
S
A
E
S
E
A
M
T
A
F
G
D
G
T
M
Y
M
E
K
Y
I
Q
N
P
R
H
I
E
V
Q
V
I
G
D
S
F
G
N
V
I
H
V
G
E
R
D
C
S
M
Q
R
R
H
Q
K
L
I
E
E
S
P
A
I
L
L
D
E
K
T
R
T
-------
R
L
H
E
T
A
I
K
A
A
K
A
I
G
Y
E
G
A
G
T
F
E
F
L
V
D
-
K
-
N
-
L
D
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
V
S
E
M
V
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
Y
A
L
--
P
S
Q
--
E
---------
S
I
K
L
N
G
H
S
I
E
C
R
I
T
A
E
D
S
K
-
T
F
L
P
S
P
G
K
I
T
K
Y
I
P
P
A
G
R
N
V
R
M
E
-
S
H
C
-
Y
Q
D
Y
S
V
P
A
Y
Y
D
S
M
I
G
K
L
V
V
W
A
E
D
R
N
K
A
I
A
K
M
K
V
A
L
D
E
L
L
I
S
G
I
K
T
T
K
D
F
H
L
S
M
M
E
N
P
D
F
I
N
N
N
Y
D
T
N
Y
L
A
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
52.91
44%
-85
- C1 -
2W6Q
2
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
52.86
44%
-83
- C1 -
2W6N
2
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
52.84
44%
-82
- C1 -
2W70
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
52.82
44%
-82
- C1 -
2V5A
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
52.80
44%
-84
- C1 -
2V59
1
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
52.72
44%
-82
- C1 -
2W6Q
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
52.71
44%
-83
- C1 -
2J9G
3
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
--
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.71
45%
-85
- C1 -
4MV4
5
ACCC_HAEIN
A:
[21-463]
M
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
-
P
-
A
P
---
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
-
V
-
P
G
S
-
D
-
G
-
P
---
V
S
N
D
I
A
K
--
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
G
G
---
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
-------
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
-----
I
--
S
---
F
--
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
-
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
52.59
40%
-83
- C1 -
2VPQ
4
?
B:
[2-444]
--
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
-
P
T
L
S
---
K
-
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
-
V
P
G
S
D
-
G
-
L
-
M
---
K
D
V
S
--
E
--
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
-------
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
L
N
-
D
-
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
--
P
--------
Y
--
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
-
S
A
C
-
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
52.57
44%
-85
- C1 -
2W6O
2
ACCC_ECOLI
C:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
52.54
44%
-84
- C1 -
3G8C
4
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
52.40
44%
-83
- C1 -
2V59
1
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
52.34
44%
-82
- C1 -
2V58
2
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
52.31
44%
-85
- C1 -
2W6O
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
52.26
45%
-88
- C1 -
4MV8
2
ACCC_HAEIN
A:
[21-463]
M
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
-
P
-
A
P
---
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
-
V
-
P
G
S
-
D
-
G
-
P
---
V
S
N
D
I
A
K
--
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
-----
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
----------
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
-------
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
-----
I
--
S
---
F
--
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
-
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
52.24
44%
-82
- C1 -
2W6N
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
52.18
44%
-81
- C1 -
2W6M
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.92
45%
-81
- C1 -
2VQD
3
ACCC_PSEAE
A:
[1-443]
M
L
E
K
V
L
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
E
L
M
H
L
S
L
A
D
E
S
V
C
I
G
-
P
-
A
P
---
A
T
Q
S
Y
L
Q
I
P
A
I
I
A
A
A
E
V
T
G
A
T
A
I
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
Q
I
E
R
S
G
F
T
F
V
G
P
T
A
E
V
I
R
L
M
G
D
K
V
S
A
K
D
A
M
K
R
A
G
V
P
T
-
V
-
P
G
S
-
D
-
G
-
P
---
L
P
E
D
--
E
E
T
A
L
A
I
A
R
E
V
G
Y
P
V
I
I
K
A
A
G
G
G
G
G
R
G
M
R
V
V
Y
D
E
S
E
L
I
K
S
A
K
L
T
R
T
E
A
G
A
A
F
G
N
P
M
V
Y
L
E
K
F
L
T
N
P
R
H
V
E
V
Q
V
L
S
D
G
Q
G
N
A
I
H
L
G
D
R
D
C
S
L
Q
R
R
H
Q
K
V
I
E
E
A
P
A
P
G
I
D
E
K
A
R
Q
-------
E
V
F
A
R
C
V
Q
A
C
I
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
-
N
-
G
R
F
Y
F
I
E
M
N
T
R
V
Q
V
E
H
P
V
S
E
M
V
T
G
V
D
I
V
K
E
M
L
R
I
A
S
G
-----
E
K
L
--
S
---
I
--
R
Q
E
D
V
V
I
R
G
H
A
L
E
C
R
I
N
A
E
D
P
K
T
-
F
M
P
S
P
G
K
V
K
H
F
H
A
P
G
G
N
G
V
R
V
D
-
S
H
L
-
Y
S
G
Y
S
V
P
P
N
Y
D
S
L
V
G
K
V
I
T
Y
G
A
D
R
D
E
A
L
A
R
M
R
N
A
L
D
E
L
I
V
D
G
I
K
T
N
T
E
L
H
K
D
L
V
R
D
A
A
F
C
K
G
G
V
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
51.84
44%
-83
- C1 -
3RV3
3
ACCC_ECOLI
A:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
51.71
44%
-81
- C1 -
2V58
2
ACCC_ECOLI
A:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
51.70
44%
-82
- C1 -
1DV2
1
ACCC_ECOLI
A:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
51.61
44%
-81
- C1 -
3JZI
1
ACCC_ECOLI
A:
[22-464]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
51.59
45%
-83
- C1 -
4MV4
5
ACCC_HAEIN
A:
[21-464]
M
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
-
P
A
-
P
---
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
-
V
-
P
G
S
---
D
-
G
PVS
N
D
I
A
--
K
--
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
G
G
---
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
-------
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
-
N
---
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
--
S
F
K
--
Q
--------
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
-
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
-
S
H
V
-
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
51.36
44%
-83
- C1 -
1DV2
1
ACCC_ECOLI
B:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
51.23
44%
-81
- C1 -
3RUP
6
ACCC_ECOLI
B:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
YIGERCA
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
51.20
44%
-83
- C1 -
3RV3
3
ACCC_ECOLI
B:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
50.87
40%
-80
- C1 -
2VPQ
4
?
A:
[2-444]
--
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
-
P
T
L
S
---
K
-
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
-
V
P
G
S
D
-
G
-
L
-
M
---
K
D
V
S
--
E
--
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
-------
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
L
N
-
D
-
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
--
P
--------
Y
--
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
-
S
A
C
-
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
50.83
44%
-80
- C1 -
3RUP
5
ACCC_ECOLI
A:
[4-446]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
49.71
44%
-85
- C1 -
2J9G
3
ACCC_ECOLI
B:
[1-443]
M
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
-
P
-
A
P
---
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
-
G
-
P
L
G
---
D
D
M
D
--
K
--
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
--
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
---
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
-------
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
-
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
-----
L
--
S
---
I
--
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
-
S
H
I
-
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
48.74
41%
-76
- C1 -
2VPQ
4
?
A:
[2-444]
--
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
-
P
T
-
L
---
S
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
-
V
-
P
G
S
D
G
-
L
-
M
---
K
D
V
S
--
E
--
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
-------
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
-
L
N
D
-
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
--
P
Y
K
--
Q
--------
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
-
S
A
C
-
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
45.16
37%
-83
- C1 -
3VA7
5
?
A:
[31-477]
-
F
E
T
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
-----
H
GRT
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
-
V
-
P
---------------------------------------------------------------------------------
N
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
-------
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
D
-
E
Q
R
-
D
E
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
P
--
D
--------
F
--
D
N
T
K
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
V
S
F
P
S
W
A
--
R
V
D
-
T
W
V
-
K
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
44.52
38%
-80
* C1 *
3VA7
5
?
A:
[30-479]
P
F
E
T
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
H
-
G
R
-
T
---
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
V
P
-----------------------------------------------------------------------------------
N
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
-------
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
D
-
E
-
Q
R
D
E
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
P
--
D
F
D
----------
N
T
K
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
V
S
F
P
S
W
--
A
R
V
D
-
T
W
V
-
K
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------