@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3000: (2016-05-16 )
MAVHGFLLERVSVVRDEATVLRQVSAHFPAGRCSAVRGASGSGKTTLLRLLNRLIDPTSGKVWLDGVPLTDLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVGRPDLPEGRVTELLARLCLGQSAREAFLPHQRSALRTALIPAIDSTKVVGLISLPGAMSGLILAGVDPLTAIRYQIVVMYLLLAATAVAALTCARLAERALFDRAHRLVSLPAATRRA
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.....-....10...---..-.---..----20........30........40........50.......---.60........70.---.......80.....------...90..-------..---....100..-.------....110.......120...----------------.----------------.-----.-..130------.....---...140.......150.-----....-..160......-.170.......180-----........190---------.......200.......210.......---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA
V
H
G
-
F
L
L
E
R
V
S
V
V
---
R
D
-
E
---
A
T
----
V
L
R
Q
V
S
AHFPAGR
C
S
AVRGASGS
G
K
T
T
L
L
R
L
L
N
R
LIDPT---SG
K
V
W
LDGVPL
T
D
L
---
D
V
L
V
L
R
R
R
VGLVAQ------A
P
V
V
L
T
D
-------
A
V
---
L
N
E
VRVGRP-D------LPE
G
R
V
T
E
L
L
A
R
L
CL-G
Q
S
A
----------------
R
----------------
E
-----
A
-FLP
H
-------
Q
R
S
A
L
---
R
T
A
L
IPAIDS
T
K
V
V
G
L
I
-----SLPG-AMS
G
L
I
L
AGV
D
-
P
L
T
A
I
R
Y
Q
I
V
V
M
Y
------
L
L
L
A
A
T
A
V
A
A
L
---------
T
C
A
R
L
A
E
R
A
L
F
D
R
A
H
R
L
VSLPAATRRA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
87.62
25%
-129
* C2 *
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
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P
I
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C
G
F
A
I
A
K
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M
S
T
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A
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R
Y
A
K
A
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K
V
V
E
E
T
I
S
S
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T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
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LDRKPVIDSS
S
K
A
G
R
KD
M
K
I
K
G
D
I
T
V
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N
V
H
F
T
Y
PS
R
P
-
D
---
V
P
----
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
R
D
I
---
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
------
E
P
A
L
F
N
C
-------
T
I
---
E
E
N
I
S
L
G
K
E
-
G
------
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
-
E
K
F
I
----------------
K
----------------
T
--------
L
P
N
-------
G
Y
N
T
L
VGD
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
-----
A
L
V
R
-
N
P
K
I
L
L
L
D
E
A
T
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A
L
D
A
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S
E
G
I
V
Q
Q
A
------
L
D
K
A
A
K
G
R
T
T
I
---------
I
I
A
-----------
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
NGQVV
E
V
G
D
H
R
A
L
M
A
Q
QG
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
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V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
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K
L
D
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P
H
K
E
A
I
K
E
A
F
I
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G
L
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Y
G
C
A
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V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
109
Fugue
84.11
27%
-127
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------------------------------------------------------------W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVID
R
A
T
G
D
-
L
E
F
R
N
V
T
F
T
Y
P-
G
R
-
E
---
V
P
----
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
---
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
------
N
V
H
L
F
N
D
-------
T
V
---
A
N
N
I
A
Y
A
R
T
-
E
------
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
-
A
------------------------------------
M
-----
D
-
F
I
N
K
-------
M
D
N
G
L
---
D
T
I
I
G
E
N
----------------------------
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
------
A
L
L
R
D
S
P
I
L
I
L
DEATSALD
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
TIEQAD
E
I
V
V
V
E
DGIIV
E
R
G
T
H
S
E
L
L
A
Q
HG
V
Y
A
Q
L
H
K
M
QFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Fugue
77.73
27%
-105
- C2 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H
M
I
K
L
S
-
N
I
T
K
V
F
H
Q
G
---
T
R
-
T
---
I
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
HFNLLS
S
R
T
V
F
G
N
-------
V
A
---
L
P
L
E
L
D
N
T
P
K
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
----------------
S
----------------
Y
-----
P
-
S
N
L
S
-------
G
G
Q
K
Q
---
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
DQATS
A
L
D
P
-
A
T
T
R
S
I
L
E
L
L
K
-
D
I
N
R
R
L
G
L
T
I
L
L
I
THEMDV
V
K
R
I
C
D
C
V
A
V
I
---------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
QSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
74.10
34%
-98
- C2 -
1Z47
1
?
A:
[15-184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
V
G
V
E
K
I
---
Y
P
G
G
---
A
R
----
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
---
K
G
D
V
W
I
G
G
K
R
V
T
D
L
---
P
P
--
Q
K
R
N
V
G
L
V
F
Q
------
N
Y
A
L
F
Q
H
M------
T
V
---
Y
D
N
V
S
F
G
L
R
-
E
K
RVP
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
----------------
N
----------------
R
FPHEL
S
-
G
G
Q
Q
-------
Q
R
V
A
L
---
A
R
A
L
A
P
-----------------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
-
T
Q
I
R
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.72
38%
-100
- C3 -
1Z47
1
?
A:
[28-162]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
----
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
---
K
G
D
V
W
I
G
G
K
R
V
T
D
L
---
P
--
P
Q
K
R
N
V
G
L
V
F
Q
NYALF-
Q
H
M
T
V
Y
D
-------
N
V
S
F
G
L
R
E
K
R
V
P
K
D
-
E
------
M
-
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
----------------
N
----------------
R
--------
F
P
H
ELS
G
G
Q
Q
Q
R
V
A
L
---
A
R
A
L
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.29
38%
-103
- C3 -
1Z47
1
?
B:
[28-162]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
----
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
---
K
G
D
V
W
I
G
G
K
R
V
T
D
L
---
P
--
P
Q
K
R
N
V
G
L
V
F
Q
NYALF-
Q
H
M
T
V
Y
D
-------
N
V
S
FG
L
R
E
K
R
V
P
K
D
-
E
------
M
-
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
----------------
N
----------------
R
--------
F
P
H
ELS
G
G
Q
Q
Q
R
V
A
L
---
A
R
A
L
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
68.99
26%
-102
- C2 -
4MYC
-
ATM1_YEAST
A:
[435-610]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
I
T
F
E
N
V
T
F
G
---
Y
H
-
P
D--
R
K
----
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
---
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
------
D
T
P
L
F
N
D
-------
T
I
---
W
E
N
V
K
F
G
R
I
-
D
------
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
-
A
P
L
I
----------------
K
K
LPQGFD
T
I
V
G
ER
G
L
M
I
-----
S
-
G
G
E
K
-------
Q
R
L
A
I
---
A
R
V
L
L
K
N
----------------
A
R
I
-
M
F
F
D
E
A
T
S
A
L
D
-
T
H
T
E
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
68.80
27%
-102
- C2 -
3WMG
1
?
A:
[350-529]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
I
V
F
E
N
V
H
F
R
---
Y
P
-
T
RMN
V
E
----
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
---
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
------
E
P
V
L
F
S
G
-------
T
I
---
R
D
N
I
L
Y
G
K
R
-
D
------
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
-
Y
S
F
V
----------------
M
A
LPDGLD
T
E
V
G
ER
G
L
A
L
-----
S
-
G
G
Q
K
-------
Q
R
I
A
I
---
A
R
A
I
L
K
H
----------------
P
T
L
-
L
C
L
D
E
S
T
S
A
L
D
-
A
E
S
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.56
36%
-113
- C3 -
3TUI
1
METN_ECOLI
D:
[24-154]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
I
K
L
S
N
I
T
K
V
---
F
H
-
Q
---
G
T
RTIQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
------
H
F
N
L
L
S
S
RTVFGNV
A
L
---
P
L
E
L
D
N
T
P
K
-
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
67.44
27%
-97
- C2 -
2IT1
-
?
A:
[3-172]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
I
K
L
E
N
I
V
K
K
---
F
G
-
N
---
F
T
----
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
---
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
---
P
--
P
K
D
R
N
V
G
L
V
F
Q
------
N
W
A
L
Y
P
H
M------
T
V
---
Y
K
N
I
A
F
P
L
E
-
L
R
KAP
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
----------------
N
----------------
R
YPWQ-
L
S
G
G
Q
Q
-------
Q
R
V
A
I
---
A
R
A
L
V
K
-----------------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
-
A
L
L
R
L
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
66.19
22%
-130
- C2 -
4Q9H
-
MDR1A_MOUSE
A:
[1030-1230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
V
Q
F
S
G
V
V
F
N
---
Y
P
-
T
RPS
I
P
----
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
---
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
------
E
P
I
L
F
D
C
-------
S
I
---
A
E
N
I
A
Y
G
D
N
-
S
R
V
----
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
-
H
Q
F
I
D
S
LPDKYNTRVGDKG
T
Q
----------------
L
-----
S
-
G
G
Q
K
-------
Q
R
I
A
I
---
A
R
A
L
V
R
Q
----------------
P
H
I
-
L
L
L
D
E
A
T
S
A
L
D
-
T
E
S
E
K
V
V
Q
E
A
L
D
K
--------
A
-
R
E
G
R
T
C
I
---------
V
I
A
H
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
66.17
36%
-116
- C3 -
3TUI
1
METN_ECOLI
H:
[23-154]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-
I
K
L
S
N
I
T
K
V
---
F
H
-
Q
---
G
T
RTIQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
------
H
F
N
L
L
S
S
RTVFGNV
A
L
---
P
L
E
L
D
N
T
P
K
-
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
65.12
27%
-99
- C2 -
4Q4H
-
?
A:
[331-507]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
V
S
F
E
N
V
E
F
R
---
Y
F
-
E
NT-
D
P
----
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
---
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
------
E
T
V
L
F
S
G
-------
T
I
---
K
E
N
L
K
W
G
R
E
-
D
------
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
-
H
D
F
I
----------------
I
S
LPEGYDSRVERGGRN
F
-----
S
-
G
G
Q
K
-------
Q
R
L
S
I
---
A
R
A
L
V
K
K
----------------
P
K
V
-
L
I
L
D
D
C
T
S
S
V
D
-
P
I
T
E
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
64.55
24%
-104
- C2 -
4MRS
1
ATM1_NOVAD
A:
[360-537]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
V
T
F
D
N
V
V
F
G
---
Y
D
-
R
D--
R
E
----
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
V
---
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
------
D
S
V
L
F
N
D
-------
T
I
---
G
Y
N
I
A
Y
G
R
D
-
G
------
A
S
R
A
E
V
D
A
A
A
K
G
A
A
I
-
A
D
F
I
----------------
A
R
LPQGYDTEVGER
G
L
K
L
-----
S
-
G
G
E
K
-------
Q
R
V
A
I
---
A
R
T
L
V
K
----------------
N
P
P
I
-
L
L
F
D
E
A
T
S
A
L
D
-
T
R
T
E
Q
D
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
64.43
36%
-108
- C3 -
3TUZ
1
METN_ECOLI
C:
[23-154]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-
I
K
L
S
N
I
T
K
V
---
F
H
-
Q
---
G
T
RTIQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
------
H
F
N
L
L
S
S
RTVFGNV
A
L
---
P
L
E
L
D
N
T
P
K
-
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
64.41
36%
-113
- C3 -
3TUZ
1
METN_ECOLI
H:
[23-154]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-
I
K
L
S
N
I
T
K
V
---
F
H
-
Q
---
G
T
RTIQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
------
H
F
N
L
L
S
S
RTVFGNV
A
L
---
P
L
E
L
D
N
T
P
K
-
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.69
36%
-110
- C3 -
3TUZ
1
METN_ECOLI
D:
[24-154]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
I
K
L
S
N
I
T
K
V
---
F
H
-
Q
---
G
T
RTIQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
------
H
F
N
L
L
S
S
RTVFGNV
A
L
---
P
L
E
L
D
N
T
P
K
-
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
63.57
36%
-106
- C3 -
3TUI
1
METN_ECOLI
C:
[23-154]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-
I
K
L
S
N
I
T
K
V
---
F
H
-
Q
---
G
T
RTIQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
SES
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
------
H
F
N
L
L
S
S
RTVFGNV
A
L
---
P
L
E
L
D
N
T
P
K
-
D
------
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
63.40
23%
-110
- C2 -
4Q4H
-
Y288_THEMA
B:
[354-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
I
E
F
K
N
V
W
F
S
---
Y
D
-
K
K--
K
P
----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
---
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
------
D
T
I
L
F
S
T
-------
T
V
---
K
E
N
L
K
Y
G
N
P
-
G
------
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
-
D
H
F
I
----------------
K
H
LPEGYETVLTDNGED
L
-----
S
-
Q
G
Q
R
-------
Q
L
L
A
I
---
T
R
A
F
L
A
N
----------------
P
K
I
-
L
I
L
D
E
A
T
S
N
V
D
-
T
K
T
E
K
S
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
63.33
20%
-123
- C2 -
4F4C
-
PGP1_CAEEL
A:
[1076-1275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
V
I
F
K
N
V
R
F
A
---
Y
P
-
E
RPE
I
E
----
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
---
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
------
E
P
T
L
F
D
C
-------
S
I
---
A
E
N
I
I
Y
G
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-
P
SS----
V
T
M
A
Q
V
E
E
A
A
R
L
A
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F
I
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LPEGFETRVGDRGT
Q
----------------
L
-----
S
-
G
G
Q
K
-------
Q
R
I
A
I
---
A
R
A
L
V
R
N
----------------
P
K
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L
L
L
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--------
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---------
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R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------