@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3003c: (2016-05-16 )
MSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAVIRSLEELGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTGRVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPITKHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGYKPNTKPHSRQVREAAKLIAAARKPVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMARGAFPDSHRQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADVPIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLSYGPQSDGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSGGLGTMGFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPVKVALINNGNLGMVRQWQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCVGLRCEREEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDITEGHA
Atome Classification :
(22 SA)
.........10........20........30---........40........50........60........70.-.......80........90........--100.........110.......120.......130.....------..140------.......150.......160.......170.......180.......190---.......200.......210...-..-.-.220.....-------..230.....---..240.......250........260.......270.......280.......290..-.-....300.......310.......320..-.....---------.330--------........340.......350.......360.......370.-......380-....-...--390....-...400.-......410.....---..---420.-.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530-----.....-.----.540.......550.......560.......---570---........580..----.....590.......600------.......610......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSAPTKPHSPTFKPEPHSAANEPKHPAARP
K
---
H
V
A
L
Q
Q
LT
G
A
Q
A
V
I
R
S
L
E
ELGV
D
V
I
FGIPG
G
A
V
L
P
VYDPLF-
D
S
K
K
L
R
H
V
L
V
RHEQGAGHAASG
Y
A
H
V
T--G--R
V
G
V
C
M
ATSGPGAT
N
L
VTPLADAQMDSI
P
V
V
A
I
TGQV------GRGLI------G
T
D
A
F
QEADIS
G
I
T
M
P
ITK
H
N
F
L
V
RSGD
D
I
P
R
V
L
A
E
A
F
H
I
AASGRP
G
A
V
L
---
V
DI
P
K
D
V
LQGQCTFSWPPRMELP-GY-K-PNTK
P
H
S
R
Q
-------
V
R
E
A
A
K
L
I
A
A
---ARK
P
V
L
Y
VGGGVIR-
G
E
A
T
E
Q
L
R
E
L
A
E
LTG
I
P
V
V
T
T
L
M
ARGAFPD
S
H
R
QNLGMPGM
H
G
-
T
-
V
A
A
V
A
A
L
QRS
D
L
L
I
A
LGTRFDDRVTG-KL-DSFAP---------E
A
K
---------
V
I
HADI
D
P
A
E
IGKNRHADVPIVG
D
V
K
A
V
I
T
E
L
I
A
M
L
R
HHHIP-GT
I
E
M
A
D
W
W
-
A
Y
L
N-GVR--KTYPLSY-GPQSDGS-L
S
P
E
Y
V
I
E
K
L
G
EIA---GP---
D
A
-
V
-
F
V
A
GVGQ
H
Q
M
W
A
A
Q
F
I
R
Y
E
K
P
R
S
W
L
NSGGLGTMG
F
A
I
P
A
AMG
A
K
I
ALPG
T
E
V
W
A
IDGDG
C
F
Q
M
T
N
Q
E
L
A
T
C
AVEG
I
P
V
K
V
A
L
INNGN
L
G
M
V
R
Q
W
Q
S
L
F
Y
A
E
R
YSQTDLAT-----HSHR
I
-
P
----
D
F
V
K
L
A
E
A
LGCVGLRCE
R
E
E
D
V
V
D
V
I
N
Q
A
RA---I-N---DC
P
V
V
I
D
F
IVGAD----A
Q
V
W
P
M
V
AAGTSND
E
I
Q
A
------ARGI
R
P
L
F
D
D
ITEGHA
30
HHSearch
96.61
44%
-106
- C6 -
5FEM
8
?
A:
[78-649]
------------------------------------
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S--T
S
R
A
Q
D
E
F
V
M
Q
S
-------
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
---------
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
M
E
E
T
P
G
S
K
-
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
---
N
D
T
GR
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
Q
----------
L
N
-
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
-----
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
-----------------------------
26
PsiBlast_CBE
96.42
42%
-105
- C6 -
1T9B
9
ILVB_YEAST
B:
[75-654]
-------------------------------M--
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
----------
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
21
PsiBlast_CBE
96.33
42%
-105
- C6 -
5FEM
8
?
B:
[73-654]
-------------------------------PDM
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
--------
T
S
R
A
Q
DEFVMQS
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
RAAAEGRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
NDT
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
4
PsiBlast_PDB
96.31
42%
-106
- C6 -
1T9B
9
ILVB_YEAST
A:
[75-654]
-------------------------------M--
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
---------------------F
V
M
Q
S
--
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
1
PsiBlast_PDB
96.26
42%
-110
- C6 -
1JSC
8
ILVB_YEAST
A:
[26-591]
-------------------------------PDM
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
-----------
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
----------------
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
--------------------------------------------
24
PsiBlast_CBE
96.19
42%
-106
- C6 -
1T9D
9
ILVB_YEAST
B:
[76-654]
----------------------------------
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
---------------------F
V
M
Q
S
--
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
7
PsiBlast_PDB
96.12
42%
-107
- C6 -
5FEM
8
?
A:
[73-654]
-------------------------------PDM
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
--------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
5
PsiBlast_PDB
96.11
42%
-105
- C6 -
1T9C
7
ILVB_YEAST
A:
[75-654]
-------------------------------M--
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
---------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
3
PsiBlast_PDB
96.09
42%
-103
- C6 -
1T9A
9
ILVB_YEAST
A:
[74-654]
-------------------------------DM-
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
----------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
25
PsiBlast_CBE
96.06
42%
-105
- C6 -
1T9C
7
ILVB_YEAST
B:
[74-654]
-------------------------------DM-
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
--------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
6
PsiBlast_PDB
96.04
42%
-107
- C6 -
1T9D
9
ILVB_YEAST
A:
[75-654]
-------------------------------M--
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
----------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
2
PsiBlast_PDB
95.87
42%
-105
- C6 -
1N0H
9
ILVB_YEAST
A:
[73-654]
-------------------------------PDM
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
--------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
27
PsiBlast_CBE
95.86
42%
-105
- C6 -
1T9A
9
ILVB_YEAST
B:
[74-654]
-------------------------------DM-
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
--------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
28
PsiBlast_CBE
95.25
42%
-103
- C6 -
1N0H
9
ILVB_YEAST
B:
[73-654]
-------------------------------PDM
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
---------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
22
PsiBlast_CBE
95.24
42%
-105
- C6 -
1T9D
10
ILVB_YEAST
D:
[75-654]
-------------------------------M--
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
---------
S
R
A
Q
DEFVMQS
I
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
RAAAEGRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
NDT
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
23
PsiBlast_CBE
93.65
42%
-104
- C6 -
1T9D
9
ILVB_YEAST
C:
[79-654]
-------------------------------------
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
--
G
--
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
------
P
T
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
---
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
---------------------------
N
K
A
A
D
L
I
N
L
---
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
-
C
-
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GR
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
-----
K
I
F
-
P
V
K
E
R
S
E
W
F
-
A
Q
I
N
-
K
W
K
--
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
-----------
H
T
H
Q
L
N
P
----
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
-
L
D
A
K
L
K
E
F
V
---
S
-
T
---
K
G
P
V
L
L
E
V
E
V
D
K
K
----
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
------------------------
34
HHSearch
87.50
36%
-97
* C6 *
2PAN
5
GCL_ECOLI
A:
[25-584]
--------------------------------------
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
-
K
H
G
G
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A-
G
--
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
------
P
R
A
R
L
------
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
---
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
E
P
L
P
----
V
-
Y
K
P
A
A
S
R
M
Q
-------
I
E
K
A
V
E
M
L
I
Q
---
A
E
R
P
V
I
V
A
G
G
G
V
I
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
H
E
L
M
A
G
M
V
G
L
Q
T
A
H
-
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
-
S
V
-
E
K
Y
T
E
---------
G
R
K
---------
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
G
R
L
P
C
R
K
E
W
V
-
A
D
C
Q
-
Q
R
K
--
R
T
L
L
R
K
--
T
H
F
D
N
V
P
-
V
K
P
Q
R
V
Y
E
E
M
N
K
A
F
---
G
R
---
D
V
-
C
-
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
D
M
D
Y
C
V
Q
L
A
F
E
N
INSSE
V
N
G
Y
G
-
V
----
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
A
K
A
L
M
A
Q
-
Y
---
R
V
P
V
V
V
E
V
I
L
E
R
V
----
T
N
I
-------------------------------------
8
PsiBlast_PDB
84.21
36%
-97
- C6 -
2PAN
5
GCL_ECOLI
A:
[37-578]
--------------------------------------------------
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
-
K
H
G
G
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A-
G
--
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
------
P
R
A
R
L
------
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
---
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
E
P
L
P
-
V
Y
-
K
-
P
A
A
S
--
R
M
Q
-------
I
E
K
A
V
E
M
L
I
Q
---
A
E
R
P
V
I
V
A
G
G
G
V
I
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
H
E
L
M
A
G
M
V
G
L
Q
T
-
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
-
S
V
-
E
K
Y
T
E
---------
G
R
K
---------
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
-
G
R
L
P
C
R
K
E
W
-
V
A
D
C
-
Q
Q
R
--
K
R
T
L
L
R
K
-
T
H
F
D
N
V
P
-
V
K
P
Q
R
V
Y
E
E
M
N
K
A
F
---
G
R
---
D
V
-
C
-
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
D
M
D
Y
C
V
Q
L
A
F
E
N
I----
N
S
S
E
V
-
N
GYGV
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
A
K
A
---
L
-
M
A
Q
Y
R
V
P
V
V
V
E
V
I
L
-----------------------------------------------
11
PsiBlast_PDB
81.21
28%
-98
- C6 -
4FEG
10
?
A:
[12-582]
----------------------------------------
L
A
G
A
-
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
--
G
--
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
------
G
T
T
G
M
------
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
Q
T
P
-
L
L
-----
P
E
P
D
V
Q
A
-------
V
T
R
L
T
Q
T
L
L
A
---
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
---
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
N
R
V
A
-
Q
-
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
-
K
---
A
F
K
N
---------
T
R
Y
---------
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
-------
E
S
T
P
W
W
Q
A
N
L
A
-
N
V
K
N
W
R
A
Y
L
A
S
L
-
E
D
K
Q
E
G
P
-
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
---
E
P
---
D
A
-
I
-
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
-----
E
D
T
N
Q
N
D
F
I
G
-----
V
E
F
N
D
-
I
----
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
---
I
A
Q
---
H
E
P
V
L
I
D
A
V
I
T
G
D
RPLP
A
E
K
L
R
L
D
S
A
M
S
S
A
A
D
I
E
A
F
K
Q
R
Y
E
A
Q
D
L
Q
P
L
---------
41
HHSearch
81.00
28%
-103
- C6 -
3EYA
11
POXB_ECOLI
A:
[2-539]
---------------------------------------
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
-
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
--
G
--
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
------
P
S
S
E
I
------
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
-
L
N
R
G
V
S
V
---
V
V
L
P
G
D
V
A
L
K
P
A
P
E
G
A
T
M
-
H
W
Y
H
-
A
P
-
Q
-
P
V
V
T
P
E
E
E
E
-------
L
R
K
L
A
Q
L
L
R
Y
---
S
S
N
I
A
L
M
C
G
S
G
C
A
---
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
G
L
I
G
-
F
-
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
-------
Y
P
T
---------
D
A
K
---------
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
A
D
R
---
K
F
L
D
K
A
L
-
E
D
Y
R
-
D
A
R
--
K
G
L
D
D
-
L
-
A
K
P
S
E
K
A
-
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
---
A
D
---
D
A
-
I
-
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
-------------
G
T
E
L
----------
H
D
-
T
----
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
A
F
S
-----
I
---
D
G
P
V
L
V
D
V
V
V
A
K
E
----
E
L
A
I
P
P
Q
I
K
-------------------------------
38
HHSearch
79.50
30%
-98
- C6 -
5AHK
5
?
A:
[21-573]
----------------------------------------
M
K
A
S
D
A
V
A
K
I
L
A
D
N
N
V
L
Y
G
F
E
L
I
G
G
M
I
T
H
L
V
D
S
I
N
-
L
L
G
K
T
K
L
V
S
M
H
H
E
Q
G
A
A
F
A
A
S
A
V
S
R
V
T
--
H
HK
T
L
G
L
A
L
A
T
S
G
P
G
A
T
N
L
I
T
G
I
A
D
C
W
L
D
S
H
P
C
I
F
L
T
G
Q
V
------
N
T
H
E
L
KGKRDI
R
Q
Q
G
F
Q
E
L
D
S
V
A
L
V
T
S
I
T
K
Y
A
Y
Q
I
K
S
A
D
E
L
V
P
C
L
R
K
A
I
Q
I
A
K
E
G
R
P
G
P
V
L
---
L
D
I
P
M
D
I
Q
R
A
D
I
D
E
A
L
L
N
N
------------
P
S
I
A
M
S
D
-------
L
D
F
I
I
N
K
L
Q
N
---
A
K
K
P
L
L
L
I
G
G
G
A
V
N
-
S
S
G
F
Q
K
W
L
E
Q
I
E
L
R
G
I
P
Y
V
A
S
L
K
G
A
E
K
I
K
A
-
S
D
L
Y
L
G
M
L
G
A
Y
G
-
T
-
R
A
A
N
H
A
V
Q
N
C
D
L
L
L
V
L
G
S
R
M
D
V
R
Q
T
G
-
A
Q
P
E
D
F
A
R
---------
N
A
E
---------
I
I
Q
I
D
L
Q
E
G
Q
L
N
N
R
V
I
A
D
F
S
Y
Q
I
E
L
S
E
Y
F
S
R
F
S
P
L
Q
I
P
V
N
-----
N
D
W
S
V
W
T
-
A
L
L
K
-
E
K
F
--
R
V
T
--
F
I
-
D
E
Y
T
T
W
N
-
L
S
P
F
G
L
F
T
Q
L
N
K
L
T
---
E
R
---
V
A
L
D
-
Y
I
L
D
V
G
N
N
Q
M
W
A
A
H
T
L
R
L
N
A
Q
Q
A
M
H
H
S
G
G
L
G
S
M
G
F
A
I
P
A
A
I
G
A
C
Y
A
G
-
K
K
P
I
I
V
I
T
G
D
G
G
A
Q
L
N
I
Q
E
L
D
I
I
A
R
D
K
L
P
I
L
T
I
V
M
N
N
H
S
L
G
M
V
R
G
F
Q
E
M
Y
F
E
G
R
N
S
S
T
Y
W
N
--------
G
Y
T
-
S
----
Q
F
K
K
I
G
E
A
Y
R
V
E
S
K
T
I
I
S
M
Q
A
F
S
S
A
L
E
S
F
L
E
-----
S
---
P
R
P
L
L
L
E
V
S
M
S
D
A
----
R
E
C
R
P
R
L
---------------------------------
29
PsiBlast_CBE
75.46
33%
-101
- C6 -
5AHK
5
?
B:
[21-529]
----------------------------------------
M
K
A
S
D
A
V
A
K
I
L
A
D
N
N
V
L
Y
G
F
E
L
I
G
G
M
I
T
H
L
V
D
S
I
N
-
L
L
G
K
T
K
L
V
S
M
H
H
E
Q
G
A
A
F
A
A
S
A
V
S
R
V
T
H
H
K
--
T
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-----------------------------------------------------------------------------------------