@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3014c: (2016-05-16 )
MSSPDADQTAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHPELRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRIHAEVGDAAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTIADVPERLTPGDDYPVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGHVEGFRPATLHQAYLALRAWGLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVKVDEVALQRRLGSTSRAPRWAIAYKYPPEEAQTKLLDIRVNVGRTGRITPFAFMTPVKVAGSTVGQATLHNASEIKRKGVLIGDTVVIRKAGDVIPEVLGPVVELRDGSEREFIMPTTCPECGSPLAPEKEGDADIRCPNARGCPGQLRERVFHVASRNGLDIEVLGYEAGVALLQAKVIADEGELFALTERDLLRTDLFRTKAGELSANGKRLLVNLDKAKAAPLWRVLVALSIRHVGPTAARALATEFGSLDAIAAASTDQLAAVEGVGPTIAAAVTEWFAVDWHREIVDKWRAAGVRMVDERDESVPRTLAGLTIVVTGSLTGFSRDDAKEAIVARGGKAAGSVSKKTNYVVAGDSPGSKYDKAVELGVPILDEDGFRRLLADGPASRT
Atome Classification :
(40 SA)
.........10........20........30........40........50........60........70........80........90........100.......110---.......--120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240..---.-....250.---..-....260.......270.......280.---..---....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600-.........610.......620.......630.......640.......650.......660.......670.......680.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSPDAD
Q
T
A
P
E
V
L
R
Q
W
Q
A
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
VRDAPIIS
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
QHPELRTPDSPT
Q
L
VGGAGFATDF
E
P
V
D
H
L
E
R
M
L
SLDNAF
T
A
D
E
L
A
A
W
A
G
R
I
HAEV---GDA
A
H
Y
L
--
C
E
L
K
ID
G
V
A
L
S
L
V
Y
REGR
L
T
RASTRGDGRTGE
D
V
T
L
N
A
R
T
I
ADVPERLTPGDDYP
V
P
E
V
L
E
VR
G
E
V
F
F
R
LD
D
F
Q
A
L
N
A
S
L
V
EEGKAPFANPRNSAAGSLRQKD
P
A
V
T
A
R
R
R
L
R
M
I
C
H
G
LGHVEGF---R-
P
A
T
L
H
Q
A
Y
---
L
A
-
L
R
AWGLPVSEH
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
---
G
E
---
H
R
H
E
V
DHEID
G
V
V
V
K
V
D
E
V
A
L
Q
R
RLGSTSRAP
R
W
A
I
A
Y
KYPPEEAQ
T
K
L
L
D
I
R
V
NVGRTGRI
T
P
F
A
F
MT
P
V
K
VAGSTVG
Q
A
TLH
N
A
S
E
I
K
RK
G
V
L
IG
D
T
V
V
I
RKA
G
D
V
I
P
E
V
L
G
P
V
V
ELRDGSE
R
E
F
IMPTTCPECGSPLAPEKEGDADIRCPNARG
C
P
G
Q
L
R
E
R
V
F
H
V
ASRNG
L
D
I
E
V
L
G
Y
E
A
G
V
A
L
L
Q
A
K
V
IADEG
E
L
F
A
L
T
E
R
D
L
L
R
T
D
L
F
RTKAGELSANG
K
R
L
L
V
NLDKAKA
A
P
L
W
R
V
L
V
A
L
S
I
RHVG
P
T
A
A
R
A
L
A
T
E
FGSLD
A
I
AAASTD
Q
L
A
A
VEGVG
P
T
I
A
A
A
V
T
E
W
F
A
V
D
W
H
R
E
I
V
D
K
W
R
A
AG
V
R
M
---VDERDESVPRTLA
G
L
T
I
V
V
TGSLTGFS
R
D
D
A
K
E
A
I
V
ARGGKAAGSVSKKT
N
Y
V
V
AGDSPGSKY
D
K
A
V
ELGVPILDED
G
F
R
R
L
L
ADGPASRT
4
PsiBlast_PDB
83.77
43%
-79
- C4 -
1DGS
2
DNLJ_THEFI
A:
[1-581]
-------
M
T
R
E
E
A
R
R
R
I
N
E
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
---
E
A
P
S
L
Y
T
--
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
S
T
G
S
--
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
K
G
-----
V
P
D
R
L
E
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
G
L
G
L
---
E
-
E
S
G
L
K
S
Q
Y
E
L
L
L
W
-
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
---
L
A
---
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
R
L
V
--
K
E
G
K
V
H
-
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
----
R
M
G
E
K
S
A
Q
N
--
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
-----
E
S
K
--------------------------------------------------------------------------------------
43
HHSearch
83.69
44%
-83
- C4 -
2OWO
8
DNLJ_ECOLI
A:
[3-586]
-----------
S
I
E
Q
Q
L
T
E
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
V
G
A
A
P
-
L
A
A
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
D
R
L
KN-
N
E
K
V
T
W
C
--
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
G
E
---
N
I
P
A
R
L
E
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
F
F
C
Y
G
V
G
V
L
E
G
G
E--
L
-
P
D
T
H
L
G
R
L
---
L
Q
-
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
---
E
E
---
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
R
V
-
E
G
E
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
------
R
M
G
P
K
S
A
Q
N
V
V
N
A
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
E
G
V
H
W
---
P
A
P
----------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.56
44%
-82
- C4 -
1V9P
2
DNLJ_THEFI
A:
[2-581]
--------
T
R
E
E
A
R
R
R
I
N
E
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
A
L
---
G
R
K
R
P
F
L
Y
T
V
E
H
K
V
D
G
L
S
V
N
L
Y
Y
E
E
G
V
L
V
F
G
A
T
R
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
K
G
-----
V
P
D
R
L
E
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
--
G
L
---
E
-
E
S
G
L
K
S
Q
Y
E
L
L
L
W
-
L
K
E
K
G
F
P
V
E
H
G
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
F
---
L
A
---
Q
R
H
A
L
P
F
E
A
D
G
V
V
V
K
L
D
D
L
A
L
W
R
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
E
E
R
P
I
R
W
P
E
T
C
P
E
C
G
H
R
L
V
--
K
E
G
K
V
H
-
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
----
R
M
G
E
K
S
A
Q
N
--
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
L
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
----------------------------------------------------------------------------------------------
62
Fugue
83.45
43%
-79
- C4 -
1DGS
2
DNLJ_THEFI
A:
[1-581]
-------
M
T
R
E
E
A
R
R
R
I
N
E
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
---
E
A
P
S
L
Y
T
--
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
S
T
--
G
S
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
K
G
-----
V
P
D
R
L
E
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
G
L
G
L
EES
G
-
L
K
S
Q
Y
E
L
L
---
L
W
-
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
---
L
A
---
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
R
L
---
V
K
E
G
K
V
H
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
R
M
G
E
K
------
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
---
E
S
K
----------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.36
43%
-77
- C4 -
1DGS
2
DNLJ_THEFI
B:
[1-581]
-------
M
T
R
E
E
A
R
R
R
I
N
E
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
---
E
A
P
S
L
Y
T
--
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
S
T
G
S
--
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
K
G
-----
V
P
D
R
L
E
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
G
L
G
L
---
E
-
E
S
G
L
K
S
Q
Y
ELL
L
W
-
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
---
L
A
---
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
R
L
V
--
K
E
G
K
V
H
-
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
----
R
M
G
E
K
S
A
Q
N
--
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
-----
E
S
K
--------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.33
44%
-79
- C4 -
1V9P
2
DNLJ_THEFI
B:
[2-581]
--------
T
R
E
E
A
R
R
R
I
N
E
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
A
L
---
G
R
K
R
P
F
L
YT
V
E
H
K
V
D
G
L
S
V
N
L
Y
Y
E
E
G
V
L
V
F
G
A
T
R
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
K
G
-----
V
P
D
R
L
E
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
--
G
L
---
E
-
E
S
G
L
K
S
Q
Y
ELL
L
W
-
L
K
E
K
G
F
P
V
E
H
G
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
F
---
L
A
---
Q
R
H
A
L
P
F
E
A
D
G
V
V
V
K
L
D
D
L
A
L
W
R
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
E
E
R
P
I
R
W
P
E
T
C
P
E
C
G
H
R
L
V
--
K
E
G
K
V
H
-
R
C
P
N
P
L
-
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
----
R
M
G
E
K
S
A
Q
N
--
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
L
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
----------------------------------------------------------------------------------------------
45
HHSearch
83.02
43%
-85
- C4 -
4GLX
5
DNLJ_ECOLI
A:
[3-583]
-----------
S
I
E
Q
Q
L
T
E
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
----
P
-
L
A
A
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
D
R
--------
T
W
C
--
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
G
E
---
N
I
P
A
R
L
E
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
F
F
C
Y
G
V
G
V
L
E
G
G
E--
L
-
P
D
T
H
L
G
R
L
---
L
Q
-
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
---
E
E
---
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
R
V
-
E
G
E
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
------
R
M
G
P
K
S
A
Q
N
V
V
N
A
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
E
G
V
H
W
----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.81
43%
-84
- C4 -
2OWO
8
DNLJ_ECOLI
A:
[6-586]
--------------
Q
Q
L
T
E
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
V
G
A
A
P
L
A
A
-
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
D
R
L
KN-
N
E
K
V
T
W
C
--
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
-
G
E
N
--
I
P
A
R
L
E
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
F
F
C
Y
G
V
G
V
L
E
G
G
---
E
L
P
D
T
H
L
G
R
L
---
L
Q
-
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
---
E
E
---
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
-
R
V
E
G
E
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
R
M
G
P
K
S
A
Q
N
V
V
N
A
------
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
E
G
V
H
W
PAP-------------------------------------------------------------------------------------------
42
HHSearch
82.74
43%
-80
- C4 -
1DGS
2
DNLJ_THEFI
A:
[4-581]
----------
E
E
A
R
R
R
I
N
E
L
R
D
L
I
R
Y
H
N
Y
R
Y
Y
V
L
A
D
P
E
I
S
D
A
E
Y
D
R
L
L
R
E
L
K
E
L
E
E
R
F
P
E
F
K
S
P
D
S
P
T
E
Q
V
G
A
R
P
L
E
P
T
F
R
P
V
R
H
P
T
R
M
Y
S
L
D
N
A
F
T
Y
E
E
V
L
A
F
E
E
R
L
E
R
E
A
---
E
A
P
S
L
Y
T
--
V
E
H
K
V
D
G
L
S
V
-
L
Y
Y
E
E
G
V
W
--
S
T
G
S
G
D
G
E
V
G
E
E
V
T
Q
N
L
L
T
I
P
T
I
P
R
R
L
K
G
-----
V
P
D
R
L
E
V
R
G
E
V
Y
M
P
I
E
A
F
L
R
L
N
E
E
L
E
E
R
G
E
K
V
F
K
N
P
R
N
A
A
A
G
S
L
R
Q
K
D
P
R
V
T
A
K
R
G
L
R
A
T
F
Y
A
L
G
L
G
L
G
L
EES
G
-
L
K
S
Q
Y
E
L
L
---
L
W
-
L
K
E
K
G
F
P
V
E
H
C
Y
E
K
A
L
G
A
E
G
V
E
E
V
Y
R
R
G
---
L
A
---
Q
R
H
A
L
P
F
E
A
D
G
V
V
L
K
L
D
D
L
T
L
W
G
E
L
G
Y
T
A
R
A
P
R
F
A
L
A
Y
K
F
P
A
E
E
K
E
T
R
L
L
D
V
V
F
Q
V
G
R
T
G
R
V
T
P
V
G
V
L
E
P
V
F
I
E
G
S
E
V
S
R
V
T
L
H
N
E
S
Y
I
E
E
L
D
I
R
I
G
D
W
V
L
V
H
K
A
G
G
V
I
P
E
V
L
R
V
L
K
E
R
R
T
G
K
E
R
P
I
R
W
P
E
A
C
P
E
C
G
H
R
L
V
K
---
E
G
K
V
H
R
C
P
N
P
-
L
C
P
A
K
R
F
E
A
I
R
H
Y
A
S
R
K
A
M
D
I
E
G
L
G
E
K
L
I
E
R
L
L
E
K
G
L
V
R
D
V
A
D
L
Y
H
L
R
K
E
D
L
L
G
L
E
------
R
M
G
E
K
S
A
Q
N
L
L
R
Q
I
E
E
S
K
H
R
G
L
E
R
L
L
Y
A
L
G
L
P
G
V
G
E
V
L
A
R
N
L
A
R
R
F
G
T
M
D
R
L
L
E
A
S
L
E
E
L
I
E
V
E
E
V
G
E
L
T
A
R
A
I
L
E
T
L
K
D
P
A
F
R
D
L
V
R
R
L
K
E
A
G
V
S
M
---
E
S
--
K
--------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.76
42%
-85
- C4 -
4GLX
5
DNLJ_ECOLI
A:
[6-581]
--------------
Q
Q
L
T
E
L
R
T
T
L
R
H
H
E
Y
L
Y
H
V
M
D
A
P
E
I
P
D
A
E
Y
D
R
L
M
R
E
L
R
E
L
E
T
K
H
P
E
L
I
T
P
D
S
P
T
Q
R
----
P
L
A
A
-
F
S
Q
I
R
H
E
V
P
M
L
S
L
D
N
V
F
D
E
E
S
F
L
A
F
N
K
R
V
Q
D
R
--------
T
W
C
--
C
E
L
K
L
D
G
L
A
V
S
I
L
Y
E
N
G
V
L
V
S
A
A
T
R
G
D
G
T
T
G
E
D
I
T
S
N
V
R
T
I
R
A
I
P
L
K
L
H
-
G
E
N
--
I
P
A
R
L
E
V
R
G
E
V
F
L
P
Q
A
G
F
E
K
I
N
E
D
A
R
R
T
G
G
K
V
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
R
I
T
A
K
R
P
L
T
F
F
C
Y
G
V
G
V
L
E
G
G
---
E
L
P
D
T
H
L
G
R
L
---
L
Q
-
F
K
K
W
G
L
P
V
S
D
R
V
T
L
C
E
S
A
E
E
V
L
A
F
Y
H
K
V
---
E
E
---
D
R
P
T
L
G
F
D
I
D
G
V
V
I
K
V
N
S
L
A
Q
Q
E
Q
L
G
F
V
A
R
A
P
R
W
A
V
A
F
K
F
P
A
Q
E
Q
M
T
F
V
R
D
V
E
F
Q
V
G
R
T
G
A
I
T
P
V
A
R
L
E
P
V
H
V
A
G
V
L
V
S
N
A
T
L
H
N
A
D
E
I
E
R
L
G
L
R
I
G
D
K
V
V
I
R
R
A
G
D
V
I
P
Q
V
V
N
V
V
L
S
E
R
P
E
D
T
R
E
V
V
F
P
T
H
C
P
V
C
G
S
D
V
E
-
R
V
E
G
E
A
V
A
R
C
T
G
G
L
I
C
G
A
Q
R
K
E
S
L
K
H
F
V
S
R
R
A
M
D
V
D
G
M
G
D
K
I
I
D
Q
L
V
E
K
E
Y
V
H
T
P
A
D
L
F
K
L
T
A
G
K
L
T
G
L
E
R
M
G
P
K
S
A
Q
N
V
V
N
A
------
L
E
K
A
K
E
T
T
F
A
R
F
L
Y
A
L
G
I
R
E
V
G
E
A
T
A
A
G
L
A
A
Y
F
G
T
L
E
A
L
E
A
A
S
I
E
E
L
Q
K
V
P
D
V
G
I
V
V
A
S
H
V
H
N
F
F
A
E
E
S
N
R
N
V
I
S
E
L
L
A
E
G
V
------------------------------------------------------------------------------------------------
44
HHSearch
79.41
99%
-66
- C4 -
3SGI
1
DNLJ_MYCTU
A:
[8-415]
-------
Q
T
A
P
E
V
L
R
Q
W
Q
A
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
---
G
D
A
A
H
Y
L
--
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
P
G
D
D
Y
P
V
P
E
V
L
E
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
M
I
C
H
G
L
G
H
V
E
G
F
---
R
-
P
A
T
L
H
Q
A
Y
---
L
A
-
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
---
G
E
---
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
E
A
Q
T
K
L
L
D
I
R
V
N
V
G
R
T
G
R
I
T
P
F
A
F
M
T
P
V
K
V
A
G
S
T
V
G
Q
A
T
L
H
N
A
S
E
I
K
R
K
G
V
L
I
G
D
T
V
V
I
R
K
A
G
D
V
I
P
E
V
L
G
P
V
V
E
L
R
D
G
S
E
R
E
F
I
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.41
99%
-66
- C4 -
3SGI
1
DNLJ_MYCTU
A:
[8-415]
-------
Q
T
A
P
E
V
L
R
Q
W
Q
A
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
---
G
D
A
A
H
Y
L
--
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
P
G
D
D
Y
P
V
P
E
V
L
E
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
M
I
C
H
G
L
G
H
V
E
G
F
---
R
-
P
A
T
L
H
Q
A
Y
---
L
A
-
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
---
G
E
---
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
E
A
Q
T
K
L
L
D
I
R
V
N
V
G
R
T
G
R
I
T
P
F
A
F
M
T
P
V
K
V
A
G
S
T
V
G
Q
A
T
L
H
N
A
S
E
I
K
R
K
G
V
L
I
G
D
T
V
V
I
R
K
A
G
D
V
I
P
E
V
L
G
P
V
V
E
L
R
D
G
S
E
R
E
F
I
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
72.98
100%
-83
- C4 -
1ZAU
1
DNLJ_MYCTU
A:
[8-328]
-------
Q
T
A
P
E
V
L
R
Q
W
Q
A
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
---
G
D
A
A
H
Y
L
--
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
P
G
D
D
Y
P
V
P
E
V
L
E
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
M
I
C
H
G
L
G
H
V
E
G
F
---
R
-
P
A
T
L
H
Q
A
Y
---
L
A
-
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
---
G
E
---
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.98
100%
-83
- C4 -
1ZAU
1
DNLJ_MYCTU
A:
[8-328]
-------
Q
T
A
P
E
V
L
R
Q
W
Q
A
L
A
E
E
V
R
E
H
Q
F
R
Y
Y
V
R
D
A
P
I
I
S
D
A
E
F
D
E
L
L
R
R
L
E
A
L
E
E
Q
H
P
E
L
R
T
P
D
S
P
T
Q
L
V
G
G
A
G
F
A
T
D
F
E
P
V
D
H
L
E
R
M
L
S
L
D
N
A
F
T
A
D
E
L
A
A
W
A
G
R
I
H
A
E
V
---
G
D
A
A
H
Y
L
--
C
E
L
K
I
D
G
V
A
L
S
L
V
Y
R
E
G
R
L
T
R
A
S
T
R
G
D
G
R
T
G
E
D
V
T
L
N
A
R
T
I
A
D
V
P
E
R
L
T
P
G
D
D
Y
P
V
P
E
V
L
E
V
R
G
E
V
F
F
R
L
D
D
F
Q
A
L
N
A
S
L
V
E
E
G
K
A
P
F
A
N
P
R
N
S
A
A
G
S
L
R
Q
K
D
P
A
V
T
A
R
R
R
L
R
M
I
C
H
G
L
G
H
V
E
G
F
---
R
-
P
A
T
L
H
Q
A
Y
---
L
A
-
L
R
A
W
G
L
P
V
S
E
H
T
T
L
A
T
D
L
A
G
V
R
E
R
I
D
Y
W
---
G
E
---
H
R
H
E
V
D
H
E
I
D
G
V
V
V
K
V
D
E
V
A
L
Q
R
R
L
G
S
T
S
R
A
P
R
W
A
I
A
Y
K
Y
P
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
67.07
43%
-66
- C4 -
3UQ8
2
DNLJ_HAEIN
A:
[2-321]
------------
I
Q
T
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
-
L
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
A
R
I
E
D
R
L
ILL
P
A
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
T
D
---
N
P
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
D--
L
-
P
T
T
H
Y
A
R
L
---
Q
W
-
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
G
A
D
E
V
L
G
F
Y
R
D
I
---
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
Q
E
E
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
66.82
41%
-72
- C4 -
4EFE
4
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
66.75
42%
-73
- C4 -
4LH6
5
DNLJ_ENTFA
A:
[8-323]
---------
L
T
A
A
T
T
R
A
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
-
L
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
P
E
E
A
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.59
41%
-72
- C4 -
3BAA
8
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
66.45
41%
-70
- C4 -
1TA8
4
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
66.22
40%
-71
- C4 -
3JSL
5
DNLJ_STAAU
A:
[3-309]
-----------
D
L
S
S
R
V
N
E
L
H
D
L
L
N
Q
Y
S
Y
E
Y
Y
V
E
D
N
P
S
V
P
D
S
E
Y
D
K
L
L
H
E
L
I
K
I
E
E
E
H
P
E
Y
K
T
V
D
S
P
T
V
R
V
G
G
E
A
-
Q
A
S
F
N
K
V
N
H
D
T
P
M
L
S
L
G
N
A
F
N
E
D
D
L
R
K
F
D
Q
R
I
R
E
Q
----
I
G
N
V
E
Y
M
--
C
E
L
K
I
D
G
L
A
V
S
L
K
Y
V
D
G
Y
F
V
Q
G
L
T
R
G
D
G
T
T
G
E
D
I
T
E
N
L
K
T
I
H
A
I
P
L
K
M
K
------
E
P
L
N
V
E
V
R
G
E
A
Y
M
P
R
R
S
F
L
R
L
N
E
E
K
E
K
N
D
E
Q
L
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
S
K
L
T
A
K
R
K
L
S
V
F
I
Y
S
V
N
D
F
T
D
F
---
N
-
A
R
S
Q
S
E
A
L
---
D
E
-
L
D
K
L
G
F
T
T
N
K
N
R
A
R
V
N
N
I
D
G
V
L
E
Y
I
E
K
W
---
T
S
---
Q
R
E
S
L
P
Y
D
I
D
G
I
V
I
K
V
N
D
L
D
Q
Q
D
E
M
G
F
T
Q
K
S
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
66.22
41%
-72
- C4 -
4LH7
4
DNLJ_ENTFA
A:
[16-322]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
P
E
E
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.11
41%
-73
- C4 -
3BAB
7
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
65.99
41%
-70
- C4 -
4EFB
4
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.93
41%
-72
- C4 -
3BA9
9
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.90
41%
-71
- C4 -
3BA8
5
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
65.80
41%
-69
- C4 -
4EEQ
4
DNLJ_ENTFA
A:
[16-317]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.56
41%
-73
- C4 -
4LH6
5
DNLJ_ENTFA
A:
[16-323]
-----------------
Q
E
L
R
K
Q
L
N
Q
Y
S
H
E
Y
Y
V
K
D
Q
P
S
V
E
D
Y
V
Y
D
R
L
Y
K
E
L
V
D
I
E
T
E
F
P
D
L
I
T
P
D
S
P
T
Q
R
V
G
G
K
V
L
-
S
G
F
E
K
A
P
H
D
I
P
M
Y
S
L
N
D
G
F
S
K
E
D
I
F
A
F
D
E
R
V
R
K
A
I
---
G
K
P
V
A
Y
C
--
C
E
L
K
I
D
G
L
A
I
S
L
R
Y
E
N
G
V
F
V
R
G
A
T
R
G
D
G
T
V
G
E
N
I
T
E
N
L
R
T
V
R
S
V
P
M
R
L
T
E
------
P
I
S
V
E
V
R
G
E
C
Y
M
P
K
Q
S
F
V
A
L
N
E
E
R
E
E
N
G
Q
D
I
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
T
K
I
V
A
K
R
N
L
N
T
F
L
Y
T
V
A
D
F
G
P
M
---
K
-
A
K
T
Q
F
E
A
L
---
E
E
-
L
S
A
I
G
F
R
T
N
P
E
R
Q
L
C
Q
S
I
D
E
V
W
A
Y
I
E
E
Y
---
H
E
---
K
R
S
T
L
P
Y
E
I
D
G
I
V
I
K
V
N
E
F
A
L
Q
D
E
L
G
F
T
V
K
A
P
R
W
A
I
A
Y
K
F
P
P
E
E
A
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.10
43%
-61
- C4 -
3UQ8
2
DNLJ_HAEIN
A:
[5-321]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
A
R
I
E
D
R
L
ILL
P
A
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
Q
E
E
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
64.52
40%
-71
- C4 -
4CC5
2
DNLJ_STAAU
A:
[11-309]
-------------------
L
H
D
L
L
N
Q
Y
S
Y
E
Y
Y
V
E
D
N
P
S
V
P
D
S
E
Y
D
K
L
L
H
E
L
I
K
I
E
E
E
H
P
E
Y
K
T
V
D
S
P
T
V
R
V
G
G
E
A
Q
A
S
-
F
N
K
V
N
H
D
T
P
M
L
S
L
G
N
A
F
N
E
D
D
L
R
K
F
D
Q
R
I
R
E
Q
I
---
G
N
V
-
E
Y
M
--
C
E
L
K
I
D
G
L
A
V
S
L
K
Y
V
D
G
Y
F
V
Q
G
L
T
R
G
D
G
T
T
G
E
D
I
T
E
N
L
K
T
I
H
A
I
P
L
K
M
K
E
------
P
L
N
V
E
V
R
G
E
A
Y
M
P
R
R
S
F
L
R
L
N
E
E
K
E
K
N
D
E
Q
L
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
S
K
L
T
A
K
R
K
L
S
V
F
I
Y
S
V
N
D
F
T
D
F
---
N
-
A
R
S
Q
S
E
A
L
---
D
E
-
L
D
K
L
G
F
T
T
N
K
N
R
A
R
V
N
N
I
D
G
V
L
E
Y
I
E
K
W
---
T
S
---
Q
R
E
S
L
P
Y
D
I
D
G
I
V
I
K
V
N
D
L
D
Q
Q
D
E
M
G
F
T
Q
K
S
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.21
43%
-68
- C4 -
4UFZ
2
DNLJ_HAEIN
A:
[7-317]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.12
43%
-65
- C4 -
3PN1
2
DNLJ_HAEIN
A:
[7-317]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.67
43%
-65
- C4 -
4UCR
2
DNLJ_HAEIN
A:
[7-317]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.56
43%
-64
- C4 -
4UCS
2
DNLJ_HAEIN
A:
[7-317]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
62.49
40%
-70
- C4 -
4CC6
2
DNLJ_STAAU
A:
[11-309]
-------------------
L
H
D
L
L
N
Q
Y
S
Y
E
Y
Y
V
E
D
N
P
S
V
P
D
S
E
Y
D
K
L
L
H
E
L
I
K
I
E
E
E
H
P
E
Y
K
T
V
D
S
P
T
V
R
V
G
G
E
A
Q
A
S
-
F
N
K
V
N
H
D
T
P
M
L
S
L
G
N
A
F
N
E
D
D
L
R
K
F
D
Q
R
I
R
E
Q
I
---
G
N
V
-
E
Y
M
--
C
E
L
K
I
D
G
L
A
V
S
L
K
Y
V
D
G
Y
F
V
Q
G
L
T
R
G
D
G
T
T
G
E
D
I
T
E
N
L
K
T
I
H
A
I
P
L
K
M
K
E
------
P
L
N
V
E
V
R
G
E
A
Y
M
P
R
R
S
F
L
R
L
N
E
E
K
E
K
N
D
E
Q
L
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
S
K
L
T
A
K
R
K
L
S
V
F
I
Y
S
V
N
D
F
T
D
F
---
N
-
A
R
S
Q
S
E
A
L
---
D
E
-
L
D
K
L
G
F
T
T
N
K
N
R
A
R
V
N
N
I
D
G
V
L
E
Y
I
E
K
W
---
T
S
---
Q
R
E
S
L
P
Y
D
I
D
G
I
V
I
K
V
N
D
L
D
Q
Q
D
E
M
G
F
T
Q
K
S
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.40
43%
-65
- C4 -
4UCU
2
DNLJ_HAEIN
A:
[7-318]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.03
43%
-64
- C4 -
4UCT
2
DNLJ_HAEIN
A:
[7-318]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.38
43%
-68
- C4 -
4UCO
2
DNLJ_HAEIN
A:
[7-317]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.34
43%
-65
- C4 -
4UCV
2
DNLJ_HAEIN
A:
[7-318]
---------------
Q
L
D
N
L
R
K
T
L
R
Q
Y
E
Y
E
Y
H
V
L
D
N
P
S
V
P
D
S
E
Y
D
R
L
F
H
Q
L
K
A
L
E
L
E
H
P
E
F
L
T
S
D
S
P
T
Q
R
V
G
A
K
P
L
-
S
G
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
D
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
G
F
Y
R
D
I
Q
N
---
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
58.48
38%
-57
* C4 *
4GLW
3
DNLJ_STRZP
A:
[2-305]
-------------
N
K
R
M
N
E
-----------------------------
R
E
L
V
E
L
E
T
A
Y
P
E
Q
V
L
A
D
S
P
T
H
R
V
G
G
K
V
-
L
D
G
F
E
K
Y
S
H
Q
Y
P
L
Y
S
L
Q
D
A
F
S
R
E
E
L
D
A
F
D
A
R
V
R
K
E
----
V
A
H
P
T
Y
I
--
C
E
L
K
I
D
G
L
S
I
S
L
T
Y
E
K
G
I
L
V
A
G
V
T
R
G
D
G
S
I
G
E
N
I
T
E
N
L
K
R
V
K
D
I
P
L
T
L
P
E
------
E
L
D
I
T
V
R
G
E
C
Y
M
P
R
A
S
F
D
Q
V
N
Q
A
R
Q
E
N
G
E
P
E
F
A
N
P
R
N
A
A
A
G
T
L
R
Q
L
D
T
A
V
V
A
K
R
N
L
A
T
F
L
Y
Q
E
A
S
P
S
T
------
R
D
S
Q
E
K
G
L
---
K
Y
-
L
E
Q
L
G
F
V
V
N
P
K
R
I
L
A
E
N
I
D
E
I
W
N
F
I
Q
E
V
---
G
Q
---
E
R
E
N
L
P
Y
D
I
D
G
V
V
I
K
V
N
D
L
A
S
Q
E
E
L
G
F
T
V
K
A
P
K
W
A
V
A
Y
K
F
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
57.07
44%
-61
- C4 -
3BAC
4
DNLJ_HAEIN
A:
[7-260]
-------------------------------------------------------------------------------
F
S
Q
I
R
H
E
I
P
M
L
S
L
D
N
A
F
S
D
A
E
F
N
A
F
V
K
R
I
E
D
R
L
ILL
P
K
P
L
T
F
C
--
C
E
P
K
L
D
G
L
A
V
S
I
L
Y
V
N
G
E
L
T
Q
A
A
T
R
G
D
G
T
T
G
E
D
I
T
A
N
I
R
T
I
R
N
V
P
L
Q
L
L
--
T
D
N
P
-
P
A
R
L
E
V
R
G
E
V
F
M
P
H
A
G
F
E
R
L
N
K
Y
A
L
E
H
N
E
K
T
F
A
N
P
R
N
A
A
A
G
S
L
R
Q
L
D
P
N
I
T
S
K
R
P
L
V
L
N
A
Y
G
I
G
I
A
E
G
V
---
G
-
L
P
T
T
H
Y
A
R
---
L
Q
W
L
K
S
I
G
I
P
V
N
P
E
I
R
L
C
N
---
G
A
D
E
V
L
D
F
Y
---
Q
D
I
Q
N
K
R
S
S
L
G
Y
D
I
D
G
T
V
L
K
I
N
D
I
A
L
Q
N
E
L
G
F
I
S
K
A
P
R
W
A
I
A
Y
K
F
P
A
Q
E
E
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------