@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3083: (2016-05-16 )
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVYEFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDDGVLHFAAAAQDHAAA
Atome Classification :
(20 SA)
---.........10........20........30........40........50........60...-----..-----..-----.-----70.........80........90........100.......110.......120.......130.......140.......150.......160.......170.-------.-------......180.......190.......200.......210.......220-.......---.---.230---------..----------.----------..---...----------240---------.--.....-----------------.-----------------------..250--------------.----------.---------..---...-----.-----.--260----------------..-------------------.......270----..--------------------------.......280----..-....-.-290....--...300.......310.....---.---.320-.........330.......340.....----------..350.-.--.....-360-..-..--..-.370---.........380.......390--..----.......400..----.....410.......420.....-..430-----.----.-----.......440......-.450.......-460-------.......470.......480.......490...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MNQ
H
F
D
V
L
I
IGAGLSGIG
T
A
C
H
V
T
AEFP
D
K
T
I
A
L
L
E
R
R
E
RLGGTWDLFRYPGVRSDSD
M
F
T
FGY-----KF-----RP-----W-----
R
-
D
V
K
V
LAD
G
A
S
I
R
Q
Y
I
A
D
T
A
T
EFGVDE
K
I
H
Y
G
L
K
V
NTAEWSSR
Q
C
R
W
T
V
AGVHEATGET
R
T
Y
T
C
D
Y
L
I
S
C
T
G
Y
YNYDAGYLPDFP
G
V
H
RFGGRCVHPQHWP-ED-------L-------DYSG
K
K
V
V
V
IGSG
A
T
A
V
T
L
V
PAMAGSNPGSA
A
H
V
T
M
LQRSP
S
Y
I
F
SL---P
A
V
D
K
I
S
---
E
---
V
L
G
----------
R
F----------L----------
P
D
---
R
W
V
----------
Y
-----------
E
--FGRRR-----------------N-----------------------
I
A
I
----------------
Q
----------
R
---------
K
L
---
Y
Q
A
-----
C
-----
R
--
R
------------------
W
P
-------------------
K
L
M
R
R
L
L
L
------
W
E
--------------------------
V
R
R
R
LGRSVD----MS-NFTP-N-YL
P
W
D
E
R
--LCAVPN
G
D
L
F
K
T
L
A
SG
A
A
S
V
V
---
T
---
D
Q
---
I
E
T
F
T
EKGILCKSGR
E
I
E
A
D
I
I
V
T
ATG----------
L
N
I
Q
M
L-G--
G
M
R
L
I
-VDG-AE-YQ--LP-EK-----MTY
K
G
V
L
LENAP
N
L
A
W
I
I
G
Y----TN----A
S
W
T
L
K
S
DI
A
G
A
----
Y
L
C
R
L
L
R
H
MADN
G
Y
T
VATPRD
A
Q
-
D
C
A
-------
L
----
D
-----VG
M
F
D
QLNS
G
Y
V
KRGQ-DIMPRQGSKH
P
-
W
R
V
-------
L
M
H
YEKD
A
K
I
L
L
EDPIDD
G
V
L
H
F
A
A
AAQDHAAA
3
PsiBlast_PDB
93.29
23%
-107
- C5 -
3UOY
3
OTEMO_PSEPU
A:
[10-479]
-------
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
--
G
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
F
A
L
K
G
I
I
-----
P
E
-----
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
--
P
L
S
A
S
R
M
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
D
AEGAPKG
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
----
E
T
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
G
N
S
P
M
S
K
E
K
M
---
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
-----
I
----------
L
-----------
E
--
Y
V
K
S
T
-----------------
D
-----------------------
T
A
F
PYHRDPRKGTDVS
E
S
E
R
----------
D
---------
A
F
---
F
E
E
-----
L
-----
Y
--
R
------------------
Q
P
GYGIWLSGFRDLLLN
K
E
S
N
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
D
P
V
V
----
A
E
-
K
L
I
P
-
K
-
D
H
P
F
G
A
K
--
R
V
P
M
E
T
-
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
---
I
R
EAP
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
FDG
S
L
D
R
---
I
D
I
R
G
K
-
D
--
N
V
R
L
I
-
D
A
W
-
A
E
--------
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
----
G
S
T
F
C
N
V
G
V
C
G
G
L
Q
A
E
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
-
E
--------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.06
23%
-106
- C5 -
3UP5
2
OTEMO_PSEPU
A:
[10-479]
-------
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
--
G
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
F
A
L
K
G
I
I
-----
P
E
-----
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
--
P
L
S
A
S
R
M
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
D
AEGAPKG
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
----
E
T
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
G
N
S
P
M
S
K
E
K
M
---
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
-----
I
----------
L
-----------
E
--
Y
V
K
S
T
-----------------
D
-----------------------
T
A
F
PYHRDPRKGTDVS
E
S
E
R
----------
D
---------
A
F
---
F
E
E
-----
L
-----
Y
--
R
------------------
Q
P
GYGIWLSGFRDLLLN
K
E
S
N
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
D
P
V
V
----
A
E
-
K
L
I
P
-
K
-
D
H
P
F
G
A
K
--
R
V
P
M
E
T
-
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
---
I
R
EAP
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
FDG
S
L
D
R
---
I
D
I
R
G
K
-
D
--
N
V
R
L
I
-
D
A
W
-
A
E
--------
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
----
G
S
T
F
C
N
V
G
V
C
G
G
L
Q
A
E
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
-
E
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.63
23%
-106
- C5 -
3UP4
2
OTEMO_PSEPU
A:
[10-488]
-------
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
--
G
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
F
A
L
K
G
I
I
-----
P
E
-----
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
--
P
L
S
A
S
R
M
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
-GAPKG--
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
----
E
T
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
G
N
S
P
M
S
K
E
K
M
---
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
-----
I
----------
L
-----------
E
--
Y
V
K
S
T
-----------------
D
-----------------------
T
A
F
P
Y
H
R
D
PRKGTDVS
E
S
E
R
----------
D
---------
A
F
---
F
E
E
-----
L
-----
Y
--
R
------------------
Q
P
GYGIWLSGFRDLLLN
K
E
S
N
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
D
P
V
V
----
A
E
-
K
L
I
P
-
K
-
D
H
P
F
G
A
K
--
R
V
P
M
E
T
-
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
---
I
R
EAP
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
FDAVT
G
S
L
D
R
I
D
I
R
G
K
-
D
--
N
V
R
L
I
-
D
A
W
-
A
E
--------
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
----
G
S
T
F
C
N
V
G
V
C
G
G
L
Q
A
E
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
-
E
--------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.50
23%
-108
- C5 -
3UOX
1
OTEMO_PSEPU
A:
[10-479]
-------
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
--
G
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
F
A
L
K
G
I
I
-----
P
E
-----
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
--
P
L
S
A
---
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
D
AEGAPKG
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
----
E
T
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
G
N
S
P
M
S
K
E
K
M
---
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
-----
I
----------
L
-----------
E
--
Y
V
K
S
T
-----------------
D
-----------------------
T
A
F
PYHRDPRKGTDVS
E
S
E
R
----------
D
---------
A
F
---
F
E
E
-----
L
-----
Y
--
R
------------------
Q
P
GYGIWLSGFRDLLLN
K
E
S
N
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
D
P
V
V
----
A
E
-
K
L
I
P
-
K
-
D
H
P
F
G
A
K
--
R
V
P
M
E
T
-
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
---
I
R
EAP
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
FDAVTGSLDR
I
D
I
R
G
K
-
D
--
N
V
R
L
I
-
D
A
W
-
A
E
--------
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
----
G
S
T
F
C
N
V
G
V
C
G
G
L
Q
A
E
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
-
E
--------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.24
23%
-108
- C5 -
3UOZ
2
OTEMO_PSEPU
A:
[10-479]
-------
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
--
G
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
F
A
L
K
G
I
I
-----
P
E
-----
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
--
P
L
S
A
S
R
M
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
D
AEGAPKG
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
----
E
T
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
G
N
S
P
M
S
K
E
K
M
---
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
-----
I
----------
L
-----------
E
--
Y
V
K
S
T
-----------------
D
-----------------------
T
A
F
PYHRDPRKGTDVS
E
S
E
R
----------
D
---------
A
F
---
F
E
E
-----
L
-----
Y
--
R
------------------
Q
P
GYGIWLSGFRDLLLN
K
E
S
N
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
D
P
V
V
----
A
E
-
K
L
I
P
-
K
-
D
H
P
F
G
A
K
--
R
V
P
M
E
T
-
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
---
I
R
EAP
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
FDAVT
G
S
L
D
R
I
D
I
R
G
K
-
D
--
N
V
R
L
I
-
D
A
W
-
A
E
--------
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
----
G
S
T
F
C
N
V
G
V
C
G
G
L
Q
A
E
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
-
E
--------------------------------------------------------------------------------------------
112
HHSearch
90.63
24%
-96
- C4 -
3UOX
1
OTEMO_PSEPU
A:
[7-541]
----
S
P
A
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
G
--
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
-----
F
A
-----
L
K
GIIPE
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
P
L
--
S
A
---
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
D
-------
A
EGAPKGV
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
E
T
----
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
---
G
N
S
P
M
S
K
E
K
M
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
---
I
L
E
----------
Y
V
K
S
TDTAFPYH
R
--
D
P
R
K
G
TDVS
E
S
E
R
---------
D
-----------------------
A
F
F
----------------
E
----------
E
L
Y
R
QPGYGI
W
L
---
S
G
F
-----
R
DLLLN
K
--
E
------------------
S
N
-------------------
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
-
D
P
V
----
V
A
E
K
L
I
P
K
D
-
H
P
F
G
A
K
R
--
V
P
--
M
E
T
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
IRE
A
P
---
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
----------
F
D
A
V
T
G
-
S
LD
R
I
D
I
R
G
K
D
N
-
V
R
-
L
I
D
A
W
A
E
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
GSTF
C
N
V
G
V
C
G
G
L
Q
A
E
----
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
E
N
R
W
T
E
E
V
Y
A
D
F
----
S
R
----
T
L
L
A
-
E
A
N
A
W
W
V
K
T
T
T
K
P
D
G
S
V
V
R
R
T
L
V
H
V
S
G
-------
G
P
E
Y
R
K
R
C
E
Q
V
A
Y
N
N
Y
N
G
---------------
101
Fugue
90.55
22%
-100
- C4 -
1W4X
2
PAMO_THEFY
A:
[10-542]
RRQ
P
P
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
Y
A
L
Y
R
L
R
E
--
L
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
-----
N
H
G
D
R
I
R
A
R
Y
L
I
M
A
S
G
Q
L
S
V
P
--
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
K
Q
----
A
A
E
L
F
V
F
Q
R
T
P
H
F
A
V
P
A
---
R
N
A
P
L
D
P
---
E
---
F
L
A
----------
D
L
----------
K
----------
K
R
---
Y
A
E
----------
F
-----------
R
--
E
E
S
R
N
TPGGTHRYQGPKSALEV
S
-----------------------
D
E
E
----------------
L
----------
V
---------
E
T
---
L
E
R
-----
Y
-----
W
--
Q
E
GGPDILAAYRDILRD
R
D
A
N
-------------------
E
R
V
A
E
F
I
R
------
N
K
--------------------------
I
R
N
T
V
R
D
P
E
V
----
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
--
R
L
I
L
E
I
D
-
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
TL
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
-
V
G
N
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
P
GSPS
A
L
----
S
N
M
L
V
S
I
E
Q
H
V
E
----
W
V
T
D
H
I
A
Y
M
F
K
N
G
L
T
R
S
E
A
V
L
E
K
-
E
D
E
-------
W
----
V
-----
E
H
V
N
E
I
A
D
E
T
L
Y
P
M
T
A
-
S
W
Y
T
G
A
N
V
P
G
K
-
P
R
V
F
MLYVGG
F
H
R
Y
R
Q
I
C
D
E
V
A
A
K
G
Y
E
G
F
V
L
T
-----------
1
PsiBlast_PDB
90.11
23%
-104
- C5 -
3UOV
1
OTEMO_PSEPU
A:
[10-479]
-------
L
D
A
V
V
I
G
A
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
--
G
M
K
V
L
G
I
E
A
G
E
D
V
G
G
T
W
Y
W
N
R
Y
P
G
C
R
L
D
T
E
S
Y
A
Y
G
Y
F
A
L
K
G
I
I
-----
P
E
-----
W
-----
E
-
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
V
R
K
H
Y
R
F
N
T
R
V
T
A
A
R
Y
V
E
N
D
R
L
W
E
V
T
L
D
N
E
-----
E
V
V
T
C
R
F
L
I
S
A
T
G
--
P
L
S
A
S
--
P
D
I
K
G
I
D
S
F
K
G
E
S
F
H
S
S
R
W
P
-
T
D
AEGAPKG
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
A
T
G
V
Q
I
I
P
I
A
A
----
E
T
A
K
E
L
Y
V
F
Q
R
T
P
N
W
C
T
P
L
G
N
S
P
M
S
K
E
K
M
---
D
---
S
L
R
----------
N
R
----------
Y
----------
P
T
-----
I
----------
L
-----------
E
--
Y
V
K
S
T
-----------------
D
-----------------------
T
A
F
PYHRDPRKGTDVS
E
S
E
R
----------
D
---------
A
F
---
F
E
E
-----
L
-----
Y
--
R
------------------
Q
P
GYGIWLSGFRDLLLN
K
E
S
N
K
F
L
A
D
F
V
A
------
K
K
--------------------------
I
R
Q
R
V
K
D
P
V
V
----
A
E
-
K
L
I
P
-
K
-
D
H
P
F
G
A
K
--
R
V
P
M
E
T
-
N
Y
Y
E
T
Y
N
R
D
N
V
H
L
V
---
D
---
I
R
EAP
I
Q
E
V
T
P
E
G
I
K
T
A
D
A
-
A
Y
D
L
D
V
I
I
Y
A
T
G
FDTGSLDR--
I
D
I
R
G
K
-
D
--
N
V
R
L
I
-
D
A
W
-
A
E
--------
G
P
-----
S
T
Y
L
G
L
Q
A
R
G
F
P
N
F
F
T
L
V
G
P
----
H
N
----
G
S
T
F
C
N
V
G
V
C
G
G
L
Q
A
E
W
V
L
R
M
I
S
Y
M
K
D
N
G
F
T
Y
S
E
P
T
Q
A
A
-
E
--------------------------------------------------------------------------------------------
113
HHSearch
87.83
22%
-99
- C4 -
4AP3
4
?
A:
[20-541]
-----
T
S
Y
D
V
V
V
V
G
A
G
I
A
G
L
Y
A
I
H
R
F
R
S
Q
G
--
L
T
V
R
A
F
E
A
A
S
G
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
V
E
S
I
D
Y
S
Y
-----
S
F
-----
S
P
-----
E
L
E
Q
E
W
N
-
W
S
E
K
Y
A
T
Q
P
E
I
L
A
Y
L
E
H
V
A
D
R
F
D
L
R
R
D
I
R
F
D
T
R
V
T
S
A
V
L
D
E
E
G
L
R
W
T
V
R
T
D
R
G
-----
D
E
V
S
A
R
F
L
V
V
A
A
G
P
L
--
S
N
A
N
T
P
A
F
D
G
L
D
R
F
T
G
D
I
V
H
T
A
R
W
P
-
H
D
G------
V
-------
D
F
T
G
K
R
V
G
V
I
G
T
G
S
S
G
I
Q
S
I
P
I
I
A
E
Q
----
A
E
Q
L
F
V
F
Q
R
S
A
N
Y
S
I
P
A
---
G
----
D
D
---
A
---
T
R
A
E
Q
K
A
N
Y
A
E
R
R
R
L
S
R
--------
E
SGGGSPHRPH
P
K
---
S
A
L
----------
E
-----------
V
S
E
E
E
R
R
A
-----------------------------------------
V
Y
E
----------------
E
----------
R
---------
W
K
L
G
G
V
L
F
-----
S
-----
K
--
A
------------------
F
P
DQLTD
P
A
A
N
----------
D
T
A
R
A
F
W
E
------
E
K
--------------------------
I
R
A
V
V
D
-
D
P
A
----
V
A
E
L
L
T
P
K
D
-
H
A
I
G
A
K
R
--
I
V
--
L
D
S
G
Y
Y
E
T
Y
N
R
D
N
V
E
L
V
---
D
LRS
T
P
---
I
V
G
M
D
E
T
G
I
V
T
-
T
G
A
H
Y
D
L
D
M
I
V
L
A
T
G
----------
F
D
A
M
T
G
S
L
D
-
K
L
E
I
V
G
R
G
G
-
R
T
-
L
K
E
T
W
A
A
G
P
-----
R
T
Y
L
G
L
G
I
D
G
F
P
N
F
F
N
L
T
G
P
----
G
S
PSVL
A
N
M
V
L
H
S
E
L
H
V
D
----
W
V
A
D
A
I
A
Y
L
D
A
R
G
A
A
G
I
E
G
T
P
E
A
V
A
D
W
V
E
E
----
C
----
R
N
R
A
E
A
S
L
L
N
-
S
A
N
S
W
Y
L
G
A
N
-----
R
V
F
---
M
P
-
F
L
G
G------
F
G
V
Y
R
E
I
I
T
E
V
A
E
S
G
Y
-----------------
110
HHSearch
87.02
23%
-96
- C4 -
1W4X
2
PAMO_THEFY
A:
[14-537]
----
P
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
Y
A
L
Y
R
L
R
E
L
G
--
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
-----
S
E
E
V
L
Q
E
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
-----
D
R
I
R
A
R
Y
L
I
M
A
S
G
Q
L
--
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
-
H
E
P------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
K
Q
----
A
A
E
L
F
V
F
Q
R
T
P
H
F
A
V
P
A
---
R
N
A
P
L
D
P
---
E
F
L
A
D
L
K
----------
K
R
Y
A
E
F
R
E
E
S
R
N
T
----------
P
G
---
G
T
H
RYQGPKSALE
V
S
D
E
E
-------
L
--
V
E
T
L
E
-----------------
R
-----------------------
Y
W
Q
----------------
E
----------
G
GPD------
I
L
---
A
A
Y
RDI--
L
-----
R
D
R
D
------------------
A
N
-------------------
E
R
V
A
E
F
I
R
------
N
K
--------------------------
I
R
N
T
V
R
-
D
P
E
----
V
A
E
R
L
V
P
-
K
G
Y
P
F
G
T
K
R
--
L
I
--
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
---
D
TLS
A
P
---
I
E
T
I
T
P
R
G
V
R
T
S
E
-
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
L
F
K
I
D
I
R
G
V
G
N
-
V
A
-
L
K
E
K
W
A
A
G
P
-----
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
P
----
G
S
PSAL
S
N
M
L
V
S
I
E
Q
H
V
E
----
W
V
T
D
H
I
A
Y
M
F
K
N
G
L
T
R
S
E
A
V
L
E
K
E
D
E
W
V
E
H
----
V
----
N
E
I
A
D
E
T
L
Y
P
-
M
T
A
S
W
Y
T
G
A
N
V
P
G
K
P
R
V
F
---
M
L
-
Y
V
G
G------
F
H
R
Y
R
Q
I
C
D
E
V
A
A
K
G
Y
E
----------------
111
HHSearch
85.85
20%
-89
- C4 -
4RG3
4
?
A:
[14-537]
----
T
H
T
V
D
A
V
V
I
G
A
G
F
G
G
I
Y
A
V
H
K
L
H
H
E
L
-
G
L
T
T
V
G
F
D
K
A
D
G
P
G
G
T
W
Y
W
N
R
Y
P
G
A
L
S
D
T
E
S
H
L
Y
R
F
-----
S
F
-----
D
R
D
L
L
Q
-
E
-----
S
T
W
K
T
T
Y
I
T
Q
P
E
I
L
E
Y
L
E
D
V
V
D
R
F
D
L
R
R
H
F
K
F
G
T
E
V
T
S
A
L
Y
L
D
D
E
N
L
W
E
V
T
T
D
H
G
-----
E
V
Y
R
A
K
Y
V
V
N
A
V
G
L
L
--
S
A
I
N
F
P
N
L
P
G
L
D
T
F
E
G
E
T
I
H
T
A
A
W
P
-
E
G
-------
K
-------
S
L
A
G
R
R
V
G
V
I
G
T
G
S
T
G
Q
Q
V
I
T
S
L
A
P
E
----
V
E
H
L
T
V
F
V
R
T
P
Q
Y
S
V
P
V
---
G
N
R
P
V
N
P
---
E
---
Q
I
A
----------
E
-----------
I
----------
K
A
---
D
Y
D
----------
R
-----------
I
--
W
E
R
A
K
-----------------
N
SAVAFGFEESTLPAMSVS
E
E
E
R
N
R
I
F
----------------
Q
E
A
W
D
H
GG
G
F
R
F
---------
M
F
---
G
T
F
GDIAT
D
-----
E
--
A
------------------
A
N
-------------------
E
A
A
A
S
F
I
R
------
A
K
--------------------------
V
A
E
I
I
E
-
D
P
E
----
T
A
R
K
L
M
P
-
K
-
G
-
L
F
A
K
R
--
P
L
--
C
D
S
G
Y
Y
E
V
Y
N
R
P
N
V
E
A
V
---
A
IKE
N
P
---
I
R
E
V
T
A
K
G
V
V
T
E
D
G
V
L
H
E
L
D
V
L
V
F
A
T
G
----------
F
D
A
V
D
G
N
Y
R
-
R
I
E
I
R
G
R
D
G
-
L
H
-
I
N
D
H
W
D
G
Q
P
-----
T
S
Y
L
G
V
S
T
A
N
F
P
N
W
F
M
V
L
G
P
----
N
G
PF--
T
N
L
P
P
S
I
E
T
Q
V
E
----
W
I
S
D
T
I
G
Y
A
E
R
N
G
V
R
A
I
E
P
T
P
E
A
E
A
E
W
T
E
T
----
C
T
E
I
A
N
A
----
T
L
F
T
-
K
G
D
S
W
I
F
G
A
N
I
P
G
K
K
P
S
V
---
L
F
-
Y
L
G
G------
L
R
N
Y
R
A
V
M
A
E
V
A
A
D
G
Y
R
G
---------------
16
PsiBlast_PDB
85.81
25%
-97
- C5 -
2YLS
2
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
R
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
AGP
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.75
25%
-97
- C5 -
2YLR
2
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
R
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
AGP
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.61
25%
-95
- C5 -
4D04
3
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
D
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
R
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.35
25%
-98
- C5 -
4C74
3
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
R
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.33
25%
-95
- C5 -
2YM2
2
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
-
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
K
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.00
25%
-96
- C5 -
4OVI
6
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
R
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.79
25%
-97
- C5 -
4C77
3
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
K
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
AGP
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.77
25%
-96
- C5 -
4D03
4
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
D
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
R
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.76
25%
-93
- C5 -
2YLW
3
PAMO_THEFY
A:
[15-436]
-----
E
E
V
D
V
L
V
V
G
A
G
F
S
G
L
-
Y
A
L
Y
R
L
R
E
L
-
G
R
S
V
H
V
I
E
T
A
G
D
V
G
G
V
W
Y
W
N
R
Y
P
G
A
R
C
D
I
E
S
I
E
Y
C
Y
-----
S
F
S
E
E
V
L
Q
E
-----
W
-----
N
-
W
T
E
R
Y
A
S
Q
P
E
I
L
R
Y
I
N
F
V
A
D
K
F
D
L
R
S
G
I
T
F
H
T
T
V
T
A
A
A
F
D
E
A
T
N
T
W
T
V
D
T
N
H
G
D
R
I
R
A
R
-----
Y
L
I
M
A
S
G
--
Q
L
S
V
P
Q
L
P
N
F
P
G
L
K
D
F
A
G
N
L
Y
H
T
G
N
W
P
H
E
P
-------
V
-------
D
F
S
G
Q
R
V
G
V
I
G
T
G
S
S
G
I
Q
V
S
P
Q
I
A
----
K
Q
A
A
E
L
F
V
F
Q
R
T
P
H
--
F
A
V
---
P
A
--
R
N
A
---
P
---
L
D
P
----------
E
F
----------
L
----------
A
D
L
K
K
R
Y
A
----------
E
-----------
F
--
R
E
E
S
R
-----------------
N
-----------------------
T
P
G
----------------
G
----------
T
---------
H
R
---
Y
Q
G
-----
P
-----
K
--
S
------------------
A
L
-------------------
E
V
S
D
E
E
L
V
E
T
L
E
R
Y
W
Q
E
GGPDILAAYRDILRD
R
D
A
N
E
R
V
A
E
F
I
R
N
K
I
R
N
T
V
R
D
P
E
V
A
E
-
R
L
V
P
-
K
-
G
Y
P
F
G
T
K
K
L
I
L
E
I
D
Y
Y
E
M
F
N
R
D
N
V
H
L
V
D
T
L
---
S
---
A
P
---
I
E
T
I
T
P
R
G
V
R
T
-
S
E
R
E
Y
E
L
D
S
L
V
L
A
T
G
----------
F
D
A
L
T
G
-
A
--
L
F
K
I
D
-
I
R
G
V
G
N
-
V
A
--
L
K
-
E
K
W
A
A
G
P
R
T
Y
L
G
L
S
T
A
G
F
P
N
L
F
F
I
A
G
------------------------------------------------------------------------------------------------------------------------------------------------